----------------------------------------------------------------------
Changes included in 2024-07-22.1
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Overview:
- 177 new proteins added, 148 of them new alleles
- Push to curate literature, 607 PubMed references added
- Review, addition, and standardization of the ipaH genes and nomenclature
- Updates to phenotype information from literature, especially for blaSHV,
  blaOXA, and blaKPCs
- Point mutations for two new species, Burkholderia_mallei and
  Corynebacterium_diphtheriae
- Added virulence factors for Corynebacterium_diphtheriae
- New point mutations for Clostridioides_difficile, Enterococcus_faecium,
  Escherichia, Klebsiella_pneumoniae, Neisseria_gonorrhoeae, and Salmonella
- crpP changed from 'core' to 'plus' because of an apparent lack of association
  with phenotype

Summary:
   Total proteins: 8355
        Core proteins: 7088
        Plus proteins: 1264
   AMR proteins: 7138
   STRESS proteins: 257
   VIRULENCE proteins: 960
   PubMed references: 5049
   Point mutations: 1351
   Point mutation reference sequences: 242
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Corynebacterium_diphtheriae,
       Enterobacter_asburiae, Enterobacter_cloacae, Enterococcus_faecalis,
       Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae,
       Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa,
       Salmonella, Serratia_marcescens, Staphylococcus_aureus, Staphylococcus_pseudintermedius,
       Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes,
       Vibrio_cholerae, Vibrio_parahaemolyticus, Vibrio_vulnificus
   HMMs: 747

Updates since release 2024-05-02.2:
   Proteins added: 177
       Core proteins added: 148
       Plus proteins added: 29
   AMR proteins added: 150
   VIRULENCE proteins added: 27
   Alleles added: 140
   PubMed references added: 607
   PubMed references removed: 5
   Point mutations added: 42
   Added organism options: Burkholderia_mallei, Corynebacterium_diphtheriae
   Proteins removed: 2
       Core proteins removed: 1
       Plus proteins removed: 1
   Reference Gene Catalog entries changed: 540
   Hierarchy nodes added: 37
   Hierarchy nodes removed: 5
   Hierarchy nodes changed: 5

Added proteins
    core AMR AMR
        dfrA51           NG_242639.1 WP_000781812.1     trimethoprim-resistant dihydrofolate reductase DfrA51
        ant(9)-Ic        NG_242635.1 WP_021586183.1     aminoglycoside nucleotidyltransferase ANT(9)-Ic
        dfrA49           NG_242636.1 WP_038694170.1     trimethoprim-resistant dihydrofolate reductase DfrA49
        dfrA50           NG_242637.1 WP_040203768.1     trimethoprim-resistant dihydrofolate reductase DfrA50
        pbp2m            NG_242640.1 WP_049151672.1     penicillin-binding protein PBP2M
        aadA36           NG_242634.1 WP_071821194.1     ANT(3'')-I family aminoglycoside nucleotidyltransferase AadA36
        dfrA50           NG_242638.1 WP_130949671.1     trimethoprim-resistant dihydrofolate reductase DfrA50
        aadA33           NG_242633.1 WP_251464169.1     ANT(3'')-I family aminoglycoside nucleotidyltransferase AadA33
        blaACT-131       NG_242641.1 WP_059306485.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-131
        blaACT-140       NG_242642.1 WP_367187910.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-140
        blaACT-141       NG_242643.1 WP_032628014.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-141
        blaACT-142       NG_242644.1 WP_032637705.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-142
        blaACT-143       NG_242645.1 WP_045282250.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-143
        blaACT-144       NG_242646.1 WP_047054053.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-144
        blaACT-145       NG_242647.1 WP_048980831.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-145
        blaACT-146       NG_242648.1 WP_049138506.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-146
        blaACT-147       NG_242649.1 WP_062932487.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-147
        blaACT-148       NG_242650.1 WP_063138560.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-148
        blaACT-149       NG_242651.1 WP_095450405.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-149
        blaACT-150       NG_242652.1 WP_117581582.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-150
        blaACT-151       NG_242653.1 WP_126524654.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-151
        blaACT-152       NG_242654.1 WP_155026593.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-152
        blaACT-153       NG_242655.1 WP_193542281.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-153
        blaACT-154       NG_242656.1 WP_200557972.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-154
        blaACT-155       NG_242657.1 WP_215771935.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-155
        blaACT-156       NG_242658.1 WP_220120526.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-156
        blaACT-157       NG_242659.1 WP_222663284.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-157
        blaACT-158       NG_242660.1 WP_228333159.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-158
        blaACT-159       NG_242661.1 WP_233003445.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-159
        blaACT-160       NG_242662.1 WP_248215418.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-160
        blaACT-161       NG_242663.1 WP_252462726.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-161
        blaACT-162       NG_242664.1 WP_259363839.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-162
        blaACT-163       NG_242665.1 WP_320700915.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-163
        blaACT-164       NG_242666.1 WP_320724323.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-164
        blaACT-165       NG_242667.1 WP_333043301.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-165
        blaACT-166       NG_242668.1 WP_333169117.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-166
        blaACT-167       NG_242669.1 WP_367187911.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-167
        blaACT-168       NG_242670.1 WP_367187912.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-168
        blaACT-169       NG_242671.1 WP_367187913.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-169
        blaACT-170       NG_242672.1 WP_367187914.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-170
        blaACT-171       NG_242673.1 WP_367187915.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-171
        blaACT-172       NG_242674.1 WP_367187916.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-172
        blaACT-173       NG_242675.1 WP_367187917.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-173
        blaACT-174       NG_242676.1 WP_367187918.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-174
        blaACT-175       NG_242677.1 WP_367187919.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-175
        blaACT-176       NG_242678.1 WP_367187920.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-176
        blaACT-177       NG_242679.1 WP_367187921.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-177
        blaACT-178       NG_242680.1 WP_367187922.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-178
        blaACT-179       NG_242681.1 WP_367187923.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-179
        blaACT-180       NG_242682.1 WP_367187924.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-180
        blaACT-181       NG_242683.1 WP_367187925.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-181
        blaACT-182       NG_242684.1 WP_367187926.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-182
        blaACT-183       NG_242685.1 WP_367187927.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-183
        blaACT-184       NG_242686.1 WP_367187928.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-184
        blaACT-185       NG_242687.1 WP_367187929.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-185
        blaACT-186       NG_242688.1 WP_367187930.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-186
        blaACT-187       NG_242689.1 WP_367187931.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-187
        blaACT-188       NG_242690.1 WP_367187932.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-188
        blaACT-189       NG_242691.1 WP_367187933.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-189
        blaACT-190       NG_242692.1 WP_367187934.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-190
        blaACT-191       NG_242693.1 WP_367187935.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-191
        blaACT-192       NG_242694.1 WP_367187936.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-192
        blaACT-193       NG_242695.1 WP_367187937.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-193
        blaACT-194       NG_242696.1 WP_367187938.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-194
        blaAFM-5         NG_242697.1 WP_367187939.1     subclass B1 metallo-beta-lactamase AFM-5
        blaBMHC-1        NG_242698.1 WP_119059468.1     subclass B1 metallo-beta-lactamase BMHC-1
        blaCMH-14        NG_242699.1 WP_038984046.1     class C beta-lactamase CMH-14
        blaCMH-15        NG_242700.1 WP_040020536.1     class C beta-lactamase CMH-15
        blaCMH-16        NG_242701.1 WP_045902232.1     class C beta-lactamase CMH-16
        blaCMH-17        NG_242702.1 WP_050859785.1     class C beta-lactamase CMH-17
        blaCMH-18        NG_242703.1 WP_058660625.1     class C beta-lactamase CMH-18
        blaCMH-19        NG_242704.1 WP_058678916.1     class C beta-lactamase CMH-19
        blaCMH-20        NG_242705.1 WP_058680758.1     class C beta-lactamase CMH-20
        blaCMH-22        NG_242707.1 WP_095907254.1     class C beta-lactamase CMH-22
        blaCMH-23        NG_242708.1 WP_118283990.1     class C beta-lactamase CMH-23
        blaCMH-24        NG_242709.1 WP_139937027.1     class C beta-lactamase CMH-24
        blaCMH-25        NG_242710.1 WP_308926360.1     class C beta-lactamase CMH-25
        blaCMH-26        NG_242711.1 WP_367187940.1     class C beta-lactamase CMH-26
        blaCMH-27        NG_242712.1 WP_353798104.1     class C beta-lactamase CMH-27
        blaCMH-28        NG_242713.1 WP_367187941.1     class C beta-lactamase CMH-28
        blaCMH-29        NG_242714.1 WP_367187942.1     class C beta-lactamase CMH-29
        blaCMH-30        NG_242715.1 WP_367187943.1     class C beta-lactamase CMH-30
        blaCMH-31        NG_242716.1 WP_367187944.1     class C beta-lactamase CMH-31
        blaCMH-32        NG_242717.1 WP_367187945.1     class C beta-lactamase CMH-32
        blaCMH-33        NG_242718.1 WP_367187946.1     class C beta-lactamase CMH-33
        blaCMH-34        NG_242719.1 WP_367187947.1     class C beta-lactamase CMH-34
        blaCMY-191       NG_242720.1 WP_187795500.1     class C beta-lactamase CMY-191
        blaGES-60        NG_242721.1 WP_367187948.1     extended-spectrum class A beta-lactamase GES-60
        blaGES-61        NG_242722.1 WP_323579967.1     class A beta-lactamase GES-61
        blaKPC-217       NG_242723.1 WP_367187949.1     inhibitor-resistant class A beta-lactamase KPC-217
        blaKPC-218       NG_242724.1 WP_367187950.1     inhibitor-resistant class A beta-lactamase KPC-218
        blaKPC-223       NG_242725.1 WP_367187951.1     carbapenem-hydrolyzing class A beta-lactamase KPC-223
        blaKPC-224       NG_242726.1 WP_367187952.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-224
        blaKPC-225       NG_242727.1 WP_367187953.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-225
        blaKPC-226       NG_242728.1 WP_367187954.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-226
        blaKPC-227       NG_242729.1 WP_367187955.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-227
        blaKPC-228       NG_242730.1 WP_348866574.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-228
        blaKPC-230       NG_242731.1 WP_367187956.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-230
        blaMIR-27        NG_242732.1 WP_367187957.1     cephalosporin-hydrolyzing class C beta-lactamase MIR-27
        blaMIR-28        NG_242733.1 WP_008502936.1     cephalosporin-hydrolyzing class C beta-lactamase MIR-28
        blaMIR-29        NG_242734.1 WP_100122263.1     cephalosporin-hydrolyzing class C beta-lactamase MIR-29
        blaMIR-30        NG_242735.1 WP_177317028.1     cephalosporin-hydrolyzing class C beta-lactamase MIR-30
        blaMIR-31        NG_242736.1 WP_367187958.1     cephalosporin-hydrolyzing class C beta-lactamase MIR-31
        blaMIR-32        NG_242737.1 WP_367187959.1     cephalosporin-hydrolyzing class C beta-lactamase MIR-32
        blaMIR-33        NG_242738.1 WP_367187960.1     cephalosporin-hydrolyzing class C beta-lactamase MIR-33
        blaMIR-34        NG_242739.1 WP_367187961.1     cephalosporin-hydrolyzing class C beta-lactamase MIR-34
        blaMIR-35        NG_242740.1 WP_367187962.1     cephalosporin-hydrolyzing class C beta-lactamase MIR-35
        blaNDM-69        NG_242741.1 WP_367187963.1     subclass B1 metallo-beta-lactamase NDM-69
        blaNDM-70        NG_242742.1 WP_367187964.1     subclass B1 metallo-beta-lactamase NDM-70
        blaOXA-1204      NG_242743.1 WP_309258826.1     OXA-10 family class D beta-lactamase OXA-1204
        blaOXA-1241      NG_242744.1 WP_367187965.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1241
        blaOXA-1242      NG_242745.1 WP_367187966.1     OXA-48 family class D beta-lactamase OXA-1242
        blaOXA-1243      NG_242746.1 WP_367187967.1     OXA-2 family class D beta-lactamase OXA-1243
        blaOXA-1244      NG_242747.1 WP_367187968.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1244
        blaOXA-1245      NG_242748.1 WP_034002900.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1245
        blaOXA-1246      NG_242749.1 WP_171889086.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1246
        blaOXA-1247      NG_242750.1 WP_311055936.1     OXA-10 family class D beta-lactamase OXA-1247
        blaOXA-1248      NG_242751.1 WP_367187969.1     OXA-10 family class D beta-lactamase OXA-1248
        blaOXA-1249      NG_242752.1 WP_367187970.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1249
        blaOXA-1250      NG_242753.1 WP_150035346.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1250
        blaOXA-1251      NG_242754.1 WP_367187971.1     OXA-258 family class D beta-lactamase OXA-1251
        blaOXA-1252      NG_242755.1 WP_124213927.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1252
        blaOXA-1253      NG_242756.1 WP_034072939.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1253
        blaOXA-1254      NG_242757.1 WP_094776403.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1254
        blaOXA-1255      NG_242758.1 WP_104052979.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1255
        blaOXA-1256      NG_242759.1 WP_367187972.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1256
        blaOXA-1257      NG_242760.1 WP_367187973.1     OXA-10 family class D beta-lactamase OXA-1257
        blaPDC-593       NG_242613.1 WP_340638818.1     class C beta-lactamase PDC-593
        blaPDC-594       NG_242614.1 WP_340638819.1     class C beta-lactamase PDC-594
        blaPDC-595       NG_242615.1 WP_340638820.1     class C beta-lactamase PDC-595
        blaPDC-596       NG_242616.1 WP_340638821.1     class C beta-lactamase PDC-596
        blaPDC-597       NG_242617.1 WP_210983323.1     class C beta-lactamase PDC-597
        blaPDC-598       NG_242618.1 WP_340638822.1     class C beta-lactamase PDC-598
        blaPDC-599       NG_242619.1 WP_340638823.1     class C beta-lactamase PDC-599
        blaPDC-600       NG_242620.1 WP_340638824.1     class C beta-lactamase PDC-600
        blaPDC-601       NG_242761.1 WP_367187974.1     class C beta-lactamase PDC-601
        blaPNC-2         NG_242762.1 WP_367187975.1     extended-spectrum class C beta-lactamase PNC-2
        blaPNC-3         NG_242763.1 WP_367187976.1     extended-spectrum class C beta-lactamase PNC-3
        blaSHV-19        NG_242764.1 WP_367187977.1     class A beta-lactamase SHV-19
        blaSHV-245       NG_242765.1 WP_367187978.1     class A beta-lactamase SHV-245
        blaSHV-6         NG_242766.1 WP_367187979.1     extended-spectrum class A beta-lactamase SHV-6
        blaSHV-84        NG_242767.1 WP_367187980.1     inhibitor-resistant broad-spectrum class A beta-lactamase SHV-84
        blaTEM-252       NG_242768.1 WP_355410643.1     class A beta-lactamase TEM-252
        mcr-4.9          NG_242769.1 WP_281052475.1     phosphoethanolamine--lipid A transferase MCR-4.9
        qnrB99           NG_242770.1 WP_367187981.1     quinolone resistance pentapeptide repeat protein QnrB99
        qnrE5            NG_242771.1 WP_367187982.1     quinolone resistance pentapeptide repeat protein QnrE5
        qnrE6            NG_242772.1 WP_367187983.1     quinolone resistance pentapeptide repeat protein QnrE6
        qnrE7            NG_242773.1 WP_045399951.1     quinolone resistance pentapeptide repeat protein QnrE7
    plus AMR AMR
        crpP             HM560971.1 AEQ93536.1          ICE-associated protein CrpP
        vanS-Cd          NZ_CP011847.1 WP_011861275.1   VanG-Cd-type vancomycin resistance histidine kinase VanS
    plus VIRULENCE VIRULENCE
        tox              K01722.1 AAA32182.1            diphtheria toxin Tox
        ipaH7.8          AF386526.1 AAL72346.1          T3SS effector E3 ubiquitin-protein ligase IpaH7.8
        ipaH4.5          AF386526.1 AAL72347.1          T3SS effector E3 ubiquitin-protein ligase IpaH4.5
        ipaH2.5          AF386526.1 AAL72348.1          T3SS effector E3 ubiquitin-protein ligase IpaH2.5
        ipaH1.4          AF386526.1 AAL72349.2          T3SS effector E3 ubiquitin-protein ligase IpaH1.4
        stxB2            AF461173.1 AAM70046.1          Shiga toxin Stx2a subunit B
        ipaHa            AE005674.2 AAN42357.1          T3SS effector E3 ubiquitin-protein ligase IpaHa
        bimA             CP000571.1 ABN88303.1          trimeric autotransporter actin-nucleating factor BimA
        pld              CP002097.2 ADK27822.1          phospholipase D Pld
        nanH             CP020410.2 ARB89035.1          exo-alpha-sialidase NanH
        pld              AB304286.1 BAG06875.1          phospholipase D Pld
        srtB             BX248354.1 CAE48738.1          class B sortase SrtB
        spaD             BX248354.1 CAE48740.1          SpaD fimbrial major subunit SpaD
        srtC             BX248354.1 CAE48741.1          class C sortase SrtC
        spaE             BX248354.1 CAE48742.1          SpaD fimbrial minor subunit SpaE
        spaF             BX248354.1 CAE48743.1          SpaD fimbrial tip protein SpaF
        spaC             BX248359.1 CAE50541.1          SpaA fimbrial minor subunit SpaC
        spaB             BX248359.1 CAE50542.1          SpaA fimbrial minor subunit SpaB
        srtA             BX248359.1 CAE50543.1          class C sortase SrtA
        spaA             BX248359.1 CAE50544.1          SpaA fimbrial major subunit SpaA
        cbpA             BX248360.1 CAE50621.1          type I collagen-binding adhesin CbpA
        spaI             BX248360.1 CAE50750.1          SpaH fimbrial minor subunit SpaI
        srtE             BX248360.1 CAE50751.1          SpaH fimbrial biogenesis class C sortase SrtE
        srtD             BX248360.1 CAE50752.1          SpaH fimbrial biogenesis class C sortase SrtD
        spaH             BX248360.1 CAE50753.1          SpaH fimbrial major subunit SpaH
        spaG             BX248360.1 CAE50754.1          SpaH fimbrial tip protein SpaG
        cdtR             CP151682.1 WZT68956.1          LytTR family response regulator CdtR
Added point mutations
    core AMR POINT
        23S_A2062G       AZITHROMYCIN Neisseria_gonorrhoeae
        23S_C2617T       AZITHROMYCIN Neisseria_gonorrhoeae
        acrB_G288D       QUINOLONE Salmonella
        acrB_Q176K       CEPHALOSPORIN Salmonella
        blaSHV_C-112A    CEFIDEROCOL/CEPHALOSPORIN Klebsiella_pneumoniae
        cirA_Q42STOP     CEFIDEROCOL Escherichia
        dacS_E238D       VANCOMYCIN Clostridioides_difficile
        dacS_V183A       VANCOMYCIN Clostridioides_difficile
        fexA_A37V        CHLORAMPHENICOL Staphylococcus_aureus
        fexA_G33A        CHLORAMPHENICOL Staphylococcus_aureus
        folP_F31L        SULFONAMIDE Neisseria_gonorrhoeae
        folP_G194C       SULFONAMIDE Neisseria_gonorrhoeae
        folP_G194GSG     SULFONAMIDE Neisseria_gonorrhoeae
        gyrA_D93A        QUINOLONE Corynebacterium_diphtheriae
        gyrA_D93Y        QUINOLONE Corynebacterium_diphtheriae
        gyrA_S89F        QUINOLONE Corynebacterium_diphtheriae
        gyrA_S89V        QUINOLONE Corynebacterium_diphtheriae
        gyrA_S91I        QUINOLONE Neisseria_gonorrhoeae
        gyrA_S91Y        QUINOLONE Neisseria_gonorrhoeae
        liaR_E75K        DAPTOMYCIN Enterococcus_faecium
        nimB_T-35G       METRONIDAZOLE Clostridioides_difficile
        ompC_R195L       CARBAPENEM Escherichia
        parE_S458L       QUINOLONE Escherichia
        pbp5_E629V       BETA-LACTAM Enterococcus_faecium
        pbp5_M426I       BETA-LACTAM Enterococcus_faecium
        pbp5_V586L       BETA-LACTAM Enterococcus_faecium
        porB1b_A121G     BETA-LACTAM Neisseria_gonorrhoeae
        rpoB_S442F       RIFAMYCIN Corynebacterium_diphtheriae
        rpoB_S442N       RIFAMYCIN Corynebacterium_diphtheriae
        rpoB_S442Y       RIFAMYCIN Corynebacterium_diphtheriae
        rpoB_V1143L      FIDAXOMICIN Clostridioides_difficile
        rpoC_D1127E      FIDAXOMICIN Clostridioides_difficile
        rpoC_D237Y       FIDAXOMICIN Clostridioides_difficile
        rpoC_Q781R       FIDAXOMICIN Clostridioides_difficile
        rpoC_R89G        FIDAXOMICIN Clostridioides_difficile
        rpsL_K43R        STREPTOMYCIN Escherichia
        rpsL_K43T        STREPTOMYCIN Escherichia
        vanS-Cd_G339D    VANCOMYCIN Clostridioides_difficile
        vanS-Cd_R334H    VANCOMYCIN Clostridioides_difficile
        vanS-Cd_R334L    VANCOMYCIN Clostridioides_difficile
        vanS-Cd_S333F    VANCOMYCIN Clostridioides_difficile
        vanS-Cd_T369I    VANCOMYCIN Clostridioides_difficile
Removed proteins
    core AMR AMR
        crpP             NG_062203.1 WP_033179079.1     ICE-associated protein CrpP
    plus AMR AMR
        vanS-Cd          CP011847.1 AXB64455.1          VanG-Cd-type vancomycin resistance histidine kinase VanS
Changed reference gene catalog records
    ipaH3 AAN42986.1
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH3 -> T3SS effector E3 ubiquitin-protein ligase IpaH3/Hc
    ipaHd AAN43435.1
        gene_family:     ipaH2 -> ipaHd
        hierarchy_node:  ipaH2 -> ipaHd
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH2 -> T3SS effector E3 ubiquitin-protein ligase IpaHd
    ipaHd AAZ87985.1
        gene_family:     ipaH2 -> ipaHd
        hierarchy_node:  ipaH2 -> ipaHd
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH2 -> T3SS effector E3 ubiquitin-protein ligase IpaHd
    ipaH3 AAZ88030.1
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH3 -> T3SS effector E3 ubiquitin-protein ligase IpaH3/Hc
    ipaH3 ABB62096.1
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH3 -> T3SS effector E3 ubiquitin-protein ligase IpaH3/Hc
    ipaHd ABB62098.1
        gene_family:     ipaH2 -> ipaHd
        hierarchy_node:  ipaH2 -> ipaHd
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH2 -> T3SS effector E3 ubiquitin-protein ligase IpaHd
    ipaH3 ABB65884.1
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH3 -> T3SS effector E3 ubiquitin-protein ligase IpaH3/Hc
    ipaHd ABB66229.1
        gene_family:     ipaH2 -> ipaHd
        hierarchy_node:  ipaH2 -> ipaHd
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH2 -> T3SS effector E3 ubiquitin-protein ligase IpaHd
    ipaHb ABF02983.1
        gene_family:     ipaH1 -> ipaHb
        hierarchy_node:  ipaH1 -> ipaHb
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH1/H6 -> T3SS effector E3 ubiquitin-protein ligase IpaHb
    ipaHd ABF04028.1
        gene_family:     ipaH2 -> ipaHd
        hierarchy_node:  ipaH2 -> ipaHd
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH2 -> T3SS effector E3 ubiquitin-protein ligase IpaHd
    ipaH3 ACD07996.1
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH3 -> T3SS effector E3 ubiquitin-protein ligase IpaH3/Hc
    ipaHd ACD09076.1
        gene_family:     ipaH2 -> ipaHd
        hierarchy_node:  ipaH2 -> ipaHd
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH2 -> T3SS effector E3 ubiquitin-protein ligase IpaHd
    ipaH3 ADA73787.1
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH3 -> T3SS effector E3 ubiquitin-protein ligase IpaH3/Hc
    ipaHe ADA74402.1
        gene_family:     ipaH4 -> ipaHe
        hierarchy_node:  ipaH4 -> ipaHe
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH4/H7 -> T3SS effector E3 ubiquitin-protein ligase IpaHe
    ipaHa EID63069.1
        gene_family:     ipaH5 -> ipaHa
        hierarchy_node:  ipaH5 -> ipaHa
        product_name:    T3SS effector E3 ubiquitin-protein ligase IpaH5 -> T3SS effector E3 ubiquitin-protein ligase IpaHa
    aph(3')-Ia WP_000018326.1
        pubmed_reference: <empty> -> 1662755,2160941
    aph(3')-Ia WP_000018329.1
        pubmed_reference: <empty> -> 6270337
    mph(B) WP_000031017.1
        pubmed_reference: 17302923 -> 8900063,17302923
    ant(9)-Ia WP_000067268.1
        pubmed_reference: <empty> -> 2993813
    mph(E) WP_000155092.1
        pubmed_reference: 15155196,17261525 -> 15155196,17261525,18299404
    mupA WP_000163435.1
        pubmed_reference: <empty> -> 20211895
    floR WP_000214121.1
        pubmed_reference: <empty> -> 19949054
    floR WP_000214122.1
        pubmed_reference: <empty> -> 19029319
    sul1 WP_000259018.1
        pubmed_reference: <empty> -> 21537009
    sul1 WP_000259032.1
        pubmed_reference: <empty> -> 2662140
    armA WP_000359986.1
        pubmed_reference: 16626740 -> 12878520,16626740
    ant(2'')-Ia WP_000381803.1
        pubmed_reference: <empty> -> 16304199
    catA1 WP_000412211.1
        pubmed_reference: <empty> -> 390403
    aac(3)-IIe WP_000557452.1
        pubmed_reference: <empty> -> 2552900
    tet(W) WP_000691721.1
        pubmed_reference: <empty> -> 16966401
    tet(M) WP_000691727.1
        pubmed_reference: <empty> -> 19344360
    tet(M) WP_000691729.1
        pubmed_reference: <empty> -> 8595862
    tet(M) WP_000691736.1
        pubmed_reference: <empty> -> 12351239
    tet(M) WP_000691741.1
        pubmed_reference: <empty> -> 21273480
    tet(M) WP_000691743.1
        pubmed_reference: <empty> -> 17855723
    tet(O) WP_000691759.1
        pubmed_reference: <empty> -> 9124862
    sat2 WP_000704156.1
        pubmed_reference: <empty> -> 2550905
    mecA WP_000721306.1
        pubmed_reference: <empty> -> 15215121
    mecC WP_000725529.1
        pubmed_reference: <empty> -> 21636525
    blaZ WP_000733274.1
        pubmed_reference: <empty> -> 17060340
    dfrA1 WP_000777554.1
        pubmed_reference: <empty> -> 6308574
    bla2 WP_000799227.1
        pubmed_reference: <empty> -> 16621833
    tet(C) WP_000841446.1
        pubmed_reference: <empty> -> 18931093
    fusB WP_000855537.1
        pubmed_reference: <empty> -> 12205055,16842566
    rmtC WP_000855769.1
        pubmed_reference: <empty> -> 16377684
    fosB WP_000920239.1
        product_name:    FosB1/FosB3 family fosfomycin resistance bacillithiol transferase -> FosB/FosD family fosfomycin resistance bacillithiol transferase
    catB9 WP_001009012.1
        pubmed_reference: <empty> -> 11952913
    catA WP_001010387.1
        pubmed_reference: <empty> -> 6950931
    erm(B) WP_001038792.1
        pubmed_reference: 11230937 -> <empty>
    dfrA12 WP_001083725.1
        pubmed_reference: <empty> -> 16291869
    tet(B) WP_001089064.1
        pubmed_reference: <empty> -> 19528282
    tet(38) WP_001100296.1
        pubmed_reference: <empty> -> 21641281
    aadA1 WP_001206315.1
        pubmed_reference: <empty> -> 15561846
    aadA1 WP_001206316.1
        pubmed_reference: 2986186,28152054 -> 2986186,7695299,28152054
    aadA2 WP_001206356.1
        pubmed_reference: <empty> -> 22511964
    bleO WP_001242578.1
        pubmed_reference: 12654286 -> 1544435,10348769,12654286
    ant(6)-Ia WP_001255864.1
        pubmed_reference: <empty> -> 20195536
    aadE WP_001255868.1
        pubmed_reference: <empty> -> 17395262
    cmlA1 WP_001256776.1
        pubmed_reference: <empty> -> 12936998
    str WP_001258486.1
        pubmed_reference: <empty> -> 20399039
    aadA16 WP_001749984.1
        pubmed_reference: <empty> -> 25870070
    tet(A) WP_001973670.1
        pubmed_reference: <empty> -> 15528650
    tet(B) WP_002244796.1
        pubmed_reference: <empty> -> 12435724
    erm(B) WP_002292226.1
        pubmed_reference: <empty> -> 3104884
    tet(L) WP_002294500.1
        pubmed_reference: <empty> -> 12682136
    lsa(A) WP_002365053.1
        pubmed_reference: <empty> -> 12821484
    fexB WP_002415211.1
        pubmed_reference: <empty> -> 22096043
    msr(A) WP_002447408.1
        pubmed_reference: <empty> -> 10564793
    catA WP_002489529.1
        pubmed_reference: <empty> -> 3855295,3860383
    aph(3')-IIb WP_003132309.1
        pubmed_reference: <empty> -> 8723476
    tet(L) WP_003242953.1
        pubmed_reference: <empty> -> 2844262
    tet(32) WP_003505402.1
        pubmed_reference: <empty> -> 18955517
    tet(W) WP_003672618.1
        pubmed_reference: <empty> -> 18689509
    cmlR WP_003971483.1
        pubmed_reference: <empty> -> 1779766
    tet(Q) WP_004293868.1
        pubmed_reference: <empty> -> 1339256
    tet(M) WP_004632336.1
        pubmed_reference: <empty> -> 3020504
    blaA WP_005165780.1
        pubmed_reference: <empty> -> 1886608
    ampC WP_006178946.1
        pubmed_reference: <empty> -> 12393205
    erm(C) WP_007410443.1
        pubmed_reference: 6938954 -> 6162157,6279574,6938954
    tet(40) WP_009247026.1
        pubmed_reference: <empty> -> 23292102
    tet(W) WP_009305318.1
        pubmed_reference: <empty> -> 16936047
    erm(E) WP_009950391.1
        pubmed_reference: <empty> -> 2335200
    aph(3')-Id WP_010891085.1
        pubmed_reference: 2653965 -> 2653965,7640311
    cpt WP_010982315.1
        pubmed_reference: <empty> -> 12692562
    sul2 WP_011011113.1
        pubmed_reference: <empty> -> 11815584
    aph(3')-Ia WP_011039766.1
        pubmed_reference: <empty> -> 2013575,2989253,3277947,12029035
    erm(T) WP_011100845.1
        pubmed_reference: <empty> -> 14597008
    cmx WP_011113071.1
        pubmed_reference: <empty> -> 16890319
    tet(M) WP_011117014.1
        pubmed_reference: <empty> -> 12383727
    catA1 WP_011152976.1
        pubmed_reference: <empty> -> 15518875
    aph(6)-Id WP_011161217.1
        pubmed_reference: <empty> -> 14711528
    rox WP_011210071.1
        pubmed_reference: <empty> -> 15466710
    aadA2 WP_011222095.1
        pubmed_reference: <empty> -> 15528648
    floR WP_011266118.1
        pubmed_reference: <empty> -> 15814600
    erm(C) WP_011276921.1
        pubmed_reference: <empty> -> 16237012
    aadA5 WP_011342946.1
        pubmed_reference: <empty> -> 16122561
    erm(C) WP_011382144.1
        pubmed_reference: <empty> -> 16487670
    blaS WP_011728509.1
        pubmed_reference: <empty> -> 15699201
    catA2 WP_011751353.1
        pubmed_reference: <empty> -> 12650243
    blaA WP_011816299.1
        pubmed_reference: <empty> -> 17173484
    tet(M) WP_011860841.1
        pubmed_reference: <empty> -> 16804543
    floR WP_011931116.1
        pubmed_reference: <empty> -> 18413319
    tet(H) WP_012209823.1
        pubmed_reference: <empty> -> 10913704
    bla2 WP_012261328.1
        pubmed_reference: <empty> -> 17434157
    mupA WP_012263521.1
        pubmed_reference: <empty> -> 8067768
    tet(L) WP_012290101.1
        pubmed_reference: <empty> -> 18192429
    sul1 WP_012312004.1
        pubmed_reference: <empty> -> 17827139
    aph(3'')-Ia WP_012377648.1
        pubmed_reference: <empty> -> 18310036,18375553
    catA WP_012406403.1
        pubmed_reference: <empty> -> 19091524
    aadA13 WP_012414180.1
        pubmed_reference: <empty> -> 18268088
    catB2 WP_012477387.1
        pubmed_reference: <empty> -> 12089302
    aph(3')-Ia WP_012477822.1
        pubmed_reference: <empty> -> 17485180
    floR WP_012561099.1
        pubmed_reference: <empty> -> 18786941
    vga(A) WP_012579073.1
        pubmed_reference: <empty> -> 20876620
    tet(A) WP_012579085.1
        pubmed_reference: <empty> -> 18812424
    aac(6')-Ie/aph(2'')-Ia WP_012655884.1
        pubmed_reference: <empty> -> 19074389
    dfrK WP_012779617.1
        pubmed_reference: <empty> -> 19470508
    aac(6')-Ib WP_013250882.1
        pubmed_reference: <empty> -> 12936982
    tet(O/W/32/O) WP_013646121.1
        pubmed_reference: <empty> -> 22710115
    mph(E) WP_014325835.1
        pubmed_reference: 15155196,17261525 -> 15155196,17261525,21709086
    floR WP_014386424.1
        pubmed_reference: <empty> -> 11451703
    mph(G) WP_014386803.1
        pubmed_reference: 25765542 -> 22446310,25765542
    apmA WP_015059965.1
        pubmed_reference: <empty> -> 22718530
    aac(3)-IIe WP_015060297.1
        pubmed_reference: <empty> -> 19055690
    tet(L) WP_015060376.1
        pubmed_reference: <empty> -> 21057017
    blaBJP WP_015684602.1
        pubmed_reference: <empty> -> 22452844
    floR WP_021038045.1
        pubmed_reference: <empty> -> 14645321
    aac(6')-Ib WP_022631510.1
        pubmed_reference: <empty> -> 22547620
    vanR-D WP_023043165.1
        pubmed_reference: <empty> -> 12499162
    blaP WP_023857755.1
        pubmed_reference: <empty> -> 6269055
    tet(M) WP_024052575.1
        pubmed_reference: <empty> -> 19531603
    mphN WP_024127776.1
        pubmed_reference: 24362420 -> <empty>
    mef(A) WP_024127829.1
        pubmed_reference: <empty> -> 24362420
    tet(W/N/W) WP_024963478.1
        pubmed_reference: <empty> -> 11959557
    catB WP_031281281.1
        pubmed_reference: <empty> -> 22547620
    dfrK WP_031775848.1
        pubmed_reference: <empty> -> 20498309
    vga(E) WP_031795517.1
        class:           LINCOSAMIDE -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE -> CLINDAMYCIN/LINCOMYCIN/RETAPAMULIN/VIRGINIAMYCIN
    tet(A) WP_031942321.1
        pubmed_reference: <empty> -> 18029415
    aadA1 WP_031942898.1
        pubmed_reference: <empty> -> 22279444
    erm(X) WP_032488331.1
        pubmed_reference: 2110657 -> 1446073,2110657
    tet(L) WP_032488409.1
        pubmed_reference: <empty> -> 1622166
    catA WP_032488460.1
        pubmed_reference: <empty> -> 3865770
    catA WP_032488466.1
        pubmed_reference: <empty> -> 1517170
    dfrA14 WP_032488755.1
        pubmed_reference: <empty> -> 7706167
    tet(B) WP_032490133.1
        pubmed_reference: <empty> -> 11557485
    tet(E) WP_032490168.1
        pubmed_reference: <empty> -> 1622171
    aph(3'')-Ib WP_032490182.1
        pubmed_reference: <empty> -> 12029529
    catA WP_032490319.1
        pubmed_reference: <empty> -> 12732947
    tet(O) WP_032490535.1
        pubmed_reference: <empty> -> 15603835
    aac(6')-Ie/aph(2'')-Ia WP_032490744.1
        pubmed_reference: <empty> -> 12716781
    sul2 WP_032490786.1
        pubmed_reference: <empty> -> 12937006
    sul1 WP_032490976.1
        pubmed_reference: <empty> -> 15743901
    lnu(A) WP_032491106.1
        pubmed_reference: <empty> -> 15212891
    sul1 WP_032491228.1
        pubmed_reference: <empty> -> 15728925
    dfrA16 WP_032491316.1
        pubmed_reference: <empty> -> 15917562
    aac(3)-Ia WP_032491356.1
        pubmed_reference: 9835490 -> 9169202,9835490
    sul1 WP_032491570.1
        pubmed_reference: <empty> -> 16436717
    fexA WP_032491576.1
        pubmed_reference: <empty> -> 16569824
    fexA WP_032491881.1
        pubmed_reference: <empty> -> 17145796
    sul1 WP_032492024.1
        pubmed_reference: <empty> -> 18993034
    aph(3')-Ia WP_032492145.1
        pubmed_reference: <empty> -> 21393370
    catB3 WP_032492194.1
        pubmed_reference: <empty> -> 18515416
    erm(C) WP_032492416.1
        pubmed_reference: <empty> -> 19457037
    aadA1 WP_032492486.1
        pubmed_reference: <empty> -> 19427174
    vga(A) WP_032492560.1
        pubmed_reference: <empty> -> 21549571
    aph(3')-XV WP_032492579.1
        pubmed_reference: <empty> -> 20368407
    aadA1 WP_032492580.1
        pubmed_reference: <empty> -> 20368407
    catB3 WP_032492683.1
        pubmed_reference: <empty> -> 12654674
    vga(E) WP_032495718.1
        class:           LINCOSAMIDE -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN
        pubmed_reference: <empty> -> 24324222
        subclass:        LINCOSAMIDE -> CLINDAMYCIN/LINCOMYCIN/RETAPAMULIN/VIRGINIAMYCIN
    dfrA22 WP_032667553.1
        pubmed_reference: <empty> -> 15715715
    fomB WP_033205177.1
        pubmed_reference: 18701452 -> 7500951,18701452
    aadD2 WP_035202393.1
        pubmed_reference: <empty> -> 12654668,17846134
    aac(3)-Id WP_038404949.1
        pubmed_reference: <empty> -> 15117923
    vanB WP_042958124.1
        pubmed_reference: <empty> -> 15057465
    tet(M) WP_043029018.1
        pubmed_reference: <empty> -> 18439362
    aac(6')-31 WP_044424439.1
        pubmed_reference: <empty> -> 17470660
    aac(6')-IIc WP_045332676.1
        pubmed_reference: <empty> -> 27965456
    mecA1 WP_048540464.1
        pubmed_reference: <empty> -> 9158816
    erm(N) WP_050364506.1
        pubmed_reference: 30023575 -> 8973363,30023575
    erm(42) WP_052259183.1
        pubmed_reference: <empty> -> 21371136
    tet(O/W/O) WP_054336482.1
        pubmed_reference: <empty> -> 12839756
    erm(30) WP_055641627.1
        pubmed_reference: 9770448 -> <empty>
    mef(A) WP_058621816.1
        pubmed_reference: <empty> -> 16431859
    aac(3)-Ia WP_063840258.1
        pubmed_reference: <empty> -> 16495246
    aac(3)-Ia WP_063840259.1
        pubmed_reference: <empty> -> 21117966
    aac(3)-I WP_063840260.1
        pubmed_reference: <empty> -> 21281423
    aac(3)-IIa WP_063840264.1
        pubmed_reference: <empty> -> 3892230
    aac(3)-VIII WP_063840270.1
        pubmed_reference: <empty> -> 15827636
    aac(3)-VIII WP_063840271.1
        pubmed_reference: <empty> -> 16258246
    aac(6')-Il WP_063840324.1
        pubmed_reference: <empty> -> 20617927
    aadA3 WP_063840442.1
        pubmed_reference: <empty> -> 19131424
    aadA9 WP_063840459.1
        pubmed_reference: <empty> -> 21097590
    aadD1 WP_063840460.1
        pubmed_reference: <empty> -> 3003740
    aadD1 WP_063840461.1
        pubmed_reference: <empty> -> 10544290,11602251
    blaSRT WP_063840465.1
        pubmed_reference: <empty> -> 14982755
    aph(3')-Ia WP_063841683.1
        pubmed_reference: <empty> -> 2823223
    bla WP_063842272.1
        pubmed_reference: <empty> -> 21281423
    bla WP_063842277.1
        pubmed_reference: <empty> -> 21281423
    blaL1 WP_063842699.1
        pubmed_reference: <empty> -> 18086856
    blaL2 WP_063842700.1
        pubmed_reference: 18212097 -> 18212097,20397035
    blaOCH WP_063842730.1
        pubmed_reference: <empty> -> 11389106
    blaOKP-B WP_063842745.1
        pubmed_reference: <empty> -> 16769193
    blaZ WP_063842862.1
        pubmed_reference: <empty> -> 23274660
    blaR1 WP_063842869.1
        pubmed_reference: <empty> -> 12384372
    blaSED WP_063842905.1
        pubmed_reference: <empty> -> 8064842
    ble-Sh WP_063842998.1
        pubmed_reference: <empty> -> 1695734
    catB3 WP_063843225.1
        pubmed_reference: <empty> -> 17908616
    catB3 WP_063843226.1
        pubmed_reference: <empty> -> 17897793
    catB8 WP_063843232.1
        pubmed_reference: <empty> -> 22127350
    catD WP_063843233.1
        pubmed_reference: <empty> -> 2748343
    cepH WP_063843234.1
        pubmed_reference: <empty> -> 11062187
    cepS WP_063843235.1
        pubmed_reference: 11062187 -> 8537283,11062187
    cmlA4 WP_063843247.1
        pubmed_reference: <empty> -> 15761062
    dfrA WP_063844288.1
        pubmed_reference: <empty> -> 10990262
    dfrA1 WP_063844290.1
        pubmed_reference: <empty> -> 12493806
    dfrA1 WP_063844293.1
        pubmed_reference: <empty> -> 16585655
    dfrA12 WP_063844297.1
        pubmed_reference: <empty> -> 15145503
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    blaPDC-33 WP_012074328.1
        pubmed_reference: <empty> -> 20107499
    blaPER-10 WP_001100752.1
        pubmed_reference: <empty> -> 26195261
    blaPLA-2a WP_047664983.1
        pubmed_reference: <empty> -> 14693555
    blaPLN-1 WP_041884311.1
        pubmed_reference: <empty> -> 25814603
    blaPNGM-1 WP_148044471.1
        product_name:    subclass B3-like metallo-beta-lactamase PNGM-1 -> beta-lactam-hydrolyzing MBL fold hydrolase PNGM-1
    blaPOM-1 WP_044403015.1
        pubmed_reference: <empty> -> 21060106
    blaPST-1 WP_043942497.1
        pubmed_reference: <empty> -> 29020980
    blaRAHN-2 WP_063864601.1
        pubmed_reference: <empty> -> 20511369
    blaSCO-1 WP_004197546.1
        pubmed_reference: <empty> -> 17420213
    blaSFC-1 WP_024531321.1
        pubmed_reference: 15155245 -> 15155245,17875998
    blaSGM-3 WP_007688792.1
        pubmed_reference: <empty> -> 22843598
    blaSHV-115 WP_156404661.1
        product_name:    extended-spectrum class A beta-lactamase SHV-115 -> class A beta-lactamase SHV-115
        subclass:        CEPHALOSPORIN -> BETA-LACTAM
    blaSHV-122b WP_223146970.1
        pubmed_reference: <empty> -> 21359845
    blaSHV-129 WP_032494802.1
        product_name:    extended-spectrum class A beta-lactamase SHV-129 -> inhibitor-resistant extended-spectrum class A beta-lactamase SHV-129
        pubmed_reference: 22322349 -> 22322349,25691639
    blaSHV-141 WP_063864626.1
        product_name:    broad-spectrum class A beta-lactamase SHV-141 -> extended-spectrum class A beta-lactamase SHV-141
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-187 WP_021440083.1
        product_name:    extended-spectrum class A beta-lactamase SHV-187 -> broad-spectrum class A beta-lactamase SHV-187
    blaSHV-200 WP_096807447.1
        product_name:    class A beta-lactamase SHV-200 -> extended-spectrum class A beta-lactamase SHV-200
        pubmed_reference: <empty> -> 30461373
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-203 WP_099156054.1
        product_name:    class A beta-lactamase SHV-203 -> inhibitor-resistant extended-spectrum class A beta-lactamase SHV-203
        pubmed_reference: <empty> -> 32284385,32351477
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-230 WP_268871888.1
        product_name:    class A beta-lactamase SHV-230 -> extended-spectrum class A beta-lactamase SHV-230
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-231 WP_268871889.1
        product_name:    class A beta-lactamase SHV-231 -> inhibitor-resistant extended-spectrum class A beta-lactamase SHV-231
        pubmed_reference: <empty> -> 25691639,32351477
    blaSHV-232 WP_087834333.1
        pubmed_reference: <empty> -> 37668148
    blaSHV-233 WP_328703073.1
        pubmed_reference: <empty> -> 25691639
    blaSHV-238 WP_328703078.1
        product_name:    class A beta-lactamase SHV-238 -> inhibitor-resistant extended-spectrum class A beta-lactamase SHV-238
        pubmed_reference: <empty> -> 25691639
    blaSHV-26 WP_023280043.1
        product_name:    inhibitor-resistant broad-spectrum class A beta-lactamase SHV-26 -> broad-spectrum class A beta-lactamase SHV-26
        pubmed_reference: 11502506 -> 11502506,36358219
    blaSHV-35 WP_063864677.1
        pubmed_reference: 15047521 -> 15047521,32005138
    blaSHV-65 WP_063864699.1
        product_name:    extended-spectrum class A beta-lactamase SHV-65 -> broad-spectrum class A beta-lactamase SHV-65
    blaSHV-73 WP_063864705.1
        product_name:    broad-spectrum class A beta-lactamase SHV-73 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-73
        pubmed_reference: 19272757 -> 19272757,25691639
    blaSHV-97 WP_063864719.1
        product_name:    extended-spectrum class A beta-lactamase SHV-97 -> inhibitor-resistant extended-spectrum class A beta-lactamase SHV-97
    blaSIE-1 WP_007683232.1
        pubmed_reference: <empty> -> 22843598
    blaSPM-1 WP_063864747.1
        pubmed_reference: 37255469 -> 12407123,37255469
    blaSPS-1 WP_013255389.1
        pubmed_reference: <empty> -> 21304743
    blaTEM-183 WP_063864881.1
        pubmed_reference: <empty> -> 21752977
    blaTEM-213 WP_055314508.1
        pubmed_reference: <empty> -> 28636609
    blaTEM-235 WP_110174956.1
        pubmed_reference: <empty> -> 19713526
    blaTTU-1 WP_015818996.1
        pubmed_reference: <empty> -> 19568419
    blaVEB-13 WP_063865153.1
        pubmed_reference: <empty> -> 26926646
    blaVEB-15 WP_063865155.1
        pubmed_reference: <empty> -> 26926646
    blaVIM-83 WP_262697195.1
        product_name:    subclass B1 metallo-beta-lactamase VIM-83 -> taniborbactam-resistant subclass B1 metallo-beta-lactamase VIM-83
        pubmed_reference: <empty> -> 38727224
        subclass:        CARBAPENEM -> CARBAPENEM/TANIBORBACTAM
    cfiA11 WP_063843236.1
        pubmed_reference: <empty> -> 20226324
    cfiA14 WP_005780969.1
        pubmed_reference: <empty> -> 12149371
    cfiA17 WP_085562389.1
        pubmed_reference: <empty> -> 28414107
    cfiA18 WP_085562388.1
        pubmed_reference: <empty> -> 28414107
    cfiA19 WP_085562383.1
        pubmed_reference: <empty> -> 28414107
    cfiA21 WP_085562390.1
        pubmed_reference: <empty> -> 28414107
    cfiA22 WP_085562385.1
        pubmed_reference: <empty> -> 28414107
    cfiA23 WP_085562386.1
        pubmed_reference: <empty> -> 28414107
    cfiA24 WP_085562387.1
        pubmed_reference: <empty> -> 28414107
    cfiA9 WP_063865207.1
        pubmed_reference: 12604530 -> 12604530,20226324
    cls_NFQ77del WP_002413481.1
        pubmed_reference: <empty> -> 23959318
    cls_R218Q WP_002413481.1
        pubmed_reference: <empty> -> 23959318
    cmlA10 WP_042862943.1
        pubmed_reference: <empty> -> 20002132
    dfrB6 WP_063844479.1
        pubmed_reference: 16870788 -> 7695299,16870788
    dfrS1 WP_000175735.1
        pubmed_reference: <empty> -> 20547176
    ere(A2) WP_032490534.1
        pubmed_reference: <empty> -> 14506050
    folP_R171P WP_000764713.1
        pubmed_reference: 37906281,37906281 -> 37906281
    fosB WP_032488468.1
        pubmed_reference: <empty> -> 1804759,2341025
    ftsI_I336IKYRI WP_000642196.1
        pubmed_reference: 29061754,25634992,32988825 -> 25634992,29061754,32988825,38661186
        subclass:        AZTREONAM -> AZTREONAM/CEFIDEROCOL/CEPHALOSPORIN
    ftsI_N337NYRIN WP_000642196.1
        pubmed_reference: 25634992,32988825,37610183 -> 25634992,32988825,37610183,38661186
        subclass:        AZTREONAM/CEFIDEROCOL -> AZTREONAM/CEFIDEROCOL/CEPHALOSPORIN
    gyrA_D87G WP_001281243.1
        pubmed_reference: 8849244,8891148,14506034,9988045,29091182,9756773,8849244,8891148,14506034,9988045 -> 8849244,8891148,9756773,9988045,14506034,29091182
    gyrA_G81D WP_001281243.1
        pubmed_reference: 8392306,8392306 -> 8392306
    liaF_R177del WP_002381168.1
        pubmed_reference: <empty> -> 21899450,23507277,23959318
    liaR_D191N WP_002355137.1
        pubmed_reference: <empty> -> 23959318
    liaR_W73C WP_002289153.1
        pubmed_reference: <empty> -> 22664970
    liaS_T120A WP_002289154.1
        pubmed_reference: <empty> -> 22664970
    mcr-1.26 WP_034169413.1
        pubmed_reference: <empty> -> 32908612
    mcr-1.27 WP_163397051.1
        pubmed_reference: <empty> -> 32908612
    mcr-4.4 WP_109545055.1
        pubmed_reference: <empty> -> 29635007
    mcr-4.5 WP_109545054.1
        pubmed_reference: <empty> -> 29635007
    oprD_Q142STOP WP_003112576.1
        pubmed_reference: 27736752,29681898,37823665,37823665 -> 27736752,29681898,37823665
    oqxB20 WP_021312368.1
        pubmed_reference: <empty> -> 25520451
    oqxB29 WP_063501636.1
        pubmed_reference: <empty> -> 25520451
    parC_S80I WP_001281881.1
        pubmed_reference: 8849244,8891148,14506034,11699598,14506034,14706091 -> 8849244,8891148,11699598,14506034,14706091
    pmrB_G188D WP_003112923.1
        pubmed_reference: 22106224,22106224 -> 22106224
    qepA1 WP_012372821.1
        pubmed_reference: <empty> -> 17548499
    qnrB17 WP_048216435.1
        pubmed_reference: <empty> -> 21844311,24629900
    qnrB2 WP_012695489.1
        pubmed_reference: <empty> -> 16569827
    rmtB1 WP_012372818.1
        pubmed_reference: <empty> -> 14742200
    rmtF1 WP_015632396.1
        pubmed_reference: <empty> -> 22547620
    rpoB_Q1074R WP_003436174.1
        pubmed_reference: 23887866 -> 23887866,38598696
    tmexC3 WP_034039546.1
        pubmed_reference: <empty> -> 33875423
    tmexD3 WP_034065037.1
        pubmed_reference: <empty> -> 33875423

Hierarchy nodes Added
    core AMR AMR
        aadA33           aadA33                         ANT(3'')-I family aminoglycoside nucleotidyltransferase AadA33
        aadA36           aadA36                         ANT(3'')-I family aminoglycoside nucleotidyltransferase AadA36
        blaBMHC          blaBMHC NF045721.1             BMHC family subclass B1 metallo-beta-lactamase
        dfrA49           dfrA49                         trimethoprim-resistant dihydrofolate reductase DfrA49
        dfrA50           dfrA50 NF047323.1              trimethoprim-resistant dihydrofolate reductase DfrA50
        dfrA51           dfrA51 NF047324.1              trimethoprim-resistant dihydrofolate reductase DfrA51
        pbp2m            pbp2m                          penicillin-binding protein PBP2M
    non-reported VIRULENCE VIRULENCE
        VIRULENCE_Cdiphth
    plus VIRULENCE VIRULENCE
        bimA_Bm          bimA                           trimeric autotransporter actin-nucleating factor BimA
        cbpA             cbpA                           type I collagen-binding adhesin CbpA
        cdtR             cdtR                           LytTR family response regulator CdtR
        ipaH1.4          ipaH1.4                        T3SS effector E3 ubiquitin-protein ligase IpaH1.4
        ipaH2.5          ipaH2.5                        T3SS effector E3 ubiquitin-protein ligase IpaH2.5
        ipaH4.5          ipaH4.5                        T3SS effector E3 ubiquitin-protein ligase IpaH4.5
        ipaH7.8          ipaH7.8                        T3SS effector E3 ubiquitin-protein ligase IpaH7.8
        ipaH_Shig        ipaH NF046045.1                IpaH family T3SS effector E3 ubiquitin-protein ligase
        ipaHa            ipaHa                          T3SS effector E3 ubiquitin-protein ligase IpaHa
        ipaHb            ipaHb                          T3SS effector E3 ubiquitin-protein ligase IpaHb
        ipaHd            ipaHd                          T3SS effector E3 ubiquitin-protein ligase IpaHd
        ipaHe            ipaHe                          T3SS effector E3 ubiquitin-protein ligase IpaHe
        nanH             nanH                           exo-alpha-sialidase NanH
        pld              pld                            phospholipase D Pld
        spaA             spaA                           SpaA fimbrial major subunit SpaA
        spaB             spaB                           SpaA fimbrial minor subunit SpaB
        spaC             spaC                           SpaA fimbrial minor subunit SpaC
        spaD             spaD                           SpaD fimbrial major subunit SpaD
        spaE             spaE                           SpaD fimbrial minor subunit SpaE
        spaF             spaF                           SpaD fimbrial tip protein SpaF
        spaG             spaG                           SpaH fimbrial tip protein SpaG
        spaH             spaH                           SpaH fimbrial major subunit SpaH
        spaI             spaI                           SpaH fimbrial minor subunit SpaI
        srtA             srtA                           class C sortase SrtA
        srtB             srtB                           class B sortase SrtB
        srtC             srtC                           class C sortase SrtC
        srtD             srtD                           SpaH fimbrial biogenesis class C sortase SrtD
        srtE             srtE                           SpaH fimbrial biogenesis class C sortase SrtE
        tox              tox                            diphtheria toxin Tox
Hierarchy nodes Removed
    plus VIRULENCE VIRULENCE
        ipaH1            ipaH1                          T3SS effector E3 ubiquitin-protein ligase IpaH1/H6
        ipaH2            ipaH2                          T3SS effector E3 ubiquitin-protein ligase IpaH2
        ipaH4            ipaH4                          T3SS effector E3 ubiquitin-protein ligase IpaH4/H7
        ipaH5            ipaH5                          T3SS effector E3 ubiquitin-protein ligase IpaH5
        ipa_gen          ipa                            T3SS effector E3 ubiquitin-protein ligase
Changed Hierarchy Nodes
    blaAFM           AFM family subclass B1 metallo-beta-lactamase
        hmm_acc:         NF033736.1 -> NF033736.2
    crpP             ICE-associated protein CrpP
        scope:           core -> plus
    ipaH3            T3SS effector E3 ubiquitin-protein ligase IpaH3/Hc
        name:            T3SS effector E3 ubiquitin-protein ligase IpaH3 -> T3SS effector E3 ubiquitin-protein ligase IpaH3/Hc
        parent_node_id:  ipa_gen -> ipaH_Shig
    ipaH9.8          T3SS effector E3 ubiquitin-protein ligase IpaH9.8
        parent_node_id:  ipa_gen -> ipaH_Shig
    vga(E)           ABC-F type ribosomal protection protein Vga(E)
        class:           LINCOSAMIDE -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE -> CLINDAMYCIN/LINCOMYCIN/RETAPAMULIN/VIRGINIAMYCIN


----------------------------------------------------------------------
Changes included in 2024-05-02.2
----------------------------------------------------------------------

In addition to the usual addition of new alleles and genes there were several
major changes in this release.

- Many updates to HMMs and hierarchy structure based on a review of HMMs and
  new QC checks.
- Extensive Shiga toxin gene (Stx) curation and changes in how Stx proteins are
  reported. Some reference accessions were removed and others added to
  harmonize our references with other databases. These changes are part of a
  collaboration to better characterize and standardize Stx subtype
  nomenclature, and are in preparation for a manuscript and tool to correctly
  assign known Stx subtypes. We are no longer including a subtype for each of
  the Stx proteins since it can be misleading because many of the subunit
  proteins can be part of multiple Stx subtypes. That information can still be
  found in the Subclass and Protein name fields.
- Collaboration with Gen-FS Salmonella Virulence Factor Working group members
  resulted in curator review and addition of 8 virulence genes for Salmonella
  based on Harhay et al., 2024 (protocols.io;
  https://dx.doi.org/10.17504/protocols.io.6qpvr3on3vmk/v1).
- The blaOXA-18 reference was replaced to correct an early start. The new
  reference is 6-amino acids shorter.
- For this release, we removed the HMM NF000355. That HMM is useful because it
  finds most or all known examples of ABC-F family ribosomal protection
  proteins. However, the family is sufficiently broad now that the family
  includes some number of ABC-F family proteins with roles other than
  antibiotic resistance through the ribosomal protection mechanism. Sensitivity
  for members of the known individual families of ribosomal protection proteins
  should be unaffected. Identification of candidate new ribosomal protection
  proteins, based on hits to the HMM NF000355, is still possible by examination
  of RefSeq annotation, but not directly by use of the new version of
  AMRFinderPlus. In upcoming releases, we plan to build new HMMs for
  non-overlapping subfamilies of members of family NF000355, so identification
  of potential novel families of ribosomal protection proteins can be performed
  with less risk of false-positive identifications.
- Some product name cleanup for point mutation reference genes.
- For consistency, we have changed the gene symbol for point mutations from
  50S_L22 to rplV. In Pathogen Detection data, isolates that have not been
  processed recently could be referred to as "50S_L22" and should be viewed as
  equivalent.
- New Escherichia, Salmonella, Streptococcus pneumonieae, and Enterococcus
  faecium point mutations.
- Updated Protein name and subclass for several genes due to new information on
  phenotypes found in the literature.
- Sequences for aalE and cstB were found to be incorrect and were replaced.

Summary:
   Total proteins: 8180
        Core proteins: 6941
        Plus proteins: 1236
   AMR proteins: 6990
   STRESS proteins: 257
   VIRULENCE proteins: 933
   PubMed references: 4456
   Point mutations: 1309
   Point mutation reference sequences: 234
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae,
       Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae,
       Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens,
       Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes, Vibrio_cholerae,
       Vibrio_parahaemolyticus, Vibrio_vulnificus
   HMMs: 743

Updates since release 2024-01-31.1:
   Proteins added: 145
       Core proteins added: 76
       Plus proteins added: 69
   AMR proteins added: 79
   STRESS proteins added: 4
   VIRULENCE proteins added: 62
   Alleles added: 73
   PubMed references added: 78
   PubMed references removed: 4
   Point mutations added: 30
   Proteins removed: 16
       Core proteins removed: 1
       Plus proteins removed: 15
   Point mutations removed 11
   Reference Gene Catalog entries changed: 270
   Hierarchy nodes added: 51
   Hierarchy nodes removed: 3
   Hierarchy nodes changed: 62

Added proteins
    core AMR AMR
        lnu(I)           NG_242532.1 WP_008992950.1     lincosamide nucleotidyltransferase Lnu(I)
        tet(65)          NG_242533.1 WP_152609570.1     tetracycline efflux MFS transporter Tet(65)
        vga(F)           NG_242534.1 WP_172065992.1     ABC-F type ribosomal protection protein Vga(F)
        cmeB             NG_242531.1 WP_254563251.1     multidrug efflux RND transporter permease subunit CmeB, ciprofloxacin and florfenicol resistance type
        blaADC-347       NG_242535.1 WP_138149148.1     extended-spectrum class C beta-lactamase ADC-347
        blaADC-348       NG_242536.1 WP_096877503.1     extended-spectrum class C beta-lactamase ADC-348
        blaADC-349       NG_242537.1 WP_334264835.1     extended-spectrum class C beta-lactamase ADC-349
        blaADC-350       NG_242538.1 WP_016804156.1     extended-spectrum class C beta-lactamase ADC-350
        blaADC-351       NG_242539.1 WP_338424097.1     extended-spectrum class C beta-lactamase ADC-351
        blaADC-352       NG_242540.1 WP_338424098.1     extended-spectrum class C beta-lactamase ADC-352
        blaADC-353       NG_242541.1 WP_338424099.1     extended-spectrum class C beta-lactamase ADC-353
        blaCMY-188       NG_242543.1 WP_338424100.1     class C beta-lactamase CMY-188
        blaCMY-189       NG_242544.1 WP_046670810.1     class C beta-lactamase CMY-189
        blaDYB-1         NG_242545.1 WP_338373280.1     subclass B1 metallo-beta-lactamase DYB-1
        blaIMI-25        NG_242546.1 WP_320734326.1     carbapenem-hydrolyzing class A beta-lactamase IMI-25
        blaIMI-26        NG_242547.1 WP_320735136.1     carbapenem-hydrolyzing class A beta-lactamase IMI-26
        blaIMI-27        NG_242548.1 WP_111966200.1     carbapenem-hydrolyzing class A beta-lactamase IMI-27
        blaKHM-2         NG_242549.1 WP_338424101.1     subclass B1 metallo-beta-lactamase KHM-2
        blaKPC-169       NG_242550.1 WP_338424102.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-169
        blaKPC-171       NG_242551.1 WP_338424103.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-171
        blaKPC-172       NG_242552.1 WP_338424104.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-172
        blaKPC-173       NG_242553.1 WP_338424105.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-173
        blaKPC-174       NG_242554.1 WP_338424106.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-174
        blaKPC-175       NG_242555.1 WP_338424107.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-175
        blaKPC-177       NG_242556.1 WP_338424108.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-177
        blaKPC-209       NG_242557.1 WP_338424109.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-209
        blaKPC-211       NG_242558.1 WP_336433394.1     carbapenem-hydrolyzing class A beta-lactamase KPC-211
        blaKPC-212       NG_242559.1 WP_336434105.1     carbapenem-hydrolyzing class A beta-lactamase KPC-212
        blaKPC-213       NG_242560.1 WP_336464807.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-213
        blaKPC-214       NG_242561.1 WP_336433450.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-214
        blaKPC-215       NG_242562.1 WP_336433517.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-215
        blaKPC-216       NG_242563.1 WP_338424110.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-216
        blaMUN-1         NG_242564.1 WP_206340447.1     MUN family extended-spectrum class A beta-lactamase MUN-1
        blaMUN-2         NG_242565.1 WP_254887308.1     MUN family extended-spectrum class A beta-lactamase MUN-2
        blaMUN-3         NG_242566.1 WP_234225171.1     MUN family extended-spectrum class A beta-lactamase MUN-3
        blaMUN-4         NG_242567.1 WP_224206459.1     MUN family extended-spectrum class A beta-lactamase MUN-4
        blaMUN-5         NG_242568.1 WP_254888401.1     MUN family extended-spectrum class A beta-lactamase MUN-5
        blaMUN-6         NG_242569.1 WP_258885795.1     MUN family extended-spectrum class A beta-lactamase MUN-6
        blaNDM-64        NG_242571.1 WP_338424111.1     subclass B1 metallo-beta-lactamase NDM-64
        blaNDM-65        NG_242572.1 WP_338424112.1     subclass B1 metallo-beta-lactamase NDM-65
        blaNDM-66        NG_242573.1 WP_336187019.1     subclass B1 metallo-beta-lactamase NDM-66
        blaNDM-67        NG_242574.1 WP_338424113.1     subclass B1 metallo-beta-lactamase NDM-67
        blaNDM-68        NG_242575.1 WP_338424114.1     subclass B1 metallo-beta-lactamase NDM-68
        blaOXA-1226      NG_242576.1 WP_338424115.1     OXA-48 family class D beta-lactamase OXA-1226
        blaOXA-1227      NG_242577.1 WP_338424116.1     OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1227
        blaOXA-1228      NG_242578.1 WP_338424117.1     OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1228
        blaOXA-1229      NG_242579.1 WP_338424118.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1229
        blaOXA-1230      NG_242580.1 WP_338424119.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1230
        blaOXA-1231      NG_242581.1 WP_338424120.1     OXA-10 family class D beta-lactamase OXA-1231
        blaOXA-1232      NG_242582.1 WP_338424121.1     OXA-10 family class D beta-lactamase OXA-1232
        blaOXA-1233      NG_242583.1 WP_338424122.1     OXA-10 family class D beta-lactamase OXA-1233
        blaOXA-1234      NG_242584.1 WP_338424123.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1234
        blaOXA-1235      NG_242585.1 WP_338424124.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1235
        blaOXA-1236      NG_242586.1 WP_338424125.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1236
        blaOXA-1237      NG_242587.1 WP_334377767.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1237
        blaOXA-1238      NG_242588.1 WP_338424126.1     class D beta-lactamase OXA-1238
        blaOXA-1239      NG_242589.1 WP_338424127.1     carbapenem-hydrolyzing class D beta-lactamase OXA-1239
        blaOXA-1240      NG_242590.1 WP_338424128.1     OXA-48 family class D beta-lactamase OXA-1240
        blaOXA-18        NG_049480.2 WP_277915723.1     extended-spectrum class D beta-lactamase OXA-18
        blaPAM-5         NG_242592.1 WP_184489348.1     subclass B3 metallo-beta-lactamase PAM-5
        blaPDC-582       NG_242593.1 WP_338424129.1     class C beta-lactamase PDC-582
        blaPDC-583       NG_242594.1 WP_338424130.1     class C beta-lactamase PDC-583
        blaPDC-584       NG_242595.1 WP_338424131.1     class C beta-lactamase PDC-584
        blaPDC-585       NG_242596.1 WP_338424132.1     class C beta-lactamase PDC-585
        blaPDC-586       NG_242597.1 WP_338424133.1     class C beta-lactamase PDC-586
        blaPDC-587       NG_242598.1 WP_338424134.1     class C beta-lactamase PDC-587
        blaPDC-588       NG_242599.1 WP_338424135.1     class C beta-lactamase PDC-588
        blaPDC-589       NG_242600.1 WP_338424136.1     class C beta-lactamase PDC-589
        blaPDC-590       NG_242601.1 WP_338424137.1     class C beta-lactamase PDC-590
        blaPDC-591       NG_242602.1 WP_338424138.1     class C beta-lactamase PDC-591
        blaPDC-592       NG_242603.1 WP_338424139.1     class C beta-lactamase PDC-592
        blaPNC-1         NG_242604.1 WP_322881141.1     class C beta-lactamase PNC-1
        blaSED-2         NG_242605.1 WP_338424140.1     class A beta-lactamase SED-2
        blaSHV-244       NG_242606.1 WP_064738859.1     class A beta-lactamase SHV-244
        blaVEB-34        NG_242607.1 WP_338424141.1     extended-spectrum class A beta-lactamase VEB-34
        blaVIM-87        NG_242608.1 WP_338424142.1     subclass B1 metallo-beta-lactamase VIM-87
    plus AMR AMR
        cxpE             CP008706.1 AKA30736.1          chloramphenicol efflux transporter CxpE
        norM             AB010463.1 BAA31456.1          multidrug efflux MATE transporter NorM
        mcr-11.1         CP042930.1 QEY54480.1          phosphoethanolamine--lipid A transferase MCR-11.1
    plus STRESS ACID
        gadD1            AL591975.1 CAC98526.1          glutamate decarboxylase GadD1
    plus STRESS METAL
        merB3            LC152290.1 BAA89005.2          organomercurial lyase MerB3
        merB2            LC152290.1 BAA89007.1          organomercurial lyase MerB2
        merB3            AB066362.1 BAB62428.1          organomercurial lyase MerB3
    plus VIRULENCE VIRULENCE
        stxA2            M59432.1 AAA19623.1            Shiga toxin Stx2 subunit A
        stxA1            M19473.1 AAA98151.1            Shiga toxin Stx1a subunit A
        stxA1            M19437.1 AAA98347.1            Shiga toxin Stx1a subunit A
        inlC             U77368.1 AAB67969.1            class 1 internalin InlC2
        inlD             U77368.1 AAB67970.1            class 1 internalin InlD
        spvD             AF329248.1 AAG59626.1          SPI-2 type III secretion system effector cysteine hydrolase SpvD
        sseK2            AE006468.2 AAL21040.1          type III secretion system effector arginine glycosyltransferase SseK2
        avrA             AE006468.2 AAL21745.1          type III secretion system YopJ family effector AvrA
        stxB2            AF479828.1 AAM88303.1          Shiga toxin Stx2c subunit B
        stxB2            AY286000.1 AAP37404.1          Shiga toxin Stx2g subunit B
        stxA2            AY443043.1 AAS07578.1          Shiga toxin Stx2c subunit A
        stxB2            EF441616.1 ABR10025.1          Shiga toxin Stx2b subunit B
        aut              CP001602.2 ADB67911.1          peptidoglycan hydrolase Auto
        inlG             CP002002.1 AEO05269.1          class 1 internalin InlG
        inlH             CP002003.1 AEO24563.1          class 1 internalin InlH
        vip              CP002003.1 AEO24620.1          cell invasion LPXTG protein Vip
        inlI             CP002003.1 AEO24631.1          class 1 internalin InlI
        inlF             CP002003.1 AEO24707.1          class 1 internalin InlF
        inlB             CP002003.1 AEO24731.1          GW domain-containing class 2 internalin InlB
        lntA             CP002003.1 AEO24735.1          nuclear targeted protein LntA
        inl-lmo0514      CP002003.1 AEO24812.1          lmo0514 family class 1 internalin Inl-lmo0514
        inl-lmo0610      CP002003.1 AEO24908.1          lmo0610 family class 1 internalin Inl-lmo0610
        inlK             CP002003.1 AEO25637.1          class 1 internalin InlK
        inlP             CP002003.1 AEO26812.1          class 3 internalin InlP
        inlC             CP007160.1 AHJ03495.1          class 3 internalin InlC
        ami              CP007194.1 ASH48222.1          autolysin Ami
        cpa              KY978630.1 ASR82161.1          omptin family outer membrane protease Cpa
        stxA2            AB048228.1 BAB83004.1          Shiga toxin Stx2b subunit A
        stxB1            AB071622.1 BAC10990.1          Shiga toxin Stx1c subunit B
        inlE             AJ007319.1 CAA07458.1          class 1 internalin InlE
        gtgA             FQ312003.1 CBW17061.1          type III secretion system effector protease GtgA
        sseK3            FQ312003.1 CBW18025.1          type III secretion system effector arginine glycosyltransferase SseK3
        inlL             HG421741.1 CDG45949.1          class 1 internalin InlL
        stxA2            RUOX02000009.1 EED0303792.1    Shiga toxin Stx2j subunit A
        stxA2            AARDFE010000017.1 EES5259043.1 Shiga toxin Stx2j subunit A
        stxA2            AARGRV010000082.1 EET7735230.1 Shiga toxin Stx2m subunit A
        stxB2            AARGRV010000082.1 EET7735231.1 Shiga toxin Stx2m subunit B
        stxA2            AASBEA010000053.1 EFA5701809.1 Shiga toxin Stx2j subunit A
        stxA2            AASOQD010000025.1 EFE9806287.1 Shiga toxin Stx2j subunit A
        stxA2            AATFJO020000039.1 EMA1832120.1 Shiga toxin Stx2j subunit A
        aalE             AQEW01000031.1 EMX33340.1      CS23 fimbrial major subunit AalE
        stxB2            BGDW01000072.1 GDQ67223.1      Shiga toxin Stx2c subunit B
        stxA2            BGDW01000072.1 GDQ67229.1      Shiga toxin Stx2c subunit A
        stxA2            BGEN01000020.1 GDR53740.1      Shiga toxin Stx2 subunit A
        stxA2            BGGH01000007.1 GDR79703.1      Shiga toxin Stx2c subunit A
        stxA2            WSHT01000077.1 KAE9951533.1    Shiga toxin Stx2c subunit A
        stxA2            LGZW01000080.1 KNG05165.1      Shiga toxin Stx2c subunit A
        stxA1            JACISP010000011.1 MBZ9250874.1 Shiga toxin Stx1a subunit A
        stxA1            JAOQKQ010000001.1 MCW3225953.1 Shiga toxin Stx1a subunit A
        stxB2            JAOQKQ010000001.1 MCW3229578.1 Shiga toxin Stx2d subunit B
        cstB             RNIX01000076.1 MHF63232.1      CS3 fimbrial usher protein CstB
        stxA2            MRVY01000159.1 PAU09262.1      Shiga toxin Stx2 subunit A
        sspH2            CP052807.1 QJV46475.1          SPI-2 type III secretion system effector E3 ubiquitin transferase SspH2
        stxA2            MZ229604.1 QZL10982.1          Shiga toxin Stx2o subunit A
        stxA2            MZ229605.1 QZL10984.1          Shiga toxin Stx2a subunit A
        stxA2            MZ229607.1 QZL10988.1          Shiga toxin Stx2b subunit A
        stxA2            RRSO01000070.1 TJA36680.1      Shiga toxin Stx2 subunit A
        stxA1            CP061239.1 UIU88878.1          Shiga toxin Stx1a subunit A
        stxA2            CP113091.1 WAK52085.1          Shiga toxin Stx2o subunit A
        stxA2            CP113092.1 WAK53220.1          Shiga toxin Stx2n subunit A
        lpfB             CP149214.1 WXV87835.1          long polar fimbrial chaperone LpfB
        invA             CP149285.1 WXW86397.1          type III secretion system export apparatus protein InvA
Added point mutations
    core AMR POINT
        baeS_Q163E       TEMOCILLIN Escherichia
        baeS_R153P       TEMOCILLIN Escherichia
        baeS_T175P       TEMOCILLIN Escherichia
        dltC_S63C        DAPTOMYCIN Enterococcus_faecium
        folP_F28I        SULFONAMIDE Salmonella
        folP_F28L        SULFONAMIDE Salmonella
        folP_R171P       SULFONAMIDE Salmonella
        ftsI_R335RVPYR   CEPHALOSPORIN Escherichia
        liaR_S19F        DAPTOMYCIN Enterococcus_faecium
        rplD_G74D        ERYTHROMYCIN/TYLOSIN Campylobacter
        rplD_KG68del     AZITHROMYCIN/CHLORAMPHENICOL/CLARITHROMYCIN/ERYTHROMYCIN/LINEZOLID Streptococcus_pneumoniae
        rplD_WR65del     AZITHROMYCIN/CHLORAMPHENICOL/CLARITHROMYCIN/ERYTHROMYCIN/LINEZOLID Streptococcus_pneumoniae
        rplV_A103C       ERYTHROMYCIN Campylobacter
        rplV_A103V       MACROLIDE Campylobacter
        rplV_A103V       MACROLIDE Campylobacter
        rplV_A84D        MACROLIDE Campylobacter
        rplV_A84D        MACROLIDE Campylobacter
        rplV_A88E        MACROLIDE Campylobacter
        rplV_A88E        MACROLIDE Campylobacter
        rplV_G86E        MACROLIDE Campylobacter
        rplV_G86E        MACROLIDE Campylobacter
        rplV_G86V        MACROLIDE Campylobacter
        rplV_G86V        MACROLIDE Campylobacter
        rplV_H97HTSH     ERYTHROMYCIN/TYLOSIN Campylobacter
        rplV_H97HTSH     ERYTHROMYCIN/TYLOSIN Campylobacter
        rplV_R85RARAR    ERYTHROMYCIN/TYLOSIN Campylobacter
        rplV_R85RARAR    ERYTHROMYCIN/TYLOSIN Campylobacter
        rpoB_G482D       DAPTOMYCIN/RIFAXIMIN Enterococcus_faecium
        rpoB_H486Y       DAPTOMYCIN/RIFAXIMIN Enterococcus_faecium
        rpoC_T641K       DAPTOMYCIN Enterococcus_faecium
Removed proteins
    core AMR AMR
        blaOXA-18        NG_049480.1 WP_063861237.1     extended-spectrum class D beta-lactamase OXA-18
    plus VIRULENCE VIRULENCE
        stxA1a           M16625.1 AAA98099.1            Shiga toxin Stx1a subunit A
        stxA2a           AY443054.1 AAS07600.1          Shiga toxin Stx2a subunit A
        stxA2c           EU086525.1 ABU55302.1          Shiga toxin Stx2c subunit A
        aalE             JQ434477.1 AFD29291.1          CS23 fimbrial major subunit AalE
        stxB2b           AB012101.1 BAA77750.1          Shiga toxin Stx2b subunit B
        stxB2c           AB071845.1 BAB68370.1          Shiga toxin Stx2c subunit B
        stxA2b           AB048224.1 BAB82996.1          Shiga toxin Stx2b subunit A
        stxB2g           AB048227.1 BAB83003.1          Shiga toxin Stx2g subunit B
        stxA2c           X07865.1 CAA30714.1            Shiga toxin Stx2c subunit A
        cstB             X16944.1 CAA34816.1            CS3 fimbrial usher protein CstB
        stxA2a           Z37725.1 CAA85780.1            Shiga toxin Stx2a subunit A
        stxA2o           AARLAS010000016.1 EEV0948227.1 Shiga toxin Stx2o subunit A
        stxA2n           CP113094.1 WAK61649.1          Shiga toxin Stx2n subunit A
        stxA2m           OQ054797.1 WGO76391.1          Shiga toxin Stx2m subunit A
        stxB2m           OQ054797.1 WGO76392.1          Shiga toxin Stx2m subunit B
Removed point mutations
    core AMR POINT
        50S_L22_A103C    ERYTHROMYCIN Campylobacter
        50S_L22_A103V    MACROLIDE Campylobacter
        50S_L22_A103V    MACROLIDE Campylobacter
        50S_L22_A84D     MACROLIDE Campylobacter
        50S_L22_A84D     MACROLIDE Campylobacter
        50S_L22_A88E     MACROLIDE Campylobacter
        50S_L22_A88E     MACROLIDE Campylobacter
        50S_L22_G86E     MACROLIDE Campylobacter
        50S_L22_G86E     MACROLIDE Campylobacter
        50S_L22_G86V     MACROLIDE Campylobacter
        50S_L22_G86V     MACROLIDE Campylobacter
Changed reference gene catalog records
    stxA2 AAA16360.1
        gene_family:     stxA2b -> stxA2
        subclass:        STX2B -> stxA2b
    stxB2 AAA16361.1
        gene_family:     stxB2b -> stxB2
        subclass:        STX2B -> stxB2b
    stxA2 AAA16362.1
        gene_family:     stxA2c -> stxA2
        subclass:        STX2C -> stxA2c
    stxA2 AAA19189.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxB2 AAA19190.1
        gene_family:     stxB2e -> stxB2
        subclass:        STX2E -> stxB2e
    stxA2 AAA24632.1
        gene_family:     stxA2f -> stxA2
        subclass:        STX2F -> stxA2f
    stxB2 AAA24633.1
        gene_family:     stxB2f -> stxB2
        subclass:        STX2F -> stxB2f
    stxA1 AAA71893.1
        gene_family:     stxA1a -> stxA1
        subclass:        STX1A -> stxA1a
    stxB1 AAA71894.1
        gene_family:     stxB1a -> stxB1
        subclass:        STX1A -> stxB1a
    merB AAC38230.1
        class:           MERCURY -> <empty>
        hierarchy_node:  merB -> merB_gen
        subclass:        ORGANOMERCURY -> <empty>
    stxA2 AAC45964.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxB2 AAC45965.1
        gene_family:     stxB2e -> stxB2
        subclass:        STX2E -> stxB2e
    stxA2 AAD12174.1
        gene_family:     stxA2b -> stxA2
        subclass:        STX2B -> stxA2b
    stxA2 AAG01033.1
        gene_family:     stxA2c -> stxA2
        subclass:        STX2C -> stxA2c
    mexE AAG05881.1
        product_name:    MexE family multidrug efflux RND transporter periplasmic adaptor subunit -> multidrug efflux RND transporter periplasmic adaptor subunit MexE
    norM AAG27731.1
        hierarchy_node:  norM -> norM-Burk
        product_name:    sodium-coupled multidrug efflux MATE transporter NorM -> multidrug efflux MATE transporter NorM
    stxA2 AAK66972.1
        gene_family:     stxA2d -> stxA2
        subclass:        STX2D -> stxA2d
    stxA2 AAM22256.1
        gene_family:     stxA2d -> stxA2
        hierarchy_node:  stxA2d -> stxA2_acd
        product_name:    Shiga toxin Stx2d subunit A -> Shiga toxin Stx2 subunit A
        subclass:        STX2D -> stxA2
    stxB2 AAM22257.1
        gene_family:     stxB2d -> stxB2
        subclass:        STX2D -> stxB2d
    stxA2 AAM70045.1
        gene_family:     stxA2a -> stxA2
        subclass:        STX2A -> stxA2a
    stxA2 AAM88302.1
        gene_family:     stxA2d -> stxA2
        subclass:        STX2D -> stxA2d
    stxB2 AAM90978.1
        gene_family:     stxB2a -> stxB2
        subclass:        STX2A -> stxB2a
    stxA2 AAN77057.1
        gene_family:     stxA2d -> stxA2
        subclass:        STX2D -> stxA2d
    stxA2 AAN77061.1
        gene_family:     stxA2d -> stxA2
        subclass:        STX2D -> stxA2d
    stxA2 AAN77063.1
        gene_family:     stxA2d -> stxA2
        subclass:        STX2D -> stxA2d
    stxA1 AAO19475.1
        gene_family:     stxA1d -> stxA1
        subclass:        STX1D -> stxA1d
    stxB1 AAO19476.1
        gene_family:     stxB1d -> stxB1
        subclass:        STX1D -> stxB1d
    stxA2 AAP37403.1
        gene_family:     stxA2g -> stxA2
        subclass:        STX2G -> stxA2g
    stxA2 AAQ17546.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxA2 AAS07580.1
        gene_family:     stxA2c -> stxA2
        subclass:        STX2C -> stxA2c
    stxB2 AAS07581.1
        gene_family:     stxB2c -> stxB2
        subclass:        STX2C -> stxB2c
    stxA2 AAS07582.1
        gene_family:     stxA2c -> stxA2
        hierarchy_node:  stxA2c -> stxA2_acd
        product_name:    Shiga toxin Stx2c subunit A -> Shiga toxin Stx2 subunit A
        subclass:        STX2C -> stxA2
    stxA2 AAS07586.1
        gene_family:     stxA2d -> stxA2
        subclass:        STX2D -> stxA2d
    stxA2 AAS07588.1
        gene_family:     stxA2d -> stxA2
        subclass:        STX2D -> stxA2d
    stxB2 AAS07589.1
        gene_family:     stxB2d -> stxB2
        subclass:        STX2D -> stxB2d
    stxA2 AAS07590.1
        gene_family:     stxA2c -> stxA2
        subclass:        STX2C -> stxA2c
    stxA2 AAS07596.1
        gene_family:     stxA2c -> stxA2
        hierarchy_node:  stxA2c -> stxA2_acd
        product_name:    Shiga toxin Stx2c subunit A -> Shiga toxin Stx2 subunit A
        subclass:        STX2C -> stxA2
    stxA2 AAS07606.1
        gene_family:     stxA2a -> stxA2
        subclass:        STX2A -> stxA2a
    cvaB AAS50165.1
        gene_family:     mchF -> cvaB
        hierarchy_node:  mchF -> cvaB
        product_name:    microcin H47 export transporter peptidase/ATP-binding subunit MchF -> colicin V export peptidase/ABC transporter CvaB
    stxA2 AAT65972.1
        gene_family:     stxA2c -> stxA2
        subclass:        STX2C -> stxA2c
    stxA2 AAT66000.1
        gene_family:     stxA2c -> stxA2
        subclass:        STX2C -> stxA2c
    stxA2 AAT66010.1
        gene_family:     stxA2a -> stxA2
        subclass:        STX2A -> stxA2a
    stxB2 AAT66011.1
        gene_family:     stxB2a -> stxB2
        hierarchy_node:  stxB2a -> stxB2
        product_name:    Shiga toxin Stx2a subunit B -> Shiga toxin Stx2 subunit B
        subclass:        STX2A -> stxB2
    stxA2 AAT66012.1
        gene_family:     stxA2c -> stxA2
        subclass:        STX2C -> stxA2c
    stxA2 AAU88208.1
        gene_family:     stxA2c -> stxA2
        subclass:        STX2C -> stxA2c
    stxA2 AAY63864.1
        gene_family:     stxA2d -> stxA2
        subclass:        STX2D -> stxA2d
    stxA2 ABB36584.1
        gene_family:     stxA2c -> stxA2
        subclass:        STX2C -> stxA2c
    stxA2 ABB36586.1
        gene_family:     stxA2d -> stxA2
        hierarchy_node:  stxA2d -> stxA2_acd
        product_name:    Shiga toxin Stx2d subunit A -> Shiga toxin Stx2 subunit A
        subclass:        STX2D -> stxA2
    stxA2 ABC67318.2
        gene_family:     stxA2a -> stxA2
        subclass:        STX2A -> stxA2a
    stxB2 ABR09925.1
        gene_family:     stxB2a -> stxB2
        subclass:        STX2A -> stxB2a
    stxA2 ABR09934.1
        gene_family:     stxA2c -> stxA2
        hierarchy_node:  stxA2c -> stxA2_acd
        product_name:    Shiga toxin Stx2c subunit A -> Shiga toxin Stx2 subunit A
        subclass:        STX2C -> stxA2
    stxB2 ABR09935.1
        gene_family:     stxB2c -> stxB2
        hierarchy_node:  stxB2c -> stxB2
        product_name:    Shiga toxin Stx2c subunit B -> Shiga toxin Stx2 subunit B
        subclass:        STX2C -> stxB2
    stxA2 ABR09936.1
        gene_family:     stxA2d -> stxA2
        subclass:        STX2D -> stxA2d
    stxB2 ABR09937.1
        gene_family:     stxB2d -> stxB2
        hierarchy_node:  stxB2d -> stxB2
        product_name:    Shiga toxin Stx2d subunit B -> Shiga toxin Stx2 subunit B
        subclass:        STX2D -> stxB2
    stxB2 ABR09945.1
        gene_family:     stxB2a -> stxB2
        subclass:        STX2A -> stxB2a
    stxB2 ABR09961.1
        gene_family:     stxB2a -> stxB2
        subclass:        STX2A -> stxB2a
    stxB2 ABR09963.1
        gene_family:     stxB2a -> stxB2
        subclass:        STX2A -> stxB2a
    stxA2 ABR10024.1
        gene_family:     stxA2b -> stxA2
        subclass:        STX2B -> stxA2b
    stxA2 ACU32684.1
        gene_family:     stxA2a -> stxA2
        subclass:        STX2A -> stxA2a
    stxA2 AGB13719.2
        gene_family:     stxA2k -> stxA2
        subclass:        STX2K -> stxA2k
    cvaB AGC14252.1
        gene_family:     mchF -> cvaB
        hierarchy_node:  mchF -> cvaB
        product_name:    microcin H47 export transporter peptidase/ATP-binding subunit MchF -> colicin V export peptidase/ABC transporter CvaB
    stxB1 AHJ80154.1
        gene_family:     stxB1e -> stxB1
        subclass:        STX1E -> stxB1e
    stxA1 AHJ80155.1
        gene_family:     stxA1e -> stxA1
        subclass:        STX1E -> stxA1e
    stxB2 AUM09787.1
        gene_family:     stxB2h -> stxB2
        subclass:        STX2H -> stxB2h
    stxA2 AUM09788.1
        gene_family:     stxA2h -> stxA2
        subclass:        STX2H -> stxA2h
    stxA2 BAA77749.1
        gene_family:     stxA2b -> stxA2
        subclass:        STX2B -> stxA2b
    stxA2 BAA77751.1
        gene_family:     stxA2b -> stxA2
        subclass:        STX2B -> stxA2b
    stxA2 BAB68369.1
        gene_family:     stxA2c -> stxA2
        subclass:        STX2C -> stxA2c
    stxA2 BAB82994.1
        gene_family:     stxA2b -> stxA2
        subclass:        STX2B -> stxA2b
    stxA2 BAB82998.1
        gene_family:     stxA2b -> stxA2
        subclass:        STX2B -> stxA2b
    stxA2 BAB83000.1
        gene_family:     stxA2b -> stxA2
        subclass:        STX2B -> stxA2b
    stxA2 BAB83002.1
        gene_family:     stxA2g -> stxA2
        subclass:        STX2G -> stxA2g
    stxB2 BAB83005.1
        gene_family:     stxB2b -> stxB2
        subclass:        STX2B -> stxB2b
    stxB2 BAB83007.1
        gene_family:     stxB2b -> stxB2
        subclass:        STX2B -> stxB2b
    stxA2 BAB83020.1
        gene_family:     stxA2g -> stxA2
        subclass:        STX2G -> stxA2g
    stxA1 BAB83022.1
        gene_family:     stxA1c -> stxA1
        subclass:        STX1C -> stxA1c
    stxB1 BAB83023.1
        gene_family:     stxB1c -> stxB1
        subclass:        STX1C -> stxB1c
    stxA2 BAB83024.1
        gene_family:     stxA2b -> stxA2
        subclass:        STX2B -> stxA2b
    stxA1 BAC10987.1
        gene_family:     stxA1a -> stxA1
        subclass:        STX1A -> stxA1a
    stxB1 BAC10988.1
        gene_family:     stxB1a -> stxB1
        subclass:        STX1A -> stxB1a
    stxB1 BAC10992.1
        gene_family:     stxB1c -> stxB1
        subclass:        STX1C -> stxB1c
    stxA1 BAC78639.1
        gene_family:     stxA1a -> stxA1
        subclass:        STX1A -> stxA1a
    stxB1 BAC78640.1
        gene_family:     stxB1a -> stxB1
        subclass:        STX1A -> stxB1a
    stxA2 BAH86759.1
        gene_family:     stxA2f -> stxA2
        subclass:        STX2F -> stxA2f
    stxB2 BAH86760.1
        gene_family:     stxB2f -> stxB2
        subclass:        STX2F -> stxB2f
    stxB2 CAA30715.1
        gene_family:     stxB2a -> stxB2
        subclass:        STX2A -> stxB2a
    cvaB CAA40744.1
        gene_family:     mchF -> cvaB
        hierarchy_node:  mchF -> cvaB
        product_name:    microcin H47 export transporter peptidase/ATP-binding subunit MchF -> colicin V export peptidase/ABC transporter CvaB
    stxA2 CAA43585.1
        gene_family:     stxA2d -> stxA2
        subclass:        STX2D -> stxA2d
    stxA2 CAA46767.1
        gene_family:     stxA2b -> stxA2
        subclass:        STX2B -> stxA2b
    stxB2 CAA46768.1
        gene_family:     stxB2b -> stxB2
        subclass:        STX2B -> stxB2b
    stxA2 CAA57171.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxA2 CAA57173.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxA2 CAA57175.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxA2 CAA57177.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxA1 CAA85366.1
        gene_family:     stxA1a -> stxA1
        subclass:        STX1A -> stxA1a
    stxA1 CAA85368.1
        gene_family:     stxA1a -> stxA1
        subclass:        STX1A -> stxA1a
    stxA1 CAA85370.1
        gene_family:     stxA1c -> stxA1
        subclass:        STX1C -> stxA1c
    stxB1 CAA85371.1
        gene_family:     stxB1c -> stxB1
        subclass:        STX1C -> stxB1c
    stxA2 CAA90630.1
        gene_family:     stxA2a -> stxA2
        subclass:        STX2A -> stxA2a
    stxA2 CAB64953.1
        gene_family:     stxA2f -> stxA2
        subclass:        STX2F -> stxA2f
    stxA2 CAB77169.2
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxB2 CAB94149.1
        gene_family:     stxB2a -> stxB2
        subclass:        STX2A -> stxB2a
    stxA2 CAC48396.1
        gene_family:     stxA2b -> stxA2
        subclass:        STX2B -> stxA2b
    stxA2 CAC48398.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxA2 CAI91198.1
        gene_family:     stxA2g -> stxA2
        subclass:        STX2G -> stxA2g
    stxA1 CAJ76690.1
        gene_family:     stxA1a -> stxA1
        subclass:        STX1A -> stxA1a
    stxA1 CAJ76692.1
        gene_family:     stxA1a -> stxA1
        subclass:        STX1A -> stxA1a
    mexE CAK15125.1
        product_name:    MexE family multidrug efflux RND transporter periplasmic adaptor subunit -> multidrug efflux RND transporter periplasmic adaptor subunit MexE
    stxA2 CAP17609.1
        gene_family:     stxA2l -> stxA2
        subclass:        STX2L -> stxA2l
    stxB2 CAP17610.1
        gene_family:     stxB2l -> stxB2
        hierarchy_node:  stxB2l -> stxB2
        product_name:    Shiga toxin Stx2l subunit B -> Shiga toxin Stx2 subunit B
        subclass:        STX2L -> stxB2
    stxA2 CAQ68302.1
        gene_family:     stxA2c -> stxA2
        hierarchy_node:  stxA2c -> stxA2_acd
        product_name:    Shiga toxin Stx2c subunit A -> Shiga toxin Stx2 subunit A
        subclass:        STX2C -> stxA2
    stxA2 CAX45702.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxA2 CAX45706.1
        gene_family:     stxA2d -> stxA2
        subclass:        STX2D -> stxA2d
    stxA2 CAX45714.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxA2 CAX45718.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxB2 CAX45737.1
        gene_family:     stxB2d -> stxB2
        subclass:        STX2D -> stxB2d
    stxB2 CAX45739.1
        gene_family:     stxB2a -> stxB2
        subclass:        STX2A -> stxB2a
    stxA2 CAX45746.1
        gene_family:     stxA2c -> stxA2
        subclass:        STX2C -> stxA2c
    stxA2 CAX51714.1
        gene_family:     stxA2e -> stxA2
        subclass:        STX2E -> stxA2e
    stxA2 CAX53241.1
        gene_family:     stxA2i -> stxA2
        subclass:        STX2I -> stxA2i
    stxB2 CAX53242.1
        gene_family:     stxB2i -> stxB2
        subclass:        STX2I -> stxB2i
    stxB2 EED0303793.1
        gene_family:     stxB2j -> stxB2
        subclass:        STX2J -> stxB2j
    stxB2 EEV0948228.1
        gene_family:     stxB2o -> stxB2
        subclass:        STX2O -> stxB2o
    norM EFF39147.1
        hierarchy_node:  norM -> norM-NG
    stxB2 QHR28666.1
        gene_family:     stxB2k -> stxB2
        hierarchy_node:  stxB2k -> stxB2
        product_name:    Shiga toxin Stx2k subunit B -> Shiga toxin Stx2 subunit B
        subclass:        STX2K -> stxB2
    stxA2 QHR28667.1
        gene_family:     stxA2k -> stxA2
        subclass:        STX2K -> stxA2k
    stxA2 QZN05543.1
        gene_family:     stxA2j -> stxA2
        subclass:        STX2J -> stxA2j
    stxB2 WAK53219.1
        gene_family:     stxB2n -> stxB2
        subclass:        STX2N -> stxB2n
    fosB WP_000920239.1
        hierarchy_node:  fosB-Saur -> fosB_gen
    aac(3)-C1264 WP_034000523.1
        genbank_nucleotide_accession: ABKGBU020000026.1 -> ABKGBU030000026.1
        genbank_protein_accession: EKW6221576.1 -> EML4797591.1
    blaCMH-9 WP_058650678.1
        genbank_nucleotide_accession: ABFHGH020000056.1 -> ABFHGH030000056.1
        genbank_protein_accession: EKU2771784.1 -> EMN0879540.1
    blaCTX-M-178 WP_104009847.1
        product_name:    extended-spectrum class A beta-lactamase CTX-M-178 -> inhibitor-resistant class A beta-lactamase CTX-M-178
        pubmed_reference: <empty> -> 38366372
        subclass:        CEPHALOSPORIN -> BETA-LACTAM
    blaCTX-M-255 WP_254205601.1
        product_name:    extended-spectrum class A beta-lactamase CTX-M-255 -> inhibitor-resistant class A beta-lactamase CTX-M-255
        pubmed_reference: <empty> -> 38366372
        subclass:        CEPHALOSPORIN -> BETA-LACTAM
    blaNDM-30 WP_197749405.1
        product_name:    subclass B1 metallo-beta-lactamase NDM-30 -> taniborbactam-resistant subclass B1 metallo-beta-lactamase NDM-30
        pubmed_reference: <empty> -> 38047644
        subclass:        CARBAPENEM -> CARBAPENEM/TANIBORBACTAM
    blaNDM-50 WP_274293087.1
        genbank_nucleotide_accession: ABJWWM020000052.1 -> ABJWWM030000052.1
        genbank_protein_accession: EKV8557274.1 -> EMM3083081.1
    blaOXA-1149 WP_150664304.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1152 WP_150662373.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-258 WP_063569909.1
        product_name:    class D beta-lactamase OXA-258 -> carbapenem-hydrolyzing class D beta-lactamase OXA-258
    blaOXA-925 WP_100507493.1
        product_name:    class D beta-lactamase OXA-925 -> carbapenem-hydrolyzing class D beta-lactamase OXA-925
    blaOXA-955 WP_213994600.1
        genbank_nucleotide_accession: AAYMEH020000029.1 -> AAYMEH030000029.1
        genbank_protein_accession: EKY1045811.1 -> EMM9379972.1
    cls_H215R WP_002289473.1
        pubmed_reference: <empty> -> 26200029
    cls_R218Q WP_002289473.1
        pubmed_reference: <empty> -> 26200029
    colS_A106V WP_003094037.1
        product_name:    HAMP domain-containing sensor histidine kinase colS -> HAMP domain-containing sensor histidine kinase ColS
    czcS_V194L WP_003113318.1
        product_name:    sensor histidine kinase czcS -> sensor histidine kinase CzcS
    dfrB_A135T WP_000175752.1
        product_name:    dihydrofolate reductase -> dihydrofolate reductase DfrB
    dfrB_F99I WP_000175752.1
        product_name:    dihydrofolate reductase -> dihydrofolate reductase DfrB
    dfrB_F99S WP_000175752.1
        product_name:    dihydrofolate reductase -> dihydrofolate reductase DfrB
    dfrB_F99Y WP_000175752.1
        product_name:    dihydrofolate reductase -> dihydrofolate reductase DfrB
    dfrB_H150R WP_000175752.1
        product_name:    dihydrofolate reductase -> dihydrofolate reductase DfrB
    dfrB_H31N WP_000175752.1
        product_name:    dihydrofolate reductase -> dihydrofolate reductase DfrB
    dfrB_L21V WP_000175752.1
        product_name:    dihydrofolate reductase -> dihydrofolate reductase DfrB
    dfrB_L25I WP_000175752.1
        product_name:    dihydrofolate reductase -> dihydrofolate reductase DfrB
    dfrB_L41F WP_000175752.1
        product_name:    dihydrofolate reductase -> dihydrofolate reductase DfrB
    dfrB_N60I WP_000175752.1
        product_name:    dihydrofolate reductase -> dihydrofolate reductase DfrB
    folP_A184V WP_000167936.1
        product_name:    dihydropteroate synthase -> dihydropteroate synthase FolP
    folP_E208K WP_000167936.1
        product_name:    dihydropteroate synthase -> dihydropteroate synthase FolP
    folP_E258EKE WP_000167936.1
        product_name:    dihydropteroate synthase -> dihydropteroate synthase FolP
    folP_F17L WP_000167936.1
        product_name:    dihydropteroate synthase -> dihydropteroate synthase FolP
    folP_S18L WP_000167936.1
        product_name:    dihydropteroate synthase -> dihydropteroate synthase FolP
    folP_T51M WP_000167936.1
        product_name:    dihydropteroate synthase -> dihydropteroate synthase FolP
    fusA1_A555E WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_A595P WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_E100G WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_G545D WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_I61M WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_K504Q WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_L438Q WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_L464V WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_N592I WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_P554L WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_P618L WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_Q455R WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_Q678L WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_R371C WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_R680C WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_T456A WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_T671A WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_T671I WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA1_Y552C WP_003093741.1
        product_name:    elongation factor G -> elongation factor G FusA1
    fusA_A160V WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_A376V WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_A655E WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_A655P WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_A655V WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_C473S WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_D189G WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_D189V WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_D373N WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_D387I WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_D434N WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_D463G WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_E233Q WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_E444K WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_E444V WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_F652S WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_F88L WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_G451V WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_G452C WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_G452S WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_G452V WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_G556S WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_G617D WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_G664S WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_H438N WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_H457L WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_H457N WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_H457Q WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_H457Y WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_I449K WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_L430S WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_L456F WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_L456K WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_L461F WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_L461K WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_L461S WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_M453I WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_M651I WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_P114H WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_P404L WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_P404Q WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_P406L WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_P478S WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_Q115L WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_R464C WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_R464H WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_R464L WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_R464S WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_R659C WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_R659H WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_R659L WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_R659S WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_S416F WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_T385N WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_T436I WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_T656K WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_V407F WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_V607I WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_V90A WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_V90I WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    fusA_Y654N WP_000090315.1
        product_name:    elongation factor G -> elongation factor G FusA
    ileS_F563L WP_000384706.1
        product_name:    isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS
    ileS_G593V WP_000384706.1
        product_name:    isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS
    ileS_H67Q WP_000384706.1
        product_name:    isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS
    ileS_R816C WP_000384706.1
        product_name:    isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS
    ileS_V588F WP_000384706.1
        product_name:    isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS
    ileS_V631F WP_000384706.1
        product_name:    isoleucine--tRNA ligase -> isoleucine--tRNA ligase IleS
    mprF_G61V WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
    mprF_I420N WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
        pubmed_reference: <empty> -> 33796088
    mprF_L341S WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
    mprF_L826F WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
        pubmed_reference: <empty> -> 33796088
    mprF_M347R WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
    mprF_P314L WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
    mprF_S295L WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
        pubmed_reference: <empty> -> 33796088
    mprF_S337L WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
        pubmed_reference: <empty> -> 33796088
    mprF_T345A WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
    mprF_T345I WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
        pubmed_reference: <empty> -> 33796088
    mprF_T345K WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
    mprF_T472K WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
    mprF_V351E WP_111724484.1
        product_name:    bifunctional lysylphosphatidylglycerol flippase/synthetase -> bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
    pbp2_S569A WP_000138348.1
        product_name:    penicillin-binding protein -> penicillin-binding protein PBP2
    pbp4_E183A WP_123090655.1
        product_name:    D-alanyl-D-alanine carboxypeptidase -> D-alanyl-D-alanine carboxypeptidase PBP4
    pbp4_E218K WP_123090655.1
        product_name:    D-alanyl-D-alanine carboxypeptidase -> D-alanyl-D-alanine carboxypeptidase PBP4
    pbp4_F241R WP_123090655.1
        product_name:    D-alanyl-D-alanine carboxypeptidase -> D-alanyl-D-alanine carboxypeptidase PBP4
    pbp4_R200L WP_123090655.1
        product_name:    D-alanyl-D-alanine carboxypeptidase -> D-alanyl-D-alanine carboxypeptidase PBP4
    pbp4_T-266A NZ_RIXR01000001.1
        product_name:    D-alanyl-D-alanine carboxypeptidase -> D-alanyl-D-alanine carboxypeptidase PBP4
    pgsA_A64V WP_001025093.1
        product_name:    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -> CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA
    pgsA_K66R WP_001025093.1
        product_name:    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -> CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA
    pgsA_S177F WP_001025093.1
        product_name:    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -> CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA
    pgsA_V59N WP_001025093.1
        product_name:    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -> CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA
    vanR-Cd_T115A WP_003436401.1
        product_name:    vancomycin resistance response regulator transcription factor VanR-G-Cd -> vancomycin resistance response regulator transcription factor VanR-Cd

Hierarchy nodes added
    core AMR AMR
        ant(9)-Ic        ant(9)-Ic NF045909.1           aminoglycoside nucleotidyltransferase ANT(9)-Ic
        blaDYB           blaDYB NF045731.1              DYB family subclass B1 metallo-beta-lactamase
        blaMUN           blaMUN NF045651.1              MUN family extended-spectrum class A beta-lactamase
        blaOXA-1238_fam  blaOXA NF045807.1              OXA-1238 family class D beta-lactamase
        blaOXA-18_fam    blaOXA NF045839.1              OXA-18 family class D beta-lactamase
        blaOXA-258_fam   blaOXA NF045795.1              OXA-258 family carbapenem-hydrolyzing class D beta-lactamase
        blaPNC           blaPNC NF045671.1              PNC family class C beta-lactamase
        cmeB_RE          cmeB                           multidrug efflux RND transporter permease subunit CmeB, ciprofloxacin and florfenicol resistance type
        lnu(I)           lnu(I)                         lincosamide nucleotidyltransferase Lnu(I)
        tet(65)          tet(65) NF045684.1             tetracycline efflux MFS transporter Tet(65)
    non-reported STRESS ACID
        gad              gad                            glutamate-dependent acid resistance
        gadAB            gad                            glutamate decarboxylase
    non-reported VIRULENCE VIRULENCE
        VIRULENCE_Lmon
        VIRULENCE_Salmo
    plus AMR AMR
        cxpE             cxpE NF045801.1                chloramphenicol efflux transporter CxpE
        mcr-11           mcr-11                         MCR-11 family phosphoethanolamine--lipid A transferase
        norM-Burk        norM                           multidrug efflux MATE transporter NorM
        norM-NG          norM NF000263.1                sodium-coupled multidrug efflux MATE transporter NorM
        norM-Vib         norM                           multidrug efflux MATE transporter NorM
    plus STRESS ACID
        gadD1            gadD1                          glutamate decarboxylase GadD1
    plus STRESS METAL
        merB2            merB2                          organomercurial lyase MerB2
        merB3            merB3                          organomercurial lyase MerB3
    plus VIRULENCE VIRULENCE
        ami              ami                            autolysin Ami
        aut              aut                            peptidoglycan hydrolase Auto
        avrA             avrA                           type III secretion system YopJ family effector AvrA
        cpa_Csak         cpa                            omptin family outer membrane protease Cpa
        cvaB             cvaB                           colicin V export peptidase/ABC transporter CvaB
        gtgA             gtgA                           type III secretion system effector protease GtgA
        inlA             inlA NF033189.1                class 1 internalin InlA
        inlB             inlB                           GW domain-containing class 2 internalin InlB
        inlC             inlC                           class 3 internalin InlC
        inlC2            inlC                           class 1 internalin InlC2
        inlD             inlD                           class 1 internalin InlD
        inlE             inlE                           class 1 internalin InlE
        inlF             inlF                           class 1 internalin InlF
        inlG             inlG                           class 1 internalin InlG
        inlH             inlH                           class 1 internalin InlH
        inlI             inlI                           class 1 internalin InlI
        inlK             inlK NF033186.1                class 1 internalin InlK
        inlL             inlL                           class 1 internalin InlL
        inlP             inlP                           class 3 internalin InlP
        inl_lmo0514      inl-lmo0514                    lmo0514 family class 1 internalin Inl-lmo0514
        inl_lmo0610      inl-lmo0610                    lmo0610 family class 1 internalin Inl-lmo0610
        invA             invA                           type III secretion system export apparatus protein InvA
        lntA             lntA                           nuclear targeted protein LntA
        lpfB             lpfB                           long polar fimbrial chaperone LpfB
        spvD             spvD                           SPI-2 type III secretion system effector cysteine hydrolase SpvD
        sseK2            sseK2                          type III secretion system effector arginine glycosyltransferase SseK2
        sseK3            sseK3                          type III secretion system effector arginine glycosyltransferase SseK3
        sspH2            sspH2                          SPI-2 type III secretion system effector E3 ubiquitin transferase SspH2
        vip              vip NF033201.1                 cell invasion LPXTG protein Vip
Hierarchy nodes removed
    plus AMR AMR
        norM             norM NF000263.1                sodium-coupled multidrug efflux MATE transporter NorM
    plus VIRULENCE VIRULENCE
        stxB2k           stxB2k                         Shiga toxin Stx2k subunit B
        stxB2l           stxB2l                         Shiga toxin Stx2l subunit B
Changed Hierarchy Nodes
    abc-f            ABC-F type ribosomal protection protein
        class:           MACROLIDE -> RIBOSOMAL PROTECTION
        hmm_acc:         NF000355.3 -> <empty>
        scope:           core -> non-reported
        subclass:        MACROLIDE -> RIBOSOMAL PROTECTION
    ant(6)-Ig        aminoglycoside nucleotidyltransferase ANT(6)-Ig
        hmm_acc:         <empty> -> NF033221.1
    ant(9)           ANT(9) family aminoglycoside nucleotidyltransferase
        hmm_acc:         NF012212.0 -> NF012212.1
    aph(3')-H48      aminoglycoside O-phosphotransferase APH(3')-H48
        parent_node_id:  aph(3') -> aph(3')-II
    aph(3')-II       APH(3')-II family aminoglycoside O-phosphotransferase
        hmm_acc:         NF032898.1 -> NF032898.2
    aph(3')-VIII     aminoglycoside O-phosphotransferase APH(3')-VIII
        hmm_acc:         NF033066.0 -> <empty>
    aph(3')-VIIIa    aminoglycoside O-phosphotransferase APH(3')-VIIIa
        hmm_acc:         <empty> -> NF033066.0
    blaCAM           CAM family subclass B1 metallo-beta-lactamase
        hmm_acc:         NF033895.1 -> NF033895.2
    blaIMI           IMI family carbapenem-hydrolyzing class A beta-lactamase
        hmm_acc:         NF000400.2 -> NF000400.3
    blaOXA-427_fam   OXA-427 family carbapenem-hydrolyzing class D beta-lactamase
        hmm_acc:         NF038217.1 -> NF038217.2
    blaOXA-62_fam    OXA-62 family carbapenem-hydrolyzing class D beta-lactamase
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaSPR           SPR family subclass B3 metallo-beta-lactamase
        hmm_acc:         NF041137.1 -> NF041137.2
    cfr_gen          Cfr family 23S rRNA (adenine(2503)-C(8))-methyltransferase
        hmm_acc:         NF000424.3 -> NF000424.4
    lsa              Lsa family ABC-F type ribosomal protection protein
        hmm_acc:         NF000167.1 -> NF000167.2
    merB_gen         organomercurial lyase MerB
        scope:           non-reported -> plus
    mexE             multidrug efflux RND transporter periplasmic adaptor subunit MexE
        hmm_acc:         NF000249.1 -> NF045904.1
        name:            MexE family multidrug efflux RND transporter periplasmic adaptor subunit -> multidrug efflux RND transporter periplasmic adaptor subunit MexE
    msr              Msr family ABC-F type ribosomal protection protein
        hmm_acc:         NF000168.1 -> NF000168.2
    stxA1            Shiga toxin Stx1 subunit A
        hmm_acc:         NF033658.1 -> NF033658.2
        subclass:        STX1 -> stxA1
    stxA1a           Shiga toxin Stx1a subunit A
        subclass:        STX1A -> stxA1a
        symbol:          stxA1a -> stxA1
    stxA1c           Shiga toxin Stx1c subunit A
        subclass:        STX1C -> stxA1c
        symbol:          stxA1c -> stxA1
    stxA1d           Shiga toxin Stx1d subunit A
        subclass:        STX1D -> stxA1d
        symbol:          stxA1d -> stxA1
    stxA1e           Shiga toxin Stx1e subunit A
        subclass:        STX1E -> stxA1e
        symbol:          stxA1e -> stxA1
    stxA2            Shiga toxin Stx2 subunit A
        subclass:        STX2 -> stxA2
    stxA2_acd        Shiga toxin Stx2 subunit A
        name:            Shiga toxin Stx2 subunit A, a/c/d subtype -> Shiga toxin Stx2 subunit A
        subclass:        STX2 -> stxA2
    stxA2_eilk       Shiga toxin Stx2 subunit A, e/i/l/k subtype
        subclass:        STX2 -> stxA2
    stxA2a           Shiga toxin Stx2a subunit A
        subclass:        STX2A -> stxA2a
        symbol:          stxA2a -> stxA2
    stxA2b           Shiga toxin Stx2b subunit A
        subclass:        STX2B -> stxA2b
        symbol:          stxA2b -> stxA2
    stxA2c           Shiga toxin Stx2c subunit A
        subclass:        STX2C -> stxA2c
        symbol:          stxA2c -> stxA2
    stxA2d           Shiga toxin Stx2d subunit A
        subclass:        STX2D -> stxA2d
        symbol:          stxA2d -> stxA2
    stxA2e           Shiga toxin Stx2e subunit A
        subclass:        STX2E -> stxA2e
        symbol:          stxA2e -> stxA2
    stxA2f           Shiga toxin Stx2f subunit A
        subclass:        STX2F -> stxA2f
        symbol:          stxA2f -> stxA2
    stxA2g           Shiga toxin Stx2g subunit A
        subclass:        STX2G -> stxA2g
        symbol:          stxA2g -> stxA2
    stxA2h           Shiga toxin Stx2h subunit A
        subclass:        STX2H -> stxA2h
        symbol:          stxA2h -> stxA2
    stxA2i           Shiga toxin Stx2i subunit A
        subclass:        STX2I -> stxA2i
        symbol:          stxA2i -> stxA2
    stxA2j           Shiga toxin Stx2j subunit A
        subclass:        STX2J -> stxA2j
        symbol:          stxA2j -> stxA2
    stxA2k           Shiga toxin Stx2k subunit A
        subclass:        STX2K -> stxA2k
        symbol:          stxA2k -> stxA2
    stxA2l           Shiga toxin Stx2l subunit A
        subclass:        STX2L -> stxA2l
        symbol:          stxA2l -> stxA2
    stxA2m           Shiga toxin Stx2m subunit A
        subclass:        STX2M -> stxA2m
        symbol:          stxA2m -> stxA2
    stxA2n           Shiga toxin Stx2n subunit A
        subclass:        STX2N -> stxA2n
        symbol:          stxA2n -> stxA2
    stxA2o           Shiga toxin Stx2o subunit A
        subclass:        STX2O -> stxA2o
        symbol:          stxA2o -> stxA2
    stxB1            Shiga toxin Stx1 subunit B
        subclass:        STX1 -> stxB1
    stxB1a           Shiga toxin Stx1a subunit B
        subclass:        STX1A -> stxB1a
        symbol:          stxB1a -> stxB1
    stxB1c           Shiga toxin Stx1c subunit B
        subclass:        STX1C -> stxB1c
        symbol:          stxB1c -> stxB1
    stxB1d           Shiga toxin Stx1d subunit B
        subclass:        STX1D -> stxB1d
        symbol:          stxB1d -> stxB1
    stxB1e           Shiga toxin Stx1e subunit B
        subclass:        STX1E -> stxB1e
        symbol:          stxB1e -> stxB1
    stxB2            Shiga toxin Stx2 subunit B
        subclass:        STX2 -> stxB2
    stxB2a           Shiga toxin Stx2a subunit B
        subclass:        STX2A -> stxB2a
        symbol:          stxB2a -> stxB2
    stxB2b           Shiga toxin Stx2b subunit B
        subclass:        STX2B -> stxB2b
        symbol:          stxB2b -> stxB2
    stxB2c           Shiga toxin Stx2c subunit B
        subclass:        STX2C -> stxB2c
        symbol:          stxB2c -> stxB2
    stxB2d           Shiga toxin Stx2d subunit B
        subclass:        STX2D -> stxB2d
        symbol:          stxB2d -> stxB2
    stxB2e           Shiga toxin Stx2e subunit B
        subclass:        STX2E -> stxB2e
        symbol:          stxB2e -> stxB2
    stxB2f           Shiga toxin Stx2f subunit B
        subclass:        STX2F -> stxB2f
        symbol:          stxB2f -> stxB2
    stxB2g           Shiga toxin Stx2g subunit B
        subclass:        STX2G -> stxB2g
        symbol:          stxB2g -> stxB2
    stxB2h           Shiga toxin Stx2h subunit B
        subclass:        STX2H -> stxB2h
        symbol:          stxB2h -> stxB2
    stxB2i           Shiga toxin Stx2i subunit B
        subclass:        STX2I -> stxB2i
        symbol:          stxB2i -> stxB2
    stxB2j           Shiga toxin Stx2j subunit B
        subclass:        STX2J -> stxB2j
        symbol:          stxB2j -> stxB2
    stxB2m           Shiga toxin Stx2m subunit B
        subclass:        STX2M -> stxB2m
        symbol:          stxB2m -> stxB2
    stxB2n           Shiga toxin Stx2n subunit B
        subclass:        STX2N -> stxB2n
        symbol:          stxB2n -> stxB2
    stxB2o           Shiga toxin Stx2o subunit B
        subclass:        STX2O -> stxB2o
        symbol:          stxB2o -> stxB2
    vanW-I           glycopeptide resistance accessory protein VanW-I
        parent_node_id:  vanW -> AMR
    vga              Vga family ABC-F type ribosomal protection protein
        hmm_acc:         NF000170.1 -> NF000170.2
    vga(F)           ABC-F type ribosomal protection protein Vga(F)
        hmm_acc:         <empty> -> NF045691.1
----------------------------------------------------------------------
Changes included in 2024-01-31.1
----------------------------------------------------------------------

This release is in a new database format, so in order to use the latest version
of the AMRFinderPlus database (2020-05-04.1) you must upgrade to AMRFinderPlus
version 3.12.8. See
https://github.com/ncbi/amr/wiki/Upgrading#software-upgrades for information on
how to upgrade the AMRFinderPlus software.

Because this version is incompatible with AMRFinderPlus databases from previous
versions, amrfinder -u must be run once the software update is installed to get
the latest version of the database.

This update includes two basic changes:

- Reference proteins now have stop codons. Input proteins that are not
  terminated with a '*' character are assumed to have a '*' at the end.
- Extended proteins are no longer "EXACT" hits, so the protein names will be
  that of the parent node for alleles.

This means that Previously extended hits that were 100% identical to, but
longer than proteins in the database were called with the method "EXACTP" and
now they are called "BLASTP". Blast results will still indicate that 100% of
the database reference was covered at 100% identity, and you should still see
that the "Target length" is longer than the "Reference sequence length".

1. Extended hits to allele sequences that were previously called EXACTP already
had the element symbol was one node up the hierarchy (i.e. the gene symbol, not
the allele symbol) the "Sequence name" was that of the ALLELE reference, and
thus inconsistent with the element symbol assigned. This has been changed.
Again, this does not affect previous "Element symbol" calls.

2. In combined protein + nucleotide runs of AMRFinderPlus extended protein
sequences with exact matches in the database were ignored and the nucleotide
match was taken resulting in an EXACTX match with no protein accession
provided. Now the protein match with method BLASTP will be reported.

To reiterate, gene symbols should not change. Sequence names will only change
if the query is an extended version of a protein 100% identical and completely
covering an allele in the database.

Other than the database format change database release 2024-01-31.1 includes:

- cfaC (AAQ20107.1) was renamed to csuC
- Virulence genes for Burkholderia were reviewed and added
- A Campylobacter blaOXA-61 promoter mutation that confers carbapenem
  resistance was added, and blaOXA-143 promoter mutations for
  Acinetobacter_baumannii were renamed from to add the parent OXA allele
  number, for example blaOXA_G-42A was renamed to blaOXA-143_G-42A
- Multiple ETEC associated virulence factors were added
- Clostridium botulinum toxin genes were added
- New Clostridioides_difficile, Pseudomonas_aeruginosa, and Escherichia point
  mutations were added
- 212 Pubmed references were added

Summary:
   Total proteins: 8051
        Core proteins: 6866
        Plus proteins: 1182
   AMR proteins: 6912
   STRESS proteins: 253
   VIRULENCE proteins: 886
   PubMed references: 4381
   Point mutations: 1290
   Point mutation reference sequences: 227
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae,
       Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae,
       Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens,
       Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes, Vibrio_cholerae,
       Vibrio_parahaemolyticus, Vibrio_vulnificus
   HMMs: 730

Updates since release 2023-11-15.1:
   Proteins added: 116
       Core proteins added: 49
       Plus proteins added: 67
   AMR proteins added: 50
   VIRULENCE proteins added: 66
   Alleles added: 45
   PubMed references added: 212
   PubMed references removed: 2
   Point mutations added: 38
   Point mutations removed 2
   Reference Gene Catalog entries changed: 83
   Hierarchy nodes added: 81
   Hierarchy nodes changed: 1

Added proteins
    core AMR AMR
        aac(6')-E141     NG_242278.1 WP_026868862.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-E141
        blaPEN-H         NG_242279.1 WP_029226214.1     PEN-H family class A beta-lactamase
        erm(B)           NG_242280.1 WP_063844598.1     23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)
        vanY-M           NG_242281.1 WP_107309513.1     D-Ala-D-Ala carboxypeptidase VanY-M
        blaADC-344       NG_242282.1 WP_321981483.1     extended-spectrum class C beta-lactamase ADC-344
        blaADC-345       NG_242283.1 WP_321993619.1     extended-spectrum class C beta-lactamase ADC-345
        blaADC-346       NG_242284.1 WP_328703054.1     extended-spectrum class C beta-lactamase ADC-346
        blaCMY-190       NG_242285.1 WP_328703055.1     class C beta-lactamase CMY-190
        blaCTX-M-247     NG_242286.1 WP_328703056.1     extended-spectrum class A beta-lactamase CTX-M-247
        blaCTX-M-248     NG_242287.1 WP_121572426.1     extended-spectrum class A beta-lactamase CTX-M-248
        blaCTX-M-249     NG_242288.1 WP_328703057.1     extended-spectrum class A beta-lactamase CTX-M-249
        blaCTX-M-270     NG_242289.1 WP_322263690.1     extended-spectrum class A beta-lactamase CTX-M-270
        blaIMI-10        NG_242290.1 WP_319877346.1     carbapenem-hydrolyzing class A beta-lactamase IMI-10
        blaIMP-101       NG_242291.1 WP_328703058.1     subclass B1 metallo-beta-lactamase IMP-101
        blaIMP-50        NG_242292.1 WP_319861626.1     subclass B1 metallo-beta-lactamase IMP-50
        blaKPC-149       NG_242293.1 WP_328703059.1     carbapenem-hydrolyzing class A beta-lactamase KPC-149
        blaKPC-150       NG_242294.1 WP_328703060.1     inhibitor-resistant class A beta-lactamase KPC-150
        blaKPC-152       NG_242295.1 WP_328703061.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-152
        blaKPC-202       NG_242296.1 WP_328703062.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-202
        blaKPC-203       NG_242297.1 WP_321140136.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-203
        blaKPC-204       NG_242298.1 WP_265432541.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-204
        blaKPC-205       NG_242299.1 WP_322972495.1     inhibitor-resistant class A beta-lactamase KPC-205
        blaKPC-206       NG_242300.1 WP_328703063.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-206
        blaKPC-207       NG_242301.1 WP_328703064.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-207
        blaKPC-208       NG_242302.1 WP_328703065.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-208
        blaOXA-1167      NG_242303.1 WP_328703066.1     OXA-48 family class D beta-lactamase OXA-1167
        blaOXA-1224      NG_242304.1 WP_101663562.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1224
        blaOXA-1225      NG_242305.1 WP_328703067.1     OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-1225
        blaPDC-577       NG_242306.1 WP_328703068.1     inhibitor-resistant extended-spectrum class C beta-lactamase PDC-577
        blaPDC-578       NG_242307.1 WP_328703069.1     class C beta-lactamase PDC-578
        blaPDC-579       NG_242308.1 WP_328703070.1     class C beta-lactamase PDC-579
        blaPDC-580       NG_242309.1 WP_328703071.1     class C beta-lactamase PDC-580
        blaPDC-581       NG_242310.1 WP_328703072.1     class C beta-lactamase PDC-581
        blaSHV-175       NG_242311.1 WP_200525730.1     class A beta-lactamase SHV-175
        blaSHV-233       NG_242312.1 WP_328703073.1     inhibitor-resistant class A beta-lactamase SHV-233
        blaSHV-234       NG_242313.1 WP_328703074.1     inhibitor-resistant class A beta-lactamase SHV-234
        blaSHV-235       NG_242314.1 WP_328703075.1     class A beta-lactamase SHV-235
        blaSHV-236       NG_242315.1 WP_328703076.1     class A beta-lactamase SHV-236
        blaSHV-237       NG_242316.1 WP_328703077.1     class A beta-lactamase SHV-237
        blaSHV-238       NG_242317.1 WP_328703078.1     class A beta-lactamase SHV-238
        blaSHV-239       NG_242318.1 WP_328703079.1     inhibitor-resistant class A beta-lactamase SHV-239
        blaSHV-240       NG_242319.1 WP_064173135.1     inhibitor-resistant class A beta-lactamase SHV-240
        blaSHV-241       NG_242320.1 WP_328703080.1     inhibitor-resistant class A beta-lactamase SHV-241
        blaSHV-242       NG_242321.1 WP_265929472.1     inhibitor-resistant class A beta-lactamase SHV-242
        blaSHV-243       NG_242322.1 WP_328703081.1     class A beta-lactamase SHV-243
        blaVEB-32        NG_242323.1 WP_073350313.1     extended-spectrum class A beta-lactamase VEB-32
        blaVEB-33        NG_242324.1 WP_328703082.1     extended-spectrum class A beta-lactamase VEB-33
        mcr-1.37         NG_242325.1 WP_114429521.1     phosphoethanolamine--lipid A transferase MCR-1.37
        qnrB98           NG_242326.1 WP_149691965.1     quinolone resistance pentapeptide repeat protein QnrB98
    plus AMR AMR
        nimB-Cd          FN545816.1 CBE03766.1          putative 5-nitroimidazole reductase NimB-Cd
    plus VIRULENCE VIRULENCE
        bont_F6          M92906.1 AAA23263.1            botulinum neurotoxin subtype F6
        cssA             U04844.1 AAC45093.1            CS6 fimbrial subunit A CssA
        cseA             AF145205.1 AAD30557.1          C22 fimbrial major subunit CseA
        cswA             AY009096.1 AAK09047.1          CS12 fimbrial major subunit CswA
        csaB             AF296132.1 AAK97135.1          CS4 pilus major pilin CsaB
        csnA             AF438155.1 AAL31637.1          CS20 fimbrial major subunit CsnA
        fotA             AF335469.1 AAO73846.1          CS18 fimbrial major subunit FotA
        csdA             AY288101.1 AAQ19775.1          CS19 fimbria major subunit CsdA
        cosA             AY513487.1 AAS89773.1          PCF071 fimbrial major subunit CosA
        csbA             AY515609.1 AAS89777.1          CS17 fimbrial major subunit CsbA
        cooA             AY536429.1 AAT07441.1          CS1 fimbrial major subunit CooA
        bont_B3          EF028400.1 ABM73977.1          botulinum neurotoxin subtype B3
        bont_E3          EF028403.1 ABM73980.1          botulinum neurotoxin subtype E3
        bont_E2          EF028404.1 ABM73981.1          botulinum neurotoxin subtype E2
        bont_B4          EF051570.1 ABM73987.1          botulinum neurotoxin subtype B4
        bont_DC          EF378947.1 ABP48747.1          botulinum neurotoxin subtype DC
        bont_F1          CP000728.1 ABS41202.1          botulinum neurotoxin subtype F1
        bont_B1          CP000940.1 ACA46990.1          botulinum neurotoxin subtype B1
        bont_A3          CP000963.1 ACA57525.1          botulinum neurotoxin subtype A3
        bont_A5          EU679004.1 ACG50065.1          botulinum neurotoxin subtype A5
        bont_B5          CP001081.1 ACQ51206.1          botulinum neurotoxin subtype B5
        bont_A4          CP001081.1 ACQ51417.1          botulinum neurotoxin subtype A4
        bont_A6          FJ981696.1 ACW83608.1          botulinum neurotoxin subtype A6
        bont_F5          GU213212.1 ADA79560.1          botulinum neurotoxin subtype F5
        bont_F4          GU213221.1 ADA79569.1          botulinum neurotoxin subtype F4
        bont_F3          GU213227.1 ADA79575.1          botulinum neurotoxin subtype F3
        bont_F7          HM746656.1 ADK48765.1          botulinum neurotoxin subtype F7
        bont_E7          JN695729.1 AER11391.1          botulinum neurotoxin subtype E7
        bont_E8          JN695730.1 AER11392.1          botulinum neurotoxin subtype E8
        aalE             JQ434477.1 AFD29291.1          CS23 fimbrial major subunit AalE
        bont_B7          JQ354985.1 AFD33678.1          botulinum neurotoxin subtype B7
        bonA             JX173632.1 AFN27480.1          bongkrekic acid type I polyketide synthase BonA
        bont_B8          JQ964806.1 AFN61309.1          botulinum neurotoxin subtype B8
        bont_A7          JQ954969.1 AFV13854.1          botulinum neurotoxin subtype A7
        bont_E9          JX424534.1 AFV91339.1          botulinum neurotoxin subtype E9
        bont_E12         KF929215.1 AHK10119.1          botulinum neurotoxin subtype E12
        bont_E11         KF861879.1 AII82289.1          botulinum neurotoxin subtype E11
        bont_E10         KF861920.1 AII82330.1          botulinum neurotoxin subtype E10
        bont_A8          KM233166.1 AJA05787.1          botulinum neurotoxin subtype A8
        bont_CD          D49440.1 BAA08418.1            botulinum neurotoxin subtype CD
        bc2l             D63903.1 BAA09942.1            C2 toxin component I
        bont_C1          D90210.1 BAA14235.1            botulinum neurotoxin subtype C1
        bc2h             D88982.1 BAA32537.1            C2 toxin component II
        bont_E5          AB037704.1 BAB03512.1          botulinum neurotoxin subtype E5
        bont_E4          AB088207.1 BAC05434.1          botulinum neurotoxin subtype E4
        bont_B2          AB084152.1 BAC22064.1          botulinum neurotoxin subtype B2
        bont_B6          AB302852.1 BAF91946.1          botulinum neurotoxin subtype B6
        bont_X           AP014696.1 BAQ12790.1          botulinum neurotoxin type X
        cfsA             AJ224079.2 CAA11820.1          CS5 fimbrial major subunit CsfA
        cstB             X16944.1 CAA34816.1            CS3 fimbrial usher protein CstB
        c3bot1           X59040.1 CAA41768.1            C3 toxin
        bont_E1          X62089.1 CAA43999.1            botulinum neurotoxin subtype E1
        cshE             X71971.1 CAA50789.1            CS13 fimbrial major subunit CshE
        bont_A2          X73423.1 CAA51824.1            botulinum neurotoxin subtype A2
        bont_F2          Y13631.1 CAA73972.1            botulinum neurotoxin subtype F2
        cotA             Z47800.1 CAA87761.1            CS2 fimbrial major subunit CotA
        csvA             LR882979.1 CAD5989151.1        CS7 fimbrial major subunit CsvA
        bont_A1          AM412317.1 CAL82360.1          botulinum neurotoxin subtype A1
        bont_E6          AM695752.1 CAM91125.1          botulinum neurotoxin subtype E6
        cblA             AM747721.1 CAR56625.1          cable pilus major pilin CblA
        c3bot2           ABDQ01000009.1 EDS77074.1      C3 toxin
        bont_F8          AUZC01000009.1 KEJ01913.1      botulinum neurotoxin subtype F8
        bont_H           JSCF01000006.1 KGO15617.1      botulinum neurotoxin type H
        bont_G           AYSO01000020.1 KIE44899.1      botulinum neurotoxin type G
        crsA             LGMS01000054.1 OKT93637.1      CS26 fimbrial major subunit CrsA
        fanC             CP026930.2 QHF70768.1          F5 fimbrial major subunit protein FanC
Added point mutations
    core AMR POINT
        ampD_E108STOP    CARBAPENEM Pseudomonas_aeruginosa
        blaOXA-143_A-14G CARBAPENEM Acinetobacter_baumannii
        blaOXA-143_G-42A CARBAPENEM Acinetobacter_baumannii
        blaOXA-61_G-57T  CARBAPENEM Campylobacter
        mexR_Q31STOP     CARBAPENEM Pseudomonas_aeruginosa
        mexR_Q49STOP     CARBAPENEM Pseudomonas_aeruginosa
        mexZ_E8STOP      CARBAPENEM Pseudomonas_aeruginosa
        mexZ_Q103STOP    CARBAPENEM Pseudomonas_aeruginosa
        mexZ_Q134STOP    CARBAPENEM Pseudomonas_aeruginosa
        mexZ_Q69STOP     CARBAPENEM Pseudomonas_aeruginosa
        mexZ_Q95STOP     CARBAPENEM Pseudomonas_aeruginosa
        mexZ_W167STOP    CARBAPENEM Pseudomonas_aeruginosa
        mreE_A694T       CEPHALOSPORIN Clostridioides_difficile
        mreE_A694V       CEPHALOSPORIN Clostridioides_difficile
        mreE_A778V       CEPHALOSPORIN Clostridioides_difficile
        mreE_A795L       CEPHALOSPORIN Clostridioides_difficile
        mreE_A795V       CEPHALOSPORIN Clostridioides_difficile
        mreE_M496V       CEPHALOSPORIN Clostridioides_difficile
        mreE_V497L       CEPHALOSPORIN Clostridioides_difficile
        mreE_Y721C       CEPHALOSPORIN Clostridioides_difficile
        mreE_Y721S       CEPHALOSPORIN Clostridioides_difficile
        nalD_Q114STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_E140STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_E185STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_E32STOP     CARBAPENEM Pseudomonas_aeruginosa
        oprD_E386STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_Q158STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_Q164STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_Q327STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_Q415STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_Q424STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_Q429STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_S278P       CARBAPENEM Pseudomonas_aeruginosa
        oprD_V359L       CARBAPENEM Pseudomonas_aeruginosa
        oprD_W417STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_W6STOP      CARBAPENEM Pseudomonas_aeruginosa
        oprD_Y196STOP    CARBAPENEM Pseudomonas_aeruginosa
        rpoB_Q517QDQ     RIFAMPIN Escherichia
Removed proteins
Removed point mutations
    core AMR POINT
        blaOXA_A-14G     CARBAPENEM Acinetobacter_baumannii
        blaOXA_G-42A     CARBAPENEM Acinetobacter_baumannii
Changed reference gene catalog records
    cfaC AAC41416.1
        pubmed_reference: <empty> -> 25596032
    csuC AAQ20107.1
        gene_family:     cfaC -> csuC
        hierarchy_node:  cfaC -> csuC
        product_name:    CFA/I pilus usher protein CfaC -> CS14 pilus usher protein CsuC
    16S_A1055G NC_000913.3
        pubmed_reference: <empty> -> 16269538
    16S_A1408G NC_000913.3
        pubmed_reference: <empty> -> 11502507
    16S_A1499G NC_000913.3
        pubmed_reference: <empty> -> 16269538
    16S_A1519C NC_000913.3
        pubmed_reference: <empty> -> 10512710
    16S_A1519G NC_000913.3
        pubmed_reference: <empty> -> 10512710
    16S_A1519T NC_000913.3
        pubmed_reference: <empty> -> 10512710
    16S_A523C NC_000913.3
        pubmed_reference: <empty> -> 3054810
    16S_A794G NC_000913.3
        pubmed_reference: <empty> -> 10512710
    16S_A794T NC_000913.3
        pubmed_reference: <empty> -> 10512710
    16S_A964G NC_000913.3
        pubmed_reference: <empty> -> 16269538
    16S_C1054T NC_000913.3
        pubmed_reference: <empty> -> 16269538
    16S_C1066T NC_000913.3
        pubmed_reference: <empty> -> 8127669
    16S_C1192T NC_000913.3
        pubmed_reference: <empty> -> 6330677
    16S_C528T NC_000913.3
        pubmed_reference: <empty> -> 16269538
    16S_G1053A NC_000913.3
        pubmed_reference: <empty> -> 16269538
    16S_G1058C NC_000913.3
        pubmed_reference: <empty> -> 9661007
    16S_G1064A NC_000913.3
        pubmed_reference: <empty> -> 8127669
    16S_G1064C NC_000913.3
        pubmed_reference: <empty> -> 8127669
    16S_G1064T NC_000913.3
        pubmed_reference: <empty> -> 8127669
    16S_G1068A NC_000913.3
        pubmed_reference: <empty> -> 16269538
    16S_G527T NC_000913.3
        pubmed_reference: <empty> -> 16269538
    16S_G926A NC_000913.3
        pubmed_reference: <empty> -> 10512710
    16S_G926C NC_000913.3
        pubmed_reference: <empty> -> 10512710
    16S_G926T NC_000913.3
        pubmed_reference: <empty> -> 10512710
    23S_C2611T NC_004431.1
        pubmed_reference: <empty> -> 1569089
    23S_G2032C NC_004431.1
        pubmed_reference: <empty> -> 10986233
    23S_G2057A NC_004431.1
        pubmed_reference: <empty> -> 3886627
    23S_G2447T NC_004431.1
        pubmed_reference: <empty> -> 10986233
    23S_T754A NC_004431.1
        pubmed_reference: <empty> -> 10027979
    blaKPC-41 WP_148044419.1
        pubmed_reference: 31527032,37255469 -> 31527032,35416703,37255469
    blaKPC-93 WP_243939160.1
        product_name:    inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-93 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-93
        pubmed_reference: <empty> -> 35416703
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaSHV-132 WP_063864620.1
        product_name:    class A beta-lactamase SHV-132 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-132
    blaVIM-1 WP_013263789.1
        pubmed_reference: 10390207,18804966,37255469 -> 10390207,18804966,37255469,38197500
    blaVIM-19 WP_032492472.1
        pubmed_reference: 19917750 -> 19917750,38197500
    blaVIM-29 WP_060589395.1
        pubmed_reference: 23954421 -> 23954421,38197500
    blaVIM-4 WP_032492008.1
        pubmed_reference: 12435718 -> 12435718,38197500
    blaVIM-86 WP_274293093.1
        pubmed_reference: <empty> -> 38197500
    fabI_F203A WP_000506490.1
        pubmed_reference: <empty> -> 27577999
    fabI_F203C WP_000506490.1
        pubmed_reference: <empty> -> 27577999
    fabI_F203L WP_000506490.1
        pubmed_reference: <empty> -> 27577999
    fabI_G93A WP_000506490.1
        pubmed_reference: <empty> -> 27577999
    fabI_G93S WP_000506490.1
        pubmed_reference: <empty> -> 27577999
    fabI_G93V WP_000506490.1
        pubmed_reference: <empty> -> 27577999
    ftsI_F533L WP_003094139.1
        pubmed_reference: 21135211,32071060 -> 21135211,32071060,37823665
    gyrA_A70T WP_002857904.1
        pubmed_reference: <empty> -> 8384814
    gyrA_D85Y WP_002857904.1
        pubmed_reference: <empty> -> 18031331
    gyrA_D90A WP_002857904.1
        pubmed_reference: <empty> -> 8384814
    gyrA_D90T WP_002857904.1
        pubmed_reference: <empty> -> 8384814
    gyrA_S97P WP_001281271.1
        pubmed_reference: 27559761 -> 27559761,29091182
    mcr-9.1 AYW01299.1
        pubmed_reference: 31064835,32513803 -> 31064835,32513803,38031909
    nfsA_K141STOP WP_089631889.1
        pubmed_reference: <empty> -> 26552976
    nfsA_Q44STOP WP_089631889.1
        pubmed_reference: <empty> -> 26552976
    nfsA_R133S WP_089631889.1
        pubmed_reference: <empty> -> 26552976
    nfsA_R15C WP_089631889.1
        pubmed_reference: <empty> -> 18544599
    nfsA_R203C WP_089631889.1
        pubmed_reference: <empty> -> 18544599
    nfsA_R203L WP_089631889.1
        pubmed_reference: <empty> -> 18544599
    nfsA_S33R WP_089631889.1
        pubmed_reference: <empty> -> 18544599
    oprD_Q142STOP WP_003112576.1
        pubmed_reference: 27736752,29681898 -> 27736752,29681898,37823665,37823665
    oprD_S251STOP WP_003112576.1
        pubmed_reference: 31570397 -> 31570397,37823665
    oprD_W138STOP WP_003112576.1
        pubmed_reference: 27736752 -> 27736752,37823665
    oprD_W277STOP WP_003112576.1
        pubmed_reference: 26729493 -> 26729493,37823665
    oprD_W339STOP WP_003112576.1
        pubmed_reference: 35638817 -> 35638817,37823665
    oprD_W65STOP WP_003112576.1
        pubmed_reference: 35638817 -> 35638817,37823665
    parC_A108T WP_001281881.1
        pubmed_reference: <empty> -> 12523629,18500921
    parC_A85T WP_001281881.1
        pubmed_reference: <empty> -> 27620866
    parC_D111H WP_001281881.1
        pubmed_reference: <empty> -> 27620866
    parC_E84A WP_001281881.1
        pubmed_reference: <empty> -> 20638608,12654733
    parC_F60I WP_001281881.1
        pubmed_reference: <empty> -> 18500921
    parC_F60L WP_001281881.1
        pubmed_reference: <empty> -> 18500921
    parC_S129P WP_001281881.1
        pubmed_reference: <empty> -> 27620866
    parC_S80L WP_001281881.1
        pubmed_reference: <empty> -> 8524852
    rpoB_H526Y WP_000263098.1
        pubmed_reference: <empty> -> 3050121
    rpoB_L533P WP_000263098.1
        pubmed_reference: <empty> -> 3050121
    rpoB_Q513L WP_000263098.1
        pubmed_reference: <empty> -> 3050121
    rpoB_Q513P WP_000263098.1
        pubmed_reference: <empty> -> 3050121
    rpoB_R529C WP_000263098.1
        pubmed_reference: <empty> -> 3050121
    rpoB_R529S WP_000263098.1
        pubmed_reference: <empty> -> 3050121
    rpoB_R687H WP_000263098.1
        pubmed_reference: <empty> -> 3050121
    rpoB_S531F WP_000263098.1
        pubmed_reference: <empty> -> 3050121
    rpoB_T563P WP_000263098.1
        pubmed_reference: <empty> -> 3050121
    rpoB_V146F WP_000263098.1
        pubmed_reference: <empty> -> 3050121

Hierarchy nodes added
    core AMR AMR
        aac(6')_E141     aac(6')-E141                   aminoglycoside 6'-N-acetyltransferase AAC(6')-E141
        blaCIM           blaCIB NF041441.1              CIM family subclass B1 metallo-beta-lactamase
        blaPEN-H         blaPEN-H                       PEN-H family class A beta-lactamase
        vanY-M           vanY-M                         D-Ala-D-Ala carboxypeptidase VanY-M
    non-reported VIRULENCE VIRULENCE
        VIRULENCE_Burk
        VIRULENCE_Cbot
        bont
    plus AMR AMR
        nimB-Cd          nimB-Cd                        putative 5-nitroimidazole reductase NimB-Cd
    plus VIRULENCE VIRULENCE
        aalE             aalE                           CS23 fimbrial major subunit AalE
        bc2h             bc2h                           C2 toxin component II
        bc2l             bc2l                           C2 toxin component I
        bonA             bonA                           bongkrekic acid type I polyketide synthase BonA
        bont_A           bont_A                         botulinum neurotoxin type A
        bont_A1          bont_A1                        botulinum neurotoxin subtype A1
        bont_A2          bont_A2                        botulinum neurotoxin subtype A2
        bont_A3          bont_A3                        botulinum neurotoxin subtype A3
        bont_A4          bont_A4                        botulinum neurotoxin subtype A4
        bont_A5          bont_A5                        botulinum neurotoxin subtype A5
        bont_A6          bont_A6                        botulinum neurotoxin subtype A6
        bont_A7          bont_A7                        botulinum neurotoxin subtype A7
        bont_A8          bont_A8                        botulinum neurotoxin subtype A8
        bont_B           bont_B                         botulinum neurotoxin type B
        bont_B1          bont_B1                        botulinum neurotoxin subtype B1
        bont_B2          bont_B2                        botulinum neurotoxin subtype B2
        bont_B3          bont_B3                        botulinum neurotoxin subtype B3
        bont_B4          bont_B4                        botulinum neurotoxin subtype B4
        bont_B5          bont_B5                        botulinum neurotoxin subtype B5
        bont_B6          bont_B6                        botulinum neurotoxin subtype B6
        bont_B7          bont_B7                        botulinum neurotoxin subtype B7
        bont_B8          bont_B8                        botulinum neurotoxin subtype B8
        bont_C           bont_C                         botulinum neurotoxin type C
        bont_C1          bont_C1                        botulinum neurotoxin subtype C1
        bont_CD          bont_CD                        botulinum neurotoxin subtype CD
        bont_D           bont_D                         botulinum neurotoxin type D
        bont_DC          bont_DC                        botulinum neurotoxin subtype DC
        bont_E           bont_E                         botulinum neurotoxin type E
        bont_E1          bont_E1                        botulinum neurotoxin subtype E1
        bont_E10         bont_E10                       botulinum neurotoxin subtype E10
        bont_E11         bont_E11                       botulinum neurotoxin subtype E11
        bont_E12         bont_E12                       botulinum neurotoxin subtype E12
        bont_E2          bont_E2                        botulinum neurotoxin subtype E2
        bont_E3          bont_E3                        botulinum neurotoxin subtype E3
        bont_E4          bont_E4                        botulinum neurotoxin subtype E4
        bont_E5          bont_E5                        botulinum neurotoxin subtype E5
        bont_E6          bont_E6                        botulinum neurotoxin subtype E6
        bont_E7          bont_E7                        botulinum neurotoxin subtype E7
        bont_E8          bont_E8                        botulinum neurotoxin subtype E8
        bont_E9          bont_E9                        botulinum neurotoxin subtype E9
        bont_F           bont_F                         botulinum neurotoxin type F
        bont_F1          bont_F1                        botulinum neurotoxin subtype F1
        bont_F2          bont_F2                        botulinum neurotoxin subtype F2
        bont_F3          bont_F3                        botulinum neurotoxin subtype F3
        bont_F4          bont_F4                        botulinum neurotoxin subtype F4
        bont_F5          bont_F5                        botulinum neurotoxin subtype F5
        bont_F6          bont_F6                        botulinum neurotoxin subtype F6
        bont_F7          bont_F7                        botulinum neurotoxin subtype F7
        bont_F8          bont_F8                        botulinum neurotoxin subtype F8
        bont_G           bont_G                         botulinum neurotoxin type G
        bont_H           bont_H                         botulinum neurotoxin type H
        bont_X           bont_X                         botulinum neurotoxin type X
        c3bot1           c3bot1                         C3 toxin
        c3bot2           c3bot2                         C3 toxin
        cblA_Bc          cblA                           cable pilus major pilin CblA
        cfsA             cfsA                           CS5 fimbrial major subunit CsfA
        cooA             cooA                           CS1 fimbrial major subunit CooA
        cosA             cosA                           PCF071 fimbrial major subunit CosA
        cotA             cotA                           CS2 fimbrial major subunit CotA
        crsA             crsA                           CS26 fimbrial major subunit CrsA
        csaB             csaB                           CS4 pilus major pilin CsaB
        csbA             csbA                           CS17 fimbrial major subunit CsbA
        csdA             csdA                           CS19 fimbria major subunit CsdA
        cseA             cseA                           C22 fimbrial major subunit CseA
        cshE             cshE                           CS13 fimbrial major subunit CshE
        csnA             csnA                           CS20 fimbrial major subunit CsnA
        cssA             cssA                           CS6 fimbrial subunit A CssA
        cstB             cstB                           CS3 fimbrial usher protein CstB
        csuC             csuC                           CS14 pilus usher protein CsuC
        csvA             csvA                           CS7 fimbrial major subunit CsvA
        cswA             cswA                           CS12 fimbrial major subunit CswA
        fanC             fanC                           F5 fimbrial major subunit protein FanC
        fotA             fotA                           CS18 fimbrial major subunit FotA
Hierarchy nodes removed
Changed Hierarchy Nodes
    erm(G)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(G)
        hmm_acc:         <empty> -> NF045543.1


----------------------------------------------------------------------
Changes included in 2023-11-15.1
----------------------------------------------------------------------

Overview:

- 19 new point mutations (and two new --organism options) for Vibrio cholerae,
  Vibrio parahaemolyticus, Vibrio vulnificus, and Klebsiella pneumoniae
- A reorganization and 20 new aminoglycoside modifying enzyme (AME) genes and
  HMMs based on curator review and Lund et al., 2023 (PMID: 37537271). This
  includes a new non-reportable HMM and genes to suppress reporting of some
  cryptic AMEs that would otherwise be identified by new higher-level HMMs.
- Revised subclasses and new citations for some previously included AME genes
- 304 new PubMed references added
- Improved dfrB HMM
- Additional stx subunit sequences based on Lindsey et al. 2023 (PMID:
  37894219). Note that AMRFinderPlus identifies stx proteins and provides some
  subunit type information, but stx type calling requires a more complex
  algorithm and simultaneous investigation of both genes. We are working with
  collaborators towards an algorithm, manuscript, and software to accurately
  determine stx type.
- Two new beta-lactamase genes with allele assignment: blaCDA and blaYOC
- tetA(D) was reassigned to the tet(59) node

Summary:
   Total proteins: 7935
        Core proteins: 6817
        Plus proteins: 1115
   AMR proteins: 6862
   STRESS proteins: 253
   VIRULENCE proteins: 820
   PubMed references: 4170
   Point mutations: 1254
   Point mutation reference sequences: 225
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae,
       Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae,
       Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens,
       Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes, Vibrio_cholerae,
       Vibrio_parahaemolyticus, Vibrio_vulnificus
   HMMs: 728

Updates since release 2023-09-26.1:
   Proteins added: 45
       Core proteins added: 39
       Plus proteins added: 4
   AMR proteins added: 43
   VIRULENCE proteins added: 2
   Alleles added: 21
   PubMed references added: 304
   Point mutations added: 19
   Added organism options: Vibrio_parahaemolyticus, Vibrio_vulnificus
   Reference Gene Catalog entries changed: 276
   Hierarchy nodes added: 30
   Hierarchy nodes changed: 36

Added proteins
    core AMR AMR
        aac(6')-E606     NG_242167.1 WP_000405752.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-E606
        aac(6')-E657     NG_242169.1 WP_024566461.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-E657
        aac(2')-I(A267)  NG_242157.1 WP_025297907.1     aminoglycoside N-acetyltransferase AAC(2')-I(A267)
        aac(3)-C1264     NG_242158.1 WP_034000523.1     aminoglycoside N-acetyltransferase AAC(3)-C1264
        aph(3')-H48      NG_242174.1 WP_034024097.1     aminoglycoside O-phosphotransferase APH(3')-H48
        aac(3)-C322      NG_242159.1 WP_044061792.1     aminoglycoside N-acetyltransferase AAC(3)-C322
        aac(6')-E550     NG_242165.1 WP_058699631.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-E550
        aac(6')-D292     NG_242160.1 WP_058878818.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-D292
        aac(6')-E111     NG_242162.1 WP_065217783.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-E111
        aac(6')-E963     NG_242170.1 WP_104467712.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-E963
        aac(6')-E526     NG_242164.1 WP_128470137.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-E526
        aac(6')-F72      NG_242172.1 WP_172693600.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-F72
        aph(2'')-G141    NG_242173.1 WP_185250308.1     aminoglycoside O-phosphotransferase APH(2')-G141
        aph(3')-I(H957)  NG_242176.1 WP_216562158.1     aminoglycoside O-phosphotransferase APH(3')-I(H957)
        aac(6')-D42      NG_242161.1 WP_318245537.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-D42
        aac(6')-E449     NG_242163.1 WP_318245538.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-E449
        aac(6')-E553     NG_242166.1 WP_318245539.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-E553
        aac(6')-E64      NG_242168.1 WP_318245540.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-E64
        aac(6')-F309     NG_242171.1 WP_318245541.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-F309
        aph(3')-H510     NG_242175.1 WP_318245542.1     aminoglycoside O-phosphotransferase APH(3')-H510
        blaCAM-2         NG_242177.1 WP_318245543.1     subclass B1 metallo-beta-lactamase CAM-2
        blaCDA-1         NG_242178.1 WP_253282916.1     class C beta-lactamase CDA-1
        blaCTX-M-268     NG_242179.1 WP_318245544.1     extended-spectrum class A beta-lactamase CTX-M-268
        blaCTX-M-269     NG_242180.1 WP_318245545.1     extended-spectrum class A beta-lactamase CTX-M-269
        blaDHA-33        NG_242181.1 WP_318245546.1     class C beta-lactamase DHA-33
        blaKPC-137       NG_242182.1 WP_318245547.1     inhibitor-resistant class A beta-lactamase KPC-137
        blaKPC-168       NG_242183.1 WP_318245548.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-168
        blaKPC-176       NG_242184.1 WP_318245549.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-176
        blaKPC-193       NG_242185.1 WP_318245550.1     class A beta-lactamase KPC-193
        blaKPC-194       NG_242186.1 WP_318245551.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-194
        blaKPC-195       NG_242187.1 WP_318245552.1     carbapenem-hydrolyzing class A beta-lactamase KPC-195
        blaKPC-196       NG_242188.1 WP_318245553.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-196
        blaKPC-197       NG_242189.1 WP_316472302.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-197
        blaKPC-201       NG_242190.1 WP_305449896.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-201
        blaOXA-105       NG_242191.1 WP_265760908.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-105
        blaOXA-1223      NG_242192.1 WP_318245554.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1223
        blaYOC-1         NG_242193.1 WP_167809787.1     class C beta-lactamase YOC-1
        dfrB10           NG_242194.1 WP_172688537.1     trimethoprim-resistant dihydrofolate reductase DfrB10
        dfrB11           NG_242195.1 WP_318245555.1     trimethoprim-resistant dihydrofolate reductase DfrB11
    non-reported AMR AMR
        aac(6')-Iaa      AE006468.2 AAL20537.1          aminoglycoside 6'-N-acetyltransferase AAC(6')-Iaa
        aac(6')-Iy       AF144880.1 AAF03531.1          aminoglycoside 6'-N-acetyltransferase AAC(6')-Iy
    plus AMR AMR
        cplR             CP010905.2 AJP12342.1          ABC-F type ribosomal protection protein CplR
        cplR             CP009225.1 AKC61310.1          ABC-F type ribosomal protection protein CplR
    plus VIRULENCE VIRULENCE
        stxA2n           CP113094.1 WAK61649.1          Shiga toxin Stx2n subunit A
        stxA2m           OQ054797.1 WGO76391.1          Shiga toxin Stx2m subunit A
Added point mutations
    core AMR POINT
        ampD_H157Y       CEPHALOSPORIN/TAZOBACTAM Pseudomonas_aeruginosa
        cirA_E133STOP    CEFIDEROCOL Klebsiella_pneumoniae
        ftsI_L367Q       CEFTAZIDIME-AVIBACTAM Klebsiella_pneumoniae
        gyrA_D87N        QUINOLONE Vibrio_cholerae
        gyrA_S83F        QUINOLONE Vibrio_parahaemolyticus
        gyrA_S83I        QUINOLONE Vibrio_cholerae
        gyrA_S83I        QUINOLONE Vibrio_parahaemolyticus
        gyrA_S83I        QUINOLONE Vibrio_vulnificus
        gyrA_S83R        QUINOLONE Vibrio_vulnificus
        lamB_R134P       CEFTAZIDIME-AVIBACTAM Klebsiella_pneumoniae
        lamB_R374S       CEFTAZIDIME-AVIBACTAM Klebsiella_pneumoniae
        parC_S85F        QUINOLONE Vibrio_parahaemolyticus
        parC_S85I        QUINOLONE Vibrio_cholerae
        parC_S85L        QUINOLONE Vibrio_cholerae
        parC_S85L        QUINOLONE Vibrio_parahaemolyticus
        parC_S85L        QUINOLONE Vibrio_vulnificus
        parE_D420N       QUINOLONE Vibrio_cholerae
        parE_P439S       QUINOLONE Vibrio_cholerae
        phoQ_V24G        COLISTIN Klebsiella_pneumoniae
Changed reference gene catalog records
    ariR AAC74250.1
        synonyms:        <empty> -> ymgB
    lpfA-O113 AAP18950.1
        gene_family:     lpfA -> lpfA-O113
    lpfA-O113 AAT76975.1
        gene_family:     lpfA -> lpfA-O113
    lpfA-O113 ACB16424.1
        gene_family:     lpfA -> lpfA-O113
    stxB1e AHJ80154.1
        class:           <empty> -> STX1
        subclass:        <empty> -> STX1E
    stxA1e AHJ80155.1
        class:           <empty> -> STX1
        subclass:        <empty> -> STX1E
    stxB2l CAP17610.1
        gene_family:     stxB2e -> stxB2l
        hierarchy_node:  stxB2e -> stxB2l
        product_name:    Shiga toxin Stx2e subunit B -> Shiga toxin Stx2l subunit B
        subclass:        STX2E -> STX2L
    lpfA-O113 CAV00812.1
        gene_family:     lpfA -> lpfA-O113
    stxA2o EEV0948227.1
        class:           <empty> -> STX2
        subclass:        <empty> -> STX2O
    stxB2o EEV0948228.1
        class:           <empty> -> STX2
        subclass:        <empty> -> STX2O
    stxB2n WAK53219.1
        class:           <empty> -> STX2
        subclass:        <empty> -> STX2N
    stxB2m WGO76392.1
        class:           <empty> -> STX2
        subclass:        <empty> -> STX2M
    dfrA19 WP_000019304.1
        pubmed_reference: <empty> -> 19075060
    cmlA1 WP_000095725.1
        pubmed_reference: <empty> -> 17283193
    vanX-A WP_000402347.1
        pubmed_reference: <empty> -> 17021204
    msr(A) WP_000438874.1
        pubmed_reference: <empty> -> 17986343
    tet(K) WP_000492284.1
        pubmed_reference: <empty> -> 16517273
    vanZ-A WP_000516404.1
        pubmed_reference: <empty> -> 17021204
    tet(M) WP_000691737.1
        pubmed_reference: <empty> -> 19948800
    blaZ WP_000733281.1
        pubmed_reference: <empty> -> 17986343
    blaZ WP_000733287.1
        pubmed_reference: <empty> -> 17986343
    erm(C) WP_001003260.1
        pubmed_reference: <empty> -> 16517273
    cfr WP_001010505.1
        pubmed_reference: 16801432 -> 15471995,16801432
    tet(59) WP_001031679.1
        gene_family:     tetA(D) -> tet(59)
        hierarchy_node:  tetA(D) -> tet(59)
        product_name:    Tet(D)-related tetracycline efflux MFS transporter -> tetracycline efflux MFS transporter Tet(59)
        synonyms:        <empty> -> tet59,tetA(D)
    vanH-A WP_001059542.1
        pubmed_reference: <empty> -> 17021204
    tet(38) WP_001100289.1
        pubmed_reference: <empty> -> 19948800
    tet(38) WP_001100300.1
        pubmed_reference: <empty> -> 17986343
    aac(3)-IIe WP_002063884.1
        pubmed_reference: <empty> -> 12726770
    ant(6)-Ia WP_002294505.1
        pubmed_reference: <empty> -> 19603075
    vanH-B WP_002317268.1
        pubmed_reference: <empty> -> 19029325
    lsa(A) WP_002398829.1
        pubmed_reference: <empty> -> 15616272
    catA WP_002403315.1
        pubmed_reference: 11257023 -> 11257023,11735367
    lsa(A) WP_002411322.1
        pubmed_reference: <empty> -> 15616272
    aad9 WP_002578722.1
        pubmed_reference: <empty> -> 15917546
    tet(32) WP_002602099.1
        pubmed_reference: <empty> -> 17178791
    tet(O/M/O) WP_002872163.1
        pubmed_reference: <empty> -> 15470128
    tet(O) WP_002909882.1
        pubmed_reference: <empty> -> 15917546
    mgt WP_003972830.1
        pubmed_reference: <empty> -> 15984838
    tet(W) WP_004217777.1
        pubmed_reference: <empty> -> 18614524
    aph(3')-IX WP_004861468.1
        product_name:    APH(3') family aminoglycoside O-phosphotransferase -> aminoglycoside O-phosphotransferase APH(3')-IX
    str WP_010711054.1
        pubmed_reference: 11257023 -> 11257023,11735367
    aadA7 WP_010794258.1
        pubmed_reference: <empty> -> 17158944,18391044
    vanW-B WP_010815683.1
        pubmed_reference: <empty> -> 19029325
    bla WP_011053164.1
        pubmed_reference: <empty> -> 15561870
    lsa(B) WP_011133547.1
        pubmed_reference: <empty> -> 15471995
    tet(O) WP_011187228.1
        pubmed_reference: <empty> -> 15470128
    aph(3')-Ib WP_011205810.1
        pubmed_reference: <empty> -> 26604259
    sul2 WP_011270126.1
        pubmed_reference: <empty> -> 18190962
    sul2 WP_011270145.1
        pubmed_reference: <empty> -> 18190962
    aac(3)-I WP_011270148.1
        pubmed_reference: <empty> -> 15995187
    bla WP_011270171.1
        pubmed_reference: <empty> -> 15995187
    sul2 WP_011453052.1
        pubmed_reference: <empty> -> 16670108
    floR WP_011453054.1
        pubmed_reference: <empty> -> 16670108
    aph(3')-IIc WP_012479999.1
        pubmed_reference: <empty> -> 18419807
    aph(6) WP_012480135.1
        pubmed_reference: <empty> -> 18419807
    aac(6')-Iz WP_012481011.1
        pubmed_reference: <empty> -> 18419807
    vanS-B WP_012579101.1
        pubmed_reference: <empty> -> 19029325
    vanX-B WP_012579102.1
        pubmed_reference: <empty> -> 19029325
    tet(O) WP_012669445.1
        pubmed_reference: <empty> -> 16436729
    aph(3')-Ia WP_012695470.1
        pubmed_reference: <empty> -> 19075060
    arr WP_012695486.1
        pubmed_reference: <empty> -> 19921331
    tet(O) WP_012775603.1
        pubmed_reference: <empty> -> 19603075
    tet(B) WP_012881330.1
        pubmed_reference: <empty> -> 16436729
    mef(A) WP_014636304.1
        pubmed_reference: <empty> -> 19258262
    tet(40) WP_015573055.1
        pubmed_reference: <empty> -> 15728946
    tet(O/32/O) WP_015573056.1
        pubmed_reference: 11600392 -> 11600392,15728946
    sul1 WP_019727244.1
        pubmed_reference: <empty> -> 17158944,18391044
    vanH-D WP_023043160.1
        pubmed_reference: <empty> -> 17000737
    vanS-D WP_028530133.1
        pubmed_reference: <empty> -> 17724150
    vanD WP_028530135.1
        pubmed_reference: <empty> -> 17724150
    vanX-D WP_028530136.1
        pubmed_reference: <empty> -> 17724150
    ere(A) WP_032084014.1
        pubmed_reference: <empty> -> 19921331
    aadA2 WP_032490336.1
        pubmed_reference: <empty> -> 16451182,16785718
    sul1 WP_032490794.1
        pubmed_reference: <empty> -> 12654659
    catA2 WP_032490795.1
        pubmed_reference: <empty> -> 12654659
    ant(6)-Ia WP_032491779.1
        pubmed_reference: <empty> -> 17021204
    aph(3')-IIIa WP_032491780.1
        pubmed_reference: <empty> -> 17021204
    aadA1 WP_032491959.1
        pubmed_reference: <empty> -> 17698627
    aadA2 WP_032491964.1
        pubmed_reference: <empty> -> 17698627
    sul1 WP_032491966.1
        pubmed_reference: <empty> -> 17698627
    tet(W) WP_033493020.1
        pubmed_reference: <empty> -> 18614524
    tet(M) WP_041160408.1
        pubmed_reference: <empty> -> 16565156
    tet(59) WP_042846365.1
        synonyms:        tet59 -> tet59,tetA(D)
    dfrA29 WP_045899678.1
        pubmed_reference: <empty> -> 20027306
    vanY-D WP_049898469.1
        pubmed_reference: <empty> -> 17724150
    tet(M) WP_050232631.1
        pubmed_reference: <empty> -> 16304164
    aacA34 WP_052285801.1
        subclass:        AMINOGLYCOSIDE -> KANAMYCIN/TOBRAMYCIN
    bla2 WP_063839880.1
        pubmed_reference: <empty> -> 15561870
    aac(6')-Ib WP_063840280.1
        pubmed_reference: <empty> -> 26604259
    aadA11 WP_063840415.1
        pubmed_reference: <empty> -> 17298366
    aadA21 WP_063840436.1
        pubmed_reference: <empty> -> 17283193
    aadA4 WP_063840444.1
        pubmed_reference: <empty> -> 12726770
    aadA7 WP_063840456.1
        pubmed_reference: <empty> -> 18476779
    aadA9 WP_063840458.1
        pubmed_reference: <empty> -> 17298366
    aph(6)-Id WP_063842184.1
        pubmed_reference: <empty> -> 18676889
    arr WP_063842214.1
        pubmed_reference: <empty> -> 19686278
    catA16 WP_063843221.1
        pubmed_reference: <empty> -> 16304164
    catB3 WP_063843227.1
        pubmed_reference: <empty> -> 18550679
    dfrA1 WP_063844292.1
        pubmed_reference: <empty> -> 15837385
    dfrA12 WP_063844298.1
        pubmed_reference: <empty> -> 16451182,16785718
    dfrA15 WP_063844362.1
        pubmed_reference: <empty> -> 16966396
    dfrA17 WP_063844367.1
        pubmed_reference: <empty> -> 18550679
    dfrA33 WP_063844371.1
        pubmed_reference: <empty> -> 20027306
    floR WP_063845118.1
        pubmed_reference: <empty> -> 16966396
    mef(A) WP_063853591.1
        pubmed_reference: <empty> -> 15563518
    mef(A) WP_063853689.1
        pubmed_reference: <empty> -> 16304164
    mef(A) WP_063853698.1
        pubmed_reference: <empty> -> 19258262
    mef(A) WP_063853705.1
        pubmed_reference: <empty> -> 19258262
    oleD WP_063854495.1
        pubmed_reference: 17376874 -> 15984838,17376874
    sul1 WP_063855066.1
        pubmed_reference: <empty> -> 16339607
    tet(A) WP_063855983.1
        pubmed_reference: <empty> -> 18676889
    tet(M) WP_063856390.1
        pubmed_reference: <empty> -> 15519474
    tet(M) WP_063856391.1
        pubmed_reference: <empty> -> 15519474
    tet(M) WP_063856392.1
        pubmed_reference: <empty> -> 15519474
    tet(M) WP_063856398.1
        pubmed_reference: <empty> -> 16565156
    tet(M) WP_063856399.1
        pubmed_reference: <empty> -> 16565156
    tet(O) WP_063856404.1
        pubmed_reference: <empty> -> 15563518
    tet(O) WP_063856405.1
        pubmed_reference: <empty> -> 15910229
    tet(T) WP_063856413.1
        pubmed_reference: <empty> -> 15910229
    tet(W) WP_063856417.1
        pubmed_reference: <empty> -> 16870752
    tet(W) WP_063856418.1
        pubmed_reference: <empty> -> 16870752
    tet(O/W/32/O) WP_063856419.1
        pubmed_reference: <empty> -> 17967912
    tet(O/W/32/O) WP_063856420.1
        pubmed_reference: <empty> -> 17178791
    tet(O/W/O) WP_063856421.1
        pubmed_reference: <empty> -> 17178791
    tet(W) WP_063856424.1
        pubmed_reference: <empty> -> 18614524
    tet(W) WP_063856425.1
        pubmed_reference: <empty> -> 18614524
    vanA-Pa WP_063856526.1
        pubmed_reference: <empty> -> 15561881
    vanA-Pt WP_063856531.1
        pubmed_reference: <empty> -> 15561881
    vanB WP_063856593.1
        pubmed_reference: 15616278 -> 15616278,15855482
    vanB WP_063856625.1
        pubmed_reference: <empty> -> 19273676
    vanG WP_063856696.1
        pubmed_reference: <empty> -> 16723588
    vanH-Ac1 WP_063856698.1
        pubmed_reference: <empty> -> 16476725
    vanH-B WP_063856701.1
        pubmed_reference: <empty> -> 19273676
    vanR-B WP_063856723.1
        pubmed_reference: 15616278 -> 15616278,15855482
    vanR-D WP_063856727.1
        pubmed_reference: <empty> -> 19258279
    vanS-B WP_063856739.1
        pubmed_reference: <empty> -> 15731199
    vanW-B WP_063856763.1
        pubmed_reference: <empty> -> 15731199
    vanW-B WP_063856765.1
        pubmed_reference: <empty> -> 19273676
    vanX-Ac1 WP_063856768.1
        pubmed_reference: <empty> -> 16476725
    vanX-B WP_063856772.1
        pubmed_reference: <empty> -> 15731199
    vanX-D WP_063856776.1
        pubmed_reference: <empty> -> 19258279
    vanXY WP_063856783.1
        pubmed_reference: <empty> -> 16723588
    vanY-D WP_063856881.1
        pubmed_reference: <empty> -> 17000737
    arr WP_063857694.1
        pubmed_reference: <empty> -> 19686278
    aadA1 WP_071846252.1
        pubmed_reference: <empty> -> 17913715
    aadA1 WP_071846253.1
        pubmed_reference: <empty> -> 17913715
    aacA34 WP_071846255.1
        subclass:        AMINOGLYCOSIDE -> KANAMYCIN/TOBRAMYCIN
    aadA2 WP_071846274.1
        pubmed_reference: <empty> -> 16339607
    ant(2'')-Ia WP_071846303.1
        pubmed_reference: <empty> -> 15837385
    aadA1 WP_071846304.1
        pubmed_reference: <empty> -> 15837385
    aadA1 WP_071846339.1
        pubmed_reference: <empty> -> 16911867
    aadA1 WP_071846340.1
        pubmed_reference: <empty> -> 16911867
    aadA1 WP_071846342.1
        pubmed_reference: <empty> -> 18476779
    aadA1 WP_071846343.1
        pubmed_reference: <empty> -> 18476779
    aadA9 WP_071846344.1
        pubmed_reference: <empty> -> 17298366
    aadA2 WP_071846345.1
        pubmed_reference: <empty> -> 17298366
    aadA3 WP_071846346.1
        pubmed_reference: <empty> -> 18710912
    aadA3 WP_071846364.1
        pubmed_reference: <empty> -> 18710912
    dfrA1 WP_071846366.1
        pubmed_reference: <empty> -> 17913715
    aadA5 WP_071846379.1
        pubmed_reference: <empty> -> 18550679
    aadA5 WP_071846381.1
        pubmed_reference: <empty> -> 18550679
    tet(W/32/O) WP_204313011.1
        pubmed_reference: <empty> -> 17967912
    1 WP_003703066.1
        allele:          <empty> -> 1
    aacA56 WP_045890872.1
        pubmed_reference: <empty> -> 37537271
        subclass:        AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
    blaACT-13 WP_063857735.1
        pubmed_reference: <empty> -> 24267783
    blaACT-20 WP_063857769.1
        pubmed_reference: <empty> -> 24916079
    blaACT-21 WP_063857770.1
        pubmed_reference: <empty> -> 24916079
    blaACT-73 WP_152315464.1
        pubmed_reference: <empty> -> 25022578
    blaADC-112 WP_136512054.1
        pubmed_reference: <empty> -> 18591275
    blaADC-113 WP_136512055.1
        pubmed_reference: <empty> -> 18591275
    blaADC-116 WP_017816757.1
        pubmed_reference: <empty> -> 23723398
    blaAMZ-1 WP_280147732.1
        pubmed_reference: <empty> -> 37808287
    blaCMY-100 WP_063859613.1
        pubmed_reference: <empty> -> 24916079
    blaCMY-101 WP_016155498.1
        pubmed_reference: <empty> -> 24916079
    blaCMY-102 WP_063859625.1
        pubmed_reference: <empty> -> 24916079
    blaCMY-103 WP_063859632.1
        pubmed_reference: <empty> -> 24916079
    blaCMY-89 WP_063859891.1
        pubmed_reference: <empty> -> 24267783
    blaCMY-90 WP_063859909.1
        pubmed_reference: <empty> -> 24267783
    blaCTX-M-138 WP_070064534.1
        pubmed_reference: <empty> -> 24916079
    blaEAM-1 WP_122630825.1
        pubmed_reference: <empty> -> 22850693
    blaECM-1 WP_122630824.1
        pubmed_reference: <empty> -> 22850693
    blaEFM-1 WP_122630822.1
        pubmed_reference: <empty> -> 22850693
    blaELM-1 WP_081853183.1
        pubmed_reference: <empty> -> 22850693
    blaEVM-1 WP_122630823.1
        pubmed_reference: <empty> -> 22850693
    blaKPC-154 WP_309367897.1
        product_name:    class A beta-lactamase KPC-154 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-154
        pubmed_reference: <empty> -> 37877547
    blaLEN-38 WP_136086342.1
        pubmed_reference: <empty> -> 30817987
    blaLEN-39 WP_136026639.1
        pubmed_reference: <empty> -> 30817987
    blaLEN-40 WP_136049560.1
        pubmed_reference: <empty> -> 30817987
    blaLEN-41 WP_100675621.1
        pubmed_reference: <empty> -> 30817987
    blaLEN-42 WP_061154665.1
        pubmed_reference: <empty> -> 30817987
    blaLEN-43 WP_074385924.1
        pubmed_reference: <empty> -> 30817987
    blaOKP-B-16 WP_064183695.1
        pubmed_reference: <empty> -> 30817987
    blaOKP-B-24 WP_156404657.1
        pubmed_reference: <empty> -> 30817987
    blaOKP-C-1 WP_136034107.1
        pubmed_reference: <empty> -> 30817987
    blaOKP-D-1 WP_080897395.1
        pubmed_reference: <empty> -> 30817987
    blaOXA-151 WP_048806429.1
        pubmed_reference: <empty> -> 26349828
    blaOXA-152 WP_063861050.1
        pubmed_reference: <empty> -> 26349828
    blaOXA-153 WP_048627819.1
        pubmed_reference: <empty> -> 26349828
    blaOXA-154 WP_063861062.1
        pubmed_reference: <empty> -> 26349828
    blaOXA-155 WP_063861067.1
        pubmed_reference: <empty> -> 26349828
    blaOXA-156 WP_052266736.1
        pubmed_reference: <empty> -> 26349828
    blaOXA-157 WP_058375744.1
        pubmed_reference: <empty> -> 26349828
    blaOXA-158 WP_063861081.1
        pubmed_reference: <empty> -> 26349828
    blaOXA-159 WP_063861087.1
        pubmed_reference: <empty> -> 26349828
    blaOXA-309 WP_063862593.1
        pubmed_reference: <empty> -> 24267783
    blaOXA-336 WP_063862707.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-338 WP_063862710.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-339 WP_063862711.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-340 WP_057053864.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-341 WP_063862712.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-342 WP_063862713.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-343 WP_063862714.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-344 WP_063862715.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-345 WP_063862716.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-346 WP_063862717.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-374 WP_032051604.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-375 WP_063862741.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-376 WP_063862742.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-377 WP_063862743.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-378 WP_032058439.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-379 WP_063862744.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-380 WP_063862745.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-381 WP_063862746.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-382 WP_063862747.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-383 WP_024438993.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-384 WP_063862748.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-385 WP_063862749.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-386 WP_063862750.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-388 WP_063862752.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-389 WP_063862753.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-390 WP_063862754.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-406 WP_063862763.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-408 WP_063862764.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-409 WP_063862765.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-411 WP_063862766.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-412 WP_063862767.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-413 WP_063862768.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-414 WP_063862769.1
        pubmed_reference: <empty> -> 25616788
    blaOXA-429 WP_063862915.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-430 WP_063862927.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-431 WP_063862945.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-432 WP_063864076.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-433 WP_063864077.1
        pubmed_reference: <empty> -> 28925528
    blaOXA-472 WP_063864095.1
        pubmed_reference: <empty> -> 26315325
    blaOXA-473 WP_063864096.1
        pubmed_reference: <empty> -> 26315325
    blaOXA-474 WP_063864097.1
        pubmed_reference: <empty> -> 26315325
    blaOXA-475 WP_063864098.1
        pubmed_reference: <empty> -> 26315325
    blaOXA-476 WP_063864099.1
        pubmed_reference: <empty> -> 26315325
    blaOXA-477 WP_063864100.1
        pubmed_reference: <empty> -> 26315325
    blaOXA-478 WP_063864101.1
        pubmed_reference: <empty> -> 26315325
    blaOXA-479 WP_063864102.1
        pubmed_reference: <empty> -> 26315325
    blaOXA-485 WP_033954903.1
        pubmed_reference: <empty> -> 26604259
    blaOXA-494 WP_003118452.1
        pubmed_reference: <empty> -> 26604259
    blaOXA-543 WP_058132644.1
        pubmed_reference: 28658322 -> 26604259,28658322
    blaOXA-544 WP_071537493.1
        pubmed_reference: 28658322 -> 26604259,28658322
    blaPDC-30 WP_003110141.1
        pubmed_reference: 36918743 -> 25022578,36918743
    blaPDC-31 WP_016562272.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-34 WP_003137570.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-36 WP_023100808.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-37 WP_023092413.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-38 WP_022580963.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-39 WP_023091031.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-40 WP_063864581.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-42 WP_063864582.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-46 WP_043083525.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-58 WP_063864583.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-60 WP_043089496.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-64 WP_043104614.1
        pubmed_reference: <empty> -> 25022578
    blaPDC-71 WP_031630420.1
        pubmed_reference: <empty> -> 25022578
    blaPEN-A18 WP_105835300.1
        pubmed_reference: <empty> -> 35512733
    blaPEN-A32 WP_105762373.1
        pubmed_reference: <empty> -> 35512733
    blaPEN-A34 WP_105856053.1
        pubmed_reference: <empty> -> 35512733
    blaPEN-A37 WP_088929369.1
        pubmed_reference: <empty> -> 35512733
    blaPEN-A4 WP_105781374.1
        pubmed_reference: <empty> -> 19075063
    blaPEN-B1 WP_109342732.1
        pubmed_reference: <empty> -> 19075063
    rmtD1 WP_019726361.1
        pubmed_reference: <empty> -> 17158944,18391044

Hierarchy nodes added
    core AMR AMR
        aac(2')-I        aac(2')                        aminoglycoside 2'-N-acetyltransferase
        aac(2')-I(A267)  aac(2')-I(A267)                aminoglycoside N-acetyltransferase AAC(2')-I(A267)
        aac(2')-II       aac(2')-II                     aminoglycoside N-acetyltransferase AAC(2')-II
        aac(3)-C1264     aac(3)-C1264                   aminoglycoside N-acetyltransferase AAC(3)-C1264
        aac(3)-C322      aac(3)-C322                    aminoglycoside N-acetyltransferase AAC(3)-C322
        aac(6')-D292     aac(6')-D292                   aminoglycoside 6'-N-acetyltransferase AAC(6')-D292
        aac(6')-D42      aac(6')-D42                    aminoglycoside 6'-N-acetyltransferase AAC(6')-D42
        aac(6')-F309     aac(6')-F309                   aminoglycoside 6'-N-acetyltransferase AAC(6')-F309
        aac(6')-F72      aac(6')-F72                    aminoglycoside 6'-N-acetyltransferase AAC(6')-F72
        aac(6')_E        aac(6') NF043067.1             aminoglycoside 6'-N-acetyltransferase
        aac(6')_E111     aac(6')-E111                   aminoglycoside 6'-N-acetyltransferase AAC(6')-E111
        aac(6')_E449     aac(6')-E449                   aminoglycoside 6'-N-acetyltransferase AAC(6')-E449
        aac(6')_E526     aac(6')-E526                   aminoglycoside 6'-N-acetyltransferase AAC(6')-E526
        aac(6')_E550     aac(6')-E550                   aminoglycoside 6'-N-acetyltransferase AAC(6')-E550
        aac(6')_E553     aac(6')-E553                   aminoglycoside 6'-N-acetyltransferase AAC(6')-E553
        aac(6')_E606     aac(6')-E606                   aminoglycoside 6'-N-acetyltransferase AAC(6')-E606
        aac(6')_E64      aac(6')-E64                    aminoglycoside 6'-N-acetyltransferase AAC(6')-E64
        aac(6')_E657     aac(6')-E657                   aminoglycoside 6'-N-acetyltransferase AAC(6')-E657
        aac(6')_E963     aac(6')-E963                   aminoglycoside 6'-N-acetyltransferase AAC(6')-E963
        aph(2'')-G141    aph(2'')-G141                  aminoglycoside O-phosphotransferase APH(2')-G141
        aph(3')-H48      aph(3')-H48                    aminoglycoside O-phosphotransferase APH(3')-H48
        aph(3')-H510     aph(3')-H510                   aminoglycoside O-phosphotransferase APH(3')-H510
        aph(3')-I(H957)  aph(3')-I(H957)                aminoglycoside O-phosphotransferase APH(3')-I(H957)
        blaCDA           blaCDA                         CDA family class C beta-lactamase
        blaYOC           blaYOC                         YOC family class C beta-lactamase
    non-reported AMR AMR
        aac(6')_Salmo    aac(6') NF000140.3             AAC(6')-Iy/Iaa family aminoglycoside 6'-N-acetyltransferase
    plus AMR AMR
        cplR             cplR NF043038.1                ABC-F type ribosomal protection protein CplR
    plus VIRULENCE VIRULENCE
        stxA2m           stxA2m                         Shiga toxin Stx2m subunit A
        stxA2n           stxA2n                         Shiga toxin Stx2n subunit A
        stxB2l           stxB2l                         Shiga toxin Stx2l subunit B
Hierarchy nodes removed
    core AMR AMR
        tetA(D)          tetA(D)                        Tet(D)-related tetracycline efflux MFS transporter
Changed Hierarchy Nodes
    aac(2')          aminoglycoside 2'-N-acetyltransferase
        node_id:         aac(2') -> aac(2')-I
    aac(2')-IIa      kasugamycin N-acetyltransferase AAC(2')-IIa
        parent_node_id:  aac(2') -> aac(2')-II
    aac(2')-IIb      kasugamycin N-acetyltransferase AAC(2')-IIb
        parent_node_id:  aac(2') -> aac(2')-II
    aac(2')-Ia       aminoglycoside N-acetyltransferase AAC(2')-Ia
        parent_node_id:  aac(2') -> aac(2')-I
    aac(2')-Ib       aminoglycoside N-acetyltransferase AAC(2')-Ib
        parent_node_id:  aac(2') -> aac(2')-I
    aac(2')-Ic       aminoglycoside N-acetyltransferase AAC(2')-Ic
        parent_node_id:  aac(2') -> aac(2')-I
    aac(2')-Id       aminoglycoside N-acetyltransferase AAC(2')-Id
        parent_node_id:  aac(2') -> aac(2')-I
    aac(2')-Ie       aminoglycoside N-acetyltransferase AAC(2')-Ie
        parent_node_id:  aac(2') -> aac(2')-I
    aac(6')-I        AAC(6')-I family aminoglycoside 6'-N-acetyltransferase
        parent_node_id:  aac(6') -> aac(6')_E
    aac(6')-III      tobramycin N-acetyltransferase AAC(6')-III
        parent_node_id:  aac(6') -> aac(6')_E
    aac(6')-Iag      aminoglycoside 6'-N-acetyltransferase AAC(6')-Iag
        parent_node_id:  aac(6') -> aac(6')_E
    aac(6')-Ian      aminoglycoside N-acetyltransferase AAC(6')-Ian
        parent_node_id:  aac(6')-I -> aac(6')
    aac(6')-Ie_fam   AAC(6')-Ie family aminoglycoside N-acetyltransferase
        parent_node_id:  aac(6')-I -> aac(6')
    aac(6')-Im       aminoglycoside N-acetyltransferase AAC(6')-Im
        parent_node_id:  aac(6')-I -> aac(6')
    aac(6')_Serra    aminoglycoside 6'-N-acetyltransferase
        parent_node_id:  aac(6') -> aac(6')_E
    aac(6')_Steno    aminoglycoside 6'-N-acetyltransferase
        parent_node_id:  aac(6') -> aac(6')_E
    aac(6')_Yersi    aminoglycoside 6'-N-acetyltransferase
        parent_node_id:  aac(6') -> aac(6')_E
    aacA10           AAC(6')-I family aminoglycoside 6'-N-acetyltransferase
        parent_node_id:  aac(6')-I -> aac(6')
    aacA34           aminoglycoside 6'-N-acetyltransferase AacA34
        subclass:        AMINOGLYCOSIDE -> KANAMYCIN/TOBRAMYCIN
    aph(3')-IX       aminoglycoside O-phosphotransferase APH(3')-IX
        name:            APH(3') family aminoglycoside O-phosphotransferase -> aminoglycoside O-phosphotransferase APH(3')-IX
    ariR             biofilm/acid-resistance regulator AriR
        synonyms:        <empty> -> ymgB
    blaOXA-PR        class D beta-lactamase
        display_parent:  0 -> 1
    dfrB             trimethoprim-resistant dihydrofolate reductase DfrB
        hmm_acc:         NF000331.1 -> NF000331.2
    lpfA-O113        long polar fimbria major subunit LpfA-O113
        symbol:          lpfA -> lpfA-O113
    pbp              penicillin-binding protein
        display_parent:  0 -> 1
    stxA1e           Shiga toxin Stx1e subunit A
        class:           <empty> -> STX1
        subclass:        <empty> -> STX1E
    stxA2_acd        Shiga toxin Stx2 subunit A, a/c/d subtype
        class:           <empty> -> STX2
        subclass:        <empty> -> STX2
    stxA2_eilk       Shiga toxin Stx2 subunit A, e/i/l/k subtype
        class:           <empty> -> STX2
        subclass:        <empty> -> STX2
    stxA2o           Shiga toxin Stx2o subunit A
        class:           <empty> -> STX2
        subclass:        <empty> -> STX2O
    stxB1e           Shiga toxin Stx1e subunit B
        class:           <empty> -> STX1
        subclass:        <empty> -> STX1E
    stxB2m           Shiga toxin Stx2m subunit B
        class:           <empty> -> STX2
        subclass:        <empty> -> STX2M
    stxB2n           Shiga toxin Stx2n subunit B
        class:           <empty> -> STX2
        subclass:        <empty> -> STX2N
    stxB2o           Shiga toxin Stx2o subunit B
        class:           <empty> -> STX2
        subclass:        <empty> -> STX2O
    tet(30)          tetracycline efflux MFS transporter Tet(30)
        hmm_acc:         <empty> -> NF045486.1
    tet(59)          tetracycline efflux MFS transporter Tet(59)
        synonyms:        tet59 -> tet59,tetA(D)
    tet(62)          tetracycline efflux MFS transporter Tet(62)
        hmm_acc:         <empty> -> NF045488.1

----------------------------------------------------------------------
Changes included in 2023-09-26.1
----------------------------------------------------------------------

Overview:

- 62 new core alleles or new protein sequences
- Several new point mutations including blaTEM-1 promoter mutations. The blaTEM
  promoter mutations are identified with the gene symbol blaTEMp and use the
  coordinate system defined by Sutcliffe (PMID 358200)
- Refined point mutation phenotypes for point mutations already in the database
- Five new HMMs and 6 new hierarchy nodes
- Refined subclasses for cfr genes
- The symbol for the eatA_T450I point mutation is changed to eat(A)_T450I to
  match the protein gene symbol and help differentiate the eat(A) ABC-F type
  ribosomal protection protein from eatA, the unrelated serine protease
  autotransporter toxin. We didn't create the nomenclature we just report it.


NOTE: The format of ReferenceGeneHierarchy.txt has changed; two new columns were added.  See
https://github.com/ncbi/amr/wiki/AMRFinderPlus-database#referencegenehierarchytxt
for information on the format of that file.

Summary:
   Total proteins: 7890
        Core proteins: 6778
        Plus proteins: 1111
   AMR proteins: 6819
   STRESS proteins: 253
   VIRULENCE proteins: 818
   PubMed references: 3866
   Point mutations: 1235
   Point mutation reference sequences: 216
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae,
       Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae,
       Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens,
       Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 723

Updates since release 2023-08-08.2:
   Proteins added: 65
       Core proteins added: 62
       Plus proteins added: 2
   AMR proteins added: 63
   STRESS proteins added: 1
   Alleles added: 51
   PubMed references added: 49
   PubMed references removed: 1
   Point mutations added: 19
   Proteins removed: 0
       Core proteins removed: 0
       Plus proteins removed: 0
   Point mutations removed 0
   Reference Gene Catalog entries changed: 21
   Hierarchy nodes added: 6
   Hierarchy nodes removed: 5
   Hierarchy nodes changed: 9

Added proteins
    core AMR AMR
        fos              NG_231529.1 WP_000777201.1     fosfomycin resistance glutathione transferase FosLL
        blaOCH           NG_231520.1 WP_029376317.1     OCH family extended-spectrum class C beta-lactamase
        erm(55)          NG_231525.1 WP_046361760.1     23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(55)
        erm(56)          NG_231528.1 WP_129546809.1     23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(56)
        blaOCH           NG_231519.1 WP_311033290.1     OCH family extended-spectrum class C beta-lactamase
        blaOCH           NG_231521.1 WP_311033291.1     OCH family extended-spectrum class C beta-lactamase
        blaOCH           NG_231522.1 WP_311033292.1     OCH family extended-spectrum class C beta-lactamase
        blaOCH           NG_231523.1 WP_311033293.1     OCH family extended-spectrum class C beta-lactamase
        blaOCH           NG_231524.1 WP_311033294.1     OCH family extended-spectrum class C beta-lactamase
        erm(55)          NG_231526.1 WP_311033295.1     23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(55)
        erm(55)          NG_231527.1 WP_311033296.1     23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(55)
        blaACT-120       NG_231530.1 WP_311033297.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-120
        blaACT-121       NG_231531.1 WP_311033298.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-121
        blaACT-122       NG_231532.1 WP_311033299.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-122
        blaACT-123       NG_231533.1 WP_311033300.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-123
        blaACT-124       NG_231534.1 WP_311033301.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-124
        blaADC-338       NG_231535.1 WP_279984225.1     extended-spectrum class C beta-lactamase ADC-338
        blaADC-339       NG_231536.1 WP_311033302.1     extended-spectrum class C beta-lactamase ADC-339
        blaADC-340       NG_231537.1 WP_311033303.1     extended-spectrum class C beta-lactamase ADC-340
        blaADC-341       NG_231538.1 WP_311033304.1     extended-spectrum class C beta-lactamase ADC-341
        blaADC-342       NG_231539.1 WP_225519091.1     extended-spectrum class C beta-lactamase ADC-342
        blaADC-343       NG_231540.1 WP_032035727.1     extended-spectrum class C beta-lactamase ADC-343
        blaCMH-13        NG_231541.1 WP_248048813.1     class C beta-lactamase CMH-13
        blaCTX-M-70      NG_231542.1 WP_063860071.1     extended-spectrum class A beta-lactamase CTX-M-70
        blaDHA-31        NG_231543.1 WP_311033305.1     class C beta-lactamase DHA-31
        blaIMP-102       NG_231544.1 WP_311033306.1     subclass B1 metallo-beta-lactamase IMP-102
        blaKPC-154       NG_231545.1 WP_309367897.1     class A beta-lactamase KPC-154
        blaKPC-170       NG_231546.1 WP_311033307.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-170
        blaKPC-185       NG_231547.1 WP_311033308.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-185
        blaKPC-186       NG_231548.1 WP_311033309.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-186
        blaKPC-187       NG_231549.1 WP_311033310.1     inhibitor-resistant class A beta-lactamase KPC-187
        blaKPC-189       NG_231550.1 WP_311033311.1     extended-spectrum class A beta-lactamase KPC-189
        blaKPC-190       NG_231551.1 WP_311033312.1     inhibitor-resistant class A beta-lactamase KPC-190
        blaKPC-191       NG_231552.1 WP_311033313.1     inhibitor-resistant class A beta-lactamase KPC-191
        blaKPC-192       NG_231553.1 WP_311033314.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-192
        blaNDM-61        NG_231554.1 WP_311033315.1     subclass B1 metallo-beta-lactamase NDM-61
        blaOXA-1206      NG_231555.1 WP_284495840.1     class D beta-lactamase OXA-1206
        blaOXA-1214      NG_231556.1 WP_311033316.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1214
        blaOXA-1215      NG_231557.1 WP_275573817.1     OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-1215
        blaOXA-1216      NG_231558.1 WP_311033317.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1216
        blaOXA-1217      NG_231559.1 WP_311033318.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1217
        blaOXA-1218      NG_231560.1 WP_311033319.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1218
        blaOXA-1219      NG_231561.1 WP_311033320.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1219
        blaOXA-1220      NG_231562.1 WP_311033321.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1220
        blaOXA-1222      NG_231563.1 WP_032034809.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1222
        blaPDC-564       NG_231564.1 WP_311033322.1     class C beta-lactamase PDC-564
        blaPDC-565       NG_231565.1 WP_262961480.1     class C beta-lactamase PDC-565
        blaPDC-566       NG_231566.1 WP_311033323.1     class C beta-lactamase PDC-566
        blaPDC-567       NG_231567.1 WP_311033324.1     class C beta-lactamase PDC-567
        blaPDC-568       NG_231568.1 WP_311033325.1     class C beta-lactamase PDC-568
        blaPDC-569       NG_231569.1 WP_311033326.1     class C beta-lactamase PDC-569
        blaPDC-570       NG_231570.1 WP_311033327.1     class C beta-lactamase PDC-570
        blaPDC-571       NG_231571.1 WP_311033328.1     class C beta-lactamase PDC-571
        blaPDC-572       NG_231572.1 WP_114012592.1     class C beta-lactamase PDC-572
        blaPDC-573       NG_231573.1 WP_311033329.1     class C beta-lactamase PDC-573
        blaPDC-574       NG_231574.1 WP_311033330.1     class C beta-lactamase PDC-574
        blaPDC-575       NG_231575.1 WP_311033331.1     class C beta-lactamase PDC-575
        blaPDC-576       NG_231576.1 WP_209038818.1     class C beta-lactamase PDC-576
        mcr-1.36         NG_231577.1 WP_311033332.1     phosphoethanolamine--lipid A transferase MCR-1.36
        mcr-4.8          NG_231578.1 WP_311033333.1     phosphoethanolamine--lipid A transferase MCR-4.8
        mcr-5.5          NG_231579.1 WP_311033334.1     phosphoethanolamine--lipid A transferase MCR-5.5
        qnrB84           NG_231580.1 WP_284957973.1     quinolone resistance pentapeptide repeat protein QnrB84
    plus AMR AMR
        vanR-Cd          NZ_CP011847.1 WP_003436401.1   vancomycin resistance response regulator transcription factor VanR-G-Cd
    plus STRESS HEAT
        clpL             CP001603.1 ADB69780.1          ATP-dependent protease ClpL
Added point mutations
    core AMR POINT
        baeR_S104N       CEFIDEROCOL Acinetobacter_baumannii
        baeS_D89V        CEFIDEROCOL Acinetobacter_baumannii
        blaTEMp_C141G    AMOXICILLIN-CLAVULANIC ACID/PIPERACILLIN-TAZOBACTAM/TICARCILLIN-CLAVULANIC ACID Escherichia
        blaTEMp_C32T     AMOXICILLIN-CLAVULANIC ACID/PIPERACILLIN-TAZOBACTAM/TICARCILLIN-CLAVULANIC ACID Escherichia
        blaTEMp_G162T    AMOXICILLIN-CLAVULANIC ACID/PIPERACILLIN-TAZOBACTAM/TICARCILLIN-CLAVULANIC ACID Escherichia
        dacB_I356A       CEPHALOSPORIN Pseudomonas_aeruginosa
        eat(A)_T450I     PLEUROMUTILIN Enterococcus_faecium
        ftsI_T526S       SULBACTAM-DURLOBACTAM Acinetobacter_baumannii
        mexR_Q94STOP     CEPHALOSPORIN Pseudomonas_aeruginosa
        rpoB_D492Y       RIFAXIMIN Clostridioides_difficile
        rpoB_G510R       RIFAXIMIN Clostridioides_difficile
        rpoB_H502R       RIFAXIMIN Clostridioides_difficile
        rpoB_L584F       RIFAXIMIN Clostridioides_difficile
        rpoB_Q489L       RIFAXIMIN Clostridioides_difficile
        rpoB_R505L       RIFAXIMIN Clostridioides_difficile
        rpoB_S488Y       RIFAXIMIN Clostridioides_difficile
        rpoB_S507L       RIFAXIMIN Clostridioides_difficile
        rpsJ_Y58D        TIGECYCLINE Staphylococcus_aureus
        vanR-Cd_T115A    VANCOMYCIN Clostridioides_difficile
Changed reference gene catalog records
    cfr WP_001010505.1
        class:           <empty> -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        pubmed_reference: <empty> -> 16801432
        subclass:        CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMULIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN B/TIAMULIN/VIRGINIAMYCIN
    cfr(B) WP_002349981.1
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        pubmed_reference: <empty> -> 26248384
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/RETAPAMULIN/STREPTOGRAMIN B/VIRGINIAMYCIN
    cfr(B) WP_002405682.1
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/RETAPAMULIN/STREPTOGRAMIN B/VIRGINIAMYCIN
    cfr WP_011987126.1
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN A/TIAMULIN
    cfr WP_032491462.1
        class:           <empty> -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMULIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN B/TIAMULIN/VIRGINIAMYCIN
    cfr(E) WP_105119688.1
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        pubmed_reference: <empty> -> 31685464
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> LINCOSAMIDE/LINEZOLID/THIAMPHENICOL/TIAMULIN/VIRGINIAMYCIN
    cfr(D) WP_105459893.1
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        pubmed_reference: <empty> -> 32277823
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/STREPTOGRAMIN B/TEDIZOLID/TIAMULIN
    cfr(B) WP_111690897.1
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/RETAPAMULIN/STREPTOGRAMIN B/VIRGINIAMYCIN
    cfr(C) WP_111690898.1
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        pubmed_reference: <empty> -> 28186558
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN/TIAMULIN
    blaAFM-1 WP_069953510.1
        pubmed_reference: <empty> -> 34545931,34826621
    blaAFM-2 WP_204376224.1
        pubmed_reference: <empty> -> 34826621
    blaAFM-3 WP_211862582.1
        pubmed_reference: <empty> -> 34826621
    blaKPC-31 WP_073668892.1
        pubmed_reference: 34339281 -> 33915286,34339281,36964710
        subclass:        CEPHALOSPORIN -> CEFIDEROCOL/CEPHALOSPORIN
    blaKPC-62 WP_204376229.1
        pubmed_reference: 33775814,36964710 -> 33775814,33915286,36964710
        subclass:        CEPHALOSPORIN -> CEFIDEROCOL/CEPHALOSPORIN
    blaOXA-1203 WP_281441144.1
        curated_refseq_start: Yes -> No
        genbank_protein_accession: <empty> -> WMF72384.1
    blaOXY_G-34A NZ_CP026715.1
        product_name:    blaOXY  promoter region -> blaOXY promoter region
    blaOXY_G-38T NZ_CP026715.1
        product_name:    blaOXY  promoter region -> blaOXY promoter region
    blaOXY_T-58A NZ_CP026715.1
        product_name:    blaOXY  promoter region -> blaOXY promoter region
    blaOXY_T-67C NZ_CP026715.1
        product_name:    blaOXY  promoter region -> blaOXY promoter region
    ftsI_A515V WP_000227936.1
        pubmed_reference: 29547094 -> 29547094,31988095,35127562,35618210
        subclass:        CARBAPENEM -> CARBAPENEM/SULBACTAM-DURLOBACTAM
    ftsI_N337NYRIN WP_000642196.1
        pubmed_reference: 25634992,32988825 -> 25634992,32988825,37610183
        subclass:        AZTREONAM -> AZTREONAM/CEFIDEROCOL

Hierarchy nodes added
    core AMR AMR
        blaOXA-1206_fam  blaOXA                         OXA-1206 family class D beta-lactamase
        blaOXA-837_fam   blaOXA NF042983.1              OXA-837 family class D beta-lactamase
        erm(55)          erm(55) NF042938.1             23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(55)
        erm(56)          erm(56)                        23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(56)
        fosLL            fos NF033405.1                 fosfomycin resistance glutathione transferase FosLL
    plus STRESS HEAT
        clpL             clpL                           ATP-dependent protease ClpL
Hierarchy nodes removed
    non-reported AMR AMR-SUSCEPTIBLE
        AMR-SUSCEPTIBLE                                 Families implicated in adaptive resistance by mutation
        pbp              pbp                            penicillin-binding protein
        pbp1a            pbp1a                          penicillin-binding protein
        pbp2b            pbp2b                          penicillin-binding protein
        pbp2x            pbp2x                          penicillin-binding protein
Changed Hierarchy Nodes
    SMR_efflux_emrE  multidrug efflux SMR transporter EmrE
        hmm_acc:         NF000336.1 -> NF042984.1
    cfr              23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr
        subclass:        PHENICOL/CLINDAMYCIN/LINEZOLID/TIAMULIN/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN B/TIAMULIN/VIRGINIAMYCIN
    cfr(B)           23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(B)
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/RETAPAMULIN/STREPTOGRAMIN B/VIRGINIAMYCIN
    cfr(C)           23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(C)
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN/TIAMULIN
    cfr(D)           23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(D)
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/LINEZOLID/STREPTOGRAMIN B/TEDIZOLID/TIAMULIN
    cfr(E)           23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(E)
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> LINCOSAMIDE/LINEZOLID/THIAMPHENICOL/TIAMULIN/VIRGINIAMYCIN
    cfr-Cb           Cfr family 23S rRNA (adenine(2503)-C(8))-methyltransferase
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CHLORAMPHENICOL/CLINDAMYCIN/FLORFENICOL/LINEZOLID/STREPTOGRAMIN A/TIAMULIN
    eat(A)           ABC-F type ribosomal protection protein Eat(A)
        name:            ABC-F type ribosomal protection-like protein Eat(A) -> ABC-F type ribosomal protection protein Eat(A)
    erm(46)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(46)
        hmm_acc:         <empty> -> NF042988.1


----------------------------------------------------------------------
Changes included in 2023-08-08.2
----------------------------------------------------------------------
Overview:

- A major review and revision of macrolide / lincosamide / pleuromutilin / streptogramin class and subclass designations
- Additional phenotype curation of class/subclass and product name for some blaOXA genes and other beta-lactamases
- As usual, new named alleles for those genes whose allele nomenclature NCBI curates

Summary:
   Total proteins: 7827
        Core proteins: 6716
        Plus proteins: 1110
   AMR proteins: 6757
   STRESS proteins: 252
   VIRULENCE proteins: 818
   PubMed references: 3818
   Point mutations: 1217
   Point mutation reference sequences: 211
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae,
       Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae,
       Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens,
       Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 719

Updates since release 2023-07-13.2:
   Proteins added: 25
       Core proteins added: 25
       Plus proteins added: 0
   AMR proteins added: 25
   Alleles added: 24
   PubMed references added: 295
   Point mutations added: 53
   Reference Gene Catalog entries changed: 494
   Hierarchy nodes changed: 84

Added proteins
    core AMR AMR
        blaL1            NG_228664.1 WP_304486996.1     L1 family subclass B3 metallo-beta-lactamase
        blaADC-336       NG_228665.1 WP_057690145.1     extended-spectrum class C beta-lactamase ADC-336
        blaADC-337       NG_228666.1 WP_304486997.1     extended-spectrum class C beta-lactamase ADC-337
        blaBIC-2         NG_228667.1 WP_304486998.1     carbapenem-hydrolyzing class A beta-lactamase BIC-2
        blaCTX-M-266     NG_228668.1 WP_304486999.1     extended-spectrum class A beta-lactamase CTX-M-266
        blaCTX-M-267     NG_228669.1 WP_072643680.1     extended-spectrum class A beta-lactamase CTX-M-267
        blaKPC-158       NG_228670.1 WP_304487000.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-158
        blaKPC-181       NG_228671.1 WP_163591930.1     carbapenem-hydrolyzing class A beta-lactamase KPC-181
        blaKPC-182       NG_228672.1 WP_304487001.1     carbapenem-hydrolyzing class A beta-lactamase KPC-182
        blaKPC-183       NG_228673.1 WP_304487002.1     carbapenem-hydrolyzing class A beta-lactamase KPC-183
        blaKPC-184       NG_228674.1 WP_304487003.1     carbapenem-hydrolyzing class A beta-lactamase KPC-184
        blaOXA-1211      NG_228675.1 WP_304487004.1     OXA-48 family class D beta-lactamase OXA-1211
        blaOXA-1212      NG_228676.1 WP_304487005.1     OXA-48 family class D beta-lactamase OXA-1212
        blaOXA-1213      NG_228677.1 WP_304487006.1     OXA-48 family class D beta-lactamase OXA-1213
        blaPDC-554       NG_228678.1 WP_304487007.1     class C beta-lactamase PDC-554
        blaPDC-555       NG_228679.1 WP_304487008.1     class C beta-lactamase PDC-555
        blaPDC-556       NG_228680.1 WP_304487009.1     class C beta-lactamase PDC-556
        blaPDC-557       NG_228681.1 WP_304487010.1     class C beta-lactamase PDC-557
        blaPDC-558       NG_228682.1 WP_304487011.1     class C beta-lactamase PDC-558
        blaPDC-559       NG_228683.1 WP_304487012.1     class C beta-lactamase PDC-559
        blaPDC-560       NG_228684.1 WP_304487013.1     class C beta-lactamase PDC-560
        blaPDC-561       NG_228685.1 WP_304487014.1     class C beta-lactamase PDC-561
        blaPDC-562       NG_228686.1 WP_304487015.1     class C beta-lactamase PDC-562
        blaPDC-563       NG_228687.1 WP_304487016.1     class C beta-lactamase PDC-563
        blaSHV-232       NG_228688.1 WP_087834333.1     class A beta-lactamase SHV-232
Added point mutations
    core AMR POINT
        dfrB_A135T       TRIMETHOPRIM Staphylococcus_aureus
        dfrB_L25I        TRIMETHOPRIM Staphylococcus_aureus
        folP_A184V       SULFONAMIDE Staphylococcus_aureus
        folP_E208K       SULFONAMIDE Staphylococcus_aureus
        folP_E258EKE     SULFONAMIDE Staphylococcus_aureus
        folP_F17L        SULFONAMIDE Staphylococcus_aureus
        folP_S18L        SULFONAMIDE Staphylococcus_aureus
        folP_T51M        SULFONAMIDE Staphylococcus_aureus
        nfsA_E75STOP     NITROFURANTOIN Escherichia
        nfsA_G126R       NITROFURANTOIN Escherichia
        nfsA_G154E       NITROFURANTOIN Escherichia
        nfsA_H11Y        NITROFURANTOIN Escherichia
        nfsA_Q113STOP    NITROFURANTOIN Escherichia
        nfsA_Q67STOP     NITROFURANTOIN Escherichia
        nfsA_W159STOP    NITROFURANTOIN Escherichia
        nfsB_F84S        NITROFURANTOIN Escherichia
        nfsB_G192D       NITROFURANTOIN Escherichia
        nfsB_G192S       NITROFURANTOIN Escherichia
        nfsB_W94STOP     NITROFURANTOIN Escherichia
        ompC_Q171STOP    CARBAPENEM Escherichia
        ompC_Q82STOP     CARBAPENEM Escherichia
        ompF_L15STOP     CARBAPENEM Escherichia
        ompF_Q88STOP     CARBAPENEM Escherichia
        ompK36_E87STOP   CARBAPENEM Klebsiella_pneumoniae
        ompK36_L307STOP  CARBAPENEM Klebsiella_pneumoniae
        ompK36_Q313STOP  CARBAPENEM Klebsiella_pneumoniae
        ompK36_Q66STOP   CARBAPENEM Klebsiella_pneumoniae
        ompK36_Q70STOP   CARBAPENEM Klebsiella_pneumoniae
        parR_M59I        COLISTIN Pseudomonas_aeruginosa
        phoQ_D433STOP    COLISTIN Pseudomonas_aeruginosa
        phoQ_I421STOP    COLISTIN Pseudomonas_aeruginosa
        phoQ_LG364del    COLISTIN Pseudomonas_aeruginosa
        phoQ_N104I       COLISTIN Pseudomonas_aeruginosa
        phoQ_V152STOP    COLISTIN Pseudomonas_aeruginosa
        pmrA_E8D         COLISTIN Acinetobacter_baumannii
        pmrA_M12I        COLISTIN Acinetobacter_baumannii
        pmrB_A227V       COLISTIN Acinetobacter_baumannii
        pmrB_A248T       COLISTIN Pseudomonas_aeruginosa
        pmrB_G315D       COLISTIN Acinetobacter_baumannii
        pmrB_H340R       COLISTIN Pseudomonas_aeruginosa
        pmrB_I164F       COLISTIN Acinetobacter_baumannii
        pmrB_P170L       COLISTIN Acinetobacter_baumannii
        pmrB_P233S       COLISTIN Acinetobacter_baumannii
        pmrB_P233T       COLISTIN Acinetobacter_baumannii
        pmrB_Q270P       COLISTIN Acinetobacter_baumannii
        pmrB_R231L       COLISTIN Acinetobacter_baumannii
        pmrB_R263L       COLISTIN Acinetobacter_baumannii
        pmrB_S17R        COLISTIN Acinetobacter_baumannii
        pmrB_S257N       COLISTIN Pseudomonas_aeruginosa
        pmrB_T232I       COLISTIN Acinetobacter_baumannii
        pmrB_T235I       COLISTIN Acinetobacter_baumannii
        pmrB_T343A       COLISTIN Pseudomonas_aeruginosa
        pmrB_V15I        COLISTIN Pseudomonas_aeruginosa
Changed reference gene catalog records
    mph(B) WP_000031017.1
        pubmed_reference: <empty> -> 17302923
        subclass:        MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    msr(E) WP_000052512.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        pubmed_reference: 23114767 -> 23114767,29712846
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN
    mph(E) WP_000155092.1
        pubmed_reference: <empty> -> 15155196,17261525
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mph(C) WP_000196697.1
        pubmed_reference: <empty> -> 17302923
        subclass:        MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    mph(A) WP_000219391.1
        pubmed_reference: <empty> -> 8619599,17302923
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    mef(A) WP_000417517.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_000417519.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    msr(D) WP_000420313.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        pubmed_reference: 11398110 -> 11398110,26531240
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    msr(D) WP_000420317.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 26531240
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    msr(A) WP_000438874.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B
    erm(A) WP_000810833.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN
    erm(C) WP_001003260.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(C) WP_001003263.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: 3087948 -> 3087948,6783733
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(C) WP_001003264.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    cfr WP_001010505.1
        subclass:        CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMUTILIN -> CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMULIN
    erm(B) WP_001038790.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 104975,8878614
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(B) WP_001038792.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 11230937
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(B) WP_001038795.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 7514148
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(A) WP_001072197.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        pubmed_reference: <empty> -> 3004956
        subclass:        MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN
    erm(A) WP_001072201.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN
    erm(B) WP_002292226.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    msr(C) WP_002314314.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(B) WP_002321849.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 23442208
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(T) WP_002345002.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 16189118
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    msr(A) WP_002447408.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B
    erm(F) WP_002682030.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/MACROLIDE/STREPTOGRAMIN
    erm(D) WP_003183781.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN
    vmlR WP_003234144.1
        class:           MACROLIDE/PLEUROMUTILIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/STREPTOGRAMIN/TIAMULIN -> LINCOMYCIN/TIAMULIN/VIRGINIAMYCIN M
    mphK WP_003246254.1
        subclass:        MACROLIDE -> TELITHROMYCIN/TYLOSIN
    aac(2')-Ib WP_003881640.1
        subclass:        GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN
    aac(2')-Ic WP_003899880.1
        subclass:        GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN
    erm(37) WP_003900446.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        pubmed_reference: <empty> -> 14693532,16801446
        subclass:        MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN
    mgt WP_003972830.1
        subclass:        MACROLIDE -> ERYTHROMYCIN/TYLOSIN
    erm(O) WP_003972831.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOMYCIN/PRISTINAMYCIN/TYLOSIN
    aac(2')-Ia WP_004918308.1
        subclass:        GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN
    erm(35) WP_006745469.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    erm(Q) WP_007286427.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN
    erm(C) WP_007410443.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 6938954
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(E) WP_009950391.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN
    erm(C) WP_010889933.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: 3084450,3091582 -> 3084450,3091582,6271735
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(K) WP_010896559.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 36511701
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    aac(2')-Ie WP_010908954.1
        subclass:        GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN
    erm(B) WP_011018369.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(T) WP_011100845.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(X) WP_011116967.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(T) WP_011117197.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(X) WP_011117480.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(33) WP_011133550.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        pubmed_reference: 12384375 -> 11864966,12384375
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN
    erm(X) WP_011152925.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 14576111
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(C) WP_011276921.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(C) WP_011282421.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(C) WP_011382144.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    aac(2')-Id WP_011726942.1
        subclass:        GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN
    erm(B) WP_011861426.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    mef(A) WP_012102963.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    erm(C) WP_014158490.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(42) WP_014325825.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    mph(E) WP_014325835.1
        pubmed_reference: <empty> -> 15155196,17261525
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mph(G) WP_014386803.1
        pubmed_reference: <empty> -> 25765542
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(C) WP_014386804.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    erm(G) WP_014387027.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    mef(A) WP_014636304.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    tva(B) WP_014936356.1
        subclass:        PLEUROMUTILIN/STREPTOGRAMIN -> TIAMULIN
    ere(A) WP_015059985.1
        pubmed_reference: <empty> -> 33741980
    erm(36) WP_015345217.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    ere(D) WP_015345560.1
        pubmed_reference: <empty> -> 26107936,33741980
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mphH WP_015776248.1
        pubmed_reference: <empty> -> 29317655
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TYLOSIN
    mef(A) WP_018374806.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    erm(49) WP_019728092.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        pubmed_reference: 23882264 -> 23882264,29500262
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    mph(F) WP_021263608.1
        pubmed_reference: <empty> -> 17101677
        subclass:        MACROLIDE -> ERYTHROMYCIN
    ere(A) WP_021566672.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mphN WP_024127776.1
        pubmed_reference: <empty> -> 24362420
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_024127829.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    erm(D) WP_025811090.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN
    oleI WP_030778152.1
        subclass:        MACROLIDE -> OLEANDOMYCIN
    erm(54) WP_031885508.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        pubmed_reference: <empty> -> 35639577
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    ere(A) WP_032084014.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    erm(X) WP_032488331.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 2110657
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN
    ere(B) WP_032488343.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    erm(F) WP_032488512.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/MACROLIDE/STREPTOGRAMIN
    erm(C) WP_032489009.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(C) WP_032489010.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(C) WP_032489011.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(C) WP_032489016.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(B) WP_032489723.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    ere(A) WP_032490532.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    cfr WP_032491462.1
        subclass:        CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMUTILIN -> CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMULIN
    mef(B) WP_032492336.1
        pubmed_reference: <empty> -> 19131424
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN
    erm(C) WP_032492416.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(40) WP_036428783.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN
    erm(39) WP_038563636.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN
    erm(44)v WP_041079981.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        pubmed_reference: <empty> -> 27799208
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    erm(B) WP_041152457.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(N) WP_050364506.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 30023575
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(42) WP_052259183.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    srm(B) WP_053138477.1
        subclass:        MACROLIDE -> SPIRAMYCIN
    erm(O) WP_053138973.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 10517588
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOMYCIN/PRISTINAMYCIN/TYLOSIN
    mgt WP_053138975.1
        subclass:        MACROLIDE -> ERYTHROMYCIN/TYLOSIN
    erm(30) WP_055641627.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 9770448
        subclass:        MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    mef(A) WP_058621816.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    erm(Z) WP_063796790.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    ere(A) WP_063844484.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    ere(A) WP_063844485.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    ere(B) WP_063844486.1
        pubmed_reference: <empty> -> 27786586
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    erm(31) WP_063844492.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 9770448
        subclass:        MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    erm(34) WP_063844504.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN
    erm(38) WP_063844518.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        pubmed_reference: 16127056 -> 14506008,16127056
        subclass:        MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN
    erm(43) WP_063844520.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN
    erm(44) WP_063844521.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: 27799208 -> 25092709,27799208
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN
    erm(45) WP_063844522.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN
    erm(B) WP_063844601.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 7486927
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(B) WP_063844614.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(B) WP_063844619.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: 2832378 -> 2832378,3541783
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(C) WP_063844768.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(D) WP_063844769.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN
    erm(E) WP_063844770.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN
    erm(F) WP_063844771.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/MACROLIDE/STREPTOGRAMIN
    erm(F) WP_063844773.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/MACROLIDE/STREPTOGRAMIN
    erm(G) WP_063844787.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(G) WP_063844791.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(H) WP_063844794.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOMYCIN/TYLOSIN/VERNAMYCIN B
    erm(R) WP_063844815.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    erm(S) WP_063844819.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/OSTREOGRYCIN/TYLOSIN
    erm(T) WP_063844825.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(B) WP_063844850.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 11600385
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(U) WP_063844854.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 8577249
        subclass:        MACROLIDE -> LINCOMYCIN/MACROLIDE/STREPTOGRAMIN
    erm(U) WP_063844861.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> LINCOMYCIN/MACROLIDE/STREPTOGRAMIN
    erm(V) WP_063844868.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/TYLOSIN/VERNAMYCIN B
    erm(W) WP_063844871.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(X) WP_063844879.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(X) WP_063844889.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(X) WP_063844894.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(X) WP_063844922.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(Y) WP_063844932.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: 9809423 -> 9809423,11751136
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    mef(A) WP_063853554.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853563.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853574.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853591.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853602.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853625.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853632.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853638.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853648.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853682.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853689.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853698.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853705.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(A) WP_063853713.1
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mgt WP_063853740.1
        subclass:        MACROLIDE -> ERYTHROMYCIN/TYLOSIN
    mph(A) WP_063853854.1
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    mph(A) WP_063853866.1
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    mph(C) WP_063853881.1
        pubmed_reference: 9809423 -> 9809423,17302923
        subclass:        MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    mph(C) WP_063853892.1
        pubmed_reference: <empty> -> 17302923
        subclass:        MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    mph(C) WP_063854131.1
        pubmed_reference: 17005735 -> 17005735,17302923
        subclass:        MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    mph(C) WP_063854137.1
        pubmed_reference: 17005735 -> 17005735,17302923
        subclass:        MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    mph(C) WP_063854150.1
        pubmed_reference: 17005735 -> 17005735,17302923
        subclass:        MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    msr(A) WP_063854312.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B
    msr(A) WP_063854317.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B
    msr(A) WP_063854341.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B
    msr(C) WP_063854349.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    myrA WP_063854489.1
        subclass:        MACROLIDE -> TYLOSIN
    ole(B) WP_063854494.1
        subclass:        MACROLIDE -> OLEANDOMYCIN
    oleD WP_063854495.1
        pubmed_reference: <empty> -> 17376874
        subclass:        MACROLIDE -> ERYTHROMYCIN/OLEANDOMYCIN/TYLOSIN
    tlr(C) WP_063856491.1
        subclass:        MACROLIDE -> TYLOSIN
    mphJ WP_087349244.1
        pubmed_reference: <empty> -> 29259290
    erm(46) WP_087587931.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: 25779586 -> 25779586,26377866
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/VIRGINIAMYCIN
    erm(47) WP_087587932.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN
    erm(48) WP_087587948.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/PRISTINAMYCIN
    msr(G) WP_101035417.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 33118027
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/PRISTINAMYCIN
    mef(F) WP_101035418.1
        pubmed_reference: <empty> -> 33118027
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN
    erm(51) WP_131386768.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        pubmed_reference: <empty> -> 32291839
        subclass:        MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/VIRGINIAMYCIN
    msrH WP_138070341.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/PRISTINAMYCIN
    tva(A) WP_151874537.1
        subclass:        PLEUROMUTILIN/STREPTOGRAMIN -> TIAMULIN
    msrF WP_164941513.1
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/PRISTINAMYCIN
    erm(50) WP_176453837.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        pubmed_reference: <empty> -> 31844016
        subclass:        MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN
    estT WP_185148407.1
        pubmed_reference: <empty> -> 36791107
        subclass:        MACROLIDE -> TYLOSIN
    mef(F) WP_188020219.1
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN
    23S_C658T NZ_CP019870.1
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
    blaAIM-1 WP_063857820.1
        pubmed_reference: 22985886 -> 22985886,37255469
    blaBEL-1 WP_063857830.1
        pubmed_reference: 16127048 -> 16127048,37255469
    blaBEL-2 WP_063857831.1
        pubmed_reference: 19884378 -> 19884378,37255469
    blaCMY-2 WP_000976514.1
        product_name:    class C beta-lactamase CMY-2 -> extended-spectrum class C beta-lactamase CMY-2
        pubmed_reference: 8787910 -> 37255469,8787910
    blaCMY-42 WP_039023136.1
        pubmed_reference: 21388298,27799202 -> 21388298,27799202,37255469
    blaCTX-M-14 WP_001617865.1
        pubmed_reference: 11850241 -> 11850241,37255469
    blaCTX-M-15 WP_000239590.1
        pubmed_reference: 11470367 -> 11470367,37255469
    blaCTX-M-3 WP_011091028.1
        pubmed_reference: 9559791 -> 37255469,9559791
    blaCTX-M-33 WP_032490682.1
        pubmed_reference: 17234386 -> 17234386,37255469
    blaCVI-1 WP_164461288.1
        pubmed_reference: <empty> -> 37513808
    blaDHA-1 WP_004236386.1
        product_name:    class C beta-lactamase DHA-1 -> extended-spectrum class C beta-lactamase DHA-1
        pubmed_reference: 9736562 -> 37255469,9736562
    blaDIM-1 WP_063860203.1
        pubmed_reference: 20308383 -> 20308383,37255469
    blaGES-1 WP_013250881.1
        pubmed_reference: 10681329 -> 10681329,37255469
    blaGES-2 WP_045912044.1
        pubmed_reference: 11502535 -> 11502535,37255469
    blaGES-5 WP_012658785.1
        pubmed_reference: 15135524,19738007 -> 15135524,19738007,37255469
    blaGES-6 WP_032490973.1
        pubmed_reference: 15135524,19738007 -> 15135524,19738007,37255469
    blaGIM-1 WP_015588753.1
        pubmed_reference: 15561840 -> 15561840,37255469
    blaIMI-1 WP_053073497.1
        pubmed_reference: 8878585 -> 37255469,8878585
    blaIMP-1 WP_003159548.1
        pubmed_reference: 8141584 -> 37255469,8141584
    blaKPC-180 WP_290468355.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-180 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-180
    blaKPC-2 WP_004199234.1
        pubmed_reference: 12615876 -> 12615876,37255469
    blaKPC-3 WP_004152396.1
        pubmed_reference: 15561858,19015357 -> 15561858,19015357,37255469
    blaKPC-41 WP_148044419.1
        pubmed_reference: 31527032 -> 31527032,37255469
    blaNDM-1 WP_004201164.1
        pubmed_reference: 19770275 -> 19770275,37255469
    blaNDM-5 WP_023408309.1
        pubmed_reference: 21930874 -> 21930874,37255469
    blaNDM-7 WP_032495622.1
        pubmed_reference: 23557929 -> 23557929,37255469
    blaNDM-9 WP_032495672.1
        pubmed_reference: 24913967,36796395,37394537 -> 24913967,36796395,37255469,37394537
    blaNMC-A WP_050737109.1
        pubmed_reference: 8052644 -> 8052644,37255469
    blaOXA-1 WP_001334766.1
        pubmed_reference: 2823258 -> 2823258,37255469
    blaOXA-1013 WP_219860726.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1047 WP_213384363.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1048 WP_240067728.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1058 WP_242934079.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1059 WP_242934080.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1060 WP_242934081.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1061 WP_242934082.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1062 WP_242934083.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1063 WP_242934084.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1064 WP_242934085.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1065 WP_242934086.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1066 WP_242934087.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1067 WP_242934088.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1068 WP_242934089.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1069 WP_242934090.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1070 WP_242934091.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1071 WP_242934092.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1072 WP_242934093.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1073 WP_242934094.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1074 WP_242934095.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1075 WP_242934096.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1076 WP_215763651.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1077 WP_242934097.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1078 WP_242934098.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1079 WP_242934099.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1080 WP_242934100.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1092 WP_242934106.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1093 WP_242934107.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1094 WP_242934108.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1096 WP_242934110.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1097 WP_242934111.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1098 WP_242934112.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1109 WP_279240791.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1117 WP_249828065.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1118 WP_249828066.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1121 WP_256875611.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1122 WP_256875612.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1123 WP_256875613.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-18 WP_063861237.1
        pubmed_reference: 9333046 -> 9333046,37255469
    blaOXA-181 WP_015060052.1
        pubmed_reference: 21768505 -> 21768505,37255469
    blaOXA-23 WP_001046004.1
        pubmed_reference: 10602749 -> 10602749,37255469
    blaOXA-427 WP_096807440.1
        pubmed_reference: 34427311 -> 34427311,37255469
    blaOXA-48 WP_015059991.1
        pubmed_reference: 14693513 -> 14693513,37255469
    blaOXA-58 WP_002002480.1
        pubmed_reference: 15616297 -> 15616297,37255469
    blaOXA-680 WP_122630864.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-682 WP_122630884.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-683 WP_122630885.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-684 WP_122630886.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-685 WP_122630887.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-686 WP_122630888.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-687 WP_122630889.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-688 WP_122630890.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-689 WP_122630891.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-690 WP_122630892.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-691 WP_122630893.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-692 WP_122630894.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-693 WP_122630895.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-694 WP_122630896.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-695 WP_122630897.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-696 WP_122630898.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-697 WP_122630899.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-698 WP_122630900.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-699 WP_122630901.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-700 WP_122630902.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-701 WP_122630903.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-702 WP_122630904.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-703 WP_122630905.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-704 WP_122630906.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-705 WP_122630907.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-706 WP_122630908.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-707 WP_122630909.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-708 WP_122630916.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-709 WP_122630917.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-710 WP_122630918.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-711 WP_122630919.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-712 WP_122630920.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-713 WP_122630921.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-714 WP_122630922.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-715 WP_016685888.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-716 WP_031998610.1
        subclass:        BETA-LACTAM -> CARBAPENEM
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Changed Hierarchy Nodes
    aac(2')-Ia       aminoglycoside N-acetyltransferase AAC(2')-Ia
        subclass:        GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN
    aac(2')-Ib       aminoglycoside N-acetyltransferase AAC(2')-Ib
        subclass:        GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN
    aac(2')-Ic       aminoglycoside N-acetyltransferase AAC(2')-Ic
        subclass:        GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN
    aac(2')-Id       aminoglycoside N-acetyltransferase AAC(2')-Id
        subclass:        GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN
    aac(2')-Ie       aminoglycoside N-acetyltransferase AAC(2')-Ie
        subclass:        GENTAMICIN/TOBRAMCYIN -> GENTAMICIN/TOBRAMYCIN
    blaOXA-23_fam    OXA-23 family carbapenem-hydrolyzing class D beta-lactamase
        subclass:        BETA-LACTAM -> CARBAPENEM
    cfr              23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr
        class:           PHENICOL/LINCOSAMIDE/OXAZOLIDINONES/PLEUROMUTILIN/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        PHENICOL/CLINDAMYCIN/LINEZOLID/TIAMUTILIN/STREPTOGRAMIN -> PHENICOL/CLINDAMYCIN/LINEZOLID/TIAMULIN/STREPTOGRAMIN
    ere(A)           EreA family erythromycin esterase
        subclass:        MACROLIDE -> ERYTHROMYCIN
    ere(B)           EreB family erythromycin esterase
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    ere(D)           EreD family erythromycin esterase
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    erm(30)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(30)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    erm(31)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(31)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    erm(33)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(33)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN
    erm(34)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(34)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN
    erm(35)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(35)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    erm(36)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(36)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    erm(37)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN
    erm(38)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(38)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN
    erm(39)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(39)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN
    erm(40)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(40)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN
    erm(42)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(42)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    erm(43)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(43)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN
    erm(44)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(44)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN
    erm(44)v         23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(44)v
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    erm(45)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(45)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/PRISTINAMYCIN
    erm(46)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(46)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/VIRGINIAMYCIN
    erm(47)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(47)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN
    erm(48)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(48)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/PRISTINAMYCIN
    erm(49)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(49)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    erm(50)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLARITHROMYCIN/CLINDAMYCIN
    erm(51)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(51)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/VIRGINIAMYCIN
    erm(54)          23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(54)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN
    erm(A)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE
        subclass:        MACROLIDE -> AZITHROMYCIN/CLARITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/TELITHROMYCIN
    erm(B)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(C)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(C)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(D)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(D)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN
    erm(E)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(E)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN
    erm(F)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(F)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/MACROLIDE/STREPTOGRAMIN
    erm(G)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(G)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(H)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(H)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOMYCIN/TYLOSIN/VERNAMYCIN B
    erm(K)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(K)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(N)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(N)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(O)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(O)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOMYCIN/PRISTINAMYCIN/TYLOSIN
    erm(Q)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(Q)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN
    erm(R)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(R)
        subclass:        MACROLIDE -> ERYTHROMYCIN
    erm(S)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(S)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/OSTREOGRYCIN/TYLOSIN
    erm(T)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(T)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(U)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(U)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> LINCOMYCIN/MACROLIDE/STREPTOGRAMIN
    erm(V)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(V)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> CLINDAMYCIN/ERYTHROMYCIN/TYLOSIN/VERNAMYCIN B
    erm(W)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(W)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/LINCOSAMIDE/STREPTOGRAMIN/TYLOSIN
    erm(X)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(X)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/LINCOMYCIN/STREPTOGRAMIN B/TYLOSIN
    erm(Y)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(Y)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/CLINDAMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    erm(Z)           23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(Z)
        class:           MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    estT             macrolide hydrolase EstT
        subclass:        MACROLIDE -> TYLOSIN
    mef(A)           macrolide efflux MFS transporter Mef(A)
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN
    mef(B)           macrolide efflux MFS transporter Mef(B)
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN
    mef(C)           macrolide efflux MFS transporter Mef(C)
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(F)           macrolide efflux MFS transporter Mef(F)
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN
    mgt              macrolide-inactivating glycosyltransferase
        subclass:        MACROLIDE -> ERYTHROMYCIN/TYLOSIN
    mph(A)           Mph(A) family macrolide 2'-phosphotransferase
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    mph(B)           Mph(B) family macrolide 2'-phosphotransferase
        subclass:        MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    mph(C)           Mph(C) family macrolide 2'-phosphotransferase
        subclass:        MACROLIDE -> ERYTHROMYCIN/SPIRAMYCIN/TELITHROMYCIN
    mph(E)           Mph(E) family macrolide 2'-phosphotransferase
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mph(F)           Mph(F) family macrolide 2'-phosphotransferase
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mph(G)           Mph(G) family macrolide 2'-phosphotransferase
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mphH             macrolide 2'-phosphotransferase MphH
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TYLOSIN
    mphK             macrolide 2'-phosphotransferase MphK
        subclass:        MACROLIDE -> TELITHROMYCIN/TYLOSIN
    mphN             macrolide 2'-phosphotransferase MphN
        subclass:        MACROLIDE -> ERYTHROMYCIN
    msr(A)           ABC-F type ribosomal protection protein Msr(A)
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/STREPTOGRAMIN B
    msr(C)           ABC-F type ribosomal protection protein Msr(C)
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B/TYLOSIN
    msr(D)           ABC-F type ribosomal protection protein Msr(D)
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        ERYTHROMYCIN -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN B
    msr(E)           ABC-F type ribosomal protection protein Msr(E)
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/STREPTOGRAMIN
    msr(F)           ABC-F type ribosomal protection protein Msr(F)
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/PRISTINAMYCIN
    msr(G)           ABC-F type ribosomal protection protein Msr(G)
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/PRISTINAMYCIN
    msr(H)           ABC-F type ribosomal protection protein Msr(H)
        class:           MACROLIDE -> MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE -> ERYTHROMYCIN/PRISTINAMYCIN
    myrA             23S rRNA (guanine(748)-N(1))-methyltransferase MyrA
        subclass:        MACROLIDE -> TYLOSIN
    ole(B)           ABC-F type ribosomal protection protein Ole(B)
        subclass:        MACROLIDE -> OLEANDOMYCIN
    oleD             oleandomycin glycosyltransferase OleD
        subclass:        MACROLIDE -> ERYTHROMYCIN/OLEANDOMYCIN/TYLOSIN
    oleI             OleI family self-immunity macrolide glycosyltransferase
        subclass:        MACROLIDE -> OLEANDOMYCIN
    srm(B)           ABC-F type ribosomal protection protein Srm(B)
        subclass:        MACROLIDE -> SPIRAMYCIN
    tlr(C)           ABC-F type ribosomal protection protein Tlr(C)
        subclass:        MACROLIDE -> TYLOSIN
    tva(A)           ABC-F type ribosomal protection protein Tva(A)
        subclass:        PLEUROMUTILIN/STREPTOGRAMIN -> TIAMULIN
    tva(B)           ABC-F type ribosomal protection protein Tva(B)
        subclass:        PLEUROMUTILIN/STREPTOGRAMIN -> TIAMULIN
    vmlR             ABC-F type ribosomal protection protein VmlR
        class:           MACROLIDE/PLEUROMUTILIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/STREPTOGRAMIN/TIAMULIN -> LINCOMYCIN/TIAMULIN/VIRGINIAMYCIN M


----------------------------------------------------------------------
Changes included in 2023-07-13.2
----------------------------------------------------------------------

Overview:

 - Name and subclass changed for blaNDM-9 to highlight that, unlike other NDMs,
   NDM-9 is taniborbactam resistant
 - Changed symbol for AAC74250.1 to ariR to match protein name
 - Review and revision of van genes to standardize nomenclature led to changes
   symbol and name in a number of genes (particularly vanS)
 - Protein name changes toward standardizing the naming of some genes,
   particularly adhesins
 - Curation and addition of recently published stx variants led to new stx
   genes, HMMs, hierarchy nodes, and changes in names for some Stx protein
   sequences
 - Further curation of specific phenotypes based on the literature
 - Several efflux pumps were moved from AMR to BIOCIDE/STRESS to reflect their
   primary activity against benzenes
 - Some new beta-lacatamase families added
 - 13 new point mutations including baeS mutations for Enterobacter_asburiae
   and blaOXA promoter mutations for Acinetobacter_baumannii


Summary:
   Total proteins: 7802
        Core proteins: 6691
        Plus proteins: 1110
   AMR proteins: 6732
   STRESS proteins: 252
   VIRULENCE proteins: 818
   PubMed references: 3516
   Point mutations: 1164
   Point mutation reference sequences: 206
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_asburiae,
       Enterobacter_cloacae, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae, Neisseria_gonorrhoeae,
       Neisseria_meningitidis, Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens,
       Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 719

Updates since release 2023-04-17.1:
   Proteins added: 65
       Core proteins added: 44
       Plus proteins added: 21
   AMR proteins added: 46
   STRESS proteins added: 8
   VIRULENCE proteins added: 11
   Alleles added: 39
   PubMed references added: 88
   Point mutations added: 13
   Proteins removed: 2
       Core proteins removed: 1
       Plus proteins removed: 1
   Reference Gene Catalog entries changed: 179
   Hierarchy nodes added: 21
   Hierarchy nodes changed: 69

Added proteins
    core AMR AMR
        dfrA44           NG_073446.2 WP_031380727.1     trimethoprim-resistant dihydrofolate reductase DfrA44
        estT             NG_203374.1 WP_185148407.1     macrolide hydrolase EstT
        tetB(60)         NG_203376.1 WP_289811733.1     tetracycline efflux ABC transporter Tet(60) subunit B
        tetA(60)         NG_203375.1 WP_289811734.1     tetracycline efflux ABC transporter Tet(60) subunit A
        dfrL             NG_203373.1 WP_290468344.1     trimethoprim-resistant dihydrofolate reductase DfrL
        blaADC-334       NG_203377.1 WP_002052571.1     extended-spectrum class C beta-lactamase ADC-334
        blaADC-335       NG_203378.1 WP_290468345.1     extended-spectrum class C beta-lactamase ADC-335
        blaAMZ-1         NG_203379.1 WP_280147732.1     class C beta-lactamase AMZ-1
        blaBIM-1         NG_203380.1 WP_099592735.1     subclass B1 metallo-beta-lactamase BIM-1
        blaCHM-1         NG_203381.1 WP_202272142.1     subclass B1 metallo-beta-lactamase CHM-1
        blaCMY-186       NG_203383.1 WP_281461078.1     class C beta-lactamase CMY-186
        blaCTX-M-260     NG_157064.1 WP_279383147.1     extended-spectrum class A beta-lactamase CTX-M-260
        blaCTX-M-261     NG_203384.1 WP_242935024.1     extended-spectrum class A beta-lactamase CTX-M-261
        blaCTX-M-262     NG_203385.1 WP_290468346.1     extended-spectrum class A beta-lactamase CTX-M-262
        blaCTX-M-263     NG_203386.1 WP_290468347.1     extended-spectrum class A beta-lactamase CTX-M-263
        blaCTX-M-264     NG_203387.1 WP_290468348.1     extended-spectrum class A beta-lactamase CTX-M-264
        blaCTX-M-265     NG_203388.1 WP_290468349.1     extended-spectrum class A beta-lactamase CTX-M-265
        blaDHA-30        NG_203389.1 WP_283624015.1     class C beta-lactamase DHA-30
        blaGES-59        NG_203390.1 WP_290468350.1     class A beta-lactamase GES-59
        blaIMP-100       NG_203391.1 WP_285798245.1     subclass B1 metallo-beta-lactamase IMP-100
        blaIND-17        NG_203392.1 WP_214824597.1     subclass B1 metallo-beta-lactamase IND-17
        blaKPC-124       NG_203393.1 WP_290468351.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-124
        blaKPC-129       NG_203394.1 WP_290468352.1     class A beta-lactamase KPC-129
        blaKPC-178       NG_203395.1 WP_290468353.1     inhibitor-resistant class A beta-lactamase KPC-178
        blaKPC-179       NG_203396.1 WP_290468354.1     class A beta-lactamase KPC-179
        blaKPC-180       NG_203397.1 WP_290468355.1     carbapenem-hydrolyzing class A beta-lactamase KPC-180
        blaNDM-56        NG_203399.1 WP_280940591.1     subclass B1 metallo-beta-lactamase NDM-56
        blaNDM-57        NG_203400.1 WP_280146998.1     subclass B1 metallo-beta-lactamase NDM-57
        blaNDM-58        NG_203401.1 WP_290468356.1     subclass B1 metallo-beta-lactamase NDM-58
        blaNDM-60        NG_203402.1 WP_290468357.1     subclass B1 metallo-beta-lactamase NDM-60
        blaOXA-1012      NG_203403.1 WP_252655163.1     OXA-48 family class D beta-lactamase OXA-1012
        blaOXA-1200      NG_203404.1 WP_290468358.1     OXA-48 family class D beta-lactamase OXA-1200
        blaOXA-1201      NG_203405.1 WP_290468359.1     OXA-48 family class D beta-lactamase OXA-1201
        blaOXA-1202      NG_203406.1 WP_290468360.1     OXA-10 family class D beta-lactamase OXA-1202
        blaOXA-1203      NG_203407.1 WP_281441144.1     OXA-10 family class D beta-lactamase OXA-1203
        blaOXA-1205      NG_203408.1 WP_290468361.1     OXA-48 family class D beta-lactamase OXA-1205
        blaOXA-1207      NG_203409.1 WP_290468362.1     OXA-48 family class D beta-lactamase OXA-1207
        blaOXA-1208      NG_203410.1 WP_290468363.1     OXA-211 family carbapenem-hydrolyzing class D beta-lactamase OXA-1208
        blaPDC-553       NG_203412.1 WP_290468364.1     class C beta-lactamase PDC-553
        blaPSZ-1         NG_203413.1 WP_290468365.1     class C beta-lactamase PSZ-1
        blaTEM-251       NG_203416.1 WP_222898572.1     class A beta-lactamase TEM-251
        blaVIM-84        NG_203417.1 WP_256823972.1     subclass B1 metallo-beta-lactamase VIM-84
        blaVIM-85        NG_203418.1 WP_260890415.1     subclass B1 metallo-beta-lactamase VIM-85
        mcr-1.35         NG_203419.1 WP_290468366.1     phosphoethanolamine--lipid A transferase MCR-1.35
    plus AMR AMR
        narA             MN590304.1 QHA94808.1          ionophore ABC transporter ATP-binding subunit NarA
        narB             MN590304.1 QHA94809.1          ionophore ABC transporter permease subunit NarB
    plus STRESS METAL
        arsN2            CP000150.1 ABB05616.1          arsenic resistance N-acetyltransferase ArsN2
        arsN2            CP000386.1 ABG05788.1          arsenic resistance N-acetyltransferase ArsN2
        arsN2            CP000804.1 ABU58394.1          arsenic resistance N-acetyltransferase ArsN2
        arsN1            CP009286.1 AIQ64103.1          arsinothricin resistance N-acetyltransferase ArsN1 family A
        arsN2            LDTF01000097.1 KTT96020.1      arsenic resistance N-acetyltransferase ArsN2
        arsN1            LVVJ01000026.1 KYZ65872.1      arsinothricin resistance N-acetyltransferase ArsN1 family A
        arsN1            FORR01000002.1 SFI81893.1      arsinothricin resistance N-acetyltransferase ArsN1 family A
        arsN2            CP090098.1 UIK15784.1          arsenic resistance N-acetyltransferase ArsN2
    plus VIRULENCE VIRULENCE
        stxA2k           KC339670.2 AGB13719.2          Shiga toxin Stx2k subunit A
        stxB1e           KF926684.1 AHJ80154.1          Shiga toxin Stx1e subunit B
        stxA1e           KF926684.1 AHJ80155.1          Shiga toxin Stx1e subunit A
        peg-344          AP006726.1 BAH65947.1          DMT family inner membrane transporter PEG344
        stxB2j           RUOX02000009.1 EED0303793.1    Shiga toxin Stx2j subunit B
        stxA2o           AARLAS010000016.1 EEV0948227.1 Shiga toxin Stx2o subunit A
        stxB2o           AARLAS010000016.1 EEV0948228.1 Shiga toxin Stx2o subunit B
        stxB2k           CP041435.1 QHR28666.1          Shiga toxin Stx2k subunit B
        stxA2k           CP041435.1 QHR28667.1          Shiga toxin Stx2k subunit A
        stxB2n           CP113092.1 WAK53219.1          Shiga toxin Stx2n subunit B
        stxB2m           OQ054797.1 WGO76392.1          Shiga toxin Stx2m subunit B
Added point mutations
    core AMR POINT
        baeS_T175P       AZTREONAM/TEMOCILLIN/TICARCILLIN Enterobacter_cloacae
        baeS_T175P       AZTREONAM/TEMOCILLIN/TICARCILLIN Enterobacter_asburiae
        blaOXA_A-14G     CARBAPENEM Acinetobacter_baumannii
        blaOXA_G-42A     CARBAPENEM Acinetobacter_baumannii
        rpoB_D471E       RIFAMPIN Staphylococcus_aureus
        rpoB_D516G       RIFAMPIN Escherichia
        rpoB_H526L       RIFAMPIN Escherichia
        rpoB_L511Q       RIFAMPIN Escherichia
        rpoB_N474L       RIFAMPIN Staphylococcus_aureus
        rpoB_Q148L       RIFAMPIN Escherichia
        rpoB_S583L       RIFAMPIN Acinetobacter_baumannii
        rpoB_V1143D      FIDAXOMICIN Clostridioides_difficile
        rpoB_V1143G      FIDAXOMICIN Clostridioides_difficile
Removed proteins
    core AMR AMR
        dfrA44           NG_073446.1 WP_204376220.1     trimethoprim-resistant dihydrofolate reductase DfrA44
    plus VIRULENCE VIRULENCE
        stxB2d           DQ059012.1 AAY63865.1          Shiga toxin Stx2d subunit B
Changed reference gene catalog records
    cph AAA92037.1
        pubmed_reference: <empty> -> 34994196
    ttgB AAC38671.1
        pubmed_reference: <empty> -> 14506010
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    ariR AAC74250.1
        gene_family:     ymgB -> ariR
    srpB AAD12176.1
        pubmed_reference: <empty> -> 9417051
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    ttgI AAD12177.1
        pubmed_reference: <empty> -> 11395460
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    srpA AAD12178.1
        pubmed_reference: <empty> -> 9417051
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    tbtA AAD15663.1
        pubmed_reference: <empty> -> 15019728
    tbtB AAD15664.1
        pubmed_reference: <empty> -> 15019728
    tbtM AAD15665.1
        pubmed_reference: <empty> -> 15019728
    ttgA AAD39553.1
        pubmed_reference: <empty> -> 14506010
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    mtrA AAD44693.1
        pubmed_reference: <empty> -> 23221802
    farB AAD54074.1
        pubmed_reference: <empty> -> 10447892
    mdsB AAL19305.1
        pubmed_reference: <empty> -> 24960027,26283336
    mdsA AAL19306.1
        pubmed_reference: <empty> -> 24960027,26283336
    bepD AAN29240.1
        pubmed_reference: <empty> -> 19201794
    bepE AAN29241.1
        pubmed_reference: <empty> -> 19201794
    bepC AAN29871.1
        pubmed_reference: <empty> -> 19201794
    bepG AAN33534.1
        pubmed_reference: <empty> -> 19201794
    bepF AAN33535.1
        pubmed_reference: <empty> -> 19201794
    adeE AAN38824.2
        pubmed_reference: <empty> -> 15388479,30311872
    sdeB AAO18187.2
        pubmed_reference: <empty> -> 15793131
    ttgD AAO49780.1
        pubmed_reference: <empty> -> 11251828
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    emhC AAQ92182.1
        pubmed_reference: <empty> -> 14563857
    adeD AAU10477.1
        pubmed_reference: <empty> -> 15388479
    mepA AAU95768.1
        class:           EFFLUX -> TETRACYCLINE
        pubmed_reference: <empty> -> 15855508
        subclass:        EFFLUX -> TIGECYCLINE
    emhA AAY90617.2
        pubmed_reference: <empty> -> 14563857
    fdeC ABE05822.1
        product_name:    intimin-like adhesin FdeC -> inverse autotransporter adhesin FdeC
    emrD3 ABQ18953.1
        pubmed_reference: <empty> -> 19876617
    kdeA ABR76310.1
        pubmed_reference: <empty> -> 17917272
    mtrR ACF30254.1
        pubmed_reference: <empty> -> 23221802
    emhB ACO06752.1
        pubmed_reference: <empty> -> 14563857
    amvA ACQ82816.1
        pubmed_reference: <empty> -> 20573661
    ttgE ADI95409.1
        pubmed_reference: <empty> -> 26363557
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    ranA ADZ12699.1
        class:           <empty> -> EFFLUX
        subclass:        <empty> -> EFFLUX
    ranB ADZ12700.1
        class:           <empty> -> EFFLUX
        subclass:        <empty> -> EFFLUX
    vanR-Cd AXB64454.1
        product_name:    vancomycin resistance response regulator transcriptoin factor VanR-G-Cd -> vancomycin resistance response regulator transcription factor VanR-G-Cd
    mepA BAB41547.1
        class:           EFFLUX -> TETRACYCLINE
        pubmed_reference: <empty> -> 15855508
        subclass:        EFFLUX -> TIGECYCLINE
    cofA BAB62897.1
        product_name:    type IV pilus CFA/III major pilin -> type 4b pilus CFA/III major pilin CofA
    stxA1a BAC10987.1
        gene_family:     stxA1c -> stxA1a
        hierarchy_node:  stxA1c -> stxA1a
        product_name:    Shiga toxin Stx1c subunit A -> Shiga toxin Stx1a subunit A
        subclass:        STX1C -> STX1A
    stxB1a BAC10988.1
        gene_family:     stxB1c -> stxB1a
        hierarchy_node:  stxB1c -> stxB1a
        product_name:    Shiga toxin Stx1c subunit B -> Shiga toxin Stx1a subunit B
        subclass:        STX1C -> STX1A
    sdeY BAC77251.1
        pubmed_reference: <empty> -> 12837741
    emrD BAE77620.1
        pubmed_reference: <empty> -> 16675700
    smfY BAE79899.1
        pubmed_reference: <empty> -> 17409524
    ttgA BAF76383.1
        pubmed_reference: <empty> -> 14506010
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    ttgB BAF76384.1
        pubmed_reference: <empty> -> 14506010
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    smeF CAC14596.1
        class:           EFFLUX -> QUINOLONE
        pubmed_reference: <empty> -> 24837376
        subclass:        EFFLUX -> QUINOLONE
    vanZ1 CAJ68095.1
        pubmed_reference: <empty> -> 29940245
    emrC CAQ45062.1
        pubmed_reference: <empty> -> 23794602
    emrA CAQ45063.1
        pubmed_reference: <empty> -> 23794602
    emrB CAQ45064.1
        pubmed_reference: <empty> -> 23794602
    helR CCA59315.1
        pubmed_reference: <empty> -> 34964291
    inv CCV30618.1
        product_name:    autotransporter invasin Inv -> inverse autotransporter invasin Inv
    emrC EAC4468893.1
        pubmed_reference: <empty> -> 27998823
    catC KGT34314.1
        product_name:    type B chloramphenicol O-acetyltransferase -> type C chloramphenicol O-acetyltransferase
        pubmed_reference: <empty> -> 30878668,31762145
    aph(3')-IId QQK39289.1
        pubmed_reference: <empty> -> 34329431
    ant(2'')-Ia WP_000381803.1
        synonyms:        <empty> -> aadB
    vanS-A WP_002305818.1
        product_name:    VanA-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-A
    vanS-B WP_002368696.1
        product_name:    VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B
    vanS-B WP_002382867.1
        product_name:    VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B
    ant(2'')-Ia WP_003159209.1
        synonyms:        <empty> -> aadB
    vanS-Sc WP_003975349.1
        product_name:    VanSc-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Sc
    vanR-F WP_006285581.1
        product_name:    VanF-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-F
    vanS-F WP_006285582.1
        product_name:    VanF-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-F
    tet(X2) WP_008651082.1
        pubmed_reference: 33287863 -> 32938927,33287863,37141282
        subclass:        TETRACYCLINE -> TIGECYCLINE
    vanS-I WP_011461302.1
        product_name:    VanI-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-I
    vanS-B WP_012579101.1
        product_name:    VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B
    tet(X2) WP_015060600.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    vanS-G WP_021418927.1
        product_name:    VanG-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-G
    vanS-D WP_023042297.1
        product_name:    VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D
    vanS-D WP_028530133.1
        product_name:    VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D
    vanC1 WP_029487031.1
        gene_family:     vanC -> vanC1
    crpP WP_033179079.1
        product_name:    ciprofloxacin resistance protein CrpP -> ICE-associated protein CrpP
    vanS-C WP_034869172.1
        product_name:    VanC-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-C
    vanC1 WP_040013725.1
        gene_family:     vanC -> vanC1
    ant(2'')-Ia WP_042852798.1
        synonyms:        <empty> -> aadB
    aac(6')-Ia WP_058677876.1
        synonyms:        <empty> -> aacA1
    tet(X2) WP_063856436.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    vanC1 WP_063856645.1
        gene_family:     vanC -> vanC1
    vanC1 WP_063856686.1
        gene_family:     vanC -> vanC1
    vanC1 WP_063856687.1
        gene_family:     vanC -> vanC1
    vanC1 WP_063856688.1
        gene_family:     vanC -> vanC1
    vanR-M WP_063856726.1
        product_name:    VanM-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-M
    vanS-D WP_063856730.1
        product_name:    VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D
    vanS-A WP_063856731.1
        product_name:    VanA-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-A
    vanS-G WP_063856732.1
        product_name:    VanG-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-G
    vanS-C WP_063856733.1
        product_name:    VanC-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-C
    vanS-E WP_063856734.1
        product_name:    VanE-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-E
    vanS-D WP_063856738.1
        product_name:    VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D
    vanS-B WP_063856739.1
        product_name:    VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B
    vanS-Pt2 WP_063856740.1
        product_name:    VanPt2-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Pt2
    vanS-Pt WP_063856741.1
        product_name:    VanPt-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Pt
    vanS-Pt WP_063856742.1
        product_name:    VanPt-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Pt
    vanS-C WP_063856743.1
        product_name:    VanC-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-C
    vanS-D WP_063856744.1
        product_name:    VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D
    vanS-L WP_063856745.1
        product_name:    VanL-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-L
    vanS-M WP_063856748.1
        product_name:    VanM-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-M
    vanS-N WP_063856749.1
        product_name:    VanN-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-N
    vanS-B WP_063856751.1
        product_name:    VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B
    vanS-O WP_070064533.1
        product_name:    VanO-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-O
    dfrA1 WP_071846186.1
        synonyms:        <empty> -> dfr1
    ant(2'')-Ia WP_071846217.1
        synonyms:        <empty> -> aadB
    ant(2'')-Ia WP_071846230.1
        synonyms:        <empty> -> aadB
    ant(2'')-Ia WP_071846238.1
        synonyms:        <empty> -> aadB
    dfrA1 WP_071846293.1
        synonyms:        <empty> -> dfr1
    dfrA1 WP_071846295.1
        synonyms:        <empty> -> dfr1
    ant(2'')-Ia WP_071846303.1
        synonyms:        <empty> -> aadB
    ant(2'')-Ia WP_071846305.1
        synonyms:        <empty> -> aadB
    dfrA1 WP_071846306.1
        synonyms:        <empty> -> dfr1
    ant(2'')-Ia WP_071846312.1
        synonyms:        <empty> -> aadB
    ant(2'')-Ia WP_071846313.1
        synonyms:        <empty> -> aadB
    ant(2'')-Ia WP_071846314.1
        synonyms:        <empty> -> aadB
    ant(2'')-Ia WP_071846317.1
        synonyms:        <empty> -> aadB
    aac(6')-Il WP_071846318.1
        synonyms:        <empty> -> aacA7
    ant(2'')-Ia WP_071846341.1
        synonyms:        <empty> -> aadB
    ant(2'')-Ia WP_071846360.1
        synonyms:        <empty> -> aadB
    dfrA1 WP_071846366.1
        synonyms:        <empty> -> dfr1
    ant(2'')-Ia WP_071846368.1
        synonyms:        <empty> -> aadB
    dfrA1 WP_071846387.1
        synonyms:        <empty> -> dfr1
    rphC WP_087347987.1
        pubmed_reference: <empty> -> 24778229,29259290
    rphD WP_087348261.1
        pubmed_reference: <empty> -> 24778229,29259290
    dfrA1 WP_140423283.1
        synonyms:        <empty> -> dfr1
    vanS-P WP_222891058.1
        product_name:    VanP-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-P
    blaCMH-9 WP_058650678.1
        genbank_nucleotide_accession: ABFHGH010000056.1 -> ABFHGH020000056.1
        genbank_protein_accession: EIY2541268.1 -> EKU2771784.1
    blaIND-19 WP_274375789.1
        allele:          blaIND-17 -> blaIND-19
        hierarchy_node:  blaIND-17 -> blaIND-19
        product_name:    subclass B1 metallo-beta-lactamase IND-17 -> subclass B1 metallo-beta-lactamase IND-19
    blaKPC-44 WP_140423311.1
        product_name:    inhibitor-resistant extended-spectrum class A beta-lactamase KPC-44 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-44
        subclass:        CEPHALOSPORIN -> CARBAPENEM
    blaKPC-62 WP_204376229.1
        pubmed_reference: 33775814 -> 33775814,36964710
    blaMOX-18 WP_268871858.1
        product_name:    class C beta-lactamase MOX-18 -> CMY-1/MOX family class C beta-lactamase MOX-18
    blaMOX-19 WP_268871859.1
        product_name:    class C beta-lactamase MOX-19 -> CMY-1/MOX family class C beta-lactamase MOX-19
    blaMOX-20 WP_268871860.1
        product_name:    class C beta-lactamase MOX-20 -> CMY-1/MOX family class C beta-lactamase MOX-20
    blaMOX-21 WP_268871861.1
        product_name:    class C beta-lactamase MOX-21 -> CMY-1/MOX family class C beta-lactamase MOX-21
    blaMOX-22 WP_223915751.1
        product_name:    class C beta-lactamase MOX-22 -> CMY-1/MOX family class C beta-lactamase MOX-22
    blaMOX-23 WP_180898621.1
        product_name:    class C beta-lactamase MOX-23 -> CMY-1/MOX family class C beta-lactamase MOX-23
    blaMOX-24 WP_244054059.1
        product_name:    class C beta-lactamase MOX-24 -> CMY-1/MOX family class C beta-lactamase MOX-24
    blaMOX-25 WP_128343957.1
        product_name:    class C beta-lactamase MOX-25 -> CMY-1/MOX family class C beta-lactamase MOX-25
    blaNDM-50 WP_274293087.1
        genbank_nucleotide_accession: ABJWWM010000052.1 -> ABJWWM020000052.1
        genbank_protein_accession: EKH0703529.1 -> EKV8557274.1
    blaNDM-9 WP_032495672.1
        product_name:    subclass B1 metallo-beta-lactamase NDM-9 -> taniborbactam-resistant subclass B1 metallo-beta-lactamase NDM-9
        pubmed_reference: 24913967 -> 24913967,36796395,37394537
        subclass:        CARBAPENEM -> CARBAPENEM/TANIBORBACTAM
    blaOXA-1038 WP_231869643.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-1039 WP_037414505.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-1055 WP_240067733.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-1091 WP_012045014.1
        product_name:    class D beta-lactamase OXA-1091 -> oxacillin-hydrolyzing class D beta-lactamase OXA-1091
    blaOXA-1119 WP_256875609.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-1146 WP_262697143.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-1181 WP_274293088.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-519 WP_094009808.1
        product_name:    OXA-48 family class D beta-lactamase OXA-519 -> OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-519
    blaOXA-538 WP_071593227.1
        product_name:    OXA-48 family class D beta-lactamase OXA-538 -> OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-538
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-546 WP_087587945.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-566 WP_094009811.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-567 WP_099156052.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-793 WP_136512085.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-833 WP_140423324.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-918 WP_179284333.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-920 WP_179284336.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-922 WP_188331876.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-923 WP_179284342.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-924 WP_179284345.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-929 WP_188331878.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-933 WP_231869591.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-934 WP_231869592.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-955 WP_213994600.1
        genbank_nucleotide_accession: AAYMEH010000029.1 -> AAYMEH020000029.1
        genbank_protein_accession: EGY4117187.1 -> EKY1045811.1
    blaRATA-2 WP_154469535.1
        genbank_nucleotide_accession: QXQJ01000019.1 -> CP121210.1
        genbank_protein_accession: MSN81448.1 -> WFS32678.1
        genbank_start:   51 -> 1997285
        genbank_stop:    965 -> 1998199
        refseq_nucleotide_accession: NG_149672.1 -> NG_149672.2
        refseq_start:    51 -> 101
        refseq_stop:     965 -> 1015
    blaSGM-5 WP_007708339.1
        genbank_nucleotide_accession: AJVL01000026.1 -> CP124576.1
        genbank_protein_accession: EJK84395.1 -> WHO40873.1
        genbank_start:   37096 -> 2019317
        genbank_stop:    38076 -> 2020297
        genbank_strand:  - -> +
    blaSHV-27 WP_023282555.1
        subclass:        CEPHALOSPORIN -> BETA-LACTAM
    blaSHV-40 WP_063864681.1
        subclass:        CEPHALOSPORIN -> BETA-LACTAM
    blaSHV-41 WP_063864682.1
        subclass:        CEPHALOSPORIN -> BETA-LACTAM
    blaSHV-42 WP_063864683.1
        subclass:        CEPHALOSPORIN -> BETA-LACTAM
    rpoB_A477D WP_000918664.1
        pubmed_reference: <empty> -> 12384339
    rpoB_A477V WP_000918664.1
        pubmed_reference: <empty> -> 12384339
    rpoB_D471G WP_000918664.1
        pubmed_reference: <empty> -> 12384339
    rpoB_D471Y WP_000918664.1
        pubmed_reference: <empty> -> 12384339
    rpoB_H481N WP_000918664.1
        pubmed_reference: <empty> -> 12384339
    rpoB_H481Y WP_000918664.1
        pubmed_reference: <empty> -> 12384339
    rpoB_I527F WP_000918664.1
        pubmed_reference: <empty> -> 12384339
    rpoB_I572L WP_000263098.1
        pubmed_reference: <empty> -> 11102350
    rpoB_P564L WP_000263098.1
        pubmed_reference: <empty> -> 11102350
    rpoB_Q468L WP_000918664.1
        pubmed_reference: <empty> -> 12384339
    rpoB_Q468R WP_000918664.1
        pubmed_reference: <empty> -> 12384339
    rpoB_R484H WP_000918664.1
        pubmed_reference: <empty> -> 12384339
    rpoB_S464P WP_000918664.1
        pubmed_reference: <empty> -> 12384339
    rpoB_S486L WP_000918664.1
        pubmed_reference: <empty> -> 12384339

Hierarchy nodes added
    core AMR AMR
        blaAMZ           blaAMZ NF041741.1              AMZ family class C beta-lactamase
        blaBIM           blaBIM NF041846.1              BIM family subclass B1 metallo-beta-lactamase
        blaCHM           blaCHM NF041758.1              CHM family subclass B1 metallo-beta-lactamase
        blaPSZ           blaPSZ NF041665.1              PSZ family class C beta-lactamase
        dfrL             dfrL NF041668.1                trimethoprim-resistant dihydrofolate reductase DfrL
        estT             estT NF041759.1                macrolide hydrolase EstT
    non-reported AMR AMR
        IONOPHORE
    plus AMR AMR
        narA             narA                           ionophore ABC transporter ATP-binding subunit NarA
        narB             narB                           ionophore ABC transporter permease subunit NarB
    plus VIRULENCE VIRULENCE
        peg-344          peg-344                        DMT family inner membrane transporter PEG344
        stxA1e           stxA1e NF041696.1              Shiga toxin Stx1e subunit A
        stxA2_acd        stxA2 NF041702.1               Shiga toxin Stx2 subunit A, a/c/d subtype
        stxA2_eilk       stxA2 NF041703.1               Shiga toxin Stx2 subunit A, e/i/l/k subtype
        stxA2k           stxA2k                         Shiga toxin Stx2k subunit A
        stxA2o           stxA2o                         Shiga toxin Stx2o subunit A
        stxB1e           stxB1e NF041700.1              Shiga toxin Stx1e subunit B
        stxB2j           stxB2j                         Shiga toxin Stx2j subunit B
        stxB2k           stxB2k                         Shiga toxin Stx2k subunit B
        stxB2m           stxB2m                         Shiga toxin Stx2m subunit B
        stxB2n           stxB2n                         Shiga toxin Stx2n subunit B
        stxB2o           stxB2o NF041701.1              Shiga toxin Stx2o subunit B
Changed Hierarchy Nodes
    ampC_Ecan        CMY2-MIR-ACT-EC family cephalosporin-hydrolyzing class C beta-lactamase
        hmm_acc:         <empty> -> NF041666.1
    ariR             biofilm/acid-resistance regulator AriR
        symbol:          ymgB -> ariR
    blaL2            L2 family extended-spectrum class A beta-lactamase
        hmm_acc:         NF000232.1 -> <empty>
    blaOXA-1036_fam  OXA-1036 family carbapenem-hydrolyzing class D beta-lactamase
        name:            OXA-1036 family class D beta-lactamase -> OXA-1036 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA-1091_fam  OXA-1091 family oxacillin-hydrolyzing class D beta-lactamase
        name:            OXA-1091 family class D beta-lactamase -> OXA-1091 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA-9_fam     OXA-9 family oxacillin-hydrolyzing class D beta-lactamase
        name:            OXA-9 family class D beta-lactamase -> OXA-9 family oxacillin-hydrolyzing class D beta-lactamase
    blaSPR           SPR family subclass B3 metallo-beta-lactamase
        hmm_acc:         <empty> -> NF041137.1
    blaTLA           TLA family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    catC             type C chloramphenicol O-acetyltransferase
        name:            type B chloramphenicol O-acetyltransferase -> type C chloramphenicol O-acetyltransferase
    cofA             type 4b pilus CFA/III major pilin CofA
        name:            type IV pilus CFA/III major pilin -> type 4b pilus CFA/III major pilin CofA
    crpP             ICE-associated protein CrpP
        name:            ciprofloxacin resistance protein CrpP -> ICE-associated protein CrpP
    dfr_gen          trimethoprim-resistant dihydrofolate reductase
        symbol:          dfrA -> dfr
    fdeC             inverse autotransporter adhesin FdeC
        name:            intimin-like adhesin FdeC -> inverse autotransporter adhesin FdeC
    fosBx1-fam       FosBx1 family fosfomycin resistance bacillithiol transferase
        hmm_acc:         <empty> -> NF041541.1
    fosXCC           fosfomycin resistance hydrolase FosXCC
        hmm_acc:         <empty> -> NF041542.1
    inv              inverse autotransporter invasin Inv
        name:            autotransporter invasin Inv -> inverse autotransporter invasin Inv
    mepA             multidrug efflux MATE transporter MepA
        class:           EFFLUX -> TETRACYCLINE
        subclass:        EFFLUX -> TIGECYCLINE
    ranA             multidrug efflux ABC transporter ATP-binding subunit RanA
        class:           <empty> -> EFFLUX
        subclass:        <empty> -> EFFLUX
    ranB             multidrug efflux ABC transporter permease subunit RanB
        class:           <empty> -> EFFLUX
        subclass:        <empty> -> EFFLUX
    rph_gen          rifamycin-inactivating phosphotransferase
        scope:           core -> non-reported
    smeF             multidrug efflux RND transporter outer membrane subunit SmeF
        class:           EFFLUX -> QUINOLONE
        subclass:        EFFLUX -> QUINOLONE
    srpA             solvent efflux RND transporter periplasmic adaptor subunit SrpA
        parent_node_id:  RND-peri -> BIOCIDE
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    srpB             solvent efflux RND transporter permease subunit SrpB
        parent_node_id:  RND-IM -> BIOCIDE
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    srpC             solvent efflux RND transporter outer membrane subunit SrpC
        parent_node_id:  RND-OM -> BIOCIDE
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    stxA1a           Shiga toxin Stx1a subunit A
        hmm_acc:         <empty> -> NF041694.1
    stxA1c           Shiga toxin Stx1c subunit A
        hmm_acc:         <empty> -> NF041693.1
    stxA1d           Shiga toxin Stx1d subunit A
        hmm_acc:         <empty> -> NF041695.1
    stxA2a           Shiga toxin Stx2a subunit A
        parent_node_id:  stxA2 -> stxA2_acd
    stxA2b           Shiga toxin Stx2b subunit A
        hmm_acc:         <empty> -> NF041688.1
    stxA2c           Shiga toxin Stx2c subunit A
        parent_node_id:  stxA2 -> stxA2_acd
    stxA2d           Shiga toxin Stx2d subunit A
        parent_node_id:  stxA2 -> stxA2_acd
    stxA2e           Shiga toxin Stx2e subunit A
        parent_node_id:  stxA2 -> stxA2_eilk
    stxA2f           Shiga toxin Stx2f subunit A
        hmm_acc:         <empty> -> NF041687.1
    stxA2g           Shiga toxin Stx2g subunit A
        hmm_acc:         <empty> -> NF041690.1
    stxA2i           Shiga toxin Stx2i subunit A
        parent_node_id:  stxA2 -> stxA2_eilk
    stxA2j           Shiga toxin Stx2j subunit A
        hmm_acc:         <empty> -> NF041689.1
    stxA2l           Shiga toxin Stx2l subunit A
        parent_node_id:  stxA2 -> stxA2_eilk
    stxB1a           Shiga toxin Stx1a subunit B
        hmm_acc:         <empty> -> NF041697.1
    stxB1c           Shiga toxin Stx1c subunit B
        hmm_acc:         <empty> -> NF041698.1
    stxB1d           Shiga toxin Stx1d subunit B
        hmm_acc:         <empty> -> NF041699.1
    stxB2b           Shiga toxin Stx2b subunit B
        hmm_acc:         <empty> -> NF041691.1
    stxB2e           Shiga toxin Stx2e subunit B
        hmm_acc:         <empty> -> NF041704.1
    stxB2f           Shiga toxin Stx2f subunit B
        hmm_acc:         <empty> -> NF041692.1
    tet(X2)          tetracycline-inactivating monooxygenase Tet(X2)
        subclass:        TETRACYCLINE -> TIGECYCLINE
    ttgA             toluene efflux RND transporter periplasmic adaptor subunit TtgA
        parent_node_id:  RND-peri -> BIOCIDE
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    ttgB             multidrug efflux RND transporter permease subunit TtgB
        parent_node_id:  RND-IM -> BIOCIDE
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    ttgD             toluene efflux RND transporter periplasmic adaptor subunit TtgD
        parent_node_id:  RND-peri -> BIOCIDE
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    ttgE             multidrug efflux RND transporter permease subunit TtgE
        parent_node_id:  RND-IM -> BIOCIDE
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    vanC1            D-alanine--D-serine ligase VanC1
        symbol:          vanC -> vanC1
    vanR-Cd          vancomycin resistance response regulator transcription factor VanR-G-Cd
        name:            vancomycin resistance response regulator transcriptoin factor VanR-G-Cd -> vancomycin resistance response regulator transcription factor VanR-G-Cd
    vanR-F           vancomycin resistance response regulator transcription factor VanR-F
        name:            VanF-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-F
    vanR-FM          vancomycin resistance response regulator transcription factor, VanR-F/VanR-M family
        name:            vancomycin resistance response regulator transcription factor VanR-FM -> vancomycin resistance response regulator transcription factor, VanR-F/VanR-M family
    vanR-M           vancomycin resistance response regulator transcription factor VanR-M
        name:            VanM-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-M
    vanS-A           vancomycin resistance histidine kinase VanS-A
        name:            VanA-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-A
    vanS-B           vancomycin resistance histidine kinase VanS-B
        name:            VanB-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-B
    vanS-C           vancomycin resistance histidine kinase VanS-C
        name:            VanC-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-C
    vanS-D           vancomycin resistance histidine kinase VanS-D
        name:            VanD-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-D
    vanS-E           vancomycin resistance histidine kinase VanS-E
        name:            VanE-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-E
    vanS-F           vancomycin resistance histidine kinase VanS-F
        name:            VanF-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-F
    vanS-G           vancomycin resistance histidine kinase VanS-G
        name:            VanG-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-G
    vanS-I           vancomycin resistance histidine kinase VanS-I
        name:            VanI-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-I
    vanS-L           vancomycin resistance histidine kinase VanS-L
        name:            VanL-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-L
    vanS-M           vancomycin resistance histidine kinase VanS-M
        name:            VanM-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-M
    vanS-N           vancomycin resistance histidine kinase VanS-N
        name:            VanN-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-N
    vanS-O           vancomycin resistance histidine kinase VanS-O
        name:            VanO-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-O
    vanS-P           vancomycin resistance histidine kinase VanS-P
        name:            VanP-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-P
    vanS-Pt          vancomycin resistance histidine kinase VanS-Pt
        name:            VanPt-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Pt
    vanS-Pt2         vancomycin resistance histidine kinase VanS-Pt2
        name:            VanPt2-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Pt2
    vanS-Sc          vancomycin resistance histidine kinase VanS-Sc
        name:            VanSc-type vancomycin resistance histidine kinase VanS -> vancomycin resistance histidine kinase VanS-Sc


----------------------------------------------------------------------
Changes included in 2023-04-17.1
----------------------------------------------------------------------

Overview:

- We reviewed and refined phenotype information in product name for 57 blaPDC
  alleles (inhibitor-resistant and/or extended-spectrum)
- New refined subclasses for some blaOXA and blaKPC alleles, and the blaOXA-427
  family
- Added phenotype information in the subclass field for some unnamed ampC genes
- four new HMMs
- added 112 new beta-lactamase alleles
- Point mutation detection expanded to include resistance mutations in
  Citrobacter_freundii, Enterobacter_cloacae, Klebsiella_aerogenes, and
  Serratia_marcescens
- 121 new point mutations for Pseudomonas_aeruginosa

Summary:
   Total proteins: 7739
        Core proteins: 6648
        Plus proteins: 1090
   AMR proteins: 6696
   STRESS proteins: 235
   VIRULENCE proteins: 808
   PubMed references: 3428
   Point mutations: 1151
   Point mutation reference sequences: 202
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Citrobacter_freundii, Clostridioides_difficile, Enterobacter_cloacae,
       Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella_oxytoca,
       Klebsiella_pneumoniae, Neisseria_gonorrhoeae, Neisseria_meningitidis,
       Pseudomonas_aeruginosa, Salmonella, Serratia_marcescens, Staphylococcus_aureus,
       Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae,
       Streptococcus_pyogenes
   HMMs: 692

Updates since release 2023-02-23.1:
   Proteins added: 112
       Core proteins added: 112
       Plus proteins added: 0
   AMR proteins added: 112
   Alleles added: 112
   PubMed references added: 516
   Point mutations added: 138
   Reference Gene Catalog entries changed: 367
   Hierarchy nodes added: 4
   Hierarchy nodes changed: 2
   HMMs added: 4

Added proteins
    core AMR AMR
        blaACT-112       NG_156952.1 WP_134179367.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-112
        blaACT-113       NG_156953.1 WP_279240765.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-113
        blaACT-114       NG_156954.1 WP_180255442.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-114
        blaACT-115       NG_156955.1 WP_058652386.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-115
        blaACT-116       NG_156956.1 WP_073000989.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-116
        blaACT-117       NG_156957.1 WP_279240766.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-117
        blaACT-118       NG_156958.1 WP_279240767.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-118
        blaACT-119       NG_156959.1 WP_279240768.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-119
        blaADC-292       NG_156960.1 WP_274858813.1     extended-spectrum class C beta-lactamase ADC-292
        blaADC-293       NG_156961.1 WP_279240769.1     extended-spectrum class C beta-lactamase ADC-293
        blaADC-294       NG_156962.1 WP_279240770.1     extended-spectrum class C beta-lactamase ADC-294
        blaADC-295       NG_156963.1 WP_009389984.1     extended-spectrum class C beta-lactamase ADC-295
        blaADC-302       NG_156964.1 WP_001211202.1     extended-spectrum class C beta-lactamase ADC-302
        blaADC-303       NG_156965.1 WP_001211225.1     extended-spectrum class C beta-lactamase ADC-303
        blaADC-304       NG_156966.1 WP_272307067.1     extended-spectrum class C beta-lactamase ADC-304
        blaADC-305       NG_156967.1 WP_272267218.1     extended-spectrum class C beta-lactamase ADC-305
        blaADC-306       NG_156968.1 WP_272372047.1     extended-spectrum class C beta-lactamase ADC-306
        blaADC-307       NG_156969.1 WP_272247217.1     extended-spectrum class C beta-lactamase ADC-307
        blaADC-308       NG_156970.1 WP_065712098.1     extended-spectrum class C beta-lactamase ADC-308
        blaADC-309       NG_156971.1 WP_272326044.1     extended-spectrum class C beta-lactamase ADC-309
        blaADC-310       NG_156972.1 WP_032029974.1     extended-spectrum class C beta-lactamase ADC-310
        blaADC-311       NG_156973.1 WP_174749605.1     extended-spectrum class C beta-lactamase ADC-311
        blaADC-312       NG_156974.1 WP_261470340.1     extended-spectrum class C beta-lactamase ADC-312
        blaADC-313       NG_156975.1 WP_272333251.1     extended-spectrum class C beta-lactamase ADC-313
        blaADC-314       NG_156976.1 WP_272290549.1     extended-spectrum class C beta-lactamase ADC-314
        blaADC-315       NG_156977.1 WP_031380135.1     extended-spectrum class C beta-lactamase ADC-315
        blaADC-316       NG_156978.1 WP_272273772.1     extended-spectrum class C beta-lactamase ADC-316
        blaADC-317       NG_156979.1 WP_272389475.1     extended-spectrum class C beta-lactamase ADC-317
        blaADC-318       NG_156980.1 WP_272311194.1     extended-spectrum class C beta-lactamase ADC-318
        blaADC-319       NG_156981.1 WP_272284684.1     extended-spectrum class C beta-lactamase ADC-319
        blaADC-320       NG_156982.1 WP_272236549.1     extended-spectrum class C beta-lactamase ADC-320
        blaADC-321       NG_156983.1 WP_262093836.1     extended-spectrum class C beta-lactamase ADC-321
        blaADC-322       NG_156984.1 WP_272291658.1     extended-spectrum class C beta-lactamase ADC-322
        blaADC-323       NG_156985.1 WP_272359117.1     extended-spectrum class C beta-lactamase ADC-323
        blaADC-324       NG_156986.1 WP_272276659.1     extended-spectrum class C beta-lactamase ADC-324
        blaADC-325       NG_156987.1 WP_261479309.1     extended-spectrum class C beta-lactamase ADC-325
        blaADC-326       NG_156988.1 WP_272315880.1     extended-spectrum class C beta-lactamase ADC-326
        blaADC-327       NG_156989.1 WP_272291558.1     extended-spectrum class C beta-lactamase ADC-327
        blaADC-328       NG_156990.1 WP_069370341.1     extended-spectrum class C beta-lactamase ADC-328
        blaADC-329       NG_156991.1 WP_272312953.1     extended-spectrum class C beta-lactamase ADC-329
        blaADC-330       NG_156992.1 WP_272357959.1     extended-spectrum class C beta-lactamase ADC-330
        blaADC-331       NG_156993.1 WP_272305010.1     extended-spectrum class C beta-lactamase ADC-331
        blaADC-332       NG_156994.1 WP_272289597.1     extended-spectrum class C beta-lactamase ADC-332
        blaADC-333       NG_156995.1 WP_272321894.1     extended-spectrum class C beta-lactamase ADC-333
        blaCAE-1         NG_156996.1 WP_158386862.1     broad-spectrum class A beta-lactamase CAE-1
        blaCMH-10        NG_156997.1 WP_155023054.1     class C beta-lactamase CMH-10
        blaCMH-11        NG_157062.1 WP_279383145.1     class C beta-lactamase CMH-11
        blaCMH-12        NG_157063.1 WP_279383146.1     class C beta-lactamase CMH-12
        blaCMH-9         NG_156998.1 WP_058650678.1     class C beta-lactamase CMH-9
        blaFONA-10       NG_156999.1 WP_121606866.1     class A beta-lactamase FONA-10
        blaFONA-11       NG_157000.1 WP_021806421.1     class A beta-lactamase FONA-11
        blaFONA-12       NG_157001.1 WP_209522946.1     class A beta-lactamase FONA-12
        blaFONA-13       NG_157002.1 WP_279240771.1     class A beta-lactamase FONA-13
        blaFONA-8        NG_157003.1 WP_024530279.1     class A beta-lactamase FONA-8
        blaFONA-9        NG_157004.1 WP_279240772.1     class A beta-lactamase FONA-9
        blaGES-58        NG_157005.1 WP_279240773.1     class A beta-lactamase GES-58
        blaIMP-99        NG_157006.1 WP_279240774.1     subclass B1 metallo-beta-lactamase IMP-99
        blaKPC-136       NG_157007.1 WP_279240775.1     carbapenem-hydrolyzing class A beta-lactamase KPC-136
        blaKPC-159       NG_157008.1 WP_279240776.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-159
        blaKPC-160       NG_157009.1 WP_279240777.1     carbapenem-hydrolyzing class A beta-lactamase KPC-160
        blaKPC-161       NG_157010.1 WP_279240778.1     carbapenem-hydrolyzing class A beta-lactamase KPC-161
        blaKPC-162       NG_157011.1 WP_279240779.1     carbapenem-hydrolyzing class A beta-lactamase KPC-162
        blaKPC-163       NG_157012.1 WP_279240780.1     carbapenem-hydrolyzing class A beta-lactamase KPC-163
        blaKPC-164       NG_157013.1 WP_279240781.1     carbapenem-hydrolyzing class A beta-lactamase KPC-164
        blaKPC-165       NG_157014.1 WP_279240782.1     carbapenem-hydrolyzing class A beta-lactamase KPC-165
        blaKPC-166       NG_157015.1 WP_279240783.1     carbapenem-hydrolyzing class A beta-lactamase KPC-166
        blaKPC-167       NG_157016.1 WP_279240784.1     class A beta-lactamase KPC-167
        blaNDM-51        NG_157017.1 WP_279240785.1     subclass B1 metallo-beta-lactamase NDM-51
        blaNDM-52        NG_157018.1 WP_279240786.1     subclass B1 metallo-beta-lactamase NDM-52
        blaNDM-53        NG_157019.1 WP_279240787.1     subclass B1 metallo-beta-lactamase NDM-53
        blaNDM-54        NG_157020.1 WP_279240788.1     subclass B1 metallo-beta-lactamase NDM-54
        blaNDM-55        NG_157021.1 WP_279240789.1     subclass B1 metallo-beta-lactamase NDM-55
        blaOXA-1088      NG_157022.1 WP_279240790.1     OXA-10 family class D beta-lactamase OXA-1088
        blaOXA-1109      NG_157023.1 WP_279240791.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1109
        blaOXA-1110      NG_157024.1 WP_253114439.1     OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1110
        blaOXA-1111      NG_157025.1 WP_279240792.1     OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1111
        blaOXA-1112      NG_157026.1 WP_253147258.1     OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1112
        blaOXA-1113      NG_157027.1 WP_279240793.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1113
        blaOXA-1114      NG_157028.1 WP_262451630.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1114
        blaOXA-1115      NG_157029.1 WP_279240794.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1115
        blaOXA-1116      NG_157030.1 WP_279240795.1     OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1116
        blaOXA-1186      NG_157031.1 WP_279240796.1     OXA-198 family carbapenem-hydrolyzing class D beta-lactamase OXA-1186
        blaOXA-1187      NG_157032.1 WP_279240797.1     OXA-2 family class D beta-lactamase OXA-1187
        blaOXA-1188      NG_157033.1 WP_200582679.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1188
        blaOXA-1189      NG_157034.1 WP_009388658.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1189
        blaOXA-1190      NG_157035.1 WP_139419258.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1190
        blaOXA-1191      NG_157036.1 WP_058968329.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1191
        blaOXA-1192      NG_157037.1 WP_274945001.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1192
        blaOXA-1193      NG_157038.1 WP_151798075.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1193
        blaOXA-1194      NG_157039.1 WP_199935335.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1194
        blaOXA-1195      NG_157040.1 WP_151825371.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1195
        blaOXA-1196      NG_157041.1 WP_151810644.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1196
        blaOXA-1197      NG_157042.1 WP_151713720.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1197
        blaOXA-1198      NG_157043.1 WP_279240798.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1198
        blaOXA-1199      NG_157066.1 WP_034021370.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1199
        blaPDC-513       NG_157044.1 WP_279240799.1     class C beta-lactamase PDC-513
        blaPDC-543       NG_157045.1 WP_279240800.1     class C beta-lactamase PDC-543
        blaPDC-544       NG_157046.1 WP_279240801.1     class C beta-lactamase PDC-544
        blaPDC-545       NG_157047.1 WP_279240802.1     class C beta-lactamase PDC-545
        blaPDC-546       NG_157048.1 WP_209359118.1     class C beta-lactamase PDC-546
        blaPDC-547       NG_157049.1 WP_275802705.1     class C beta-lactamase PDC-547
        blaPDC-548       NG_157050.1 WP_279240803.1     class C beta-lactamase PDC-548
        blaPDC-549       NG_157051.1 WP_279240804.1     class C beta-lactamase PDC-549
        blaPDC-550       NG_157052.1 WP_279240805.1     class C beta-lactamase PDC-550
        blaPDC-551       NG_157053.1 WP_279240806.1     class C beta-lactamase PDC-551
        blaPDC-552       NG_157054.1 WP_279240807.1     class C beta-lactamase PDC-552
        blaRAHN-3        NG_157055.1 WP_013578129.1     extended-spectrum class A beta-lactamase RAHN-3
        blaRAHN-4        NG_157056.1 WP_112286530.1     extended-spectrum class A beta-lactamase RAHN-4
        blaRAHN-5        NG_157057.1 WP_279240808.1     extended-spectrum class A beta-lactamase RAHN-5
        blaRAHN-6        NG_157058.1 WP_113877255.1     extended-spectrum class A beta-lactamase RAHN-6
        blaTEM-250       NG_157060.1 WP_279240809.1     class A beta-lactamase TEM-250
        blaVIM-81        NG_157061.1 WP_258164747.1     subclass B1 metallo-beta-lactamase VIM-81
Added point mutations
    core AMR POINT
        amgS_P381S       CARBAPENEM Pseudomonas_aeruginosa
        amgS_R182C       AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        amgS_V121G       AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        ampD_E67STOP     CEPHALOSPORIN Pseudomonas_aeruginosa
        ampD_Q155STOP    CEPHALOSPORIN Pseudomonas_aeruginosa
        ampD_Q44STOP     CEPHALOSPORIN Pseudomonas_aeruginosa
        ampR_R86C        CEPHALOSPORIN Pseudomonas_aeruginosa
        cirA_R86S        CEFIDEROCOL Escherichia
        cmrA_A68V        CHLORAMPHENICOL/IMIPENEM/QUINOLONE Pseudomonas_aeruginosa
        cmrA_H204L       CHLORAMPHENICOL/IMIPENEM/QUINOLONE Pseudomonas_aeruginosa
        cmrA_L89Q        CHLORAMPHENICOL/IMIPENEM/QUINOLONE Pseudomonas_aeruginosa
        cmrA_N214K       CHLORAMPHENICOL/IMIPENEM/QUINOLONE Pseudomonas_aeruginosa
        colR_D32N        COLISTIN Pseudomonas_aeruginosa
        colS_A106V       COLISTIN Pseudomonas_aeruginosa
        cprS_R241C       COLISTIN Pseudomonas_aeruginosa
        czcS_V194L       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_A419G       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_A454V       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_F507L       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_F533L       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_G63S        CARBAPENEM Pseudomonas_aeruginosa
        ftsI_H394R       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_L434V       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_L461V       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_N427L       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_N427S       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_P527S       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_Q458R       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_Q475R       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_R504C       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_R504L       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_S368L       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_S538L       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_V471G       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_V523A       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_V523M       CARBAPENEM Pseudomonas_aeruginosa
        ftsI_Y367C       CARBAPENEM Pseudomonas_aeruginosa
        fusA1_A555E      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_A595P      TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_E100G      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_G545D      TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_I61M       AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_K504Q      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_L438Q      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_L464V      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_N592I      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_P554L      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_P618L      TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_Q455R      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_Q678L      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_R371C      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_R680C      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_T456A      AMIKACIN Pseudomonas_aeruginosa
        fusA1_T671A      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_T671I      AMIKACIN/TOBRAMYCIN Pseudomonas_aeruginosa
        fusA1_Y552C      AMIKACIN Pseudomonas_aeruginosa
        gyrA_D72G        QUINOLONE Pseudomonas_aeruginosa
        gyrA_D87G        QUINOLONE Citrobacter_freundii
        gyrA_D87G        QUINOLONE Klebsiella_oxytoca
        gyrA_D87G        QUINOLONE Enterobacter_cloacae
        gyrA_D87H        QUINOLONE Enterobacter_cloacae
        gyrA_D87N        QUINOLONE Enterobacter_cloacae
        gyrA_D87N        QUINOLONE Serratia_marcescens
        gyrA_D87Y        QUINOLONE Pseudomonas_aeruginosa
        gyrA_G81C        QUINOLONE Pseudomonas_aeruginosa
        gyrA_G81D        QUINOLONE Pseudomonas_aeruginosa
        gyrA_Q106L       QUINOLONE Pseudomonas_aeruginosa
        gyrA_S83F        QUINOLONE Enterobacter_cloacae
        gyrA_S83I        QUINOLONE Enterobacter_cloacae
        gyrA_S83I        QUINOLONE Serratia_marcescens
        gyrA_S83R        QUINOLONE Serratia_marcescens
        gyrA_S83Y        QUINOLONE Enterobacter_cloacae
        gyrA_T83A        QUINOLONE Pseudomonas_aeruginosa
        gyrA_T83I        QUINOLONE Citrobacter_freundii
        gyrA_T83I        QUINOLONE Klebsiella_oxytoca
        gyrA_Y86N        QUINOLONE Pseudomonas_aeruginosa
        gyrB_A372L       QUINOLONE Pseudomonas_aeruginosa
        gyrB_A372V       QUINOLONE Pseudomonas_aeruginosa
        gyrB_E468D       QUINOLONE Pseudomonas_aeruginosa
        gyrB_E468H       QUINOLONE Pseudomonas_aeruginosa
        gyrB_E483D       QUINOLONE Pseudomonas_aeruginosa
        gyrB_I424L       QUINOLONE Pseudomonas_aeruginosa
        gyrB_L464I       QUINOLONE Pseudomonas_aeruginosa
        gyrB_S466F       QUINOLONE Pseudomonas_aeruginosa
        gyrB_S466Y       QUINOLONE Pseudomonas_aeruginosa
        mexR_L57P        CEPHALOSPORIN Pseudomonas_aeruginosa
        mexR_R70Q        CEPHALOSPORIN Pseudomonas_aeruginosa
        mexR_R83C        CARBAPENEM Pseudomonas_aeruginosa
        mexT_G300S       CHLORAMPHENICOL/QUINOLONE/TRIMETHOPRIM Pseudomonas_aeruginosa
        nalC_K58E        CARBAPENEM Pseudomonas_aeruginosa
        nalC_S127P       CARBAPENEM Pseudomonas_aeruginosa
        nalD_F198L       AZTREONAM Pseudomonas_aeruginosa
        nfxB_A38G        QUINOLONE Pseudomonas_aeruginosa
        nfxB_R42G        QUINOLONE Pseudomonas_aeruginosa
        nfxB_R42H        COLISTIN Pseudomonas_aeruginosa
        nfxB_T39P        QUINOLONE Pseudomonas_aeruginosa
        oprD_E176STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_E264STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_G317R       CARBAPENEM Pseudomonas_aeruginosa
        oprD_L11P        CARBAPENEM Pseudomonas_aeruginosa
        oprD_Q250STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_S223P       CARBAPENEM Pseudomonas_aeruginosa
        oprD_S251STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_S319STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_W277STOP    CARBAPENEM Pseudomonas_aeruginosa
        parC_S80I        QUINOLONE Klebsiella_oxytoca
        parC_S80I        QUINOLONE Enterobacter_cloacae
        parC_S80R        QUINOLONE Klebsiella_oxytoca
        parC_S87W        QUINOLONE Pseudomonas_aeruginosa
        parE_E459D       QUINOLONE Pseudomonas_aeruginosa
        parE_E459L       QUINOLONE Pseudomonas_aeruginosa
        parE_S457G       QUINOLONE Pseudomonas_aeruginosa
        parE_S457T       QUINOLONE Pseudomonas_aeruginosa
        parS_A296P       COLISTIN Pseudomonas_aeruginosa
        parS_G361R       COLISTIN Pseudomonas_aeruginosa
        parS_L14Q        CARBAPENEM Pseudomonas_aeruginosa
        parS_V295L       COLISTIN Pseudomonas_aeruginosa
        phoP_N188H       COLISTIN Pseudomonas_aeruginosa
        phoP_N188Y       COLISTIN Pseudomonas_aeruginosa
        pmrA_L157Q       COLISTIN Pseudomonas_aeruginosa
        pmrB_A247T       COLISTIN Pseudomonas_aeruginosa
        pmrB_A248V       COLISTIN Pseudomonas_aeruginosa
        pmrB_A54V        COLISTIN Pseudomonas_aeruginosa
        pmrB_D47del      COLISTIN Pseudomonas_aeruginosa
        pmrB_G188D       COLISTIN Pseudomonas_aeruginosa
        pmrB_L14P        COLISTIN Pseudomonas_aeruginosa
        pmrB_L167P       COLISTIN Pseudomonas_aeruginosa
        pmrB_L17Q        COLISTIN Pseudomonas_aeruginosa
        pmrB_L243Q       COLISTIN Pseudomonas_aeruginosa
        pmrB_M292T       COLISTIN Pseudomonas_aeruginosa
        pmrB_P456S       COLISTIN Pseudomonas_aeruginosa
        pmrB_R259H       COLISTIN Pseudomonas_aeruginosa
        pmrB_S257D       COLISTIN Pseudomonas_aeruginosa
        pmrB_T253M       COLISTIN Pseudomonas_aeruginosa
        pmrB_V281I       COLISTIN Pseudomonas_aeruginosa
        pmrB_V9A         COLISTIN Pseudomonas_aeruginosa
        rplB_G138D       TOBRAMYCIN Pseudomonas_aeruginosa
        rplB_G138L       AMIKACIN Pseudomonas_aeruginosa
Changed reference gene catalog records
    floR WP_000214123.1
        pubmed_reference: <empty> -> 10991873,15855539
    mef(A) WP_000417517.1
        pubmed_reference: <empty> -> 8971709
    mef(A) WP_000417519.1
        pubmed_reference: <empty> -> 9333056
    msr(D) WP_000420313.1
        pubmed_reference: <empty> -> 11398110
    sat4 WP_000627290.1
        pubmed_reference: <empty> -> 11600397
    lnu(A) WP_000700648.1
        pubmed_reference: <empty> -> 17329268
    mecA WP_000721309.1
        pubmed_reference: <empty> -> 11302791,12654286
    mecA WP_000721310.1
        pubmed_reference: <empty> -> 11418146
    blaZ WP_000733285.1
        pubmed_reference: <empty> -> 11418146
    bla2 WP_000799223.1
        pubmed_reference: <empty> -> 12533457
    mecR1 WP_000952923.1
        pubmed_reference: <empty> -> 11418146
    aacA57-2 WP_000959805.1
        pubmed_reference: <empty> -> 9371347
        subclass:        AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
    sul2 WP_001043260.1
        pubmed_reference: <empty> -> 11600347
    tet(B) WP_001089068.1
        pubmed_reference: <empty> -> 11553538
    aadA1 WP_001206317.1
        pubmed_reference: <empty> -> 1334268,2821509
    aadA1 WP_001209508.1
        pubmed_reference: <empty> -> 11114922
    bleO WP_001242578.1
        pubmed_reference: <empty> -> 12654286
    ant(6)-Ia WP_001255866.1
        pubmed_reference: <empty> -> 11600397
    tet(C) WP_001297013.1
        pubmed_reference: <empty> -> 12151232
    aadA7 WP_001436322.1
        pubmed_reference: <empty> -> 10817710
    floR WP_001694495.1
        pubmed_reference: <empty> -> 11101601
    floR WP_001747811.1
        pubmed_reference: <empty> -> 10339826
    lnu(A) WP_001829870.1
        pubmed_reference: <empty> -> 17329268
    dfrA15 WP_001830196.1
        pubmed_reference: <empty> -> 10681329
    vanX-B WP_002317266.1
        pubmed_reference: <empty> -> 11376048
    vanR-B WP_002317273.1
        pubmed_reference: <empty> -> 11376048
    vanS-B WP_002382867.1
        pubmed_reference: <empty> -> 10846226
    vanH-B WP_002382874.1
        pubmed_reference: <empty> -> 11376048
    catA WP_002403315.1
        pubmed_reference: <empty> -> 11257023
    vanY-B WP_002416070.1
        pubmed_reference: <empty> -> 10846226
    catP WP_002570989.1
        pubmed_reference: <empty> -> 7565113
    catB7 WP_003112709.1
        pubmed_reference: <empty> -> 10361706
    vanR-C WP_003126775.1
        pubmed_reference: <empty> -> 10817725
    vanT-C WP_003126777.1
        pubmed_reference: <empty> -> 10209740,10817725
    vanXY-C WP_003126779.1
        pubmed_reference: <empty> -> 10564477,10817725
    blaC WP_003410677.1
        pubmed_reference: <empty> -> 9145897
    tet(V) WP_003896589.1
        pubmed_reference: <empty> -> 9687386
    lnu(AN2) WP_004308783.1
        pubmed_reference: <empty> -> 10852890
    vanR-C WP_005228837.1
        pubmed_reference: <empty> -> 12234834
    vanXY-C WP_005228842.1
        pubmed_reference: <empty> -> 19216682
    vanC WP_005228844.1
        pubmed_reference: <empty> -> 19216682
    cmx WP_005297378.1
        pubmed_reference: <empty> -> 10732668
    ampC WP_006178946.1
        hierarchy_node:  CMY2-MIR-ACT-EC -> ampC_Ecan
        product_name:    CMY2/MIR/ACT/EC family class C beta-lactamase -> CMY2-MIR-ACT-EC family cephalosporin-hydrolyzing class C beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    tetA(P) WP_006440994.1
        pubmed_reference: <empty> -> 11524166
    vanXY-C WP_008377360.1
        pubmed_reference: <empty> -> 19216682
    tet(B) WP_010446567.1
        pubmed_reference: <empty> -> 12957921
    str WP_010711054.1
        pubmed_reference: <empty> -> 11257023
    vanXY-C WP_010749757.1
        pubmed_reference: <empty> -> 12615874
    erm(C) WP_010889933.1
        pubmed_reference: <empty> -> 3084450,3091582
    aph(3')-Id WP_010891085.1
        pubmed_reference: <empty> -> 2653965
    tet(30) WP_010973639.1
        pubmed_reference: <empty> -> 9882678
    tet(C) WP_010981361.1
        pubmed_reference: <empty> -> 12151232
    erm(X) WP_011116967.1
        pubmed_reference: <empty> -> 8559800
    tetB WP_011116970.1
        pubmed_reference: <empty> -> 10220896
    erm(T) WP_011117197.1
        pubmed_reference: <empty> -> 11375658
    lnu(A) WP_011645010.1
        pubmed_reference: <empty> -> 17329268
    lnu(A) WP_011645013.1
        pubmed_reference: <empty> -> 17329268
    lnu(A) WP_011645015.1
        pubmed_reference: <empty> -> 17329268
    erm(B) WP_011861426.1
        pubmed_reference: <empty> -> 10639372,11577151
    blaPEN-E WP_011882713.1
        pubmed_reference: <empty> -> 19075063
    tet(B) WP_014386815.1
        pubmed_reference: <empty> -> 12957921
    vanB WP_014387148.1
        pubmed_reference: <empty> -> 15616278
    tet(O/32/O) WP_015573056.1
        pubmed_reference: <empty> -> 11600392
    vanR-D WP_016295750.1
        pubmed_reference: <empty> -> 15308604
    aph(2'')-IIa WP_016439437.1
        pubmed_reference: <empty> -> 10991878
    mef(A) WP_018374806.1
        pubmed_reference: <empty> -> 14605159
    vanG WP_021418924.1
        pubmed_reference: <empty> -> 14617152
    vanU-G WP_021418929.1
        pubmed_reference: <empty> -> 14617152
    aadA6 WP_022675713.1
        pubmed_reference: <empty> -> 10673049
    vanS-D WP_023042297.1
        pubmed_reference: <empty> -> 15308604
    vanH-D WP_023042299.1
        pubmed_reference: <empty> -> 15308604
    vanD WP_023042300.1
        pubmed_reference: <empty> -> 15308604
    vanH-D WP_028530134.1
        pubmed_reference: <empty> -> 10835012
    tet(B) WP_031942563.1
        pubmed_reference: <empty> -> 6298728,6319234
    tet(G) WP_032488557.1
        pubmed_reference: <empty> -> 1479961
    nimA WP_032488596.1
        pubmed_reference: <empty> -> 8067736
    erm(C) WP_032489009.1
        pubmed_reference: <empty> -> 9169203
    erm(C) WP_032489010.1
        pubmed_reference: <empty> -> 9215582
    erm(C) WP_032489011.1
        pubmed_reference: <empty> -> 9215582
    erm(C) WP_032489016.1
        pubmed_reference: <empty> -> 9742700
    aadA1 WP_032489308.1
        pubmed_reference: <empty> -> 9835490
    vgb(A) WP_032489636.1
        pubmed_reference: <empty> -> 3149758
    vat(E) WP_032489640.1
        pubmed_reference: <empty> -> 10602747
    erm(B) WP_032489723.1
        pubmed_reference: <empty> -> 11023445
    vanR-B WP_032489743.1
        pubmed_reference: <empty> -> 10846226
    vanW-B WP_032489744.1
        pubmed_reference: <empty> -> 10846226
    vanH-B WP_032489745.1
        pubmed_reference: <empty> -> 10846226
    vanB WP_032489746.1
        pubmed_reference: <empty> -> 10846226
    vanX-B WP_032489747.1
        pubmed_reference: <empty> -> 10846226
    aac(6')-Ia WP_032489895.1
        pubmed_reference: <empty> -> 11114922
    cmlA5 WP_032489896.1
        pubmed_reference: <empty> -> 11114922
    vga(B) WP_032490156.1
        pubmed_reference: <empty> -> 9427556
    aadA1 WP_032490440.1
        pubmed_reference: <empty> -> 19719593
    aadA1 WP_032490443.1
        pubmed_reference: <empty> -> 19719593
    aadA5 WP_032490444.1
        pubmed_reference: <empty> -> 19719593
    aadA1 WP_032490451.1
        pubmed_reference: <empty> -> 19719593
    tet(H) WP_032490787.1
        pubmed_reference: <empty> -> 8109938
    aac(3)-Ia WP_032491356.1
        pubmed_reference: <empty> -> 9835490
    aac(3)-Ia WP_032492247.1
        pubmed_reference: <empty> -> 2549372
    blaL1 WP_032966056.1
        pubmed_reference: <empty> -> 9593158
    vanR-C WP_034872470.1
        pubmed_reference: <empty> -> 19216682
    blaSRT WP_047567658.1
        pubmed_reference: <empty> -> 11451693
    tet(O) WP_050824634.1
        pubmed_reference: <empty> -> 15184185
    aac(6')-Ian WP_051139090.1
        pubmed_reference: <empty> -> 9371347
    vanB WP_060763488.1
        pubmed_reference: <empty> -> 15616278
    vanC WP_060792851.1
        pubmed_reference: <empty> -> 19216682
    vanXY-C WP_060792852.1
        pubmed_reference: <empty> -> 19216682
    ampC WP_063406924.1
        hierarchy_node:  CMY2-MIR-ACT-EC -> ampC_Kaer
        product_name:    CMY2/MIR/ACT/EC family class C beta-lactamase -> CMY2-MIR-ACT-EC family cephalosporin-hydrolyzing class C beta-lactamase
        pubmed_reference: <empty> -> 11036041
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    aac(3)-Ia WP_063840257.1
        pubmed_reference: <empty> -> 19719593
    aadA4 WP_063840443.1
        pubmed_reference: <empty> -> 10639362
    aadA8 WP_063840457.1
        pubmed_reference: <empty> -> 11557503
    aph(3')-IIIa WP_063841495.1
        pubmed_reference: <empty> -> 11600397
    blaL1 WP_063842669.1
        pubmed_reference: <empty> -> 11158734
    blaL1 WP_063842676.1
        pubmed_reference: <empty> -> 11158734
    catA1 WP_063843218.1
        pubmed_reference: <empty> -> 11553538
    cfxA WP_063843238.1
        pubmed_reference: <empty> -> 12697645
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        pubmed_reference: <empty> -> 19216682
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        pubmed_reference: <empty> -> 19216682
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        pubmed_reference: <empty> -> 10835012
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        pubmed_reference: <empty> -> 9687406
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        pubmed_reference: <empty> -> 11557494
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        pubmed_reference: <empty> -> 11557494
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        pubmed_reference: <empty> -> 11055933
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        pubmed_reference: <empty> -> 19719593
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        pubmed_reference: <empty> -> 15184185
    aac(6')-Ii WP_008265821.1
        pubmed_reference: <empty> -> 8239603
    ampC_Asob-1 WP_063840463.1
        allele:          <empty> -> ampC_Asob-1
        hierarchy_node:  blaCMY-FOX -> ampC_Asob-1
        product_name:    FOX/MOX family class C beta-lactamase -> FOX/MOX family cephalosporin-hydrolyzing class C beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    ampC_Sliq-1 WP_063840466.1
        allele:          <empty> -> ampC_Sliq-1
        hierarchy_node:  bla-C -> ampC_Sliq-1
        product_name:    class C beta-lactamase -> cephalosporin-hydrolyzing class C beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        pubmed_reference: <empty> -> 10817695
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        pubmed_reference: <empty> -> 10817695
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        pubmed_reference: <empty> -> 10817695
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        pubmed_reference: <empty> -> 10817695
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        pubmed_reference: <empty> -> 28082950
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        pubmed_reference: <empty> -> 28082950
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        pubmed_reference: <empty> -> 10817691
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        pubmed_reference: <empty> -> 10817691
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        pubmed_reference: <empty> -> 10817691
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        pubmed_reference: <empty> -> 10858348
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        pubmed_reference: <empty> -> 28082950
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        pubmed_reference: <empty> -> 28082950
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        pubmed_reference: <empty> -> 28082950
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        pubmed_reference: <empty> -> 28082950
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        pubmed_reference: <empty> -> 11709346
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        pubmed_reference: <empty> -> 35980232
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        pubmed_reference: <empty> -> 35980232
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        pubmed_reference: <empty> -> 35980232
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        pubmed_reference: <empty> -> 35980232
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        pubmed_reference: <empty> -> 35980188
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        pubmed_reference: <empty> -> 35794918
    blaKPC-157 WP_259115967.1
        genbank_nucleotide_accession: JAPQEX010000069.1 -> JAPQEX020000004.1
        genbank_protein_accession: MCY6378833.1 -> MDG1646356.1
        genbank_start:   2109 -> 57057
        genbank_stop:    2990 -> 57938
    blaKPC-25 WP_065419571.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-25 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-25
        pubmed_reference: 34290688 -> 28223379,34290688
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-26 WP_068981634.1
        pubmed_reference: <empty> -> 28971868
    blaKPC-44 WP_140423311.1
        pubmed_reference: <empty> -> 31088601
    blaKPC-48 WP_213994589.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-48 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-48
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-76 WP_194293135.1
        product_name:    class A beta-lactamase KPC-76 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-76
        pubmed_reference: 34935416 -> 34935416,35588280
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-84 WP_213994590.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-84 -> inhibitor-resistant extended-spectrum carbapenem-hydrolyzing class A beta-lactamase KPC-84
        pubmed_reference: <empty> -> 26100712,35980232
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-92 WP_240067725.1
        pubmed_reference: <empty> -> 35107303
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        pubmed_reference: <empty> -> 35980232
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        pubmed_reference: <empty> -> 35980232
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        pubmed_reference: <empty> -> 9231418
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        product_name:    CMY-1/MOX family class C beta-lactamase MOX-18 -> class C beta-lactamase MOX-18
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        product_name:    CMY-1/MOX family class C beta-lactamase MOX-19 -> class C beta-lactamase MOX-19
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        product_name:    CMY-1/MOX family class C beta-lactamase MOX-20 -> class C beta-lactamase MOX-20
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        product_name:    CMY-1/MOX family class C beta-lactamase MOX-21 -> class C beta-lactamase MOX-21
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        product_name:    CMY-1/MOX family class C beta-lactamase MOX-22 -> class C beta-lactamase MOX-22
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        product_name:    CMY-1/MOX family class C beta-lactamase MOX-23 -> class C beta-lactamase MOX-23
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        product_name:    CMY-1/MOX family class C beta-lactamase MOX-24 -> class C beta-lactamase MOX-24
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        product_name:    CMY-1/MOX family class C beta-lactamase MOX-25 -> class C beta-lactamase MOX-25
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        pubmed_reference: <empty> -> 29515538
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        pubmed_reference: <empty> -> 34207702,34659178
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        pubmed_reference: <empty> -> 11557499
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        pubmed_reference: <empty> -> 18694786
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        pubmed_reference: <empty> -> 18694786
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        pubmed_reference: <empty> -> 18694786
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        pubmed_reference: <empty> -> 18694786
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        pubmed_reference: <empty> -> 18694786
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        product_name:    OXA-427 family class D beta-lactamase OXA-1041 -> OXA-427 family carbapenem-hydrolyzing class D beta-lactamase OXA-1041
        pubmed_reference: <empty> -> 36995982
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1052 WP_256875607.1
        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        pubmed_reference: <empty> -> 15155197
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        pubmed_reference: <empty> -> 15155197
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        pubmed_reference: <empty> -> 15155197
    blaOXA-895 WP_100886243.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-930 WP_151781119.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-931 WP_190259776.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-952 WP_213994598.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-953 WP_049044515.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-983 WP_231869608.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaPDC-166 WP_065102306.1
        product_name:    class C beta-lactamase PDC-166 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-166
        pubmed_reference: <empty> -> 26248364
    blaPDC-186 WP_087587956.1
        product_name:    class C beta-lactamase PDC-186 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-186
        pubmed_reference: <empty> -> 26248364
    blaPDC-221 WP_100931731.1
        pubmed_reference: 29149337,34930034 -> 26248364,29149337,34930034
    blaPDC-222 WP_100931732.1
        pubmed_reference: 29149337 -> 29149337,32660987
    blaPDC-224 WP_101244936.1
        product_name:    class C beta-lactamase PDC-224 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-224
        pubmed_reference: <empty> -> 26248364
    blaPDC-228 WP_104009857.1
        product_name:    class C beta-lactamase PDC-228 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-228
        pubmed_reference: <empty> -> 26248364,32660987
    blaPDC-243 WP_104009840.1
        product_name:    class C beta-lactamase PDC-243 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-243
        pubmed_reference: <empty> -> 32660987
    blaPDC-245 WP_100831609.1
        pubmed_reference: 31636072 -> 31636072,32660987
    blaPDC-267 WP_109791201.1
        product_name:    class C beta-lactamase PDC-267 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-267
        pubmed_reference: <empty> -> 26248364
    blaPDC-270 WP_109791203.1
        pubmed_reference: 31636072 -> 31636072,32660987
    blaPDC-300 WP_111672889.1
        product_name:    class C beta-lactamase PDC-300 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-300
        pubmed_reference: <empty> -> 26248364
    blaPDC-306 WP_116786838.1
        product_name:    class C beta-lactamase PDC-306 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-306
        pubmed_reference: <empty> -> 26248364
    blaPDC-309 WP_122630847.1
        product_name:    class C beta-lactamase PDC-309 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-309
        pubmed_reference: <empty> -> 26248364
    blaPDC-321 WP_150823480.1
        product_name:    class C beta-lactamase PDC-321 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-321
        pubmed_reference: <empty> -> 26248364
    blaPDC-322 WP_138403314.1
        pubmed_reference: 31636072 -> 31636072,32660987
    blaPDC-325 WP_150823483.1
        pubmed_reference: <empty> -> 26248364
    blaPDC-327 WP_150823485.1
        product_name:    class C beta-lactamase PDC-327 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-327
        pubmed_reference: <empty> -> 26248364
    blaPDC-329 WP_150823487.1
        product_name:    class C beta-lactamase PDC-329 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-329
        pubmed_reference: <empty> -> 26248364
    blaPDC-334 WP_148044426.1
        product_name:    class C beta-lactamase PDC-334 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-334
        pubmed_reference: <empty> -> 32660987
    blaPDC-336 WP_148044428.1
        product_name:    class C beta-lactamase PDC-336 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-336
        pubmed_reference: <empty> -> 26248364
    blaPDC-337 WP_148044429.1
        product_name:    class C beta-lactamase PDC-337 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-337
        pubmed_reference: <empty> -> 26248364
    blaPDC-340 WP_148044432.1
        product_name:    class C beta-lactamase PDC-340 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-340
        pubmed_reference: <empty> -> 26248364
    blaPDC-345 WP_148044437.1
        product_name:    class C beta-lactamase PDC-345 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-345
        pubmed_reference: <empty> -> 26248364
    blaPDC-346 WP_148044438.1
        pubmed_reference: 31636072 -> 31636072,32660987
    blaPDC-373 WP_148044460.1
        product_name:    class C beta-lactamase PDC-373 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-373
        pubmed_reference: <empty> -> 26248364,32660987
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        pubmed_reference: 31636072 -> 31636072,32660987
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        pubmed_reference: <empty> -> 32660987
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        product_name:    class C beta-lactamase PDC-387 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-387
        pubmed_reference: <empty> -> 32660987
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        product_name:    class C beta-lactamase PDC-391 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-391
        pubmed_reference: <empty> -> 32660987
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        product_name:    class C beta-lactamase PDC-394 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-394
        pubmed_reference: <empty> -> 26248364
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        pubmed_reference: <empty> -> 26248364
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        pubmed_reference: <empty> -> 26248364
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        pubmed_reference: <empty> -> 32660987
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        pubmed_reference: <empty> -> 26248364
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        pubmed_reference: <empty> -> 32660987
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        pubmed_reference: 31636072 -> 31636072,32660987
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        product_name:    class C beta-lactamase PDC-446 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-446
        pubmed_reference: <empty> -> 26248364
    blaPDC-448 WP_179284385.1
        product_name:    class C beta-lactamase PDC-448 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-448
        pubmed_reference: <empty> -> 26248364,32660987
    blaPDC-468 WP_204376241.1
        pubmed_reference: 31636072 -> 31636072,32660987
    blaPDC-469 WP_204376242.1
        product_name:    class C beta-lactamase PDC-469 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-469
        pubmed_reference: <empty> -> 26248364
    blaPDC-472 WP_204376245.1
        product_name:    class C beta-lactamase PDC-472 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-472
        pubmed_reference: <empty> -> 26248364
    blaPDC-475 WP_204378710.1
        product_name:    class C beta-lactamase PDC-475 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-475
        pubmed_reference: <empty> -> 32660987
    blaPDC-479 WP_213994607.1
        product_name:    class C beta-lactamase PDC-479 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-479
        pubmed_reference: <empty> -> 26248364
    blaPDC-480 WP_213994608.1
        product_name:    class C beta-lactamase PDC-480 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-480
        pubmed_reference: <empty> -> 26248364,32660987
    blaPDC-481 WP_213994609.1
        product_name:    class C beta-lactamase PDC-481 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-481
        pubmed_reference: <empty> -> 26248364
    blaPDC-482 WP_213994610.1
        product_name:    inhibitor-resistant class C beta-lactamase PDC-482 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-482
        pubmed_reference: 34930034 -> 26248364,34930034
    blaPDC-483 WP_213994611.1
        pubmed_reference: 34930034 -> 32660987,34930034
    blaPDC-487 WP_219860724.1
        product_name:    class C beta-lactamase PDC-487 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-487
        pubmed_reference: <empty> -> 26248364
    blaPDC-497 WP_231869635.1
        product_name:    class C beta-lactamase PDC-497 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-497
        pubmed_reference: <empty> -> 26248364
    blaPDC-500 WP_231873784.1
        pubmed_reference: 31636072 -> 31636072,32660987
    blaPDC-510 WP_240067745.1
        pubmed_reference: 31636072 -> 31636072,32660987
    blaPDC-515 WP_242934123.1
        product_name:    class C beta-lactamase PDC-515 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-515
        pubmed_reference: <empty> -> 26248364
    blaPDC-531 WP_262697184.1
        product_name:    class C beta-lactamase PDC-531 -> inhibitor-resistant class C beta-lactamase PDC-531
        pubmed_reference: <empty> -> 32660987
    blaPDC-537 WP_243210688.1
        product_name:    class C beta-lactamase PDC-537 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-537
        pubmed_reference: <empty> -> 26248364
    blaPDC-74 WP_040184286.1
        product_name:    extended-spectrum class C beta-lactamase PDC-74 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-74
    blaPDC-86 WP_058198950.1
        product_name:    extended-spectrum class C beta-lactamase PDC-86 -> inhibitor-resistant extended-spectrum class C beta-lactamase PDC-86
    blaPEN-B2 WP_262697188.1
        pubmed_reference: <empty> -> 19075063
    blaPEN-B3 WP_262697189.1
        pubmed_reference: <empty> -> 19075063
    blaPEN-B4 WP_163122236.1
        pubmed_reference: <empty> -> 19075063
    blaPLA-3 WP_032696109.1
        pubmed_reference: <empty> -> 18694786
    blaPLA-4 WP_032687534.1
        pubmed_reference: <empty> -> 18694786
    blaRAD-1 WP_004919358.1
        pubmed_reference: <empty> -> 36883515
    blaRAHN-1 WP_063864600.1
        pubmed_reference: <empty> -> 11557504
    blaRATA-1 WP_064964607.1
        genbank_nucleotide_accession: LUDJ01000009.1 -> CP121209.1
        genbank_protein_accession: OBP43755.1 -> WFS34552.1
        genbank_start:   257 -> 1982453
        genbank_stop:    1171 -> 1983367
        genbank_strand:  - -> +
    blaROB-1 WP_005618523.1
        pubmed_reference: <empty> -> 2201253
    blaSFC-1 WP_024531321.1
        pubmed_reference: <empty> -> 15155245
    blaSPN79-1 WP_122630830.1
        pubmed_reference: <empty> -> 28082950
    blaVEB-9 WP_032494864.1
        pubmed_reference: <empty> -> 11384532
    blaVHH-1 WP_063865164.1
        pubmed_reference: <empty> -> 10770767
    blaVHW-1 WP_063865165.1
        pubmed_reference: <empty> -> 10770767
    cfiA10 WP_063865205.1
        pubmed_reference: <empty> -> 12604530
    cfiA2 WP_015083750.1
        pubmed_reference: <empty> -> 12604530
    cfiA4 WP_005821510.1
        pubmed_reference: <empty> -> 12604530
    cfiA8 WP_063865206.1
        pubmed_reference: <empty> -> 12604530
    cfiA9 WP_063865207.1
        pubmed_reference: <empty> -> 12604530
    cphA2 WP_063865208.1
        pubmed_reference: <empty> -> 1856163
    dfrA13 WP_063844334.1
        pubmed_reference: <empty> -> 10639362
    fosA WP_038415208.1
        pubmed_reference: <empty> -> 1963292
    gyrA_D87G WP_001281243.1
        pubmed_reference: <empty> -> 9756773
    gyrA_T83I WP_003091448.1
        pubmed_reference: 8540700 -> 8540700,33875431
    lnu(A)' WP_011428879.1
        pubmed_reference: <empty> -> 17329268
    oprD_Q142STOP WP_003112576.1
        pubmed_reference: 27736752 -> 27736752,29681898
    rmtE1 WP_063866478.1
        product_name:    16S rRNA (guanine(1405)-N(7))-methyltransferase RmtE -> 16S rRNA (guanine(1405)-N(7))-methyltransferase RmtE1
    vanS-B-Delta WP_063856737.1
        pubmed_reference: <empty> -> 14617162

Hierarchy nodes added
    core AMR AMR
        ampC_Ecan        ampC                           CMY2-MIR-ACT-EC family cephalosporin-hydrolyzing class C beta-lactamase
        ampC_Kaer        ampC NF041662.1                CMY2-MIR-ACT-EC family cephalosporin-hydrolyzing class C beta-lactamase
        ampC_Sliq        ampC NF041663.1                cephalosporin-hydrolyzing class C beta-lactamase
        blaCAE           blaCAE NF041590.1              CAE family broad-spectrum class A beta-lactamase
Changed Hierarchy Nodes
    aacA57-2         aminoglycoside N-acetyltransferase AAC(6')-Ian
        subclass:        AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
    blaKHM           KHM family subclass B1 metallo-beta-lactamase
        hmm_acc:         <empty> -> NF041632.1

----------------------------------------------------------------------
Changes included in 2023-02-23.1
----------------------------------------------------------------------

Overview:

    - To conform with Oswaldi et al., 2022 PMID:35336088 and
      https://faculty.washington.edu/marilynr/ we have changed the gene symbol
      for CAC98997.1 from lin to vga(G)
    - The non-core protein previously designated nirA is now recognized to have
      represented a truncated sequence otherwise equivalent to ncrA. The node
      called nirA has been retired.
    - Review of the literature for many beta-lactamases led to improved
      subclass designations and/or product names for many cephalosporinases and
      carbapenemases
    - Continuing curation led to the addition of many pubmed citations
    - Several proteins were removed/replaced becuase they were incorrectly
      extended versions
    - Includes new alleles submitted to NCBI for nomenclature assignment
    - New genes and point mutations identified by our curators in the
      literature including multiple point mutations for Neisseria gonorrhoeae

Summary:
   Total proteins: 7627
        Core proteins: 6536
        Plus proteins: 1090
   AMR proteins: 6584
   STRESS proteins: 235
   VIRULENCE proteins: 808
   PubMed references: 2912
   Point mutations: 1013
   Point mutation reference sequences: 177
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Clostridioides_difficile, Enterococcus_faecalis,
       Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae,
       Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa,
       Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius,
       Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 688

Updates since release 2022-12-19.1:
   Proteins added: 39
       Core proteins added: 39
       Plus proteins added: 0
   AMR proteins added: 39
   Alleles added: 27
   PubMed references added: 294
   PubMed references removed: 1
   Point mutations added: 10
   Proteins removed: 9
       Core proteins removed: 2
       Plus proteins removed: 7
   Reference Gene Catalog entries changed: 303
   Hierarchy nodes added: 13
   Hierarchy nodes removed: 3
   Hierarchy nodes changed: 8

Added proteins
    core AMR AMR
        almF             NG_149645.1 WP_000806242.1     lipid A modification system glycine carrier protein AlmF
        almG             NG_149646.1 WP_001881365.1     glycine--lipid A transferase AlmG
        vanS-I           NG_149654.1 WP_011461302.1     VanI-type vancomycin resistance histidine kinase VanS
        fosXCC           NG_149649.1 WP_024725385.1     fosfomycin resistance hydrolase FosXCC
        thfT             NG_149653.1 WP_048327435.1     reduced folate ECF transporter S component ThfT
        aph(2'')-Ii      NG_149647.1 WP_052776520.1     aminoglycoside O-phosphotransferase APH(2'')-Ii
        lnu(E)           NG_149650.1 WP_063851343.1     lincosamide nucleotidyltransferase Lnu(E)
        sal(D)           NG_149651.1 WP_082039181.1     ABC-F type ribosomal protection protein Sal(D)
        sal(E)           NG_149652.1 WP_096809342.1     ABC-F type ribosomal protection protein Sal(E)
        vga(F)           NG_149655.1 WP_171943877.1     ABC-F type ribosomal protection protein Vga(F)
        almE             NG_149644.1 WP_252944138.1     lipid A modification system glycine--protein ligase AlmE
        aph(2'')-Ii      NG_149648.1 WP_274293081.1     aminoglycoside O-phosphotransferase APH(2'')-Ii
        blaADC-291       NG_149679.1 WP_001211201.1     extended-spectrum class C beta-lactamase ADC-291
        blaB-37          NG_149656.1 WP_078798391.1     subclass B1 metallo-beta-lactamase BlaB-37
        blaCMY-185       NG_149657.1 WP_274293082.1     class C beta-lactamase CMY-185
        blaCTX-M-152     NG_048938.1 WP_064543755.1     extended-spectrum class A beta-lactamase CTX-M-152
        blaIND-17        NG_149680.1 WP_274375789.1     subclass B1 metallo-beta-lactamase IND-17
        blaIND-18        NG_149681.1 WP_274375790.1     subclass B1 metallo-beta-lactamase IND-18
        blaKPC-109       NG_149659.1 WP_274293083.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-109
        blaKPC-155       NG_149660.1 WP_274293084.1     inhibitor-resistant class A beta-lactamase KPC-155
        blaKPC-156       NG_149661.1 WP_274293085.1     carbapenem-hydrolyzing class A beta-lactamase KPC-156
        blaKPC-157       NG_149662.1 WP_259115967.1     carbapenem-hydrolyzing class A beta-lactamase KPC-157
        blaNDM-49        NG_149663.1 WP_274293086.1     subclass B1 metallo-beta-lactamase NDM-49
        blaNDM-50        NG_149664.1 WP_274293087.1     subclass B1 metallo-beta-lactamase NDM-50
        blaOXA-1181      NG_149665.1 WP_274293088.1     OXA-48 family class D beta-lactamase OXA-1181
        blaOXA-1182      NG_149666.1 WP_274293089.1     OXA-143 family carbapenem-hydrolyzing class D beta-lactamase OXA-1182
        blaOXA-1185      NG_149667.1 WP_274293090.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1185
        blaPDC-538       NG_149668.1 WP_274293091.1     class C beta-lactamase PDC-538
        blaPDC-539       NG_149669.1 WP_274293092.1     class C beta-lactamase PDC-539
        blaPDC-540       NG_149682.1 WP_274375791.1     class C beta-lactamase PDC-540
        blaPDC-541       NG_149683.1 WP_274375792.1     class C beta-lactamase PDC-541
        blaPDC-542       NG_149684.1 WP_274375793.1     class C beta-lactamase PDC-542
        blaPJM-2         NG_149670.1 WP_162338672.1     subclass B3 metallo-beta-lactamase PJM-2
        blaRATA-1        NG_149671.1 WP_064964607.1     extended-spectrum class A beta-lactamase RATA-1
        blaRATA-2        NG_149672.1 WP_154469535.1     extended-spectrum class A beta-lactamase RATA-2
        blaVIM-86        NG_149673.1 WP_274293093.1     subclass B1 metallo-beta-lactamase VIM-86
        cfiA29           NG_149674.1 WP_250718547.1     subclass B1 metallo-beta-lactamase CfiA29
        cfiA30           NG_149675.1 WP_234164690.1     subclass B1 metallo-beta-lactamase CfiA30
        cfiA31           NG_149676.1 WP_186993003.1     subclass B1 metallo-beta-lactamase CfiA31
Added point mutations
    core AMR POINT
        ftsI_A498T       CEPHALOSPORIN Escherichia
        glpT_A434V       FOSFOMYCIN Staphylococcus_aureus
        mtrR_G45S        AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria_gonorrhoeae
        parC_D86G        QUINOLONE Neisseria_gonorrhoeae
        parC_E91A        QUINOLONE Neisseria_gonorrhoeae
        parC_E91Q        QUINOLONE Neisseria_gonorrhoeae
        parC_S87C        QUINOLONE Neisseria_gonorrhoeae
        porB1b_A121S     CEPHALOSPORIN/QUINOLONE/TETRACYCLINE Neisseria_gonorrhoeae
        rpoB_H553N       RIFAMPIN Neisseria_gonorrhoeae
        rpoB_L560S       RIFAMPIN Neisseria_gonorrhoeae
Removed proteins
    core AMR AMR
        aph(3'')-Ib      NG_056002.2 WP_109545041.1     aminoglycoside O-phosphotransferase APH(3'')-Ib
        blaCTX-M-152     NG_048938.1 WP_063859961.1     extended-spectrum class A beta-lactamase CTX-M-152
    plus AMR AMR
        almG             AE003852.1 AAF94731.1          glycine--lipid A transferase AlmG
    plus STRESS METAL
        nirA             AY492000.1 AAR82963.1          nickel resistance membrane nickel efflux protein NirA
    plus VIRULENCE VIRULENCE
        iss              AE014075.1 AAN80033.1          increased serum survival lipoprotein Iss
        iss              CP000468.1 ABJ00546.1          increased serum survival lipoprotein Iss
        iss              CU928158.2 CAQ90194.1          increased serum survival lipoprotein Iss
        iss              CU928160.2 CAQ97644.1          increased serum survival lipoprotein Iss
        iroN             FP929040.1 CBK85583.1          siderophore salmochelin receptor IroN
Changed reference gene catalog records
    catB3 WP_000186237.1
        pubmed_reference: <empty> -> 7793874
    armA WP_000359986.1
        pubmed_reference: <empty> -> 16626740
    aph(6)-Id WP_000480968.1
        pubmed_reference: <empty> -> 2653965
    dfrA8 WP_000571065.1
        pubmed_reference: <empty> -> 7867952
    tet(S) WP_000691722.1
        pubmed_reference: <empty> -> 8370538
    tet(M) WP_000691746.1
        pubmed_reference: <empty> -> 16565159
    tet(M) WP_000691749.1
        pubmed_reference: <empty> -> 1323953
    fosB WP_000943772.1
        hierarchy_node:  fosB_gen -> fosBx1-fam
        product_name:    FosB/FosD family fosfomycin resistance bacillithiol transferase -> FosBx1 family fosfomycin resistance bacillithiol transferase
    erm(C) WP_001003263.1
        pubmed_reference: <empty> -> 3087948
    erm(C) WP_001003264.1
        pubmed_reference: <empty> -> 3141573
    aac(6')-Ie/aph(2'')-Ia WP_001028144.1
        pubmed_reference: <empty> -> 2833561
    vanR-A WP_001280781.1
        pubmed_reference: <empty> -> 7867956,8380148
    blaI WP_001284656.1
        pubmed_reference: <empty> -> 1861992
    tet(M) WP_001574275.1
        pubmed_reference: <empty> -> 16565159
    tet(L) WP_001574277.1
        pubmed_reference: <empty> -> 2438417
    vanY-A WP_001812592.1
        pubmed_reference: <empty> -> 7867956,8380148
    vat(D) WP_002295712.1
        pubmed_reference: <empty> -> 8257133
    vanS-A WP_002305818.1
        pubmed_reference: <empty> -> 7867956,8380148
    vanW-B WP_002368694.1
        pubmed_reference: <empty> -> 8631706
    vanY-B WP_002368695.1
        pubmed_reference: <empty> -> 8631706
    vanS-B WP_002368696.1
        pubmed_reference: <empty> -> 8631706
    vanR-B WP_002368697.1
        pubmed_reference: <empty> -> 8631706
    tet(M) WP_002414694.1
        pubmed_reference: <empty> -> 16565159
    erm(F) WP_002682030.1
        pubmed_reference: <empty> -> 2820936
    tet(O) WP_002779752.1
        pubmed_reference: <empty> -> 2836268
    aadE-Cc WP_002785795.1
        hierarchy_node:  aadE-Cc -> ant(6)-Ig
        product_name:    aminoglycoside 6-adenylyltransferase AadE-Cc -> aminoglycoside nucleotidyltransferase ANT(6)-Ig
    erm(D) WP_003183781.1
        pubmed_reference: <empty> -> 1713206
    aadK WP_003229862.1
        pubmed_reference: <empty> -> 2550327
    erm(O) WP_003972831.1
        pubmed_reference: <empty> -> 1761231
    cfxA3 WP_004348227.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    aph(3'')-Ib WP_010890156.1
        pubmed_reference: <empty> -> 2653965
    vga(G) WP_010989615.1
        gene_family:     lin -> vga(G)
        hierarchy_node:  lin -> vga(G)
        product_name:    lmo0919 family lincomycin resistance ABC-F type ribosomal protection protein -> ABC-F type ribosomal protection protein Vga(G)
    cepA WP_010992371.1
        pubmed_reference: <empty> -> 7517394
    blaE WP_011729443.1
        pubmed_reference: <empty> -> 15699201
    tetA(P) WP_012478244.1
        pubmed_reference: <empty> -> 8170402
    erm(G) WP_014387027.1
        pubmed_reference: <empty> -> 3025178
    vanR-D WP_023042613.1
        pubmed_reference: <empty> -> 10368136
    vanX-D WP_023042861.1
        pubmed_reference: <empty> -> 10368136
    erm(D) WP_025811090.1
        pubmed_reference: <empty> -> 6429477
    vanC WP_029487031.1
        pubmed_reference: <empty> -> 1551598,10817725
    cmlA1 WP_032488514.1
        pubmed_reference: <empty> -> 1648560
    catB3 WP_032489305.1
        pubmed_reference: <empty> -> 7793874,9835490
    aadD1 WP_032542910.1
        pubmed_reference: <empty> -> 6090428
    cfxA5 WP_032946415.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    aac(3)-IIb WP_033147097.1
        pubmed_reference: <empty> -> 1444303
    tet(O) WP_044666383.1
        pubmed_reference: <empty> -> 2841293
    blaL1 WP_046430859.1
        pubmed_reference: <empty> -> 19146537
    tcmA WP_052413892.1
        pubmed_reference: <empty> -> 1592819
    cfxA4 WP_057280848.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    aac(3)-IId WP_063840265.1
        pubmed_reference: <empty> -> 8117265
    aac(3)-VIa WP_063840273.1
        pubmed_reference: <empty> -> 8257126
    ampC WP_063840463.1
        pubmed_reference: <empty> -> 7811022
    ant(4')-IIa WP_063840508.1
        pubmed_reference: <empty> -> 8494365
    ant(9)-Ib WP_063840673.1
        pubmed_reference: <empty> -> 1659306
    aph(3'')-Ia WP_063840677.1
        pubmed_reference: <empty> -> 2844130
    blaL1 WP_063842690.1
        pubmed_reference: <empty> -> 19146537
    blaL1 WP_063842691.1
        pubmed_reference: <empty> -> 19146537
    blaL1 WP_063842692.1
        pubmed_reference: <empty> -> 19146537
    blaL1 WP_063842693.1
        pubmed_reference: <empty> -> 19146537
    blaL1 WP_063842694.1
        pubmed_reference: <empty> -> 19146537
    blaL1 WP_063842696.1
        pubmed_reference: <empty> -> 19146537
    blaL1 WP_063842697.1
        pubmed_reference: <empty> -> 19146537
    blaL1 WP_063842698.1
        pubmed_reference: <empty> -> 19146537
    blaL2 WP_063842700.1
        product_name:    L2 family class A beta-lactamase -> L2 family extended-spectrum class A beta-lactamase
        pubmed_reference: <empty> -> 18212097
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    catA WP_063843210.1
        pubmed_reference: <empty> -> 1929326
    erm(B) WP_063844614.1
        pubmed_reference: <empty> -> 6406429
    erm(B) WP_063844619.1
        pubmed_reference: <empty> -> 2832378
    erm(C) WP_063844768.1
        pubmed_reference: <empty> -> 2822666
    erm(E) WP_063844770.1
        pubmed_reference: <empty> -> 2998943,3934045
    erm(F) WP_063844771.1
        pubmed_reference: <empty> -> 1905805
    erm(S) WP_063844819.1
        pubmed_reference: <empty> -> 3127381
    floR WP_063844973.1
        pubmed_reference: <empty> -> 10103189
    grm WP_063851283.1
        pubmed_reference: <empty> -> 2013410
    mgt WP_063853740.1
        pubmed_reference: <empty> -> 1761231
    otr(A) WP_063854498.1
        pubmed_reference: <empty> -> 1510403
    tet(L) WP_063856080.1
        pubmed_reference: <empty> -> 2996983
    tet(M) WP_063856108.1
        pubmed_reference: <empty> -> 2073121
    tet(M) WP_063856110.1
        pubmed_reference: <empty> -> 3344217
    tet(M) WP_063856395.1
        pubmed_reference: <empty> -> 16565159
    tet(M) WP_063856396.1
        pubmed_reference: <empty> -> 16565159
    tet(Q) WP_063856407.1
        pubmed_reference: <empty> -> 7944364
    vanC WP_063856645.1
        pubmed_reference: <empty> -> 16495270
    vanD WP_063856690.1
        pubmed_reference: <empty> -> 10368136
    vanH-D WP_063856703.1
        pubmed_reference: <empty> -> 10368136
    vanH-D WP_063856705.1
        pubmed_reference: <empty> -> 16495270
    vanH-Pt WP_063856708.1
        pubmed_reference: <empty> -> 16189102
    vanH WP_063856709.1
        pubmed_reference: <empty> -> 16189102
    vanR-A WP_063856720.1
        pubmed_reference: <empty> -> 16189102
    vanR-A WP_063856721.1
        pubmed_reference: <empty> -> 16189102
    vanR-D WP_063856722.1
        pubmed_reference: <empty> -> 16495270
    vanS-D WP_063856730.1
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        CARBAPENEM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaTLA-3 WP_059512353.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaTRU-1 WP_042027926.1
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    cepA-29 WP_063865204.1
        pubmed_reference: <empty> -> 7517394
    cepA-44 WP_032579291.1
        pubmed_reference: <empty> -> 7517394
    cepA-49 WP_008659027.1
        pubmed_reference: <empty> -> 7517394
    gyrA_D95A WP_003688895.1
        pubmed_reference: 7830580 -> 7830580,36735316
    gyrA_D95G WP_003688895.1
        pubmed_reference: 7830580 -> 7830580,36735316
    parC_E91G WP_010951227.1
        pubmed_reference: 12529019 -> 12529019,36735316

Hierarchy nodes added
    core AMR AMR
        almE             almE                           lipid A modification system glycine--protein ligase AlmE
        almF             almF                           lipid A modification system glycine carrier protein AlmF
        ant(6)-Ig        aadE-Cc                        aminoglycoside nucleotidyltransferase ANT(6)-Ig
        aph(2'')-Ii      aph(2'')-Ii NF041446.1         aminoglycoside O-phosphotransferase APH(2'')-Ii
        blaRATA          blaRATA NF041445.1             RATA family class A beta-lactamase
        fosBx1-fam       fosB                           FosBx1 family fosfomycin resistance bacillithiol transferase
        fosXCC           fosXCC                         fosfomycin resistance hydrolase FosXCC
        sal(D)           sal(D)                         ABC-F type ribosomal protection protein Sal(D)
        sal(E)           sal(E)                         ABC-F type ribosomal protection protein Sal(E)
        thfT             thfT                           reduced folate ECF transporter S component ThfT
        vanS-I           vanS-I                         VanI-type vancomycin resistance histidine kinase VanS
        vga(F)           vga(F)                         ABC-F type ribosomal protection protein Vga(F)
        vga(G)           vga(G)                         ABC-F type ribosomal protection protein Vga(G)
Hierarchy nodes removed
    core AMR AMR
        aadE-Cc          aadE-Cc NF033221.1             aminoglycoside 6-adenylyltransferase AadE-Cc
        lin              lin                            lmo0919 family lincomycin resistance ABC-F type ribosomal protection protein
    plus STRESS METAL
        nirA             nirA                           nickel resistance membrane nickel efflux protein NirA
Changed Hierarchy Nodes
    almG             glycine--lipid A transferase AlmG
        scope:           plus -> core
    blaASU1          ASU1 family class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaB3SU1         B3SU1 family subclass B3 metallo-beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaB3SU2         B3SU2 family subclass B3 metallo-beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaL2            L2 family extended-spectrum class A beta-lactamase
        name:            L2 family class A beta-lactamase -> L2 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    cfxA3            extended-spectrum class A beta-lactamase CfxA3
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    cfxA4            extended-spectrum class A beta-lactamase CfxA4
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    cfxA5            broad-spectrum class A beta-lactamase CfxA5
        subclass:        BETA-LACTAM -> CEPHALOSPORIN


----------------------------------------------------------------------
Changes included in 2022-12-19.1
----------------------------------------------------------------------

Overview:
    - -o / --organism "Klebsiella" option split to "Klebsiella_pneumoniae" and
      "Klebsiella_oxytoca"
    - -o / --organism "Neisseria" option split to "Neisseria_gonorrhoeae" and
      "Neisseria_meningitidis"
    - Berkholderia blaPEN gene symbol reform based on review of Poirel, et al.,
      2009 (see below for curator explanation)
    - Many refined phenotypes ("class" and "subclasses") based on curation of
      the literature
    - New Klebsiella, Pseudomonas, and Acinetobacter point mutations


NCBI has begun a restructuring of our handling of names for chromosomal class A
beta-lactamases in the genus Burkholderia in order to increase clarity and
better reflect usages in the literature that follow PMID: 19075063 (Poirel, et
al., 2009). The gene symbols PenA and PenB are not instantly recognizable as
beta-lactamases, since these have also been used for penicillin-binding
proteins in Neisseria, and are now replaced with blaPEN-A and blaPEN-B. New
HMMs resolve two subfamilies of blaPEN enzymes, from the Burkholderia cepacia
complex (blaPEN-bcc, including PEN-A through PEN-H) and the Burkholderia
pseudomallei complex (blaPEN-bpc, including PEN-I). Published allele
designations in the PEN-A and PEN-B families take the format blaPEN-A1,
blaPEN-B1, etc. We recommend using shorthand names that are capitalized and
with hyphens, "PEN-A1" instead of "PenA1" to more closely resemble the handling
of most other beta-lactamases.

The proposal from Poirel, et al., 2009 provided enzyme names divided by
species. In some cases, divisions between families are quite small, e.g. PEN-I
for B. pseudomallei and PEN-K for B. mallei, despite only five amino acid
differences between the suggested founding members those families. In general,
NCBI remains skeptical of the potential overuse of chromosomal beta-lactamase
names as proxies for species identification, in part because differences may be
small, protein family structure is unclear when it depends on small
differences, and new sequenced examples or changes to taxonomic assignments
could invalidate previous assignments. Currently, we are in the process of
adding more specific HMMs within the blaPEN-bcc or blaPEN-bpc complexes, as we
did for blaPEN-A and blaPEN-B, if the usage seems well-established, member
sequences abundant enough, and the separation from other families clear enough.
We are interested in hearing feedback from the community on this effort,
including the possibility of adding PEN-A (from Burkholderia multivorans) and
PEN-B (from Burkholderia cenocepacia) to the NCBI managed allele submission and
reservation system.

Summary:
   Total proteins: 7597
        Core proteins: 6499
        Plus proteins: 1097
   AMR proteins: 6548
   STRESS proteins: 236
   VIRULENCE proteins: 813
   PubMed references: 2619
   Point mutations: 1003
   Point mutation reference sequences: 177
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Clostridioides_difficile, Enterococcus_faecalis,
       Enterococcus_faecium, Escherichia, Klebsiella_oxytoca, Klebsiella_pneumoniae,
       Neisseria_gonorrhoeae, Neisseria_meningitidis, Pseudomonas_aeruginosa,
       Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius,
       Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 687

Updates since release 2022-10-11.2:
   Proteins added: 95
       Core proteins added: 87
       Plus proteins added: 8
   AMR proteins added: 89
   STRESS proteins added: 1
   VIRULENCE proteins added: 5
   Alleles added: 73
   PubMed references added: 29
   PubMed references removed: 2
   Point mutations added: 12
   Reference Gene Catalog entries changed: 353
   Hierarchy nodes added: 26
   Hierarchy nodes removed: 1
   Hierarchy nodes changed: 36

Added proteins
    core AMR AMR
        blaIII           NG_148591.1 WP_000497840.1     class A beta-lactamase BlaIII
        dfrA41           NG_148595.1 WP_004729503.1     trimethoprim-resistant dihydrofolate reductase DfrA41
        rox              NG_148600.1 WP_015031687.1     rifampin monooxygenase Rox
        dfrA40           NG_148594.1 WP_034702334.1     trimethoprim-resistant dihydrofolate reductase DfrA40
        dfrA45           NG_148596.1 WP_049581834.1     trimethoprim-resistant dihydrofolate reductase DfrA45
        blaPEN-N         NG_148592.1 WP_060005294.1     PEN-N family class A beta-lactamase
        nimG             NG_148598.1 WP_087312253.1     5-nitroimidazole reductase NimG
        msr(I)           NG_148597.1 WP_198462967.1     ABC-F type ribosomal protection protein Msr(I)
        sal(B)           NG_148601.1 WP_218688397.1     ABC-F type ribosomal protection protein Sal(B)
        sal(C)           NG_148602.1 WP_218702729.1     ABC-F type ribosomal protection protein Sal(C)
        vanP             NG_088565.1 WP_222891055.1     putative D-alanine--(R)-lactate ligase VanP
        vanS-P           NG_088566.1 WP_222891058.1     VanP-type vancomycin resistance histidine kinase VanS
        crxA             NG_148593.1 WP_262761957.1     CrxA family subclass B1 metallo-beta-lactamase
        nimK             NG_148599.1 WP_268871842.1     5-nitroimidazole reductase NimK
        blaACT-110       NG_148603.1 WP_250127581.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-110
        blaACT-111       NG_148604.1 WP_069720053.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-111
        blaACT-91        NG_148605.1 WP_268871843.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-91
        blaACT-92        NG_148606.1 WP_268871844.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-92
        blaACT-93        NG_148607.1 WP_039261009.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-93
        blaACT-94        NG_148608.1 WP_252029529.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-94
        blaADC-286       NG_148609.1 WP_268871845.1     extended-spectrum class C beta-lactamase ADC-286
        blaADC-287       NG_148610.1 WP_068613499.1     extended-spectrum class C beta-lactamase ADC-287
        blaADC-288       NG_148611.1 WP_104074874.1     extended-spectrum class C beta-lactamase ADC-288
        blaADC-289       NG_148612.1 WP_114270086.1     extended-spectrum class C beta-lactamase ADC-289
        blaADC-290       NG_148613.1 WP_268871846.1     extended-spectrum class C beta-lactamase ADC-290
        blaCMH-8         NG_148614.1 WP_268871847.1     class C beta-lactamase CMH-8
        blaCMY-182       NG_148615.1 WP_103283398.1     class C beta-lactamase CMY-182
        blaCMY-183       NG_148616.1 WP_048215094.1     class C beta-lactamase CMY-183
        blaCMY-184       NG_148617.1 WP_268871848.1     class C beta-lactamase CMY-184
        blaCTX-M-259     NG_088602.1 WP_263598085.1     extended-spectrum class A beta-lactamase CTX-M-259
        blaFOX-21        NG_148618.1 WP_042058462.1     cephalosporin-hydrolyzing class C beta-lactamase FOX-21
        blaGES-57        NG_148619.1 WP_268871850.1     class A beta-lactamase GES-57
        blaIMP-98        NG_148620.1 WP_268871851.1     subclass B1 metallo-beta-lactamase IMP-98
        blaKLUC-6        NG_148621.1 WP_268871852.1     extended-spectrum class A beta-lactamase KLUC-6
        blaKPC-145       NG_148622.1 WP_268871853.1     class A beta-lactamase KPC-145
        blaKPC-146       NG_148623.1 WP_268871854.1     carbapenem-hydrolyzing class A beta-lactamase KPC-146
        blaKPC-147       NG_148624.1 WP_268871855.1     carbapenem-hydrolyzing class A beta-lactamase KPC-147
        blaKPC-148       NG_148625.1 WP_264254632.1     class A beta-lactamase KPC-148
        blaKPC-151       NG_148626.1 WP_268871856.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-151
        blaKPC-153       NG_148627.1 WP_268871857.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-153
        blaMOX-18        NG_148628.1 WP_268871858.1     CMY-1/MOX family class C beta-lactamase MOX-18
        blaMOX-19        NG_148629.1 WP_268871859.1     CMY-1/MOX family class C beta-lactamase MOX-19
        blaMOX-20        NG_148630.1 WP_268871860.1     CMY-1/MOX family class C beta-lactamase MOX-20
        blaMOX-21        NG_148631.1 WP_268871861.1     CMY-1/MOX family class C beta-lactamase MOX-21
        blaMOX-22        NG_148632.1 WP_223915751.1     CMY-1/MOX family class C beta-lactamase MOX-22
        blaMOX-23        NG_148633.1 WP_180898621.1     CMY-1/MOX family class C beta-lactamase MOX-23
        blaMOX-24        NG_148634.1 WP_244054059.1     CMY-1/MOX family class C beta-lactamase MOX-24
        blaMOX-25        NG_148635.1 WP_128343957.1     CMY-1/MOX family class C beta-lactamase MOX-25
        blaNDM-45        NG_148636.1 WP_268871862.1     subclass B1 metallo-beta-lactamase NDM-45
        blaNDM-46        NG_148637.1 WP_268871863.1     subclass B1 metallo-beta-lactamase NDM-46
        blaNDM-47        NG_148638.1 WP_268871864.1     subclass B1 metallo-beta-lactamase NDM-47
        blaNDM-48        NG_148639.1 WP_268871865.1     subclass B1 metallo-beta-lactamase NDM-48
        blaOXA-1152      NG_148640.1 WP_150662373.1     OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1152
        blaOXA-1153      NG_148641.1 WP_134696937.1     class D beta-lactamase OXA-1153
        blaOXA-1154      NG_148642.1 WP_268871866.1     class D beta-lactamase OXA-1154
        blaOXA-1155      NG_148643.1 WP_268871867.1     class D beta-lactamase OXA-1155
        blaOXA-1156      NG_148644.1 WP_268871868.1     class D beta-lactamase OXA-1156
        blaOXA-1157      NG_148645.1 WP_268871869.1     OXA-12 family class D beta-lactamase OXA-1157
        blaOXA-1158      NG_148646.1 WP_268871870.1     class D beta-lactamase OXA-1158
        blaOXA-1159      NG_148647.1 WP_052815145.1     class D beta-lactamase OXA-1159
        blaOXA-1160      NG_148648.1 WP_010672256.1     class D beta-lactamase OXA-1160
        blaOXA-1161      NG_148649.1 WP_151027527.1     class D beta-lactamase OXA-1161
        blaOXA-1162      NG_148650.1 WP_139462269.1     OXA-12 family class D beta-lactamase OXA-1162
        blaOXA-1163      NG_148651.1 WP_042016119.1     class D beta-lactamase OXA-1163
        blaOXA-1164      NG_148652.1 WP_268871871.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1164
        blaOXA-1165      NG_148653.1 WP_268871872.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1165
        blaOXA-1166      NG_148654.1 WP_104074618.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1166
        blaOXA-1168      NG_148655.1 WP_268871873.1     OXA-10 family class D beta-lactamase OXA-1168
        blaOXA-1169      NG_148656.1 WP_268871874.1     OXA-10 family class D beta-lactamase OXA-1169
        blaOXA-1170      NG_148657.1 WP_268871875.1     OXA-10 family class D beta-lactamase OXA-1170
        blaOXA-1171      NG_148658.1 WP_268871876.1     OXA-10 family class D beta-lactamase OXA-1171
        blaOXA-1172      NG_148659.1 WP_268871877.1     OXA-2 family class D beta-lactamase OXA-1172
        blaOXA-1173      NG_148660.1 WP_268871878.1     OXA-2 family class D beta-lactamase OXA-1173
        blaOXA-1174      NG_148661.1 WP_057384527.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1174
        blaOXA-1175      NG_148662.1 WP_268871879.1     OXA-10 family class D beta-lactamase OXA-1175
        blaOXA-1176      NG_148663.1 WP_268871880.1     OXA-60 family carbapenem-hydrolyzing class D beta-lactamase OXA-1176
        blaOXA-1177      NG_148664.1 WP_268871881.1     OXA-22 family class D beta-lactamase OXA-1177
        blaOXA-1178      NG_148665.1 WP_268871882.1     OXA-58 family carbapenem-hydrolyzing class D beta-lactamase OXA-1178
        blaOXA-1183      NG_148666.1 WP_117407753.1     OXA-2 family class D beta-lactamase OXA-1183
        blaOXA-1184      NG_148667.1 WP_263096442.1     OXA-10 family class D beta-lactamase OXA-1184
        blaPDC-534       NG_148668.1 WP_268871884.1     class C beta-lactamase PDC-534
        blaPDC-535       NG_148669.1 WP_126590471.1     class C beta-lactamase PDC-535
        blaPDC-536       NG_148670.1 WP_268871885.1     class C beta-lactamase PDC-536
        blaPDC-537       NG_148671.1 WP_243210688.1     class C beta-lactamase PDC-537
        blaPFM-4         NG_148672.1 WP_198799270.1     subclass B2 metallo-beta-lactamase PFM-4
        blaSHV-230       NG_148673.1 WP_268871888.1     class A beta-lactamase SHV-230
        blaSHV-231       NG_148674.1 WP_268871889.1     class A beta-lactamase SHV-231
    plus AMR AMR
        cph              U13078.1 AAA92037.1            capreomycin phosphotransferase
        helR             FR845719.1 CCA59315.1          RNA polymerase recycling motor ATPase HelR
    plus STRESS HEAT
        clpK             KY887595.1 ASF80763.1          heat shock survival AAA family ATPase ClpK
    plus VIRULENCE VIRULENCE
        stxB2h           CP022279.1 AUM09787.1          Shiga toxin Stx2h subunit B
        stxA2h           CP022279.1 AUM09788.1          Shiga toxin Stx2h subunit A
        stxA2i           FN252457.1 CAX53241.1          Shiga toxin Stx2i subunit A
        stxB2i           FN252457.1 CAX53242.1          Shiga toxin Stx2i subunit B
        stxA2j           MZ571121.1 QZN05543.1          Shiga toxin Stx2j subunit A
Added point mutations
    core AMR POINT
        blaOXY_G-34A     CEPHALOSPORIN Klebsiella_oxytoca
        blaOXY_G-38T     CEPHALOSPORIN Klebsiella_oxytoca
        blaOXY_T-58A     CEPHALOSPORIN Klebsiella_oxytoca
        blaOXY_T-67C     CEPHALOSPORIN Klebsiella_oxytoca
        cirA_G75W        CEFIDEROCOL Klebsiella_pneumoniae
        cirA_W427STOP    CEFIDEROCOL Klebsiella_pneumoniae
        cirA_Y253CfsTer5 CEFIDEROCOL Klebsiella_pneumoniae
        oprD_W339STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_W65STOP     CARBAPENEM Pseudomonas_aeruginosa
        oprD_Y283STOP    CARBAPENEM Pseudomonas_aeruginosa
        pmrB_A226T       COLISTIN Acinetobacter_baumannii
        pmrC_R125P       COLISTIN Acinetobacter_baumannii
Changed reference gene catalog records
    kdeA ABR76310.1
        blacklisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    arsC BAA24824.1
        blacklisted_taxa: Escherichia, Klebsiella -> Escherichia, Klebsiella_oxytoca
    fieF BAB89353.1
        blacklisted_taxa: Klebsiella -> Klebsiella_oxytoca
    stxA2l CAP17609.1
        gene_family:     stxA2e -> stxA2l
        hierarchy_node:  stxA2e -> stxA2l
        product_name:    Shiga toxin Stx2e subunit A -> Shiga toxin Stx2l subunit A
        subclass:        STX2E -> STX2L
    cfr WP_001010505.1
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> <empty>
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMUTILIN
    spw WP_002294509.1
        curated_refseq_start: No -> Yes
        genbank_nucleotide_accession: AFQJ01000004.1 -> CP024781.1
        genbank_protein_accession: EGP12870.1 -> <empty>
        genbank_start:   648813 -> 1553414
        genbank_stop:    649622 -> 1554223
    pbp2 WP_003703066.1
        product_name:    Neisseria penicillin-binding protein PBP2 -> Neisseria gonorrhoeae penicillin-binding protein PBP2
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    nimE WP_005812773.1
        product_name:    nitroimidazole resistance protein NimE -> 5-nitroimidazole reductase NimE
    nimJ WP_005812825.1
        product_name:    nitroimidazole resistance protein NimJ -> 5-nitroimidazole reductase NimJ
    blaPEN-M WP_006027381.1
        gene_family:     blaPEN-bpc -> blaPEN-M
        hierarchy_node:  blaPEN-bpc -> blaPEN-M
        product_name:    PEN family class A beta-lactamase, Bpc-type -> PEN-M family class A beta-lactamase
    blaPEN-J WP_010108817.1
        product_name:    class A beta-lactamase PEN-J -> PEN-J family class A beta-lactamase
    tetB WP_011116970.1
        gene_family:     tetAB_B -> tetB
    rox WP_011210071.1
        hierarchy_node:  rox -> rox_nf
    nimI WP_021588763.1
        product_name:    nitroimidazole resistance protein NimI -> 5-nitroimidazole reductase NimI
    aac(6') WP_023417224.1
        genbank_nucleotide_accession: ASHF01000011.1 -> CP106650.1
        genbank_start:   464699 -> 2183753
        genbank_stop:    465181 -> 2184235
        refseq_nucleotide_accession: NG_052413.1 -> NG_148590.1
    blaPEN-L WP_025370306.1
        product_name:    class A beta-lactamase PEN-L -> PEN-L family class A beta-lactamase
    nimA WP_032488596.1
        product_name:    nitroimidazole resistance protein NimA -> 5-nitroimidazole reductase NimA
    cfr WP_032491462.1
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> <empty>
        pubmed_reference: <empty> -> 16801432
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> CLINDAMYCIN/LINEZOLID/PHENICOL/STREPTOGRAMIN/TIAMUTILIN
    mecA WP_057521704.1
        hierarchy_node:  mecA -> mecA-ceftar
        product_name:    PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -> ceftaroline-resistant PBP2a family peptidoglycan transpeptidase MecA
        pubmed_reference: <empty> -> 24777906
        subclass:        METHICILLIN -> CEFTAROLINE/METHICILLIN
        synonyms:        pbp2A -> <empty>
    mecA WP_063852670.1
        pubmed_reference: <empty> -> 24777906
        subclass:        METHICILLIN -> CEFTAROLINE/METHICILLIN
    mecA WP_063852677.1
        pubmed_reference: <empty> -> 24777906
        subclass:        METHICILLIN -> CEFTAROLINE/METHICILLIN
    mecA WP_063852683.1
        pubmed_reference: <empty> -> 24777906
        subclass:        METHICILLIN -> CEFTAROLINE/METHICILLIN
    nimB WP_063854490.1
        product_name:    nitroimidazole resistance protein NimB -> 5-nitroimidazole reductase NimB
    nimC WP_063854491.1
        product_name:    nitroimidazole resistance protein NimC -> 5-nitroimidazole reductase NimC
    nimD WP_063854492.1
        product_name:    nitroimidazole resistance protein NimD -> 5-nitroimidazole reductase NimD
    blaPEN-I WP_063854501.1
        product_name:    class A beta-lactamase PEN-I -> PEN-I family class A beta-lactamase
    sal(A) WP_063854920.1
        class:           LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN
    16S_C1191T NZ_AP019853.2
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    23S_A2045G NC_002946.2
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    23S_A2057G NC_002946.2
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    23S_A2145G NC_002946.2
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    23S_C2597T NC_002946.2
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    acrR_M109I WP_002892080.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
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        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaPDC-459 WP_197749408.1
        product_name:    class C beta-lactamase PDC-459 -> extended-spectrum class C beta-lactamase PDC-459
        pubmed_reference: <empty> -> 36073814
    blaPDC-460 WP_197749409.1
        product_name:    class C beta-lactamase PDC-460 -> extended-spectrum class C beta-lactamase PDC-460
        pubmed_reference: <empty> -> 36073814
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        product_name:    class C beta-lactamase PDC-461 -> extended-spectrum class C beta-lactamase PDC-461
        pubmed_reference: <empty> -> 36073814
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        product_name:    class C beta-lactamase PDC-462 -> extended-spectrum class C beta-lactamase PDC-462
        pubmed_reference: <empty> -> 36073814
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        product_name:    class C beta-lactamase PDC-463 -> extended-spectrum class C beta-lactamase PDC-463
        pubmed_reference: <empty> -> 36073814
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        product_name:    class C beta-lactamase PDC-464 -> extended-spectrum class C beta-lactamase PDC-464
        pubmed_reference: <empty> -> 36073814
    blaTEM-230 WP_104009854.1
        product_name:    class A beta-lactamase TEM-230 -> extended-spectrum class A beta-lactamase TEM-230
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    crrB_F84S WP_004184324.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    crrB_Y31H WP_004184324.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    gyrA_D87N WP_117036963.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
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        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
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        pubmed_reference: 10799008,7830580 -> 10799008
        whitelisted_taxa: Neisseria -> Neisseria_meningitidis
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        pubmed_reference: 10799008,7830580 -> 7830580
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
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        whitelisted_taxa: Neisseria -> Neisseria_meningitidis
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        whitelisted_taxa: Neisseria -> Neisseria_meningitidis
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        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
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        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
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        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
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        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
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        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
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        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    mtrR_A39T WP_047924300.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    mtrR_G-131A NZ_CP043871.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    mtrR_G45D WP_047924300.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    norM_A-7G NZ_AP023073.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    norM_C-104T NZ_AP023073.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    ompK35_E132K WP_004141771.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ompK35_W230STOP WP_004141771.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ompK36_D135DD WP_002913005.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ompK36_D135DGD WP_002913005.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ompK36_E78STOP WP_002913005.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ompK36_G133D WP_002913005.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ompK36_T126STOP WP_002913005.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ompK36_T136TDT WP_002913005.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ompK36_T192del WP_002913005.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ompK36_T261STOP WP_002913005.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ompK36_T333N WP_002913005.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ompK36_W125STOP WP_002913005.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    oqxR_D95E WP_000888203.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    oqxR_F6S WP_000888203.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    oqxR_Q11L WP_000888203.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    oqxR_V102G WP_000888203.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    oqxR_V113I WP_000888203.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    parC_D86N WP_010951227.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    parC_E84K WP_101982161.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    parC_E91G WP_010951227.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    parC_E91K WP_010951227.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    parC_S80I WP_101982161.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    parC_S87I WP_010951227.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    parC_S87N WP_010951227.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    parC_S87R WP_010951227.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    parC_S88P WP_010951227.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    parE_G410V WP_003691666.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_A311V WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_A501AA WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_A501P WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_A501T WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_A501V WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_A510V WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_A516G WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_D346DD WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_F504L WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_G542S WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_G545S WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_I312M WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_N512Y WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_P551L WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_P551S WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_T483S WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_V316P WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    penA_V316T WP_003693546.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    phoP_D191Y WP_004150807.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoP_I201N WP_004150807.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoP_V3F WP_004150807.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_A20P WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_A20S WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_D266DD WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_D438N WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_G385S WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_L26P WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_L348Q WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_L396Q WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_L96P WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_R16C WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_S174N WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    phoQ_S56R WP_004147969.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrA_G53C WP_002895659.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrA_G53S WP_002895659.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrA_S42N WP_002895659.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrB_ALNQLV129del WP_004179093.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrB_D313N WP_004179093.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrB_L17Q WP_004179093.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrB_L82R WP_004179093.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrB_R14del WP_004179093.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrB_R256G WP_004179093.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrB_S208N WP_004179093.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrB_S85R WP_004179093.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrB_T140P WP_004179093.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrB_T157P WP_004179093.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    pmrB_Y209del WP_004179093.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ponA_L421P WP_003687357.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    porB1b_A121D WP_106333382.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    porB1b_A121H WP_106333382.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    porB1b_A121N WP_106333382.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    porB1b_A121P WP_106333382.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    porB1b_G120D WP_106333382.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    porB1b_G120K WP_106333382.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    porB1b_G120P WP_106333382.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    porB1b_G120R WP_106333382.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    ramR_A16D WP_004176968.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ramR_A183D WP_004176968.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ramR_A19V WP_004176968.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ramR_I88N WP_004176968.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ramR_K5E WP_004176968.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ramR_T162I WP_004176968.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    ramR_T43M WP_004176968.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    rplD_G70D WP_003690088.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rplV_K83KKGPSLK WP_002215424.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rplV_K90KARAK WP_002215424.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rpoB_D543V WP_002225943.1
        whitelisted_taxa: Neisseria -> Neisseria_meningitidis
    rpoB_G158V WP_003690105.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rpoB_H553N WP_002225943.1
        whitelisted_taxa: Neisseria -> Neisseria_meningitidis
    rpoB_H553R WP_002225943.1
        whitelisted_taxa: Neisseria -> Neisseria_meningitidis
    rpoB_H553Y WP_002225943.1
        whitelisted_taxa: Neisseria -> Neisseria_meningitidis
    rpoB_P157L WP_003690105.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rpoB_R201H WP_003690105.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rpoB_S549F WP_002225943.1
        whitelisted_taxa: Neisseria -> Neisseria_meningitidis
    rpoB_S558F WP_002225943.1
        whitelisted_taxa: Neisseria -> Neisseria_meningitidis
    rpoD_DDDA92del WP_003688264.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rpoD_E98K WP_003688264.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rpsE_K28E WP_002215445.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rpsE_T24P WP_002215445.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rpsE_V27del WP_002215445.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rpsJ_V57L WP_001181005.1
        whitelisted_taxa: Klebsiella -> Klebsiella_pneumoniae
    rpsJ_V57L WP_002215394.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rpsJ_V57M WP_002215394.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae
    rpsJ_V57Q WP_002215394.1
        whitelisted_taxa: Neisseria -> Neisseria_gonorrhoeae

Hierarchy nodes added
    core AMR AMR
        bla-B1_long      bla NF041269.1                 subclass B1 metallo-beta-lactamase, long type
        blaIII           blaIII NF041270.1              class A beta-lactamase BlaIII
        blaPEN-M         blaPEN-M                       PEN-M family class A beta-lactamase
        blaPEN-N         blaPEN-N NF041253.1            PEN-N family class A beta-lactamase
        crxA             crxA                           CrxA family subclass B1 metallo-beta-lactamase
        dfrA40           dfrA40                         trimethoprim-resistant dihydrofolate reductase DfrA40
        dfrA41           dfrA41                         trimethoprim-resistant dihydrofolate reductase DfrA41
        dfrA45           dfrA45                         trimethoprim-resistant dihydrofolate reductase DfrA45
        msr(I)           msr(I)                         ABC-F type ribosomal protection protein Msr(I)
        nimG             nimG                           5-nitroimidazole reductase NimG
        nimK             nimK                           5-nitroimidazole reductase NimK
        rox_nf           rox                            rifampin monooxygenase Rox
        rox_sv           rox                            rifampin monooxygenase Rox
        sal(B)           sal(B)                         ABC-F type ribosomal protection protein Sal(B)
        sal(C)           sal(C)                         ABC-F type ribosomal protection protein Sal(C)
        vanP             vanP                           putative D-alanine--(R)-lactate ligase VanP
        vanS-P           vanS-P                         VanP-type vancomycin resistance histidine kinase VanS
    plus AMR AMR
        cph              cph NF041268.1                 capreomycin phosphotransferase
        helR             helR NF041254.1                RNA polymerase recycling motor ATPase HelR
    plus STRESS HEAT
        clpK             clpK NF033606.1                heat shock survival AAA family ATPase ClpK
    plus VIRULENCE VIRULENCE
        stxA2h           stxA2h                         Shiga toxin Stx2h subunit A
        stxA2i           stxA2i                         Shiga toxin Stx2i subunit A
        stxA2j           stxA2j                         Shiga toxin Stx2j subunit A
        stxA2l           stxA2l                         Shiga toxin Stx2l subunit A
        stxB2h           stxB2h                         Shiga toxin Stx2h subunit B
        stxB2i           stxB2i                         Shiga toxin Stx2i subunit B
Hierarchy nodes removed
    core AMR AMR
        rox              rox                            rifampin monooxygenase Rox
Changed Hierarchy Nodes
    blaOXA-213_fam   OXA-213 family carbapenem-hydrolyzing class D beta-lactamase
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-58_fam    OXA-58 family carbapenem-hydrolyzing class D beta-lactamase
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-5_fam     OXA-5 family class D beta-lactamase
        hmm_acc:         NF040527.1 -> NF040527.2
    blaOXY           OXY family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-1         OXY-1 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-10        OXY-10 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-11        OXY-11 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-12        OXY-12 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-2         OXY-2 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-3         OXY-3 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-4         OXY-4 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-5         OXY-5 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-6         OXY-6 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-7         OXY-7 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-8         OXY-8 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXY-9         OXY-9 family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaPEN-I         PEN-I family class A beta-lactamase
        name:            class A beta-lactamase PEN-I -> PEN-I family class A beta-lactamase
    blaPEN-J         PEN-J family class A beta-lactamase
        name:            class A beta-lactamase PEN-J -> PEN-J family class A beta-lactamase
    blaPEN-L         PEN-L family class A beta-lactamase
        name:            class A beta-lactamase PEN-L -> PEN-L family class A beta-lactamase
    cfr              23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr
        class:           LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/LINCOSAMIDE/OXAZOLIDINONES/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN -> PHENICOL/CLINDAMYCIN/LINEZOLID/TIAMUTILIN/STREPTOGRAMIN
    cmx_cmrA         Cmx/CmrA family chloramphenicol efflux MFS transporter
        symbol:          cmx_cmrA -> cml
    garos_AAA        garosamine-type aminoglycoside resistance ATP-binding protein
        symbol:          gar_fam -> gar
    mecA-ceftar      ceftaroline-resistant PBP2a family peptidoglycan transpeptidase MecA
        subclass:        METHICILLIN -> CEFTAROLINE/METHICILLIN
    nimA             5-nitroimidazole reductase NimA
        name:            nitroimidazole resistance protein NimA -> 5-nitroimidazole reductase NimA
    nimABCDEF        NimABCDEF family 5-nitroimidazole reductase
        name:            NimABCDEF family nitroimidazole resistance protein -> NimABCDEF family 5-nitroimidazole reductase
    nimB             5-nitroimidazole reductase NimB
        name:            nitroimidazole resistance protein NimB -> 5-nitroimidazole reductase NimB
    nimC             5-nitroimidazole reductase NimC
        name:            nitroimidazole resistance protein NimC -> 5-nitroimidazole reductase NimC
    nimD             5-nitroimidazole reductase NimD
        name:            nitroimidazole resistance protein NimD -> 5-nitroimidazole reductase NimD
    nimE             5-nitroimidazole reductase NimE
        name:            nitroimidazole resistance protein NimE -> 5-nitroimidazole reductase NimE
    nimI             5-nitroimidazole reductase NimI
        name:            nitroimidazole resistance protein NimI -> 5-nitroimidazole reductase NimI
    nimIJ            NimIJ family 5-nitroimidazole reductase
        name:            NimIJ family nitroimidazole resistance protein -> NimIJ family 5-nitroimidazole reductase
    nimJ             5-nitroimidazole reductase NimJ
        name:            nitroimidazole resistance protein NimJ -> 5-nitroimidazole reductase NimJ
    sal              Sal family ABC-F type ribosomal protection protein
        class:           LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN
        hmm_acc:         NF000169.1 -> NF000169.2
        subclass:        LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN
    sal(A)           ABC-F type ribosomal protection protein Sal(A)
        class:           LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN
        subclass:        LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/PLEUROMUTILIN/STREPTOGRAMIN
    tet(M-W-O-S)     TetM/TetW/TetO/TetS family tetracycline resistance ribosomal protection protein
        symbol:          tet_rib_protect -> tet
    tetAB_B          tetracycline efflux ABC transporter TetAB subunit B
        symbol:          tetAB_B -> tetB


----------------------------------------------------------------------
Changes included in 2022-10-11.2
----------------------------------------------------------------------

Overview:

 - Several changes to blaPEN family to bring the database contents and
   nomenclature to conform with Poirel 2009 (PMID:19075063) this work is not
   complete, but should be complete for the next release
 - Several HMM updates including 6 new HMMs and 2 updates to existing HMMs
 - Curators reviewed blaKPC phenotypes and made some updates
 - Reorganization of names of van genes to make them consistent with our AMR
   gene standards
 - Vibrio enterotoxin genes ctxA and ctxB added
 - WP_003410677.1 gene symbol was corrected to blaC to conform with other
   databases


Summary:
   Total proteins: 7502
        Core proteins: 6412
        Plus proteins: 1089
   AMR proteins: 6459
   STRESS proteins: 235
   VIRULENCE proteins: 808
   PubMed references: 2592
   Point mutations: 991
   Point mutation reference sequences: 173
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Clostridioides_difficile, Enterococcus_faecalis,
       Enterococcus_faecium, Escherichia, Klebsiella, Neisseria, Pseudomonas_aeruginosa,
       Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius,
       Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 681

Updates since release 2022-08-09.1:
   Proteins added: 128
       Core proteins added: 126
       Plus proteins added: 2
   AMR proteins added: 126
   VIRULENCE proteins added: 2
   Alleles added: 119
   PubMed references added: 7
   Reference Gene Catalog entries changed: 40
   Hierarchy nodes added: 22
   Hierarchy nodes removed: 3
   Hierarchy nodes changed: 18

Added proteins
    core AMR AMR
        blaMAB           NG_088376.1 WP_005091054.1     MAB family class A beta-lactamase
        blaPEN-F         NG_088378.1 WP_011659342.1     PEN-F family class A beta-lactamase
        blaPEN-E         NG_088377.1 WP_011882713.1     PEN-E family class A beta-lactamase
        mcr-3            NG_088379.1 WP_042649073.1     MCR-3-related phosphoethanolamine--lipid A transferase
        vanH-P           NG_088380.1 WP_222891054.1     D-lactate dehydrogenase VanH-P
        vanX-P           NG_088382.1 WP_222891056.1     D-Ala-D-Ala dipeptidase VanX-P
        vanR-P           NG_088381.1 WP_222891057.1     vancomycin resistance response regulator transcription factor VanR-P
        aac(6')-Iap      NG_088375.1 WP_262697082.1     aminoglycoside 6'-N-acetyltransferase AAC(6')-Iap
        blaADC-283       NG_081788.1 WP_257394578.1     extended-spectrum class C beta-lactamase ADC-283
        blaADC-284       NG_088383.1 WP_115434994.1     extended-spectrum class C beta-lactamase ADC-284
        blaADC-285       NG_088384.1 WP_262697121.1     extended-spectrum class C beta-lactamase ADC-285
        blaCTX-M-257     NG_088385.1 WP_262697122.1     extended-spectrum class A beta-lactamase CTX-M-257
        blaCTX-M-258     NG_088386.1 WP_262697123.1     extended-spectrum class A beta-lactamase CTX-M-258
        blaEBR-5         NG_088387.1 WP_260543444.1     subclass B1 metallo-beta-lactamase EBR-5
        blaFOX-20        NG_088388.1 WP_262697125.1     cephalosporin-hydrolyzing class C beta-lactamase FOX-20
        blaFRI-12        NG_081789.1 WP_257394579.1     carbapenem-hydrolyzing class A beta-lactamase FRI-12
        blaGES-56        NG_088389.1 WP_262697126.1     class A beta-lactamase GES-56
        blaGIM-3         NG_088390.1 WP_262697127.1     subclass B1 metallo-beta-lactamase GIM-3
        blaHMB-2         NG_088391.1 WP_079767532.1     subclass B1 metallo-beta-lactamase HMB-2
        blaIMP-97        NG_088392.1 WP_262697128.1     subclass B1 metallo-beta-lactamase IMP-97
        blaKBL-1         NG_088393.1 WP_137138291.1     class A beta-lactamase KBL-1
        blaKPC-101       NG_088394.1 WP_262697129.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-101
        blaKPC-110       NG_088395.1 WP_257394580.1     inhibitor-resistant class A beta-lactamase KPC-110
        blaKPC-111       NG_081791.1 WP_257394581.1     inhibitor-resistant class A beta-lactamase KPC-111
        blaKPC-134       NG_088396.1 WP_262697130.1     inhibitor-resistant class A beta-lactamase KPC-134
        blaKPC-135       NG_088397.1 WP_262697131.1     inhibitor-resistant class A beta-lactamase KPC-135
        blaKPC-138       NG_088398.1 WP_262697133.1     inhibitor-resistant extended-spectrum class A beta-lactamase KPC-138
        blaKPC-139       NG_088399.1 WP_262697134.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-139
        blaKPC-140       NG_088400.1 WP_262697135.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-140
        blaKPC-141       NG_088401.1 WP_262697136.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-141
        blaKPC-142       NG_088402.1 WP_262697137.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-142
        blaKPC-143       NG_088403.1 WP_262697138.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-143
        blaKPC-144       NG_088404.1 WP_262697139.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-144
        blaKPC-99        NG_088405.1 WP_262697140.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-99
        blaMIR-24        NG_088406.1 WP_087855277.1     cephalosporin-hydrolyzing class C beta-lactamase MIR-24
        blaMIR-25        NG_088407.1 WP_021240723.1     cephalosporin-hydrolyzing class C beta-lactamase MIR-25
        blaMOX-17        NG_088408.1 WP_262697141.1     CMY-1/MOX family class C beta-lactamase MOX-17
        blaNDM-44        NG_088409.1 WP_262697142.1     subclass B1 metallo-beta-lactamase NDM-44
        blaOXA-1140      NG_081792.1 WP_241469308.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1140
        blaOXA-1141      NG_081793.1 WP_257394582.1     OXA-10 family class D beta-lactamase OXA-1141
        blaOXA-1142      NG_081794.1 WP_257394583.1     class D beta-lactamase OXA-1142
        blaOXA-1143      NG_081795.1 WP_171865690.1     class D beta-lactamase OXA-1143
        blaOXA-1144      NG_081796.1 WP_046759755.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1144
        blaOXA-1145      NG_081797.1 WP_257394584.1     OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-1145
        blaOXA-1146      NG_088410.1 WP_262697143.1     OXA-48 family class D beta-lactamase OXA-1146
        blaOXA-1147      NG_088411.1 WP_262697144.1     OXA-10 family class D beta-lactamase OXA-1147
        blaOXA-1148      NG_088412.1 WP_262697145.1     OXA-10 family class D beta-lactamase OXA-1148
        blaOXA-1149      NG_088413.1 WP_150664304.1     OXA-62 family carbapenem-hydrolyzing class D beta-lactamase OXA-1149
        blaOXA-1150      NG_088414.1 WP_119685493.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1150
        blaOXA-1151      NG_088415.1 WP_262697150.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1151
        blaOXY-1-10      NG_088416.1 WP_049079240.1     extended-spectrum class A beta-lactamase OXY-1-10
        blaOXY-1-14      NG_088417.1 WP_088168768.1     extended-spectrum class A beta-lactamase OXY-1-14
        blaOXY-1-15      NG_088418.1 WP_119834461.1     extended-spectrum class A beta-lactamase OXY-1-15
        blaOXY-1-16      NG_088419.1 WP_160741710.1     extended-spectrum class A beta-lactamase OXY-1-16
        blaOXY-1-19      NG_088420.1 WP_196575333.1     extended-spectrum class A beta-lactamase OXY-1-19
        blaOXY-1-7       NG_088421.1 WP_102803085.1     extended-spectrum class A beta-lactamase OXY-1-7
        blaOXY-1-8       NG_088422.1 WP_032748514.1     extended-spectrum class A beta-lactamase OXY-1-8
        blaOXY-1-9       NG_088423.1 WP_064378351.1     extended-spectrum class A beta-lactamase OXY-1-9
        blaOXY-10-1      NG_088424.1 WP_110273168.1     extended-spectrum class A beta-lactamase OXY-10-1
        blaOXY-12-2      NG_088425.1 WP_182237112.1     extended-spectrum class A beta-lactamase OXY-12-2
        blaOXY-2-16      NG_088426.1 WP_023320486.1     extended-spectrum class A beta-lactamase OXY-2-16
        blaOXY-2-20      NG_088427.1 WP_163530110.1     extended-spectrum class A beta-lactamase OXY-2-20
        blaOXY-2-25      NG_088428.1 WP_097365603.1     extended-spectrum class A beta-lactamase OXY-2-25
        blaOXY-2-27      NG_088429.1 WP_196090373.1     extended-spectrum class A beta-lactamase OXY-2-27
        blaOXY-5-10      NG_088430.1 WP_186384957.1     extended-spectrum class A beta-lactamase OXY-5-10
        blaOXY-5-3       NG_088431.1 WP_049074725.1     extended-spectrum class A beta-lactamase OXY-5-3
        blaOXY-5-4       NG_088432.1 WP_004848499.1     extended-spectrum class A beta-lactamase OXY-5-4
        blaOXY-5-5       NG_088433.1 WP_109213213.1     extended-spectrum class A beta-lactamase OXY-5-5
        blaOXY-5-9       NG_088434.1 WP_182409324.1     extended-spectrum class A beta-lactamase OXY-5-9
        blaOXY-6-6       NG_088435.1 WP_049088977.1     extended-spectrum class A beta-lactamase OXY-6-6
        blaOXY-6-8       NG_088436.1 WP_154951884.1     extended-spectrum class A beta-lactamase OXY-6-8
        blaOXY-6-9       NG_088437.1 WP_155037090.1     extended-spectrum class A beta-lactamase OXY-6-9
        blaPDC-528       NG_081798.1 WP_136828312.1     class C beta-lactamase PDC-528
        blaPDC-529       NG_081799.1 WP_124129493.1     class C beta-lactamase PDC-529
        blaPDC-530       NG_081800.1 WP_257394585.1     class C beta-lactamase PDC-530
        blaPDC-531       NG_088438.1 WP_262697184.1     class C beta-lactamase PDC-531
        blaPDC-532       NG_088439.1 WP_262697185.1     class C beta-lactamase PDC-532
        blaPDC-533       NG_088440.1 WP_262697187.1     class C beta-lactamase PDC-533
        blaPEN-A1        NG_088441.1 WP_012216561.1     class A beta-lactamase PEN-A1
        blaPEN-A10       NG_088456.1 WP_105846710.1     class A beta-lactamase PEN-A10
        blaPEN-A11       NG_088457.1 WP_105777201.1     class A beta-lactamase PEN-A11
        blaPEN-A12       NG_088458.1 WP_105809721.1     class A beta-lactamase PEN-A12
        blaPEN-A13       NG_088459.1 WP_105766562.1     class A beta-lactamase PEN-A13
        blaPEN-A15       NG_088460.1 WP_107999608.1     class A beta-lactamase PEN-A15
        blaPEN-A16       NG_088461.1 WP_105825204.1     class A beta-lactamase PEN-A16
        blaPEN-A17       NG_088462.1 WP_105951298.1     class A beta-lactamase PEN-A17
        blaPEN-A18       NG_088463.1 WP_105835300.1     class A beta-lactamase PEN-A18
        blaPEN-A19       NG_088464.1 WP_105791036.1     class A beta-lactamase PEN-A19
        blaPEN-A2        NG_088465.1 WP_105796499.1     class A beta-lactamase PEN-A2
        blaPEN-A20       NG_088466.1 WP_088926609.1     class A beta-lactamase PEN-A20
        blaPEN-A21       NG_088467.1 WP_105841035.1     class A beta-lactamase PEN-A21
        blaPEN-A22       NG_088468.1 WP_105842598.1     class A beta-lactamase PEN-A22
        blaPEN-A23       NG_088469.1 WP_105782476.1     class A beta-lactamase PEN-A23
        blaPEN-A24       NG_088470.1 WP_105813799.1     class A beta-lactamase PEN-A24
        blaPEN-A25       NG_088471.1 WP_105854385.1     class A beta-lactamase PEN-A25
        blaPEN-A26       NG_088472.1 WP_105765688.1     class A beta-lactamase PEN-A26
        blaPEN-A27       NG_088473.1 WP_105765076.1     class A beta-lactamase PEN-A27
        blaPEN-A28       NG_088474.1 WP_088924033.1     class A beta-lactamase PEN-A28
        blaPEN-A29       NG_088475.1 WP_105792310.1     class A beta-lactamase PEN-A29
        blaPEN-A3        NG_088476.1 WP_105769622.1     class A beta-lactamase PEN-A3
        blaPEN-A30       NG_088477.1 WP_105807557.1     class A beta-lactamase PEN-A30
        blaPEN-A31       NG_088478.1 WP_039217008.1     class A beta-lactamase PEN-A31
        blaPEN-A32       NG_088479.1 WP_105762373.1     class A beta-lactamase PEN-A32
        blaPEN-A33       NG_088480.1 WP_069220914.1     class A beta-lactamase PEN-A33
        blaPEN-A34       NG_088481.1 WP_105856053.1     class A beta-lactamase PEN-A34
        blaPEN-A35       NG_088482.1 WP_105795180.1     class A beta-lactamase PEN-A35
        blaPEN-A37       NG_088483.1 WP_088929369.1     class A beta-lactamase PEN-A37
        blaPEN-A38       NG_088484.1 WP_105837729.1     class A beta-lactamase PEN-A38
        blaPEN-A4        NG_088485.1 WP_105781374.1     class A beta-lactamase PEN-A4
        blaPEN-A5        NG_088486.1 WP_105822028.1     class A beta-lactamase PEN-A5
        blaPEN-A6        NG_088487.1 WP_105803562.1     class A beta-lactamase PEN-A6
        blaPEN-A7        NG_088488.1 WP_105758546.1     class A beta-lactamase PEN-A7
        blaPEN-A8        NG_088489.1 WP_048804470.1     class A beta-lactamase PEN-A8
        blaPEN-A9        NG_088490.1 WP_105772526.1     class A beta-lactamase PEN-A9
        blaPEN-B1        NG_088442.1 WP_109342732.1     class A beta-lactamase PEN-B1
        blaPEN-B2        NG_088443.1 WP_262697188.1     class A beta-lactamase PEN-B2
        blaPEN-B3        NG_088444.1 WP_262697189.1     class A beta-lactamase PEN-B3
        blaPEN-B4        NG_088445.1 WP_163122236.1     class A beta-lactamase PEN-B4
        blaRAD-1         NG_088446.1 WP_004919358.1     carbapenem-hydrolyzing class D beta-lactamase RAD-1
        blaTEM-248       NG_088447.1 WP_262697192.1     class A beta-lactamase TEM-248
        blaTEM-249       NG_088448.1 WP_262697193.1     class A beta-lactamase TEM-249
        blaVEB-31        NG_088449.1 WP_262697194.1     extended-spectrum class A beta-lactamase VEB-31
        blaVIM-82        NG_088450.1 WP_238839790.1     subclass B1 metallo-beta-lactamase VIM-82
        blaVIM-83        NG_088451.1 WP_262697195.1     subclass B1 metallo-beta-lactamase VIM-83
        mcr-3.42         NG_088452.1 WP_257697591.1     phosphoethanolamine--lipid A transferase MCR-3.42
        mcr-4.7          NG_088453.1 WP_223106954.1     phosphoethanolamine--lipid A transferase MCR-4.7
    plus VIRULENCE VIRULENCE
        ctxB             AE003852.1 AAF94613.1          cholera enterotoxin binding subunit CtxB
        ctxA             AE003852.1 AAF94614.1          cholera enterotoxin catalytic subunit CtxA
Changed reference gene catalog records
    blaEC-5 AY899338.1
        genbank_nucleotide_accession: AY899338.1 -> DQ092424.1
        genbank_protein_accession: AAW82909.1 -> AAZ85965.1
        genbank_start: 110 -> 185
        genbank_stop: 1243 -> 1318
    scn ADL23798.1
        genbank_nucleotide_accession: CP002114.2 -> CP002114.3
        genbank_start:   2037898 -> 2043933
        genbank_stop:    2038248 -> 2044283
    vanR-Cd AXB64454.1
        product_name:    VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcriptoin factor VanR-G-Cd
    vanR-A WP_001280781.1
        product_name:    VanA-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-A
    vanR-B WP_002317273.1
        product_name:    VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B
    vanR-B WP_002368697.1
        product_name:    VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B
    vanR-C WP_003126775.1
        product_name:    VanC-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-C
    blaC WP_003410677.1
        gene_family:     blaA -> blaC
        hierarchy_node:  blaA_Mtub -> blaC
        product_name:    class A beta-lactamase BlaA -> class A beta-lactamase BlaC
    vanR-C WP_005228837.1
        product_name:    VanC-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-C
    blaPEN-bpc WP_006027381.1
        gene_family:     penI -> blaPEN-bpc
        hierarchy_node:  penI_Bp -> blaPEN-bpc
        product_name:    PenI family extended-spectrum class A beta-lactamase -> PEN family class A beta-lactamase, Bpc-type
    blaPEN-J WP_010108817.1
        gene_family:     penI -> blaPEN-J
        hierarchy_node:  penI_Bp -> blaPEN-J
        product_name:    PenI family extended-spectrum class A beta-lactamase -> class A beta-lactamase PEN-J
    vanR-Sc WP_011029105.1
        product_name:    VanSc-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-Sc
    vanR-I WP_011461303.1
        product_name:    VanI-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-I
    vanR-D WP_016295750.1
        product_name:    VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D
    vanR-G WP_021418928.1
        product_name:    VanG-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-G
    vanR-D WP_023042613.1
        product_name:    VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D
    vanR-D WP_023043165.1
        product_name:    VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D
    blaPEN-L WP_025370306.1
        gene_family:     penI -> blaPEN-L
        hierarchy_node:  penI_Bp -> blaPEN-L
        product_name:    PenI family extended-spectrum class A beta-lactamase -> class A beta-lactamase PEN-L
    blaPEN-bcc WP_027789588.1
        gene_family:     penA -> blaPEN-bcc
        hierarchy_node:  penA-A_Burk -> blaPEN-bcc
        product_name:    PenA family class A beta-lactamase -> PEN family class A beta-lactamase, Bcc-type
    vanR-B WP_032489743.1
        product_name:    VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B
    vanR-C WP_034872470.1
        product_name:    VanC-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-C
    aadA27 WP_050041693.1
        genbank_nucleotide_accession: LN873256.1 -> CP082146.1
        genbank_protein_accession: CTQ57092.1 -> UVB02487.1
    blaPEN-I WP_063854501.1
        gene_family:     penI -> blaPEN-I
        hierarchy_node:  penI_Bp -> blaPEN-I
        product_name:    PenI family extended-spectrum class A beta-lactamase -> class A beta-lactamase PEN-I
    vanR-D WP_063856715.1
        product_name:    VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D
    vanR-A WP_063856716.1
        product_name:    VanA-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-A
    vanR-E WP_063856718.1
        product_name:    VanE-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-E
    vanR-B WP_063856719.1
        product_name:    VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B
    vanR-A WP_063856720.1
        product_name:    VanA-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-A
    vanR-A WP_063856721.1
        product_name:    VanA-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-A
    vanR-D WP_063856722.1
        product_name:    VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D
    vanR-B WP_063856723.1
        product_name:    VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B
    vanR-L WP_063856724.1
        product_name:    VanL-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-L
    vanR-C WP_063856725.1
        product_name:    VanC-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-C
    vanR-D WP_063856727.1
        product_name:    VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D
    vanR-N WP_063856728.1
        product_name:    VanN-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-N
    vanR-O WP_063856729.1
        product_name:    VanO-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-O
    blaKPC-44 WP_140423311.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-44 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-44
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-86 WP_213994592.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-86 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-86
        pubmed_reference: <empty> -> 36003991
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-87 WP_213994593.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-87 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-87
        pubmed_reference: <empty> -> 36003991
    blaKPC-88 WP_213994594.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-88 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-88
        pubmed_reference: <empty> -> 36003991
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaPAM-2 WP_173179784.1
        pubmed_reference: 33577996 -> 33577996,35786775

Hierarchy nodes added
    core AMR AMR
        aac(6')-Iap      aac(6')-Iap                    aminoglycoside 6'-N-acetyltransferase AAC(6')-Iap
        blaC             blaC NF041154.1                class A beta-lactamase BlaC
        blaKBL           blaKBL NF041189.1              KBL family class A beta-lactamase
        blaMAB           blaMAB NF041113.1              MAB family class A beta-lactamase
        blaOXY-10        blaOXY                         OXY-10 family extended-spectrum class A beta-lactamase
        blaPEN           blaPEN                         PEN family class A beta-lactamase
        blaPEN-A         blaPEN-A NF041143.1            PEN-A family class A beta-lactamase
        blaPEN-B         blaPEN-B NF041138.1            PEN-B family class A beta-lactamase
        blaPEN-E         blaPEN-E                       PEN-E family class A beta-lactamase
        blaPEN-F         blaPEN-F                       PEN-F family class A beta-lactamase
        blaPEN-I         blaPEN-I                       class A beta-lactamase PEN-I
        blaPEN-J         blaPEN-J                       class A beta-lactamase PEN-J
        blaPEN-L         blaPEN-L                       class A beta-lactamase PEN-L
        blaPEN-bcc       blaPEN-bcc NF000320.3          PEN family class A beta-lactamase, Bcc-type
        blaPEN-bpc       blaPEN-bpc NF000321.3          PEN family class A beta-lactamase, Bpc-type
        blaRAD           blaRAD NF041187.1              RAD family carbapenem-hydrolyzing class D beta-lactamase
        vanH-P           vanH-P                         D-lactate dehydrogenase VanH-P
        vanR-P           vanR-P                         vancomycin resistance response regulator transcription factor VanR-P
        vanX-P           vanX-P                         D-Ala-D-Ala dipeptidase VanX-P
    non-reported VIRULENCE VIRULENCE
        VIRULENCE_Vchol
    plus VIRULENCE VIRULENCE
        ctxA             ctxA                           cholera enterotoxin catalytic subunit CtxA
        ctxB             ctxB                           cholera enterotoxin binding subunit CtxB
Hierarchy nodes removed
    core AMR AMR
        blaA_Mtub        blaA                           class A beta-lactamase BlaA
        penA-A_Burk      penA NF000320.2                PenA family class A beta-lactamase
        penI_Bp          penI NF000321.2                PenI family extended-spectrum class A beta-lactamase
Changed Hierarchy Nodes
    blaEBR           EBR family subclass B1 metallo-beta-lactamase
        hmm_acc:         NF000444.2 -> NF000444.3
    blaGIM           GIM family subclass B1 metallo-beta-lactamase
        hmm_acc:         NF000396.2 -> NF000396.3
    blaHMB           HMB family subclass B1 metallo-beta-lactamase
        hmm_acc:         <empty> -> NF041161.1
    blaSPR           SPR family subclass B3 metallo-beta-lactamase
        name:            SPR family putative metallo-beta-lactamase -> SPR family subclass B3 metallo-beta-lactamase
    mcr-3_set        MCR-3-related phosphoethanolamine--lipid A transferase
        name:            MCR-3 family phosphoethanolamine--lipid A transferase -> MCR-3-related phosphoethanolamine--lipid A transferase
    vanR-A           vancomycin resistance response regulator transcription factor VanR-A
        name:            VanA-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-A
    vanR-B           vancomycin resistance response regulator transcription factor VanR-B
        name:            VanB-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-B
    vanR-C           vancomycin resistance response regulator transcription factor VanR-C
        name:            VanC-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-C
    vanR-Cd          vancomycin resistance response regulator transcriptoin factor VanR-G-Cd
        name:            VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcriptoin factor VanR-G-Cd
    vanR-D           vancomycin resistance response regulator transcription factor VanR-D
        name:            VanD-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-D
    vanR-E           vancomycin resistance response regulator transcription factor VanR-E
        name:            VanE-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-E
    vanR-FM          vancomycin resistance response regulator transcription factor VanR-FM
        name:            VanR-FM family response regulator transcription factor -> vancomycin resistance response regulator transcription factor VanR-FM
    vanR-G           vancomycin resistance response regulator transcription factor VanR-G
        name:            VanG-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-G
    vanR-I           vancomycin resistance response regulator transcription factor VanR-I
        name:            VanI-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-I
    vanR-L           vancomycin resistance response regulator transcription factor VanR-L
        name:            VanL-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-L
    vanR-N           vancomycin resistance response regulator transcription factor VanR-N
        name:            VanN-type vancomycin resistance DNA-binding response regulator VanR -> vancomycin resistance response regulator transcription factor VanR-N
    vanR-O           vancomycin resistance response regulator transcription factor VanR-O
        name:            VanO-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-O
    vanR-Sc          vancomycin resistance response regulator transcription factor VanR-Sc
        name:            VanSc-type vancomycin resistance response regulator transcription factor VanR -> vancomycin resistance response regulator transcription factor VanR-Sc
----------------------------------------------------------------------
Changes included in 2022-08-09.1
----------------------------------------------------------------------

Overview:

- Curators reviewed and added point mutations for new organisms Burkholderia
  cepacia complex and Burkholderia pseudomallei complex
- New point mutations for Neisseria, E. coli, Campylobacter, and Acinetobacter.
- Several new hierarchy nodes for new families and new subfamilies including two
  new beta-lactamase families and two new erm families.
- Several new blaOXY genes and families stemming from a review of blaOXY
  nomenclature hosted at the Pasteur Institute.
- Several new beta-lacatamase HMMs for small beta-lactamase families.
- Additional PubMed references for some point mutations reexamined by curators.
  This led to changes in class and subclass for some parE and ompF mutations.

Summary:
   Total proteins: 7374
        Core proteins: 6286
        Plus proteins: 1087
   AMR proteins: 6333
   STRESS proteins: 235
   VIRULENCE proteins: 806
   PubMed references: 2586
   Point mutations: 991
   Point mutation reference sequences: 173
   Point mutation organism groups:
       Acinetobacter_baumannii, Burkholderia_cepacia, Burkholderia_pseudomallei,
       Campylobacter, Clostridioides_difficile, Enterococcus_faecalis,
       Enterococcus_faecium, Escherichia, Klebsiella, Neisseria, Pseudomonas_aeruginosa,
       Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius,
       Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 674

Updates since release 2022-05-26.1:
   Proteins added: 115
       Core proteins added: 115
       Plus proteins added: 0
   AMR proteins added: 115
   Alleles added: 108
   PubMed references added: 78
   Point mutations added: 49
   Reference Gene Catalog entries changed: 18
   Hierarchy nodes added: 13
   Hierarchy nodes changed: 5

Added proteins
    core AMR AMR
        erm(54)          NG_081669.1 WP_031885508.1     23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(54)
        lnu(H)           NG_081670.1 WP_051021433.1     lincosamide nucleotidyltransferase Lnu(H)
        mef(H)           NG_081672.1 WP_070509550.1     macrolide efflux MFS transporter Mef(H)
        poxtA-Ef         NG_081674.1 WP_094899500.1     ABC-F type ribosomal protection protein PoxtA-Ef
        erm(53)          NG_081668.1 WP_139847607.1     23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(53)
        mef(J)           NG_081673.1 WP_198462968.1     macrolide efflux MFS transporter Mef(J)
        blaACT-109       NG_081676.1 WP_063157039.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-109
        blaADC-267       NG_081677.1 WP_256875591.1     extended-spectrum class C beta-lactamase ADC-267
        blaADC-268       NG_081678.1 WP_105922788.1     extended-spectrum class C beta-lactamase ADC-268
        blaADC-269       NG_081679.1 WP_032025626.1     extended-spectrum class C beta-lactamase ADC-269
        blaADC-270       NG_081680.1 WP_199947622.1     extended-spectrum class C beta-lactamase ADC-270
        blaADC-271       NG_081681.1 WP_247791718.1     extended-spectrum class C beta-lactamase ADC-271
        blaADC-272       NG_081682.1 WP_256875592.1     extended-spectrum class C beta-lactamase ADC-272
        blaADC-273       NG_081683.1 WP_256875593.1     extended-spectrum class C beta-lactamase ADC-273
        blaADC-274       NG_081684.1 WP_256875594.1     extended-spectrum class C beta-lactamase ADC-274
        blaADC-275       NG_081685.1 WP_256875595.1     extended-spectrum class C beta-lactamase ADC-275
        blaADC-276       NG_081686.1 WP_256875596.1     extended-spectrum class C beta-lactamase ADC-276
        blaADC-277       NG_081687.1 WP_256875597.1     extended-spectrum class C beta-lactamase ADC-277
        blaADC-278       NG_081688.1 WP_118978092.1     extended-spectrum class C beta-lactamase ADC-278
        blaADC-279       NG_081689.1 WP_038343177.1     extended-spectrum class C beta-lactamase ADC-279
        blaADC-280       NG_081690.1 WP_078202643.1     extended-spectrum class C beta-lactamase ADC-280
        blaADC-281       NG_081691.1 WP_256875598.1     extended-spectrum class C beta-lactamase ADC-281
        blaADC-282       NG_081692.1 WP_256875599.1     extended-spectrum class C beta-lactamase ADC-282
        blaCMY-178       NG_081693.1 WP_256875600.1     class C beta-lactamase CMY-178
        blaCMY-181       NG_081780.1 WP_134216345.1     class C beta-lactamase CMY-181
        blaCTX-M-253     NG_081694.1 WP_256875601.1     extended-spectrum class A beta-lactamase CTX-M-253
        blaCTX-M-254     NG_081695.1 WP_256875602.1     extended-spectrum class A beta-lactamase CTX-M-254
        blaCTX-M-255     NG_081696.1 WP_254205601.1     extended-spectrum class A beta-lactamase CTX-M-255
        blaCTX-M-256     NG_081781.1 WP_257102135.1     extended-spectrum class A beta-lactamase CTX-M-256
        blaFONA-7        NG_081697.1 WP_098931096.1     class A beta-lactamase FONA-7
        blaGES-54        NG_081003.1 WP_250115625.1     carbapenem-hydrolyzing class A beta-lactamase GES-54
        blaGES-55        NG_081782.1 WP_257102136.1     class A beta-lactamase GES-55
        blaGOB-53        NG_081698.1 WP_256875603.1     subclass B3 metallo-beta-lactamase GOB-53
        blaKPC-100       NG_081070.1 WP_250200322.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-100
        blaKPC-127       NG_081071.1 WP_250200323.1     carbapenem-hydrolyzing class A beta-lactamase KPC-127
        blaKPC-128       NG_081072.1 WP_250200324.1     carbapenem-hydrolyzing class A beta-lactamase KPC-128
        blaKPC-130       NG_081699.1 WP_253892094.1     class A beta-lactamase KPC-130
        blaKPC-131       NG_081700.1 WP_256875604.1     carbapenem-hydrolyzing class A beta-lactamase KPC-131
        blaKPC-132       NG_081783.1 WP_257102137.1     inhibitor-resistant class A beta-lactamase KPC-132
        blaKPC-133       NG_081784.1 WP_257102138.1     carbapenem-hydrolyzing class A beta-lactamase KPC-133
        blaNDM-43        NG_081701.1 WP_256875605.1     subclass B1 metallo-beta-lactamase NDM-43
        blaNWM-1         NG_081702.1 WP_256875606.1     subclass B3 metallo-beta-lactamase NWM-1
        blaOXA-1052      NG_081703.1 WP_256875607.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1052
        blaOXA-1087      NG_081704.1 WP_256875608.1     OXA-10 family class D beta-lactamase OXA-1087
        blaOXA-1119      NG_081705.1 WP_256875609.1     OXA-48 family class D beta-lactamase OXA-1119
        blaOXA-1120      NG_081706.1 WP_256875610.1     OXA-10 family class D beta-lactamase OXA-1120
        blaOXA-1121      NG_081707.1 WP_256875611.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1121
        blaOXA-1122      NG_081708.1 WP_256875612.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1122
        blaOXA-1123      NG_081709.1 WP_256875613.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1123
        blaOXA-1124      NG_081710.1 WP_124125861.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1124
        blaOXA-1125      NG_081711.1 WP_033955867.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1125
        blaOXA-1126      NG_081712.1 WP_256875614.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1126
        blaOXA-1127      NG_081713.1 WP_023122435.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1127
        blaOXA-1128      NG_081714.1 WP_256875615.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1128
        blaOXA-1129      NG_081715.1 WP_057387633.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1129
        blaOXA-1130      NG_081716.1 WP_256875616.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1130
        blaOXA-1131      NG_081717.1 WP_126622689.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1131
        blaOXA-1132      NG_081718.1 WP_058017838.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1132
        blaOXA-1133      NG_081719.1 WP_033968246.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1133
        blaOXA-1134      NG_081720.1 WP_256875617.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1134
        blaOXA-1135      NG_081721.1 WP_033978625.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1135
        blaOXA-1136      NG_081722.1 WP_256875618.1     OXA-2 family class D beta-lactamase OXA-1136
        blaOXA-1137      NG_081723.1 WP_256875619.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1137
        blaOXA-1138      NG_081724.1 WP_256875620.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1138
        blaOXA-1139      NG_081725.1 WP_256875621.1     OXA-143 family carbapenem-hydrolyzing class D beta-lactamase OXA-1139
        blaOXA-944       NG_081726.1 WP_256875622.1     OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-944
        blaOXY-1-11      NG_081727.1 WP_049082137.1     extended-spectrum class A beta-lactamase OXY-1-11
        blaOXY-1-12      NG_081728.1 WP_057174064.1     extended-spectrum class A beta-lactamase OXY-1-12
        blaOXY-1-13      NG_081729.1 WP_080528555.1     extended-spectrum class A beta-lactamase OXY-1-13
        blaOXY-1-17      NG_081730.1 WP_162121893.1     extended-spectrum class A beta-lactamase OXY-1-17
        blaOXY-1-18      NG_081731.1 WP_185219566.1     extended-spectrum class A beta-lactamase OXY-1-18
        blaOXY-11-1      NG_081732.1 WP_154679523.1     extended-spectrum class A beta-lactamase OXY-11-1
        blaOXY-12-1      NG_081733.1 WP_181483194.1     extended-spectrum class A beta-lactamase OXY-12-1
        blaOXY-2-17      NG_081734.1 WP_256875623.1     extended-spectrum class A beta-lactamase OXY-2-17
        blaOXY-2-18      NG_081735.1 WP_064396914.1     extended-spectrum class A beta-lactamase OXY-2-18
        blaOXY-2-19      NG_081736.1 WP_256875624.1     extended-spectrum class A beta-lactamase OXY-2-19
        blaOXY-2-21      NG_081737.1 WP_049127974.1     extended-spectrum class A beta-lactamase OXY-2-21
        blaOXY-2-22      NG_081738.1 WP_064344965.1     extended-spectrum class A beta-lactamase OXY-2-22
        blaOXY-2-23      NG_081739.1 WP_064361275.1     extended-spectrum class A beta-lactamase OXY-2-23
        blaOXY-2-24      NG_081740.1 WP_064375196.1     extended-spectrum class A beta-lactamase OXY-2-24
        blaOXY-2-26      NG_081741.1 WP_126488681.1     extended-spectrum class A beta-lactamase OXY-2-26
        blaOXY-2-28      NG_081742.1 WP_256875625.1     extended-spectrum class A beta-lactamase OXY-2-28
        blaOXY-2-30      NG_081743.1 WP_241700785.1     extended-spectrum class A beta-lactamase OXY-2-30
        blaOXY-3-2       NG_081744.1 WP_142464024.1     extended-spectrum class A beta-lactamase OXY-3-2
        blaOXY-3-3       NG_081745.1 WP_142981135.1     extended-spectrum class A beta-lactamase OXY-3-3
        blaOXY-4-2       NG_081746.1 WP_142446236.1     extended-spectrum class A beta-lactamase OXY-4-2
        blaOXY-4-3       NG_081747.1 WP_142467842.1     extended-spectrum class A beta-lactamase OXY-4-3
        blaOXY-4-4       NG_081748.1 WP_142471056.1     extended-spectrum class A beta-lactamase OXY-4-4
        blaOXY-4-5       NG_081749.1 WP_142481206.1     extended-spectrum class A beta-lactamase OXY-4-5
        blaOXY-5-11      NG_081750.1 WP_197663517.1     extended-spectrum class A beta-lactamase OXY-5-11
        blaOXY-5-6       NG_081751.1 WP_177340503.1     extended-spectrum class A beta-lactamase OXY-5-6
        blaOXY-5-7       NG_081752.1 WP_181251167.1     extended-spectrum class A beta-lactamase OXY-5-7
        blaOXY-5-8       NG_081753.1 WP_182012076.1     extended-spectrum class A beta-lactamase OXY-5-8
        blaOXY-6-10      NG_081754.1 WP_181246811.1     extended-spectrum class A beta-lactamase OXY-6-10
        blaOXY-6-11      NG_081755.1 WP_181511480.1     extended-spectrum class A beta-lactamase OXY-6-11
        blaOXY-6-5       NG_081756.1 WP_024358907.1     extended-spectrum class A beta-lactamase OXY-6-5
        blaOXY-6-7       NG_081757.1 WP_098066351.1     extended-spectrum class A beta-lactamase OXY-6-7
        blaOXY-7-1       NG_081758.1 WP_256875626.1     extended-spectrum class A beta-lactamase OXY-7-1
        blaOXY-8-1       NG_081759.1 WP_112215366.1     extended-spectrum class A beta-lactamase OXY-8-1
        blaOXY-8-2       NG_081760.1 WP_142515482.1     extended-spectrum class A beta-lactamase OXY-8-2
        blaOXY-8-3       NG_081761.1 WP_142512117.1     extended-spectrum class A beta-lactamase OXY-8-3
        blaOXY-9-1       NG_081762.1 WP_142465578.1     extended-spectrum class A beta-lactamase OXY-9-1
        blaPAM-3         NG_081763.1 WP_111263186.1     subclass B3 metallo-beta-lactamase PAM-3
        blaPDC-519       NG_081764.1 WP_256875627.1     class C beta-lactamase PDC-519
        blaPDC-520       NG_081765.1 WP_256875628.1     class C beta-lactamase PDC-520
        blaPDC-521       NG_081766.1 WP_256875629.1     class C beta-lactamase PDC-521
        blaPDC-522       NG_081767.1 WP_256875630.1     class C beta-lactamase PDC-522
        blaPDC-523       NG_081768.1 WP_256875631.1     class C beta-lactamase PDC-523
        blaPDC-524       NG_081769.1 WP_256875632.1     class C beta-lactamase PDC-524
        blaPDC-525       NG_081770.1 WP_256875633.1     class C beta-lactamase PDC-525
        blaPDC-526       NG_081771.1 WP_121128759.1     class C beta-lactamase PDC-526
        blaPDC-527       NG_081772.1 WP_256875634.1     class C beta-lactamase PDC-527
        blaSIE-1         NG_081773.1 WP_007683232.1     subclass B3 metallo-beta-lactamase SIE-1
        blaTEM-247       NG_081774.1 WP_256875635.1     class A beta-lactamase TEM-247
    core AMR AMR-SUSCEPTIBLE
        pbp2              WP_003703066.1                Neisseria penicillin-binding protein PBP2
Added point mutations
    core AMR POINT
        adeL_G27R        TIGECYCLINE Acinetobacter_baumannii
        adeS_F12S        TIGECYCLINE Acinetobacter_baumannii
        ampD_A18E        CEPHALOSPORIN Burkholderia_cepacia
        ampD_F191C       CEPHALOSPORIN Burkholderia_cepacia
        ampD_H68Y        CEPHALOSPORIN Burkholderia_cepacia
        ampD_H74P        CEPHALOSPORIN Burkholderia_cepacia
        ampD_I121S       CEPHALOSPORIN Burkholderia_cepacia
        ampD_L37F        CEPHALOSPORIN Burkholderia_cepacia
        ampD_L63P        CEPHALOSPORIN Burkholderia_cepacia
        ampD_L75P        CEPHALOSPORIN Burkholderia_cepacia
        ampD_P46T        CEPHALOSPORIN Burkholderia_cepacia
        ampD_R167S       CEPHALOSPORIN Burkholderia_cepacia
        ampD_R79G        CEPHALOSPORIN Burkholderia_cepacia
        ampD_S120L       CEPHALOSPORIN Burkholderia_cepacia
        ampD_S44G        CEPHALOSPORIN Burkholderia_cepacia
        ampD_S81P        CEPHALOSPORIN Burkholderia_cepacia
        ampD_V39A        CEPHALOSPORIN Burkholderia_cepacia
        amrR_A47T        CARBAPENEM Burkholderia_pseudomallei
        amrR_ASLD153del  CARBAPENEM Burkholderia_pseudomallei
        amrR_E190STOP    CARBAPENEM Burkholderia_pseudomallei
        amrR_E21D        CARBAPENEM Burkholderia_pseudomallei
        amrR_G30D        CARBAPENEM Burkholderia_pseudomallei
        amrR_L132P       CARBAPENEM Burkholderia_pseudomallei
        amrR_L142P       AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN Burkholderia_cepacia
        amrR_S166P       CARBAPENEM Burkholderia_pseudomallei
        amrR_S174P       CHLORAMPHENICOL/MEROPENEM/QUINOLONE Burkholderia_cepacia
        amrR_VAVC60del   CARBAPENEM Burkholderia_pseudomallei
        bpeR_D176A       CARBAPENEM Burkholderia_pseudomallei
        dut_G91A         TRIMETHOPRIM-SULFAMETHOXAZOLE Burkholderia_pseudomallei
        gyrA_D87H        QUINOLONE Burkholderia_cepacia
        gyrA_D87Y        QUINOLONE Burkholderia_pseudomallei
        gyrA_D95N        QUINOLONE Neisseria
        gyrA_G81C        QUINOLONE Burkholderia_pseudomallei
        gyrA_G81D        QUINOLONE Burkholderia_cepacia
        gyrA_T173A       QUINOLONE Neisseria
        gyrA_T83I        QUINOLONE Burkholderia_pseudomallei
        gyrA_T83I        QUINOLONE Burkholderia_cepacia
        gyrA_T91I        QUINOLONE Neisseria
        gyrA_Y77S        QUINOLONE Burkholderia_pseudomallei
        ompK36_D135DD    CARBAPENEM Klebsiella
        ompR_G63S        BETA-LACTAM Escherichia
        ompR_G63V        BETA-LACTAM Escherichia
        rpoB_D543V       RIFAMPIN Neisseria
        rpoB_H553N       RIFAMPIN Neisseria
        rpoB_H553R       RIFAMPIN Neisseria
        rpoB_H553Y       RIFAMPIN Neisseria
        rpoB_S549F       RIFAMPIN Neisseria
        rpoB_S558F       RIFAMPIN Neisseria
        yciV_DALAALG107del TRIMETHOPRIM-SULFAMETHOXAZOLE Burkholderia_pseudomallei
Changed reference gene catalog records
    armA WP_000359986.1
        product_name:    ArmA family 16S rRNA (guanine(1405)-N(7))-methyltransferase -> 16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA
    blaKPC-41 WP_148044419.1
        product_name:    inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-41 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-41
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-50 WP_171476788.1
        product_name:    inhibitor-resistant class A beta-lactamase KPC-50 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-50
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-53 WP_156649232.1
        pubmed_reference: 33106265 -> 33106265,35647648
    gyrA_D95N WP_003688895.1
        pubmed_reference: 7830580 -> 10799008,7830580
    gyrA_P104S WP_002779062.1
        pubmed_reference: <empty> -> 12493783,12121947,15078520,16553723
    gyrA_P104S WP_002857904.1
        pubmed_reference: <empty> -> 12493783,12121947,15078520,16553723
    gyrA_T86I WP_002779062.1
        pubmed_reference: <empty> -> 12493783,12121947,15078520,16553723
    gyrA_T86I WP_002857904.1
        pubmed_reference: <empty> -> 12493783,12121947,15078520,16553723
    ompF_G141D WP_000977920.1
        class:           FOSFOMYCIN -> BETA-LACTAM
        pubmed_reference: <empty> -> 28072422,10639355
        subclass:        FOSFOMYCIN -> CEPHALOSPORIN
    ompF_G141E WP_000977920.1
        class:           FOSFOMYCIN -> BETA-LACTAM
        pubmed_reference: <empty> -> 10639355
        subclass:        FOSFOMYCIN -> CEPHALOSPORIN
    ompK36_T136TDT WP_002913005.1
        pubmed_reference: 30875398,31477712 -> 30875398,31477712,35816554
    parE_D432H WP_001837315.1
        class:           AMINOCOUMARIN -> QUINOLONE
        pubmed_reference: <empty> -> 21996946
        subclass:        AMINOCOUMARIN -> QUINOLONE
    parE_D432N WP_001837315.1
        class:           AMINOCOUMARIN -> QUINOLONE
        pubmed_reference: <empty> -> 21996946
        subclass:        AMINOCOUMARIN -> QUINOLONE
    parE_G78S WP_001837315.1
        class:           QUINOLONE -> AMINOCOUMARIN
        subclass:        QUINOLONE -> AMINOCOUMARIN
    parE_N470S WP_001837315.1
        class:           AMINOCOUMARIN -> QUINOLONE
        subclass:        AMINOCOUMARIN -> QUINOLONE
    parE_P585S WP_001837315.1
        class:           AMINOCOUMARIN -> QUINOLONE
        pubmed_reference: <empty> -> 21996946
        subclass:        AMINOCOUMARIN -> QUINOLONE
    parE_R136G WP_001837315.1
        class:           QUINOLONE -> AMINOCOUMARIN
        subclass:        QUINOLONE -> AMINOCOUMARIN

Hierarchy nodes added
    core AMR AMR
        blaNWM           blaNWM                         NWM family subclass B3 metallo-beta-lactamase
        blaOXY-11        blaOXY                         OXY-11 family extended-spectrum class A beta-lactamase
        blaOXY-12        blaOXY                         OXY-12 family extended-spectrum class A beta-lactamase
        blaOXY-7         blaOXY                         OXY-7 family extended-spectrum class A beta-lactamase
        blaOXY-8         blaOXY                         OXY-8 family extended-spectrum class A beta-lactamase
        blaOXY-9         blaOXY                         OXY-9 family extended-spectrum class A beta-lactamase
        blaSIE           blaSIE                         SIE family subclass B3 metallo-beta-lactamase
        erm(53)          erm(53)                        23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(53)
        erm(54)          erm(54)                        23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(54)
        lnu(H)           lnu(H) NF040958.1              lincosamide nucleotidyltransferase Lnu(H)
        mef(H)           mef(H)                         macrolide efflux MFS transporter Mef(H)
        mef(J)           mef(J)                         macrolide efflux MFS transporter Mef(J)
        poxtA-Ef         poxtA-Ef                       ABC-F type ribosomal protection protein PoxtA-Ef
Hierarchy nodes removed
Changed Hierarchy Nodes
    armA             16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA
        name:            ArmA family 16S rRNA (guanine(1405)-N(7))-methyltransferase -> 16S rRNA (guanine(1405)-N(7))-methyltransferase ArmA
    blaHBL           HBL family class A beta-lactamase
        hmm_acc:         <empty> -> NF040780.1
    blaHER           HER family class A beta-lactamase
        hmm_acc:         <empty> -> NF040940.1
    blaRAHN          RAHN family extended-spectrum class A beta-lactamase
        hmm_acc:         <empty> -> NF040934.1
        name:            RAHN family class A beta-lactamase -> RAHN family extended-spectrum class A beta-lactamase
    blaWUS           WUS family subclass B1 metallo-beta-lactamase
        hmm_acc:         <empty> -> NF040860.1


----------------------------------------------------------------------
Changes included in 2022-05-26.1
----------------------------------------------------------------------

Overview:

- NCBI has changed two allele numbers for two rare alleles in the blaROB
  family, in order to make database numbering match the tentative usage in
  Kadlec, et al. (2019) (PMID:30561662). The protein AGH37381.1, previously
  called blaROB-2, has a new designation, blaROB-13. AWU47610.1, which had been
  blaROB-9, is now blaROB-2, which is interesting because so far it is the only
  extended-spectrum in the family. The designation blaROB-9 will not be used
  anymore.
- Adjective placement in English is hard. In order to make the the adjective
  placement and order in beta-lactamase product names uniform and consistent a
  bulk change was made to move substrate-specificity-describing-adjectives in
  front of the class description. For example to change "class C
  extended-spectrum beta-lactamase PDC-4" to "extended-spectrum class C
  beta-lactamase PDC-4". The descriptors that may have moved include
  carbapenem-hydrolyzing, cefepime-hydrolyzing, oxicillin-hydrolying,
  extended-spectrum, and broad-spectrum. This was not a change to the
  descriptions or specificity, but just the order of the words in the names so
  that they will all be uniform and consistent.
- The previous class and subclass of poxtA were incorrect and were changed to
  reflect their correct resistance phenotypes.
- Recently added Reference Gene Catalog point mutation fields for refseq_start,
  refseq_stop, refseq_strand, and curated_refseq_start were previously filled
  in for all point mutations, including those with no RefSeq nucleotide (the
  numbers were copied from GenBank coordinates). The fields have been emptied
  where there is no RefSeq accession.
- Continued review of blaOXA alleles led to improved specificity of subclasses
  for many blaOXA alleles and some families see the Reference Gene Hierarchy
  for specifics on family structure:
  https://www.ncbi.nlm.nih.gov/pathogens/genehierarchy
- Many pubmed references added to alleles and families to point to papers with
  more specific characterization
- Review of literature and increased specificity for subclasses of many blaSHV,
  blaKPC, blaGES alleles
- Moved a few blaEC alleles from 'core' to 'plus' on the basis of published
  characterization (pmid: 16801449)
- Proteins names have been revised for blaADC beta-lactamases. As these enzymes
  readily hydrolyze at least one 3rd generation cephalosporin, any allele '#'
  is now named "extended-spectrum class C beta-lactamase ADC-#" except in two
  cases. If the enzyme cleaves cefepime, a fourth-generation cephalosporin, it
  is named "cefepime-hydrolyzing class C beta-lactamase ADC-#". If it cleaves
  any carbapenem, it is named "carbapenem-hydrolyzing class C beta-lactamase
  ADC-#".

Summary:
   Total proteins: 7259
        Core proteins: 6171
        Plus proteins: 1087
   AMR proteins: 6218
   STRESS proteins: 235
   VIRULENCE proteins: 806
   PubMed references: 2508
   Point mutations: 942
   Point mutation reference sequences: 161
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Clostridioides_difficile,
       Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella,
       Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus,
       Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae,
       Streptococcus_pyogenes
   HMMs: 669

Updates since release 2022-04-04.1:
   Proteins added: 33
       Core proteins added: 29
       Plus proteins added: 4
   AMR proteins added: 31
   STRESS proteins added: 1
   VIRULENCE proteins added: 1
   Alleles added: 26
   PubMed references added: 146
   PubMed references removed: 1
   Point mutations added: 3
   Proteins removed: 3
       Core proteins removed: 2
       Plus proteins removed: 1
   Reference Gene Catalog entries changed: 1172
   Hierarchy nodes added: 7
   Hierarchy nodes changed: 41

Added proteins
    core AMR AMR
        fexB             NG_080766.1 WP_002415211.1     chloramphenicol/florfenicol efflux MFS transporter FexB
        erm(52)          NG_080765.1 WP_002571018.1     23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(52)
        erm(51)          NG_080764.1 WP_131386768.1     23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(51)
        erm(50)          NG_080763.1 WP_176453837.1     23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50)
        mef(F)           NG_080767.1 WP_188020219.1     macrolide efflux MFS transporter Mef(F)
        blaACT-108       NG_080768.1 WP_126297136.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-108
        blaACT-GC1       NG_080769.1 WP_249828058.1     extended spectrum class C beta-lactamase ACT-GC1
        blaADC-266       NG_080770.1 WP_249828059.1     extended-spectrum class C beta-lactamase ADC-266
        blaCMY-180       NG_080771.1 WP_060855400.1     class C beta-lactamase CMY-180
        blaGES-52        NG_080772.1 WP_249828060.1     extended-spectrum class A beta-lactamase GES-52
        blaGES-53        NG_080773.1 WP_249828061.1     carbapenem-hydrolyzing class A beta-lactamase GES-53
        blaGMA-1         NG_080774.1 WP_012774820.1     GMA family class A beta-lactamase GMA-1
        blaGMA-2         NG_080775.1 WP_150896653.1     GMA family class A beta-lactamase GMA-2
        blaIMP-96        NG_080776.1 WP_186931965.1     subclass B1 metallo-beta-lactamase IMP-96
        blaKLUG-1        NG_080777.1 WP_249828062.1     CTX-M family extended-spectrum class A beta-lactamase KLUG-1
        blaKPC-125       NG_080778.1 WP_248496376.1     carbapenem-hydrolyzing class A beta-lactamase KPC-125
        blaKPC-126       NG_080779.1 WP_249828063.1     carbapenem-hydrolyzing class A beta-lactamase KPC-126
        blaKPC-93        NG_080780.1 WP_243939160.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-93
        blaNDM-33        NG_080782.1 WP_224452742.1     subclass B1 metallo-beta-lactamase NDM-33
        blaNDM-42        NG_080783.1 WP_249828064.1     subclass B1 metallo-beta-lactamase NDM-42
        blaOXA-1108      NG_080784.1 WP_237920325.1     class D beta-lactamase OXA-1108
        blaOXA-1117      NG_080785.1 WP_249828065.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1117
        blaOXA-1118      NG_080786.1 WP_249828066.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1118
        blaPDC-517       NG_080787.1 WP_249828067.1     class C beta-lactamase PDC-517
        blaPDC-518       NG_080788.1 WP_249828068.1     class C beta-lactamase PDC-518
        blaPJM-1         NG_080789.1 WP_213603971.1     subclass B3 metallo-beta-lactamase PJM-1
        blaSRT-4         NG_080790.1 WP_249828069.1     class C beta-lactamase SRT-4
        blaWUS-1         NG_080791.1 WP_249828070.1     subclass B1 metallo-beta-lactamase WUS-1
        fosA7.9          NG_080792.1 WP_071684814.1     fosfomycin resistance glutathione transferase FosA7.9
    plus AMR AMR
        blaEC-5          AY899338.1 AAW82909.1          cephalosporin-hydrolyzing class C beta-lactamase EC-5
        blaEC-8          DQ092427.1 AAZ85968.1          cephalosporin-hydrolyzing class C beta-lactamase EC-8
    plus STRESS METAL
        arsR             AAXDBA010000092.1 EGO5141043.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR
    plus VIRULENCE VIRULENCE
        tccP              WP_071805594.1                Tir-cytoskeleton coupling protein TccP
Added point mutations
    core AMR POINT
        acrB_R717L       AZITHROMYCIN/CLARITHROMYCIN/ERYTHROMYCIN Escherichia
        acrB_R717Q       AZITHROMYCIN/CLARITHROMYCIN/ERYTHROMYCIN Escherichia
        pmrB_D313N       COLISTIN Klebsiella
Removed proteins
    core AMR AMR
        blaEC-5          NG_049085.1 WP_001443153.1     cephalosporin-hydrolyzing class C beta-lactamase EC-5
        blaEC-8          NG_049086.1 WP_063860454.1     cephalosporin-hydrolyzing class C beta-lactamase EC-8
    plus STRESS METAL
        arsR             CM001159.1 EGJ25781.1          As(III)-sensing metalloregulatory transcriptional repressor ArsR
Changed reference gene catalog records
    pbp2x WP_000872264.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X59
    pbp2x WP_000872267.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X2
    pbp2x WP_000872270.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X4
    pbp2x WP_000872271.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X0
    pbp2x WP_000872273.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X10
    pbp2x WP_000872275.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X3
    pbp2x WP_000872277.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X6
    pbp2x WP_000872282.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X5
    pbp1a WP_001039998.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A1
    pbp1a WP_001040004.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A3
    pbp1a WP_001040010.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A2
    pbp1a WP_001040013.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A0
    pbp2b WP_001224867.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B0
    pbp2b WP_001224871.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B3
    pbp2b WP_001224884.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B2
    pbp2b WP_001224885.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B6
    pbp2b WP_001224886.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B4
    poxtA WP_002415638.1
        class:           MACROLIDE -> PHENICOL/OXAZOLIDINONE
        subclass:        MACROLIDE -> CHLORAMPHENICOL/FLORFENICOL/LINEZOLID
    cfxA WP_004339683.1
        product_name:    CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase
    cfxA3 WP_004348227.1
        product_name:    class A extended-spectrum beta-lactamase CfxA3 -> extended-spectrum class A beta-lactamase CfxA3
    cepA WP_005795628.1
        product_name:    CepA family class A extended-spectrum beta-lactamase -> CepA family extended-spectrum class A beta-lactamase
    cepA WP_005816369.1
        product_name:    CepA family class A extended-spectrum beta-lactamase -> CepA family extended-spectrum class A beta-lactamase
    penI WP_006027381.1
        product_name:    PenI family class A extended-spectrum beta-lactamase -> PenI family extended-spectrum class A beta-lactamase
    penI WP_010108817.1
        product_name:    PenI family class A extended-spectrum beta-lactamase -> PenI family extended-spectrum class A beta-lactamase
    cepA WP_010992371.1
        product_name:    CepA family class A extended-spectrum beta-lactamase -> CepA family extended-spectrum class A beta-lactamase
    penI WP_025370306.1
        product_name:    PenI family class A extended-spectrum beta-lactamase -> PenI family extended-spectrum class A beta-lactamase
    cfxA5 WP_032946415.1
        product_name:    class A broad-spectrum beta-lactamase CfxA5 -> broad-spectrum class A beta-lactamase CfxA5
    pbp2x WP_033707918.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X23
    pbp1a WP_050078510.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A11
    pbp1a WP_050208712.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A12
    pbp2x WP_050293540.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X27
    pbp2x WP_054364452.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X12
    pbp1a WP_054370471.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP1A -> Streptococcus pneumoniae penicillin-binding protein PBP1A9
    cfxA4 WP_057280848.1
        product_name:    class A extended-spectrum beta-lactamase CfxA4 -> extended-spectrum class A beta-lactamase CfxA4
    pbp2b WP_061634854.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2B -> Streptococcus pneumoniae penicillin-binding protein PBP2B5
    pbp2x WP_061745305.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant PBP2X -> Streptococcus pneumoniae penicillin-binding protein PBP2X17
    blaOCH WP_063842730.1
        product_name:    OCH family class C extended-spectrum beta-lactamase -> OCH family extended-spectrum class C beta-lactamase
    blaOKP-B WP_063842745.1
        product_name:    OKP-B family class A broad-spectrum beta-lactamase -> OKP-B family broad-spectrum class A beta-lactamase
    cfxA WP_063843237.1
        product_name:    class A broad-spectrum beta-lactamase CfxA -> broad-spectrum class A beta-lactamase CfxA
    cfxA WP_063843238.1
        product_name:    CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase
    cfxA WP_063843239.1
        product_name:    CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase
    cfxA WP_063843240.1
        product_name:    CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase
    cfxA WP_063843241.1
        product_name:    CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase
    cfxA2 WP_063843242.1
        product_name:    class A extended-spectrum beta-lactamase CfxA2 -> extended-spectrum class A beta-lactamase CfxA2
    cfxA2 WP_063843243.1
        product_name:    class A extended-spectrum beta-lactamase CfxA2 -> extended-spectrum class A beta-lactamase CfxA2
    penI WP_063854501.1
        product_name:    PenI family class A extended-spectrum beta-lactamase -> PenI family extended-spectrum class A beta-lactamase
    cfxA6 WP_117664257.1
        product_name:    class A broad-spectrum beta-lactamase CfxA6 -> broad-spectrum class A beta-lactamase CfxA6
    blaACI-1 WP_006555379.1
        product_name:    class A extended-spectrum beta-lactamase ACI-1 -> extended-spectrum class A beta-lactamase ACI-1
    blaADC-1 WP_004714775.1
        product_name:    class C extended-spectrum beta-lactamase ADC-1 -> extended-spectrum class C beta-lactamase ADC-1
    blaADC-10 WP_063857786.1
        product_name:    class C extended-spectrum beta-lactamase ADC-10 -> extended-spectrum class C beta-lactamase ADC-10
    blaADC-100 WP_068981607.1
        product_name:    class C beta-lactamase ADC-100 -> extended-spectrum class C beta-lactamase ADC-100
    blaADC-101 WP_068981608.1
        product_name:    class C beta-lactamase ADC-101 -> extended-spectrum class C beta-lactamase ADC-101
    blaADC-102 WP_068981609.1
        product_name:    class C beta-lactamase ADC-102 -> extended-spectrum class C beta-lactamase ADC-102
    blaADC-103 WP_068981610.1
        product_name:    class C beta-lactamase ADC-103 -> extended-spectrum class C beta-lactamase ADC-103
    blaADC-104 WP_068981611.1
        product_name:    class C beta-lactamase ADC-104 -> extended-spectrum class C beta-lactamase ADC-104
    blaADC-105 WP_068981612.1
        product_name:    class C beta-lactamase ADC-105 -> extended-spectrum class C beta-lactamase ADC-105
    blaADC-106 WP_068981613.1
        product_name:    class C beta-lactamase ADC-106 -> extended-spectrum class C beta-lactamase ADC-106
    blaADC-107 WP_068981614.1
        product_name:    class C beta-lactamase ADC-107 -> extended-spectrum class C beta-lactamase ADC-107
    blaADC-109 WP_136512052.1
        product_name:    class C beta-lactamase ADC-109 -> extended-spectrum class C beta-lactamase ADC-109
    blaADC-11 WP_001211205.1
        product_name:    class C extended-spectrum beta-lactamase ADC-11 -> extended-spectrum class C beta-lactamase ADC-11
    blaADC-110 WP_136512053.1
        product_name:    class C beta-lactamase ADC-110 -> extended-spectrum class C beta-lactamase ADC-110
    blaADC-112 WP_136512054.1
        product_name:    class C beta-lactamase ADC-112 -> extended-spectrum class C beta-lactamase ADC-112
    blaADC-113 WP_136512055.1
        product_name:    class C beta-lactamase ADC-113 -> extended-spectrum class C beta-lactamase ADC-113
    blaADC-114 WP_125052776.1
        product_name:    class C beta-lactamase ADC-114 -> extended-spectrum class C beta-lactamase ADC-114
    blaADC-115 WP_001211215.1
        product_name:    class C beta-lactamase ADC-115 -> extended-spectrum class C beta-lactamase ADC-115
    blaADC-116 WP_017816757.1
        product_name:    class C beta-lactamase ADC-116 -> extended-spectrum class C beta-lactamase ADC-116
    blaADC-117 WP_002157727.1
        product_name:    class C beta-lactamase ADC-117 -> extended-spectrum class C beta-lactamase ADC-117
    blaADC-119 WP_004712857.1
        product_name:    class C beta-lactamase ADC-119 -> extended-spectrum class C beta-lactamase ADC-119
    blaADC-12 WP_063857787.1
        product_name:    class C extended-spectrum beta-lactamase ADC-12 -> extended-spectrum class C beta-lactamase ADC-12
    blaADC-120 WP_002126587.1
        product_name:    class C beta-lactamase ADC-120 -> extended-spectrum class C beta-lactamase ADC-120
    blaADC-121 WP_005109685.1
        product_name:    class C beta-lactamase ADC-121 -> extended-spectrum class C beta-lactamase ADC-121
    blaADC-122 WP_005123276.1
        product_name:    class C beta-lactamase ADC-122 -> extended-spectrum class C beta-lactamase ADC-122
    blaADC-123 WP_004840559.1
        product_name:    class C beta-lactamase ADC-123 -> extended-spectrum class C beta-lactamase ADC-123
    blaADC-125 WP_005131186.1
        product_name:    class C beta-lactamase ADC-125 -> extended-spectrum class C beta-lactamase ADC-125
    blaADC-127 WP_005046018.1
        product_name:    class C beta-lactamase ADC-127 -> extended-spectrum class C beta-lactamase ADC-127
    blaADC-128 WP_004643536.1
        product_name:    class C beta-lactamase ADC-128 -> extended-spectrum class C beta-lactamase ADC-128
    blaADC-129 WP_005039111.1
        product_name:    class C beta-lactamase ADC-129 -> extended-spectrum class C beta-lactamase ADC-129
    blaADC-13 WP_063857788.1
        product_name:    class C extended-spectrum beta-lactamase ADC-13 -> extended-spectrum class C beta-lactamase ADC-13
    blaADC-130 WP_004886093.1
        product_name:    class C beta-lactamase ADC-130 -> extended-spectrum class C beta-lactamase ADC-130
    blaADC-131 WP_004707701.1
        product_name:    class C beta-lactamase ADC-131 -> extended-spectrum class C beta-lactamase ADC-131
    blaADC-132 WP_005068074.1
        product_name:    class C beta-lactamase ADC-132 -> extended-spectrum class C beta-lactamase ADC-132
    blaADC-133 WP_004700205.1
        product_name:    class C beta-lactamase ADC-133 -> extended-spectrum class C beta-lactamase ADC-133
    blaADC-134 WP_005307218.1
        product_name:    class C beta-lactamase ADC-134 -> extended-spectrum class C beta-lactamase ADC-134
    blaADC-135 WP_004790939.1
        product_name:    class C beta-lactamase ADC-135 -> extended-spectrum class C beta-lactamase ADC-135
    blaADC-136 WP_016137488.1
        product_name:    class C beta-lactamase ADC-136 -> extended-spectrum class C beta-lactamase ADC-136
    blaADC-137 WP_016140427.1
        product_name:    class C beta-lactamase ADC-137 -> extended-spectrum class C beta-lactamase ADC-137
    blaADC-138 WP_016146025.1
        product_name:    class C beta-lactamase ADC-138 -> extended-spectrum class C beta-lactamase ADC-138
    blaADC-139 WP_032039838.1
        product_name:    class C beta-lactamase ADC-139 -> extended-spectrum class C beta-lactamase ADC-139
    blaADC-14 WP_063857789.1
        product_name:    class C extended-spectrum beta-lactamase ADC-14 -> extended-spectrum class C beta-lactamase ADC-14
    blaADC-140 WP_001211209.1
        product_name:    class C beta-lactamase ADC-140 -> extended-spectrum class C beta-lactamase ADC-140
    blaADC-141 WP_032062810.1
        product_name:    class C beta-lactamase ADC-141 -> extended-spectrum class C beta-lactamase ADC-141
    blaADC-143 WP_033502167.1
        product_name:    class C beta-lactamase ADC-143 -> extended-spectrum class C beta-lactamase ADC-143
    blaADC-144 WP_001211214.1
        product_name:    class C beta-lactamase ADC-144 -> cefepime-hydrolyzing class C beta-lactamase ADC-144
        pubmed_reference: <empty> -> 21788456
    blaADC-145 WP_039270258.1
        product_name:    class C beta-lactamase ADC-145 -> extended-spectrum class C beta-lactamase ADC-145
    blaADC-146 WP_039258389.1
        product_name:    class C beta-lactamase ADC-146 -> extended-spectrum class C beta-lactamase ADC-146
    blaADC-147 WP_044718369.1
        product_name:    class C beta-lactamase ADC-147 -> extended-spectrum class C beta-lactamase ADC-147
    blaADC-148 WP_039246976.1
        product_name:    class C beta-lactamase ADC-148 -> extended-spectrum class C beta-lactamase ADC-148
    blaADC-149 WP_014207272.1
        product_name:    class C beta-lactamase ADC-149 -> extended-spectrum class C beta-lactamase ADC-149
    blaADC-15 WP_063857790.1
        product_name:    class C extended-spectrum beta-lactamase ADC-15 -> extended-spectrum class C beta-lactamase ADC-15
    blaADC-150 WP_017386568.1
        product_name:    class C beta-lactamase ADC-150 -> extended-spectrum class C beta-lactamase ADC-150
    blaADC-151 WP_063099318.1
        product_name:    class C beta-lactamase ADC-151 -> extended-spectrum class C beta-lactamase ADC-151
    blaADC-152 WP_001211233.1
        product_name:    class C beta-lactamase ADC-152 -> extended-spectrum class C beta-lactamase ADC-152
    blaADC-153 WP_099156045.1
        product_name:    class C beta-lactamase ADC-153 -> extended-spectrum class C beta-lactamase ADC-153
    blaADC-154 WP_005138362.1
        product_name:    class C beta-lactamase ADC-154 -> extended-spectrum class C beta-lactamase ADC-154
    blaADC-155 WP_005128228.1
        product_name:    class C beta-lactamase ADC-155 -> extended-spectrum class C beta-lactamase ADC-155
    blaADC-156 WP_024436624.1
        product_name:    class C beta-lactamase ADC-156 -> extended-spectrum class C beta-lactamase ADC-156
    blaADC-157 WP_088245227.1
        product_name:    class C beta-lactamase ADC-157 -> extended-spectrum class C beta-lactamase ADC-157
    blaADC-158 WP_001211227.1
        product_name:    class C beta-lactamase ADC-158 -> extended-spectrum class C beta-lactamase ADC-158
    blaADC-159 WP_033851992.1
        product_name:    class C beta-lactamase ADC-159 -> extended-spectrum class C beta-lactamase ADC-159
    blaADC-16 WP_063857791.1
        product_name:    class C extended-spectrum beta-lactamase ADC-16 -> extended-spectrum class C beta-lactamase ADC-16
    blaADC-160 WP_032037870.1
        product_name:    class C beta-lactamase ADC-160 -> extended-spectrum class C beta-lactamase ADC-160
    blaADC-162 WP_031980335.1
        product_name:    class C beta-lactamase ADC-162 -> extended-spectrum class C beta-lactamase ADC-162
    blaADC-163 WP_057093064.1
        product_name:    class C beta-lactamase ADC-163 -> extended-spectrum class C beta-lactamase ADC-163
    blaADC-164 WP_032068214.1
        product_name:    class C beta-lactamase ADC-164 -> extended-spectrum class C beta-lactamase ADC-164
    blaADC-165 WP_001211239.1
        product_name:    class C beta-lactamase ADC-165 -> extended-spectrum class C beta-lactamase ADC-165
    blaADC-166 WP_101244937.1
        product_name:    class C beta-lactamase ADC-166 -> extended-spectrum class C beta-lactamase ADC-166
    blaADC-167 WP_002046804.1
        product_name:    class C beta-lactamase ADC-167 -> extended-spectrum class C beta-lactamase ADC-167
    blaADC-168 WP_101244938.1
        product_name:    class C beta-lactamase ADC-168 -> extended-spectrum class C beta-lactamase ADC-168
    blaADC-169 WP_001211212.1
        product_name:    class C beta-lactamase ADC-169 -> extended-spectrum class C beta-lactamase ADC-169
    blaADC-17 WP_063857792.1
        product_name:    class C extended-spectrum beta-lactamase ADC-17 -> extended-spectrum class C beta-lactamase ADC-17
    blaADC-170 WP_102607458.1
        product_name:    class C beta-lactamase ADC-170 -> extended-spectrum class C beta-lactamase ADC-170
    blaADC-171 WP_031961878.1
        product_name:    class C beta-lactamase ADC-171 -> cefepime-hydrolyzing class C beta-lactamase ADC-171
    blaADC-172 WP_032027415.1
        product_name:    class C beta-lactamase ADC-172 -> cefepime-hydrolyzing class C beta-lactamase ADC-172
    blaADC-173 WP_032071188.1
        product_name:    class C beta-lactamase ADC-173 -> cefepime-hydrolyzing class C beta-lactamase ADC-173
    blaADC-174 WP_114699268.1
        product_name:    class C beta-lactamase ADC-174 -> extended-spectrum class C beta-lactamase ADC-174
    blaADC-175 WP_001211208.1
        product_name:    class C beta-lactamase ADC-175 -> extended-spectrum class C beta-lactamase ADC-175
    blaADC-176 WP_001159761.1
        product_name:    class C beta-lactamase ADC-176 -> extended-spectrum class C beta-lactamase ADC-176
    blaADC-177 WP_114699269.1
        product_name:    class C beta-lactamase ADC-177 -> cefepime-hydrolyzing class C beta-lactamase ADC-177
        pubmed_reference: <empty> -> 21788456
    blaADC-178 WP_114699270.1
        product_name:    class C beta-lactamase ADC-178 -> extended-spectrum class C beta-lactamase ADC-178
    blaADC-179 WP_114699271.1
        product_name:    class C beta-lactamase ADC-179 -> extended-spectrum class C beta-lactamase ADC-179
    blaADC-18 WP_002118772.1
        product_name:    class C extended-spectrum beta-lactamase ADC-18 -> extended-spectrum class C beta-lactamase ADC-18
    blaADC-180 WP_114699272.1
        product_name:    class C beta-lactamase ADC-180 -> extended-spectrum class C beta-lactamase ADC-180
    blaADC-181 WP_046693238.1
        product_name:    class C beta-lactamase ADC-181 -> extended-spectrum class C beta-lactamase ADC-181
    blaADC-182 WP_057691114.1
        product_name:    class C beta-lactamase ADC-182 -> extended-spectrum class C beta-lactamase ADC-182
    blaADC-183 WP_128268232.1
        product_name:    class C beta-lactamase ADC-183 -> extended-spectrum class C beta-lactamase ADC-183
    blaADC-184 WP_059247009.1
        product_name:    class C beta-lactamase ADC-184 -> extended-spectrum class C beta-lactamase ADC-184
    blaADC-185 WP_001211210.1
        product_name:    class C beta-lactamase ADC-185 -> extended-spectrum class C beta-lactamase ADC-185
    blaADC-186 WP_072292271.1
        product_name:    class C beta-lactamase ADC-186 -> extended-spectrum class C beta-lactamase ADC-186
    blaADC-187 WP_136512056.1
        product_name:    class C beta-lactamase ADC-187 -> extended-spectrum class C beta-lactamase ADC-187
    blaADC-188 WP_136512057.1
        product_name:    class C beta-lactamase ADC-188 -> extended-spectrum class C beta-lactamase ADC-188
    blaADC-189 WP_136512058.1
        product_name:    class C beta-lactamase ADC-189 -> extended-spectrum class C beta-lactamase ADC-189
    blaADC-19 WP_063857793.1
        product_name:    class C extended-spectrum beta-lactamase ADC-19 -> extended-spectrum class C beta-lactamase ADC-19
    blaADC-190 WP_136512059.1
        product_name:    class C beta-lactamase ADC-190 -> extended-spectrum class C beta-lactamase ADC-190
    blaADC-191 WP_003112187.1
        product_name:    class C beta-lactamase ADC-191 -> extended-spectrum class C beta-lactamase ADC-191
    blaADC-192 WP_136512060.1
        product_name:    class C beta-lactamase ADC-192 -> extended-spectrum class C beta-lactamase ADC-192
    blaADC-193 WP_013197184.1
        product_name:    class C beta-lactamase ADC-193 -> extended-spectrum class C beta-lactamase ADC-193
    blaADC-194 WP_133972424.1
        product_name:    class C beta-lactamase ADC-194 -> extended-spectrum class C beta-lactamase ADC-194
    blaADC-195 WP_140423305.1
        product_name:    class C beta-lactamase ADC-195 -> extended-spectrum class C beta-lactamase ADC-195
    blaADC-196 WP_145850033.1
        product_name:    class C beta-lactamase ADC-196 -> extended-spectrum class C beta-lactamase ADC-196
    blaADC-197 WP_150823452.1
        product_name:    class C beta-lactamase ADC-197 -> extended-spectrum class C beta-lactamase ADC-197
    blaADC-198 WP_150823453.1
        product_name:    class C beta-lactamase ADC-198 -> extended-spectrum class C beta-lactamase ADC-198
    blaADC-199 WP_114166683.1
        product_name:    class C beta-lactamase ADC-199 -> extended-spectrum class C beta-lactamase ADC-199
    blaADC-2 WP_004746565.1
        product_name:    class C beta-lactamase ADC-2 -> extended-spectrum class C beta-lactamase ADC-2
    blaADC-20 WP_063857794.1
        product_name:    class C extended-spectrum beta-lactamase ADC-20 -> extended-spectrum class C beta-lactamase ADC-20
    blaADC-200 WP_150823454.1
        product_name:    class C beta-lactamase ADC-200 -> extended-spectrum class C beta-lactamase ADC-200
    blaADC-201 WP_150823455.1
        product_name:    class C beta-lactamase ADC-201 -> extended-spectrum class C beta-lactamase ADC-201
    blaADC-202 WP_150823456.1
        product_name:    class C beta-lactamase ADC-202 -> extended-spectrum class C beta-lactamase ADC-202
    blaADC-203 WP_032000414.1
        product_name:    class C beta-lactamase ADC-203 -> extended-spectrum class C beta-lactamase ADC-203
    blaADC-204 WP_150823457.1
        product_name:    class C beta-lactamase ADC-204 -> extended-spectrum class C beta-lactamase ADC-204
    blaADC-205 WP_150823458.1
        product_name:    class C beta-lactamase ADC-205 -> extended-spectrum class C beta-lactamase ADC-205
    blaADC-206 WP_150823459.1
        product_name:    class C beta-lactamase ADC-206 -> extended-spectrum class C beta-lactamase ADC-206
    blaADC-207 WP_130173437.1
        product_name:    class C beta-lactamase ADC-207 -> extended-spectrum class C beta-lactamase ADC-207
    blaADC-208 WP_150823460.1
        product_name:    class C beta-lactamase ADC-208 -> extended-spectrum class C beta-lactamase ADC-208
    blaADC-209 WP_150823461.1
        product_name:    class C beta-lactamase ADC-209 -> extended-spectrum class C beta-lactamase ADC-209
    blaADC-21 WP_063857795.1
        product_name:    class C extended-spectrum beta-lactamase ADC-21 -> extended-spectrum class C beta-lactamase ADC-21
    blaADC-210 WP_150823462.1
        product_name:    class C beta-lactamase ADC-210 -> extended-spectrum class C beta-lactamase ADC-210
    blaADC-211 WP_150823463.1
        product_name:    class C beta-lactamase ADC-211 -> extended-spectrum class C beta-lactamase ADC-211
    blaADC-212 WP_031975357.1
        product_name:    class C beta-lactamase ADC-212 -> extended-spectrum class C beta-lactamase ADC-212
    blaADC-213 WP_078230092.1
        product_name:    class C beta-lactamase ADC-213 -> extended-spectrum class C beta-lactamase ADC-213
    blaADC-214 WP_060454527.1
        product_name:    class C beta-lactamase ADC-214 -> extended-spectrum class C beta-lactamase ADC-214
    blaADC-215 WP_039098799.1
        product_name:    class C beta-lactamase ADC-215 -> extended-spectrum class C beta-lactamase ADC-215
    blaADC-216 WP_039211240.1
        product_name:    class C beta-lactamase ADC-216 -> extended-spectrum class C beta-lactamase ADC-216
    blaADC-217 WP_060470109.1
        product_name:    class C beta-lactamase ADC-217 -> extended-spectrum class C beta-lactamase ADC-217
    blaADC-218 WP_078216190.1
        product_name:    class C beta-lactamase ADC-218 -> extended-spectrum class C beta-lactamase ADC-218
    blaADC-219 WP_039213353.1
        product_name:    class C beta-lactamase ADC-219 -> cefepime-hydrolyzing class C beta-lactamase ADC-219
    blaADC-22 WP_063857796.1
        product_name:    class C extended-spectrum beta-lactamase ADC-22 -> extended-spectrum class C beta-lactamase ADC-22
    blaADC-220 WP_087876534.1
        product_name:    class C beta-lactamase ADC-220 -> extended-spectrum class C beta-lactamase ADC-220
    blaADC-221 WP_156404644.1
        product_name:    class C beta-lactamase ADC-221 -> extended-spectrum class C beta-lactamase ADC-221
    blaADC-222 WP_031960999.1
        product_name:    class C beta-lactamase ADC-222 -> extended-spectrum class C beta-lactamase ADC-222
    blaADC-223 WP_064987478.1
        product_name:    class C beta-lactamase ADC-223 -> extended-spectrum class C beta-lactamase ADC-223
    blaADC-224 WP_064907831.1
        product_name:    class C beta-lactamase ADC-224 -> cefepime-hydrolyzing class C beta-lactamase ADC-224
    blaADC-225 WP_160164833.1
        product_name:    class C beta-lactamase ADC-225 -> cefepime-hydrolyzing class C beta-lactamase ADC-225
    blaADC-226 WP_001211224.1
        product_name:    class C beta-lactamase ADC-226 -> extended-spectrum class C beta-lactamase ADC-226
    blaADC-227 WP_160164834.1
        product_name:    class C beta-lactamase ADC-227 -> extended-spectrum class C beta-lactamase ADC-227
    blaADC-228 WP_160164835.1
        product_name:    class C beta-lactamase ADC-228 -> cefepime-hydrolyzing class C beta-lactamase ADC-228
    blaADC-229 WP_160164836.1
        product_name:    class C beta-lactamase ADC-229 -> extended-spectrum class C beta-lactamase ADC-229
    blaADC-23 WP_063857797.1
        product_name:    class C extended-spectrum beta-lactamase ADC-23 -> extended-spectrum class C beta-lactamase ADC-23
    blaADC-230 WP_160164837.1
        product_name:    class C beta-lactamase ADC-230 -> extended-spectrum class C beta-lactamase ADC-230
    blaADC-231 WP_160164838.1
        product_name:    class C beta-lactamase ADC-231 -> extended-spectrum class C beta-lactamase ADC-231
    blaADC-232 WP_064907116.1
        product_name:    class C beta-lactamase ADC-232 -> cefepime-hydrolyzing class C beta-lactamase ADC-232
    blaADC-233 WP_031950434.1
        product_name:    class C beta-lactamase ADC-233 -> cefepime-hydrolyzing class C beta-lactamase ADC-233
    blaADC-234 WP_159162532.1
        product_name:    class C beta-lactamase ADC-234 -> extended-spectrum class C beta-lactamase ADC-234
    blaADC-235 WP_132038428.1
        product_name:    class C beta-lactamase ADC-235 -> extended-spectrum class C beta-lactamase ADC-235
    blaADC-236 WP_176673601.1
        product_name:    class C beta-lactamase ADC-236 -> extended-spectrum class C beta-lactamase ADC-236
    blaADC-237 WP_086262823.1
        product_name:    class C beta-lactamase ADC-237 -> extended-spectrum class C beta-lactamase ADC-237
    blaADC-238 WP_002058891.1
        product_name:    class C beta-lactamase ADC-238 -> extended-spectrum class C beta-lactamase ADC-238
    blaADC-239 WP_031981814.1
        product_name:    class C beta-lactamase ADC-239 -> extended-spectrum class C beta-lactamase ADC-239
    blaADC-24 WP_136512061.1
        product_name:    class C beta-lactamase ADC-24 -> extended-spectrum class C beta-lactamase ADC-24
    blaADC-240 WP_001211207.1
        product_name:    class C beta-lactamase ADC-240 -> extended-spectrum class C beta-lactamase ADC-240
    blaADC-241 WP_001211198.1
        product_name:    class C beta-lactamase ADC-241 -> extended-spectrum class C beta-lactamase ADC-241
    blaADC-242 WP_047481394.1
        product_name:    class C beta-lactamase ADC-242 -> extended-spectrum class C beta-lactamase ADC-242
    blaADC-243 WP_001211199.1
        product_name:    class C beta-lactamase ADC-243 -> extended-spectrum class C beta-lactamase ADC-243
    blaADC-244 WP_032017586.1
        product_name:    class C beta-lactamase ADC-244 -> extended-spectrum class C beta-lactamase ADC-244
    blaADC-245 WP_032005249.1
        product_name:    class C beta-lactamase ADC-245 -> extended-spectrum class C beta-lactamase ADC-245
    blaADC-246 WP_031976577.1
        product_name:    class C beta-lactamase ADC-246 -> extended-spectrum class C beta-lactamase ADC-246
    blaADC-247 WP_032058755.1
        product_name:    class C beta-lactamase ADC-247 -> extended-spectrum class C beta-lactamase ADC-247
    blaADC-248 WP_021511005.1
        product_name:    class C beta-lactamase ADC-248 -> extended-spectrum class C beta-lactamase ADC-248
    blaADC-249 WP_001211200.1
        product_name:    class C beta-lactamase ADC-249 -> extended-spectrum class C beta-lactamase ADC-249
    blaADC-25 WP_001211217.1
        product_name:    class C beta-lactamase ADC-25 -> extended-spectrum class C beta-lactamase ADC-25
    blaADC-250 WP_086329657.1
        product_name:    class C beta-lactamase ADC-250 -> extended-spectrum class C beta-lactamase ADC-250
    blaADC-251 WP_086443396.1
        product_name:    class C beta-lactamase ADC-251 -> extended-spectrum class C beta-lactamase ADC-251
    blaADC-252 WP_086399847.1
        product_name:    class C beta-lactamase ADC-252 -> extended-spectrum class C beta-lactamase ADC-252
    blaADC-253 WP_086394244.1
        product_name:    class C beta-lactamase ADC-253 -> extended-spectrum class C beta-lactamase ADC-253
    blaADC-254 WP_031996777.1
        product_name:    class C beta-lactamase ADC-254 -> extended-spectrum class C beta-lactamase ADC-254
    blaADC-255 WP_022575343.1
        product_name:    class C beta-lactamase ADC-255 -> extended-spectrum class C beta-lactamase ADC-255
    blaADC-256 WP_204376223.1
        product_name:    class C beta-lactamase ADC-256 -> extended-spectrum class C beta-lactamase ADC-256
    blaADC-257 WP_116020564.1
        product_name:    class C beta-lactamase ADC-257 -> extended-spectrum class C beta-lactamase ADC-257
    blaADC-258 WP_114259520.1
        product_name:    class C beta-lactamase ADC-258 -> extended-spectrum class C beta-lactamase ADC-258
    blaADC-259 WP_046882921.1
        product_name:    class C beta-lactamase ADC-259 -> extended-spectrum class C beta-lactamase ADC-259
    blaADC-26 WP_001211238.1
        product_name:    class C extended-spectrum beta-lactamase ADC-26 -> extended-spectrum class C beta-lactamase ADC-26
    blaADC-260 WP_231869648.1
        product_name:    class C beta-lactamase ADC-260 -> extended-spectrum class C beta-lactamase ADC-260
    blaADC-261 WP_240067715.1
        product_name:    class C beta-lactamase ADC-261 -> cefepime-hydrolyzing class C beta-lactamase ADC-261
        pubmed_reference: <empty> -> 21788456
    blaADC-262 WP_213702342.1
        product_name:    class C beta-lactamase ADC-262 -> extended-spectrum class C beta-lactamase ADC-262
    blaADC-263 WP_109433738.1
        product_name:    class C beta-lactamase ADC-263 -> extended-spectrum class C beta-lactamase ADC-263
    blaADC-264 WP_240067716.1
        product_name:    class C beta-lactamase ADC-264 -> extended-spectrum class C beta-lactamase ADC-264
    blaADC-265 WP_086265799.1
        product_name:    class C beta-lactamase ADC-265 -> extended-spectrum class C beta-lactamase ADC-265
    blaADC-29 WP_069174569.1
        product_name:    class C extended-spectrum beta-lactamase ADC-29 -> extended-spectrum class C beta-lactamase ADC-29
    blaADC-3 WP_063857798.1
        product_name:    class C beta-lactamase ADC-3 -> extended-spectrum class C beta-lactamase ADC-3
    blaADC-30 WP_001211218.1
        product_name:    class C extended-spectrum beta-lactamase ADC-30 -> extended-spectrum class C beta-lactamase ADC-30
    blaADC-31 WP_001211223.1
        product_name:    class C extended-spectrum beta-lactamase ADC-31 -> extended-spectrum class C beta-lactamase ADC-31
    blaADC-32 WP_004739487.1
        product_name:    class C extended-spectrum beta-lactamase ADC-32 -> extended-spectrum class C beta-lactamase ADC-32
    blaADC-33 WP_001211220.1
        product_name:    cefepime-hydrolyzing class C extended-spectrum beta-lactamase ADC-33 -> cefepime-hydrolyzing class C beta-lactamase ADC-33
    blaADC-38 WP_063857799.1
        product_name:    class C beta-lactamase ADC-38 -> extended-spectrum class C beta-lactamase ADC-38
    blaADC-39 WP_063857800.1
        product_name:    class C beta-lactamase ADC-39 -> extended-spectrum class C beta-lactamase ADC-39
    blaADC-4 WP_063857801.1
        product_name:    class C beta-lactamase ADC-4 -> extended-spectrum class C beta-lactamase ADC-4
    blaADC-41 WP_063857802.1
        product_name:    class C extended-spectrum beta-lactamase ADC-41 -> extended-spectrum class C beta-lactamase ADC-41
    blaADC-42 WP_063857803.1
        product_name:    class C extended-spectrum beta-lactamase ADC-42 -> extended-spectrum class C beta-lactamase ADC-42
    blaADC-43 WP_032055358.1
        product_name:    class C extended-spectrum beta-lactamase ADC-43 -> extended-spectrum class C beta-lactamase ADC-43
    blaADC-44 WP_063857804.1
        product_name:    class C extended-spectrum beta-lactamase ADC-44 -> extended-spectrum class C beta-lactamase ADC-44
    blaADC-5 WP_038405930.1
        product_name:    class C beta-lactamase ADC-5 -> extended-spectrum class C beta-lactamase ADC-5
    blaADC-50 WP_031965243.1
        product_name:    class C extended-spectrum beta-lactamase ADC-50 -> extended-spectrum class C beta-lactamase ADC-50
    blaADC-51 WP_063857805.1
        product_name:    class C extended-spectrum beta-lactamase ADC-51 -> extended-spectrum class C beta-lactamase ADC-51
    blaADC-52 WP_001211232.1
        product_name:    class C extended-spectrum beta-lactamase ADC-52 -> extended-spectrum class C beta-lactamase ADC-52
    blaADC-53 WP_063857806.1
        product_name:    class C extended-spectrum beta-lactamase ADC-53 -> extended-spectrum class C beta-lactamase ADC-53
    blaADC-54 WP_063857807.1
        product_name:    class C beta-lactamase ADC-54 -> extended-spectrum class C beta-lactamase ADC-54
    blaADC-56 WP_031973850.1
        product_name:    cefepime-hydrolyzing class C extended-spectrum beta-lactamase ADC-56 -> cefepime-hydrolyzing class C beta-lactamase ADC-56
    blaADC-57 WP_001211226.1
        product_name:    class C beta-lactamase ADC-57 -> extended-spectrum class C beta-lactamase ADC-57
    blaADC-58 WP_063857808.1
        product_name:    class C beta-lactamase ADC-58 -> extended-spectrum class C beta-lactamase ADC-58
    blaADC-59 WP_063857809.1
        product_name:    class C beta-lactamase ADC-59 -> extended-spectrum class C beta-lactamase ADC-59
    blaADC-6 WP_017725267.1
        product_name:    class C beta-lactamase ADC-6 -> extended-spectrum class C beta-lactamase ADC-6
    blaADC-60 WP_063857810.1
        product_name:    class C beta-lactamase ADC-60 -> extended-spectrum class C beta-lactamase ADC-60
    blaADC-61 WP_033503051.1
        product_name:    class C beta-lactamase ADC-61 -> extended-spectrum class C beta-lactamase ADC-61
    blaADC-62 WP_063857811.1
        product_name:    class C beta-lactamase ADC-62 -> extended-spectrum class C beta-lactamase ADC-62
    blaADC-63 WP_063857812.1
        product_name:    class C beta-lactamase ADC-63 -> extended-spectrum class C beta-lactamase ADC-63
    blaADC-65 WP_136512062.1
        product_name:    class C beta-lactamase ADC-65 -> extended-spectrum class C beta-lactamase ADC-65
    blaADC-66 WP_136512063.1
        product_name:    class C beta-lactamase ADC-66 -> extended-spectrum class C beta-lactamase ADC-66
    blaADC-67 WP_063857814.1
        product_name:    class C beta-lactamase ADC-67 -> extended-spectrum class C beta-lactamase ADC-67
    blaADC-7 WP_063857816.1
        product_name:    class C beta-lactamase ADC-7 -> extended-spectrum class C beta-lactamase ADC-7
    blaADC-70 WP_017480710.1
        product_name:    class C extended-spectrum beta-lactamase ADC-70 -> extended-spectrum class C beta-lactamase ADC-70
    blaADC-73 WP_001211219.1
        product_name:    class C extended-spectrum beta-lactamase ADC-73 -> extended-spectrum class C beta-lactamase ADC-73
    blaADC-74 WP_001211203.1
        product_name:    class C extended-spectrum beta-lactamase ADC-74 -> extended-spectrum class C beta-lactamase ADC-74
    blaADC-75 WP_063857817.1
        product_name:    class C extended-spectrum beta-lactamase ADC-75 -> extended-spectrum class C beta-lactamase ADC-75
    blaADC-76 WP_001211237.1
        product_name:    class C extended-spectrum beta-lactamase ADC-76 -> extended-spectrum class C beta-lactamase ADC-76
    blaADC-77 WP_063857818.1
        product_name:    class C extended-spectrum beta-lactamase ADC-77 -> extended-spectrum class C beta-lactamase ADC-77
    blaADC-78 WP_057691006.1
        product_name:    class C extended-spectrum beta-lactamase ADC-78 -> extended-spectrum class C beta-lactamase ADC-78
    blaADC-79 WP_001159760.1
        product_name:    class C extended-spectrum beta-lactamase ADC-79 -> extended-spectrum class C beta-lactamase ADC-79
    blaADC-80 WP_029424536.1
        product_name:    class C extended-spectrum beta-lactamase ADC-80 -> extended-spectrum class C beta-lactamase ADC-80
    blaADC-81 WP_059262723.1
        product_name:    class C extended-spectrum beta-lactamase ADC-81 -> extended-spectrum class C beta-lactamase ADC-81
    blaADC-82 WP_001211216.1
        product_name:    class C extended-spectrum beta-lactamase ADC-82 -> extended-spectrum class C beta-lactamase ADC-82
    blaADC-83 WP_068981615.1
        product_name:    class C beta-lactamase ADC-83 -> extended-spectrum class C beta-lactamase ADC-83
    blaADC-84 WP_068981616.1
        product_name:    class C beta-lactamase ADC-84 -> extended-spectrum class C beta-lactamase ADC-84
    blaADC-85 WP_068981617.1
        product_name:    class C beta-lactamase ADC-85 -> extended-spectrum class C beta-lactamase ADC-85
    blaADC-86 WP_068981618.1
        product_name:    class C beta-lactamase ADC-86 -> extended-spectrum class C beta-lactamase ADC-86
    blaADC-87 WP_068981619.1
        product_name:    class C beta-lactamase ADC-87 -> extended-spectrum class C beta-lactamase ADC-87
    blaADC-88 WP_001211221.1
        product_name:    class C beta-lactamase ADC-88 -> extended-spectrum class C beta-lactamase ADC-88
    blaADC-89 WP_068981620.1
        product_name:    class C beta-lactamase ADC-89 -> extended-spectrum class C beta-lactamase ADC-89
    blaADC-90 WP_068981621.1
        product_name:    class C beta-lactamase ADC-90 -> extended-spectrum class C beta-lactamase ADC-90
    blaADC-91 WP_068981622.1
        product_name:    class C beta-lactamase ADC-91 -> extended-spectrum class C beta-lactamase ADC-91
    blaADC-92 WP_068981623.1
        product_name:    class C beta-lactamase ADC-92 -> extended-spectrum class C beta-lactamase ADC-92
    blaADC-93 WP_068981624.1
        product_name:    class C beta-lactamase ADC-93 -> extended-spectrum class C beta-lactamase ADC-93
    blaADC-94 WP_068981625.1
        product_name:    class C beta-lactamase ADC-94 -> extended-spectrum class C beta-lactamase ADC-94
    blaADC-95 WP_068981626.1
        product_name:    class C beta-lactamase ADC-95 -> extended-spectrum class C beta-lactamase ADC-95
    blaADC-96 WP_068981627.1
        product_name:    class C beta-lactamase ADC-96 -> extended-spectrum class C beta-lactamase ADC-96
    blaADC-97 WP_068981628.1
        product_name:    class C beta-lactamase ADC-97 -> extended-spectrum class C beta-lactamase ADC-97
    blaADC-98 WP_068981629.1
        product_name:    class C beta-lactamase ADC-98 -> extended-spectrum class C beta-lactamase ADC-98
    blaADC-99 WP_068981630.1
        product_name:    class C beta-lactamase ADC-99 -> extended-spectrum class C beta-lactamase ADC-99
    blaAST-1 WP_063857821.1
        product_name:    class A broad-spectrum beta-lactamase AST-1 -> broad-spectrum class A beta-lactamase AST-1
    blaBEL-1 WP_063857830.1
        product_name:    class A extended-spectrum beta-lactamase BEL-1 -> extended-spectrum class A beta-lactamase BEL-1
    blaBEL-2 WP_063857831.1
        product_name:    class A extended-spectrum beta-lactamase BEL-2 -> extended-spectrum class A beta-lactamase BEL-2
    blaBEL-3 WP_063857832.1
        product_name:    class A extended-spectrum beta-lactamase BEL-3 -> extended-spectrum class A beta-lactamase BEL-3
    blaBEL-4 WP_065158950.1
        product_name:    class A extended-spectrum beta-lactamase BEL-4 -> extended-spectrum class A beta-lactamase BEL-4
    blaCARB-10 WP_063857836.1
        product_name:    RTG family carbenicillin-hydrolyzing class A extended-spectrum beta-lactamase CARB-10 -> RTG family carbenicillin-hydrolyzing extended-spectrum class A beta-lactamase CARB-10
    blaCGA-1 WP_002977989.1
        product_name:    class A extended-spectrum beta-lactamase CGA-1 -> extended-spectrum class A beta-lactamase CGA-1
    blaCIA-1 WP_034735227.1
        product_name:    class A extended-spectrum beta-lactamase CIA-1 -> extended-spectrum class A beta-lactamase CIA-1
    blaCIA-2 WP_063859465.1
        product_name:    class A extended-spectrum beta-lactamase CIA-2 -> extended-spectrum class A beta-lactamase CIA-2
    blaCIA-3 WP_063859478.1
        product_name:    class A extended-spectrum beta-lactamase CIA-3 -> extended-spectrum class A beta-lactamase CIA-3
    blaCIA-4 WP_027373439.1
        product_name:    class A extended-spectrum beta-lactamase CIA-4 -> extended-spectrum class A beta-lactamase CIA-4
    blaCME-1 WP_059330348.1
        product_name:    class A extended-spectrum beta-lactamase CME-1 -> extended-spectrum class A beta-lactamase CME-1
    blaCME-2 WP_063859570.1
        product_name:    class A extended-spectrum beta-lactamase CME-2 -> extended-spectrum class A beta-lactamase CME-2
    blaCME-3 WP_009085188.1
        product_name:    class A extended-spectrum beta-lactamase CME-3 -> extended-spectrum class A beta-lactamase CME-3
    blaCMY-179 WP_187259226.1
        gene_family:     blaCFE -> blaCMY
    blaCMY-30 WP_000976513.1
        product_name:    class C extended-spectrum beta-lactamase CMY-30 -> extended-spectrum class C beta-lactamase CMY-30
    blaCMY-37 WP_063859838.1
        product_name:    class C extended-spectrum beta-lactamase CMY-37 -> extended-spectrum class C beta-lactamase CMY-37
    blaCMY-42 WP_039023136.1
        product_name:    class C extended-spectrum beta-lactamase CMY-42 -> extended-spectrum class C beta-lactamase CMY-42
    blaCMY-8 WP_012477380.1
        product_name:    CMY-1/MOX family class C extended-spectrum beta-lactamase CMY-8 -> CMY-1/MOX family extended-spectrum class C beta-lactamase CMY-8
    blaCMY-9 WP_032490177.1
        product_name:    CMY-1/MOX family class C extended-spectrum beta-lactamase CMY-9 -> CMY-1/MOX family extended-spectrum class C beta-lactamase CMY-9
    blaCSP-1 WP_063859920.1
        product_name:    class A extended-spectrum beta-lactamase CSP-1 -> extended-spectrum class A beta-lactamase CSP-1
    blaCTX-M-1 WP_013188473.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-1 -> extended-spectrum class A beta-lactamase CTX-M-1
    blaCTX-M-10 WP_032491157.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-10 -> extended-spectrum class A beta-lactamase CTX-M-10
    blaCTX-M-100 WP_032494234.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-100 -> extended-spectrum class A beta-lactamase CTX-M-100
    blaCTX-M-101 WP_063859921.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-101 -> extended-spectrum class A beta-lactamase CTX-M-101
    blaCTX-M-102 WP_063859922.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-102 -> extended-spectrum class A beta-lactamase CTX-M-102
    blaCTX-M-103 WP_063859923.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-103 -> extended-spectrum class A beta-lactamase CTX-M-103
    blaCTX-M-104 WP_042004849.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-104 -> extended-spectrum class A beta-lactamase CTX-M-104
    blaCTX-M-105 WP_015059026.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-105 -> extended-spectrum class A beta-lactamase CTX-M-105
    blaCTX-M-110 WP_063859924.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-110 -> extended-spectrum class A beta-lactamase CTX-M-110
    blaCTX-M-111 WP_063859925.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-111 -> extended-spectrum class A beta-lactamase CTX-M-111
    blaCTX-M-112 WP_063859926.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-112 -> extended-spectrum class A beta-lactamase CTX-M-112
    blaCTX-M-113 WP_063859927.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-113 -> extended-spectrum class A beta-lactamase CTX-M-113
    blaCTX-M-114 WP_063859928.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-114 -> extended-spectrum class A beta-lactamase CTX-M-114
    blaCTX-M-115 WP_035895532.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-115 -> extended-spectrum class A beta-lactamase CTX-M-115
    blaCTX-M-116 WP_032495225.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-116 -> extended-spectrum class A beta-lactamase CTX-M-116
    blaCTX-M-117 WP_032495259.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-117 -> extended-spectrum class A beta-lactamase CTX-M-117
    blaCTX-M-12 WP_032491777.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-12 -> extended-spectrum class A beta-lactamase CTX-M-12
    blaCTX-M-121 WP_032495378.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-121 -> extended-spectrum class A beta-lactamase CTX-M-121
    blaCTX-M-122 WP_063859932.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-122 -> extended-spectrum class A beta-lactamase CTX-M-122
    blaCTX-M-123 WP_031942271.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-123 -> extended-spectrum class A beta-lactamase CTX-M-123
    blaCTX-M-124 WP_063859945.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-124 -> extended-spectrum class A beta-lactamase CTX-M-124
    blaCTX-M-125 WP_063859946.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-125 -> extended-spectrum class A beta-lactamase CTX-M-125
    blaCTX-M-126 WP_063859947.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-126 -> extended-spectrum class A beta-lactamase CTX-M-126
    blaCTX-M-127 WP_088245211.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-127 -> extended-spectrum class A beta-lactamase CTX-M-127
    blaCTX-M-129 WP_063859948.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-129 -> extended-spectrum class A beta-lactamase CTX-M-129
    blaCTX-M-13 WP_032489927.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-13 -> extended-spectrum class A beta-lactamase CTX-M-13
    blaCTX-M-130 WP_063859949.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-130 -> extended-spectrum class A beta-lactamase CTX-M-130
    blaCTX-M-131 WP_063859950.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-131 -> extended-spectrum class A beta-lactamase CTX-M-131
    blaCTX-M-132 WP_063859951.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-132 -> extended-spectrum class A beta-lactamase CTX-M-132
    blaCTX-M-134 WP_063859952.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-134 -> extended-spectrum class A beta-lactamase CTX-M-134
    blaCTX-M-136 WP_063859953.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-136 -> extended-spectrum class A beta-lactamase CTX-M-136
    blaCTX-M-137 WP_063859954.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-137 -> extended-spectrum class A beta-lactamase CTX-M-137
    blaCTX-M-138 WP_070064534.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-138 -> extended-spectrum class A beta-lactamase CTX-M-138
    blaCTX-M-139 WP_063859955.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-139 -> extended-spectrum class A beta-lactamase CTX-M-139
    blaCTX-M-14 WP_001617865.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-14 -> extended-spectrum class A beta-lactamase CTX-M-14
    blaCTX-M-140 WP_063108644.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-140 -> extended-spectrum class A beta-lactamase CTX-M-140
    blaCTX-M-141 WP_063859956.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-141 -> extended-spectrum class A beta-lactamase CTX-M-141
    blaCTX-M-142 WP_063859957.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-142 -> extended-spectrum class A beta-lactamase CTX-M-142
    blaCTX-M-143 WP_156404649.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-143 -> extended-spectrum class A beta-lactamase CTX-M-143
    blaCTX-M-144 WP_032495786.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-144 -> extended-spectrum class A beta-lactamase CTX-M-144
    blaCTX-M-146 WP_102607454.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-146 -> extended-spectrum class A beta-lactamase CTX-M-146
    blaCTX-M-147 WP_063859958.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-147 -> extended-spectrum class A beta-lactamase CTX-M-147
    blaCTX-M-148 WP_032495787.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-148 -> extended-spectrum class A beta-lactamase CTX-M-148
    blaCTX-M-15 WP_000239590.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-15 -> extended-spectrum class A beta-lactamase CTX-M-15
    blaCTX-M-150 WP_063859959.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-150 -> extended-spectrum class A beta-lactamase CTX-M-150
    blaCTX-M-151 WP_063859960.1
        product_name:    CTX-M-like class A extended-spectrum beta-lactamase CTX-M-151 -> CTX-M-like extended-spectrum class A beta-lactamase CTX-M-151
    blaCTX-M-152 WP_063859961.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-152 -> extended-spectrum class A beta-lactamase CTX-M-152
    blaCTX-M-153 WP_168247876.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-153 -> extended-spectrum class A beta-lactamase CTX-M-153
    blaCTX-M-154 WP_110093562.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-154 -> extended-spectrum class A beta-lactamase CTX-M-154
    blaCTX-M-155 WP_063859962.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-155 -> extended-spectrum class A beta-lactamase CTX-M-155
    blaCTX-M-156 WP_063859963.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-156 -> extended-spectrum class A beta-lactamase CTX-M-156
    blaCTX-M-157 WP_063859964.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-157 -> extended-spectrum class A beta-lactamase CTX-M-157
    blaCTX-M-158 WP_063859965.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-158 -> extended-spectrum class A beta-lactamase CTX-M-158
    blaCTX-M-159 WP_063859966.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-159 -> extended-spectrum class A beta-lactamase CTX-M-159
    blaCTX-M-16 WP_063859967.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-16 -> extended-spectrum class A beta-lactamase CTX-M-16
    blaCTX-M-160 WP_063859968.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-160 -> extended-spectrum class A beta-lactamase CTX-M-160
    blaCTX-M-161 WP_063859969.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-161 -> extended-spectrum class A beta-lactamase CTX-M-161
    blaCTX-M-162 WP_063859970.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-162 -> extended-spectrum class A beta-lactamase CTX-M-162
    blaCTX-M-163 WP_063859971.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-163 -> extended-spectrum class A beta-lactamase CTX-M-163
    blaCTX-M-164 WP_063859972.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-164 -> extended-spectrum class A beta-lactamase CTX-M-164
    blaCTX-M-165 WP_053444694.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-165 -> extended-spectrum class A beta-lactamase CTX-M-165
    blaCTX-M-166 WP_063859973.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-166 -> extended-spectrum class A beta-lactamase CTX-M-166
    blaCTX-M-167 WP_063859974.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-167 -> extended-spectrum class A beta-lactamase CTX-M-167
    blaCTX-M-168 WP_063859975.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-168 -> extended-spectrum class A beta-lactamase CTX-M-168
    blaCTX-M-169 WP_063859976.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-169 -> extended-spectrum class A beta-lactamase CTX-M-169
    blaCTX-M-17 WP_011117618.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-17 -> extended-spectrum class A beta-lactamase CTX-M-17
    blaCTX-M-170 WP_063859984.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-170 -> extended-spectrum class A beta-lactamase CTX-M-170
    blaCTX-M-171 WP_065419568.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-171 -> extended-spectrum class A beta-lactamase CTX-M-171
    blaCTX-M-172 WP_063859993.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-172 -> extended-spectrum class A beta-lactamase CTX-M-172
    blaCTX-M-173 WP_063859998.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-173 -> extended-spectrum class A beta-lactamase CTX-M-173
    blaCTX-M-174 WP_063860005.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-174 -> extended-spectrum class A beta-lactamase CTX-M-174
    blaCTX-M-175 WP_063860009.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-175 -> extended-spectrum class A beta-lactamase CTX-M-175
    blaCTX-M-176 WP_063860014.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-176 -> extended-spectrum class A beta-lactamase CTX-M-176
    blaCTX-M-177 WP_063860019.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-177 -> extended-spectrum class A beta-lactamase CTX-M-177
    blaCTX-M-178 WP_104009847.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-178 -> extended-spectrum class A beta-lactamase CTX-M-178
    blaCTX-M-179 WP_063860025.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-179 -> extended-spectrum class A beta-lactamase CTX-M-179
    blaCTX-M-180 WP_063860034.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-180 -> extended-spectrum class A beta-lactamase CTX-M-180
    blaCTX-M-181 WP_063860035.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-181 -> extended-spectrum class A beta-lactamase CTX-M-181
    blaCTX-M-182 WP_063860036.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-182 -> extended-spectrum class A beta-lactamase CTX-M-182
    blaCTX-M-183 WP_064511490.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-183 -> extended-spectrum class A beta-lactamase CTX-M-183
    blaCTX-M-184 WP_064511491.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-184 -> extended-spectrum class A beta-lactamase CTX-M-184
    blaCTX-M-185 WP_065102278.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-185 -> extended-spectrum class A beta-lactamase CTX-M-185
    blaCTX-M-186 WP_065419569.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-186 -> extended-spectrum class A beta-lactamase CTX-M-186
    blaCTX-M-187 WP_104009848.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-187 -> extended-spectrum class A beta-lactamase CTX-M-187
    blaCTX-M-188 WP_068981632.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-188 -> extended-spectrum class A beta-lactamase CTX-M-188
    blaCTX-M-189 WP_068981633.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-189 -> extended-spectrum class A beta-lactamase CTX-M-189
    blaCTX-M-19 WP_063860037.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-19 -> extended-spectrum class A beta-lactamase CTX-M-19
    blaCTX-M-190 WP_069280706.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-190 -> extended-spectrum class A beta-lactamase CTX-M-190
    blaCTX-M-191 WP_102607451.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-191 -> extended-spectrum class A beta-lactamase CTX-M-191
    blaCTX-M-192 WP_102607452.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-192 -> extended-spectrum class A beta-lactamase CTX-M-192
    blaCTX-M-193 WP_077767290.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-193 -> extended-spectrum class A beta-lactamase CTX-M-193
    blaCTX-M-194 WP_077767291.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-194 -> extended-spectrum class A beta-lactamase CTX-M-194
    blaCTX-M-195 WP_077767292.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-195 -> extended-spectrum class A beta-lactamase CTX-M-195
    blaCTX-M-196 WP_077767293.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-196 -> extended-spectrum class A beta-lactamase CTX-M-196
    blaCTX-M-197 WP_085562400.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-197 -> extended-spectrum class A beta-lactamase CTX-M-197
    blaCTX-M-198 WP_085562401.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-198 -> extended-spectrum class A beta-lactamase CTX-M-198
    blaCTX-M-199 WP_087587947.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-199 -> extended-spectrum class A beta-lactamase CTX-M-199
    blaCTX-M-2 WP_025368620.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-2 -> extended-spectrum class A beta-lactamase CTX-M-2
    blaCTX-M-20 WP_063860038.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-20 -> extended-spectrum class A beta-lactamase CTX-M-20
    blaCTX-M-200 WP_094009813.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-200 -> extended-spectrum class A beta-lactamase CTX-M-200
    blaCTX-M-201 WP_094009814.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-201 -> extended-spectrum class A beta-lactamase CTX-M-201
    blaCTX-M-202 WP_088245215.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-202 -> extended-spectrum class A beta-lactamase CTX-M-202
    blaCTX-M-203 WP_088245212.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-203 -> extended-spectrum class A beta-lactamase CTX-M-203
    blaCTX-M-204 WP_088245225.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-204 -> extended-spectrum class A beta-lactamase CTX-M-204
    blaCTX-M-205 WP_099156053.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-205 -> extended-spectrum class A beta-lactamase CTX-M-205
    blaCTX-M-206 WP_102607455.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-206 -> extended-spectrum class A beta-lactamase CTX-M-206
    blaCTX-M-207 WP_102607456.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-207 -> extended-spectrum class A beta-lactamase CTX-M-207
    blaCTX-M-208 WP_109545060.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-208 -> extended-spectrum class A beta-lactamase CTX-M-208
    blaCTX-M-209 WP_109545061.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-209 -> extended-spectrum class A beta-lactamase CTX-M-209
    blaCTX-M-21 WP_063860039.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-21 -> extended-spectrum class A beta-lactamase CTX-M-21
    blaCTX-M-210 WP_109545062.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-210 -> extended-spectrum class A beta-lactamase CTX-M-210
    blaCTX-M-211 WP_109545063.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-211 -> extended-spectrum class A beta-lactamase CTX-M-211
    blaCTX-M-212 WP_109545064.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-212 -> extended-spectrum class A beta-lactamase CTX-M-212
    blaCTX-M-213 WP_106924209.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-213 -> extended-spectrum class A beta-lactamase CTX-M-213
    blaCTX-M-214 WP_109545069.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-214 -> extended-spectrum class A beta-lactamase CTX-M-214
    blaCTX-M-215 WP_128268235.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-215 -> extended-spectrum class A beta-lactamase CTX-M-215
    blaCTX-M-216 WP_109791209.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-216 -> extended-spectrum class A beta-lactamase CTX-M-216
    blaCTX-M-217 WP_109791211.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-217 -> extended-spectrum class A beta-lactamase CTX-M-217
    blaCTX-M-218 WP_109791214.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-218 -> extended-spectrum class A beta-lactamase CTX-M-218
    blaCTX-M-219 WP_110092882.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase CTX-M-219 -> inhibitor-resistant extended-spectrum class A beta-lactamase CTX-M-219
    blaCTX-M-22 WP_032491377.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-22 -> extended-spectrum class A beta-lactamase CTX-M-22
    blaCTX-M-220 WP_111672902.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-220 -> extended-spectrum class A beta-lactamase CTX-M-220
    blaCTX-M-221 WP_114699284.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-221 -> extended-spectrum class A beta-lactamase CTX-M-221
    blaCTX-M-222 WP_116786829.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-222 -> extended-spectrum class A beta-lactamase CTX-M-222
    blaCTX-M-223 WP_122630862.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-223 -> extended-spectrum class A beta-lactamase CTX-M-223
    blaCTX-M-224 WP_094166899.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-224 -> extended-spectrum class A beta-lactamase CTX-M-224
    blaCTX-M-225 WP_136512064.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-225 -> extended-spectrum class A beta-lactamase CTX-M-225
    blaCTX-M-226 WP_136512065.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-226 -> extended-spectrum class A beta-lactamase CTX-M-226
    blaCTX-M-227 WP_148044409.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-227 -> extended-spectrum class A beta-lactamase CTX-M-227
    blaCTX-M-228 WP_148044410.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-228 -> extended-spectrum class A beta-lactamase CTX-M-228
    blaCTX-M-229 WP_148044411.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-229 -> extended-spectrum class A beta-lactamase CTX-M-229
    blaCTX-M-23 WP_063860040.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-23 -> extended-spectrum class A beta-lactamase CTX-M-23
    blaCTX-M-230 WP_156404650.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-230 -> extended-spectrum class A beta-lactamase CTX-M-230
    blaCTX-M-231 WP_156404651.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-231 -> extended-spectrum class A beta-lactamase CTX-M-231
    blaCTX-M-232 WP_156404652.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-232 -> extended-spectrum class A beta-lactamase CTX-M-232
    blaCTX-M-233 WP_156404653.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-233 -> extended-spectrum class A beta-lactamase CTX-M-233
    blaCTX-M-234 WP_168247877.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-234 -> extended-spectrum class A beta-lactamase CTX-M-234
    blaCTX-M-235 WP_168247878.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-235 -> extended-spectrum class A beta-lactamase CTX-M-235
    blaCTX-M-236 WP_156658722.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-236 -> extended-spectrum class A beta-lactamase CTX-M-236
    blaCTX-M-237 WP_188331864.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-237 -> extended-spectrum class A beta-lactamase CTX-M-237
    blaCTX-M-238 WP_188331865.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-238 -> extended-spectrum class A beta-lactamase CTX-M-238
    blaCTX-M-239 WP_188331866.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-239 -> extended-spectrum class A beta-lactamase CTX-M-239
    blaCTX-M-24 WP_012579082.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-24 -> extended-spectrum class A beta-lactamase CTX-M-24
    blaCTX-M-240 WP_182496339.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-240 -> extended-spectrum class A beta-lactamase CTX-M-240
    blaCTX-M-241 WP_188331867.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-241 -> extended-spectrum class A beta-lactamase CTX-M-241
    blaCTX-M-242 WP_190259775.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-242 -> extended-spectrum class A beta-lactamase CTX-M-242
    blaCTX-M-243 WP_213994580.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-243 -> extended-spectrum class A beta-lactamase CTX-M-243
    blaCTX-M-244 WP_204376225.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-244 -> extended-spectrum class A beta-lactamase CTX-M-244
    blaCTX-M-245 WP_213994581.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-245 -> extended-spectrum class A beta-lactamase CTX-M-245
    blaCTX-M-246 WP_213994582.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-246 -> extended-spectrum class A beta-lactamase CTX-M-246
    blaCTX-M-25 WP_022542384.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-25 -> extended-spectrum class A beta-lactamase CTX-M-25
    blaCTX-M-251 WP_231869645.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-251 -> extended-spectrum class A beta-lactamase CTX-M-251
    blaCTX-M-252 WP_240067718.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-252 -> extended-spectrum class A beta-lactamase CTX-M-252
    blaCTX-M-26 WP_063860041.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-26 -> extended-spectrum class A beta-lactamase CTX-M-26
    blaCTX-M-27 WP_032277257.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-27 -> extended-spectrum class A beta-lactamase CTX-M-27
    blaCTX-M-28 WP_063860042.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-28 -> extended-spectrum class A beta-lactamase CTX-M-28
    blaCTX-M-29 WP_063860043.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-29 -> extended-spectrum class A beta-lactamase CTX-M-29
    blaCTX-M-3 WP_011091028.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-3 -> extended-spectrum class A beta-lactamase CTX-M-3
    blaCTX-M-30 WP_032490752.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-30 -> extended-spectrum class A beta-lactamase CTX-M-30
    blaCTX-M-31 WP_063860044.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-31 -> extended-spectrum class A beta-lactamase CTX-M-31
    blaCTX-M-32 WP_000239591.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-32 -> extended-spectrum class A beta-lactamase CTX-M-32
    blaCTX-M-33 WP_032490682.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-33 -> extended-spectrum class A beta-lactamase CTX-M-33
    blaCTX-M-34 WP_063860045.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-34 -> extended-spectrum class A beta-lactamase CTX-M-34
    blaCTX-M-35 WP_063860046.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-35 -> extended-spectrum class A beta-lactamase CTX-M-35
    blaCTX-M-36 WP_063860047.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-36 -> extended-spectrum class A beta-lactamase CTX-M-36
    blaCTX-M-37 WP_063860048.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-37 -> extended-spectrum class A beta-lactamase CTX-M-37
    blaCTX-M-38 WP_063860049.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-38 -> extended-spectrum class A beta-lactamase CTX-M-38
    blaCTX-M-39 WP_044702041.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-39 -> extended-spectrum class A beta-lactamase CTX-M-39
    blaCTX-M-4 WP_032489025.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-4 -> extended-spectrum class A beta-lactamase CTX-M-4
    blaCTX-M-40 WP_063860050.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-40 -> extended-spectrum class A beta-lactamase CTX-M-40
    blaCTX-M-41 WP_063860051.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-41 -> extended-spectrum class A beta-lactamase CTX-M-41
    blaCTX-M-42 WP_063860052.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-42 -> extended-spectrum class A beta-lactamase CTX-M-42
    blaCTX-M-43 WP_063860053.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-43 -> extended-spectrum class A beta-lactamase CTX-M-43
    blaCTX-M-44 WP_063860054.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-44 -> extended-spectrum class A beta-lactamase CTX-M-44
    blaCTX-M-46 WP_063860055.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-46 -> extended-spectrum class A beta-lactamase CTX-M-46
    blaCTX-M-47 WP_063860056.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-47 -> extended-spectrum class A beta-lactamase CTX-M-47
    blaCTX-M-48 WP_063860057.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-48 -> extended-spectrum class A beta-lactamase CTX-M-48
    blaCTX-M-49 WP_063860058.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-49 -> extended-spectrum class A beta-lactamase CTX-M-49
    blaCTX-M-5 WP_032072602.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-5 -> extended-spectrum class A beta-lactamase CTX-M-5
    blaCTX-M-50 WP_063860059.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-50 -> extended-spectrum class A beta-lactamase CTX-M-50
    blaCTX-M-51 WP_063860060.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-51 -> extended-spectrum class A beta-lactamase CTX-M-51
    blaCTX-M-52 WP_063860061.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-52 -> extended-spectrum class A beta-lactamase CTX-M-52
    blaCTX-M-53 WP_012579062.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-53 -> extended-spectrum class A beta-lactamase CTX-M-53
    blaCTX-M-54 WP_063860062.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-54 -> extended-spectrum class A beta-lactamase CTX-M-54
    blaCTX-M-55 WP_015387340.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-55 -> extended-spectrum class A beta-lactamase CTX-M-55
    blaCTX-M-56 WP_063860063.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-56 -> extended-spectrum class A beta-lactamase CTX-M-56
    blaCTX-M-58 WP_063860064.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-58 -> extended-spectrum class A beta-lactamase CTX-M-58
    blaCTX-M-59 WP_063860065.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-59 -> extended-spectrum class A beta-lactamase CTX-M-59
    blaCTX-M-6 WP_032489170.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-6 -> extended-spectrum class A beta-lactamase CTX-M-6
    blaCTX-M-60 WP_063860066.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-60 -> extended-spectrum class A beta-lactamase CTX-M-60
    blaCTX-M-61 WP_063860067.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-61 -> extended-spectrum class A beta-lactamase CTX-M-61
    blaCTX-M-62 WP_032493168.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-62 -> extended-spectrum class A beta-lactamase CTX-M-62
    blaCTX-M-63 WP_063860068.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-63 -> extended-spectrum class A beta-lactamase CTX-M-63
    blaCTX-M-64 WP_032492042.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-64 -> extended-spectrum class A beta-lactamase CTX-M-64
    blaCTX-M-65 WP_013188475.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-65 -> extended-spectrum class A beta-lactamase CTX-M-65
    blaCTX-M-66 WP_032491954.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-66 -> extended-spectrum class A beta-lactamase CTX-M-66
    blaCTX-M-67 WP_032492044.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-67 -> extended-spectrum class A beta-lactamase CTX-M-67
    blaCTX-M-68 WP_063860069.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-68 -> extended-spectrum class A beta-lactamase CTX-M-68
    blaCTX-M-69 WP_063860070.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-69 -> extended-spectrum class A beta-lactamase CTX-M-69
    blaCTX-M-7 WP_032489171.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-7 -> extended-spectrum class A beta-lactamase CTX-M-7
    blaCTX-M-71 WP_032492553.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-71 -> extended-spectrum class A beta-lactamase CTX-M-71
    blaCTX-M-72 WP_032491264.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-72 -> extended-spectrum class A beta-lactamase CTX-M-72
    blaCTX-M-73 WP_063860072.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-73 -> extended-spectrum class A beta-lactamase CTX-M-73
    blaCTX-M-74 WP_063860073.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-74 -> extended-spectrum class A beta-lactamase CTX-M-74
    blaCTX-M-75 WP_063860074.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-75 -> extended-spectrum class A beta-lactamase CTX-M-75
    blaCTX-M-76 WP_063860075.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-76 -> extended-spectrum class A beta-lactamase CTX-M-76
    blaCTX-M-77 WP_063860076.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-77 -> extended-spectrum class A beta-lactamase CTX-M-77
    blaCTX-M-78 WP_063860077.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-78 -> extended-spectrum class A beta-lactamase CTX-M-78
    blaCTX-M-79 WP_063860078.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-79 -> extended-spectrum class A beta-lactamase CTX-M-79
    blaCTX-M-8 WP_032489598.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-8 -> extended-spectrum class A beta-lactamase CTX-M-8
    blaCTX-M-80 WP_063860079.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-80 -> extended-spectrum class A beta-lactamase CTX-M-80
    blaCTX-M-81 WP_063860080.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-81 -> extended-spectrum class A beta-lactamase CTX-M-81
    blaCTX-M-82 WP_063860081.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-82 -> extended-spectrum class A beta-lactamase CTX-M-82
    blaCTX-M-83 WP_063860082.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-83 -> extended-spectrum class A beta-lactamase CTX-M-83
    blaCTX-M-84 WP_063860083.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-84 -> extended-spectrum class A beta-lactamase CTX-M-84
    blaCTX-M-85 WP_063860084.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-85 -> extended-spectrum class A beta-lactamase CTX-M-85
    blaCTX-M-86 WP_063860085.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-86 -> extended-spectrum class A beta-lactamase CTX-M-86
    blaCTX-M-87 WP_032492184.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-87 -> extended-spectrum class A beta-lactamase CTX-M-87
    blaCTX-M-88 WP_063860086.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-88 -> extended-spectrum class A beta-lactamase CTX-M-88
    blaCTX-M-89 WP_063860087.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-89 -> extended-spectrum class A beta-lactamase CTX-M-89
    blaCTX-M-9 WP_032489926.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-9 -> extended-spectrum class A beta-lactamase CTX-M-9
    blaCTX-M-90 WP_063860088.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-90 -> extended-spectrum class A beta-lactamase CTX-M-90
    blaCTX-M-91 WP_063860089.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-91 -> extended-spectrum class A beta-lactamase CTX-M-91
    blaCTX-M-92 WP_063860090.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-92 -> extended-spectrum class A beta-lactamase CTX-M-92
    blaCTX-M-93 WP_032495023.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-93 -> extended-spectrum class A beta-lactamase CTX-M-93
    blaCTX-M-94 WP_063860091.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-94 -> extended-spectrum class A beta-lactamase CTX-M-94
    blaCTX-M-95 WP_063860092.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-95 -> extended-spectrum class A beta-lactamase CTX-M-95
    blaCTX-M-96 WP_058670847.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-96 -> extended-spectrum class A beta-lactamase CTX-M-96
    blaCTX-M-97 WP_063860093.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-97 -> extended-spectrum class A beta-lactamase CTX-M-97
    blaCTX-M-98 WP_032495798.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-98 -> extended-spectrum class A beta-lactamase CTX-M-98
    blaCTX-M-99 WP_063860094.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-99 -> extended-spectrum class A beta-lactamase CTX-M-99
    blaDES-1 WP_063860095.1
        product_name:    class A extended-spectrum beta-lactamase DES-1 -> extended-spectrum class A beta-lactamase DES-1
    blaEC-13 WP_063860228.1
        product_name:    class C extended-spectrum beta-lactamase EC-13 -> extended-spectrum class C beta-lactamase EC-13
        pubmed_reference: <empty> -> 16801449
    blaEC-14 WP_063860233.1
        product_name:    class C extended-spectrum beta-lactamase EC-14 -> extended-spectrum class C beta-lactamase EC-14
        pubmed_reference: <empty> -> 16801449
    blaEC-15 WP_063610930.1
        product_name:    class C extended-spectrum beta-lactamase EC-15 -> extended-spectrum class C beta-lactamase EC-15
        pubmed_reference: <empty> -> 16801449
    blaEC-16 WP_063860248.1
        product_name:    class C extended-spectrum beta-lactamase EC-16 -> extended-spectrum class C beta-lactamase EC-16
        pubmed_reference: <empty> -> 16801449
    blaEC-18 WP_063860256.1
        product_name:    class C extended-spectrum beta-lactamase EC-18 -> extended-spectrum class C beta-lactamase EC-18
        pubmed_reference: <empty> -> 16801449
    blaEC-19 WP_063860263.1
        product_name:    class C extended-spectrum beta-lactamase EC-19 -> extended-spectrum class C beta-lactamase EC-19
        pubmed_reference: <empty> -> 16801449
    blaERP-1 WP_062743204.1
        product_name:    class A extended-spectrum beta-lactamase ERP-1 -> extended-spectrum class A beta-lactamase ERP-1
    blaFAR-1 WP_070064531.1
        product_name:    class A extended-spectrum beta-lactamase FAR-1 -> extended-spectrum class A beta-lactamase FAR-1
    blaGES-1 WP_013250881.1
        product_name:    class A extended-spectrum beta-lactamase GES-1 -> extended-spectrum class A beta-lactamase GES-1
    blaGES-10 WP_063860499.1
        product_name:    class A beta-lactamase GES-10 -> extended-spectrum class A beta-lactamase GES-10
        pubmed_reference: 19459951 -> 19459951,19738007
    blaGES-11 WP_001211000.1
        product_name:    class A extended-spectrum beta-lactamase GES-11 -> extended-spectrum class A beta-lactamase GES-11
        pubmed_reference: 19451292 -> 19451292,22908160
    blaGES-12 WP_063860500.1
        product_name:    class A beta-lactamase GES-12 -> extended-spectrum class A beta-lactamase GES-12
        pubmed_reference: 20805394 -> 20805394,22908160
    blaGES-13 WP_063860501.1
        product_name:    class A beta-lactamase GES-13 -> extended-spectrum class A beta-lactamase GES-13
    blaGES-14 WP_063860502.1
        pubmed_reference: 20805394 -> 19738007,20805394
    blaGES-15 WP_063860503.1
        product_name:    class A extended-spectrum beta-lactamase GES-15 -> extended-spectrum class A beta-lactamase GES-15
    blaGES-16 WP_063860504.1
        pubmed_reference: <empty> -> 19738007,29861147
    blaGES-17 WP_063860505.1
        product_name:    class A beta-lactamase GES-17 -> extended-spectrum class A beta-lactamase GES-17
        pubmed_reference: <empty> -> 19738007
    blaGES-18 WP_063860506.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase GES-18 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase GES-18
        pubmed_reference: 23114760 -> 19738007,23114760
    blaGES-19 WP_015059045.1
        product_name:    class A beta-lactamase GES-19 -> extended-spectrum class A beta-lactamase GES-19
        pubmed_reference: 22526300 -> 19738007,22526300
    blaGES-2 WP_045912044.1
        product_name:    class A extended-spectrum beta-lactamase GES-2 -> extended-spectrum class A beta-lactamase GES-2
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaGES-20 WP_015059046.1
        pubmed_reference: 22526300 -> 19738007,22526300
    blaGES-21 WP_063860507.1
        pubmed_reference: <empty> -> 19738007
    blaGES-22 WP_063860508.1
        pubmed_reference: 25267671 -> 25267671,27168312
    blaGES-23 WP_063860509.1
        product_name:    class A extended-spectrum beta-lactamase GES-23 -> extended-spectrum class A beta-lactamase GES-23
        pubmed_reference: <empty> -> 19738007
    blaGES-24 WP_059385191.1
        pubmed_reference: <empty> -> 19738007,30289383
    blaGES-25 WP_063860510.1
        product_name:    class A beta-lactamase GES-25 -> carbapenem-hydrolyzing class A beta-lactamase GES-25
        pubmed_reference: <empty> -> 19738007
        subclass:        CEPHALOSPORIN -> CARBAPENEM
    blaGES-26 WP_063860511.1
        product_name:    class A beta-lactamase GES-26 -> extended-spectrum class A beta-lactamase GES-26
        pubmed_reference: <empty> -> 19738007
    blaGES-28 WP_063860513.1
        product_name:    class A beta-lactamase GES-28 -> carbapenem-hydrolyzing class A beta-lactamase GES-28
        pubmed_reference: <empty> -> 19738007
        subclass:        CEPHALOSPORIN -> CARBAPENEM
    blaGES-3 WP_063860515.1
        product_name:    class A extended-spectrum beta-lactamase GES-3 -> extended-spectrum class A beta-lactamase GES-3
    blaGES-30 WP_063860516.1
        product_name:    class A beta-lactamase GES-30 -> carbapenem-hydrolyzing class A beta-lactamase GES-30
        pubmed_reference: <empty> -> 19738007
        subclass:        CEPHALOSPORIN -> CARBAPENEM
    blaGES-31 WP_063860517.1
        product_name:    class A beta-lactamase GES-31 -> extended-spectrum class A beta-lactamase GES-31
        pubmed_reference: <empty> -> 19738007
    blaGES-32 WP_069280709.1
        product_name:    class A beta-lactamase GES-32 -> extended-spectrum class A beta-lactamase GES-32
        pubmed_reference: <empty> -> 19738007
    blaGES-33 WP_085562419.1
        product_name:    class A beta-lactamase GES-33 -> carbapenem-hydrolyzing class A beta-lactamase GES-33
        pubmed_reference: <empty> -> 19738007
        subclass:        CEPHALOSPORIN -> CARBAPENEM
    blaGES-38 WP_122630826.1
        product_name:    class A beta-lactamase GES-38 -> extended-spectrum class A beta-lactamase GES-38
        pubmed_reference: <empty> -> 19738007
    blaGES-39 WP_122630827.1
        product_name:    class A beta-lactamase GES-39 -> carbapenem-hydrolyzing class A beta-lactamase GES-39
        pubmed_reference: <empty> -> 19738007
        subclass:        CEPHALOSPORIN -> CARBAPENEM
    blaGES-4 WP_063860518.1
        pubmed_reference: 15273099 -> 15273099,19738007
    blaGES-40 WP_123002100.1
        product_name:    class A beta-lactamase GES-40 -> carbapenem-hydrolyzing class A beta-lactamase GES-40
        pubmed_reference: <empty> -> 19738007
        subclass:        CEPHALOSPORIN -> CARBAPENEM
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        product_name:    class A beta-lactamase GES-41 -> carbapenem-hydrolyzing class A beta-lactamase GES-41
        pubmed_reference: <empty> -> 19738007
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        product_name:    class A beta-lactamase GES-44 -> extended-spectrum class A beta-lactamase GES-44
        pubmed_reference: <empty> -> 19738007
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        product_name:    class A beta-lactamase GES-45 -> extended-spectrum class A beta-lactamase GES-45
        pubmed_reference: <empty> -> 19738007
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        pubmed_reference: <empty> -> 19738007
    blaGES-48 WP_213994586.1
        pubmed_reference: <empty> -> 19738007
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        pubmed_reference: <empty> -> 19738007
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        pubmed_reference: 15135524 -> 15135524,19738007
    blaGES-50 WP_231869588.1
        pubmed_reference: <empty> -> 19738007
    blaGES-51 WP_200925854.1
        pubmed_reference: <empty> -> 19738007
    blaGES-6 WP_032490973.1
        pubmed_reference: 15135524 -> 15135524,19738007
    blaGES-7 WP_032490683.1
        product_name:    class A extended-spectrum beta-lactamase GES-7 -> extended-spectrum class A beta-lactamase GES-7
        pubmed_reference: 10952563 -> 10952563,19738007
    blaGES-8 WP_063860519.1
        product_name:    class A extended-spectrum beta-lactamase GES-8 -> extended-spectrum class A beta-lactamase GES-8
        pubmed_reference: 11679551 -> 11679551,19738007
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        product_name:    class A beta-lactamase GES-9 -> extended-spectrum class A beta-lactamase GES-9
        pubmed_reference: 16048994 -> 16048994,19738007
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        product_name:    class A broad-spectrum beta-lactamase GIL-1 -> broad-spectrum class A beta-lactamase GIL-1
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        pubmed_reference: <empty> -> 35257174
    blaKLUC-1 WP_061284984.1
        product_name:    class A extended-spectrum beta-lactamase KLUC-1 -> extended-spectrum class A beta-lactamase KLUC-1
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        product_name:    class A extended-spectrum beta-lactamase KLUC-2 -> extended-spectrum class A beta-lactamase KLUC-2
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        product_name:    class A extended-spectrum beta-lactamase KLUC-3 -> extended-spectrum class A beta-lactamase KLUC-3
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        product_name:    class A extended-spectrum beta-lactamase KLUC-4 -> extended-spectrum class A beta-lactamase KLUC-4
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        product_name:    class A extended-spectrum beta-lactamase KLUC-5 -> extended-spectrum class A beta-lactamase KLUC-5
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        subclass:        BETA-LACTAM -> CARBAPENEM
    blaKPC-104 WP_231869651.1
        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        subclass:        BETA-LACTAM -> CARBAPENEM
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        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-12 -> extended-spectrum class A beta-lactamase KPC-12
        pubmed_reference: <empty> -> 33595757
        subclass:        CARBAPENEM -> CEPHALOSPORIN
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        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-123 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-123
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        pubmed_reference: <empty> -> 25443891
    blaKPC-14 WP_063860636.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-14 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-14
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        pubmed_reference: <empty> -> 25360633
    blaKPC-16 WP_063860638.1
        pubmed_reference: <empty> -> 25634143
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        pubmed_reference: <empty> -> 25360633
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        pubmed_reference: <empty> -> 26719440,27161636
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        pubmed_reference: <empty> -> 28830804
    blaKPC-21 WP_063860711.1
        pubmed_reference: <empty> -> 30538682
    blaKPC-23 WP_111672911.1
        pubmed_reference: <empty> -> 30928562
    blaKPC-25 WP_065419571.1
        pubmed_reference: <empty> -> 34290688
    blaKPC-28 WP_072081992.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-28 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-28
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        pubmed_reference: <empty> -> 33809215
    blaKPC-31 WP_073668892.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-31 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-31
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        product_name:    inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-32 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-32
        pubmed_reference: <empty> -> 28031201
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-33 WP_101140102.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-33 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-33
        pubmed_reference: <empty> -> 28031201,33367577
    blaKPC-34 WP_109545044.1
        pubmed_reference: <empty> -> 29855588
    blaKPC-35 WP_111273852.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-35 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-35
        pubmed_reference: <empty> -> 30753572
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-36 WP_114699267.1
        pubmed_reference: <empty> -> 31593765
    blaKPC-39 WP_128268237.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-39 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-39
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        pubmed_reference: <empty> -> 31332070,33020157,35373297
    blaKPC-46 WP_148044421.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-46 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-46
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        pubmed_reference: <empty> -> 31733412
    blaKPC-49 WP_197749402.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-49 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-49
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        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-51 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-51
        pubmed_reference: <empty> -> 33920372
    blaKPC-52 WP_158208806.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-52 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-52
        pubmed_reference: <empty> -> 33920372
    blaKPC-53 WP_156649232.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-53 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-53
        pubmed_reference: <empty> -> 33106265
    blaKPC-55 WP_168247883.1
        pubmed_reference: <empty> -> 33133036
    blaKPC-57 WP_171476789.1
        product_name:    inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-57 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-57
        pubmed_reference: <empty> -> 32729059
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-61 WP_179284328.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-61 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-61
        pubmed_reference: <empty> -> 34228551
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-62 WP_204376229.1
        product_name:    class A beta-lactamase KPC-62 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-62
        pubmed_reference: <empty> -> 33775814
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-63 WP_204376230.1
        product_name:    class A beta-lactamase KPC-63 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-63
        pubmed_reference: <empty> -> 33775814
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-64 WP_204376231.1
        product_name:    class A beta-lactamase KPC-64 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-64
        pubmed_reference: <empty> -> 33775814
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-65 WP_204376232.1
        product_name:    class A beta-lactamase KPC-65 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-65
        pubmed_reference: <empty> -> 33775814
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-66 WP_188331871.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-66 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-66
    blaKPC-68 WP_210204468.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-68 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-68
    blaKPC-69 WP_210205486.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-69 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-69
    blaKPC-70 WP_210205477.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-70 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-70
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        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-71 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-71
    blaKPC-72 WP_188331872.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-72 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-72
    blaKPC-73 WP_188331873.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-73 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-73
    blaKPC-74 WP_188331874.1
        product_name:    inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-74 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-74
        pubmed_reference: <empty> -> 34484166
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-76 WP_194293135.1
        pubmed_reference: <empty> -> 34935416
    blaKPC-78 WP_197749403.1
        pubmed_reference: <empty> -> 34935416
    blaKPC-79 WP_197749404.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-79 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-79
        pubmed_reference: <empty> -> 34935416
    blaKPC-82 WP_202781289.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-82 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-82
    blaKPC-90 WP_219833567.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-90 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-90
        pubmed_reference: <empty> -> 35019766
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-92 WP_240067725.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase KPC-92 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-92
    blaKPC-94 WP_219804981.1
        product_name:    class A beta-lactamase KPC-94 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-94
        pubmed_reference: <empty> -> 35038557
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-95 WP_219795346.1
        product_name:    class A beta-lactamase KPC-95 -> inhibitor-resistant extended-spectrum class A beta-lactamase KPC-95
        pubmed_reference: <empty> -> 35038557
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaLRG-1 WP_063860827.1
        product_name:    class A extended-spectrum beta-lactamase LRG-1 -> extended-spectrum class A beta-lactamase LRG-1
    blaLUT-1 WP_010798607.1
        product_name:    class A extended-spectrum beta-lactamase LUT-1 -> extended-spectrum class A beta-lactamase LUT-1
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        pubmed_reference: <empty> -> 33920372
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        genbank_nucleotide_accession: KJ746495.1 -> KJ746495.3
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        product_name:    class C extended-spectrum beta-lactamase OCH-1 -> extended-spectrum class C beta-lactamase OCH-1
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        product_name:    class C extended-spectrum beta-lactamase OCH-2 -> extended-spectrum class C beta-lactamase OCH-2
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        product_name:    class C extended-spectrum beta-lactamase OCH-3 -> extended-spectrum class C beta-lactamase OCH-3
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        product_name:    class C extended-spectrum beta-lactamase OCH-4 -> extended-spectrum class C beta-lactamase OCH-4
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        product_name:    class C extended-spectrum beta-lactamase OCH-5 -> extended-spectrum class C beta-lactamase OCH-5
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        product_name:    class C extended-spectrum beta-lactamase OCH-6 -> extended-spectrum class C beta-lactamase OCH-6
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        product_name:    class C extended-spectrum beta-lactamase OCH-7 -> extended-spectrum class C beta-lactamase OCH-7
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        product_name:    class C extended-spectrum beta-lactamase OCH-8 -> extended-spectrum class C beta-lactamase OCH-8
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        product_name:    class A extended-spectrum beta-lactamase OHIO-1 -> extended-spectrum class A beta-lactamase OHIO-1
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-1 -> broad-spectrum class A beta-lactamase OKP-A-1
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-10 -> broad-spectrum class A beta-lactamase OKP-A-10
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-11 -> broad-spectrum class A beta-lactamase OKP-A-11
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-12 -> broad-spectrum class A beta-lactamase OKP-A-12
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-13 -> broad-spectrum class A beta-lactamase OKP-A-13
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-14 -> broad-spectrum class A beta-lactamase OKP-A-14
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-15 -> broad-spectrum class A beta-lactamase OKP-A-15
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-16 -> broad-spectrum class A beta-lactamase OKP-A-16
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-17 -> broad-spectrum class A beta-lactamase OKP-A-17
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-2 -> broad-spectrum class A beta-lactamase OKP-A-2
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-3 -> broad-spectrum class A beta-lactamase OKP-A-3
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-4 -> broad-spectrum class A beta-lactamase OKP-A-4
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-5 -> broad-spectrum class A beta-lactamase OKP-A-5
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-6 -> broad-spectrum class A beta-lactamase OKP-A-6
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-7 -> broad-spectrum class A beta-lactamase OKP-A-7
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-8 -> broad-spectrum class A beta-lactamase OKP-A-8
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        product_name:    class A broad-spectrum beta-lactamase OKP-A-9 -> broad-spectrum class A beta-lactamase OKP-A-9
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        product_name:    class A broad-spectrum beta-lactamase OKP-B-1 -> broad-spectrum class A beta-lactamase OKP-B-1
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        product_name:    class A broad-spectrum beta-lactamase OKP-B-10 -> broad-spectrum class A beta-lactamase OKP-B-10
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        product_name:    class A broad-spectrum beta-lactamase OKP-B-11 -> broad-spectrum class A beta-lactamase OKP-B-11
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        product_name:    class A broad-spectrum beta-lactamase OKP-B-13 -> broad-spectrum class A beta-lactamase OKP-B-13
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        product_name:    class A broad-spectrum beta-lactamase OKP-B-17 -> broad-spectrum class A beta-lactamase OKP-B-17
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        product_name:    class A broad-spectrum beta-lactamase OKP-B-18 -> broad-spectrum class A beta-lactamase OKP-B-18
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        product_name:    class A broad-spectrum beta-lactamase OKP-B-19 -> broad-spectrum class A beta-lactamase OKP-B-19
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        product_name:    class A broad-spectrum beta-lactamase OKP-B-2 -> broad-spectrum class A beta-lactamase OKP-B-2
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        product_name:    class A broad-spectrum beta-lactamase OKP-B-20 -> broad-spectrum class A beta-lactamase OKP-B-20
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        product_name:    class A broad-spectrum beta-lactamase OKP-B-21 -> broad-spectrum class A beta-lactamase OKP-B-21
    blaOKP-B-22 WP_122543028.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-22 -> broad-spectrum class A beta-lactamase OKP-B-22
    blaOKP-B-23 WP_023318187.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-23 -> broad-spectrum class A beta-lactamase OKP-B-23
    blaOKP-B-24 WP_156404657.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-24 -> broad-spectrum class A beta-lactamase OKP-B-24
    blaOKP-B-3 WP_063860916.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-3 -> broad-spectrum class A beta-lactamase OKP-B-3
    blaOKP-B-34 WP_087771722.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-34 -> broad-spectrum class A beta-lactamase OKP-B-34
    blaOKP-B-36 WP_060655783.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-36 -> broad-spectrum class A beta-lactamase OKP-B-36
    blaOKP-B-4 WP_063860917.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-4 -> broad-spectrum class A beta-lactamase OKP-B-4
    blaOKP-B-40 WP_114508147.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-40 -> broad-spectrum class A beta-lactamase OKP-B-40
    blaOKP-B-41 WP_049003700.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-41 -> broad-spectrum class A beta-lactamase OKP-B-41
    blaOKP-B-45 WP_048324114.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-45 -> broad-spectrum class A beta-lactamase OKP-B-45
    blaOKP-B-5 WP_063860923.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-5 -> broad-spectrum class A beta-lactamase OKP-B-5
    blaOKP-B-6 WP_004205995.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-6 -> broad-spectrum class A beta-lactamase OKP-B-6
    blaOKP-B-7 WP_057215100.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-7 -> broad-spectrum class A beta-lactamase OKP-B-7
    blaOKP-B-8 WP_017900346.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-8 -> broad-spectrum class A beta-lactamase OKP-B-8
    blaOKP-B-9 WP_063860931.1
        product_name:    class A broad-spectrum beta-lactamase OKP-B-9 -> broad-spectrum class A beta-lactamase OKP-B-9
    blaOKP-C-1 WP_136034107.1
        product_name:    class A broad-spectrum beta-lactamase OKP-C-1 -> broad-spectrum class A beta-lactamase OKP-C-1
    blaOKP-D-1 WP_080897395.1
        product_name:    class A broad-spectrum beta-lactamase OKP-D-1 -> broad-spectrum class A beta-lactamase OKP-D-1
    blaORN-1 WP_004862397.1
        product_name:    class A broad-spectrum beta-lactamase ORN-1 -> broad-spectrum class A beta-lactamase ORN-1
    blaOXA-1011 WP_211816370.1
        pubmed_reference: <empty> -> 35231657
    blaOXA-1040 WP_231869647.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1051 WP_240067731.1
        product_name:    class D beta-lactamase OXA-1051 -> OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-1051
    blaOXA-1081 WP_242934101.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1095 WP_242934109.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-11 WP_063860939.1
        product_name:    OXA-10 family class D extended-spectrum beta-lactamase OXA-11 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-11
    blaOXA-114a WP_054505840.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-114a -> class D beta-lactamase OXA-114a
    blaOXA-14 WP_064056056.1
        product_name:    OXA-10 family oxacillin-hydrolyzing class D extended-spectrum beta-lactamase OXA-14 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-14
    blaOXA-141 WP_058177653.1
        product_name:    OXA-2 family class D extended-spectrum beta-lactamase OXA-141 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-141
    blaOXA-142 WP_063861041.1
        product_name:    OXA-10 family oxacillin-hydrolyzing class D extended-spectrum beta-lactamase OXA-142 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-142
    blaOXA-145 WP_063861043.1
        product_name:    OXA-10 family class D extended-spectrum beta-lactamase OXA-145 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-145
    blaOXA-147 WP_063861045.1
        product_name:    OXA-10 family class D extended-spectrum beta-lactamase OXA-147 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-147
    blaOXA-15 WP_063861048.1
        product_name:    OXA-2 family class D extended-spectrum beta-lactamase OXA-15 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-15
    blaOXA-161 WP_063861101.1
        product_name:    OXA-2 family class D extended-spectrum beta-lactamase OXA-161 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-161
    blaOXA-163 WP_063131934.1
        product_name:    OXA-48 family class D extended-spectrum beta-lactamase OXA-163 -> OXA-48 family extended-spectrum class D beta-lactamase OXA-163
    blaOXA-17 WP_032491804.1
        product_name:    OXA-10 family oxacillin-hydrolyzing class D extended-spectrum beta-lactamase OXA-17 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-17
    blaOXA-18 WP_063861237.1
        product_name:    class D extended-spectrum beta-lactamase OXA-18 -> extended-spectrum class D beta-lactamase OXA-18
    blaOXA-184 WP_002872405.1
        product_name:    class D beta-lactamase OXA-184 -> OXA-184 family class D beta-lactamase OXA-184
    blaOXA-19 WP_063861309.1
        product_name:    OXA-10 family class D extended-spectrum beta-lactamase OXA-19 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-19
    blaOXA-207 WP_057689930.1
        pubmed_reference: <empty> -> 24890588
    blaOXA-226 WP_063861826.1
        product_name:    OXA-2 family class D extended-spectrum beta-lactamase OXA-226 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-226
    blaOXA-23 WP_001046004.1
        product_name:    carbapenem-hydrolyzing class D beta-lactamase OXA-23 -> OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-23
    blaOXA-233 WP_063862149.1
        pubmed_reference: <empty> -> 33382875
    blaOXA-24 WP_012754353.1
        product_name:    carbapenem-hydrolyzing class D beta-lactamase OXA-24 -> OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-24
    blaOXA-274 WP_004725235.1
        product_name:    class D beta-lactamase OXA-274 -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-274
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-275 WP_004816501.1
        product_name:    OXA-274 family class D beta-lactamase OXA-275 -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-275
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-28 WP_032489753.1
        product_name:    OXA-10 family class D extended-spectrum beta-lactamase OXA-28 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-28
    blaOXA-286 WP_004657207.1
        product_name:    class D beta-lactamase OXA-286 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-286
        pubmed_reference: <empty> -> 30247543
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-287 WP_032865068.1
        product_name:    OXA-286 family class D beta-lactamase OXA-287 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-287
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-288 WP_005201559.1
        product_name:    OXA-286 family class D beta-lactamase OXA-288 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-288
        pubmed_reference: 24277043 -> 24277043,30247543
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-291 WP_005185807.1
        product_name:    OXA-286 family class D beta-lactamase OXA-291 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-291
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-292 WP_005209448.1
        product_name:    OXA-286 family class D beta-lactamase OXA-292 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-292
        pubmed_reference: 24277043 -> 24277043,30247543
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-293 WP_032877719.1
        product_name:    OXA-286 family class D beta-lactamase OXA-293 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-293
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-302 WP_005238189.1
        product_name:    OXA-286 family class D beta-lactamase OXA-302 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-302
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-303 WP_005317413.1
        product_name:    OXA-286 family class D beta-lactamase OXA-303 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-303
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-306 WP_005297518.1
        product_name:    OXA-286 family class D beta-lactamase OXA-306 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-306
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-307 WP_032879257.1
        product_name:    OXA-286 family class D beta-lactamase OXA-307 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-307
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-31 WP_032490053.1
        product_name:    OXA-1 family class D extended-spectrum beta-lactamase OXA-31 -> OXA-1 family extended-spectrum class D beta-lactamase OXA-31
    blaOXA-32 WP_063862613.1
        product_name:    OXA-2 family class D extended-spectrum beta-lactamase OXA-32 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-32
    blaOXA-35 WP_063862720.1
        product_name:    OXA-10 family oxacillin-hydrolyzing class D extended-spectrum beta-lactamase OXA-35 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-35
    blaOXA-364 WP_063862734.1
        product_name:    class D beta-lactamase OXA-364 -> OXA-364 family class D beta-lactamase OXA-364
    blaOXA-372 WP_063862739.1
        pubmed_reference: <empty> -> 26126492
    blaOXA-405 WP_063862762.1
        product_name:    OXA-48 family class D extended-spectrum beta-lactamase OXA-405 -> OXA-48 family extended-spectrum class D beta-lactamase OXA-405
    blaOXA-45 WP_032490761.1
        product_name:    oxacillin-hydrolyzing class D extended-spectrum beta-lactamase OXA-45 -> extended-spectrum class D beta-lactamase OXA-45
    blaOXA-455 WP_054428802.1
        product_name:    OXA-364 family oxacillin-hydrolyzing class D beta-lactamase OXA-455 -> OXA-364 family class D beta-lactamase OXA-455
    blaOXA-48 WP_015059991.1
        product_name:    carbapenem-hydrolyzing class D beta-lactamase OXA-48 -> OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-48
    blaOXA-513 WP_063864194.1
        product_name:    OXA-364 family oxacillin-hydrolyzing class D beta-lactamase OXA-513 -> OXA-364 family class D beta-lactamase OXA-513
    blaOXA-519 WP_094009808.1
        pubmed_reference: <empty> -> 29866857
    blaOXA-53 WP_063864223.1
        product_name:    OXA-2 family class D extended-spectrum beta-lactamase OXA-53 -> OXA-2 family extended-spectrum class D beta-lactamase OXA-53
    blaOXA-539 WP_071593233.1
        product_name:    OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-539 -> OXA-2 family inhibitor-resistant extended-spectrum class D beta-lactamase OXA-539
        pubmed_reference: <empty> -> 28674059
    blaOXA-653 WP_087554513.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-655 WP_122630842.1
        pubmed_reference: <empty> -> 30397053
    blaOXA-665 WP_016657654.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-666 WP_092689909.1
        product_name:    carbapenem-hydrolyzing class D beta-lactamase OXA-666 -> class D beta-lactamase OXA-666
        pubmed_reference: <empty> -> 30247543
    blaOXA-667 WP_096735335.1
        product_name:    OXA-274 family class D beta-lactamase OXA-667 -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-667
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-668 WP_034612711.1
        product_name:    OXA-274 family class D beta-lactamase OXA-668 -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-668
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-669 WP_056517622.1
        product_name:    OXA-274 family class D beta-lactamase OXA-669 -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase OXA-669
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-670 WP_016651348.1
        product_name:    OXA-286 family class D beta-lactamase OXA-670 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-670
        pubmed_reference: <empty> -> 30247543
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-671 WP_081401608.1
        product_name:    OXA-286 family class D beta-lactamase OXA-671 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-671
        pubmed_reference: <empty> -> 30247543
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-672 WP_023271137.1
        product_name:    OXA-286 family class D beta-lactamase OXA-672 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-672
        pubmed_reference: <empty> -> 30247543
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-673 WP_016162389.1
        product_name:    OXA-286 family class D beta-lactamase OXA-673 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-673
        pubmed_reference: <empty> -> 30247543
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-674 WP_081406929.1
        product_name:    OXA-286 family class D beta-lactamase OXA-674 -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase OXA-674
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-676 WP_122630858.1
        product_name:    OXA-10 family class D beta-lactamase OXA-676 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-676
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-679 WP_122634439.1
        product_name:    carbapenem-hydrolyzing class D beta-lactamase OXA-679 -> OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-679
        pubmed_reference: <empty> -> 30844059
    blaOXA-681 WP_122630881.1
        product_name:    OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-681 -> OXA-2 family inhibitor-resistant extended-spectrum class D beta-lactamase OXA-681
    blaOXA-727 WP_114272532.1
        product_name:    class D beta-lactamase OXA-727 -> OXA-727 family class D beta-lactamase OXA-727
    blaOXA-736 WP_122630855.1
        product_name:    OXA-10 family class D beta-lactamase OXA-736 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-736
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-806 WP_136512097.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-807 WP_136512098.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-808 WP_136512099.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-809 WP_136512100.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-810 WP_136512101.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-811 WP_136512102.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-812 WP_034688190.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-813 WP_005404206.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-814 WP_005405613.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-815 WP_111280830.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-816 WP_026444036.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-817 WP_075040046.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-818 WP_034670108.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-830 WP_152315468.1
        product_name:    class D extended-spectrum beta-lactamase OXA-830 -> extended-spectrum class D beta-lactamase OXA-830
    blaOXA-893 WP_194293137.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-897 WP_164461290.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-911 WP_168247884.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-935 WP_141989064.1
        product_name:    OXA-10 family class D beta-lactamase OXA-935 -> OXA-10 family extended-spectrum class D beta-lactamase OXA-935
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-966 WP_005405099.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-967 WP_231869594.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-968 WP_231869595.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-969 WP_231869596.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXY-1-1 WP_014228247.1
        product_name:    class A extended-spectrum beta-lactamase OXY-1-1 -> extended-spectrum class A beta-lactamase OXY-1-1
    blaOXY-1-2 WP_025107110.1
        product_name:    class A extended-spectrum beta-lactamase OXY-1-2 -> extended-spectrum class A beta-lactamase OXY-1-2
    blaOXY-1-3 WP_063864545.1
        product_name:    class A extended-spectrum beta-lactamase OXY-1-3 -> extended-spectrum class A beta-lactamase OXY-1-3
    blaOXY-1-4 WP_049101515.1
        product_name:    class A extended-spectrum beta-lactamase OXY-1-4 -> extended-spectrum class A beta-lactamase OXY-1-4
    blaOXY-1-6 WP_063864546.1
        product_name:    class A extended-spectrum beta-lactamase OXY-1-6 -> extended-spectrum class A beta-lactamase OXY-1-6
    blaOXY-2-1 WP_032727905.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-1 -> extended-spectrum class A beta-lactamase OXY-2-1
    blaOXY-2-10 WP_063864547.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-10 -> extended-spectrum class A beta-lactamase OXY-2-10
    blaOXY-2-11 WP_004111091.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-11 -> extended-spectrum class A beta-lactamase OXY-2-11
    blaOXY-2-12 WP_063864548.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-12 -> extended-spectrum class A beta-lactamase OXY-2-12
    blaOXY-2-13 WP_063864549.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-13 -> extended-spectrum class A beta-lactamase OXY-2-13
    blaOXY-2-14 WP_063842752.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-14 -> extended-spectrum class A beta-lactamase OXY-2-14
    blaOXY-2-15 WP_063864550.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-15 -> extended-spectrum class A beta-lactamase OXY-2-15
    blaOXY-2-2 WP_023329386.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-2 -> extended-spectrum class A beta-lactamase OXY-2-2
    blaOXY-2-3 WP_063864551.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-3 -> extended-spectrum class A beta-lactamase OXY-2-3
    blaOXY-2-4 WP_004099854.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-4 -> extended-spectrum class A beta-lactamase OXY-2-4
    blaOXY-2-5 WP_063842759.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-5 -> extended-spectrum class A beta-lactamase OXY-2-5
    blaOXY-2-6 WP_063864552.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-6 -> extended-spectrum class A beta-lactamase OXY-2-6
    blaOXY-2-7 WP_017146441.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-7 -> extended-spectrum class A beta-lactamase OXY-2-7
    blaOXY-2-8 WP_053064676.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-8 -> extended-spectrum class A beta-lactamase OXY-2-8
    blaOXY-2-9 WP_063864553.1
        product_name:    class A extended-spectrum beta-lactamase OXY-2-9 -> extended-spectrum class A beta-lactamase OXY-2-9
    blaOXY-3-1 WP_063864554.1
        product_name:    class A extended-spectrum beta-lactamase OXY-3-1 -> extended-spectrum class A beta-lactamase OXY-3-1
    blaOXY-4-1 WP_004130122.1
        product_name:    class A extended-spectrum beta-lactamase OXY-4-1 -> extended-spectrum class A beta-lactamase OXY-4-1
    blaOXY-5-1 WP_063864555.1
        product_name:    class A extended-spectrum beta-lactamase OXY-5-1 -> extended-spectrum class A beta-lactamase OXY-5-1
    blaOXY-5-2 WP_009652647.1
        product_name:    class A extended-spectrum beta-lactamase OXY-5-2 -> extended-spectrum class A beta-lactamase OXY-5-2
    blaOXY-6-1 WP_063864556.1
        product_name:    class A extended-spectrum beta-lactamase OXY-6-1 -> extended-spectrum class A beta-lactamase OXY-6-1
    blaOXY-6-2 WP_063864557.1
        product_name:    class A extended-spectrum beta-lactamase OXY-6-2 -> extended-spectrum class A beta-lactamase OXY-6-2
    blaOXY-6-3 WP_063864558.1
        product_name:    class A extended-spectrum beta-lactamase OXY-6-3 -> extended-spectrum class A beta-lactamase OXY-6-3
    blaOXY-6-4 WP_004137840.1
        product_name:    class A extended-spectrum beta-lactamase OXY-6-4 -> extended-spectrum class A beta-lactamase OXY-6-4
    blaPDC-2 WP_063864573.1
        product_name:    class C extended-spectrum beta-lactamase PDC-2 -> extended-spectrum class C beta-lactamase PDC-2
    blaPDC-221 WP_100931731.1
        pubmed_reference: 29149337 -> 29149337,34930034
    blaPDC-223 WP_100931733.1
        pubmed_reference: 29149337 -> 29149337,34930034
    blaPDC-270 WP_109791203.1
        pubmed_reference: <empty> -> 31636072
    blaPDC-3 WP_003121934.1
        product_name:    class C extended-spectrum beta-lactamase PDC-3 -> extended-spectrum class C beta-lactamase PDC-3
    blaPDC-4 WP_063864580.1
        product_name:    class C extended-spectrum beta-lactamase PDC-4 -> extended-spectrum class C beta-lactamase PDC-4
    blaPDC-477 WP_213994605.1
        product_name:    class C beta-lactamase PDC-477 -> inhibitor-resistant class C beta-lactamase PDC-477
        pubmed_reference: <empty> -> 34930034
    blaPDC-478 WP_213994606.1
        product_name:    class C beta-lactamase PDC-478 -> inhibitor-resistant class C beta-lactamase PDC-478
        pubmed_reference: <empty> -> 34930034
    blaPDC-482 WP_213994610.1
        product_name:    class C beta-lactamase PDC-482 -> inhibitor-resistant class C beta-lactamase PDC-482
        pubmed_reference: <empty> -> 34930034
    blaPDC-483 WP_213994611.1
        product_name:    class C beta-lactamase PDC-483 -> inhibitor-resistant class C beta-lactamase PDC-483
        pubmed_reference: <empty> -> 34930034
    blaPDC-5 WP_003119095.1
        product_name:    class C extended-spectrum beta-lactamase PDC-5 -> extended-spectrum class C beta-lactamase PDC-5
    blaPDC-500 WP_231873784.1
        pubmed_reference: <empty> -> 31636072
    blaPDC-510 WP_240067745.1
        product_name:    class C beta-lactamase PDC-510 -> inhibitor-resistant class C beta-lactamase PDC-510
        pubmed_reference: <empty> -> 31636072
    blaPER-1 WP_001100753.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase PER-1 -> inhibitor-resistant extended-spectrum class A beta-lactamase PER-1
    blaPER-10 WP_001100752.1
        product_name:    class A extended-spectrum beta-lactamase PER-10 -> extended-spectrum class A beta-lactamase PER-10
    blaPER-11 WP_104009831.1
        product_name:    class A extended-spectrum beta-lactamase PER-11 -> extended-spectrum class A beta-lactamase PER-11
    blaPER-12 WP_096865225.1
        product_name:    class A extended-spectrum beta-lactamase PER-12 -> extended-spectrum class A beta-lactamase PER-12
    blaPER-13 WP_136512105.1
        product_name:    class A extended-spectrum beta-lactamase PER-13 -> extended-spectrum class A beta-lactamase PER-13
    blaPER-14 WP_156404659.1
        product_name:    class A extended-spectrum beta-lactamase PER-14 -> extended-spectrum class A beta-lactamase PER-14
    blaPER-15 WP_168247906.1
        product_name:    class A extended-spectrum beta-lactamase PER-15 -> extended-spectrum class A beta-lactamase PER-15
    blaPER-16 WP_202089433.1
        product_name:    class A extended-spectrum beta-lactamase PER-16 -> extended-spectrum class A beta-lactamase PER-16
    blaPER-2 WP_032491907.1
        product_name:    class A extended-spectrum beta-lactamase PER-2 -> extended-spectrum class A beta-lactamase PER-2
        pubmed_reference: 8851581 -> 17438050,8851581
    blaPER-3 WP_049637349.1
        product_name:    class A extended-spectrum beta-lactamase PER-3 -> extended-spectrum class A beta-lactamase PER-3
        pubmed_reference: 21968366 -> 21968366,26674256
    blaPER-4 WP_063864593.1
        product_name:    class A extended-spectrum beta-lactamase PER-4 -> extended-spectrum class A beta-lactamase PER-4
    blaPER-5 WP_063864594.1
        product_name:    class A extended-spectrum beta-lactamase PER-5 -> extended-spectrum class A beta-lactamase PER-5
    blaPER-6 WP_063864595.1
        product_name:    class A extended-spectrum beta-lactamase PER-6 -> extended-spectrum class A beta-lactamase PER-6
    blaPER-7 WP_032495440.1
        product_name:    class A extended-spectrum beta-lactamase PER-7 -> extended-spectrum class A beta-lactamase PER-7
    blaPER-8 WP_063864596.1
        product_name:    class A extended-spectrum beta-lactamase PER-8 -> extended-spectrum class A beta-lactamase PER-8
    blaPER-9 WP_063864597.1
        product_name:    class A extended-spectrum beta-lactamase PER-9 -> extended-spectrum class A beta-lactamase PER-9
    blaPLA-1 WP_032699754.1
        product_name:    class A broad-spectrum beta-lactamase PLA-1 -> broad-spectrum class A beta-lactamase PLA-1
    blaPME-1 WP_063864599.1
        product_name:    class A extended-spectrum beta-lactamase PME-1 -> extended-spectrum class A beta-lactamase PME-1
        pubmed_reference: <empty> -> 21402845
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaRAHN-1 WP_063864600.1
        product_name:    class A extended-spectrum beta-lactamase RAHN-1 -> extended-spectrum class A beta-lactamase RAHN-1
    blaRAHN-2 WP_063864601.1
        product_name:    class A extended-spectrum beta-lactamase RAHN-2 -> extended-spectrum class A beta-lactamase RAHN-2
    blaRASA-1 WP_064964747.1
        product_name:    class A extended-spectrum beta-lactamase RASA-1 -> extended-spectrum class A beta-lactamase RASA-1
    blaROB-1 WP_005618523.1
        product_name:    cephalosporin-hydrolyzing class A beta-lactamase ROB-1 -> broad-spectrum class A beta-lactamase ROB-1
    blaROB-10 WP_116743769.1
        product_name:    class A beta-lactamase ROB-10 -> broad-spectrum class A beta-lactamase ROB-10
    blaROB-11 WP_132995818.1
        product_name:    class A beta-lactamase ROB-11 -> broad-spectrum class A beta-lactamase ROB-11
    blaROB-12 WP_213994612.1
        product_name:    class A beta-lactamase ROB-12 -> broad-spectrum class A beta-lactamase ROB-12
    blaROB-13 WP_015431537.1
        allele:          blaROB-2 -> blaROB-13
        hierarchy_node:  blaROB-2 -> blaROB-13
        product_name:    class A beta-lactamase ROB-2 -> broad-spectrum class A beta-lactamase ROB-13
    blaROB-2 WP_172693371.1
        allele:          blaROB-9 -> blaROB-2
        hierarchy_node:  blaROB-9 -> blaROB-2
        product_name:    class A beta-lactamase ROB-9 -> extended-spectrum class A beta-lactamase ROB-2
        pubmed_reference: <empty> -> 30561662
    blaROB-3 WP_075606311.1
        product_name:    class A beta-lactamase ROB-3 -> broad-spectrum class A beta-lactamase ROB-3
    blaROB-4 WP_078318620.1
        product_name:    class A beta-lactamase ROB-4 -> broad-spectrum class A beta-lactamase ROB-4
    blaROB-5 WP_103034696.1
        product_name:    class A beta-lactamase ROB-5 -> broad-spectrum class A beta-lactamase ROB-5
    blaROB-6 WP_179284390.1
        product_name:    class A beta-lactamase ROB-6 -> broad-spectrum class A beta-lactamase ROB-6
    blaROB-7 WP_179284391.1
        product_name:    class A beta-lactamase ROB-7 -> broad-spectrum class A beta-lactamase ROB-7
    blaROB-8 WP_179284392.1
        product_name:    class A beta-lactamase ROB-8 -> broad-spectrum class A beta-lactamase ROB-8
    blaRUB-1 WP_072186106.1
        product_name:    class A broad-spectrum beta-lactamase RUB-1 -> broad-spectrum class A beta-lactamase RUB-1
    blaSED-1 WP_063864602.1
        product_name:    class A broad-spectrum beta-lactamase SED-1 -> broad-spectrum class A beta-lactamase SED-1
    blaSFO-1 WP_032489477.1
        product_name:    class A extended-spectrum beta-lactamase SFO-1 -> extended-spectrum class A beta-lactamase SFO-1
    blaSGM-1 WP_009821475.1
        product_name:    class A extended-spectrum beta-lactamase SGM-1 -> extended-spectrum class A beta-lactamase SGM-1
    blaSHV-1 WP_001620095.1
        product_name:    class A broad-spectrum beta-lactamase SHV-1 -> broad-spectrum class A beta-lactamase SHV-1
    blaSHV-100 WP_063864604.1
        product_name:    class A broad-spectrum beta-lactamase SHV-100 -> broad-spectrum class A beta-lactamase SHV-100
    blaSHV-101 WP_063864605.1
        product_name:    class A broad-spectrum beta-lactamase SHV-101 -> broad-spectrum class A beta-lactamase SHV-101
    blaSHV-102 WP_063864606.1
        product_name:    class A extended-spectrum beta-lactamase SHV-102 -> extended-spectrum class A beta-lactamase SHV-102
    blaSHV-103 WP_063864607.1
        product_name:    class A broad-spectrum beta-lactamase SHV-103 -> broad-spectrum class A beta-lactamase SHV-103
    blaSHV-104 WP_032492114.1
        product_name:    class A broad-spectrum beta-lactamase SHV-104 -> broad-spectrum class A beta-lactamase SHV-104
    blaSHV-105 WP_063864608.1
        product_name:    class A extended-spectrum beta-lactamase SHV-105 -> extended-spectrum class A beta-lactamase SHV-105
    blaSHV-106 WP_063864609.1
        product_name:    class A extended-spectrum beta-lactamase SHV-106 -> extended-spectrum class A beta-lactamase SHV-106
    blaSHV-107 WP_063864610.1
        product_name:    inhibitor-resistant class A broad-spectrum beta-lactamase SHV-107 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-107
    blaSHV-108 WP_063864611.1
        product_name:    class A broad-spectrum beta-lactamase SHV-108 -> broad-spectrum class A beta-lactamase SHV-108
        pubmed_reference: <empty> -> 11036038
    blaSHV-109 WP_063864612.1
        product_name:    class A broad-spectrum beta-lactamase SHV-109 -> broad-spectrum class A beta-lactamase SHV-109
    blaSHV-11 WP_004176269.1
        product_name:    class A broad-spectrum beta-lactamase SHV-11 -> broad-spectrum class A beta-lactamase SHV-11
    blaSHV-111 WP_063864614.1
        product_name:    class A broad-spectrum beta-lactamase SHV-111 -> broad-spectrum class A beta-lactamase SHV-111
    blaSHV-115 WP_156404661.1
        product_name:    class A extended-spectrum beta-lactamase SHV-115 -> extended-spectrum class A beta-lactamase SHV-115
        pubmed_reference: <empty> -> 27656166
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-12 WP_002904004.1
        product_name:    class A extended-spectrum beta-lactamase SHV-12 -> extended-spectrum class A beta-lactamase SHV-12
    blaSHV-120 WP_063864616.1
        product_name:    class A extended-spectrum beta-lactamase SHV-120 -> extended-spectrum class A beta-lactamase SHV-120
    blaSHV-128 WP_063864618.1
        product_name:    class A extended-spectrum beta-lactamase SHV-128 -> extended-spectrum class A beta-lactamase SHV-128
    blaSHV-129 WP_032494802.1
        product_name:    class A extended-spectrum beta-lactamase SHV-129 -> extended-spectrum class A beta-lactamase SHV-129
    blaSHV-13 WP_063864619.1
        product_name:    class A extended-spectrum beta-lactamase SHV-13 -> extended-spectrum class A beta-lactamase SHV-13
    blaSHV-133 WP_063864621.1
        product_name:    class A broad-spectrum beta-lactamase SHV-133 -> broad-spectrum class A beta-lactamase SHV-133
    blaSHV-134 WP_063864622.1
        product_name:    class A extended-spectrum beta-lactamase SHV-134 -> extended-spectrum class A beta-lactamase SHV-134
    blaSHV-135 WP_063864623.1
        product_name:    class A broad-spectrum beta-lactamase SHV-135 -> broad-spectrum class A beta-lactamase SHV-135
    blaSHV-137 WP_063864624.1
        product_name:    class A broad-spectrum beta-lactamase SHV-137 -> broad-spectrum class A beta-lactamase SHV-137
    blaSHV-14 WP_063864625.1
        product_name:    class A broad-spectrum beta-lactamase SHV-14 -> broad-spectrum class A beta-lactamase SHV-14
    blaSHV-141 WP_063864626.1
        product_name:    class A broad-spectrum beta-lactamase SHV-141 -> broad-spectrum class A beta-lactamase SHV-141
    blaSHV-142 WP_063864627.1
        product_name:    class A broad-spectrum beta-lactamase SHV-142 -> broad-spectrum class A beta-lactamase SHV-142
    blaSHV-145 WP_063864630.1
        product_name:    class A broad-spectrum beta-lactamase SHV-145 -> broad-spectrum class A beta-lactamase SHV-145
    blaSHV-147 WP_063864632.1
        product_name:    class A broad-spectrum beta-lactamase SHV-147 -> broad-spectrum class A beta-lactamase SHV-147
    blaSHV-148 WP_063864633.1
        product_name:    class A broad-spectrum beta-lactamase SHV-148 -> broad-spectrum class A beta-lactamase SHV-148
    blaSHV-149 WP_063864634.1
        product_name:    class A broad-spectrum beta-lactamase SHV-149 -> broad-spectrum class A beta-lactamase SHV-149
    blaSHV-15 WP_063864635.1
        product_name:    class A extended-spectrum beta-lactamase SHV-15 -> extended-spectrum class A beta-lactamase SHV-15
    blaSHV-150 WP_063864636.1
        product_name:    class A broad-spectrum beta-lactamase SHV-150 -> broad-spectrum class A beta-lactamase SHV-150
    blaSHV-151 WP_063864637.1
        product_name:    class A broad-spectrum beta-lactamase SHV-151 -> broad-spectrum class A beta-lactamase SHV-151
    blaSHV-152 WP_063864638.1
        product_name:    class A extended-spectrum beta-lactamase SHV-152 -> extended-spectrum class A beta-lactamase SHV-152
        pubmed_reference: 23587957 -> 23587957,32284385
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-153 WP_063864639.1
        product_name:    class A extended-spectrum beta-lactamase SHV-153 -> extended-spectrum class A beta-lactamase SHV-153
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-154 WP_063864640.1
        product_name:    class A extended-spectrum beta-lactamase SHV-154 -> extended-spectrum class A beta-lactamase SHV-154
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-16 WP_063864646.1
        product_name:    class A extended-spectrum beta-lactamase SHV-16 -> extended-spectrum class A beta-lactamase SHV-16
    blaSHV-160 WP_063864647.1
        product_name:    class A extended-spectrum beta-lactamase SHV-160 -> extended-spectrum class A beta-lactamase SHV-160
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-161 WP_063864648.1
        product_name:    class A broad-spectrum beta-lactamase SHV-161 -> broad-spectrum class A beta-lactamase SHV-161
    blaSHV-162 WP_063864649.1
        product_name:    class A extended-spectrum beta-lactamase SHV-162 -> extended-spectrum class A beta-lactamase SHV-162
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-163 WP_063864650.1
        product_name:    class A extended-spectrum beta-lactamase SHV-163 -> extended-spectrum class A beta-lactamase SHV-163
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-164 WP_063864651.1
        product_name:    class A broad-spectrum beta-lactamase SHV-164 -> broad-spectrum class A beta-lactamase SHV-164
    blaSHV-165 WP_063864652.1
        product_name:    class A extended-spectrum beta-lactamase SHV-165 -> extended-spectrum class A beta-lactamase SHV-165
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-171 WP_070984444.1
        product_name:    class A broad-spectrum beta-lactamase SHV-171 -> broad-spectrum class A beta-lactamase SHV-171
    blaSHV-179 WP_063864657.1
        product_name:    class A broad-spectrum beta-lactamase SHV-179 -> broad-spectrum class A beta-lactamase SHV-179
    blaSHV-18 WP_063864658.1
        product_name:    class A extended-spectrum beta-lactamase SHV-18 -> extended-spectrum class A beta-lactamase SHV-18
    blaSHV-183 WP_063864661.1
        product_name:    class A extended-spectrum beta-lactamase SHV-183 -> extended-spectrum class A beta-lactamase SHV-183
    blaSHV-185 WP_063864662.1
        product_name:    class A broad-spectrum beta-lactamase SHV-185 -> broad-spectrum class A beta-lactamase SHV-185
    blaSHV-187 WP_021440083.1
        product_name:    class A broad-spectrum beta-lactamase SHV-187 -> extended-spectrum class A beta-lactamase SHV-187
        pubmed_reference: <empty> -> 34248878
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-189 WP_063864665.1
        product_name:    class A broad-spectrum beta-lactamase SHV-189 -> broad-spectrum class A beta-lactamase SHV-189
    blaSHV-2 WP_012477587.1
        product_name:    class A extended-spectrum beta-lactamase SHV-2 -> extended-spectrum class A beta-lactamase SHV-2
    blaSHV-229 WP_223146982.1
        product_name:    class A broad-spectrum beta-lactamase SHV-229 -> broad-spectrum class A beta-lactamase SHV-229
    blaSHV-24 WP_063864670.1
        product_name:    class A extended-spectrum beta-lactamase SHV-24 -> extended-spectrum class A beta-lactamase SHV-24
    blaSHV-25 WP_063864671.1
        product_name:    class A broad-spectrum beta-lactamase SHV-25 -> broad-spectrum class A beta-lactamase SHV-25
    blaSHV-26 WP_023280043.1
        product_name:    inhibitor-resistant class A broad-spectrum beta-lactamase SHV-26 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-26
    blaSHV-27 WP_023282555.1
        product_name:    class A broad-spectrum beta-lactamase SHV-27 -> broad-spectrum class A beta-lactamase SHV-27
    blaSHV-28 WP_004179754.1
        product_name:    class A broad-spectrum beta-lactamase SHV-28 -> broad-spectrum class A beta-lactamase SHV-28
    blaSHV-29 WP_063864672.1
        product_name:    class extended-spectrum A beta-lactamase SHV-29 -> extended-spectrum class A beta-lactamase SHV-29
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-2A WP_032488413.1
        product_name:    class A extended-spectrum beta-lactamase SHV-2a -> extended-spectrum class A beta-lactamase SHV-2a
    blaSHV-3 WP_063864673.1
        product_name:    class A extended-spectrum beta-lactamase SHV-3 -> extended-spectrum class A beta-lactamase SHV-3
    blaSHV-30 WP_032491180.1
        product_name:    class A extended-spectrum beta-lactamase SHV-30 -> extended-spectrum class A beta-lactamase SHV-30
    blaSHV-31 WP_063864674.1
        product_name:    class A extended-spectrum beta-lactamase SHV-31 -> extended-spectrum class A beta-lactamase SHV-31
    blaSHV-32 WP_063864675.1
        product_name:    class A broad-spectrum beta-lactamase SHV-32 -> broad-spectrum class A beta-lactamase SHV-32
    blaSHV-33 WP_023325206.1
        product_name:    class A broad-spectrum beta-lactamase SHV-33 -> broad-spectrum class A beta-lactamase SHV-33
    blaSHV-34 WP_063864676.1
        product_name:    class A extended-spectrum beta-lactamase SHV-34 -> extended-spectrum class A beta-lactamase SHV-34
    blaSHV-36 WP_063864678.1
        product_name:    class A broad-spectrum beta-lactamase SHV-36 -> broad-spectrum class A beta-lactamase SHV-36
    blaSHV-38 WP_063864680.1
        product_name:    class A extended-spectrum beta-lactamase SHV-38 -> extended-spectrum class A beta-lactamase SHV-38
    blaSHV-4 WP_152330890.1
        product_name:    class A extended-spectrum beta-lactamase SHV-4 -> extended-spectrum class A beta-lactamase SHV-4
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-40 WP_063864681.1
        product_name:    class A broad-spectrum beta-lactamase SHV-40 -> broad-spectrum class A beta-lactamase SHV-40
    blaSHV-41 WP_063864682.1
        product_name:    class A broad-spectrum beta-lactamase SHV-41 -> broad-spectrum class A beta-lactamase SHV-41
    blaSHV-42 WP_063864683.1
        product_name:    class A broad-spectrum beta-lactamase SHV-42 -> broad-spectrum class A beta-lactamase SHV-42
    blaSHV-43 WP_032490193.1
        product_name:    class A broad-spectrum beta-lactamase SHV-43 -> broad-spectrum class A beta-lactamase SHV-43
    blaSHV-44 WP_063864684.1
        product_name:    class A broad-spectrum beta-lactamase SHV-44 -> broad-spectrum class A beta-lactamase SHV-44
    blaSHV-45 WP_063864685.1
        product_name:    class A extended-spectrum beta-lactamase SHV-45 -> extended-spectrum class A beta-lactamase SHV-45
        pubmed_reference: <empty> -> 26322883
    blaSHV-46 WP_063864686.1
        product_name:    class A extended-spectrum beta-lactamase SHV-46 -> extended-spectrum class A beta-lactamase SHV-46
    blaSHV-48 WP_063864687.1
        product_name:    class A broad-spectrum beta-lactamase SHV-48 -> broad-spectrum class A beta-lactamase SHV-48
    blaSHV-49 WP_063864688.1
        product_name:    inhibitor-resistant class A broad-spectrum beta-lactamase SHV-49 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-49
    blaSHV-5 WP_011117369.1
        product_name:    class A extended-spectrum beta-lactamase SHV-5 -> extended-spectrum class A beta-lactamase SHV-5
    blaSHV-50 WP_063864689.1
        product_name:    class A broad-spectrum beta-lactamase SHV-50 -> broad-spectrum class A beta-lactamase SHV-50
    blaSHV-51 WP_063864690.1
        product_name:    class A broad-spectrum beta-lactamase SHV-51 -> broad-spectrum class A beta-lactamase SHV-51
    blaSHV-52 WP_063864691.1
        product_name:    inhibitor-resistant class A broad-spectrum beta-lactamase SHV-52 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-52
    blaSHV-55 WP_063864692.1
        product_name:    class A extended-spectrum beta-lactamase SHV-55 -> extended-spectrum class A beta-lactamase SHV-55
    blaSHV-56 WP_063864693.1
        product_name:    inhibitor-resistant class A broad-spectrum beta-lactamase SHV-56 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-56
    blaSHV-57 WP_032490632.1
        product_name:    class A extended-spectrum beta-lactamase SHV-57 -> extended-spectrum class A beta-lactamase SHV-57
    blaSHV-59 WP_063864694.1
        product_name:    class A broad-spectrum beta-lactamase SHV-59 -> broad-spectrum class A beta-lactamase SHV-59
        pubmed_reference: <empty> -> 33507142
    blaSHV-60 WP_004183952.1
        product_name:    class A broad-spectrum beta-lactamase SHV-60 -> broad-spectrum class A beta-lactamase SHV-60
    blaSHV-61 WP_063864695.1
        product_name:    class A broad-spectrum beta-lactamase SHV-61 -> broad-spectrum class A beta-lactamase SHV-61
    blaSHV-62 WP_063864696.1
        product_name:    class A broad-spectrum beta-lactamase SHV-62 -> broad-spectrum class A beta-lactamase SHV-62
    blaSHV-63 WP_063864697.1
        product_name:    class A broad-spectrum beta-lactamase SHV-63 -> broad-spectrum class A beta-lactamase SHV-63
    blaSHV-64 WP_063864698.1
        product_name:    class A extended-spectrum beta-lactamase SHV-64 -> extended-spectrum class A beta-lactamase SHV-64
    blaSHV-65 WP_063864699.1
        product_name:    class A extended-spectrum beta-lactamase SHV-65 -> extended-spectrum class A beta-lactamase SHV-65
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-66 WP_063864700.1
        product_name:    class A extended-spectrum beta-lactamase SHV-66 -> extended-spectrum class A beta-lactamase SHV-66
    blaSHV-7 WP_020316986.1
        product_name:    class A extended-spectrum beta-lactamase SHV-7 -> extended-spectrum class A beta-lactamase SHV-7
    blaSHV-70 WP_032491403.1
        product_name:    class A extended-spectrum beta-lactamase SHV-70 -> extended-spectrum class A beta-lactamase SHV-70
    blaSHV-71 WP_063864703.1
        product_name:    class A broad-spectrum beta-lactamase SHV-71 -> broad-spectrum class A beta-lactamase SHV-71
    blaSHV-72 WP_063864704.1
        product_name:    inhibitor-resistant class A broad-spectrum beta-lactamase SHV-72 -> inhibitor-resistant broad-spectrum class A beta-lactamase SHV-72
    blaSHV-73 WP_063864705.1
        product_name:    class A broad-spectrum beta-lactamase SHV-73 -> broad-spectrum class A beta-lactamase SHV-73
    blaSHV-74 WP_063864706.1
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        pubmed_reference: <empty> -> 20138476
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        pubmed_reference: <empty> -> 27672380
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        product_name:    class A extended-spectrum beta-lactamase TEM-177 -> extended-spectrum class A beta-lactamase TEM-177
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        pubmed_reference: <empty> -> 29941651
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        product_name:    class A extended-spectrum beta-lactamase TEM-19 -> extended-spectrum class A beta-lactamase TEM-19
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        product_name:    class A extended-spectrum beta-lactamase TEM-20 -> extended-spectrum class A beta-lactamase TEM-20
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        product_name:    class A extended-spectrum beta-lactamase TEM-21 -> extended-spectrum class A beta-lactamase TEM-21
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        product_name:    class A extended-spectrum beta-lactamase TEM-211 -> extended-spectrum class A beta-lactamase TEM-211
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        product_name:    class A extended-spectrum beta-lactamase TEM-22 -> extended-spectrum class A beta-lactamase TEM-22
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        product_name:    class A extended-spectrum beta-lactamase TEM-26 -> extended-spectrum class A beta-lactamase TEM-26
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        product_name:    class A extended-spectrum beta-lactamase TEM-28 -> extended-spectrum class A beta-lactamase TEM-28
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        product_name:    class A broad-spectrum beta-lactamase TEM-90 -> broad-spectrum class A beta-lactamase TEM-90
    blaTEM-91 WP_063865088.1
        product_name:    class A extended-spectrum beta-lactamase TEM-91 -> extended-spectrum class A beta-lactamase TEM-91
    blaTEM-92 WP_063865103.1
        product_name:    class A extended-spectrum beta-lactamase TEM-92 -> extended-spectrum class A beta-lactamase TEM-92
    blaTEM-93 WP_032490317.1
        product_name:    class A extended-spectrum beta-lactamase TEM-93 -> extended-spectrum class A beta-lactamase TEM-93
    blaTEM-94 WP_032490318.1
        product_name:    class A extended-spectrum beta-lactamase TEM-94 -> extended-spectrum class A beta-lactamase TEM-94
    blaTEM-95 WP_061659705.1
        product_name:    class A broad-spectrum beta-lactamase TEM-95 -> broad-spectrum class A beta-lactamase TEM-95
    blaTLA-1 WP_032494759.1
        product_name:    class A extended-spectrum beta-lactamase TLA-1 -> extended-spectrum class A beta-lactamase TLA-1
    blaTLA-2 WP_011222052.1
        product_name:    class A extended-spectrum beta-lactamase TLA-2 -> extended-spectrum class A beta-lactamase TLA-2
    blaTLA-3 WP_059512353.1
        product_name:    class A extended-spectrum beta-lactamase TLA-3 -> extended-spectrum class A beta-lactamase TLA-3
    blaVEB-1 WP_000706731.1
        product_name:    class A extended-spectrum beta-lactamase VEB-1 -> extended-spectrum class A beta-lactamase VEB-1
    blaVEB-10 WP_063865150.1
        product_name:    class A extended-spectrum beta-lactamase VEB-10 -> extended-spectrum class A beta-lactamase VEB-10
    blaVEB-11 WP_063865151.1
        product_name:    class A extended-spectrum beta-lactamase VEB-11 -> extended-spectrum class A beta-lactamase VEB-11
    blaVEB-12 WP_063865152.1
        product_name:    class A extended-spectrum beta-lactamase VEB-12 -> extended-spectrum class A beta-lactamase VEB-12
    blaVEB-13 WP_063865153.1
        product_name:    class A extended-spectrum beta-lactamase VEB-13 -> extended-spectrum class A beta-lactamase VEB-13
    blaVEB-14 WP_063865154.1
        product_name:    class A extended-spectrum beta-lactamase VEB-14 -> inhibitor-resistant extended-spectrum class A beta-lactamase VEB-14
        pubmed_reference: <empty> -> 26926646,31992391
    blaVEB-15 WP_063865155.1
        product_name:    class A extended-spectrum beta-lactamase VEB-15 -> extended-spectrum class A beta-lactamase VEB-15
    blaVEB-16 WP_063865156.1
        product_name:    class A extended-spectrum beta-lactamase VEB-16 -> extended-spectrum class A beta-lactamase VEB-16
    blaVEB-17 WP_063865157.1
        product_name:    class A extended-spectrum beta-lactamase VEB-17 -> extended-spectrum class A beta-lactamase VEB-17
    blaVEB-18 WP_065825678.1
        product_name:    class A extended-spectrum beta-lactamase VEB-18 -> extended-spectrum class A beta-lactamase VEB-18
    blaVEB-19 WP_094009812.1
        product_name:    class A extended-spectrum beta-lactamase VEB-19 -> extended-spectrum class A beta-lactamase VEB-19
    blaVEB-2 WP_063865158.1
        product_name:    class A extended-spectrum beta-lactamase VEB-2 -> extended-spectrum class A beta-lactamase VEB-2
    blaVEB-20 WP_128268286.1
        product_name:    class A extended-spectrum beta-lactamase VEB-20 -> inhibitor-resistant extended-spectrum class A beta-lactamase VEB-20
        pubmed_reference: <empty> -> 31992391
    blaVEB-21 WP_044103626.1
        product_name:    class A extended-spectrum beta-lactamase VEB-21 -> extended-spectrum class A beta-lactamase VEB-21
    blaVEB-22 WP_148044475.1
        product_name:    class A extended-spectrum beta-lactamase VEB-22 -> extended-spectrum class A beta-lactamase VEB-22
    blaVEB-23 WP_156404662.1
        product_name:    class A extended-spectrum beta-lactamase VEB-23 -> extended-spectrum class A beta-lactamase VEB-23
    blaVEB-24 WP_156404663.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase VEB-24 -> inhibitor-resistant extended-spectrum class A beta-lactamase VEB-24
    blaVEB-25 WP_160164840.1
        product_name:    class A extended-spectrum beta-lactamase VEB-25 -> inhibitor-resistant extended-spectrum class A beta-lactamase VEB-25
        pubmed_reference: <empty> -> 31992391
    blaVEB-26 WP_179284393.1
        product_name:    class A extended-spectrum beta-lactamase VEB-26 -> extended-spectrum class A beta-lactamase VEB-26
    blaVEB-27 WP_188331880.1
        product_name:    inhibitor-resistant class A extended-spectrum beta-lactamase VEB-27 -> inhibitor-resistant extended-spectrum class A beta-lactamase VEB-27
    blaVEB-28 WP_231869593.1
        product_name:    class A extended-spectrum beta-lactamase VEB-28 -> extended-spectrum class A beta-lactamase VEB-28
    blaVEB-29 WP_219860717.1
        product_name:    class A extended-spectrum beta-lactamase VEB-29 -> extended-spectrum class A beta-lactamase VEB-29
    blaVEB-3 WP_020956917.1
        product_name:    class A extended-spectrum beta-lactamase VEB-3 -> extended-spectrum class A beta-lactamase VEB-3
    blaVEB-30 WP_219860719.1
        product_name:    class A extended-spectrum beta-lactamase VEB-30 -> extended-spectrum class A beta-lactamase VEB-30
    blaVEB-4 WP_063865159.1
        product_name:    class A extended-spectrum beta-lactamase VEB-4 -> extended-spectrum class A beta-lactamase VEB-4
    blaVEB-5 WP_063865160.1
        product_name:    class A extended-spectrum beta-lactamase VEB-5 -> extended-spectrum class A beta-lactamase VEB-5
    blaVEB-6 WP_063865161.1
        product_name:    class A extended-spectrum beta-lactamase VEB-6 -> extended-spectrum class A beta-lactamase VEB-6
    blaVEB-7 WP_063865162.1
        product_name:    class A extended-spectrum beta-lactamase VEB-7 -> extended-spectrum class A beta-lactamase VEB-7
    blaVEB-8 WP_063865163.1
        product_name:    class A extended-spectrum beta-lactamase VEB-8 -> extended-spectrum class A beta-lactamase VEB-8
    blaVEB-9 WP_032494864.1
        product_name:    class A extended-spectrum beta-lactamase VEB-9 -> extended-spectrum class A beta-lactamase VEB-9
    cepA-29 WP_063865204.1
        product_name:    class A extended-spectrum beta-lactamase CepA-29 -> extended-spectrum class A beta-lactamase CepA-29
    cepA-44 WP_032579291.1
        product_name:    class A extended-spectrum beta-lactamase CepA-44 -> extended-spectrum class A beta-lactamase CepA-44
    cepA-49 WP_008659027.1
        product_name:    class A extended-spectrum beta-lactamase CepA-49 -> extended-spectrum class A beta-lactamase CepA-49
    poxtA2 WP_209691075.1
        class:           MACROLIDE -> PHENICOL/OXAZOLIDINONE
        subclass:        MACROLIDE -> CHLORAMPHENICOL/FLORFENICOL/LINEZOLID

Hierarchy nodes added
    core AMR AMR
        blaGMA           blaGMA NF040812.1              GMA family class A beta-lactamase
        blaPJM           blaPJM NF040874.1              PJM family subclass B3 metallo-beta-lactamase
        blaWUS           blaWUS                         WUS family subclass B1 metallo-beta-lactamase
        erm(50)          erm(50)                        23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50)
        erm(51)          erm(51)                        23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(51)
        erm(52)          erm(52)                        23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(52)
        fexB             fexB NF040856.1                chloramphenicol/florfenicol efflux MFS transporter FexB
Changed Hierarchy Nodes
    blaBEL           BEL family extended-spectrum class A beta-lactamase
        name:            BEL family class A extended-spectrum beta-lactamase -> BEL family extended-spectrum class A beta-lactamase
    blaCGA           CGA family extended-spectrum class A beta-lactamase
        name:            CGA family class A extended-spectrum beta-lactamase -> CGA family extended-spectrum class A beta-lactamase
    blaCIA           CIA family extended-spectrum class A beta-lactamase
        name:            CIA family class A extended-spectrum beta-lactamase -> CIA family extended-spectrum class A beta-lactamase
    blaCME           CME family extended-spectrum class A beta-lactamase
        name:            CME family class A extended-spectrum beta-lactamase -> CME family extended-spectrum class A beta-lactamase
    blaCTX-M         CTX-M family extended-spectrum class A beta-lactamase
        name:            CTX-M family class A extended-spectrum beta-lactamase -> CTX-M family extended-spectrum class A beta-lactamase
    blaKLUC          KLUC family extended-spectrum class A beta-lactamase
        name:            KLUC family class A extended-spectrum beta-lactamase -> KLUC family extended-spectrum class A beta-lactamase
    blaOCH           OCH family extended-spectrum class C beta-lactamase
        name:            OCH family class C extended-spectrum beta-lactamase -> OCH family extended-spectrum class C beta-lactamase
    blaOKP           OKP family broad-spectrum class A beta-lactamase
        name:            OKP family class A broad-spectrum beta-lactamase -> OKP family broad-spectrum class A beta-lactamase
    blaOKP-A         OKP-A family broad-spectrum class A beta-lactamase
        name:            OKP-A family class A broad-spectrum beta-lactamase -> OKP-A family broad-spectrum class A beta-lactamase
    blaOKP-B         OKP-B family broad-spectrum class A beta-lactamase
        name:            OKP-B family class A broad-spectrum beta-lactamase -> OKP-B family broad-spectrum class A beta-lactamase
    blaOKP-C         OKP-C family broad-spectrum class A beta-lactamase
        name:            OKP-C family class A broad-spectrum beta-lactamase -> OKP-C family broad-spectrum class A beta-lactamase
    blaOKP-D         OKP-D family broad-spectrum class A beta-lactamase
        name:            OKP-D family class A broad-spectrum beta-lactamase -> OKP-D family broad-spectrum class A beta-lactamase
    blaOXA-24_fam    OXA-24 family carbapenem-hydrolyzing class D beta-lactamase
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-274_fam   OXA-274 family carbapenem-hydrolyzing class D beta-lactamase
        name:            OXA-274 family class D beta-lactamase -> OXA-274 family carbapenem-hydrolyzing class D beta-lactamase
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-286_fam   OXA-286 family carbapenem-hydrolyzing class D beta-lactamase
        name:            OXA-286 family class D beta-lactamase -> OXA-286 family carbapenem-hydrolyzing class D beta-lactamase
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-372_fam   OXA-372 family carbapenem-hydrolyzing class D beta-lactamase
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXY           OXY family extended-spectrum class A beta-lactamase
        name:            OXY family class A extended-spectrum beta-lactamase -> OXY family extended-spectrum class A beta-lactamase
    blaOXY-1         OXY-1 family extended-spectrum class A beta-lactamase
        name:            OXY-1 family class A extended-spectrum beta-lactamase -> OXY-1 family extended-spectrum class A beta-lactamase
    blaOXY-2         OXY-2 family extended-spectrum class A beta-lactamase
        name:            OXY-2 family class A extended-spectrum beta-lactamase -> OXY-2 family extended-spectrum class A beta-lactamase
    blaOXY-3         OXY-3 family extended-spectrum class A beta-lactamase
        name:            OXY-3 family class A extended-spectrum beta-lactamase -> OXY-3 family extended-spectrum class A beta-lactamase
    blaOXY-4         OXY-4 family extended-spectrum class A beta-lactamase
        name:            OXY-4 family class A extended-spectrum beta-lactamase -> OXY-4 family extended-spectrum class A beta-lactamase
    blaOXY-5         OXY-5 family extended-spectrum class A beta-lactamase
        name:            OXY-5 family class A extended-spectrum beta-lactamase -> OXY-5 family extended-spectrum class A beta-lactamase
    blaOXY-6         OXY-6 family extended-spectrum class A beta-lactamase
        name:            OXY-6 family class A extended-spectrum beta-lactamase -> OXY-6 family extended-spectrum class A beta-lactamase
    blaPER           PER family extended-spectrum class A beta-lactamase
        name:            PER family class A extended-spectrum beta-lactamase -> PER family extended-spectrum class A beta-lactamase
    blaPME           PME family extended-spectrum class A beta-lactamase
        name:            PME family class A beta-lactamase -> PME family extended-spectrum class A beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaRASA          RASA family extended-spectrum class A beta-lactamase
        name:            RASA family class A extended-spectrum beta-lactamase -> RASA family extended-spectrum class A beta-lactamase
    blaRUB           RUB family broad-spectrum class A beta-lactamase
        name:            RUB family class A broad-spectrum beta-lactamase -> RUB family broad-spectrum class A beta-lactamase
    blaTLA           TLA family extended-spectrum class A beta-lactamase
        name:            TLA family class A extended-spectrum beta-lactamase -> TLA family extended-spectrum class A beta-lactamase
    blaTLA2          TLA2 family extended-spectrum class A beta-lactamase
        name:            TLA2 family class A extended-spectrum beta-lactamase -> TLA2 family extended-spectrum class A beta-lactamase
    blaVEB           VEB family extended-spectrum class A beta-lactamase
        name:            VEB family class A extended-spectrum beta-lactamase -> VEB family extended-spectrum class A beta-lactamase
    cepA             CepA family extended-spectrum class A beta-lactamase
        name:            CepA family class A extended-spectrum beta-lactamase -> CepA family extended-spectrum class A beta-lactamase
    cfxA             broad-spectrum class A beta-lactamase CfxA
        name:            class A broad-spectrum beta-lactamase CfxA -> broad-spectrum class A beta-lactamase CfxA
    cfxA2            extended-spectrum class A beta-lactamase CfxA2
        name:            class A extended-spectrum beta-lactamase CfxA2 -> extended-spectrum class A beta-lactamase CfxA2
    cfxA3            extended-spectrum class A beta-lactamase CfxA3
        name:            class A extended-spectrum beta-lactamase CfxA3 -> extended-spectrum class A beta-lactamase CfxA3
    cfxA4            extended-spectrum class A beta-lactamase CfxA4
        name:            class A extended-spectrum beta-lactamase CfxA4 -> extended-spectrum class A beta-lactamase CfxA4
    cfxA5            broad-spectrum class A beta-lactamase CfxA5
        name:            class A broad-spectrum beta-lactamase CfxA5 -> broad-spectrum class A beta-lactamase CfxA5
    cfxA6            broad-spectrum class A beta-lactamase CfxA6
        name:            class A broad-spectrum beta-lactamase CfxA6 -> broad-spectrum class A beta-lactamase CfxA6
    cfxA_fam         CfxA family broad-spectrum class A beta-lactamase
        name:            CfxA family class A broad-spectrum beta-lactamase -> CfxA family broad-spectrum class A beta-lactamase
    entFM            enterotoxin EntFM
        hmm_acc:         <empty> -> NF040678.1
    penI_Bp          PenI family extended-spectrum class A beta-lactamase
        name:            PenI family class A extended-spectrum beta-lactamase -> PenI family extended-spectrum class A beta-lactamase
    poxtA            ABC-F type ribosomal protection protein PoxtA
        class:           MACROLIDE -> PHENICOL/OXAZOLIDINONE
        subclass:        MACROLIDE -> CHLORAMPHENICOL/FLORFENICOL/LINEZOLID


----------------------------------------------------------------------
Changes included in 2022-04-04.1
----------------------------------------------------------------------

Overview:

    - The usual addition of new alleles submitted to NCBI and genes/sequences
      identified by curators.
    - New point mutations for Klebsiella, Salmonella, Escherichia, and
      Enterococcus_faecium.
    - Added virulence genes for the Bacillus cereus group.
    - A few new beta-lactamase families (blaBOR, blaGMA, blaHBL).
    - The format of the ReferenceGeneCatalog.txt file has changed to add RefSeq
      coordinates and rename existing fields to make the column headers more
      consistent. This is in preparation for the development of a convenient
      system to download sequences from the Reference Gene Catalog
      (https://www.ncbi.nlm.nih.gov/pathogens/refgene.
        - Changed field names:
            - genbank_cds_start => genbank_start
            - genbank_cds_stop => genbank_stop
            - genbank_strand_orientation => genbank_strand
        - New fields
            - refseq_start
            - refseq_stop
            - refseq_strand
    - Where possible we added RefSeq / GenBank accessions and coordinates to
      point mutation records that were previously missing one or the other.

Note that a new point mutation in Escherichia reveals bug in versions 3.10.23
and earlier. This bug means that with this new database AMRFinderPlus versions
prior to 3.10.24 will no longer detect Escherichia pmrB_L10 mutations. See the
release notes for more information:
https://github.com/ncbi/amr/releases/tag/amrfinder_v3.10.24

The following list omits listing changes in the new/renamed columns:
genbank_start, genbank_end, genbank_strand, refseq_start, refseq_end, and
refseq_strand because those fields were added to every record in the Reference
Gene Catalog. They may be empty if there is no accession, and they are not used
by AMRFinderPlus.

Summary:
   Total proteins: 7229
        Core proteins: 6144
        Plus proteins: 1084
   AMR proteins: 6189
   STRESS proteins: 235
   VIRULENCE proteins: 805
   Point mutations: 939
   Point mutation references: 161
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Clostridioides_difficile,
       Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella,
       Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus,
       Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae,
       Streptococcus_pyogenes
   HMMs: 665

Updates since release 2021-12-21.1:
   Proteins added: 194
       Core proteins added: 130
       Plus proteins added: 64
   AMR proteins added: 130
   VIRULENCE proteins added: 64
   Alleles added: 129
   Point mutations added: 21
   Proteins removed: 1
       Core proteins removed: 1
       Plus proteins removed: 0
   Reference Gene Catalog entries changed: 841
   Hierarchy nodes added: 54
   Hierarchy nodes changed: 5

Added proteins
    core AMR AMR
        fosY             NG_079881.1 WP_072419811.1     fosfomycin resistance bacillithiol transferase FosY
        blaACT-100       NG_079207.1 WP_240067712.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-100
        blaACT-101       NG_079208.1 WP_087529968.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-101
        blaACT-102       NG_079209.1 WP_058690324.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-102
        blaACT-103       NG_079210.1 WP_063943829.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-103
        blaACT-104       NG_079211.1 WP_213782881.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-104
        blaACT-105       NG_079882.1 WP_242934065.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-105
        blaACT-106       NG_079883.1 WP_129256276.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-106
        blaACT-107       NG_079884.1 WP_242934066.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-107
        blaACT-95        NG_079212.1 WP_063434356.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-95
        blaACT-96        NG_079213.1 WP_240067713.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-96
        blaACT-97        NG_079214.1 WP_240067714.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-97
        blaACT-98        NG_079215.1 WP_232932000.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-98
        blaACT-99        NG_079216.1 WP_196347324.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-99
        blaADC-257       NG_079217.1 WP_116020564.1     class C beta-lactamase ADC-257
        blaADC-258       NG_079218.1 WP_114259520.1     class C beta-lactamase ADC-258
        blaADC-261       NG_079219.1 WP_240067715.1     class C beta-lactamase ADC-261
        blaADC-262       NG_079220.1 WP_213702342.1     class C beta-lactamase ADC-262
        blaADC-263       NG_079221.1 WP_109433738.1     class C beta-lactamase ADC-263
        blaADC-264       NG_079222.1 WP_240067716.1     class C beta-lactamase ADC-264
        blaADC-265       NG_079885.1 WP_086265799.1     class C beta-lactamase ADC-265
        blaAFM-4         NG_079223.1 WP_240067717.1     subclass B1 metallo-beta-lactamase AFM-4
        blaBOR-1         NG_079224.1 WP_010926363.1     class A beta-lactamase BOR-1
        blaCTX-M-252     NG_079225.1 WP_240067718.1     class A extended-spectrum beta-lactamase CTX-M-252
        blaHBL-1         NG_079886.1 WP_080700357.1     class A beta-lactamase HBL-1
        blaIMI-24        NG_079226.1 WP_240067719.1     carbapenem-hydrolyzing class A beta-lactamase IMI-24
        blaIMP-92        NG_079227.1 WP_240067720.1     subclass B1 metallo-beta-lactamase IMP-92
        blaIMP-93        NG_079228.1 WP_234855925.1     subclass B1 metallo-beta-lactamase IMP-93
        blaIMP-94        NG_079229.1 WP_240067721.1     subclass B1 metallo-beta-lactamase IMP-94
        blaIMP-95        NG_079887.1 WP_242934067.1     subclass B1 metallo-beta-lactamase IMP-95
        blaKPC-112       NG_079230.1 WP_240067722.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-112
        blaKPC-113       NG_079888.1 WP_242934068.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-113
        blaKPC-114       NG_079889.1 WP_242934069.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-114
        blaKPC-115       NG_079890.1 WP_242934070.1     inhibitor-resistant class A beta-lactamase KPC-115
        blaKPC-116       NG_079891.1 WP_242934071.1     carbapenem-hydrolyzing class A beta-lactamase KPC-116
        blaKPC-117       NG_079892.1 WP_242934072.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-117
        blaKPC-118       NG_079893.1 WP_242934073.1     carbapenem-hydrolyzing class A beta-lactamase KPC-118
        blaKPC-119       NG_079894.1 WP_242934074.1     carbapenem-hydrolyzing class A beta-lactamase KPC-119
        blaKPC-120       NG_079895.1 WP_242934075.1     carbapenem-hydrolyzing class A beta-lactamase KPC-120
        blaKPC-121       NG_079896.1 WP_242934076.1     carbapenem-hydrolyzing class A beta-lactamase KPC-121
        blaKPC-122       NG_079897.1 WP_242934077.1     carbapenem-hydrolyzing class A beta-lactamase KPC-122
        blaKPC-123       NG_079898.1 WP_242934078.1     inhibitor-resistant class A extended-spectrum beta-lactamase KPC-123
        blaKPC-83        NG_079231.1 WP_240067723.1     carbapenem-hydrolyzing class A beta-lactamase KPC-83
        blaKPC-89        NG_079232.1 WP_240067724.1     carbapenem-hydrolyzing class A beta-lactamase KPC-89
        blaKPC-92        NG_079233.1 WP_240067725.1     inhibitor-resistant class A extended-spectrum beta-lactamase KPC-92
        blaOXA-1044      NG_079234.1 WP_240067726.1     OXA-211 family carbapenem-hydrolyzing class D beta-lactamase OXA-1044
        blaOXA-1045      NG_079235.1 WP_046811527.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1045
        blaOXA-1046      NG_079236.1 WP_240067727.1     OXA-10 family class D beta-lactamase OXA-1046
        blaOXA-1047      NG_079237.1 WP_213384363.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1047
        blaOXA-1048      NG_079238.1 WP_240067728.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1048
        blaOXA-1049      NG_079239.1 WP_240067729.1     OXA-2 family class D beta-lactamase OXA-1049
        blaOXA-1050      NG_079240.1 WP_240067730.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1050
        blaOXA-1051      NG_079241.1 WP_240067731.1     class D beta-lactamase OXA-1051
        blaOXA-1053      NG_079242.1 WP_240067732.1     OXA-10 family class D beta-lactamase OXA-1053
        blaOXA-1055      NG_079243.1 WP_240067733.1     OXA-48 family class D beta-lactamase OXA-1055
        blaOXA-1056      NG_079244.1 WP_240067734.1     OXA-198 family carbapenem-hydrolyzing class D beta-lactamase OXA-1056
        blaOXA-1057      NG_079245.1 WP_240067735.1     OXA-198 family carbapenem-hydrolyzing class D beta-lactamase OXA-1057
        blaOXA-1058      NG_079900.1 WP_242934079.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1058
        blaOXA-1059      NG_079901.1 WP_242934080.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1059
        blaOXA-1060      NG_079902.1 WP_242934081.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1060
        blaOXA-1061      NG_079903.1 WP_242934082.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1061
        blaOXA-1062      NG_079904.1 WP_242934083.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1062
        blaOXA-1063      NG_079905.1 WP_242934084.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1063
        blaOXA-1064      NG_079906.1 WP_242934085.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1064
        blaOXA-1065      NG_079907.1 WP_242934086.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1065
        blaOXA-1066      NG_079908.1 WP_242934087.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1066
        blaOXA-1067      NG_079909.1 WP_242934088.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1067
        blaOXA-1068      NG_079910.1 WP_242934089.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1068
        blaOXA-1069      NG_079911.1 WP_242934090.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1069
        blaOXA-1070      NG_079912.1 WP_242934091.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1070
        blaOXA-1071      NG_079913.1 WP_242934092.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1071
        blaOXA-1072      NG_079914.1 WP_242934093.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1072
        blaOXA-1073      NG_079915.1 WP_242934094.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1073
        blaOXA-1074      NG_079916.1 WP_242934095.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1074
        blaOXA-1075      NG_079917.1 WP_242934096.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1075
        blaOXA-1076      NG_079918.1 WP_215763651.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1076
        blaOXA-1077      NG_079919.1 WP_242934097.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1077
        blaOXA-1078      NG_079920.1 WP_242934098.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1078
        blaOXA-1079      NG_079921.1 WP_242934099.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1079
        blaOXA-1080      NG_079922.1 WP_242934100.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1080
        blaOXA-1081      NG_079923.1 WP_242934101.1     OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-1081
        blaOXA-1082      NG_079924.1 WP_242934102.1     OXA-2 family class D beta-lactamase OXA-1082
        blaOXA-1083      NG_079925.1 WP_125064048.1     OXA-2 family class D beta-lactamase OXA-1083
        blaOXA-1084      NG_079926.1 WP_242934103.1     OXA-2 family class D beta-lactamase OXA-1084
        blaOXA-1085      NG_079927.1 WP_242934104.1     OXA-2 family class D beta-lactamase OXA-1085
        blaOXA-1086      NG_079928.1 WP_242934105.1     OXA-10 family class D beta-lactamase OXA-1086
        blaOXA-1089      NG_079246.1 WP_075071939.1     carbapenem-hydrolyzing class D beta-lactamase OXA-1089
        blaOXA-1090      NG_079247.1 WP_051601260.1     carbapenem-hydrolyzing class D beta-lactamase OXA-1090
        blaOXA-1091      NG_079248.1 WP_012045014.1     class D beta-lactamase OXA-1091
        blaOXA-1092      NG_079929.1 WP_242934106.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1092
        blaOXA-1093      NG_079930.1 WP_242934107.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1093
        blaOXA-1094      NG_079931.1 WP_242934108.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1094
        blaOXA-1095      NG_079932.1 WP_242934109.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-1095
        blaOXA-1096      NG_079933.1 WP_242934110.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1096
        blaOXA-1097      NG_079934.1 WP_242934111.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1097
        blaOXA-1098      NG_079935.1 WP_242934112.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1098
        blaOXA-1099      NG_079936.1 WP_014936873.1     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1099
        blaOXA-1100      NG_079937.1 WP_242934113.1     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1100
        blaOXA-1101      NG_079938.1 WP_242934114.1     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1101
        blaOXA-1102      NG_079939.1 WP_242934115.1     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1102
        blaOXA-1103      NG_079940.1 WP_242934116.1     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1103
        blaOXA-1104      NG_079941.1 WP_242934117.1     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1104
        blaOXA-1105      NG_079942.1 WP_242934118.1     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1105
        blaOXA-1106      NG_079943.1 WP_242934119.1     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1106
        blaOXA-1107      NG_079944.1 WP_242934120.1     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase OXA-1107
        blaOXA-198       NG_049494.2 WP_094865115.1     carbapenem-hydrolyzing class D beta-lactamase OXA-198
        blaOXA-289       NG_079946.1 WP_081400730.1     class D beta-lactamase OXA-289
        blaOXA-290       NG_079947.1 WP_081398973.1     class D beta-lactamase OXA-290
        blaPAM-2         NG_079249.1 WP_173179784.1     subclass B3 metallo-beta-lactamase PAM-2
        blaPDC-501       NG_079250.1 WP_240067736.1     class C beta-lactamase PDC-501
        blaPDC-502       NG_079251.1 WP_240067737.1     class C beta-lactamase PDC-502
        blaPDC-503       NG_079252.1 WP_240067738.1     class C beta-lactamase PDC-503
        blaPDC-504       NG_079253.1 WP_240067739.1     class C beta-lactamase PDC-504
        blaPDC-505       NG_079254.1 WP_240067740.1     class C beta-lactamase PDC-505
        blaPDC-506       NG_079255.1 WP_240067741.1     class C beta-lactamase PDC-506
        blaPDC-507       NG_079256.1 WP_240067742.1     class C beta-lactamase PDC-507
        blaPDC-508       NG_079257.1 WP_240067743.1     class C beta-lactamase PDC-508
        blaPDC-509       NG_079258.1 WP_240067744.1     class C beta-lactamase PDC-509
        blaPDC-510       NG_079259.1 WP_240067745.1     class C beta-lactamase PDC-510
        blaPDC-511       NG_079260.1 WP_240067746.1     class C beta-lactamase PDC-511
        blaPDC-512       NG_079948.1 WP_242934121.1     class C beta-lactamase PDC-512
        blaPDC-514       NG_079949.1 WP_242934122.1     class C beta-lactamase PDC-514
        blaPDC-515       NG_079950.1 WP_242934123.1     class C beta-lactamase PDC-515
        blaPDC-516       NG_079951.1 WP_242934124.1     class C beta-lactamase PDC-516
        blaTEM-245       NG_079952.1 WP_242934125.1     class A beta-lactamase TEM-245
        blaTEM-246       NG_079953.1 WP_242934126.1     class A beta-lactamase TEM-246
        blaVIM-80        NG_079261.1 WP_155684882.1     subclass B1 metallo-beta-lactamase VIM-80
        mcr-1.33         NG_079262.1 WP_240067747.1     phosphoethanolamine--lipid A transferase MCR-1.33
        mcr-1.34         NG_079263.1 WP_231236808.1     phosphoethanolamine--lipid A transferase MCR-1.34
        mcr-10.5         NG_079954.1 WP_242934127.1     phosphoethanolamine--lipid A transferase MCR-10.5
    plus VIRULENCE VIRULENCE
        pagA             AF065404.1 AAD32414.1          anthrax toxin protective antigen
        atxA             AF065404.1 AAD32423.1          anthrax toxin expression trans-acting transcriptional regulator AtxA
        plcR             AF132087.1 AAD41788.1          transcriptional regulator PlcR
        capE             AF188935.1 AAF13659.1          capsule biosynthesis protein CapE
        capB             AF188935.1 AAF13663.1          capsule biosynthesis protein CapB
        sodC1            AE006468.2 AAL19978.1          superoxide dismutase [Cu-Zn] SodC1
        lef              AE011190.1 AAM26117.1          anthrax toxin lethal factor
        capD             AE011191.1 AAM26219.1          capsule biosynthesis gamma-glutamyltransferase CapD
        capA             AE011191.1 AAM26220.1          capsular polyglutamate synthetase CapA
        capC             AE011191.1 AAM26221.1          capsular polyglutamate amide ligase/translocase CapC
        hlyIIR           AY212780.1 AAO74585.1          hemolysin II regulator HlyIIR
        inhA2            AE016877.1 AAP07680.1          M6 family metalloprotease immune inhibitor InhA2
        cytK2            AE016877.1 AAP08097.1          beta-channel forming cytolysin CytK2
        nheC             AE016877.1 AAP08785.1          non-hemolytic enterotoxin NHE subunit C
        entFM            AE016877.1 AAP08924.1          enterotoxin EntFM
        hblB             AE016877.1 AAP10046.1          hemolytic enterotoxin HBL binding subunit HblB
        hblD             AE016877.1 AAP10047.1          hemolytic enterotoxin HBL lytic component L1
        hblC             AE016877.1 AAP10048.1          hemolytic enterotoxin HBL lytic component L2
        hlyII            AE016877.1 AAP10457.1          hemolysin II HlyII
        plcA             AE016877.1 AAP10686.1          phosphatidylinositol diacylglycerol-lyase
        inhA2            AE016879.1 AAP24685.1          M6 family metalloprotease immune inhibitor InhA2
        sph              AE016879.1 AAP24691.1          sphingomyelinase C
        alo              AE016879.1 AAP27127.1          anthrolysin O/cereolysin O family cholesterol-dependent cytolysin Alo
        plcA             AE016879.1 AAP27624.1          phosphatidylinositol diacylglycerol-lyase
        cerA             AE017194.1 AAS39677.1          phospholipase CerA
        nheA             AE017194.1 AAS40892.1          non-hemolytic enterotoxin NHE subunit A
        nheB             AE017194.1 AAS40893.1          non-hemolytic enterotoxin NHE subunit B
        nheC             AE017194.1 AAS40894.1          non-hemolytic enterotoxin NHE subunit C
        plcR             AE017355.1 AAT61178.1          transcriptional regulator PlcR
        alo              AY818309.1 AAX88798.1          anthrolysin O/cereolysin O family cholesterol-dependent cytolysin Alo
        plcR             DQ153391.1 AAZ81519.1          transcriptional regulator PlcR
        cesB             DQ360825.1 ABD14712.1          cereulide non-ribosomal peptide synthetase CesB
        cesC             DQ360825.1 ABD14713.1          cereulide export ABC transporter permease ATP-binding protein CesC
        cesD             DQ360825.1 ABD14714.1          cereulide export ABC transporter permease subunit CesD
        cytK1            DQ885233.1 ABI52591.1          beta-channel forming cytolysin CytK1
        entFM            CP000764.1 ABS21809.1          enterotoxin EntFM
        inhA1            CP001903.1 ADH05944.1          M6 family metalloprotease immune inhibitor InhA1
        plcA             CP001907.1 AEA17368.1          phosphatidylinositol diacylglycerol-lyase
        entFM            CP002091.1 AFH83235.1          enterotoxin EntFM
        cerB             KC527544.1 AGL98063.1          sphingomyelinase CerB
        bpsH             CP009940.1 AIY72950.1          oligosaccharide flippase family protein BpsH
        cya              CP009330.1 AJG68144.1          anthrax toxin edema factor
        entFM            CP009692.1 AJH19624.1          enterotoxin EntFM
        bpsX             CP009591.1 AJI07938.1          LytR family transcriptional regulator BpsX
        bpsA             CP009591.1 AJI07978.1          chain length determinant family protein BpsA
        bpsC             CP009591.1 AJI07989.1          UTP--glucose-1-phosphate uridylyltransferase BpsC
        bpsF             CP009591.1 AJI08022.1          UDP-N-acetylglucosamine 2-epimerase BpsF
        bpsE             CP009591.1 AJI08079.1          N-acetylneuraminate synthase family protein BpsE
        bpsG             CP009591.1 AJI08113.1          acylneuraminate cytidylyltransferase family protein BpsG
        hblA             AJ007794.1 CAB64770.1          hemolytic enterotoxin HBL binding subunit HblA
        sph              AJ629412.1 CAF33353.1          sphingomyelinase C
        entFM            ACMA01000037.1 EEK89940.1      enterotoxin EntFM
        entFM            ACML01000111.1 EEL50994.1      enterotoxin EntFM
        entFM            ACMV01000124.1 EEM05837.1      enterotoxin EntFM
        entFM            AHEA01000026.1 EJQ77255.1      enterotoxin EntFM
        entFM            AHDB01000025.1 EJS75599.1      enterotoxin EntFM
        hasA             JTAG01000003.1 KHA45933.1      hyaluronan synthase HasA
        cesA             LRAA01000202.1 KXI80363.1      cereulide non-ribosomal peptide synthetase CesA
        entFM            JAIKLI010000168.1 MBY0597968.1 enterotoxin EntFM
        tccP             MPGY01000110.1 OJF41834.1      Tir-cytoskeleton coupling protein TccP
        plcA             NVMJ01000055.1 PDZ54940.1      phosphatidylinositol diacylglycerol-lyase
        alo              CP053938.1 QKI25716.1          anthrolysin O/cereolysin O family cholesterol-dependent cytolysin Alo
        bpsD             CP065744.1 QPS53461.1          sugar transferase BpsD
        bpsB             CP065744.1 QPS53570.1          tyrosine-protein kinase BpsB
Added point mutations
    core AMR POINT
        basR_A80V        COLISTIN Escherichia
        lapB_V43G        COLISTIN Klebsiella
        lpxM_V30G        COLISTIN Klebsiella
        mgrB_C39STOP     COLISTIN Klebsiella
        mgrB_L17R        COLISTIN Klebsiella
        mgrB_Q30STOP     COLISTIN Klebsiella
        mgrB_V32G        COLISTIN Klebsiella
        pbp5_M485A       BETA-LACTAM Enterococcus_faecium
        pbp5_M485T       BETA-LACTAM Enterococcus_faecium
        phoQ_A20S        COLISTIN Klebsiella
        phoQ_D266DD      COLISTIN Klebsiella
        phoQ_S56R        COLISTIN Klebsiella
        pmrB_ALNQLV129del COLISTIN Klebsiella
        pmrB_E123D       COLISTIN Escherichia
        pmrB_L14Q        COLISTIN Escherichia
        pmrB_P94A        COLISTIN Escherichia
        pmrB_R89P        COLISTIN Salmonella
        pmrB_RPISLR6del  COLISTIN Escherichia
        pmrB_RQRL11del   COLISTIN Salmonella
        pmrB_T92P        COLISTIN Escherichia
        pmrB_Y358N       COLISTIN Escherichia
Removed proteins
    core AMR AMR
        blaOXA-198       NG_049494.1 WP_063861498.1     class D beta-lactamase OXA-198
Changed reference gene catalog records
    50S_L22_A103C WP_002851214.1
        genbank_nucleotide_accession: <empty> -> AL111168.1
        refseq_nucleotide_accession: <empty> -> NC_002163.1
    50S_L22_A103V WP_002779996.1
        genbank_nucleotide_accession: <empty> -> CP011015.1
        refseq_nucleotide_accession: <empty> -> NZ_CP011015.1
    50S_L22_A103V WP_002851214.1
        genbank_nucleotide_accession: <empty> -> AL111168.1
        refseq_nucleotide_accession: <empty> -> NC_002163.1
    50S_L22_A84D WP_002779996.1
        genbank_nucleotide_accession: <empty> -> CP011015.1
        refseq_nucleotide_accession: <empty> -> NZ_CP011015.1
    50S_L22_A84D WP_002851214.1
        genbank_nucleotide_accession: <empty> -> AL111168.1
        refseq_nucleotide_accession: <empty> -> NC_002163.1
    50S_L22_A88E WP_002779996.1
        genbank_nucleotide_accession: <empty> -> CP011015.1
        refseq_nucleotide_accession: <empty> -> NZ_CP011015.1
    50S_L22_A88E WP_002851214.1
        genbank_nucleotide_accession: <empty> -> AL111168.1
        refseq_nucleotide_accession: <empty> -> NC_002163.1
    50S_L22_G86E WP_002779996.1
        genbank_nucleotide_accession: <empty> -> CP011015.1
        refseq_nucleotide_accession: <empty> -> NZ_CP011015.1
    50S_L22_G86E WP_002851214.1
        genbank_nucleotide_accession: <empty> -> AL111168.1
        refseq_nucleotide_accession: <empty> -> NC_002163.1
    50S_L22_G86V WP_002779996.1
        genbank_nucleotide_accession: <empty> -> CP011015.1
        refseq_nucleotide_accession: <empty> -> NZ_CP011015.1
    50S_L22_G86V WP_002851214.1
        genbank_nucleotide_accession: <empty> -> AL111168.1
        refseq_nucleotide_accession: <empty> -> NC_002163.1
    acrB_R620C WP_086259262.1
        genbank_nucleotide_accession: <empty> -> NENT01000005.1
        refseq_nucleotide_accession: <empty> -> NZ_NENT01000005.1
    acrB_R717L WP_001132507.1
        genbank_nucleotide_accession: <empty> -> CP012091.1
        refseq_nucleotide_accession: <empty> -> NZ_CP012091.1
    acrB_R717Q WP_001132507.1
        genbank_nucleotide_accession: <empty> -> CP012091.1
        refseq_nucleotide_accession: <empty> -> NZ_CP012091.1
    acrR_M109I WP_002892080.1
        genbank_nucleotide_accession: <empty> -> CP000647.1
        refseq_nucleotide_accession: <empty> -> NC_009648.1
    acrR_R45C WP_000101737.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    acrR_V165I WP_002892080.1
        genbank_nucleotide_accession: <empty> -> CP000647.1
        refseq_nucleotide_accession: <empty> -> NC_009648.1
    acrR_Y114F WP_002892080.1
        genbank_nucleotide_accession: <empty> -> CP000647.1
        refseq_nucleotide_accession: <empty> -> NC_009648.1
    adeR_A91V WP_031379794.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeR_D20N WP_031379794.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeR_E219A WP_031379794.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeR_L192R WP_031379794.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeR_P116L WP_031379794.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeR_P56S WP_031379794.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeS_G336S WP_031379793.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeS_H189Y WP_031379793.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeS_I252S WP_031379793.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeS_N125K WP_031379793.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeS_Q163STOP WP_031379793.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeS_R152K WP_031379793.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    adeS_T153M WP_031379793.1
        genbank_nucleotide_accession: <empty> -> JNOT01000030.1
        refseq_nucleotide_accession: <empty> -> NZ_JNOT01000030.1
    ampD_H77Y WP_003112844.1
        genbank_nucleotide_accession: <empty> -> AE004091.2
        refseq_nucleotide_accession: <empty> -> NC_002516.2
    ampD_T139M WP_003112844.1
        genbank_nucleotide_accession: <empty> -> AE004091.2
        refseq_nucleotide_accession: <empty> -> NC_002516.2
    ampR_D135G WP_003137572.1
        genbank_nucleotide_accession: <empty> -> CP000438.1
        refseq_nucleotide_accession: <empty> -> NC_008463.1
    ampR_G154R WP_003137572.1
        genbank_nucleotide_accession: <empty> -> CP000438.1
        refseq_nucleotide_accession: <empty> -> NC_008463.1
    arnC_C161Y WP_014906821.1
        genbank_nucleotide_accession: <empty> -> LFAY01000067.1
    basR_G15R WP_094970923.1
        genbank_nucleotide_accession: <empty> -> NQIR01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    basR_G53A WP_094970923.1
        genbank_nucleotide_accession: <empty> -> NQIR01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    basR_G53C WP_094970923.1
        genbank_nucleotide_accession: <empty> -> NQIR01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    basR_G53E WP_094970923.1
        genbank_nucleotide_accession: <empty> -> NQIR01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    basR_G53R WP_094970923.1
        genbank_nucleotide_accession: <empty> -> NQIR01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    basR_G53S WP_094970923.1
        genbank_nucleotide_accession: <empty> -> NQIR01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    basR_G53V WP_094970923.1
        genbank_nucleotide_accession: <empty> -> NQIR01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    basR_G53W WP_094970923.1
        genbank_nucleotide_accession: <empty> -> NQIR01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    basR_L105P WP_094970923.1
        genbank_nucleotide_accession: <empty> -> NQIR01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    basR_R81L WP_094970923.1
        genbank_nucleotide_accession: <empty> -> NQIR01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    basR_R81S WP_094970923.1
        genbank_nucleotide_accession: <empty> -> NQIR01000016.1
        pubmed_reference: <empty> -> 30863849
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    basR_S39I WP_094970923.1
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        pubmed_reference: <empty> -> 30863849
        refseq_nucleotide_accession: <empty> -> NZ_NQIR01000016.1
    blaKPC-46 WP_148044421.1
        pubmed_reference: <empty> -> 35107303
    blaKPC-66 WP_188331871.1
        pubmed_reference: 34339281 -> 34339281, 35107303
    blaKPC-71 WP_194293134.1
        product_name:    inhibitor-resistant class A beta-lactamase KPC-71 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-71
        pubmed_reference: <empty> -> 34935448, 35080422
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaNDM-37 WP_214251060.1
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        genbank_protein_accession: MBT0809506.1 -> ULB43298.1
    blaOXA-1005 WP_163170629.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1016 WP_219860728.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-1036 WP_104442312.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-646 WP_039902635.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-647 WP_140423315.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-648 WP_140423316.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-830 WP_152315468.1
        product_name:    class D beta-lactamase OXA-830 -> class D extended-spectrum beta-lactamase OXA-830
        pubmed_reference: <empty> -> 31849884
    blaOXA-900 WP_178317675.1
        product_name:    class D beta-lactamase OXA-900 -> carbapenem-hydrolyzing class D beta-lactamase OXA-900
        pubmed_reference: <empty> -> 34576793
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-915 WP_168370988.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-991 WP_231869616.1
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaSFDC-1 WP_218519361.1
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    cdsA_D222N WP_000159119.1
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    cls_A20D WP_002289473.1
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        refseq_nucleotide_accession: <empty> -> NZ_CP013009.1
    cls_A23V WP_000571549.1
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    cls_D27N WP_002289473.1
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        refseq_nucleotide_accession: <empty> -> NZ_CP013009.1
    cls_F60S WP_000571549.1
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        refseq_nucleotide_accession: <empty> -> NC_007795.1
    cls_G178T WP_002289473.1
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    cls_H215R WP_002289473.1
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        refseq_nucleotide_accession: <empty> -> NZ_CP013009.1
    cls_H215R WP_002413481.1
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    cls_K59T WP_002289473.1
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    cls_L52F WP_000571549.1
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        refseq_nucleotide_accession: <empty> -> NC_007795.1
    cls_N13I WP_002289473.1
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        refseq_nucleotide_accession: <empty> -> NZ_CP013009.1
    cls_N13T WP_002289473.1
        genbank_nucleotide_accession: <empty> -> CP013009.1
        refseq_nucleotide_accession: <empty> -> NZ_CP013009.1
    cls_NFQ77del WP_002413481.1
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        refseq_nucleotide_accession: <empty> -> NC_017316.1
    cls_R218Q WP_002289473.1
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        refseq_nucleotide_accession: <empty> -> NZ_CP013009.1
    cls_R218Q WP_002413481.1
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        refseq_nucleotide_accession: <empty> -> NC_017316.1
    cls_R267H WP_002289473.1
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        refseq_nucleotide_accession: <empty> -> NZ_CP013009.1
    cls_R267H WP_002413481.1
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    cls_T33N WP_000571549.1
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        refseq_nucleotide_accession: <empty> -> NC_007795.1
    cmeR_G86A WP_002843095.1
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    crrB_F84S WP_004184324.1
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        refseq_nucleotide_accession: <empty> -> NZ_PYBH01000009.1
    crrB_G183V WP_004184324.1
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        pubmed_reference: <empty> -> 28874377
        refseq_nucleotide_accession: <empty> -> NZ_PYBH01000009.1
    crrB_L94M WP_004184324.1
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        pubmed_reference: <empty> -> 25385117
        refseq_nucleotide_accession: <empty> -> NZ_PYBH01000009.1
    crrB_N141I WP_004184324.1
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        pubmed_reference: <empty> -> 27067316
        refseq_nucleotide_accession: <empty> -> NZ_PYBH01000009.1
    crrB_N141Y WP_004184324.1
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        pubmed_reference: <empty> -> 28874377
        refseq_nucleotide_accession: <empty> -> NZ_PYBH01000009.1
    crrB_P151L WP_004184324.1
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        pubmed_reference: <empty> -> 28874377
        refseq_nucleotide_accession: <empty> -> NZ_PYBH01000009.1
    crrB_P151S WP_004184324.1
        genbank_nucleotide_accession: <empty> -> PYBH01000009.1
        pubmed_reference: <empty> -> 27067316
        refseq_nucleotide_accession: <empty> -> NZ_PYBH01000009.1
    crrB_Q10L WP_004184324.1
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        pubmed_reference: <empty> -> 25385117
        refseq_nucleotide_accession: <empty> -> NZ_PYBH01000009.1
    crrB_S195N WP_004184324.1
        genbank_nucleotide_accession: <empty> -> PYBH01000009.1
        pubmed_reference: <empty> -> 27067316
        refseq_nucleotide_accession: <empty> -> NZ_PYBH01000009.1
    crrB_W140R WP_004184324.1
        genbank_nucleotide_accession: <empty> -> PYBH01000009.1
        pubmed_reference: <empty> -> 27067316
        refseq_nucleotide_accession: <empty> -> NZ_PYBH01000009.1
    crrB_Y31H WP_004184324.1
        genbank_nucleotide_accession: <empty> -> PYBH01000009.1
        pubmed_reference: <empty> -> 27067316
        refseq_nucleotide_accession: <empty> -> NZ_PYBH01000009.1
    cyaA_S352T WP_000281668.1
        genbank_nucleotide_accession: <empty> -> HG738867.1
        refseq_nucleotide_accession: <empty> -> NZ_HG738867.1
    dacB_G437D WP_003091272.1
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        refseq_nucleotide_accession: <empty> -> NC_002516.2
    dacB_T428P WP_003091272.1
        genbank_nucleotide_accession: <empty> -> AE004091.2
        refseq_nucleotide_accession: <empty> -> NC_002516.2
    dacB_W459STOP WP_003091272.1
        genbank_nucleotide_accession: <empty> -> AE004091.2
        refseq_nucleotide_accession: <empty> -> NC_002516.2
    dfrB_F99I WP_000175752.1
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        refseq_nucleotide_accession: <empty> -> NZ_CP013132.1
    dfrB_F99S WP_000175752.1
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        refseq_nucleotide_accession: <empty> -> NZ_CP013132.1
    dfrB_F99Y WP_000175752.1
        genbank_nucleotide_accession: <empty> -> CP013132.1
        refseq_nucleotide_accession: <empty> -> NZ_CP013132.1
    dfrB_H150R WP_000175752.1
        genbank_nucleotide_accession: <empty> -> CP013132.1
        refseq_nucleotide_accession: <empty> -> NZ_CP013132.1
    dfrB_H31N WP_000175752.1
        genbank_nucleotide_accession: <empty> -> CP013132.1
        refseq_nucleotide_accession: <empty> -> NZ_CP013132.1
    dfrB_L21V WP_000175752.1
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        refseq_nucleotide_accession: <empty> -> NZ_CP013132.1
    dfrB_L41F WP_000175752.1
        genbank_nucleotide_accession: <empty> -> CP013132.1
        refseq_nucleotide_accession: <empty> -> NZ_CP013132.1
    dfrB_N60I WP_000175752.1
        genbank_nucleotide_accession: <empty> -> CP013132.1
        refseq_nucleotide_accession: <empty> -> NZ_CP013132.1
    eatA_T450I WP_002296175.1
        genbank_nucleotide_accession: <empty> -> CP003351.1
        refseq_nucleotide_accession: <empty> -> NC_017022.1
    emrR_L113P WP_000378442.1
        genbank_nucleotide_accession: <empty> -> AWBL01000027.1
    emrR_L64R WP_000378442.1
        genbank_nucleotide_accession: <empty> -> AWBL01000027.1
    fabG_Y151V WP_001718014.1
        genbank_nucleotide_accession: <empty> -> AQDR01000067.1
        refseq_nucleotide_accession: <empty> -> NZ_AQDR01000067.1
    fabI_F203A WP_000506490.1
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        refseq_nucleotide_accession: <empty> -> NC_000913.3
    fabI_F203C WP_000506490.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    fabI_F203L WP_000506490.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    fabI_F203V WP_000506490.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    fabI_G93A WP_000506490.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    fabI_G93S WP_000506490.1
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        refseq_nucleotide_accession: <empty> -> NC_000913.3
    fabI_G93V WP_000506490.1
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        refseq_nucleotide_accession: <empty> -> NC_000913.3
    fabI_M159T WP_000506490.1
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        refseq_nucleotide_accession: <empty> -> NC_000913.3
    folP_F25I WP_011017740.1
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        refseq_nucleotide_accession: <empty> -> NC_003485.1
    folP_F28I WP_000764731.1
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        refseq_nucleotide_accession: <empty> -> NZ_BGJU01000040.1
    folP_F28L WP_000764731.1
        genbank_nucleotide_accession: <empty> -> BGJU01000040.1
        refseq_nucleotide_accession: <empty> -> NZ_BGJU01000040.1
    folP_P64A WP_000764731.1
        genbank_nucleotide_accession: <empty> -> BGJU01000040.1
        refseq_nucleotide_accession: <empty> -> NZ_BGJU01000040.1
    folP_P64H WP_000764731.1
        genbank_nucleotide_accession: <empty> -> BGJU01000040.1
        refseq_nucleotide_accession: <empty> -> NZ_BGJU01000040.1
    folP_P64L WP_000764731.1
        genbank_nucleotide_accession: <empty> -> BGJU01000040.1
        refseq_nucleotide_accession: <empty> -> NZ_BGJU01000040.1
    folP_P64R WP_000764731.1
        genbank_nucleotide_accession: <empty> -> BGJU01000040.1
        refseq_nucleotide_accession: <empty> -> NZ_BGJU01000040.1
    folP_P64S WP_000764731.1
        genbank_nucleotide_accession: <empty> -> BGJU01000040.1
        refseq_nucleotide_accession: <empty> -> NZ_BGJU01000040.1
    folP_R228S WP_003702942.1
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        refseq_nucleotide_accession: <empty> -> NZ_DS999940.1
    ftsI_A515V WP_000227936.1
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    ftsI_I336IKYRI WP_000642196.1
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    ftsI_I336IPYRI WP_000642196.1
        genbank_nucleotide_accession: <empty> -> K00137.1
    ftsI_N337NYRIN WP_000642196.1
        genbank_nucleotide_accession: <empty> -> K00137.1
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    fusA_A655V WP_000090315.1
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        genbank_nucleotide_accession: <empty> -> CP024168.1
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        genbank_nucleotide_accession: <empty> -> CP010319.1
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    pbp4_E218K WP_123090655.1
        genbank_nucleotide_accession: <empty> -> RIXR01000001.1
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    pbp4_F241R WP_123090655.1
        genbank_nucleotide_accession: <empty> -> RIXR01000001.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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    penA_A501P WP_003693546.1
        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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    penA_G545S WP_003693546.1
        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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        genbank_nucleotide_accession: <empty> -> CP012026.1
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    pgsA_K66R WP_001025093.1
        genbank_nucleotide_accession: <empty> -> BA000033.2
        refseq_nucleotide_accession: <empty> -> NC_003923.1
    pgsA_S177F WP_001025093.1
        genbank_nucleotide_accession: <empty> -> BA000033.2
        refseq_nucleotide_accession: <empty> -> NC_003923.1
    pgsA_V59N WP_001025093.1
        genbank_nucleotide_accession: <empty> -> BA000033.2
        refseq_nucleotide_accession: <empty> -> NC_003923.1
    phoP_A110V WP_003082436.1
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    phoP_D191Y WP_004150807.1
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    phoP_I201N WP_004150807.1
        genbank_nucleotide_accession: <empty> -> MAGH01000012.1
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    phoP_R117L WP_003082436.1
        genbank_nucleotide_accession: <empty> -> AE004091.2
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    phoP_V3F WP_004150807.1
        genbank_nucleotide_accession: <empty> -> MAGH01000012.1
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        refseq_nucleotide_accession: <empty> -> NZ_MAGH01000012.1
    phoQ_A20P WP_004147969.1
        genbank_nucleotide_accession: <empty> -> FWOZ01000025.1
        refseq_nucleotide_accession: <empty> -> NZ_FWOZ01000025.1
    phoQ_D438N WP_004147969.1
        genbank_nucleotide_accession: <empty> -> FWOZ01000025.1
        refseq_nucleotide_accession: <empty> -> NZ_FWOZ01000025.1
    phoQ_G385S WP_004147969.1
        genbank_nucleotide_accession: <empty> -> FWOZ01000025.1
        pubmed_reference: <empty> -> 31513705
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    phoQ_K123Q WP_003082438.1
        genbank_nucleotide_accession: <empty> -> AE004091.2
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    phoQ_L26P WP_004147969.1
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        pubmed_reference: <empty> -> 25691646
        refseq_nucleotide_accession: <empty> -> NZ_FWOZ01000025.1
    phoQ_L348Q WP_004147969.1
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        pubmed_reference: <empty> -> 25264127
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    phoQ_L396Q WP_004147969.1
        genbank_nucleotide_accession: <empty> -> FWOZ01000025.1
        refseq_nucleotide_accession: <empty> -> NZ_FWOZ01000025.1
    phoQ_L96P WP_004147969.1
        genbank_nucleotide_accession: <empty> -> FWOZ01000025.1
        pubmed_reference: <empty> -> 25264127
        refseq_nucleotide_accession: <empty> -> NZ_FWOZ01000025.1
    phoQ_R16C WP_004147969.1
        genbank_nucleotide_accession: <empty> -> FWOZ01000025.1
        refseq_nucleotide_accession: <empty> -> NZ_FWOZ01000025.1
    phoQ_S174N WP_004147969.1
        genbank_nucleotide_accession: <empty> -> FWOZ01000025.1
        pubmed_reference: <empty> -> 23997018
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    phoQ_V260G WP_003082438.1
        genbank_nucleotide_accession: <empty> -> AE004091.2
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    pmrA_G15R WP_000697899.1
        genbank_nucleotide_accession: <empty> -> AAADZC010000031.1
    pmrA_G53C WP_002895659.1
        genbank_nucleotide_accession: <empty> -> JMZQ01000002.1
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        genbank_nucleotide_accession: <empty> -> AAADZC010000031.1
    pmrA_G53R WP_000697899.1
        genbank_nucleotide_accession: <empty> -> AAADZC010000031.1
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        genbank_nucleotide_accession: <empty> -> JMZQ01000002.1
        pubmed_reference: <empty> -> 25264127, 27191712
    pmrA_R81C WP_000697899.1
        genbank_nucleotide_accession: <empty> -> AAADZC010000031.1
    pmrA_R81H WP_000697899.1
        genbank_nucleotide_accession: <empty> -> AAADZC010000031.1
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        genbank_nucleotide_accession: <empty> -> JMZQ01000002.1
        pubmed_reference: <empty> -> 25264127
    pmrB_A159P WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_A159V WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_C84R WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_C84Y WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_E121A WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_E121K WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_E121Q WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_E166K WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_E166K WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_G206D WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
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        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_G206W WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_L10P WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_L10R WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_L14F WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_L14R WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
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        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_L17Q WP_004179093.1
        genbank_nucleotide_accession: <empty> -> UISW01000002.1
        pubmed_reference: <empty> -> 27191712
        refseq_nucleotide_accession: <empty> -> NZ_UISW01000002.1
    pmrB_L22P WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_L82R WP_004179093.1
        genbank_nucleotide_accession: <empty> -> UISW01000002.1
        pubmed_reference: <empty> -> 25022583
        refseq_nucleotide_accession: <empty> -> NZ_UISW01000002.1
    pmrB_M186I WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_N130Y WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_P94L WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
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        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_P94Q WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_P94S WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_R14del WP_004179093.1
        genbank_nucleotide_accession: <empty> -> UISW01000002.1
        refseq_nucleotide_accession: <empty> -> NZ_UISW01000002.1
    pmrB_R155P WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_R256G WP_004179093.1
        genbank_nucleotide_accession: <empty> -> UISW01000002.1
        pubmed_reference: <empty> -> 25691646
        refseq_nucleotide_accession: <empty> -> NZ_UISW01000002.1
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        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
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        genbank_nucleotide_accession: <empty> -> UISW01000002.1
        refseq_nucleotide_accession: <empty> -> NZ_UISW01000002.1
    pmrB_S29R WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_S305R WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_S85R WP_004179093.1
        genbank_nucleotide_accession: <empty> -> UISW01000002.1
        pubmed_reference: <empty> -> 25264127
        refseq_nucleotide_accession: <empty> -> NZ_UISW01000002.1
    pmrB_T140P WP_004179093.1
        genbank_nucleotide_accession: <empty> -> UISW01000002.1
        pubmed_reference: <empty> -> 25264127
        refseq_nucleotide_accession: <empty> -> NZ_UISW01000002.1
    pmrB_T147A WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
    pmrB_T147P WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_T156M WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_T156M WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
        refseq_nucleotide_accession: <empty> -> NZ_JUCJ01000016.1
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        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
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        genbank_nucleotide_accession: <empty> -> UISW01000002.1
        pubmed_reference: <empty> -> 24914122, 25691646
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    pmrB_T92A WP_001212189.1
        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
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        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
    pmrB_V161G WP_001300761.1
        genbank_nucleotide_accession: <empty> -> JUCJ01000016.1
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    pmrB_V161L WP_001212189.1
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        genbank_nucleotide_accession: <empty> -> AACVDW010000008.1
        pubmed_reference: <empty> -> 33321688
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        genbank_nucleotide_accession: <empty> -> UISW01000002.1
        refseq_nucleotide_accession: <empty> -> NZ_UISW01000002.1
    ponA_L421P WP_003687357.1
        genbank_nucleotide_accession: <empty> -> AE004969.1
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    porB1b_A121D WP_106333382.1
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        refseq_nucleotide_accession: <empty> -> NZ_FLKZ01000005.1
    porB1b_A121H WP_106333382.1
        genbank_nucleotide_accession: <empty> -> FLKZ01000005.1
        refseq_nucleotide_accession: <empty> -> NZ_FLKZ01000005.1
    porB1b_A121N WP_106333382.1
        genbank_nucleotide_accession: <empty> -> FLKZ01000005.1
        refseq_nucleotide_accession: <empty> -> NZ_FLKZ01000005.1
    porB1b_A121P WP_106333382.1
        genbank_nucleotide_accession: <empty> -> FLKZ01000005.1
        refseq_nucleotide_accession: <empty> -> NZ_FLKZ01000005.1
    porB1b_G120D WP_106333382.1
        genbank_nucleotide_accession: <empty> -> FLKZ01000005.1
        refseq_nucleotide_accession: <empty> -> NZ_FLKZ01000005.1
    porB1b_G120K WP_106333382.1
        genbank_nucleotide_accession: <empty> -> FLKZ01000005.1
        refseq_nucleotide_accession: <empty> -> NZ_FLKZ01000005.1
    porB1b_G120P WP_106333382.1
        genbank_nucleotide_accession: <empty> -> FLKZ01000005.1
        refseq_nucleotide_accession: <empty> -> NZ_FLKZ01000005.1
    porB1b_G120R WP_106333382.1
        genbank_nucleotide_accession: <empty> -> FLKZ01000005.1
        refseq_nucleotide_accession: <empty> -> NZ_FLKZ01000005.1
    ptsI_V25I WP_000623140.1
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        genbank_nucleotide_accession: <empty> -> CP000647.1
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        genbank_nucleotide_accession: <empty> -> CP001138.1
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        genbank_nucleotide_accession: <empty> -> CP001138.1
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        genbank_nucleotide_accession: <empty> -> CP000647.1
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        genbank_nucleotide_accession: <empty> -> CP001138.1
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        genbank_nucleotide_accession: <empty> -> HE681097.1
        refseq_nucleotide_accession: <empty> -> NC_017763.1
    rplC_G155R WP_000160212.1
        genbank_nucleotide_accession: <empty> -> HE681097.1
        refseq_nucleotide_accession: <empty> -> NC_017763.1
    rplC_M169L WP_000160212.1
        genbank_nucleotide_accession: <empty> -> HE681097.1
        refseq_nucleotide_accession: <empty> -> NC_017763.1
    rplC_S145DEL WP_000160212.1
        genbank_nucleotide_accession: <empty> -> HE681097.1
        refseq_nucleotide_accession: <empty> -> NC_017763.1
    rplD_G70D WP_003690088.1
        genbank_nucleotide_accession: <empty> -> AE004969.1
        refseq_nucleotide_accession: <empty> -> NC_002946.2
    rplV_K83KKGPSLK WP_002215424.1
        genbank_nucleotide_accession: <empty> -> AE002098.2
        refseq_nucleotide_accession: <empty> -> NC_003112.2
    rplV_K90KARAK WP_002215424.1
        genbank_nucleotide_accession: <empty> -> AE002098.2
        refseq_nucleotide_accession: <empty> -> NC_003112.2
    rpoB_A1085V WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_A473AA WP_014614750.1
        genbank_nucleotide_accession: <empty> -> PPRB01000139.1
        refseq_nucleotide_accession: <empty> -> NZ_PPRB01000139.1
    rpoB_A473T WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_A477D WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_A477G WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_A477T WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_A477V WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_A621E WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_D471G WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_D471Y WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_D492N WP_003436174.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoB_D492V WP_003436174.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoB_D550G WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_G158V WP_003690105.1
        genbank_nucleotide_accession: <empty> -> CP001050.1
        refseq_nucleotide_accession: <empty> -> NC_011035.1
    rpoB_H481D WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_H481N WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_H481Y WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_H481Y WP_014614750.1
        genbank_nucleotide_accession: <empty> -> PPRB01000139.1
        refseq_nucleotide_accession: <empty> -> NZ_PPRB01000139.1
    rpoB_H502L WP_003436174.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoB_H502N WP_003436174.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoB_H502Y WP_003436174.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoB_H526Y WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_I527F WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_I527L WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_I527M WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_I572F WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_I572L WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_I572N WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_I953S WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_L466S WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_L533P WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_M470T WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_N474K WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_N474KG WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_N474NH WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_P157L WP_003690105.1
        genbank_nucleotide_accession: <empty> -> CP001050.1
        refseq_nucleotide_accession: <empty> -> NC_011035.1
    rpoB_P496S WP_003436174.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoB_P564L WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_Q1074R WP_003436174.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoB_Q465K WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_Q465R WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_Q468I WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_Q468K WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_Q468L WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_Q468R WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_Q513L WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_Q513P WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_R201H WP_003690105.1
        genbank_nucleotide_accession: <empty> -> CP001050.1
        refseq_nucleotide_accession: <empty> -> NC_011035.1
    rpoB_R484C WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_R484H WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_R505K WP_003436174.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoB_R529C WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_R529S WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_R687H WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_S463N WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_S463P WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_S464P WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_S486L WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_S486L WP_014614750.1
        genbank_nucleotide_accession: <empty> -> PPRB01000139.1
        refseq_nucleotide_accession: <empty> -> NZ_PPRB01000139.1
    rpoB_S488P WP_003436174.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoB_S529L WP_000918664.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoB_S531F WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_S550F WP_003436174.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoB_S550Y WP_003436174.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoB_T563P WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoB_V146F WP_000263098.1
        genbank_nucleotide_accession: <empty> -> CXAL01000043.1
        refseq_nucleotide_accession: <empty> -> NZ_CXAL01000043.1
    rpoC_D245Y WP_003429485.1
        genbank_nucleotide_accession: <empty> -> AM180355.1
        refseq_nucleotide_accession: <empty> -> NC_009089.1
    rpoC_F632S WP_000567963.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoC_Q961K WP_000567963.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    rpoD_DDDA92del WP_003688264.1
        genbank_nucleotide_accession: <empty> -> CP001050.1
        refseq_nucleotide_accession: <empty> -> NC_011035.1
    rpoD_E98K WP_003688264.1
        genbank_nucleotide_accession: <empty> -> CP001050.1
        refseq_nucleotide_accession: <empty> -> NC_011035.1
    rpsE_K28E WP_002215445.1
        genbank_nucleotide_accession: <empty> -> AE002098.2
        refseq_nucleotide_accession: <empty> -> NC_003112.2
    rpsE_T24P WP_002215445.1
        genbank_nucleotide_accession: <empty> -> AE002098.2
        refseq_nucleotide_accession: <empty> -> NC_003112.2
    rpsE_V27del WP_002215445.1
        genbank_nucleotide_accession: <empty> -> AE002098.2
        refseq_nucleotide_accession: <empty> -> NC_003112.2
    rpsJ_V57L WP_001181005.1
        genbank_nucleotide_accession: <empty> -> KC843636.1
    rpsJ_V57L WP_002215394.1
        genbank_nucleotide_accession: <empty> -> AE002098.2
        refseq_nucleotide_accession: <empty> -> NC_003112.2
    rpsJ_V57M WP_002215394.1
        genbank_nucleotide_accession: <empty> -> AE002098.2
        refseq_nucleotide_accession: <empty> -> NC_003112.2
    rpsJ_V57Q WP_002215394.1
        genbank_nucleotide_accession: <empty> -> AE002098.2
        refseq_nucleotide_accession: <empty> -> NC_003112.2
    rpsL_K43R WP_057042458.1
        genbank_nucleotide_accession: <empty> -> AABMHE010000010.1
    rpsL_K88E WP_057042458.1
        genbank_nucleotide_accession: <empty> -> AABMHE010000010.1
    rpsL_K88Q WP_057042458.1
        genbank_nucleotide_accession: <empty> -> AABMHE010000010.1
    rpsL_K88R WP_057042458.1
        genbank_nucleotide_accession: <empty> -> AABMHE010000010.1
    soxR_G121D WP_000412428.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    soxR_G121D WP_000412686.1
        genbank_nucleotide_accession: <empty> -> AL513382.1
        refseq_nucleotide_accession: <empty> -> NC_003198.1
    soxR_R20H WP_000412428.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    soxR_R20H WP_000412686.1
        genbank_nucleotide_accession: <empty> -> AL513382.1
        refseq_nucleotide_accession: <empty> -> NC_003198.1
    soxS_A12S WP_000019358.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    soxS_E52K WP_000019483.1
        genbank_nucleotide_accession: <empty> -> AE006468.2
        refseq_nucleotide_accession: <empty> -> NC_003197.2
    tufA_A376S WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_A376T WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_A376V WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_E379K WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_G317D WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_L121Q WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_Q125E WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_Q125K WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_Q125R WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_Q330H WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_R231C WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_R231V WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_R234F WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_R234S WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_R334C WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_T335A WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_Y161C WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_Y161D WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    tufA_Y161N WP_000031783.1
        genbank_nucleotide_accession: <empty> -> U00096.3
        refseq_nucleotide_accession: <empty> -> NC_000913.3
    uhpA_G97D WP_000633668.1
        genbank_nucleotide_accession: <empty> -> HG738867.1
        refseq_nucleotide_accession: <empty> -> NZ_HG738867.1
    uhpT_E350Q WP_000879194.1
        genbank_nucleotide_accession: <empty> -> HG738867.1
        refseq_nucleotide_accession: <empty> -> NZ_HG738867.1
    uhpT_G112E WP_001008722.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    uhpT_G358V WP_001008722.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    uhpT_W228STOP WP_001008722.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    uhpT_W425R WP_001008722.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    uhpT_Y314STOP WP_001008722.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    walK_L10F WP_000871610.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    walK_R263C WP_000871610.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    walK_S221P WP_000871610.1
        genbank_nucleotide_accession: <empty> -> BX571856.1
        refseq_nucleotide_accession: <empty> -> NC_002952.2
    yybT_I440S WP_002356022.1
        genbank_nucleotide_accession: <empty> -> AE016830.1
        refseq_nucleotide_accession: <empty> -> NC_004668.1

Hierarchy nodes added
    core AMR AMR
        blaBOR           blaBOR NF040659.1              BOR family class A beta-lactamase
        blaGMA           blaGMA NF040812.1              GMA family class A beta-lactamase
        blaHBL           blaHBL                         HBL family class A beta-lactamase
        blaOXA-1089_fam  blaOXA NF040804.1              OXA-1089 family carbapenem-hydrolyzing class D beta-lactamase
        blaOXA-1091_fam  blaOXA NF040803.1              OXA-1091 family class D beta-lactamase
        blaOXA-198_fam   blaOXA NF040806.1              OXA-198 family carbapenem-hydrolyzing class D beta-lactamase
        blaOXA-732_fam   blaOXA NF040805.1              OXA-732 family class D beta-lactamase
        blaOXA-VL06      blaOXA NF040784.1              OXA-1090 family carbapenem-hydrolyzing class D beta-lactamase
        fosY             fosY NF040802.1                fosfomycin resistance bacillithiol transferase FosY
    non-reported VIRULENCE VIRULENCE
        VIRULENCE_Bcer
    plus VIRULENCE VIRULENCE
        alo              alo                            anthrolysin O/cereolysin O family cholesterol-dependent cytolysin Alo
        atxA             atxA                           anthrax toxin expression trans-acting transcriptional regulator AtxA
        bpsA             bpsA                           chain length determinant family protein BpsA
        bpsB             bpsB                           tyrosine-protein kinase BpsB
        bpsC             bpsC                           UTP--glucose-1-phosphate uridylyltransferase BpsC
        bpsD             bpsD                           sugar transferase BpsD
        bpsE             bpsE                           N-acetylneuraminate synthase family protein BpsE
        bpsF             bpsF                           UDP-N-acetylglucosamine 2-epimerase BpsF
        bpsG             bpsG                           acylneuraminate cytidylyltransferase family protein BpsG
        bpsH             bpsH                           oligosaccharide flippase family protein BpsH
        bpsX             bpsX                           LytR family transcriptional regulator BpsX
        capA             capA                           capsular polyglutamate synthetase CapA
        capB             capB                           capsule biosynthesis protein CapB
        capC             capC                           capsular polyglutamate amide ligase/translocase CapC
        capD             capD                           capsule biosynthesis gamma-glutamyltransferase CapD
        capE             capE                           capsule biosynthesis protein CapE
        cerA             cerA                           phospholipase CerA
        cerB             cerB                           sphingomyelinase CerB
        cesA             cesA                           cereulide non-ribosomal peptide synthetase CesA
        cesB             cesB                           cereulide non-ribosomal peptide synthetase CesB
        cesC             cesC                           cereulide export ABC transporter permease ATP-binding protein CesC
        cesD             cesD                           cereulide export ABC transporter permease subunit CesD
        cya              cya                            anthrax toxin edema factor
        cytK1            cytK1                          beta-channel forming cytolysin CytK1
        cytK2            cytK2                          beta-channel forming cytolysin CytK2
        entFM            entFM                          enterotoxin EntFM
        hasA             hasA                           hyaluronan synthase HasA
        hblA             hblA                           hemolytic enterotoxin HBL binding subunit HblA
        hblB             hblB                           hemolytic enterotoxin HBL binding subunit HblB
        hblC             hblC                           hemolytic enterotoxin HBL lytic component L2
        hblD             hblD                           hemolytic enterotoxin HBL lytic component L1
        hlyII            hlyII                          hemolysin II HlyII
        hlyIIR           hlyIIR                         hemolysin II regulator HlyIIR
        inhA1            inhA1                          M6 family metalloprotease immune inhibitor InhA1
        inhA2            inhA2                          M6 family metalloprotease immune inhibitor InhA2
        lef              lef                            anthrax toxin lethal factor
        nheA             nheA                           non-hemolytic enterotoxin NHE subunit A
        nheB             nheB                           non-hemolytic enterotoxin NHE subunit B
        nheC             nheC                           non-hemolytic enterotoxin NHE subunit C
        pagA             pagA                           anthrax toxin protective antigen
        plcA             plcA                           phosphatidylinositol diacylglycerol-lyase
        plcR             plcR                           transcriptional regulator PlcR
        sodC1            sodC1                          superoxide dismutase [Cu-Zn] SodC1
        sph              sph                            sphingomyelinase C
Changed Hierarchy Nodes
    blaOXA-372_fam   OXA-372 family carbapenem-hydrolyzing class D beta-lactamase
        hmm_acc:         NF000415.2 -> NF000415.3
    blaPAM           PAM family subclass B3 metallo-beta-lactamase
        hmm_acc:         <empty> -> NF040644.1
    blaPRC           PRC family class C beta-lactamase
        hmm_acc:         <empty> -> NF038359.1
    blaSFDC          SFDC family class C beta-lactamase
        hmm_acc:         <empty> -> NF038366.1
    espF             type III secretion system LEE effector EspF
        hmm_acc:         <empty> -> NF040807.1
----------------------------------------------------------------------
Changes included in 2021-12-21.1
----------------------------------------------------------------------

Overview:

    - eat(A) (AFC62715.1) was made a non-reportable reference because the
      reference protein does not confer resistance, but a known point mutation
      on that reference does. The resistance point mutation (eatA_T450I in
      Enterococcus faecium) is included in the database.
    - Some protein names were modified slightly to help regularize protein
      names across the database.
    - Several beta-lactamases had updates to their subclasses based on
      publications.
    - New sequences were chosen for several blaB alleles to correct start
      sites. Those show up as removed and added in the lists below because the
      accessions were changed.
    - New linezolid resistant 23S point mutations for Enterococcus_faecium and
      Enterococcus_faecalis were added.
    - Continued curation to add pubmed citations for some genes.
    - A new blaOXA-1043 node (and HMM) were created as part of our efforts to
      better organize blaOXA.
    - Three new families of beta-lactamase were added (blaPRC, blaRASA, and
      blaSHD).
    - Yersinia enterolytica virulence genes were added.
    - dfrC (CAA88269.1 and NF000155.1) was made non-reportable as a gene
      because the reference sequence is sensitive (PMID:7768789), however a
      variant is resistant. We added the variant as a resistant allele.
    - A few 'plus' nodes were added with HMMs only because protein sequences
      that meet our requirements are not available, but we felt the genes were
      sufficiently important to include.
    - The usual addition of new alleles submitted to NCBI for allele
      assignment.

Summary:
   Total proteins: 7036
        Core proteins: 6015
        Plus proteins: 1020
   AMR proteins: 6060
   STRESS proteins: 235
   VIRULENCE proteins: 741
   Point mutations: 918
   Point mutation references: 158
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Clostridioides_difficile,
       Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella,
       Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus,
       Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae,
       Streptococcus_pyogenes
   HMMs: 654

Updates since release 2021-09-30.1:
   Proteins added: 128
       Core proteins added: 100
       Plus proteins added: 28
   AMR proteins added: 101
   STRESS proteins added: 2
   VIRULENCE proteins added: 25
   Alleles added: 100
   Point mutations added: 4
   Proteins removed: 6
       Core proteins removed: 6
       Plus proteins removed: 0
   Reference Gene Catalog entries changed: 25
   Hierarchy nodes added: 36
   Hierarchy nodes removed: 0
   Hierarchy nodes changed: 8

Added proteins
    core AMR AMR
        blaADC-259       NG_078048.1 WP_046882921.1     class C beta-lactamase ADC-259
        blaADC-260       NG_078049.1 WP_231869648.1     class C beta-lactamase ADC-260
        blaAIM-2         NG_078036.1 WP_231869638.1     subclass B3 metallo-beta-lactamase AIM-2
        blaAXC-7         NG_078067.1 WP_231873785.1     carbapenem-hydrolyzing class A beta-lactamase AXC-7
        blaB-10          NG_077980.1 WP_078782085.1     subclass B1 metallo-beta-lactamase BlaB-10
        blaB-14          NG_048696.2 WP_078394827.1     subclass B1 metallo-beta-lactamase BlaB-14
        blaB-7           NG_077981.1 WP_078402391.1     subclass B1 metallo-beta-lactamase BlaB-7
        blaB-8           NG_077979.1 WP_078721108.1     subclass B1 metallo-beta-lactamase BlaB-8
        blaB-9           NG_077978.1 WP_081321989.1     subclass B1 metallo-beta-lactamase BlaB-9
        blaCARB-58       NG_077982.1 WP_231869590.1     PSE family carbenicillin-hydrolyzing class A beta-lactamase CARB-58
        blaCME-3         NG_078057.1 WP_009085188.1     class A extended-spectrum beta-lactamase CME-3
        blaCMH-7         NG_078039.1 WP_231869641.1     class C beta-lactamase CMH-7
        blaCMY-177       NG_078046.1 WP_231869646.1     class C beta-lactamase CMY-177
        blaCMY-179       NG_078068.1 WP_187259226.1     class C beta-lactamase CMY-179
        blaCTX-M-251     NG_078045.1 WP_231869645.1     class A extended-spectrum beta-lactamase CTX-M-251
        blaGES-50        NG_077975.1 WP_231869588.1     carbapenem-hydrolyzing class A beta-lactamase GES-50
        blaGES-51        NG_077976.1 WP_200925854.1     carbapenem-hydrolyzing class A beta-lactamase GES-51
        blaIMI-23        NG_077972.1 WP_223525081.1     carbapenem-hydrolyzing class A beta-lactamase IMI-23
        blaKPC-102       NG_078063.1 WP_231873781.1     carbapenem-hydrolyzing class A beta-lactamase KPC-102
        blaKPC-103       NG_078051.1 WP_231869650.1     class A beta-lactamase KPC-103
        blaKPC-104       NG_078052.1 WP_231869651.1     class A beta-lactamase KPC-104
        blaKPC-105       NG_078054.1 WP_231869653.1     class A beta-lactamase KPC-105
        blaKPC-106       NG_078056.1 WP_231869655.1     class A beta-lactamase KPC-106
        blaKPC-107       NG_078053.1 WP_231869652.1     class A beta-lactamase KPC-107
        blaKPC-108       NG_078055.1 WP_231869654.1     class A beta-lactamase KPC-108
        blaKPC-96        NG_078037.1 WP_231869639.1     carbapenem-hydrolyzing class A beta-lactamase KPC-96
        blaKPC-97        NG_078038.1 WP_231869640.1     class A beta-lactamase KPC-97
        blaKPC-98        NG_078032.1 WP_231869634.1     carbapenem-hydrolyzing class A beta-lactamase KPC-98
        blaMOX-16        NG_077977.1 WP_231869589.1     CMY-1/MOX family class C beta-lactamase MOX-16
        blaNDM-41        NG_078034.1 WP_231869636.1     subclass B1 metallo-beta-lactamase NDM-41
        blaOXA-1000      NG_078021.1 WP_231869625.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1000
        blaOXA-1001      NG_078022.1 WP_042088348.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-1001
        blaOXA-1002      NG_078023.1 WP_231869626.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1002
        blaOXA-1003      NG_078024.1 WP_231869627.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1003
        blaOXA-1004      NG_078025.1 WP_231869628.1     OXA-294 family class D beta-lactamase OXA-1004
        blaOXA-1005      NG_078026.1 WP_163170629.1     OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-1005
        blaOXA-1006      NG_078027.1 WP_231869629.1     class D beta-lactamase OXA-1006
        blaOXA-1007      NG_078028.1 WP_231869630.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1007
        blaOXA-1008      NG_078029.1 WP_231869631.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1008
        blaOXA-1009      NG_078030.1 WP_231869632.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1009
        blaOXA-1010      NG_078031.1 WP_231869633.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-1010
        blaOXA-1038      NG_078041.1 WP_231869643.1     OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-1038
        blaOXA-1039      NG_078042.1 WP_037414505.1     OXA-48 family carbapenem-hydrolyzing class D beta-lactamase OXA-1039
        blaOXA-1040      NG_078047.1 WP_231869647.1     OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-1040
        blaOXA-1041      NG_078050.1 WP_231869649.1     OXA-427 family class D beta-lactamase OXA-1041
        blaOXA-1042      NG_077974.1 WP_231869587.1     OXA-1 family class D beta-lactamase OXA-1042
        blaOXA-1043      NG_077971.1 WP_077021671.1     class D beta-lactamase OXA-1043
        blaOXA-933       NG_077983.1 WP_231869591.1     OXA-48 family class D beta-lactamase OXA-933
        blaOXA-934       NG_077984.1 WP_231869592.1     OXA-48 family class D beta-lactamase OXA-934
        blaOXA-966       NG_077987.1 WP_005405099.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-966
        blaOXA-967       NG_077988.1 WP_231869594.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-967
        blaOXA-968       NG_077989.1 WP_231869595.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-968
        blaOXA-969       NG_077990.1 WP_231869596.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-969
        blaOXA-970       NG_077991.1 WP_231869597.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-970
        blaOXA-971       NG_077992.1 WP_231869598.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-971
        blaOXA-972       NG_077993.1 WP_231869599.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-972
        blaOXA-973       NG_077994.1 WP_231869600.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-973
        blaOXA-974       NG_077995.1 WP_231869601.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-974
        blaOXA-975       NG_077996.1 WP_231869602.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-975
        blaOXA-976       NG_077997.1 WP_001022757.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-976
        blaOXA-977       NG_077998.1 WP_231869603.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-977
        blaOXA-978       NG_077999.1 WP_231869604.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-978
        blaOXA-979       NG_078000.1 WP_231869605.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-979
        blaOXA-980       NG_078001.1 WP_081174195.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-980
        blaOXA-981       NG_078002.1 WP_231869606.1     class D beta-lactamase OXA-981
        blaOXA-982       NG_078003.1 WP_231869607.1     OXA-294 family class D beta-lactamase OXA-982
        blaOXA-983       NG_078004.1 WP_231869608.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-983
        blaOXA-984       NG_078005.1 WP_231869609.1     OXA-294 family class D beta-lactamase OXA-984
        blaOXA-985       NG_078006.1 WP_231869610.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-985
        blaOXA-986       NG_078007.1 WP_231869611.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-986
        blaOXA-987       NG_078008.1 WP_231869612.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-987
        blaOXA-988       NG_078009.1 WP_231869613.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-988
        blaOXA-989       NG_078010.1 WP_231869614.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-989
        blaOXA-990       NG_078011.1 WP_231869615.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-990
        blaOXA-991       NG_078012.1 WP_231869616.1     OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-991
        blaOXA-992       NG_078013.1 WP_231869617.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-992
        blaOXA-993       NG_078014.1 WP_231869618.1     OXA-294 family class D beta-lactamase OXA-993
        blaOXA-994       NG_078015.1 WP_231869619.1     OXA-294 family class D beta-lactamase OXA-994
        blaOXA-995       NG_078016.1 WP_231869620.1     OXA-294 family class D beta-lactamase OXA-995
        blaOXA-996       NG_078017.1 WP_231869621.1     OXA-294 family class D beta-lactamase OXA-996
        blaOXA-997       NG_078018.1 WP_231869622.1     OXA-294 family class D beta-lactamase OXA-997
        blaOXA-998       NG_078019.1 WP_231869623.1     OXA-294 family class D beta-lactamase OXA-998
        blaOXA-999       NG_078020.1 WP_231869624.1     class D beta-lactamase OXA-999
        blaPDC-497       NG_078033.1 WP_231869635.1     class C beta-lactamase PDC-497
        blaPDC-498       NG_078064.1 WP_231873782.1     class C beta-lactamase PDC-498
        blaPDC-499       NG_078065.1 WP_231873783.1     class C beta-lactamase PDC-499
        blaPDC-500       NG_078066.1 WP_231873784.1     inhibitor-resistant class C beta-lactamase PDC-500
        blaPRC-1         NG_077986.1 WP_230924646.1     class C beta-lactamase PRC-1
        blaRASA-1        NG_077969.1 WP_064964747.1     class A extended-spectrum beta-lactamase RASA-1
        blaSFC-3         NG_077966.1 WP_051363721.1     carbapenem-hydrolyzing class A beta-lactamase SFC-3
        blaSHD-1         NG_077967.1 WP_011495276.1     subclass B1 metallo-beta-lactamase SHD-1
        blaVEB-28        NG_077985.1 WP_231869593.1     class A extended-spectrum beta-lactamase VEB-28
        blaVIM-77        NG_078035.1 WP_231869637.1     subclass B1 metallo-beta-lactamase VIM-77
        blaVIM-78        NG_078043.1 WP_142836723.1     subclass B1 metallo-beta-lactamase VIM-78
        blaVIM-79        NG_078044.1 WP_231869644.1     subclass B1 metallo-beta-lactamase VIM-79
        dfrS1            NG_077973.1 WP_000175735.1     trimethoprim-resistant dihydrofolate reductase DfrS1
        npmB1            NG_077965.1 WP_231869586.1     16S rRNA (adenine(1408)-N(1))-methyltransferase NpmB1
        npmB2            NG_077964.1 WP_231869585.1     16S rRNA (adenine(1408)-N(1))-methyltransferase NpmB2
        qnrA13           NG_078040.1 WP_231869642.1     quinolone resistance pentapeptide repeat protein QnrA13
        qnrB97           NG_078069.1 WP_187259598.1     quinolone resistance pentapeptide repeat protein QnrB97
    plus AMR AMR
        emrC             AAAIJS010000026.1 EAC4468893.1 multidrug efflux transporter outer membrane subunit EmrC
    plus STRESS BIOCIDE
        emrE             CP001602.2 ADB68610.1          quaternary ammonium compound efflux SMR transporter EmrE
    plus STRESS METAL
        arsN1            AE015451.2 AAN67541.1          arsinothricin resistance N-acetyltransferase ArsN1 family B
    plus VIRULENCE VIRULENCE
        ystA             U09235.1 AAA18472.1            ST-I family heat-stable enterotoxin YstA
        ail              M29945.1 AAA88694.1            attachment invasion locus protein Ail
        virF             AF102990.1 AAD16833.1          virulence regulon transcriptional activator VirF
        hreP             AF354753.1 AAK40114.1          subtilisin/kexin-like serine protease HreP
        yopD             AF336309.1 AAK69210.1          type III secretion system translocon subunit YopD
        yopB             AF336309.1 AAK69211.1          type III secretion system translocon subunit YopB
        yopJ             AY150843.2 AAN37537.1          YopJ/YopP family T3SS effector serine/threonine acetyltransferase
        ymoA             AY387659.1 AAQ90017.1          expression modulating protein YmoA
        tcbA             AY647257.1 AAT90756.1          Tc family toxin subunit TcbA
        tcaC             AY647257.1 AAT90757.1          Tc family toxin subunit TcaC
        tccC             AY647257.1 AAT90761.1          Tc family toxin RHS repeat subunit TccC
        myfA             JF838170.1 AEO31530.1          fimbrial protein MyfA
        yopM             CP009845.1 AJJ21446.1          type III secretion system effector YopM
        yopH             CP009845.1 AJJ21453.1          T3SS effector protein-tyrosine-phosphatase YopH
        yopT             CP009845.1 AJJ21466.1          T3SS effector cysteine protease YopT
        yopE             CP009845.1 AJJ21471.1          type III secretion system effector GTPase activator YopE
        yopJ             KR088867.1 AKN09807.1          YopJ/YopP family T3SS effector serine/threonine acetyltransferase
        ystB             D88145.1 BAA13544.1            ST-I family heat-stable enterotoxin YstB
        ystC             D63578.1 BAA23656.1            ST-I family heat-stable enterotoxin YstC
        myfA             Z21953.1 CAA79951.1            fimbrial protein MyfA
        inv              HF933206.1 CCV30618.1          autotransporter invasin Inv
        yopO             CGBC01000084.1 CFQ25321.1      type III secretion system effector protein kinase YopO/YpkA
        lcrV             CPVJ01000032.1 CNC59088.1      type III secretion system needle tip protein LcrV
        yadA             CHJR01000063.1 CNC65351.1      trimeric autotransporter adhesin YadA
        yadA             CWIZ01000032.1 CRY27194.1      trimeric autotransporter adhesin YadA
Added point mutations
    core AMR POINT
        23S_G2505A       LINEZOLID Enterococcus_faecium
        23S_G2505A       LINEZOLID Enterococcus_faecalis
        23S_G2576T       LINEZOLID Enterococcus_faecium
        23S_G2576T       LINEZOLID Enterococcus_faecalis
Removed proteins
    core AMR AMR
        dfrC             NG_047752.1 WP_001830952.1     trimethoprim-resistant dihydrofolate reductase DfrC
        blaB-10          NG_048692.1 WP_063857822.1     subclass B1 metallo-beta-lactamase BlaB-10
        blaB-14          NG_048696.1 WP_034848068.1     subclass B1 metallo-beta-lactamase BlaB-14
        blaB-7           NG_048701.1 WP_063857829.1     subclass B1 metallo-beta-lactamase BlaB-7
        blaB-8           NG_048702.1 WP_059324801.1     subclass B1 metallo-beta-lactamase BlaB-8
        blaB-9           NG_048703.1 WP_059154943.1     subclass B1 metallo-beta-lactamase BlaB-9
Changed reference gene catalog records
    blaCME-1 WP_059330348.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaCME-2 WP_063859570.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaCMY-172 WP_215824899.1
        product_name:    class C beta-lactamase CMY-172 -> inhibitor-resistant class C beta-lactamase CMY-172
        pubmed_reference: <empty> -> 34044150
    blaCTX-M-219 WP_110092882.1
        pubmed_reference: <empty> -> 28637339
    blaCTX-M-243 WP_213994580.1
        pubmed_reference: <empty> -> 34865035
    blaGES-49 WP_219860707.1
        subclass:        CEPHALOSPORIN -> CARBAPENEM
    blaKPC-14 WP_063860636.1
        pubmed_reference: <empty> -> 31127297, 32848008
    blaKPC-28 WP_072081992.1
        pubmed_reference: <empty> -> 32848008
    blaKPC-39 WP_128268237.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-39 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-39
        pubmed_reference: <empty> -> 34606331
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-41 WP_148044419.1
        pubmed_reference: <empty> -> 31527032
    blaKPC-49 WP_197749402.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-49 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-49
        pubmed_reference: <empty> -> 33466574
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-50 WP_171476788.1
        pubmed_reference: <empty> -> 32457107
    blaKPC-69 WP_210205486.1
        product_name:    class A beta-lactamase KPC-69 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-69
        pubmed_reference: <empty> -> 34339281
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaOXA-935 WP_141989064.1
        genbank_cds_start: 10289 -> 65493
        genbank_cds_stop: 11089 -> 66293
        genbank_nucleotide_accession: VIHR01000047.1 -> CP083367.1
        genbank_protein_accession: TQH06257.1 -> UBI73554.1
    blaPDC-245 WP_100831609.1
        pubmed_reference: <empty> -> 31636072
    blaPDC-322 WP_138403314.1
        pubmed_reference: <empty> -> 31636072
    blaPDC-346 WP_148044438.1
        pubmed_reference: <empty> -> 31636072
    blaPDC-381 WP_148044467.1
        pubmed_reference: <empty> -> 31636072
    blaPDC-423 WP_134600670.1
        product_name:    class C beta-lactamase PDC-423 -> inhibitor-resistant class C beta-lactamase PDC-423
        pubmed_reference: <empty> -> 31636072
    blaPDC-468 WP_204376241.1
        product_name:    class C beta-lactamase PDC-468 -> inhibitor-resistant class C beta-lactamase PDC-468
        pubmed_reference: <empty> -> 31636072
    blaRSC1-1 WP_128268282.1
        product_name:    RSC1 family class C beta-lactamase -> class C beta-lactamase RSC1-1
    blaRSD1-1 WP_128268283.1
        product_name:    RSD1 family class D beta-lactamase -> class D beta-lactamase RSD1-1
    mcr-9.1 AYW01299.1
        pubmed_reference: 31064835 -> 31064835, 32513803
    mcr-9.2 MBO4175406.1
        pubmed_reference: <empty> -> 32513803
    mcr-9.3 QKF95689.1
        pubmed_reference: <empty> -> 32513803

Hierarchy nodes added
    core AMR AMR
        blaOXA-1043_fam  blaOXA NF040600.1              OXA-1043 family class D beta-lactamase
        blaPRC           blaPRC                         PRC family class C beta-lactamase
        blaRASA          blaRASA NF040609.1             RASA family class A extended-spectrum beta-lactamase
        blaSHD           blaSHD                         SHD family subclass B1 metallo-beta-lactamase
        lnu(E)           lnu(E) NF000478.2              lincosamide nucleotidyltransferase Lnu(E)
        npmB             npmB NF040634.1                16S rRNA (adenine(1408)-N(1))-methyltransferase NpmB
        tet(43)          tet(43) NF012180.1             tetracycline efflux MFS transporter Tet(43)
    non-reported VIRULENCE VIRULENCE
        VIRULENCE_Yersi
    plus AMR AMR
        emrC_Lis         emrC                           multidrug efflux transporter outer membrane subunit EmrC
    plus STRESS BIOCIDE
        emrE_Lis         emrE                           quaternary ammonium compound efflux SMR transporter EmrE
    plus STRESS METAL
        arsN1a           arsN1 NF040503.1               arsinothricin resistance N-acetyltransferase ArsN1 family A
        arsN1b           arsN1 NF040504.1               arsinothricin resistance N-acetyltransferase ArsN1 family B
        arsN2            arsN2 NF040501.1               arsenic resistance N-acetyltransferase ArsN2
        arsN_gen         arsN                           ArsN family N-acetyltransferase
    plus VIRULENCE VIRULENCE
        ail              ail                            attachment invasion locus protein Ail
        hreP             hreP                           subtilisin/kexin-like serine protease HreP
        inv              inv                            autotransporter invasin Inv
        lcrV             lcrV                           type III secretion system needle tip protein LcrV
        myfA             myfA                           fimbrial protein MyfA
        tcaC             tcaC                           Tc family toxin subunit TcaC
        tcbA             tcbA                           Tc family toxin subunit TcbA
        tccC             tccC                           Tc family toxin RHS repeat subunit TccC
        virF_Yersin      virF                           virulence regulon transcriptional activator VirF
        yadA             yadA NF033478.1                trimeric autotransporter adhesin YadA
        ymoA             ymoA                           expression modulating protein YmoA
        yopB             yopB                           type III secretion system translocon subunit YopB
        yopD             yopD                           type III secretion system translocon subunit YopD
        yopE             yopE                           type III secretion system effector GTPase activator YopE
        yopH             yopH                           T3SS effector protein-tyrosine-phosphatase YopH
        yopJ_gen         yopJ NF040632.1                YopJ/YopP family T3SS effector serine/threonine acetyltransferase
        yopM             yopM                           type III secretion system effector YopM
        yopO             yopO                           type III secretion system effector protein kinase YopO/YpkA
        yopT             yopT                           T3SS effector cysteine protease YopT
        ystA             ystA                           ST-I family heat-stable enterotoxin YstA
        ystB             ystB                           ST-I family heat-stable enterotoxin YstB
        ystC             ystC                           ST-I family heat-stable enterotoxin YstC
Changed Hierarchy Nodes
    ADAPTIVE
        node_id:         ADAPTIVE -> AMR-SUSCEPTIBLE
        name:            Families implicated in Adaptive resistance by mutuation -> Families implicated in adaptive resistance by mutation
    bla-A_carba      carbapenem-hydrolyzing class A beta-lactamase
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaCME           CME family class A extended-spectrum beta-lactamase
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    dfrC             trimethoprim-sensitive dihydrofolate reductase DfrC
        class:           TRIMETHOPRIM -> <empty>
        hmm_acc:         NF000155.1 -> <empty>
        name:            trimethoprim-resistant dihydrofolate reductase DfrC -> trimethoprim-sensitive dihydrofolate reductase DfrC
        scope:           core -> non-reported
        subclass:        TRIMETHOPRIM -> <empty>
    pbp              penicillin-binding protein
        parent_node_id:  ADAPTIVE -> AMR-SUSCEPTIBLE
        subtype:         <empty> -> AMR-SUSCEPTIBLE
        type:            <empty> -> AMR
    pbp1a            penicillin-binding protein
        subtype:         <empty> -> AMR-SUSCEPTIBLE
        type:            <empty> -> AMR
    pbp2b            penicillin-binding protein
        subtype:         <empty> -> AMR-SUSCEPTIBLE
        type:            <empty> -> AMR
    pbp2x            penicillin-binding protein
        subtype:         <empty> -> AMR-SUSCEPTIBLE
        type:            <empty> -> AMR

----------------------------------------------------------------------
Changes included in 2021-09-30.1
----------------------------------------------------------------------

NOTE: This database release requires AMRFinderPlus 3.10.16.  If you are using
an older version of the software it will not work with this database version.

To upgrade AMRFinderPlus to version 3.10.16 see the Upgrading instructions on
the wiki: https://github.com/ncbi/amr/wiki/Upgrading

Overview

- The usual addition of new alleles and genes as they are submitted for allele
  assignment or discovered in the literature.
- A reorganization of the blaOXA family structure. Many gene names have changed
  to include/clarify family structure information, but allele and gene symbols
  have not changed.
- Curators reviewed and added many new known point mutations to the taxgroups
  we cover.
- Added point mutations for Clostridioides difficile.
- The previously reportable Enterococcus faecium eat(A) was made not-reportable
  and point mutations associated with resistance were added because the
  reference appears to be sensitive.
- Many refinements of "Subclass" information on resistance spectrum based on
  recent literature.
- FosA naming regularization and reorganization (see curator statement below
  for details).
- A few new families and HMMs (e.g., blaSFC, blaCRP).
- Subclasses with multiple resistances are now presented in alphabetical order.
- The gene associated with the symbol DfrE has changed (see curator statement
  below for details).
- A bug in the code generating the Reference Gene Catalog meant that fusion
  genes sometimes did not include all subclasses for both subunits. This only
  affected the Reference Gene Catalog; AMRFinderPlus results continue to
  include the subclasses for both subunits.
- We added a new hierarchy_node field in the Reference Gene Catalog along with
  a new file ReferenceGeneHierarchy.txt that contains information on the gene
  hierarchy behind the AMRFinderPlus algorithm. This data will be behind a new
  web interface and is a more user-friendly version of some of the data
  contained in the AMRFinderPlus database files.
- A couple of aac(6') sequences were removed because the DNA sequences behind
  them were withdrawn at the request of the submitter and substitutes could not
  be found.
- A blaOXA-664 allele was removed because the sequence is not complete and it
  was not found on any genomes in our system.

Curator statement concerning FosA nomenclature changes

NCBI has improved the annotation of FosA proteins closely related to named
protein alleles FosA5 and FosA6. The names FosA9 and FosA10 may have
conflicting meanings in the literature, but have been entered into our database
as the terms are used in PMID:31511878 and PMID:32431524, respectively, and
then cited in more recent publications. We note that the family of FosA
proteins closely related to FosA5, FosA6, FosA9, and FosA10, which generally
shows pairwise amino acid identity above 94 % between any two members, has
grown to include now over 200 different amino acid sequences, the majority of
which NCBI is giving the protein product name "FosA5 family fosfomycin
resistance glutathione transferase." A new HMM, NF040540, identifies and names
members of the FosA5 family. NCBI recommends against inventing any further
allele names for the FosA5 family, as collisions can and do occur when
researchers attempt to identify the next available unused name, and recommends
that a protein accession number be used instead to refer to specific members of
the family.  New names in the FosA series should be reserved for the purpose of
discussing novel families, as was done with FosA7, founding member of the FosA7
family.

Curator statement concerning DfrE changes

The dihydrofolate reductase given the name "DfrE" in PMID:9869579 (1999) was
properly described there as the typical enzyme intrinsic to Enterococcus
faecalis, sensitive to trimethoprim and incapable of conferring trimethopim
resistance. It has now been removed from the Reference Gene Catalog. Note that
PMID:9869579 also described DfrF, which does confer resistance and which
remains in our database. A more recent article, PMID:34374564 (August 2021)
describes a newly characterized mobile enzyme, observed first in Staphylococcus
sciuri and shown capable of conferring strong resistance to trimethoprim, and
given the name DfrE. Starting with this release, AMRFinderPlus will use the
term DfrE only to refer to the newly described, resistance-conferring enzyme
described in PMID:34374564.


Summary:
   Total proteins: 6914
        Core proteins: 5921
        Plus proteins: 992
   AMR proteins: 5965
   STRESS proteins: 233
   VIRULENCE proteins: 716
   Point mutations: 914
   Point mutation references: 156
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Clostridioides_difficile,
       Enterococcus_faecalis, Enterococcus_faecium, Escherichia, Klebsiella,
       Neisseria, Pseudomonas_aeruginosa, Salmonella, Staphylococcus_aureus,
       Staphylococcus_pseudintermedius, Streptococcus_agalactiae, Streptococcus_pneumoniae,
       Streptococcus_pyogenes
   HMMs: 650

Updates since release 2021-08-11.1:
   Proteins added: 66
       Core proteins added: 46
       Plus proteins added: 19
   AMR proteins added: 47
   STRESS proteins added: 2
   VIRULENCE proteins added: 17
   Alleles added: 44
   Point mutations added: 62
   Proteins removed: 5
       Core proteins removed: 5
   Reference Gene Catalog entries changed: 339
   Families added: 93
   Families removed: 76
   Families changed: 19

Added proteins
    core AMR AMR
        dfrE             NG_076809.1 WP_012655890.1     trimethoprim-resistant dihydrofolate reductase DfrE
        blaRSA1          NG_076853.1 WP_216944871.1     RSA1 family class A beta-lactamase
        blaFRI-11        NG_076847.1 WP_223174987.1     carbapenem-hydrolyzing class A beta-lactamase FRI-11
        blaGOB-52        NG_067223.1 WP_159108984.1     subclass B3 metallo-beta-lactamase GOB-52
        blaIMI-22        NG_076848.1 WP_223174988.1     carbapenem-hydrolyzing class A beta-lactamase IMI-22
        blaNDM-39        NG_076842.1 WP_223146983.1     subclass B1 metallo-beta-lactamase NDM-39
        blaNDM-40        NG_076843.1 WP_223146984.1     subclass B1 metallo-beta-lactamase NDM-40
        blaOXA-1011      NG_076852.1 WP_211816370.1     class D beta-lactamase OXA-1011
        blaOXA-1018      NG_076815.1 WP_223146972.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1018
        blaOXA-1019      NG_076816.1 WP_196658681.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1019
        blaOXA-1020      NG_076817.1 WP_126584556.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1020
        blaOXA-1021      NG_076818.1 WP_121306048.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1021
        blaOXA-1022      NG_076819.1 WP_034027761.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1022
        blaOXA-1023      NG_076820.1 WP_034033411.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1023
        blaOXA-1024      NG_076821.1 WP_058354753.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1024
        blaOXA-1025      NG_076822.1 WP_034025854.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1025
        blaOXA-1026      NG_076823.1 WP_019396295.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1026
        blaOXA-1027      NG_076824.1 WP_058142895.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1027
        blaOXA-1028      NG_076825.1 WP_017002439.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1028
        blaOXA-1029      NG_076826.1 WP_126861771.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1029
        blaOXA-1030      NG_076827.1 WP_023097100.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1030
        blaOXA-1031      NG_076828.1 WP_223146973.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1031
        blaOXA-1032      NG_076829.1 WP_023107469.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1032
        blaOXA-1033      NG_076830.1 WP_033937969.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1033
        blaOXA-1034      NG_076831.1 WP_033887259.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1034
        blaOXA-1035      NG_076840.1 WP_023096365.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1035
        blaOXA-1036      NG_076807.1 WP_104442312.1     carbapenem-hydrolyzing class D beta-lactamase OXA-1036
        blaOXA-1037      NG_076812.1 WP_128296272.1     class D beta-lactamase OXA-1037
        blaPDC-489       NG_076832.1 WP_223146974.1     class C beta-lactamase PDC-489
        blaPDC-490       NG_076833.1 WP_223146975.1     class C beta-lactamase PDC-490
        blaPDC-491       NG_076834.1 WP_223146976.1     class C beta-lactamase PDC-491
        blaPDC-492       NG_076835.1 WP_223146977.1     class C beta-lactamase PDC-492
        blaPDC-493       NG_076836.1 WP_223146978.1     class C beta-lactamase PDC-493
        blaPDC-494       NG_076837.1 WP_223146979.1     class C beta-lactamase PDC-494
        blaPDC-495       NG_076838.1 WP_223146980.1     class C beta-lactamase PDC-495
        blaPDC-496       NG_076839.1 WP_223146981.1     class C beta-lactamase PDC-496
        blaRAA-1         NG_076814.1 WP_061710074.1     extended-spectrum beta-lactamase RAA-1
        blaRSA1-1        NG_076854.1 WP_223292485.1     class A beta-lactamase RSA1-1
        blaSFC-2         NG_076846.1 WP_223174986.1     carbapenem-hydrolyzing class A beta-lactamase SFC-2
        blaSHV-122b      NG_076808.1 WP_223146970.1     class A beta-lactamase SHV-122b
        blaSHV-229       NG_076841.1 WP_223146982.1     class A broad-spectrum beta-lactamase SHV-229
        blaTEM-61        NG_076810.1 WP_188240090.1     class A extended-spectrum beta-lactamase TEM-61
        blaVIM-75        NG_076844.1 WP_213556171.1     subclass B1 metallo-beta-lactamase VIM-75
        blaVIM-76        NG_076811.1 WP_223146971.1     subclass B1 metallo-beta-lactamase VIM-76
        fosA9            NG_076845.1 WP_114473955.1     fosfomycin resistance glutathione transferase FosA9
        qnrB89           NG_076813.1 WP_213133914.1     quinolone resistance pentapeptide repeat protein QnrB89
    non-reported AMR AMR
        eat(A)           CP003351.1 AFC62715.1          ABC-F type ribosomal protection-like protein Eat(A)
    plus STRESS METAL
        merB1            AF138877.1 AAA83978.1          organomercurial lyase MerB1
        merB1            LC152290.1 BAA82061.2          organomercurial lyase MerB1
    plus VIRULENCE VIRULENCE
        etx              M80837.1 AAA23235.1            epsilon toxin type B
        cpe              M98037.1 AAA72120.1            enterotoxin CPE
        cpb2             L77965.1 AAC27654.1            beta-2 toxin CPB2
        cpb2             AY609165.1 AAU14850.1          beta-2 toxin CPB2
        cpb2             AY730636.1 AAW66356.1          beta-2 toxin CPB2
        pfoA             EF165974.1 ABM21538.1          cholesterol-dependent cytolysin perfringolysin O
        netB             EU143239.1 ABW71134.1          necrotizing enteritis toxin NetB
        cpd              EU545552.1 ACD67884.1          beta-channel forming cytolysin CPD
        cpb              KP064404.1 AJI77134.1          beta-channel forming cytolysin CPB
        netF             KP739975.1 AKF16652.1          necrotizing enteritis toxin NetF
        becA             MH900565.1 AYA44302.1          ADP-ribosylating binary toxin enzymatic subunit BecA
        becB             MH900565.1 AYA44303.1          ADP-ribosylating binary toxin binding subunit BecB
        cpa              D32126.1 BAA06852.1            alpha-toxin
        tpeL             AB262081.1 BAF46125.1          glycosylating toxin TpeL
        iap              X73562.1 CAA51959.1            ADP-ribosylating binary toxin iota enzymatic subunit Ia
        ibp              X73562.1 CAA51960.1            ADP-ribosylating binary toxin iota binding subunit Ib
Added point mutations
    core AMR POINT
        23S_C658T        CLINDAMYCIN/ERYTHROMYCIN Clostridioides_difficile
        cdsA_D222N       DAPTOMYCIN Streptococcus_pneumoniae
        eatA_T450I       PLEUROMUTILIN Enterococcus_faecium
        fabI_F203V       TRICLOSAN Escherichia
        fabI_M159T       TRICLOSAN Escherichia
        ftsI_I336IKYRI   AZTREONAM Escherichia
        ftsI_I336IPYRI   AZTREONAM Escherichia
        ftsI_N337NYRIN   AZTREONAM Escherichia
        fusA_H457L       FUSIDIC ACID Staphylococcus_aureus
        fusA_H457N       FUSIDIC ACID Staphylococcus_aureus
        glpT_A100V       FOSFOMYCIN Staphylococcus_aureus
        glpT_E448K       FOSFOMYCIN Escherichia
        glpT_W355STOP    FOSFOMYCIN Staphylococcus_aureus
        gyrA_A118S       QUINOLONE Clostridioides_difficile
        gyrA_A118T       QUINOLONE Clostridioides_difficile
        gyrA_A384D       QUINOLONE Clostridioides_difficile
        gyrA_D71G        QUINOLONE Clostridioides_difficile
        gyrA_D71V        QUINOLONE Clostridioides_difficile
        gyrA_D81N        QUINOLONE Clostridioides_difficile
        gyrA_E88A        QUINOLONE Staphylococcus_aureus
        gyrA_T82A        QUINOLONE Clostridioides_difficile
        gyrA_T82I        QUINOLONE Clostridioides_difficile
        gyrA_T82V        QUINOLONE Clostridioides_difficile
        gyrB_D426N       QUINOLONE Clostridioides_difficile
        gyrB_D426V       QUINOLONE Clostridioides_difficile
        gyrB_E466K       QUINOLONE Clostridioides_difficile
        gyrB_E466V       QUINOLONE Clostridioides_difficile
        gyrB_I139R       QUINOLONE Clostridioides_difficile
        gyrB_R377G       QUINOLONE Clostridioides_difficile
        gyrB_R447K       QUINOLONE Clostridioides_difficile
        gyrB_R447L       QUINOLONE Clostridioides_difficile
        gyrB_S366A       QUINOLONE Clostridioides_difficile
        gyrB_S366V       QUINOLONE Clostridioides_difficile
        gyrB_S416A       QUINOLONE Clostridioides_difficile
        gyrB_V130I       QUINOLONE Clostridioides_difficile
        lpxA_D233STOP    COLISTIN Acinetobacter_baumannii
        lpxA_G68D        COLISTIN Acinetobacter_baumannii
        lpxA_H159D       COLISTIN Acinetobacter_baumannii
        lpxA_Q72K        COLISTIN Acinetobacter_baumannii
        lpxC_P30L        COLISTIN Acinetobacter_baumannii
        mexZ_G46S        CEPHALOSPORIN Pseudomonas_aeruginosa
        mexZ_Q10STOP     CEPHALOSPORIN Pseudomonas_aeruginosa
        mexZ_V43A        CEPHALOSPORIN Pseudomonas_aeruginosa
        murA_L42STOP     FOSFOMYCIN Staphylococcus_aureus
        murG_P107L       VANCOMYCIN Clostridioides_difficile
        nfsA_E223STOP    NITROFURANTOIN Escherichia
        ompK36_G133D     CARBAPENEM Klebsiella
        pbp4_E218K       CEPHALOSPORIN Staphylococcus_aureus
        pbp4_R200L       CEPHALOSPORIN Staphylococcus_aureus
        pbp4_T-266A      CEPHALOSPORIN Staphylococcus_aureus
        rpoB_D492N       RIFAXIMIN Clostridioides_difficile
        rpoB_D492V       RIFAXIMIN Clostridioides_difficile
        rpoB_H502L       RIFAXIMIN Clostridioides_difficile
        rpoB_H502N       RIFAMPIN Clostridioides_difficile
        rpoB_H502Y       RIFAXIMIN Clostridioides_difficile
        rpoB_P496S       RIFAMYCIN Clostridioides_difficile
        rpoB_Q1074R      FIDAXOMICIN Clostridioides_difficile
        rpoB_R505K       RIFAMPIN Clostridioides_difficile
        rpoB_S488P       RIFAMYCIN Clostridioides_difficile
        rpoB_S550F       RIFAXIMIN Clostridioides_difficile
        rpoB_S550Y       RIFAXIMIN Clostridioides_difficile
        rpoC_D245Y       VANCOMYCIN Clostridioides_difficile
Removed proteins
    core AMR AMR
        eat(A)           NG_047762.1 WP_002296175.1     ABC-F type ribosomal protection protein Eat(A) (moved to non-reported, NG_ record removed)
        dfrE             NG_055770.1 WP_010710386.1     trimethoprim-resistant dihydrofolate reductase DfrE
        aac(6')          NG_052532.1 WP_018893623.1     aminoglycoside 6'-N-acetyltransferase
        aac(6')          NG_052293.1 WP_037790839.1     aminoglycoside 6'-N-acetyltransferase
        blaOXA-664       NG_062213.1 WP_016168805.1     carbapenem-hydrolyzing class D beta-lactamase OXA-664
Changed reference gene catalog records
    lmrS AAW38464.1
        subclass:        ERYTHROMYCIN/CHLORAMPHENICOL -> CHLORAMPHENICOL/ERYTHROMYCIN
    arsR AET17094.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    glpT_F3I WP_001010111.1
        refseq_protein_accession: WP_001010116.1 -> WP_001010111.1
    glpT_G352D WP_001010111.1
        refseq_protein_accession: WP_001010116.1 -> WP_001010111.1
    glpT_L27F WP_001010111.1
        refseq_protein_accession: WP_001010116.1 -> WP_001010111.1
    glpT_V213I WP_001010111.1
        refseq_protein_accession: WP_001010116.1 -> WP_001010111.1
    glpT_W137R WP_001010111.1
        refseq_protein_accession: WP_001010116.1 -> WP_001010111.1
    cfr WP_001010505.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    aac(6')-Ie/aph(2'')-Ia WP_001028144.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    ant(3'')-IIa WP_001112624.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIa WP_001279062.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIa WP_001279068.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIa WP_001279073.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    cfr(B) WP_002349981.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    cfr(B) WP_002405682.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    fosA WP_004146118.1
        product_name:    FosA family fosfomycin resistance glutathione transferase -> FosA5 family fosfomycin resistance glutathione transferase
    ant(3'')-IIc WP_004680079.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIc WP_004758588.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIb WP_004773276.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-IIc WP_005001597.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    fos WP_005475717.1
        product_name:    FosG/FosC2 family fosfomycin resistance glutathione transferase -> FosG/FosC2-related fosfomycin resistance glutathione transferase
    fosA WP_009486251.1
        product_name:    FosA family fosfomycin resistance glutathione transferase -> FosA5 family fosfomycin resistance glutathione transferase
    clbB WP_011245929.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    cfr WP_011987126.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    clbA WP_012116915.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    aac(6')-Ie/aph(2'')-Ia WP_012655884.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    ant(3'')-IIa WP_014208115.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    cipA WP_015735625.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    clbC WP_015892743.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    vanA-Ao2 WP_016331865.1
        gene_family:     vanAo2 -> vanA-Ao2
    aac(6')-Ie/aph(2'')-Ia WP_032490744.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    cfr WP_032491462.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    aadA27 WP_050041693.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    aac(6')-Ie/aph(2'')-If2 WP_057097547.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    aac(3)-Ib/aac(6')-Ib'' WP_063838852.1
        subclass:        KANAMYCIN/TOBRAMYCIN -> GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    aac(6')-30/aac(6')-Ib' WP_063838853.1
        subclass:        GENTAMICIN -> AMINOGLYCOSIDE/GENTAMICIN
    ant(3'')-Ij/aac(6')-Ib WP_063839875.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> GENTAMICIN/SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-Ih/aac(6')-IId WP_063839878.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> AMINOGLYCOSIDE/SPECTINOMYCIN/STREPTOMYCIN
    arr WP_063842202.1
        product_name:    NAD(+)--rifampin ADP-ribosyltransferase -> NAD(+)--rifampin ADP-ribosyltransferase Arr-2b
    rgt WP_063854815.1
        product_name:    rifamycin-inactivating glycosyltransferase Rgt -> Rgt1438 family rifamycin-inactivating glycosyltransferase
    vanY-N WP_063856825.1
        gene_family:     vanY -> vanY-N
        product_name:    VanY-like protein -> D,D-peptidase/D,D-carboxypeptidase VanY-N
    ant(3'')-Ij/aac(6')-IIa WP_070342373.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> GENTAMICIN/KANAMYCIN/SPECTINOMYCIN/STREPTOMYCIN/TOBRAMYCIN
    catB8/aac(6')-Ib' WP_071593228.1
        class:           AMINOGLYCOSIDE -> AMINOGLYCOSIDE/PHENICOL
        subclass:        GENTAMICIN -> AMINOGLYCOSIDE/CHLORAMPHENICOL/GENTAMICIN
    aac(6')-Ib-cr WP_071846215.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    ant(3'')-Ia WP_071846263.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-Ia WP_071846264.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    ant(3'')-Ia WP_071846265.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    cfr(E) WP_105119688.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    cfr(D) WP_105459893.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    cfr(B) WP_111690897.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    cfr(C) WP_111690898.1
        class:           MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
        subclass:        MACROLIDE/LINCOSAMIDE/STREPTOGRAMIN -> LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN
    aac(6')-Ie/aph(2'') WP_122630840.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
    ant(3'')-Ib WP_149316740.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    16S_C1191T NZ_AP019853.2
        pubmed_reference: <empty> -> 2138078
    23S_A2045G NC_002946.2
        pubmed_reference: <empty> -> 20585125
    23S_A2057G NC_002946.2
        pubmed_reference: <empty> -> 30917979
    23S_A2114G NZ_CP018347.1
        pubmed_reference: <empty> -> 10898684
    23S_A2115G NZ_CP018347.1
        pubmed_reference: <empty> -> 10898684
    23S_A2118G NZ_CP018347.1
        pubmed_reference: <empty> -> 11120988
    23S_A2145G NC_002946.2
        pubmed_reference: <empty> -> 31040249
    23S_C2597T NC_002946.2
        pubmed_reference: <empty> -> 12183262
    23S_C2630A NZ_CP018347.1
        pubmed_reference: <empty> -> 10898684
    23S_C2630G NZ_CP018347.1
        pubmed_reference: <empty> -> 10898684
    aac(6')-Ib-cr10 WP_124042715.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr11 WP_159241551.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr3 WP_071766621.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr4 WP_065187000.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr5 WP_063840321.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr6 WP_063840320.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr7 WP_071766399.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr8 WP_151346866.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aac(6')-Ib-cr9 WP_131534982.1
        subclass:        AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE -> AMIKACIN/KANAMYCIN/QUINOLONE/TOBRAMYCIN
    aadA14 WP_011264082.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    aadA17 WP_063840416.1
        subclass:        STREPTOMYCIN/SPECTINOMYCIN -> SPECTINOMYCIN/STREPTOMYCIN
    acrB_R620C WP_086259262.1
        pubmed_reference: <empty> -> 30519062
    acrB_R717L WP_001132507.1
        pubmed_reference: <empty> -> 31730615
    acrB_R717Q WP_001132507.1
        pubmed_reference: <empty> -> 31730615
    acrR_M109I WP_002892080.1
        pubmed_reference: <empty> -> 25182649
    acrR_V165I WP_002892080.1
        pubmed_reference: <empty> -> 25182649
    acrR_Y114F WP_002892080.1
        pubmed_reference: <empty> -> 25182649
    adeR_A91V WP_031379794.1
        pubmed_reference: <empty> -> 27247231
    adeR_D20N WP_031379794.1
        pubmed_reference: <empty> -> 20921306
    adeR_E219A WP_031379794.1
        pubmed_reference: <empty> -> 23587960
    adeR_L192R WP_031379794.1
        pubmed_reference: <empty> -> 23587960
    adeR_P116L WP_031379794.1
        pubmed_reference: <empty> -> 15328088
    adeR_P56S WP_031379794.1
        pubmed_reference: <empty> -> 23587960
    adeS_G336S WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_H189Y WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_I252S WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_N125K WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_Q163STOP WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_R152K WP_031379793.1
        pubmed_reference: <empty> -> 23587960
    adeS_T153M WP_031379793.1
        pubmed_reference: <empty> -> 15328088
    ampC_C-11T NZ_CP041538.1
        pubmed_reference: <empty> -> 12234856
    ampC_C-42A NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampC_C-42G NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampC_C-42T NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampC_T-32A NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampC_T-32C NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampC_T-32G NZ_CP041538.1
        pubmed_reference: <empty> -> 21653764, 7010184
    ampD_H77Y WP_003112844.1
        pubmed_reference: <empty> -> 27736752
    ampD_T139M WP_003112844.1
        pubmed_reference: <empty> -> 27736752
    ampR_D135G WP_003137572.1
        pubmed_reference: <empty> -> 25182487
    ampR_G154R WP_003137572.1
        pubmed_reference: <empty> -> 23045355
    basR_G15R WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53A WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53C WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53E WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53R WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53S WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53V WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_G53W WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    basR_L105P WP_094970923.1
        pubmed_reference: <empty> -> 29914952
    basR_R81L WP_094970923.1
        pubmed_reference: <empty> -> 30863849
    blaB-28 WP_107808007.1
        genbank_nucleotide_accession: QAXV01000003.1 -> QBUH01000004.1
        refseq_nucleotide_accession: NG_067981.1 -> NG_076849.1
    blaGES-15 WP_063860503.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase GES-15 -> class A extended-spectrum beta-lactamase GES-15
        pubmed_reference: <empty> -> 34125593
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaGOB-34 WP_107809858.1
        genbank_nucleotide_accession: QAXV01000011.1 -> QBUH01000010.1
        genbank_protein_accession: PTW00275.1 -> PUB26722.1
        refseq_nucleotide_accession: NG_068000.1 -> NG_076850.1
    blaKPC-29 WP_096807439.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-29 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-29
        pubmed_reference: <empty> -> 34339281
    blaKPC-31 WP_073668892.1
        product_name:    inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-31 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-31
        pubmed_reference: <empty> -> 34339281
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-66 WP_188331871.1
        pubmed_reference: <empty> -> 34339281
    blaKPC-67 WP_210204487.1
        product_name:    class A beta-lactamase KPC-67 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-67
        pubmed_reference: <empty> -> 34339281
    blaKPC-68 WP_210204468.1
        product_name:    class A beta-lactamase KPC-68 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-68
        pubmed_reference: <empty> -> 34339281
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-70 WP_210205477.1
        product_name:    class A beta-lactamase KPC-70 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-70
        pubmed_reference: <empty> -> 34339281
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaOXA-118 WP_063861020.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-118 -> OXA-46 family oxacillin-hydrolyzing class D beta-lactamase OXA-118
    blaOXA-119 WP_032490445.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-119 -> OXA-46 family oxacillin-hydrolyzing class D beta-lactamase OXA-119
    blaOXA-185 WP_063861300.1
        product_name:    OXA-184 class D beta-lactamase OXA-185 -> OXA-184 family class D beta-lactamase OXA-185
    blaOXA-205 WP_063861588.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-205 -> OXA-46 family oxacillin-hydrolyzing class D beta-lactamase OXA-205
    blaOXA-427 WP_096807440.1
        pubmed_reference: <empty> -> 34427311
    blaOXA-43 WP_063862921.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-43 -> OXA-42 family oxacillin-hydrolyzing class D beta-lactamase OXA-43
    blaOXA-57 WP_004547230.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-57 -> OXA-42 family oxacillin-hydrolyzing class D beta-lactamase OXA-57
    blaOXA-59 WP_004524931.1
        product_name:    oxacillin-hydrolyzing class D beta-lactamase OXA-59 -> OXA-42 family oxacillin-hydrolyzing class D beta-lactamase OXA-59
    blaOXA-896 WP_156404658.1
        product_name:    class D beta-lactamase OXA-896 -> OXA-9 family oxacillin-hydrolyzing class D beta-lactamase OXA-896
    blaOXA-917 WP_161507793.1
        product_name:    carbapenem-hydrolyzing class D beta-lactamase OXA-917 -> OXA-427 family carbapenem-hydrolyzing class D beta-lactamase OXA-917
    blaSIM-1 WP_017901052.1
        pubmed_reference: 16251286 -> 16251286, 34339276
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaSIM-2 WP_063864722.1
        pubmed_reference: <empty> -> 34339276
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaSPR-1 WP_012145975.1
        subclass:        CARBAPENEM -> BETA-LACTAM
    cvaC CAA40746.1
        genbank_protein_accession: P22522.1 -> CAA40746.1
        genbank_nucleotide_accession: <empty> -> X57525.1
    dacB_G437D WP_003091272.1
        pubmed_reference: <empty> -> 30189050
    dacB_T428P WP_003091272.1
        pubmed_reference: <empty> -> 30189050, 32814972
    dacB_W459STOP WP_003091272.1
        pubmed_reference: <empty> -> 30189050
    emrR_L113P WP_000378442.1
        pubmed_reference: <empty> -> 31633764
    emrR_L64R WP_000378442.1
        pubmed_reference: <empty> -> 31633764
    folP_F25I WP_011017740.1
        pubmed_reference: <empty> -> 9593127
    folP_R228S WP_003702942.1
        pubmed_reference: <empty> -> 15673729
    fosA10 WP_004214174.1
        allele:          <empty> -> fosA10
        product_name:    FosA family fosfomycin resistance glutathione transferase -> fosfomycin resistance glutathione transferase FosA10
    ftsI_A515V WP_000227936.1
        pubmed_reference: <empty> -> 29547094
    glpT_T211P WP_003096330.1
        pubmed_reference: <empty> -> 27736752
    grlA_D84G WP_019167736.1
        pubmed_reference: <empty> -> 18305127
    grlA_D84H WP_019167736.1
        pubmed_reference: <empty> -> 18305127
    grlA_D84N WP_019167736.1
        pubmed_reference: <empty> -> 18305127
    grlA_D84Y WP_019167736.1
        pubmed_reference: <empty> -> 18305127
    grlA_S80I WP_019167736.1
        pubmed_reference: <empty> -> 18305127
    grlA_S80R WP_019167736.1
        pubmed_reference: <empty> -> 18305127
    gyrA_A119E WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_A119S WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_A119V WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_A131G WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_A67P WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_D72G WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_D82G WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_D82N WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_D87G WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_D87G WP_003091448.1
        pubmed_reference: <empty> -> 8540700
    gyrA_D87H WP_003091448.1
        pubmed_reference: <empty> -> 8540700
    gyrA_D87K WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_D87N WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_D87N WP_003091448.1
        pubmed_reference: <empty> -> 8540700
    gyrA_D87Y WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_D95A WP_003688895.1
        pubmed_reference: <empty> -> 7830580
    gyrA_D95G WP_003688895.1
        pubmed_reference: <empty> -> 7830580
    gyrA_D95N WP_003688895.1
        pubmed_reference: <empty> -> 7830580
    gyrA_E139A WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_E88G WP_103263503.1
        pubmed_reference: <empty> -> 18305127
    gyrA_E88K WP_103263503.1
        pubmed_reference: <empty> -> 18305127
    gyrA_G79C WP_000116450.1
        pubmed_reference: <empty> -> 15282231
    gyrA_G81C WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_G81D WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_G81H WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_G81S WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_H80R WP_003091448.1
        pubmed_reference: <empty> -> 22821356
    gyrA_L98V WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_S81L WP_000116450.1
        pubmed_reference: <empty> -> 15282231
    gyrA_S83A WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_S83F WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_S83I WP_001281271.1
        pubmed_reference: <empty> -> 33877914
    gyrA_S83Y WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrA_S84A WP_103263503.1
        pubmed_reference: <empty> -> 18305127
    gyrA_S84L WP_103263503.1
        pubmed_reference: <empty> -> 18305127
    gyrA_S84W WP_103263503.1
        pubmed_reference: <empty> -> 18305127
    gyrA_S85A WP_103263503.1
        pubmed_reference: <empty> -> 18305127
    gyrA_S91F WP_003688895.1
        pubmed_reference: <empty> -> 7830580
    gyrA_S97P WP_001281271.1
        pubmed_reference: <empty> -> 27559761
    gyrA_T83I WP_003091448.1
        pubmed_reference: <empty> -> 8540700
    gyrA_V73I WP_001281271.1
        pubmed_reference: <empty> -> 15848289
    gyrB_D429N WP_050171206.1
        pubmed_reference: <empty> -> 31730160
    gyrB_E466D WP_000072047.1
        pubmed_reference: <empty> -> 19104017
    gyrB_K450N WP_050171206.1
        pubmed_reference: <empty> -> 31730160
    gyrB_K450T WP_050171206.1
        pubmed_reference: <empty> -> 31730160
    gyrB_R438L WP_000072047.1
        pubmed_reference: <empty> -> 15848289
    gyrB_Y421C WP_000072047.1
        pubmed_reference: <empty> -> 15848289
    lon_P403L WP_001295325.1
        pubmed_reference: <empty> -> 30519062
    macAB_G-48T NZ_AP023073.1
        pubmed_reference: <empty> -> 16162665
    marR_R77L WP_000843414.1
        pubmed_reference: <empty> -> 8383113
    mexB_V45L WP_003107312.1
        pubmed_reference: <empty> -> 27736752
    mexD_Q178R WP_003112801.1
        pubmed_reference: <empty> -> 34060900
    mexD_S133G WP_003112801.1
        pubmed_reference: <empty> -> 34060900
    mexZ_G195E WP_003088626.1
        pubmed_reference: <empty> -> 23045355
    mtrC_C-120T NZ_CP012026.1
        pubmed_reference: <empty> -> 21933917
    mtrR_A-53del NZ_CP043871.1
        pubmed_reference: <empty> -> 12493797, 12270819, 30087172
    mtrR_A-56C NZ_CP043871.1
        pubmed_reference: <empty> -> 30087172
    mtrR_A39T WP_047924300.1
        pubmed_reference: <empty> -> 18761689
    mtrR_G-131A NZ_CP043871.1
        pubmed_reference: <empty> -> 18761689
    mtrR_G45D WP_047924300.1
        pubmed_reference: <empty> -> 18761689
    norM_A-7G NZ_AP023073.1
        pubmed_reference: <empty> -> 12533487
    norM_C-104T NZ_AP023073.1
        pubmed_reference: <empty> -> 12533487
    ompK35_E132K WP_004141771.1
        pubmed_reference: <empty> -> 20660684
    ompK35_W230STOP WP_004141771.1
        pubmed_reference: <empty> -> 34060914
    ompK36_D135DGD WP_002913005.1
        pubmed_reference: <empty> -> 30875398, 31477712
    ompK36_E78STOP WP_002913005.1
        pubmed_reference: <empty> -> 20660684
    ompK36_T126STOP WP_002913005.1
        pubmed_reference: <empty> -> 20660684
    ompK36_T136TDT WP_002913005.1
        pubmed_reference: <empty> -> 30875398, 31477712
    ompK36_T192del WP_002913005.1
        pubmed_reference: <empty> -> 20660684
    ompK36_T261STOP WP_002913005.1
        pubmed_reference: <empty> -> 20660684
    ompK36_T333N WP_002913005.1
        pubmed_reference: <empty> -> 28739787
    ompK36_W125STOP WP_002913005.1
        pubmed_reference: <empty> -> 34060914
    oprD_Q142STOP WP_003112576.1
        pubmed_reference: <empty> -> 27736752
    oprD_W138STOP WP_003112576.1
        pubmed_reference: <empty> -> 27736752
    oqxR_D95E WP_000888203.1
        pubmed_reference: <empty> -> 22644028
    oqxR_F6S WP_000888203.1
        pubmed_reference: <empty> -> 22644028
    oqxR_Q11L WP_000888203.1
        pubmed_reference: <empty> -> 22644028
    oqxR_V102G WP_000888203.1
        pubmed_reference: <empty> -> 25193085
    oqxR_V113I WP_000888203.1
        pubmed_reference: <empty> -> 22644028
    parC_D83H WP_001836116.1
        pubmed_reference: <empty> -> 8913454
    parC_D86N WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_E84G WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parC_E84K WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parC_E88K WP_000202259.1
        pubmed_reference: <empty> -> 24159468
    parC_E91G WP_010951227.1
        pubmed_reference: <empty> -> 12529019
    parC_E91K WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_G78D WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parC_S79F WP_001836116.1
        pubmed_reference: <empty> -> 8913454
    parC_S79Y WP_001836116.1
        pubmed_reference: <empty> -> 8913454
    parC_S80I WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parC_S80R WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parC_S84F WP_000202259.1
        pubmed_reference: <empty> -> 24159468
    parC_S84L WP_000202259.1
        pubmed_reference: <empty> -> 27175500
    parC_S84W WP_000202259.1
        pubmed_reference: <empty> -> 24159468
    parC_S87I WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_S87L WP_003095687.1
        pubmed_reference: <empty> -> 31685471
    parC_S87N WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_S87R WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_S88P WP_010951227.1
        pubmed_reference: <empty> -> 7830580
    parC_T66I WP_001281910.1
        pubmed_reference: <empty> -> 15848289
    parE_A473V WP_003102062.1
        pubmed_reference: <empty> -> 23274661
    parE_A499T WP_000195318.1
        pubmed_reference: <empty> -> 15848289
    parE_E454G WP_000195318.1
        pubmed_reference: <empty> -> 15848289
    parE_G410V WP_003691666.1
        pubmed_reference: <empty> -> 12529019
    parE_H462Y WP_000195318.1
        pubmed_reference: <empty> -> 15848289
    parE_M437I WP_003102062.1
        pubmed_reference: <empty> -> 23274661
    parE_M438I WP_000195318.1
        pubmed_reference: <empty> -> 26683630
    parE_S458P WP_000195318.1
        pubmed_reference: <empty> -> 15848289
    parE_V461G WP_000195318.1
        pubmed_reference: <empty> -> 19104017
    parE_V514G WP_000195318.1
        pubmed_reference: <empty> -> 15848289
    parE_V521F WP_000195318.1
        pubmed_reference: <empty> -> 26683630
    pbp2x_P601L WP_032462817.1
        pubmed_reference: <empty> -> 31996443
    pbp2x_Q557E WP_017647104.1
        pubmed_reference: <empty> -> 18541727
    penA_A311V WP_003693546.1
        pubmed_reference: <empty> -> 23587946, 22155830
    penA_A501AA WP_003693546.1
        pubmed_reference: <empty> -> 34013864
    penA_A501P WP_003693546.1
        pubmed_reference: <empty> -> 20704258, 22155830
    penA_A501T WP_003693546.1
        pubmed_reference: <empty> -> 20704258, 23587946
    penA_A501V WP_003693546.1
        pubmed_reference: <empty> -> 20704258
    penA_A510V WP_003693546.1
        pubmed_reference: <empty> -> 27690121
    penA_A516G WP_003693546.1
        pubmed_reference: <empty> -> 27690121
    penA_D346DD WP_003693546.1
        pubmed_reference: <empty> -> 20704258, 23587946
    penA_F504L WP_003693546.1
        pubmed_reference: <empty> -> 27690121
    penA_G542S WP_003693546.1
        pubmed_reference: <empty> -> 20511367
    penA_G545S WP_003693546.1
        pubmed_reference: <empty> -> 20704258, 22155830
    penA_I312M WP_003693546.1
        pubmed_reference: <empty> -> 23587946, 20704258, 22155830
    penA_N512Y WP_003693546.1
        pubmed_reference: <empty> -> 27690121
    penA_P551L WP_003693546.1
        pubmed_reference: <empty> -> 20511367
    penA_P551S WP_003693546.1
        pubmed_reference: <empty> -> 20704258, 23587946
    penA_T483S WP_003693546.1
        pubmed_reference: <empty> -> 23587946
    penA_V316P WP_003693546.1
        pubmed_reference: <empty> -> 23587946
    penA_V316T WP_003693546.1
        pubmed_reference: <empty> -> 23587946, 20704258, 22155830
    phoP_A110V WP_003082436.1
        pubmed_reference: <empty> -> 24412662
    phoP_R117L WP_003082436.1
        pubmed_reference: <empty> -> 24412662
    phoQ_K123Q WP_003082438.1
        pubmed_reference: <empty> -> 24412662
    phoQ_V260G WP_003082438.1
        pubmed_reference: <empty> -> 24412662
    pmrB_A159P WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_A159V WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_C84R WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_C84Y WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_E121K WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_E121Q WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_E166K WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_G206D WP_001300761.1
        pubmed_reference: <empty> -> 29914952
    pmrB_L10P WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_L10R WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_L14R WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_P94L WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_P94Q WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_P94S WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_T147A WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    pmrB_T156M WP_001300761.1
        pubmed_reference: <empty> -> 30863849
    ponA_L421P WP_003687357.1
        pubmed_reference: <empty> -> 11850260
    porB1b_A121D WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_A121H WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_A121N WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_A121P WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_G120D WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_G120K WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_G120P WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    porB1b_G120R WP_106333382.1
        pubmed_reference: <empty> -> 12183233
    ramR_A16D WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    ramR_A183D WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    ramR_A19V WP_004176968.1
        pubmed_reference: <empty> -> 21514798
    ramR_I88N WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    ramR_K5E WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    ramR_T162I WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    ramR_T43M WP_004176968.1
        pubmed_reference: <empty> -> 25182649
    rplD_G70D WP_003690088.1
        pubmed_reference: <empty> -> 33097713
    rplV_K83KKGPSLK WP_002215424.1
        pubmed_reference: <empty> -> 27638945
    rplV_K90KARAK WP_002215424.1
        pubmed_reference: <empty> -> 27638945
    rpoB_A473AA WP_014614750.1
        pubmed_reference: <empty> -> 18305127
    rpoB_G158V WP_003690105.1
        pubmed_reference: <empty> -> 32011233
    rpoB_H481Y WP_014614750.1
        pubmed_reference: <empty> -> 18305127
    rpoB_P157L WP_003690105.1
        pubmed_reference: <empty> -> 32011233
    rpoB_R201H WP_003690105.1
        pubmed_reference: <empty> -> 32011233
    rpoB_S486L WP_014614750.1
        pubmed_reference: <empty> -> 18305127
    rpoC_F632S WP_000567963.1
        product_name:    DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoC
    rpoC_Q961K WP_000567963.1
        product_name:    DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoC
    rpoD_DDDA92del WP_003688264.1
        pubmed_reference: <empty> -> 32011233
    rpoD_E98K WP_003688264.1
        pubmed_reference: <empty> -> 32011233
    rpsE_K28E WP_002215445.1
        pubmed_reference: <empty> -> 23183436
    rpsE_T24P WP_002215445.1
        pubmed_reference: <empty> -> 23183436
    rpsE_V27del WP_002215445.1
        pubmed_reference: <empty> -> 23183436
    rpsJ_V57L WP_001181005.1
        pubmed_reference: <empty> -> 30268919
    rpsJ_V57L WP_002215394.1
        pubmed_reference: <empty> -> 16189114
    rpsJ_V57M WP_002215394.1
        pubmed_reference: <empty> -> 16189114
    rpsJ_V57Q WP_002215394.1
        pubmed_reference: <empty> -> 16189114

Added families
    -                -                              Acr3 family arsenite efflux transporter
    aph(2'')         NF000076.3                     APH(2'')-Ie/IVa family aminoglycoside O-phosphotransferase
    arr              NF000066.1                     NAD(+)--rifampin ADP-ribosyltransferase
    arr              NF000318.1                     NAD(+)--rifampin ADP-ribosyltransferase Arr-2b
    arsN1            NF040503.1                     arsinothricin resistance N-acetyltransferase ArsN1 family A
    arsN1            NF040504.1                     arsinothricin resistance N-acetyltransferase ArsN1 family B
    arsN2            NF040501.1                     arsenic resistance N-acetyltransferase ArsN2
    arsN             -                              ArsN family N-acetyltransferase
    becA             -                              ADP-ribosylating binary toxin enzymatic subunit BecA
    becB             -                              ADP-ribosylating binary toxin binding subunit BecB
    blaADC           -                              ADC-like cephalosporin-hydrolyzing class C beta-lactamase
    blaCTX-M         -                              CTX-M-151 family class A beta-lactamase
    blaI             -                              beta-lactamase repressor
    blaLRA10         -                              LRA10 family class C beta-lactamase
    blaLRA           -                              LRA12 family subclass B3 metallo-beta-lactamase
    blaLRA18         -                              LRA18 family class C beta-lactamase
    blaLRA           -                              LRA2 family subclass B3 metallo-beta-lactamase
    blaLRA           -                              LRA3 family subclass B3 metallo-beta-lactamase
    blaOXA           NF040529.1                     OXA-1036 family class D beta-lactamase
    blaOXA           NF000386.2                     OXA-10 family class D beta-lactamase
    blaOXA           NF033818.0                     OXA-114 family class D beta-lactamase
    blaOXA           NF033702.0                     OXA-12 family class D beta-lactamase
    blaOXA           NF000436.2                     OXA-134 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000464.2                     OXA-143 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000461.2                     OXA-184 family class D beta-lactamase
    blaOXA           NF000388.2                     OXA-1 family class D beta-lactamase
    blaOXA           NF000417.2                     OXA-211 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000269.2                     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000418.2                     OXA-214 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000501.2                     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033509.1                     OXA-22 family class D beta-lactamase
    blaOXA           NF000266.2                     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000434.2                     OXA-24 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033653.1                     OXA-266 family class D beta-lactamase
    blaOXA           NF033648.1                     OXA-274 family class D beta-lactamase
    blaOXA           NF000520.2                     OXA-286 family class D beta-lactamase
    blaOXA           NF038386.1                     OXA-294 family class D beta-lactamase
    blaOXA           NF000267.2                     OXA-2 family class D beta-lactamase
    blaOXA           NF033815.0                     OXA-364 family class D beta-lactamase
    blaOXA           NF000415.2                     OXA-372 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF038217.1                     OXA-427 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF040531.1                     OXA-42 family class D beta-lactamase
    blaOXA           NF033104.0                     OXA-46 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF000387.2                     OXA-48 family class D beta-lactamase
    blaOXA           NF000462.2                     OXA-493 family class D beta-lactamase
    blaOXA           NF000432.2                     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF000268.2                     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           -                              OXA-542 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF040530.1                     OXA-548 family class D beta-lactamase
    blaOXA           NF033667.1                     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033613.1                     OXA-576 family class D beta-lactamase
    blaOXA           NF000500.2                     OXA-58 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF040527.1                     OXA-5 family class D beta-lactamase
    blaOXA           NF000395.3                     OXA-60 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000435.2                     OXA-61 family class D beta-lactamase
    blaOXA           NF000430.2                     OXA-62 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000429.2                     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF038333.1                     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033666.1                     OXA-727 family class D beta-lactamase
    blaOXA           NF000502.2                     OXA-85 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF038183.1                     OXA-919 family class D beta-lactamase
    blaOXA           NF040532.1                     OXA-9 family class D beta-lactamase
    blaOXA           NF000463.2                     class D beta-lactamase
    blaRAA           NF040467.1                     RAA family extended-spectrum beta-lactamase
    blaRSA1          -                              RSA1 family class A beta-lactamase
    ble              NF000028.1                     BLMA family bleomycin binding protein
    cdtB             -                              cytolethal distending toxin S-CDT
    copA             -                              copper-translocating P-type ATPase CopA
    copB             -                              copper/silver-translocating P-type ATPase CopB
    cpa              -                              alpha-toxin
    cpb              -                              beta-channel forming cytolysin CPB
    cpb2             -                              beta-2 toxin CPB2
    cpd              -                              beta-channel forming cytolysin CPD
    cpe              -                              enterotoxin CPE
    etx              -                              epsilon toxin type B
    fos              -                              FosG/FosC2-related fosfomycin resistance glutathione transferase
    fosA             NF040540.1                     FosA5 family fosfomycin resistance glutathione transferase
    fosB             NF000098.1                     FosB family fosfomycin resistance bacillithiol transferase
    fosB             NF000063.1                     FosB family fosfomycin resistance bacillithiol transferase
    iap              -                              ADP-ribosylating binary toxin iota enzymatic subunit Ia
    ibp              -                              ADP-ribosylating binary toxin iota binding subunit Ib
    merB1            -                              organomercurial lyase MerB1
    mtrA             -                              efflux transporter MtrCDE transcriptional activator MtrA
    netB             -                              necrotizing enteritis toxin NetB
    netF             -                              necrotizing enteritis toxin NetF
    pfoA             -                              cholesterol-dependent cytolysin perfringolysin O
    satA             -                              streptothricin N-acetyltransferase SatA
    satA             -                              streptothricin N-acetyltransferase SatA
    tpeL             -                              glycosylating toxin TpeL
    vanA-Ao2         NF000092.1                     D-alanine--(R)-lactate ligase VanA-Ao2
    vanT             NF033131.1                     VanT-G-like membrane-bound serine racemase
    vanXY            NF000149.1                     D-Ala-D-Ala dipeptidase/D-Ala-D-Ala carboxypeptidase VanXY-G
    vanY-N           NF000086.1                     D,D-peptidase/D,D-carboxypeptidase VanY-N
Removed families
    ble              NF000028.1                     BLMA family bleomycin binding protein
    cdtB             -                              cytolethal distending toxin S-CDT
    aac(6')-I        -                              AAC(6')-Ighjkrstuvwx family aminoglycoside N-acetyltransferase
    aac(6')          -                              AAC(6')-Ia family aminoglycoside 6'-N-acetyltransferase
    aadA1a           -                              ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA1a
    aadA2ah          -                              ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA2ah
    aadA2bc          -                              ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA2bc
    aph(2'')         NF000076.3                     APH(2'')-Ie/IVa family aminoglycoside O-phosphotransferase
    arr              NF000066.1                     NAD(+)--rifampin ADP-ribosyltransferase
    arr              NF000318.1                     NAD(+)--rifampin ADP-ribosyltransferase
    blaI             -                              beta-lactamase repressor
    blaADC           -                              ADC-like cephalosporin-hydrolyzing class C beta-lactamase
    blaCTX-M         -                              CTX-M-151 family class A beta-lactamase
    blaLRA10         -                              LRA10 family class C beta-lactamase
    blaLRA           -                              LRA12 family subclass B3 metallo-beta-lactamase
    blaLRA18         -                              LRA18 family class C beta-lactamase
    blaLRA           -                              LRA2 family subclass B3 metallo-beta-lactamase
    blaLRA           -                              LRA3 family subclass B3 metallo-beta-lactamase
    blaOXA           NF000386.2                     OXA-10 family class D beta-lactamase
    blaOXA           NF033818.0                     OXA-114 family class D beta-lactamase
    blaOXA           NF033702.0                     OXA-12 family class D beta-lactamase
    blaOXA           NF000436.2                     OXA-134 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000464.2                     OXA-143 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000461.2                     OXA-184 family class D beta-lactamase
    blaOXA           NF000388.2                     OXA-1 family class D beta-lactamase
    blaOXA           NF000417.2                     OXA-211 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000269.2                     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000418.2                     OXA-214 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000501.2                     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033509.1                     OXA-22 family class D beta-lactamase
    blaOXA           NF000266.2                     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000434.2                     OXA-24 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033653.1                     OXA-266 family class D beta-lactamase
    blaOXA           NF033648.1                     OXA-274 family class D beta-lactamase
    blaOXA           NF000520.2                     OXA-286 family class D beta-lactamase
    blaOXA           NF038386.1                     OXA-294 family class D beta-lactamase
    blaOXA           NF000267.2                     OXA-2 family class D beta-lactamase
    blaOXA           NF033815.0                     OXA-364 family class D beta-lactamase
    blaOXA           NF000415.2                     OXA-372 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF038217.1                     OXA-427 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033104.0                     OXA-46 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF000387.2                     OXA-48 family class D beta-lactamase
    blaOXA           NF000462.2                     OXA-493 family class D beta-lactamase
    blaOXA           NF000432.2                     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF000268.2                     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           -                              OXA-542 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           -                              OXA-548 family class D beta-lactamase
    blaOXA           NF033667.1                     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033613.1                     OXA-576 family class D beta-lactamase
    blaOXA           NF000500.2                     OXA-58 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           -                              OXA-5 family class D beta-lactamase
    blaOXA           NF000395.3                     OXA-60 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000435.2                     OXA-61 family class D beta-lactamase
    blaOXA           NF000430.2                     OXA-62 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF000429.2                     OXA-63 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF038333.1                     blaOXA-679 family carbapenem-hydrolyzing class D beta-lactamase
    blaOXA           NF033666.1                     OXA-727 family class D beta-lactamase
    blaOXA           NF000502.2                     OXA-85 family oxacillin-hydrolyzing class D beta-lactamase
    blaOXA           NF038183.1                     OXA-919 family class D beta-lactamase
    blaOXA           NF000463.2                     class D beta-lactamase
    catB8            -                              type B-3 chloramphenicol O-acetyltransferase CatB8j
    catB8k           -                              type B-3 chloramphenicol O-acetyltransferase CatB8k
    copA             -                              copper-translocating P-type ATPase CopA
    copB             -                              copper/silver-translocating P-type ATPase CopB
    fos              NF000124.1                     FosG/FosC2 family fosfomycin resistance glutathione transferase
    fosB             NF000063.1                     FosB family fosfomycin resistance bacillithiol transferase
    fosB             NF000098.1                     FosB family fosfomycin resistance bacillithiol transferase
    fos              NF033405.1                     fosfomycin resistance glutathione transferase FosLL
    mtrA             -                              efflux transporter MtrCDE transcriptional activator MtrA
    sat2e            -                              streptothricin N-acetyltransferase Sat2e
    satA             -                              streptothricin N-acetyltransferase SatA
    satA             -                              streptothricin N-acetyltransferase SatA
    vanAo2           NF000092.1                     D-alanine--(R)-lactate ligase VanA-Ao2
    vanT             NF033131.1                     VanT-G-like membrane-bound serine racemase
    vanXY            NF000149.1                     D-Ala-D-Ala dipeptidase/D-Ala-D-Ala carboxypeptidase VanXY-G
    vanY             NF000086.1                     VanY-like protein
Family changes
    -                TonB-dependent siderophore receptor
        gene_symbol:     sidero -> -
    -                DNA-binding response regulator
        gene_symbol:     response_reg -> -
    -                SPATE family serine protease autotransporter
        gene_symbol:     spate -> -
    blaCRP           CRP family carbapenem-hydrolyzing class A beta-lactamase
        hmm_id:          - -> NF040548.1
    blaLAQ           LAQ family class C beta-lactamase
        hmm_id:          - -> NF040478.1
    blaSFC           SFC family carbapenem-hydrolyzing class A beta-lactamase
        hmm_id:          - -> NF040547.1
    dfrE             trimethoprim-resistant dihydrofolate reductase DfrE
        hmm_id:          NF033473.1 -> NF040541.1
    dfr              DfrD/DfrG/DfrK family trimethoprim-resistant dihydrofolate reductase
        gene_symbol:     dfr_DGK -> dfr
    eat(A)           ABC-F type ribosomal protection-like protein Eat(A)
        family_name:     ABC-F type ribosomal protection protein Eat(A) -> ABC-F type ribosomal protection-like protein Eat(A)
    -                macrolide glycosyltransferase
        gene_symbol:     macro_glyco -> -
    mph              Mph(E)/Mph(G) family macrolide 2'-phosphotransferase
        gene_symbol:     mph_3 -> mph
    nim              NimABCDEF family nitroimidazole resistance protein
        gene_symbol:     nimABCDEF -> nim
    -                16S rRNA (adenine(1408)-N(1))-methyltransferase
        gene_symbol:     npmA_gen -> -
    qac              QacCGHJ group quaternary ammonium compound efflux SMR transporter
        gene_symbol:     qacCGHJ -> qac
    rgt              Rgt1438 family rifamycin-inactivating glycosyltransferase
        family_name:     rifamycin-inactivating glycosyltransferase Rgt -> Rgt1438 family rifamycin-inactivating glycosyltransferase
    -                bleomycin binding protein
        gene_symbol:     sequest -> -
    -                glycosylating toxin
        gene_symbol:     tcd_gen -> -
    tet              tetracycline efflux MFS transporter
        gene_symbol:     tet_MFS_efflux -> tet
    tet              tetracycline resistance ribosomal protection protein
        gene_symbol:     tet_rib_protect -> tet


----------------------------------------------------------------------
Changes included in 2021-08-11.1
----------------------------------------------------------------------

Overview:
- Refinement of resistance information for many alleles in Product name and
  Subclass fields, particularly in blaSHV and tet families
- Several new HMMs for smaller beta-lactamase families
- Many new beta-lactamase alleles
- Duplications in pubmed references were removed and new references added
- New Listeria metal resistance genes were added
- Point mutations in Neisseria and Pseudomonas aeruginosa were added
- blaACC-5 was removed becuase the only example we have is incomplete
- Some family IDs were changed, some nodes in the hierarchy without effect were
  removed, and some nodes were added
    - Note that these changes were made to standardize family ID, and improve
      the organization of families. The removed "families" should not cause the
      loss of any AMRFinderPlus hits, indeed, the new HMMs could identify some
      more distant homologs for those families that received them.


Summary:
   Total proteins: 6854
        Core proteins: 5880
        Plus proteins: 974
   AMR proteins: 5923
   STRESS proteins: 231
   VIRULENCE proteins: 700
   Point mutations: 852
   Point mutation references: 143
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Neisseria, Pseudomonas_aeruginosa, Salmonella,
       Staphylococcus_aureus, Staphylococcus_pseudintermedius, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 639

Updates since release 2021-06-01.1:
   Proteins added: 73
       Core proteins added: 52
       Plus proteins added: 21
   AMR proteins added: 53
   STRESS proteins added: 20
   Alleles added: 51
   Point mutations added: 107
   Proteins removed: 1
       Core proteins removed: 1
       Plus proteins removed: 0
   Reference Gene Catalog entries changed: 471
   Families added: 22
   Families removed: 7
   Families changed: 7

Added proteins
    core AMR AMR
        bcrA             NG_076629.1 WP_002389535.1     bacitracin resistance ABC transporter ATP-binding subunit BcrA
        blaACT-90        NG_076632.1 WP_023305291.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-90
        blaASU1-1        NG_076656.1 WP_219860711.1     class A beta-lactamase ASU1-1
        blaB3SU1-1       NG_076657.1 WP_219860712.1     subclass B3 metallo-beta-lactamase B3SU1-1
        blaB3SU2-1       NG_076658.1 WP_219860713.1     subclass B3 metallo-beta-lactamase B3SU2-1
        blaCMY-172       NG_076652.1 WP_215824899.1     class C beta-lactamase CMY-172
        blaGES-49        NG_076643.1 WP_219860707.1     carbapenem-hydrolyzing class A beta-lactamase GES-49
        blaIMP-86        NG_076650.1 WP_219860708.1     subclass B1 metallo-beta-lactamase IMP-86
        blaIMP-87        NG_076651.1 WP_219860709.1     subclass B1 metallo-beta-lactamase IMP-87
        blaIMP-91        NG_076634.1 WP_079387329.1     subclass B1 metallo-beta-lactamase IMP-91
        blaKPC-90        NG_076666.1 WP_219833567.1     carbapenem-hydrolyzing class A beta-lactamase KPC-90
        blaKPC-91        NG_076667.1 WP_219860720.1     carbapenem-hydrolyzing class A beta-lactamase KPC-91
        blaKPC-94        NG_076680.1 WP_219804981.1     class A beta-lactamase KPC-94
        blaKPC-95        NG_076681.1 WP_219795346.1     class A beta-lactamase KPC-95
        blaLAQ-1         NG_076677.1 WP_219860729.1     class C beta-lactamase LAQ-1
        blaNDM-34        NG_076661.1 WP_219860715.1     subclass B1 metallo-beta-lactamase NDM-34
        blaNDM-35        NG_076662.1 WP_219860716.1     subclass B1 metallo-beta-lactamase NDM-35
        blaNDM-36        NG_076641.1 WP_214140123.1     subclass B1 metallo-beta-lactamase NDM-36
        blaNDM-37        NG_076642.1 WP_214251060.1     subclass B1 metallo-beta-lactamase NDM-37
        blaNDM-38        NG_076664.1 WP_219860718.1     subclass B1 metallo-beta-lactamase NDM-38
        blaOXA-1013      NG_076673.1 WP_219860726.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-1013
        blaOXA-1014      NG_076674.1 WP_049291121.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-1014
        blaOXA-1015      NG_076675.1 WP_219860727.1     OXA-10 family class D beta-lactamase OXA-1015
        blaOXA-1016      NG_076676.1 WP_219860728.1     OXA-372 family carbapenem-hydrolyzing class D beta-lactamase OXA-1016
        blaOXA-1017      NG_076678.1 WP_219860730.1     OXA-2 family class D beta-lactamase OXA-1017
        blaOXA-957       NG_076659.1 WP_219860714.1     class D beta-lactamase OXA-957
        blaPAD-1         NG_076644.1 WP_068885073.1     carbapenem-hydrolyzing class A beta-lactamase PAD-1
        blaPAM-1         NG_076630.1 WP_043245728.1     subclass B3 metallo-beta-lactamase PAM-1
        blaPDC-484       NG_076668.1 WP_219860721.1     class C beta-lactamase PDC-484
        blaPDC-485       NG_076669.1 WP_219860722.1     class C beta-lactamase PDC-485
        blaPDC-486       NG_076670.1 WP_219860723.1     class C beta-lactamase PDC-486
        blaPDC-487       NG_076671.1 WP_219860724.1     class C beta-lactamase PDC-487
        blaPDC-488       NG_076672.1 WP_219860725.1     class C beta-lactamase PDC-488
        blaPLA-4         NG_076631.1 WP_032687534.1     class A beta-lactamase PLA-4
        blaPLA-5         NG_076637.1 WP_219860706.1     class A beta-lactamase PLA-5
        blaSFDC-1        NG_076654.1 WP_218519361.1     class C beta-lactamase SFDC-1
        blaTEM-239       NG_076645.1 WP_197098296.1     class A beta-lactamase TEM-239
        blaTEM-244       NG_076655.1 WP_219860710.1     class A beta-lactamase TEM-244
        blaVAM-1         NG_076653.1 WP_181726415.1     subclass B1 metallo-beta-lactamase VAM-1
        blaVEB-29        NG_076663.1 WP_219860717.1     class A extended-spectrum beta-lactamase VEB-29
        blaVEB-30        NG_076665.1 WP_219860719.1     class A extended-spectrum beta-lactamase VEB-30
        mcr-10.2         NG_076640.1 WP_208557566.1     phosphoethanolamine--lipid A transferase MCR-10.2
        mcr-10.3         NG_076639.1 WP_208584627.1     phosphoethanolamine--lipid A transferase MCR-10.3
        mcr-10.4         NG_076638.1 WP_208595319.1     phosphoethanolamine--lipid A transferase MCR-10.4
        mcr-2.8          NG_076679.1 WP_219860731.1     phosphoethanolamine--lipid A transferase MCR-2.8
        poxtA2           NG_076660.1 WP_209691075.1     ABC-F type ribosomal protection protein PoxtA2
        tmexC2           NG_076647.1 WP_088903431.1     multidrug efflux RND transporter periplasmic adaptor subunit TMexC2
        tmexC3           NG_076635.1 WP_034039546.1     multidrug efflux RND transporter periplasmic adaptor subunit TMexC3
        tmexD2           NG_076648.1 WP_027591160.1     multidrug efflux RND transporter permease subunit TMexD2
        tmexD3           NG_076636.1 WP_034065037.1     multidrug efflux RND transporter permease subunit TMexD3
        toprJ2           NG_076649.1 WP_088903432.1     multidrug efflux transporter outer membrane subunit TOprJ2
    core STRESS BIOCIDE
        qacH             NG_076646.1 WP_000121134.1     quaternary ammonium compound efflux SMR transporter QacH
    plus AMR AMR
        aph(3')-IId      MT975442.1 QQK39289.1          aminoglycoside O-phosphotransferase APH(3')-IId
        mcr-9.2          JAGFWX010000027.1 MBO4175406.1 phosphoethanolamine--lipid A transferase MCR-9.2
    plus STRESS METAL
        cadC             L28104.1 AAA25276.1            Cd(II)-sensing metalloregulatory transcriptional repressor CadC
        cadC             AP022822.1 BCA86950.1          Cd(II)-sensing metalloregulatory transcriptional repressor CadC
        cadA             AP022822.1 BCA86951.1          cadmium-translocating P-type ATPase CadA
        arsD2            CM001159.1 EGJ25779.1          arsenite efflux transporter metallochaperone ArsD-related protein
        arsA             CM001159.1 EGJ25780.1          arsenite efflux transporter ATPase subunit ArsA
        arsR             CM001159.1 EGJ25781.1          As(III)-sensing metalloregulatory transcriptional repressor ArsR
        arsD             CM001159.1 EGJ25782.1          arsenite efflux transporter metallochaperone ArsD
        arsR             CM001159.1 EGJ25783.1          As(III)-sensing metalloregulatory transcriptional repressor ArsR
        arsA             CM001159.1 EGJ25784.1          arsenite efflux transporter ATPase subunit ArsA
        arsB             CM001159.1 EGJ25785.1          arsenite efflux transporter membrane subunit ArsB
        arsB             CM001159.1 EGJ25786.1          arsenite efflux transporter membrane subunit ArsB
        cadC             CM001159.1 EGJ25791.1          Cd(II)-sensing metalloregulatory transcriptional repressor CadC
        cadA             CM001159.1 EGJ25792.1          cadmium-translocating P-type ATPase CadA
        arsB             ABAGVN010000004.1 EHL9033999.1 arsenite efflux transporter membrane subunit ArsB
        arsB             QDBI01000003.1 KAA9473339.1    arsenite efflux transporter membrane subunit ArsB
        arsD             QDBI01000003.1 KAA9473340.1    arsenite efflux transporter metallochaperone ArsD
        arsA             QDBI01000003.1 KAA9473341.1    arsenite efflux transporter ATPase subunit ArsA
        arsD             QDBI01000003.1 KAA9473342.1    arsenite efflux transporter metallochaperone ArsD
        arsR             QDBI01000003.1 KAA9473343.1    As(III)-sensing metalloregulatory transcriptional repressor ArsR
Added point mutations
    core AMR POINT
        16S_C1191T       SPECTINOMYCIN Neisseria
        23S_A2045G       AZITHROMYCIN Neisseria
        23S_A2057G       AZITHROMYCIN Neisseria
        23S_A2145G       AZITHROMYCIN Neisseria
        23S_C2597T       AZITHROMYCIN Neisseria
        ampD_H77Y        CEPHALOSPORIN Pseudomonas_aeruginosa
        ampD_T139M       CEPHALOSPORIN Pseudomonas_aeruginosa
        ampR_D135G       CEPHALOSPORIN Pseudomonas_aeruginosa
        ampR_G154R       CEPHALOSPORIN Pseudomonas_aeruginosa
        dacB_G437D       CEPHALOSPORIN Pseudomonas_aeruginosa
        dacB_T428P       CEPHALOSPORIN Pseudomonas_aeruginosa
        dacB_W459STOP    CEPHALOSPORIN Pseudomonas_aeruginosa
        folP_R228S       SULFONAMIDE Neisseria
        glpT_T211P       FOSFOMYCIN Pseudomonas_aeruginosa
        gyrA_D87G        QUINOLONE Pseudomonas_aeruginosa
        gyrA_D87H        QUINOLONE Pseudomonas_aeruginosa
        gyrA_D87N        QUINOLONE Pseudomonas_aeruginosa
        gyrA_D95A        QUINOLONE Neisseria
        gyrA_D95G        QUINOLONE Neisseria
        gyrA_D95N        QUINOLONE Neisseria
        gyrA_H80R        QUINOLONE Pseudomonas_aeruginosa
        gyrA_S91F        QUINOLONE Neisseria
        gyrA_T83I        QUINOLONE Pseudomonas_aeruginosa
        gyrB_D429N       ZOLIFLODACIN Neisseria
        gyrB_K450N       ZOLIFLODACIN Neisseria
        gyrB_K450T       ZOLIFLODACIN Neisseria
        macAB_G-48T      AZITHROMYCIN Neisseria
        mexB_V45L        BETA-LACTAM/QUINOLONE/TETRACYCLINE Pseudomonas_aeruginosa
        mexD_Q178R       AVIBACTAM Pseudomonas_aeruginosa
        mexD_S133G       AVIBACTAM Pseudomonas_aeruginosa
        mexZ_G195E       CEPHALOSPORIN Pseudomonas_aeruginosa
        mtrC_C-120T      AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria
        mtrR_A-53del     AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria
        mtrR_A-56C       BETA-LACTAM/TETRACYCLINE Neisseria
        mtrR_A39T        AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria
        mtrR_G-131A      AZITHROMYCIN/BETA-LACTAM/TETRACYCLINE Neisseria
        mtrR_G45D        AZITHROMYCIN/CEPHALOSPORIN/TETRACYCLINE Neisseria
        norM_A-7G        QUINOLONE Neisseria
        norM_C-104T      QUINOLONE Neisseria
        ompK35_E132K     CARBAPENEM Klebsiella
        ompK35_W230STOP  CARBAPENEM Klebsiella
        ompK36_D135DGD   CARBAPENEM Klebsiella
        ompK36_E78STOP   CARBAPENEM Klebsiella
        ompK36_T126STOP  CARBAPENEM Klebsiella
        ompK36_T136TDT   CARBAPENEM Klebsiella
        ompK36_T192del   CARBAPENEM Klebsiella
        ompK36_T261STOP  CARBAPENEM Klebsiella
        ompK36_T333N     CARBAPENEM Klebsiella
        ompK36_W125STOP  CARBAPENEM Klebsiella
        oprD_Q142STOP    CARBAPENEM Pseudomonas_aeruginosa
        oprD_W138STOP    CARBAPENEM Pseudomonas_aeruginosa
        parC_D86N        QUINOLONE Neisseria
        parC_E91G        QUINOLONE Neisseria
        parC_E91K        QUINOLONE Neisseria
        parC_S87I        QUINOLONE Neisseria
        parC_S87L        QUINOLONE Pseudomonas_aeruginosa
        parC_S87N        QUINOLONE Neisseria
        parC_S87R        QUINOLONE Neisseria
        parC_S88P        QUINOLONE Neisseria
        parE_A473V       QUINOLONE Pseudomonas_aeruginosa
        parE_G410V       QUINOLONE Neisseria
        parE_M437I       QUINOLONE Pseudomonas_aeruginosa
        penA_A311V       CEPHALOSPORIN Neisseria
        penA_A501AA      CEPHALOSPORIN Neisseria
        penA_A501P       CEPHALOSPORIN Neisseria
        penA_A501T       BETA-LACTAM Neisseria
        penA_A501V       CEPHALOSPORIN Neisseria
        penA_A510V       CEPHALOSPORIN Neisseria
        penA_A516G       CEPHALOSPORIN Neisseria
        penA_D346DD      BETA-LACTAM Neisseria
        penA_F504L       CEPHALOSPORIN Neisseria
        penA_G542S       CEPHALOSPORIN Neisseria
        penA_G545S       CEPHALOSPORIN Neisseria
        penA_I312M       CEPHALOSPORIN Neisseria
        penA_N512Y       CEPHALOSPORIN Neisseria
        penA_P551L       BETA-LACTAM Neisseria
        penA_P551S       BETA-LACTAM Neisseria
        penA_T483S       CEPHALOSPORIN Neisseria
        penA_V316P       CEPHALOSPORIN Neisseria
        penA_V316T       CEPHALOSPORIN Neisseria
        phoP_A110V       COLISTIN Pseudomonas_aeruginosa
        phoP_R117L       COLISTIN Pseudomonas_aeruginosa
        phoQ_K123Q       COLISTIN Pseudomonas_aeruginosa
        phoQ_V260G       COLISTIN Pseudomonas_aeruginosa
        ponA_L421P       BETA-LACTAM Neisseria
        porB1b_A121D     BETA-LACTAM Neisseria
        porB1b_A121H     BETA-LACTAM Neisseria
        porB1b_A121N     BETA-LACTAM Neisseria
        porB1b_A121P     BETA-LACTAM Neisseria
        porB1b_G120D     BETA-LACTAM Neisseria
        porB1b_G120K     BETA-LACTAM Neisseria
        porB1b_G120P     BETA-LACTAM Neisseria
        porB1b_G120R     BETA-LACTAM Neisseria
        rplD_G70D        AZITHROMYCIN Neisseria
        rplV_K83KKGPSLK  AZITHROMYCIN Neisseria
        rplV_K90KARAK    AZITHROMYCIN Neisseria
        rpoB_G158V       CEPHALOSPORIN Neisseria
        rpoB_P157L       CEPHALOSPORIN Neisseria
        rpoB_R201H       CEPHALOSPORIN Neisseria
        rpoD_DDDA92del   CEPHALOSPORIN Neisseria
        rpoD_E98K        CEPHALOSPORIN Neisseria
        rpsE_K28E        SPECTINOMYCIN Neisseria
        rpsE_T24P        SPECTINOMYCIN Neisseria
        rpsE_V27del      SPECTINOMYCIN Neisseria
        rpsJ_V57L        TETRACYCLINE Neisseria
        rpsJ_V57M        TETRACYCLINE Neisseria
        rpsJ_V57Q        TETRACYCLINE Neisseria
Removed proteins
    core AMR AMR
        blaACC-5         NG_048595.1 WP_063857715.1     cephalosporin-hydrolyzing class C beta-lactamase ACC-5
Changed reference gene catalog records
    lin WP_010989615.1
        product_name:    lincomycin resistance ABC-F type ribosomal protection protein -> lmo0919 family lincomycin resistance ABC-F type ribosomal protection protein
    tet(X3) WP_015060917.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    tet(X3) WP_024160783.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    tet(X5) WP_063856444.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    tet(X4) WP_094309310.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    tet(X5) WP_150378267.1
        subclass:        TETRACYCLINE -> TIGECYCLINE
    blaACC-2 WP_063857702.1
        pubmed_reference: 10817695,10817695 -> 10817695
    blaACT-1 WP_063857727.1
        pubmed_reference: 9055993,9055993 -> 9055993
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        pubmed_reference: 19721065,20482453 -> 19721065, 20482453
    blaOXA-142 WP_063861041.1
        pubmed_reference: 19721065,20482453 -> 19721065, 20482453
    blaOXA-145 WP_063861043.1
        pubmed_reference: 19721065,21665906 -> 19721065, 21665906
    blaOXA-147 WP_063861045.1
        pubmed_reference: 20008045,20008045 -> 20008045
    blaOXA-15 WP_063861048.1
        pubmed_reference: 9087490,9087490 -> 9087490
    blaOXA-161 WP_063861101.1
        pubmed_reference: 19770278,19770278 -> 19770278
    blaOXA-17 WP_032491804.1
        pubmed_reference: 10348753,10348753 -> 10348753
    blaOXA-19 WP_063861309.1
        pubmed_reference: 9835500,9835500 -> 9835500
    blaOXA-226 WP_063861826.1
        pubmed_reference: 19933793,19933793 -> 19933793
    blaOXA-28 WP_032489753.1
        pubmed_reference: 11158739,11158739 -> 11158739
    blaOXA-295 WP_005260134.1
        product_name:    class D beta-lactamase OXA-295 -> OXA-294 family class D beta-lactamase OXA-295
    blaOXA-297 WP_005227858.1
        product_name:    class D beta-lactamase OXA-297 -> OXA-294 family class D beta-lactamase OXA-297
    blaOXA-298 WP_005282462.1
        product_name:    class D beta-lactamase OXA-298 -> OXA-294 family class D beta-lactamase OXA-298
    blaOXA-32 WP_063862613.1
        pubmed_reference: 11796380,11796380 -> 11796380
    blaOXA-35 WP_063862720.1
        pubmed_reference: 11679562,11679562 -> 11679562
    blaOXA-543 WP_058132644.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaOXA-544 WP_071537493.1
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaPDC-221 WP_100931731.1
        product_name:    class C beta-lactamase PDC-221 -> inhibitor-resistant class C beta-lactamase PDC-221
        pubmed_reference: <empty> -> 29149337
    blaPDC-222 WP_100931732.1
        product_name:    class C beta-lactamase PDC-222 -> inhibitor-resistant class C beta-lactamase PDC-222
        pubmed_reference: <empty> -> 29149337
    blaPDC-223 WP_100931733.1
        product_name:    class C beta-lactamase PDC-223 -> inhibitor-resistant class C beta-lactamase PDC-223
        pubmed_reference: <empty> -> 29149337
    blaPDC-335 WP_148044427.1
        product_name:    class C beta-lactamase PDC-335 -> inhibitor-resistant class C beta-lactamase PDC-335
        pubmed_reference: <empty> -> 30141088
    blaPDC-80 WP_058169253.1
        product_name:    class C beta-lactamase PDC-80 -> inhibitor-resistant class C beta-lactamase PDC-80
        pubmed_reference: 26248364 -> 26248364, 30141088
    blaPER-1 WP_001100753.1
        pubmed_reference: 8141562,8141562 -> 8141562
    blaPER-2 WP_032491907.1
        pubmed_reference: 8851581,8851581 -> 8851581
    blaPER-6 WP_063864595.1
        pubmed_reference: 20145085,20145085 -> 20145085
    blaPER-7 WP_032495440.1
        pubmed_reference: 21383087,21383087 -> 21383087
    blaSHV-1 WP_001620095.1
        pubmed_reference: 10582889,10582889 -> 10582889
    blaSHV-100 WP_063864604.1
        product_name:    class A beta-lactamase SHV-100 -> class A broad-spectrum beta-lactamase SHV-100
        pubmed_reference: 21415202,21415202 -> 21415202
    blaSHV-101 WP_063864605.1
        product_name:    class A beta-lactamase SHV-101 -> class A broad-spectrum beta-lactamase SHV-101
        pubmed_reference: 17804424,17804424 -> 17804424
    blaSHV-102 WP_063864606.1
        pubmed_reference: 18566158,18566158 -> 18566158
    blaSHV-103 WP_063864607.1
        product_name:    class A beta-lactamase SHV-103 -> class A broad-spectrum beta-lactamase SHV-103
        pubmed_reference: 18620848,18620848 -> 18620848
    blaSHV-104 WP_032492114.1
        product_name:    class A extended-spectrum beta-lactamase SHV-104 -> class A broad-spectrum beta-lactamase SHV-104
    blaSHV-105 WP_063864608.1
        pubmed_reference: 19075050,19075050 -> 19075050
    blaSHV-108 WP_063864611.1
        product_name:    class A beta-lactamase SHV-108 -> class A broad-spectrum beta-lactamase SHV-108
    blaSHV-109 WP_063864612.1
        pubmed_reference: 18725449,18725449 -> 18725449
    blaSHV-11 WP_004176269.1
        pubmed_reference: 9145849,9145849 -> 9145849
    blaSHV-111 WP_063864614.1
        pubmed_reference: 19343954,19343954 -> 19343954
    blaSHV-120 WP_063864616.1
        product_name:    class A beta-lactamase SHV-120 -> class A extended-spectrum beta-lactamase SHV-120
        pubmed_reference: <empty> -> 26409063
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaSHV-129 WP_032494802.1
        pubmed_reference: 22322349,22322349 -> 22322349
    blaSHV-13 WP_063864619.1
        pubmed_reference: 10722518,10722518 -> 10722518
    blaSHV-133 WP_063864621.1
        product_name:    class A beta-lactamase SHV-133 -> class A broad-spectrum beta-lactamase SHV-133
        pubmed_reference: 24475919 -> 24475919, 32284385
    blaSHV-135 WP_063864623.1
        product_name:    class A beta-lactamase SHV-135 -> class A broad-spectrum beta-lactamase SHV-135
    blaSHV-137 WP_063864624.1
        product_name:    class A beta-lactamase SHV-137 -> class A broad-spectrum beta-lactamase SHV-137
        pubmed_reference: <empty> -> 32284385
    blaSHV-14 WP_063864625.1
        pubmed_reference: 11120985,11120985 -> 11120985
    blaSHV-141 WP_063864626.1
        pubmed_reference: <empty> -> 25737290
    blaSHV-142 WP_063864627.1
        product_name:    class A beta-lactamase SHV-142 -> class A broad-spectrum beta-lactamase SHV-142
        pubmed_reference: 22537112,22537112 -> 22537112
    blaSHV-143 WP_063864628.1
        pubmed_reference: <empty> -> 25957381
    blaSHV-145 WP_063864630.1
        product_name:    class A beta-lactamase SHV-145 -> class A broad-spectrum beta-lactamase SHV-145
        pubmed_reference: <empty> -> 32284385
    blaSHV-147 WP_063864632.1
        product_name:    class A beta-lactamase SHV-147 -> class A broad-spectrum beta-lactamase SHV-147
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-148 WP_063864633.1
        product_name:    class A extended-spectrum beta-lactamase SHV-148 -> class A broad-spectrum beta-lactamase SHV-148
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-149 WP_063864634.1
        product_name:    class A beta-lactamase SHV-149 -> class A broad-spectrum beta-lactamase SHV-149
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-150 WP_063864636.1
        product_name:    class A beta-lactamase SHV-150 -> class A broad-spectrum beta-lactamase SHV-150
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-151 WP_063864637.1
        product_name:    class A beta-lactamase SHV-151 -> class A broad-spectrum beta-lactamase SHV-151
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-152 WP_063864638.1
        product_name:    class A beta-lactamase SHV-152 -> class A extended-spectrum beta-lactamase SHV-152
    blaSHV-153 WP_063864639.1
        product_name:    class A beta-lactamase SHV-153 -> class A extended-spectrum beta-lactamase SHV-153
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-154 WP_063864640.1
        product_name:    class A beta-lactamase SHV-154 -> class A extended-spectrum beta-lactamase SHV-154
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-155 WP_063864641.1
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-156 WP_063864642.1
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-157 WP_063864643.1
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-158 WP_063864644.1
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-159 WP_063864645.1
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-16 WP_063864646.1
        pubmed_reference: 11502518,11502518 -> 11502518
    blaSHV-160 WP_063864647.1
        product_name:    class A beta-lactamase SHV-160 -> class A extended-spectrum beta-lactamase SHV-160
        pubmed_reference: 23587957 -> 23587957, 32284385
    blaSHV-161 WP_063864648.1
        product_name:    class A beta-lactamase SHV-161 -> class A broad-spectrum beta-lactamase SHV-161
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-162 WP_063864649.1
        product_name:    class A beta-lactamase SHV-162 -> class A extended-spectrum beta-lactamase SHV-162
        pubmed_reference: 23587957 -> 23587957, 32284385
    blaSHV-163 WP_063864650.1
        product_name:    class A beta-lactamase SHV-163 -> class A extended-spectrum beta-lactamase SHV-163
        pubmed_reference: 23587957,23587957 -> 23587957
    blaSHV-165 WP_063864652.1
        product_name:    class A beta-lactamase SHV-165 -> class A extended-spectrum beta-lactamase SHV-165
        pubmed_reference: 23587957,23587957 -> 23587957, 32284385
    blaSHV-179 WP_063864657.1
        product_name:    class A beta-lactamase SHV-179 -> class A broad-spectrum beta-lactamase SHV-179
    blaSHV-18 WP_063864658.1
        pubmed_reference: 10952583,10952583 -> 10952583
    blaSHV-185 WP_063864662.1
        product_name:    class A beta-lactamase SHV-185 -> class A broad-spectrum beta-lactamase SHV-185
    blaSHV-187 WP_021440083.1
        product_name:    class A beta-lactamase SHV-187 -> class A broad-spectrum beta-lactamase SHV-187
    blaSHV-189 WP_063864665.1
        product_name:    class A beta-lactamase SHV-189 -> class A broad-spectrum beta-lactamase SHV-189
    blaSHV-24 WP_063864670.1
        pubmed_reference: 10817740,10817740 -> 10817740
    blaSHV-25 WP_063864671.1
        pubmed_reference: 11502506,11502506 -> 11502506
    blaSHV-26 WP_023280043.1
        pubmed_reference: 11502506,11502506 -> 11502506
    blaSHV-27 WP_023282555.1
        product_name:    class A extended-spectrum beta-lactamase SHV-27 -> class A broad-spectrum beta-lactamase SHV-27
        pubmed_reference: 11266422,11266422 -> 11266422, 16584302
    blaSHV-28 WP_004179754.1
        product_name:    class A beta-lactamase SHV-28 -> class A broad-spectrum beta-lactamase SHV-28
        pubmed_reference: 21359845,19172061 -> 19172061, 21359845
    blaSHV-29 WP_063864672.1
        product_name:    class A beta-lactamase SHV-29 -> class extended-spectrum A beta-lactamase SHV-29
        pubmed_reference: 11257029,11257029 -> 11257029, 32284385
    blaSHV-2A WP_032488413.1
        pubmed_reference: 1741919,10223953 -> 10223953, 1741919
    blaSHV-30 WP_032491180.1
        pubmed_reference: 16251316,16251316 -> 16251316
    blaSHV-31 WP_063864674.1
        pubmed_reference: 17178800,17178800 -> 17178800
    blaSHV-32 WP_063864675.1
        pubmed_reference: 11557480,11557480 -> 11557480
    blaSHV-33 WP_023325206.1
        pubmed_reference: 11557480,11557480 -> 11557480
    blaSHV-34 WP_063864676.1
        pubmed_reference: 14613945,14613945 -> 14613945
    blaSHV-36 WP_063864678.1
        product_name:    class A beta-lactamase SHV-36 -> class A broad-spectrum beta-lactamase SHV-36
        pubmed_reference: 17913717 -> 17913717, 32625176
    blaSHV-38 WP_063864680.1
        pubmed_reference: 12543688,12543688 -> 12543688
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaSHV-4 WP_152330890.1
        product_name:    class A beta-lactamase SHV-4 -> class A extended-spectrum beta-lactamase SHV-4
        pubmed_reference: 2694955,2694955 -> 2086215, 2694955, 7814497
    blaSHV-40 WP_063864681.1
        product_name:    class A extended-spectrum beta-lactamase SHV-40 -> class A broad-spectrum beta-lactamase SHV-40
        pubmed_reference: 15047521,15047521 -> 15047521, 16769193
    blaSHV-41 WP_063864682.1
        product_name:    class A extended-spectrum beta-lactamase SHV-41 -> class A broad-spectrum beta-lactamase SHV-41
        pubmed_reference: 15047521,15047521 -> 15047521, 16584302
    blaSHV-42 WP_063864683.1
        product_name:    class A extended-spectrum beta-lactamase SHV-42 -> class A broad-spectrum beta-lactamase SHV-42
        pubmed_reference: 15047521,15047521 -> 15047521
    blaSHV-43 WP_032490193.1
        pubmed_reference: 12543694,12543694 -> 12543694
    blaSHV-44 WP_063864684.1
        pubmed_reference: 14576109,14576109 -> 14576109
    blaSHV-46 WP_063864686.1
        pubmed_reference: 14638498,14638498 -> 14638498
    blaSHV-48 WP_063864687.1
        pubmed_reference: 19075050,19075050 -> 19075050
    blaSHV-49 WP_063864688.1
        pubmed_reference: 15504885,15504885 -> 15504885
    blaSHV-5 WP_011117369.1
        pubmed_reference: 2088203,2088203 -> 2088203
    blaSHV-50 WP_063864689.1
        product_name:    class A beta-lactamase SHV-50 -> class A broad-spectrum beta-lactamase SHV-50
    blaSHV-51 WP_063864690.1
        product_name:    class A beta-lactamase SHV-51 -> class A broad-spectrum beta-lactamase SHV-51
        pubmed_reference: <empty> -> 34182896
    blaSHV-52 WP_063864691.1
        product_name:    class A beta-lactamase SHV-52 -> inhibitor-resistant class A broad-spectrum beta-lactamase SHV-52
        pubmed_reference: <empty> -> 2086215
    blaSHV-55 WP_063864692.1
        pubmed_reference: 16938422,16938422 -> 16938422
    blaSHV-56 WP_063864693.1
        pubmed_reference: 18663019,18663019 -> 18663019
    blaSHV-57 WP_032490632.1
        pubmed_reference: 15673739,15673739 -> 15673739
    blaSHV-59 WP_063864694.1
        product_name:    class A beta-lactamase SHV-59 -> class A broad-spectrum beta-lactamase SHV-59
    blaSHV-60 WP_004183952.1
        pubmed_reference: 19272757,19272757 -> 19272757
    blaSHV-61 WP_063864695.1
        pubmed_reference: 19272757,19272757 -> 19272757
    blaSHV-62 WP_063864696.1
        pubmed_reference: 19272757,19272757 -> 19272757
    blaSHV-63 WP_063864697.1
        product_name:    class A beta-lactamase SHV-63 -> class A broad-spectrum beta-lactamase SHV-63
    blaSHV-65 WP_063864699.1
        product_name:    class A beta-lactamase SHV-65 -> class A extended-spectrum beta-lactamase SHV-65
        pubmed_reference: 17288792 -> 17288792, 26029910
    blaSHV-7 WP_020316986.1
        pubmed_reference: 7785992,7785992 -> 7785992
    blaSHV-70 WP_032491403.1
        pubmed_reference: 16563703,16563703 -> 16563703
    blaSHV-72 WP_063864704.1
        pubmed_reference: 18316518,18316518 -> 18316518
    blaSHV-8 WP_063864710.1
        pubmed_reference: 9056008,9056008 -> 9056008
    blaSHV-85 WP_063864713.1
        pubmed_reference: 18347108,18347108 -> 18347108
    blaSHV-89 WP_032491601.1
        pubmed_reference: 18587684,18587684 -> 18587684
    blaSHV-9 WP_032488887.1
        product_name:    class A beta-lactamase SHV-9 -> class A extended-spectrum beta-lactamase SHV-9
    blaSHV-92 WP_032491784.1
        product_name:    class A beta-lactamase SHV-92 -> inhibitor-resistant class A broad-spectrum beta-lactamase SHV-92
        pubmed_reference: 18029415,18029415 -> 18029415, 25691639
    blaSHV-95 WP_063864717.1
        product_name:    class A beta-lactamase SHV-95 -> class A broad-spectrum beta-lactamase SHV-95
    blaSHV-97 WP_063864719.1
        product_name:    class A beta-lactamase SHV-97 -> class A extended-spectrum beta-lactamase SHV-97
        pubmed_reference: 21940649 -> 21940649, 32284385
    blaSHV-98 WP_063864720.1
        product_name:    class A extended-spectrum beta-lactamase SHV-98 -> class A broad-spectrum beta-lactamase SHV-98
        pubmed_reference: 21415202,21415202 -> 21415202
    blaSHV-99 WP_063864721.1
        product_name:    class A extended-spectrum beta-lactamase SHV-99 -> class A broad-spectrum beta-lactamase SHV-99
    blaSME-1 WP_063864724.1
        pubmed_reference: 8092824,8092824 -> 8092824
    blaSME-2 WP_063864725.1
        pubmed_reference: 11036019,11036019 -> 11036019
    blaSME-3 WP_063864726.1
        pubmed_reference: 17005839,17005839 -> 17005839
    blaTEM-102 WP_063864794.1
        pubmed_reference: 12878521,12878521 -> 12878521
    blaTEM-109 WP_063864799.1
        pubmed_reference: 16251281,16251281 -> 16251281
    blaTEM-112 WP_063864802.1
        pubmed_reference: 15282240,15282240 -> 15282240
    blaTEM-113 WP_063864803.1
        pubmed_reference: 15282240,15282240 -> 15282240
    blaTEM-114 WP_063864804.1
        pubmed_reference: 15282240,15282240 -> 15282240
    blaTEM-115 WP_063864805.1
        pubmed_reference: 15047521,15047521 -> 15047521
    blaTEM-120 WP_063864806.1
        pubmed_reference: 15047521,15047521 -> 15047521
    blaTEM-121 WP_063864807.1
        pubmed_reference: 15561821,15561821 -> 15561821
    blaTEM-122 WP_063864808.1
        pubmed_reference: 15105100,15105100 -> 15105100
    blaTEM-125 WP_063864811.1
        pubmed_reference: 16801418,16801418 -> 16801418
    blaTEM-126 WP_063864819.1
        pubmed_reference: 15282240,15282240 -> 15282240
    blaTEM-127 WP_032490959.1
        pubmed_reference: 15650379,15650379 -> 15650379
    blaTEM-128 WP_032490960.1
        pubmed_reference: 15650379,15650379 -> 15650379
    blaTEM-129 WP_063864833.1
        pubmed_reference: 15472005,15472005 -> 15472005
    blaTEM-131 WP_063864850.1
        pubmed_reference: 15504851,15504851 -> 15504851
    blaTEM-132 WP_032490956.1
        pubmed_reference: 15980402,15980402 -> 15980402
    blaTEM-133 WP_063864851.1
        pubmed_reference: 15855544,15855544 -> 15855544
    blaTEM-134 WP_063864852.1
        pubmed_reference: 15793140,15793140 -> 15793140
    blaTEM-136 WP_063864853.1
        pubmed_reference: 16531430,16531430 -> 16531430
    blaTEM-137 WP_063864854.1
        pubmed_reference: 17561568,17561568 -> 17561568
    blaTEM-138 WP_032491283.1
        pubmed_reference: 16940125,16940125 -> 16940125
    blaTEM-139 WP_032491449.1
        pubmed_reference: 17382521,17382521 -> 17382521
    blaTEM-141 WP_032491376.1
        pubmed_reference: 17881870,17881870 -> 17881870
    blaTEM-144 WP_021598056.1
        pubmed_reference: 16436745,16436745 -> 16436745
    blaTEM-149 WP_063864860.1
        pubmed_reference: 18160520,18160520 -> 18160520
    blaTEM-151 WP_063864862.1
        pubmed_reference: 17220412,17220412 -> 17220412
    blaTEM-152 WP_063864863.1
        pubmed_reference: 17220412,17220412 -> 17220412
    blaTEM-153 WP_063864864.1
        pubmed_reference: 23579192,23579192 -> 23579192
    blaTEM-154 WP_063864865.1
        pubmed_reference: 17913717,17913717 -> 17913717
    blaTEM-155 WP_063864866.1
        pubmed_reference: 19075050,19075050 -> 19075050
    blaTEM-158 WP_063864868.1
        pubmed_reference: 17709463,17709463 -> 17709463
    blaTEM-159 WP_063864869.1
        pubmed_reference: 18292096,18292096 -> 18292096
    blaTEM-160 WP_063864871.1
        pubmed_reference: 18292096,18292096 -> 18292096
    blaTEM-164 WP_032492113.1
        pubmed_reference: 19728777,19728777 -> 19728777
    blaTEM-168 WP_063864876.1
        pubmed_reference: 19687235,19687235 -> 19687235
    blaTEM-17 WP_063864877.1
        pubmed_reference: 10681352,10681352 -> 10681352
    blaTEM-177 WP_063864878.1
        pubmed_reference: 23210906,23210906 -> 23210906
    blaTEM-178 WP_063864879.1
        pubmed_reference: 9371336,9371336 -> 9371336
    blaTEM-181 WP_000027060.1
        pubmed_reference: 21947397,21947397 -> 21947397
    blaTEM-182 WP_063864880.1
        pubmed_reference: 23335113,23335113 -> 23335113
    blaTEM-186 WP_063864884.1
        pubmed_reference: 22397509,22397509 -> 22397509
    blaTEM-187 WP_032494853.1
        pubmed_reference: 23478954,23478954 -> 23478954
    blaTEM-19 WP_033560332.1
        pubmed_reference: 2073111,2073111 -> 2073111
    blaTEM-191 WP_077064889.1
        product_name:    class A beta-lactamase TEM-191 -> class A extended-spectrum beta-lactamase TEM-191
        pubmed_reference: 22718774 -> 22718774, 26409063
        subclass:        BETA-LACTAM -> CEPHALOSPORIN
    blaTEM-26 WP_047028173.1
        pubmed_reference: 1416892,1416892 -> 1416892
    blaTEM-28 WP_063864909.1
        pubmed_reference: 8787920,8787920 -> 8787920
    blaTEM-29 WP_032490103.1
        pubmed_reference: 8586268,8586268 -> 8586268
    blaTEM-34 WP_015379489.1
        pubmed_reference: 8067742,8067742 -> 8067742
    blaTEM-40 WP_021526512.1
        pubmed_reference: 8585729,8585729 -> 8585729
    blaTEM-43 WP_063864912.1
        pubmed_reference: 9661002,9661002 -> 9661002
    blaTEM-45 WP_063864913.1
        pubmed_reference: 9021194,9021194 -> 9021194
    blaTEM-47 WP_063864914.1
        pubmed_reference: 9517925,9517925 -> 9517925
    blaTEM-48 WP_063864915.1
        pubmed_reference: 9517925,9517925 -> 9517925
    blaTEM-49 WP_063864916.1
        pubmed_reference: 9517925,9517925 -> 9517925
    blaTEM-52 WP_015058977.1
        pubmed_reference: 9449269,9449269 -> 9449269
    blaTEM-53 WP_063864923.1
        pubmed_reference: 9925535,9925535 -> 9925535
    blaTEM-54 WP_063864930.1
        pubmed_reference: 9925535,9925535 -> 9925535
    blaTEM-57 WP_032492330.1
        pubmed_reference: 10543745,10543745 -> 10543745
    blaTEM-6 WP_063864949.1
        pubmed_reference: 3312022,3312022 -> 3312022
    blaTEM-60 WP_032489150.1
        pubmed_reference: 9624494,9624494 -> 9624494
    blaTEM-63 WP_055314004.1
        pubmed_reference: 11120950,11120950 -> 11120950
    blaTEM-67 WP_032490504.1
        pubmed_reference: 12499163,12499163 -> 12499163
    blaTEM-71 WP_032490155.1
        pubmed_reference: 12019125,12019125 -> 12019125
    blaTEM-72 WP_032489614.1
        pubmed_reference: 10952610,10952610 -> 10952610
    blaTEM-76 WP_063864990.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-77 WP_063864996.1
        pubmed_reference: 10991849,10543745 -> 10543745, 10991849
    blaTEM-78 WP_063865003.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-79 WP_063865008.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-80 WP_063865024.1
        pubmed_reference: 11959543,11959543 -> 11959543
    blaTEM-81 WP_063865030.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-82 WP_063865036.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-83 WP_063865043.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-84 WP_063865053.1
        pubmed_reference: 10991849,10991849 -> 10991849
    blaTEM-85 WP_032490101.1
        pubmed_reference: 15855509,15855509 -> 15855509
    blaTEM-86 WP_032490102.1
        pubmed_reference: 15855509,15855509 -> 15855509
    blaTEM-87 WP_032489893.1
        pubmed_reference: 11850290,11850290 -> 11850290
    blaTEM-88 WP_032489980.1
        pubmed_reference: 11709362,11709362 -> 11709362
    blaTEM-90 WP_032490026.1
        pubmed_reference: 11557499,11557499 -> 11557499
    blaTEM-91 WP_063865088.1
        pubmed_reference: 12937007,12937007 -> 12937007
    blaTEM-93 WP_032490317.1
        pubmed_reference: 15855509,15855509 -> 15855509
    blaTEM-94 WP_032490318.1
        pubmed_reference: 15855509,15855509 -> 15855509
    blaTEM-95 WP_061659705.1
        pubmed_reference: 12234838,12234838 -> 12234838
    blaVEB-2 WP_063865158.1
        pubmed_reference: 11807680,11807680 -> 11807680
    blaVEB-3 WP_020956917.1
        pubmed_reference: 15695687,15695687 -> 15695687
    blaVEB-4 WP_063865159.1
        pubmed_reference: 18292096,18292096 -> 18292096
    blaVEB-6 WP_063865161.1
        pubmed_reference: 18025117,18025117 -> 18025117
    blaVIM-1 WP_013263789.1
        pubmed_reference: 10390207,18804966 -> 10390207, 18804966
    blaVIM-11 WP_034080264.1
        pubmed_reference: 15616342,15616342 -> 15616342
    blaVIM-12 WP_063865167.1
        pubmed_reference: 16304191,16304191 -> 16304191
    blaVIM-13 WP_063865168.1
        pubmed_reference: 18644957,18644957 -> 18644957
    blaVIM-14 WP_063865169.1
        pubmed_reference: 21521413,21521413 -> 21521413
    blaVIM-15 WP_063865170.1
        pubmed_reference: 18519714,18519714 -> 18519714
    blaVIM-16 WP_063865171.1
        pubmed_reference: 18519714,18519714 -> 18519714
    blaVIM-17 WP_023442721.1
        pubmed_reference: 19164147,19164147 -> 19164147
    blaVIM-18 WP_063865172.1
        pubmed_reference: 19164147,19114677 -> 19114677, 19164147
    blaVIM-19 WP_032492472.1
        pubmed_reference: 19917750,19917750 -> 19917750
    blaVIM-2 WP_003108247.1
        pubmed_reference: 10722487,18804966 -> 10722487, 18804966
    blaVIM-23 WP_063865174.1
        pubmed_reference: 20961909,20961909 -> 20961909
    blaVIM-24 WP_063865175.1
        pubmed_reference: 21282438,21282438 -> 21282438
    blaVIM-27 WP_032495187.1
        pubmed_reference: 21518835,21518835 -> 21518835
    blaVIM-3 WP_063865179.1
        pubmed_reference: 11451678,11451678 -> 11451678
    blaVIM-31 WP_063865181.1
        pubmed_reference: 22391550,22391550 -> 22391550
    blaVIM-33 WP_063865183.1
        pubmed_reference: 24185874,23070171 -> 23070171, 24185874
    blaVIM-34 WP_063865184.1
        pubmed_reference: 23934739,23934739 -> 23934739
    blaVIM-36 WP_063865186.1
        pubmed_reference: 24603963,24603963 -> 24603963
    blaVIM-37 WP_063865187.1
        pubmed_reference: 24603963,24603963 -> 24603963
    blaVIM-38 WP_063865188.1
        pubmed_reference: 24428980,24428980 -> 24428980
    blaVIM-4 WP_032492008.1
        pubmed_reference: 12435718,12435718 -> 12435718
    blaVIM-5 WP_032491390.1
        pubmed_reference: 15190017,15190017 -> 15190017
    blaVIM-6 WP_063865201.1
        pubmed_reference: 15155248,15155248 -> 15155248
    blaVIM-7 WP_011997479.1
        pubmed_reference: 23014719,14693560 -> 14693560, 23014719
    blaVIM-8 WP_063865202.1
        pubmed_reference: 15528701,15528701 -> 15528701
    ftsI_A515V WP_000227936.1
        product_name:    penicillin-binding protein PBP3 ftsI -> penicillin-binding protein PBP3 FtsI
    qnrE3 WP_010431379.1
        pubmed_reference: <empty> -> 34097486
    qnrE4 WP_047174394.1
        pubmed_reference: <empty> -> 34097486
    tmexC1 WP_118842626.1
        allele:          <empty> -> tmexC1
        gene_family:     tmexC1 -> tmexC
    tmexD1 WP_118842627.1
        allele:          <empty> -> tmexD1
        gene_family:     tmexD1 -> tmexD
    toprJ1 WP_003152694.1
        allele:          <empty> -> toprJ1
        gene_family:     toprJ1 -> toprJ

Added families
    aph(3')-IId      -                              aminoglycoside O-phosphotransferase APH(3')-IId
    arsB             -                              arsenite efflux transporter membrane subunit ArsB
    arsD2            -                              arsenite efflux transporter metallochaperone ArsD-related protein
    arsR             -                              As(III)-sensing metalloregulatory transcriptional repressor ArsR
    arsR             -                              As(III)-sensing metalloregulatory transcriptional repressor ArsR
    arsR             -                              As(III)-sensing metalloregulatory transcriptional repressor ArsR
    bcrA             -                              bacitracin resistance ABC transporter ATP-binding subunit BcrA
    blaASU1          -                              ASU1 family class A beta-lactamase
    blaB3SU1         -                              B3SU1 family subclass B3 metallo-beta-lactamase
    blaB3SU2         -                              B3SU2 family subclass B3 metallo-beta-lactamase
    blaLAQ           -                              LAQ family class C beta-lactamase
    blaOXA           NF038386.1                     OXA-294 family class D beta-lactamase
    blaPAD           NF040472.1                     PAD family carbapenem-hydrolyzing class A beta-lactamase
    blaPAM           -                              PAM family subclass B3 metallo-beta-lactamase
    blaSFDC          -                              SFDC family class C beta-lactamase
    blaVAM           -                              VAM family subclass B1 metallo-beta-lactamase
    cadA             -                              cadmium-translocating P-type ATPase CadA
    cadC             -                              Cd(II)-sensing metalloregulatory transcriptional repressor CadC
    qacH             -                              quaternary ammonium compound efflux SMR transporter QacH
    tmexC            -                              multidrug efflux RND transporter periplasmic adaptor subunit TMexC
    tmexD            -                              multidrug efflux RND transporter permease subunit TMexD
    toprJ            -                              multidrug efflux transporter outer membrane subunit TOprJ
Removed families
    cpt              -                              chloramphenicol phosphotransferase CPT family protein
    mexC             -                              MexC family multidrug efflux RND transporter periplasmic adaptor subunit
    mexD             -                              multidrug efflux RND transporter permease subunit MexD
    oprJ             -                              multidrug efflux transporter outer membrane subunit OprJ
    tmexC1           -                              multidrug efflux RND transporter periplasmic adaptor subunit TMexC1
    tmexD1           -                              multidrug efflux RND transporter permease subunit TMexD1
    toprJ1           -                              multidrug efflux transporter outer membrane subunit TOprJ1
Family changes
    blaEAM           EAM family subclass B3 metallo-beta-lactamase
        hmm_id:          - -> NF040470.1
    blaECM           ECM family subclass B3 metallo-beta-lactamase
        hmm_id:          - -> NF040468.1
    blaEFM           EFM family subclass B3 metallo-beta-lactamase
        hmm_id:          - -> NF040469.1
    blaORN           ORN family class A beta-lactamase
        hmm_id:          - -> NF038401.1
    blaPLA           PLA family class A beta-lactamase
        hmm_id:          - -> NF038398.1
    bla              PLA/ORN/TER family class A beta-lactamase
        gene_symbol:     blaPLA -> bla
    blaTER           TER family class A beta-lactamase
        hmm_id:          - -> NF038400.1

----------------------------------------------------------------------
Changes included in 2021-06-01.1
----------------------------------------------------------------------

Overview:

- This update includes a new "Synonyms" column in the Reference Gene Catalog
  populated with alternative gene symbols that may sometimes have been used to
  refer to the same gene.
- Many Klebsiella virulence genes added
- Toxin genes from Staph aureus added
- Tigecycline resistance genes and mutations in Klebsiella added
- CLASS/SUBCLASS added for some metal-resistance genes previously missing them
- A couple of refinements of subclass and scope based on functional evidence
- New HMM for DfrA12/DfrA21 family proteins
- Changes made to disambiguate the two uses of blaNDM-16
- NCBI is now curating alleles for CfiA
- The usual addition of new alleles submitted to NCBI

Statement about nomenclature decisions for CfiA:

NCBI has added CfiA (also known as CcrA) to the set of beta-lactamase families
for which we will provide advice and a reservation system for allele
assignments, linked to sequence submission to GenBank, and provide annotation
that we consider official. This follows our consultation with several community
experts in that family. Our coverage should help codify the resolution to some
past collisions and conflicts in names of cfiA alleles. The nomenclature we are
settling on mostly follows Litterio, et al. (PMID:29017951, 2017, with senior
author Marcela Radice), but with a few exceptions, as follows:

The first allele described, first named cfiA (cefoxitin and imipenem) in 1990
and then ccrA (carbapenem- and cephamycin resistance) later that same year,
will remain cfiA, for best continuity with a large literature, rather than
cfiA13 as proposed in PMID:29017951. The allele that has been called cfiA1,
cfiA2, cfiA3, and cfiA6 will remain cfiA2 in our Reference Gene Catalog, as in
past releases, to avoid the possibly incorrect assumption that the sequence
represented is the founding member of the family. We will continue to recognize
AAR04097.1 as cfiA11, following PMID:20226324 (2010), rather than renaming to
cfiA20 as suggested in PMID:29017951 (2017).

Statement about nomenclature decisions for blaNDM-16:

We noticed recently two different usages of the allele assignment blaNDM-16.
The more common allele was discussed critically in two articles, PMID:30147347
and PMID:29909397, one of which characterized the contributions of individual
residue changes to zinc affinity and thermostability. The other assignment was
official, as part of the beta-lactamase allele number reservation system run
previously at Lahey Clinic and now at NCBI. After review of the literature and
consultation with recent submitters, we have chosen to update the allele
assignments for these two proteins. The original Lahey-assigned NDM-16
(AKZ20823.1 and all identical proteins) is now NDM-16a, while BCO01847.1 (and
all identical proteins) is now NDM-16b, with NDM-32 as a synonym. This handling
is intended to protect links to discussions in the literature without
misleading on which protein is meant.


Summary:
   Total proteins: 6782
        Core proteins: 5829
        Plus proteins: 953
   AMR proteins: 5871
   STRESS proteins: 211
   VIRULENCE proteins: 700
   Point mutations: 745
   Point mutation references: 108
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius,
       Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 631

Updates since release 2021-03-01.1:
   Proteins added: 132
       Core proteins added: 70
       Plus proteins added: 62
   AMR proteins added: 71
   VIRULENCE proteins added: 61
   Alleles added: 66
   Point mutations added: 17
   Proteins removed: 0
   Reference Gene Catalog entries changed: 39
   Families added: 67
   Families removed: 0
   Families changed: 1

Added proteins
    core AMR AMR
        toprJ1           NG_074694.1 WP_003152694.1     multidrug efflux transporter outer membrane subunit TOprJ1
        mef(F)           NG_074691.1 WP_101035418.1     macrolide efflux MFS transporter Mef(F)
        tmexC1           NG_074692.1 WP_118842626.1     multidrug efflux RND transporter periplasmic adaptor subunit TMexC1
        tmexD1           NG_074693.1 WP_118842627.1     multidrug efflux RND transporter permease subunit TMexD1
        blaACT-88        NG_074695.1 WP_181240047.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-88
        blaACT-89        NG_074696.1 WP_049134845.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-89
        blaAFM-3         NG_074697.1 WP_211862582.1     subclass B1 metallo-beta-lactamase AFM-3
        blaAXC-6         NG_074698.1 WP_213994577.1     carbapenem-hydrolyzing class A beta-lactamase AXC-6
        blaCARB-56       NG_074699.1 WP_017821520.1     carbenicillin-hydrolyzing class A beta-lactamase CARB-56
        blaCARB-57       NG_074700.1 WP_005391263.1     carbenicillin-hydrolyzing class A beta-lactamase CARB-57
        blaCMY-175       NG_074701.1 WP_213994578.1     class C beta-lactamase CMY-175
        blaCMY-176       NG_074702.1 WP_213994579.1     class C beta-lactamase CMY-176
        blaCTX-M-243     NG_074703.1 WP_213994580.1     class A extended-spectrum beta-lactamase CTX-M-243
        blaCTX-M-245     NG_074704.1 WP_213994581.1     class A extended-spectrum beta-lactamase CTX-M-245
        blaCTX-M-246     NG_074705.1 WP_213994582.1     class A extended-spectrum beta-lactamase CTX-M-246
        blaFOX-18        NG_074706.1 WP_213994583.1     cephalosporin-hydrolyzing class C beta-lactamase FOX-18
        blaFOX-19        NG_074707.1 WP_213994584.1     cephalosporin-hydrolyzing class C beta-lactamase FOX-19
        blaGES-47        NG_074708.1 WP_213994585.1     carbapenem-hydrolyzing class A beta-lactamase GES-47
        blaGES-48        NG_074709.1 WP_213994586.1     carbapenem-hydrolyzing class A beta-lactamase GES-48
        blaGOB-3         NG_074710.1 WP_078411523.1     subclass B3 metallo-beta-lactamase GOB-3
        blaGOB-4         NG_074711.1 WP_078691374.1     subclass B3 metallo-beta-lactamase GOB-4
        blaGOB-6         NG_074712.1 WP_069147617.1     subclass B3 metallo-beta-lactamase GOB-6
        blaIMP-90        NG_074713.1 WP_213994587.1     subclass B1 metallo-beta-lactamase IMP-90
        blaKPC-47        NG_074714.1 WP_213994588.1     carbapenem-hydrolyzing class A beta-lactamase KPC-47
        blaKPC-48        NG_074715.1 WP_213994589.1     carbapenem-hydrolyzing class A beta-lactamase KPC-48
        blaKPC-67        NG_074716.1 WP_210204487.1     class A beta-lactamase KPC-67
        blaKPC-68        NG_074717.1 WP_210204468.1     class A beta-lactamase KPC-68
        blaKPC-69        NG_074718.1 WP_210205486.1     class A beta-lactamase KPC-69
        blaKPC-70        NG_074719.1 WP_210205477.1     class A beta-lactamase KPC-70
        blaKPC-84        NG_074720.1 WP_213994590.1     carbapenem-hydrolyzing class A beta-lactamase KPC-84
        blaKPC-85        NG_074721.1 WP_213994591.1     carbapenem-hydrolyzing class A beta-lactamase KPC-85
        blaKPC-86        NG_074722.1 WP_213994592.1     carbapenem-hydrolyzing class A beta-lactamase KPC-86
        blaKPC-87        NG_074723.1 WP_213994593.1     carbapenem-hydrolyzing class A beta-lactamase KPC-87
        blaKPC-88        NG_074724.1 WP_213994594.1     carbapenem-hydrolyzing class A beta-lactamase KPC-88
        blaMOX-15        NG_074725.1 WP_103261726.1     CMY-1/MOX family class C beta-lactamase MOX-15
        blaNDM-16b       NG_074726.1 WP_133963898.1     subclass B1 metallo-beta-lactamase NDM-16b
        blaOXA-790       NG_074727.1 WP_213994595.1     OXA-114 family class D beta-lactamase OXA-790
        blaOXA-791       NG_074728.1 WP_213994596.1     OXA-114 family class D beta-lactamase OXA-791
        blaOXA-950       NG_074729.1 WP_029305121.1     OXA-12 family class D beta-lactamase OXA-950
        blaOXA-951       NG_074730.1 WP_213994597.1     OXA-12 family class D beta-lactamase OXA-951
        blaOXA-952       NG_074731.1 WP_213994598.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-952
        blaOXA-953       NG_074732.1 WP_049044515.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-953
        blaOXA-954       NG_074733.1 WP_213994599.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-954
        blaOXA-955       NG_074734.1 WP_213994600.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-955
        blaOXA-956       NG_074735.1 WP_021139936.1     class D beta-lactamase OXA-956
        blaOXA-958       NG_074736.1 WP_058052637.1     OXA-12 family class D beta-lactamase OXA-958
        blaOXA-959       NG_074737.1 WP_075112279.1     OXA-12 family class D beta-lactamase OXA-959
        blaOXA-960       NG_074738.1 WP_213994601.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-960
        blaOXA-961       NG_074739.1 WP_213994602.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-961
        blaOXA-962       NG_074740.1 WP_052248074.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-962
        blaOXA-963       NG_074741.1 WP_213994603.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-963
        blaOXA-964       NG_074742.1 WP_025889747.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-964
        blaOXA-965       NG_074743.1 WP_213994604.1     OXA-55 family carbapenem-hydrolyzing class D beta-lactamase OXA-965
        blaPDC-477       NG_074744.1 WP_213994605.1     class C beta-lactamase PDC-477
        blaPDC-478       NG_074745.1 WP_213994606.1     class C beta-lactamase PDC-478
        blaPDC-479       NG_074746.1 WP_213994607.1     class C beta-lactamase PDC-479
        blaPDC-480       NG_074747.1 WP_213994608.1     class C beta-lactamase PDC-480
        blaPDC-481       NG_074748.1 WP_213994609.1     class C beta-lactamase PDC-481
        blaPDC-482       NG_074749.1 WP_213994610.1     class C beta-lactamase PDC-482
        blaPDC-483       NG_074750.1 WP_213994611.1     class C beta-lactamase PDC-483
        blaROB-11        NG_074751.1 WP_132995818.1     class A beta-lactamase ROB-11
        blaROB-12        NG_074752.1 WP_213994612.1     class A beta-lactamase ROB-12
        blaROB-9         NG_074753.1 WP_172693371.1     class A beta-lactamase ROB-9
        blaVIM-74        NG_074754.1 WP_213994613.1     subclass B1 metallo-beta-lactamase VIM-74
        mcr-1.31         NG_074755.1 WP_213994614.1     phosphoethanolamine--lipid A transferase MCR-1.31
        mcr-1.32         NG_074756.1 WP_213994615.1     phosphoethanolamine--lipid A transferase MCR-1.32
        mcr-8.4          NG_074757.1 WP_118860654.1     phosphoethanolamine--lipid A transferase MCR-8.4
        qnrE3            NG_074758.1 WP_010431379.1     quinolone resistance pentapeptide repeat protein QnrE3
        qnrE4            NG_074759.1 WP_047174394.1     quinolone resistance pentapeptide repeat protein QnrE4
        qnrVC8           NG_074760.1 WP_206627591.1     quinolone resistance pentapeptide repeat protein QnrVC8
    plus AMR AMR
        catC             JPIP01000949.1 KGT34314.1      type B chloramphenicol O-acetyltransferase
    plus VIRULENCE VIRULENCE
        seh              U11702.1 AAA19777.1            staphylococcal enterotoxin type H
        see              M21319.1 AAA26617.1            staphylococcal enterotoxin type E
        sec2             M28364.1 AAA26624.1            staphylococcal enterotoxin type C2
        eta              M17347.1 AAA26625.1            exfoliative toxin A
        etb              M17348.1 AAA26628.1            exfoliative toxin B
        tst              J02615.1 AAA26682.1            toxic shock syndrome toxin TSST-1
        seb              M11118.1 AAA88550.1            staphylococcal enterotoxin type B
        sed              M28521.1 AAB06195.1            staphylococcal enterotoxin type D
        sej              AF053140.1 AAC78590.1          staphylococcal enterotoxin type J
        iucD             AF141323.1 AAD44749.1          NADPH-dependent L-lysine N(6)-monooxygenase IucD
        iucC             AE014075.1 AAN82073.1          NIS family aerobactin synthetase IucC
        iucB             AE014075.1 AAN82074.1          N(6)-hydroxylysine O-acetyltransferase IucB
        rmpA2            AY378100.1 AAR07704.1          mucoid phenotype regulator RmpA2
        sek              CP000046.1 AAW36439.1          staphylococcal enterotoxin type K
        splE             CP000253.1 ABD30999.1          serine protease SplE
        splB             CP000253.1 ABD31003.1          serine protease SplB
        splA             CP000253.1 ABD31004.1          serine protease SplA
        selV             EF030427.1 ABK27165.1          staphylococcal enterotoxin type V
        iroD             CP001232.1 ACJ63529.1          catecholate siderophore esterase IroD
        sel31            GQ900475.1 ACZ66176.1          staphylococcal enterotoxin type 31
        sep              CP001844.2 ADC38120.1          staphylococcal enterotoxin type P
        scn              CP002114.2 ADL23798.1          complement inhibitor SCIN-A
        selX             HQ850970.1 AEI60187.1          staphylococcal enterotoxin-like toxin X
        lukS-PV          CP003603.1 AGW33874.1          Panton-Valentine bi-component leukocidin subunit S
        rmpC             CP009208.1 AIK83625.1          mucoid phenotype regulator RmpC
        rmpA             CP014009.1 AMA27886.1          mucoid phenotype regulator RmpA
        sel              CP014064.2 AMG40538.1          staphylococcal enterotoxin type L
        iroC             MG649035.1 AUH19662.1          salmochelin/enterobactin export ABC transporter IroC
        rmpD             CP025630.1 AUN52700.1          mucoid phenotype synthesis protein RmpD
        hlgA             CP026068.1 AUU54669.1          bi-component gamma-hemolysin HlgAB subunit A
        icaC             CP026070.1 AUU58561.1          polysaccharide intercellular adhesin biosynthesis/export protein IcaC
        iroD             KY454627.1 AVE24993.1          catecholate siderophore esterase IroD
        ednB             MH115577.1 AXN77488.1          epidermal cell differentiation inhibitor EdnB
        lukF-PV          AB006796.1 BAA24008.1          Panton-Valentine bi-component leukocidin subunit F
        seo              BA000018.3 BAB42916.1          staphylococcal enterotoxin type O
        sec3             BA000018.3 BAB43097.1          staphylococcal enterotoxin type C3
        cna              BA000033.2 BAB96477.1          collagen adhesin Cna
        set              AB330135.1 BAG06666.1          staphylococcal enterotoxin type T
        ses              AB330135.1 BAG06667.1          staphylococcal enterotoxin type S
        sey              AB924045.1 BAS21358.1          staphylococcal enterotoxin type Y
        sea              LC129040.1 BAV60816.1          staphylococcal enterotoxin type A
        sak              X00127.1 CAA24957.1            staphylokinase
        sec1             X05815.1 CAA29260.1            staphylococcal enterotoxin type C1
        hlgC             X81586.1 CAA57277.1            bi-component gamma-hemolysin HlgCB subunit C
        hlgB             X81586.1 CAA57278.1            bi-component gamma-hemolysin HlgAB/HlgCB subunit B
        lukD             Y13225.1 CAA73668.1            bi-component leukocidin LukED subunit D
        sel33            FGMI01000018.1 CXT91862.1      staphylococcal enterotoxin type 33
        sel32            AFTU01000025.1 EGS90476.1      staphylococcal enterotoxin type 32
        iroB             ASVE01000004.1 EOW04219.1      salmochelin biosynthesis C-glycosyltransferase IroB
        ser              JDNQ01000016.1 EVY93839.1      staphylococcal enterotoxin type R
        seq              JGOY01000001.1 EYN56163.1      staphylococcal enterotoxin type Q
        sel26            JIJZ01000001.1 KAG18833.1      staphylococcal enterotoxin type 26
        sel27            JAAFMT010000017.1 NDR16746.1   staphylococcal enterotoxin type 27
        sel28            JAAFMT010000017.1 NDR16747.1   staphylococcal enterotoxin type 28
        rmpD             MT035874.1 QIK04195.1          mucoid phenotype synthesis protein RmpD
        sen              FKWK01000010.1 SAO78304.1      staphylococcal enterotoxin type N
        seu              FQDL01000019.1 SGR88168.1      staphylococcal enterotoxin type U
        sei              FQDL01000019.1 SGR88193.1      staphylococcal enterotoxin type I
        sem              FQDL01000019.1 SGR88215.1      staphylococcal enterotoxin type M
        selZ             UHAS01000001.1 SUK32596.1      staphylococcal enterotoxin type Z
        sel30            UHBH01000001.1 SUK66413.1      staphylococcal enterotoxin type 30
Added point mutations
    core AMR POINT
        acrR_M109I       TIGECYCLINE Klebsiella
        acrR_V165I       TIGECYCLINE Klebsiella
        acrR_Y114F       TIGECYCLINE Klebsiella
        gyrA_S83I        QUINOLONE Salmonella
        oqxR_D95E        TIGECYCLINE Klebsiella
        oqxR_F6S         TIGECYCLINE Klebsiella
        oqxR_Q11L        TIGECYCLINE Klebsiella
        oqxR_V102G       TIGECYCLINE Klebsiella
        oqxR_V113I       TIGECYCLINE Klebsiella
        ramR_A16D        TIGECYCLINE Klebsiella
        ramR_A183D       TIGECYCLINE Klebsiella
        ramR_A19V        TIGECYCLINE Klebsiella
        ramR_I88N        TIGECYCLINE Klebsiella
        ramR_K5E         TIGECYCLINE Klebsiella
        ramR_T162I       TIGECYCLINE Klebsiella
        ramR_T43M        TIGECYCLINE Klebsiella
        rpsJ_V57L        TIGECYCLINE Klebsiella
Changed reference gene catalog records
    aac(3)-Ih ABL71428.1
        scope:           core -> plus
    arsR AAA25636.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    copC AAA25808.1
        class:           <empty> -> COPPER
        subclass:        <empty> -> COPPER
    arsR AAA27587.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    nccX AAA65102.1
        class:           <empty> -> CADMIUM/COBALT/NICKEL
        subclass:        <empty> -> CADMIUM/COBALT/NICKEL
    arsR AAB09624.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    iutA AAN45165.2
        pubmed_reference: <empty> -> 21108814, 30371343
    arsR ADZ44504.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    arsR BAE77793.1
        class:           <empty> -> ARSENIC
        subclass:        <empty> -> ARSENIC
    iucA EGI25746.1
        pubmed_reference: <empty> -> 30371343, 32432457
    pbp2x WP_000872264.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872267.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872270.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872271.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872273.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872275.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872277.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_000872282.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp1a WP_001039998.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp1a WP_001040004.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp1a WP_001040010.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp1a WP_001040013.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp2b WP_001224867.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    pbp2b WP_001224871.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    pbp2b WP_001224884.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    pbp2b WP_001224885.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    pbp2b WP_001224886.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    apmA WP_015059965.1
        subclass:        AMINOGLYCOSIDE -> APRAMYCIN
    apmA WP_032494221.1
        pubmed_reference: 20876371 -> 20876371, 33563840
        subclass:        AMINOGLYCOSIDE -> APRAMYCIN
    pbp2x WP_033707918.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp1a WP_050078510.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp1a WP_050208712.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp2x WP_050293540.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp2x WP_054364452.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    pbp1a WP_054370471.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp1a -> Streptococcus pneumoniae beta-lactam resistant PBP1A
    pbp2b WP_061634854.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2b -> Streptococcus pneumoniae beta-lactam resistant PBP2B
    pbp2x WP_061745305.1
        product_name:    Streptococcus pneumoniae beta-lactam resistant Pbp2x -> Streptococcus pneumoniae beta-lactam resistant PBP2X
    blaNDM-16a WP_063860859.1
        allele:          blaNDM-16 -> blaNDM-16a
        product_name:    subclass B1 metallo-beta-lactamase NDM-16 -> subclass B1 metallo-beta-lactamase NDM-16a
    cfiA WP_005808062.1
        allele:          cfiA13 -> cfiA
        product_name:    subclass B1 metallo-beta-lactamase CcrA -> subclass B1 metallo-beta-lactamase CfiA/CcrA

Added families
    catC             -                              type B chloramphenicol O-acetyltransferase
    cna              -                              collagen adhesin Cna
    ednB             -                              epidermal cell differentiation inhibitor EdnB
    eta              -                              exfoliative toxin A
    etb              -                              exfoliative toxin B
    hlgA             -                              bi-component gamma-hemolysin HlgAB subunit A
    hlgB             -                              bi-component gamma-hemolysin HlgAB/HlgCB subunit B
    hlgC             -                              bi-component gamma-hemolysin HlgCB subunit C
    icaC             -                              polysaccharide intercellular adhesin biosynthesis/export protein IcaC
    iroB             -                              salmochelin biosynthesis C-glycosyltransferase IroB
    iroC             -                              salmochelin/enterobactin export ABC transporter IroC
    iroD             -                              catecholate siderophore esterase IroD
    iucB             -                              N(6)-hydroxylysine O-acetyltransferase IucB
    iucC             -                              NIS family aerobactin synthetase IucC
    iucD             -                              NADPH-dependent L-lysine N(6)-monooxygenase IucD
    lukD             -                              bi-component leukocidin LukED subunit D
    lukF-PV          -                              Panton-Valentine bi-component leukocidin subunit F
    lukS-PV          -                              Panton-Valentine bi-component leukocidin subunit S
    mef(F)           -                              macrolide efflux MFS transporter Mef(F)
    mexC             -                              MexC family multidrug efflux RND transporter periplasmic adaptor subunit
    mexD             -                              multidrug efflux RND transporter permease subunit MexD
    oprJ             -                              multidrug efflux transporter outer membrane subunit OprJ
    rmpA             -                              mucoid phenotype regulator RmpA
    rmpA2            -                              mucoid phenotype regulator RmpA2
    rmpC             -                              mucoid phenotype regulator RmpC
    rmpD             -                              mucoid phenotype synthesis protein RmpD
    sak              -                              staphylokinase
    scn              -                              complement inhibitor SCIN-A
    sea              -                              staphylococcal enterotoxin type A
    seb              -                              staphylococcal enterotoxin type B
    sec1             -                              staphylococcal enterotoxin type C1
    sec2             -                              staphylococcal enterotoxin type C2
    sec3             -                              staphylococcal enterotoxin type C3
    sed              -                              staphylococcal enterotoxin type D
    see              -                              staphylococcal enterotoxin type E
    seh              -                              staphylococcal enterotoxin type H
    sei              -                              staphylococcal enterotoxin type I
    sej              -                              staphylococcal enterotoxin type J
    sek              -                              staphylococcal enterotoxin type K
    sel              -                              staphylococcal enterotoxin type L
    sel26            -                              staphylococcal enterotoxin type 26
    sel27            -                              staphylococcal enterotoxin type 27
    sel28            -                              staphylococcal enterotoxin type 28
    sel30            -                              staphylococcal enterotoxin type 30
    sel31            -                              staphylococcal enterotoxin type 31
    sel32            -                              staphylococcal enterotoxin type 32
    sel33            -                              staphylococcal enterotoxin type 33
    selV             -                              staphylococcal enterotoxin type V
    selX             -                              staphylococcal enterotoxin-like toxin X
    selZ             -                              staphylococcal enterotoxin type Z
    sem              -                              staphylococcal enterotoxin type M
    sen              -                              staphylococcal enterotoxin type N
    seo              -                              staphylococcal enterotoxin type O
    sep              -                              staphylococcal enterotoxin type P
    seq              -                              staphylococcal enterotoxin type Q
    ser              -                              staphylococcal enterotoxin type R
    ses              -                              staphylococcal enterotoxin type S
    set              -                              staphylococcal enterotoxin type T
    seu              -                              staphylococcal enterotoxin type U
    sey              -                              staphylococcal enterotoxin type Y
    splA             -                              serine protease SplA
    splB             -                              serine protease SplB
    splE             -                              serine protease SplE
    tmexC1           -                              multidrug efflux RND transporter periplasmic adaptor subunit TMexC1
    tmexD1           -                              multidrug efflux RND transporter permease subunit TMexD1
    toprJ1           -                              multidrug efflux transporter outer membrane subunit TOprJ1
    tst              -                              toxic shock syndrome toxin TSST-1
Family changes
    dfrA             DfrA12/DfrA21 family trimethoprim-resistant dihydrofolate reductase
        hmm_id:          - -> NF000055.3

----------------------------------------------------------------------
Changes included in 2021-03-01.1
----------------------------------------------------------------------

AMRFinderPlus database / Reference Gene Catalog version 2021-03-01.1
AMRFinderPlus software version 3.10.1

This is a significant update that includes reorganizations of two important
gene families (dfr and tet) as well as new functionality to handle Penicillin
resistant pbp alleles in Streptococcus pneumoniae. These updates required
changes to the database format and a new version of the AMRFinderPlus software.
More detailed explanations of major changes follow the summary.

To use this database release you will need to upgrade to an AMRFinderPlus
software version in the 3.10 series. See
https://github.com/ncbi/amr/wiki/Upgrading for details on how to upgrade the
AMRFinderPlus software.

Overview of notable changes:

- New handling of pbp alleles in Streptococcus pneumoniae where instead of
  identifying individual mutations AMRFinderPlus identifies divergent pbp
  alleles that are likely to be penicillin resistant
- Reorganization and/or renaming of some dfr and tet families with some symbol
  changes and new sequences added; A description and explanation are included
  below
- Some van genes were moved to the plus category, see below for an explanation
- Class and subclass and protein names were changed for several blaOXA and
  blaKPC alleles to reflect new information about their function
- We removed some HMMs that are not specific to AMR genes and have no effect on
  which proteins are reported
- Organism names were changed to match some GenBank records
- PubMed references added to 1,591 AMR genes in the Reference Gene Catalog. In
  the interest of clarity those additions are not listed below

Additional details:

Pencillin-resistant Streptococcus pneumoniae pbp alleles are defined as those
alleles which are below a protein identity threshold to a set of pbp1a, pbp2b,
or pbp2x reference alleles: the thresholds are 99%, 99%, and 98% for pbp1a,
pbp2b, and pbp2x respectively. The susceptible reference alleles can be found
in NCBI's Reference Gene Catalog. These alleles may also confer resistance to
other beta-lactam antibiotics. If you are using AMRFinderPlus with
Streptococcus pneumoniae pbp genes you may need to analyze further as
necessary. In the future Streptococcus pneumoniae will be added to MicroBIGG-E
and you will be able to download the sequence of the variant alleles there.

Some DfrA protein families were renamed or newly created, guided by advice from
Dr. Ruth Hall, after observation of accidental use of the same designations by
different groups for different proteins. For those DfrA proteins encoded within
integrons, NCBI recognizes that families can be defined narrowly, as sets of
proteins sharing 98% or more amino acid sequence identity, as that follows
common practice in the literature.

In general, NCBI follows the nomenclature maintained by Dr. Marilyn Roberts for
the naming of all tetracycline resistance (Tet) protein families, including the
tetracycline-inactivating monooxygenase Tet(X). However, in response to a
growing literature showing interest in subfamilies within the Tet(X) family, we
now provide assignments for subfamilies of Tet(X) with designations up through
Tet(X5), following Chen, et al. (PMID:33287863). Note that these designations
refer to subfamilies, not alleles. Designations beyond Tet(X5) that appear in
the literature probably should be considered provisional and subject to change.
We also now recognize several mosaic forms of tet genes related to tet(W) and
tet(O).

Five Van genes were moved from core to plus. These are genes that are found
exclusively in Clostridioides difficile, and, by themselves, do not confer
vancomycin resistance. Because they are found in most C. difficile, they have
been moved to plus since they are non-determinative for phenotype.

Note that listed below are sequences that were removed, generally these are
incorrect and replaced by corrected proteins.

Summary:
   Total proteins: 6650
        Core proteins: 5760
        Plus proteins: 890
   AMR proteins: 5800
   STRESS proteins: 211
   VIRULENCE proteins: 639
   Point mutations: 728
   Point mutation references: 104
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Staphylococcus_pseudintermedius,
       Streptococcus_agalactiae, Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 630

Updates since release 2020-12-17.1:
   Proteins added: 72
       Core proteins added: 71
       Plus proteins added: 1
   AMR proteins added: 71
   VIRULENCE proteins added: 1
   Alleles added: 34
   Point mutations added: 15
   Proteins removed: 2
       Core proteins removed: 2
       Plus proteins removed: 0
   Point mutations removed 12
   Reference Gene Catalog entries changed: 40
   Families added: 31
   Families removed: 2
   Families changed: 8

Added proteins
    core AMR AMR
        dfrA4            NG_073445.1 WP_011977799.1     trimethoprim-resistant dihydrofolate reductase DfrA4
        tet(O/W/32/O)    NG_073452.1 WP_013646121.1     tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
        fosM2            NG_073449.1 WP_066187568.1     fosfomycin resistance protein FosM2
        fosM1            NG_073448.1 WP_102272729.1     fosfomycin resistance protein FosM1
        tet(X5)          NG_073455.1 WP_150378267.1     tetracycline-inactivating monooxygenase Tet(X5)
        dfrA48           NG_073572.1 WP_173288987.1     trimethoprim-resistant dihydrofolate reductase DfrA48
        tet(O/W)         NG_073451.1 WP_204313008.1     tetracycline resistance ribosomal protection mosaic protein Tet(O/W)
        tet(W/32/O)      NG_073453.1 WP_204313011.1     tetracycline resistance ribosomal protection mosaic protein Tet(W/32/O)
        dfrA25           NG_065841.2 WP_204376219.1     trimethoprim-resistant dihydrofolate reductase DfrA25
        dfrA44           NG_073446.1 WP_204376220.1     trimethoprim-resistant dihydrofolate reductase DfrA44
        fosM3            NG_073450.1 WP_204376221.1     fosfomycin resistance protein FosM3
        tet(X1)          NG_073454.1 WP_204376222.1     tetracycline-inactivating monooxygenase Tet(X1)
        blaADC-256       NG_073457.1 WP_204376223.1     class C beta-lactamase ADC-256
        blaAFM-2         NG_073458.1 WP_204376224.1     subclass B1 metallo-beta-lactamase AFM-2
        blaCMY-174       NG_073459.1 WP_200302238.1     class C beta-lactamase CMY-174
        blaCTX-M-244     NG_073460.1 WP_204376225.1     class A extended-spectrum beta-lactamase CTX-M-244
        blaEBR-4         NG_073461.1 WP_114999921.1     subclass B1 metallo-beta-lactamase EBR-4
        blaFRI-10        NG_073462.1 WP_204376226.1     carbapenem-hydrolyzing class A beta-lactamase FRI-10
        blaGMB-1         NG_073463.1 WP_204376227.1     subclass B1 metallo-beta-lactamase GMB-1
        blaIMI-21        NG_073464.1 WP_204376228.1     carbapenem-hydrolyzing class A beta-lactamase IMI-21
        blaKPC-62        NG_073465.1 WP_204376229.1     class A beta-lactamase KPC-62
        blaKPC-63        NG_073466.1 WP_204376230.1     class A beta-lactamase KPC-63
        blaKPC-64        NG_073467.1 WP_204376231.1     class A beta-lactamase KPC-64
        blaKPC-65        NG_073468.1 WP_204376232.1     class A beta-lactamase KPC-65
        blaKPC-80        NG_073469.1 WP_204376233.1     carbapenem-hydrolyzing class A beta-lactamase KPC-80
        blaKPC-81        NG_073470.1 WP_204376234.1     carbapenem-hydrolyzing class A beta-lactamase KPC-81
        blaKPC-82        NG_073471.1 WP_202781289.1     inhibitor-resistant class A beta-lactamase KPC-82
        blaOXA-927       NG_073472.1 WP_047480628.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-927
        blaOXA-945       NG_073473.1 WP_204376235.1     OXA-143 family carbapenem-hydrolyzing class D beta-lactamase OXA-945
        blaOXA-946       NG_073474.1 WP_204376236.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-946
        blaOXA-947       NG_073475.1 WP_204376237.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-947
        blaOXA-948       NG_073476.1 WP_204376238.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-948
        blaOXA-949       NG_073477.1 WP_204376239.1     OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-949
        blaPDC-467       NG_073478.1 WP_204376240.1     class C beta-lactamase PDC-467
        blaPDC-468       NG_073479.1 WP_204376241.1     class C beta-lactamase PDC-468
        blaPDC-469       NG_073480.1 WP_204376242.1     class C beta-lactamase PDC-469
        blaPDC-470       NG_073481.1 WP_204376243.1     class C beta-lactamase PDC-470
        blaPDC-471       NG_073482.1 WP_204376244.1     class C beta-lactamase PDC-471
        blaPDC-472       NG_073483.1 WP_204376245.1     class C beta-lactamase PDC-472
        blaPDC-473       NG_073489.1 WP_204378708.1     class C beta-lactamase PDC-473
        blaPDC-474       NG_073490.1 WP_204378709.1     class C beta-lactamase PDC-474
        blaPDC-475       NG_073491.1 WP_204378710.1     class C beta-lactamase PDC-475
        blaPDC-476       NG_073492.1 WP_204378711.1     class C beta-lactamase PDC-476
        blaPER-16        NG_073484.1 WP_202089433.1     class A extended-spectrum beta-lactamase PER-16
        fosU1            NG_073485.1 WP_204376246.1     fosfomycin resistance glutathione transferase FosU1
        fosU2            NG_073486.1 WP_204376247.1     fosfomycin resistance glutathione transferase FosU2
    core AMR AMR-SUSCEPTIBLE
        pbp2x            ALCO01000001.1 EJH07906.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            MLGJ01000011.1 OIB10928.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            JAAAQR010000224.1 NMG91507.1   Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            CP002121.1 ADM83960.1          Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            CNXL02000011.1 CTF03593.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            AE005672.3 AAK74511.1          Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            UHGH01000001.1 SUO05487.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            UYIP01000001.1 VDG79030.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp1a            WNHU01000041.1 MTV43544.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            UHGV01000002.1 SUO36701.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            CP002121.1 ADM83986.1          Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            AE005672.3 AAK74536.1          Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp2b            UHGI01000001.1 SUO08321.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            FQ312027.1 CBW33123.1          Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            ALAW01000018.1 EJG35019.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            CP002121.1 ADM85262.1          Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2b            FFQV01000008.1 CXF06025.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2x            LJMO01000139.1 KYA87151.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp1a            UHGB01000001.1 SUN90660.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp1a            UHFY01000001.1 SUN89985.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp2x            LWGW01000042.1 OCQ83618.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp2x            CNPV02000129.1 CTH70606.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
        pbp1a            CNZD02000033.1 CTN64071.1      Streptococcus pneumoniae beta-lactam resistant Pbp1a
        pbp2b            FHTX02000001.1 VJH99099.1      Streptococcus pneumoniae beta-lactam resistant Pbp2b
        pbp2x            FHSK02000014.1 VMM09393.1      Streptococcus pneumoniae beta-lactam resistant Pbp2x
    plus VIRULENCE VIRULENCE
        cdtB             AL513382.1 CAD02120.1          cytolethal distending toxin S-CDT
Added point mutations
    core AMR POINT
        grlA_D84G        QUINOLONE Staphylococcus_pseudintermedius
        grlA_D84H        QUINOLONE Staphylococcus_pseudintermedius
        grlA_D84N        QUINOLONE Staphylococcus_pseudintermedius
        grlA_D84Y        QUINOLONE Staphylococcus_pseudintermedius
        grlA_S80I        QUINOLONE Staphylococcus_pseudintermedius
        grlA_S80R        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_E88G        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_E88K        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S84A        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S84L        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S84W        QUINOLONE Staphylococcus_pseudintermedius
        gyrA_S85A        QUINOLONE Staphylococcus_pseudintermedius
        rpoB_A473AA      RIFAMPIN Staphylococcus_pseudintermedius
        rpoB_H481Y       RIFAMPIN Staphylococcus_pseudintermedius
        rpoB_S486L       RIFAMPIN Staphylococcus_pseudintermedius
Removed proteins
    core AMR AMR
        dfrA29           NG_065841.1 WP_148044403.1     trimethoprim-resistant dihydrofolate reductase DfrA29
        mcr-3.30         NG_065456.1 WP_140423332.1     phosphoethanolamine--lipid A transferase MCR-3.30
Proteins reclassified from 'core' to 'plus'
        vanR-Cd          NG_061618.1 WP_003436401.1     VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
        vanZ1            NG_061614.1 WP_009889012.1     glycopeptide resistance protein VanZ1
        vanS-Cd          NG_061619.1 WP_011861275.1     VanG-Cd-type vancomycin resistance histidine kinase VanS
        vanG             NG_061616.1 WP_011861276.1     D-alanine--D-serine ligase VanG-Cd
        vanT-Cd          NG_052046.1 WP_071593222.1     membrane-bound serine racemase VanT-Cd
Removed point mutations
    core AMR POINT
        pbp1a_N609D      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_S575T      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_T371S      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_E476G      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T446A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T489A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_I371T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_L546V      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M339T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M400T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N514H      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N605T      BETA-LACTAM Streptococcus_pneumoniae
Changed reference gene catalog records
    dfrA27 WP_001749985.1
        allele:          dfrA27 -> <empty>
        gene_family:     dfrA -> dfrA27
    tet(O/M/O) WP_002872163.1
        gene_family:     tet(O) -> tet(O/M/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(O) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/M/O)
    fosX WP_003726635.1
        product_name:    fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX
    dfrA21 WP_004187529.1
        allele:          dfrA21 -> <empty>
        gene_family:     dfrA -> dfrA21
    tet(X2) WP_008651082.1
        gene_family:     tet(X) -> tet(X2)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2)
    fosX WP_010989789.1
        product_name:    fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX
    fosI WP_014714131.1
        allele:          fosI -> <empty>
        gene_family:     fosX -> fosI
        product_name:    fosfomycin resistance thiol transferase FosI -> fosfomycin resistance hydrolase FosI
    tet(X2) WP_015060600.1
        gene_family:     tet(X) -> tet(X2)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2)
    tet(X3) WP_015060917.1
        gene_family:     tet(X) -> tet(X3)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X3)
    tet(O/32/O) WP_015573056.1
        gene_family:     tet(32) -> tet(O/32/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(32) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/32/O)
    fosX WP_015860243.1
        product_name:    FosX/FosE/FosI family fosfomycin resistance thiol transferase -> FosX/FosE/FosI family fosfomycin resistance hydrolase
    tet(X3) WP_024160783.1
        gene_family:     tet(X) -> tet(X3)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X3)
    tet(W/N/W) WP_024963478.1
        gene_family:     tet(W) -> tet(W/N/W)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W)
    dfrA32 WP_032084013.1
        allele:          dfrA32 -> <empty>
        gene_family:     dfrA -> dfrA32
    dfrA47 WP_034072810.1
        gene_family:     dfrA22 -> dfrA47
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA47
    dfrA29 WP_045899678.1
        gene_family:     dfr7 -> dfrA29
        product_name:    trimethoprim-resistant dihydrofolate reductase Dfr7 -> trimethoprim-resistant dihydrofolate reductase DfrA29
    tet(O/W/O) WP_054336482.1
        gene_family:     tet(W) -> tet(O/W/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O)
    fosE WP_054882068.1
        product_name:    fosfomycin resistance thiol transferase FosE -> fosfomycin resistance hydrolase FosE
    dfrA33 WP_063844371.1
        gene_family:     dfrA22 -> dfrA33
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA33
    dfrA46 WP_063844461.1
        gene_family:     dfrA6 -> dfrA46
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA6 -> trimethoprim-resistant dihydrofolate reductase DfrA46
    tet(O/W/32/O) WP_063856419.1
        gene_family:     tet(W) -> tet(O/W/32/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
    tet(O/W/32/O) WP_063856420.1
        gene_family:     tet(W) -> tet(O/W/32/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
    tet(O/W/O) WP_063856421.1
        gene_family:     tet(W) -> tet(O/W/O)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O)
    tet(X2) WP_063856436.1
        gene_family:     tet(X) -> tet(X2)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X2)
    tet(X5) WP_063856444.1
        gene_family:     tet(X) -> tet(X5)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X5)
    dfrA33 WP_071846242.1
        gene_family:     dfrA22 -> dfrA33
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA22 -> trimethoprim-resistant dihydrofolate reductase DfrA33
    tet(X4) WP_094309310.1
        gene_family:     tet(X) -> tet(X4)
        product_name:    tetracycline-inactivating monooxygenase Tet(X) -> tetracycline-inactivating monooxygenase Tet(X4)
    tet(W/N/W) WP_122634437.1
        gene_family:     tet(W) -> tet(W/N/W)
        product_name:    tetracycline resistance ribosomal protection protein Tet(W) -> tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W)
    blaADC-8 WP_004923134.1
        product_name:    cephalosporin-hydrolyzing class C beta-lactamase ADC-8 -> ADC-like class C beta-lactamase ADC-8
    blaCTX-M-151 WP_063859960.1
        product_name:    class A extended-spectrum beta-lactamase CTX-M-151 -> CTX-M-like class A extended-spectrum beta-lactamase CTX-M-151
    blaKPC-53 WP_156649232.1
        product_name:    carbapenem-hydrolyzing class A beta-lactamase KPC-53 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-53
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-66 WP_188331871.1
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-72 WP_188331872.1
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-73 WP_188331873.1
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaKPC-79 WP_197749404.1
        product_name:    class A beta-lactamase KPC-79 -> inhibitor-resistant class A extended-spectrum beta-lactamase KPC-79
        subclass:        CARBAPENEM -> CEPHALOSPORIN
    blaOXA-427 WP_096807440.1
        product_name:    class D beta-lactamase OXA-427 -> carbapenem-hydrolyzing class D beta-lactamase OXA-427
    blaOXA-679 WP_122634439.1
        product_name:    OXA-667 family class D beta-lactamase OXA-679 -> carbapenem-hydrolyzing class D beta-lactamase OXA-679
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-730 WP_116786836.1
        product_name:    class D beta-lactamase OXA-730 -> OXA-679 family carbapenem-hydrolyzing class D beta-lactamase OXA-730
        subclass:        BETA-LACTAM -> CARBAPENEM
    blaOXA-917 WP_161507793.1
        product_name:    class D beta-lactamase OXA-917 -> carbapenem-hydrolyzing class D beta-lactamase OXA-917
    fosH WP_063851233.1
        product_name:    fosfomycin resistance thiol transferase FosH -> fosfomycin resistance hydrolase FosH

Added families
    cdtB             -                              cytolethal distending toxin S-CDT
    blaGMB           NF038103.1                     GMB family subclass B1 metallo-beta-lactamase
    blaOXA           NF038333.1                     blaOXA-679 family carbapenem-hydrolyzing class D beta-lactamase
    dfrA             -                              DfrA12/DfrA21 family trimethoprim-resistant dihydrofolate reductase
    dfrA21           -                              trimethoprim-resistant dihydrofolate reductase DfrA21
    dfrA27           -                              trimethoprim-resistant dihydrofolate reductase DfrA27
    dfrA32           -                              trimethoprim-resistant dihydrofolate reductase DfrA32
    dfrA33           -                              trimethoprim-resistant dihydrofolate reductase DfrA33
    dfrA4            -                              trimethoprim-resistant dihydrofolate reductase DfrA4
    dfrA44           -                              trimethoprim-resistant dihydrofolate reductase DfrA44
    dfrA46           -                              trimethoprim-resistant dihydrofolate reductase DfrA46
    dfrA47           -                              trimethoprim-resistant dihydrofolate reductase DfrA47
    dfrA48           -                              trimethoprim-resistant dihydrofolate reductase DfrA48
    fosI             -                              fosfomycin resistance hydrolase FosI
    fosM             NF038306.1                     FosM family fosfomycin resistance protein
    fosM1            -                              fosfomycin resistance protein FosM1
    fosM2            -                              fosfomycin resistance protein FosM2
    fosM3            -                              fosfomycin resistance protein FosM3
    fosU             NF038311.1                     FosU family fosfomycin resistance glutathione transferase
    tet(O/32/O)      -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/32/O)
    tet(O/M/O)       -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/M/O)
    tet(O/W)         -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/W)
    tet(O/W/32/O)    -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/W/32/O)
    tet(O/W/O)       -                              tetracycline resistance ribosomal protection mosaic protein Tet(O/W/O)
    tet(W/32/O)      -                              tetracycline resistance ribosomal protection mosaic protein Tet(W/32/O)
    tet(W/N/W)       -                              tetracycline resistance ribosomal protection mosaic protein Tet(W/N/W)
    tet(X1)          -                              tetracycline-inactivating monooxygenase Tet(X1)
    tet(X2)          -                              tetracycline-inactivating monooxygenase Tet(X2)
    tet(X3)          -                              tetracycline-inactivating monooxygenase Tet(X3)
    tet(X4)          -                              tetracycline-inactivating monooxygenase Tet(X4)
    tet(X5)          -                              tetracycline-inactivating monooxygenase Tet(X5)
Removed families
    dfr7             -                              trimethoprim-resistant dihydrofolate reductase Dfr7
    dfrA             NF000055.3                     DfrA13/DfrA21 family trimethoprim-resistant dihydrofolate reductase
Family changes
    -                multidrug efflux RND transporter permease subunit
        hmm_id:          NF000282.2 -> -
    adeC             AdeC/AdeK/OprM family multidrug efflux complex outer membrane factor
        hmm_id:          NF000315.1 -> -
    blaADC           ADC-like cephalosporin-hydrolyzing class C beta-lactamase
        family_name:     ADC-8-like cephalosporin-hydrolyzing class C beta-lactamase -> ADC-like cephalosporin-hydrolyzing class C beta-lactamase
    fosE             fosfomycin resistance hydrolase FosE
        family_name:     fosfomycin resistance thiol transferase FosE -> fosfomycin resistance hydrolase FosE
    fosX             fosfomycin resistance hydrolase FosX
        family_name:     fosfomycin resistance thiol transferase FosX -> fosfomycin resistance hydrolase FosX
    fosX             FosX/FosE/FosI family fosfomycin resistance hydrolase
        family_name:     FosX/FosE/FosI family fosfomycin resistance thiol transferase -> FosX/FosE/FosI family fosfomycin resistance hydrolase
    mexX             MexX/AmrA family multidrug efflux RND transporter periplasmic adaptor subunit
        hmm_id:          NF000252.1 -> -
    -                phosphoethanolamine--lipid A transferase
        hmm_id:          NF028537.1 -> -
----------------------------------------------------------------------
Changes included in 2020-12-17.1
----------------------------------------------------------------------
Highlights:

- Changed eae from subclass ANTIGEN to subclass VIRULENCE
- Some recategorization of eae genes
- Hybrid gene symbols added to fusion genes in the reference gene catalog (e.g., aac(6')-Ie/aph(2'')-Ia)
- Many new beta-lactamase alleles especially blaADCs and blaOXAs
- Some new Staphylococcus virulence gene families

Summary:
   Total proteins: 6580
        Core proteins: 5696
        Plus proteins: 884
   AMR proteins: 5731
   STRESS proteins: 211
   VIRULENCE proteins: 638
   Point mutations: 725
   Point mutation references: 104
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 631

Updates since release 2020-11-09.1:
   Proteins added: 61
       Core proteins added: 56
       Plus proteins added: 5
   AMR proteins added: 56
   VIRULENCE proteins added: 5
   Alleles added: 49
   Reference Gene Catalog entries changed: 82
   Families added: 11
   Families removed: 1
   Families changed: 8

Added proteins
    core AMR AMR
        dfrA42           NG_071176.1 WP_045475347.1     trimethoprim-resistant dihydrofolate reductase DfrA42
        tet(63)          NG_071181.1 WP_050437591.1     tetracycline efflux MFS transporter Tet(63)
        msr(G)           NG_071179.1 WP_101035417.1     ABC-F type ribosomal protection protein Msr(G)
        tet(64)          NG_071182.1 WP_124470450.1     tetracycline efflux MFS transporter Tet(64)
        lsa(D)           NG_071178.1 WP_165713684.1     ABC-F type ribosomal protection protein Lsa(D)
        dfrA38           NG_071175.1 WP_197749399.1     trimethoprim-resistant dihydrofolate reductase DfrA38
        tet(62)          NG_071180.1 WP_197749400.1     tetracycline efflux MFS transporter Tet(62)
        blaADC-237       NG_071183.1 WP_086262823.1     class C beta-lactamase ADC-237
        blaADC-238       NG_071184.1 WP_002058891.1     class C beta-lactamase ADC-238
        blaADC-239       NG_071185.1 WP_031981814.1     class C beta-lactamase ADC-239
        blaADC-240       NG_071186.1 WP_001211207.1     class C beta-lactamase ADC-240
        blaADC-241       NG_071187.1 WP_001211198.1     class C beta-lactamase ADC-241
        blaADC-242       NG_071188.1 WP_047481394.1     class C beta-lactamase ADC-242
        blaADC-243       NG_071189.1 WP_001211199.1     class C beta-lactamase ADC-243
        blaADC-244       NG_071190.1 WP_032017586.1     class C beta-lactamase ADC-244
        blaADC-245       NG_071191.1 WP_032005249.1     class C beta-lactamase ADC-245
        blaADC-246       NG_071192.1 WP_031976577.1     class C beta-lactamase ADC-246
        blaADC-247       NG_071193.1 WP_032058755.1     class C beta-lactamase ADC-247
        blaADC-248       NG_071194.1 WP_021511005.1     class C beta-lactamase ADC-248
        blaADC-249       NG_071195.1 WP_001211200.1     class C beta-lactamase ADC-249
        blaADC-250       NG_071196.1 WP_086329657.1     class C beta-lactamase ADC-250
        blaADC-251       NG_071197.1 WP_086443396.1     class C beta-lactamase ADC-251
        blaADC-252       NG_071198.1 WP_086399847.1     class C beta-lactamase ADC-252
        blaADC-253       NG_071199.1 WP_086394244.1     class C beta-lactamase ADC-253
        blaADC-254       NG_071200.1 WP_031996777.1     class C beta-lactamase ADC-254
        blaADC-255       NG_071201.1 WP_022575343.1     class C beta-lactamase ADC-255
        blaGES-46        NG_071202.1 WP_197749401.1     class A beta-lactamase GES-46
        blaKPC-49        NG_071203.1 WP_197749402.1     carbapenem-hydrolyzing class A beta-lactamase KPC-49
        blaKPC-78        NG_071204.1 WP_197749403.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-78
        blaKPC-79        NG_071205.1 WP_197749404.1     class A beta-lactamase KPC-79
        blaNDM-30        NG_071206.1 WP_197749405.1     subclass B1 metallo-beta-lactamase NDM-30
        blaNDM-31        NG_071207.1 WP_197749406.1     subclass B1 metallo-beta-lactamase NDM-31
        blaOXA-936       NG_071208.1 WP_004641493.1     OXA-214 family carbapenem-hydrolyzing class D beta-lactamase OXA-936
        blaOXA-937       NG_071209.1 WP_034081711.1     OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-937
        blaOXA-938       NG_071210.1 WP_086263559.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-938
        blaOXA-939       NG_071211.1 WP_086261538.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-939
        blaOXA-940       NG_071212.1 WP_086442870.1     OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-940
        blaOXA-941       NG_071213.1 WP_086395021.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-941
        blaOXA-942       NG_071214.1 WP_078225401.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-942
        blaOXA-943       NG_071215.1 WP_086398931.1     OXA-213 family carbapenem-hydrolyzing class D beta-lactamase OXA-943
        blaPDC-458       NG_071216.1 WP_197749407.1     class C beta-lactamase PDC-458
        blaPDC-459       NG_071217.1 WP_197749408.1     class C beta-lactamase PDC-459
        blaPDC-460       NG_071218.1 WP_197749409.1     class C beta-lactamase PDC-460
        blaPDC-461       NG_071219.1 WP_197749410.1     class C beta-lactamase PDC-461
        blaPDC-462       NG_071220.1 WP_197749411.1     class C beta-lactamase PDC-462
        blaPDC-463       NG_071221.1 WP_197749412.1     class C beta-lactamase PDC-463
        blaPDC-464       NG_071222.1 WP_197749413.1     class C beta-lactamase PDC-464
        blaPDC-465       NG_071223.1 WP_197749414.1     class C beta-lactamase PDC-465
        blaPDC-466       NG_071224.1 WP_197749415.1     class C beta-lactamase PDC-466
        blaTEM-103       NG_071225.1 WP_094353585.1     inhibitor-resistant class A broad-spectrum beta-lactamase TEM-103
        blaTEM-243       NG_071226.1 WP_197749416.1     class A beta-lactamase TEM-243
        cfiA26           NG_071227.1 WP_197749417.1     subclass B1 metallo-beta-lactamase CfiA26
        cfiA27           NG_071228.1 WP_197749418.1     subclass B1 metallo-beta-lactamase CfiA27
        cfiA28           NG_071229.1 WP_193683783.1     subclass B1 metallo-beta-lactamase CfiA28
        mcr-3.41         NG_071230.1 WP_181497495.1     phosphoethanolamine--lipid A transferase MCR-3.41
        qnrB93           NG_071231.1 WP_174771641.1     quinolone resistance pentapeptide repeat protein QnrB93
    plus VIRULENCE VIRULENCE
        hld              AF068634.1 AAC21574.1          delta-hemolysin
        hld              CP003979.1 AGU62139.1          delta-hemolysin
        lukE             Y13225.1 CAA73667.1            bi-component leukocidin LukED subunit E
        aur              AHJW01000015.1 EHO93748.1      zinc metalloproteinase aureolysin
        lukE             MSGQ01000028.1 RCV70079.1      bi-component leukocidin LukED subunit E
Changed reference gene catalog records
    eae AAF23359.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69110.1
        product_name:    intimin type beta -> intimin type kappa
        subclass:        BETA -> KAPPA
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69117.1
        product_name:    intimin type epsilon -> intimin type xi
        subclass:        EPSILON -> XI
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69121.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ABF69122.1
        product_name:    intimin type alpha -> intimin type nu
        subclass:        ALPHA -> NU
        subtype:         ANTIGEN -> VIRULENCE
    eae ABQ02454.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67143.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67145.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67146.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67148.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67149.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67152.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67153.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67154.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67155.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67156.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67157.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67158.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67160.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67161.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67162.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67163.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67164.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67165.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67166.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67167.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67168.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67169.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67172.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67177.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ACM67178.1
        subtype:         ANTIGEN -> VIRULENCE
    eae ADD58881.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL46940.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL46941.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47132.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47176.1
        product_name:    intimin type rho -> intimin type ypsilon
        subclass:        RHO -> YPSILON
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47179.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAL47181.1
        subtype:         ANTIGEN -> VIRULENCE
    eae BAT41861.1
        subtype:         ANTIGEN -> VIRULENCE
    eae CAI43865.1
        subtype:         ANTIGEN -> VIRULENCE
    eae CAS06720.1
        product_name:    intimin type gamma -> intimin type theta
        subclass:        GAMMA -> THETA
        subtype:         ANTIGEN -> VIRULENCE
    eae CAS06721.1
        product_name:    intimin type alpha -> intimin type zeta
        subclass:        ALPHA -> ZETA
        subtype:         ANTIGEN -> VIRULENCE
    eae CAS06723.1
        product_name:    intimin type alpha -> intimin type zeta
        subclass:        ALPHA -> ZETA
        subtype:         ANTIGEN -> VIRULENCE
    mef(A) WP_000417517.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_000417519.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    msr(D) WP_000420313.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    msr(D) WP_000420317.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(6')-Ie/aph(2'')-Ia WP_001028144.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-Ia
    mef(A) WP_012102963.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(6')-Ie/aph(2'')-Ia WP_012655884.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-Ia
    mef(A) WP_014636304.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_018374806.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_024127829.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(6')-Ie/aph(2'')-Ia WP_032490744.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-Ia
    aac(6')-Ie/aph(2'')-If2 WP_057097547.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')-If2
    mef(A) WP_058621816.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    aac(3)-Ib/aac(6')-Ib'' WP_063838852.1
        gene_family:     <empty> -> aac(3)-Ib/aac(6')-Ib''
    aac(6')-30/aac(6')-Ib' WP_063838853.1
        gene_family:     <empty> -> aac(6')-30/aac(6')-Ib'
    ant(3'')-Ij/aac(6')-Ib WP_063839875.1
        gene_family:     <empty> -> ant(3'')-Ij/aac(6')-Ib
    blaOXA/blaLRA13 WP_063839877.1
        gene_family:     <empty> -> blaOXA/blaLRA13
    ant(3'')-Ih/aac(6')-IId WP_063839878.1
        gene_family:     <empty> -> ant(3'')-Ih/aac(6')-IId
    mef(A) WP_063853554.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853563.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853574.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853591.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853602.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853625.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853632.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853638.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853648.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853682.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853689.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853698.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853705.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    mef(A) WP_063853713.1
        subclass:        MACROLIDE -> ERYTHROMYCIN
    ant(3'')-Ij/aac(6')-IIa WP_070342373.1
        gene_family:     <empty> -> ant(3'')-Ij/aac(6')-IIa
    catB8/aac(6')-Ib' WP_071593228.1
        gene_family:     <empty> -> catB8/aac(6')-Ib'
    estX/sat2 WP_071846307.1
        gene_family:     <empty> -> estX/sat2
    aac(6')-Ie/aph(2'') WP_122630840.1
        gene_family:     <empty> -> aac(6')-Ie/aph(2'')
    dfrA43 WP_188331861.1
        genbank_cds_start: 409 -> 6965
        genbank_cds_stop: 996 -> 7552
        genbank_nucleotide_accession: HQ386844.1 -> HQ386844.2
        gene_family:     dfrA38 -> dfrA43
        product_name:    trimethoprim-resistant dihydrofolate reductase DfrA38 -> trimethoprim-resistant dihydrofolate reductase DfrA43
    blaCARB-55 WP_071846358.1
        allele:          <empty> -> blaCARB-55
        product_name:    PSE family carbenicillin-hydrolyzing class A beta-lactamase -> PSE family carbenicillin-hydrolyzing class A beta-lactamase CARB-55
    blaOXA-917 WP_161507793.1
        subclass:        BETA-LACTAM -> CARBAPENEM

Added families
    aur              -                              zinc metalloproteinase aureolysin
    blaOXA           NF038217.1                     OXA-427 family carbapenem-hydrolyzing class D beta-lactamase
    dfrA42           -                              trimethoprim-resistant dihydrofolate reductase DfrA42
    dfrA43           -                              trimethoprim-resistant dihydrofolate reductase DfrA43
    hld              -                              delta-hemolysin
    lsa(D)           -                              ABC-F type ribosomal protection protein Lsa(D)
    lukE             -                              bi-component leukocidin LukED subunit E
    msr(G)           -                              ABC-F type ribosomal protection protein Msr(G)
    tet(62)          -                              tetracycline efflux MFS transporter Tet(62)
    tet(63)          -                              tetracycline efflux MFS transporter Tet(63)
    tet(64)          -                              tetracycline efflux MFS transporter Tet(64)
Removed families
    -                -
Family changes
    eae              intimin type nu
        family_name:     intimin type alpha -> intimin type nu
    eae              intimin type zeta
        family_name:     intimin type alpha -> intimin type zeta
    eae              intimin type kappa
        family_name:     intimin type beta -> intimin type kappa
    blaBUT           BUT family class C beta-lactamase
        hmm_id:          - -> NF038238.1
    eae              intimin type xi
        family_name:     intimin type epsilon -> intimin type xi
    eae              intimin type theta
        family_name:     intimin type gamma -> intimin type theta
    gar_fam          garosamine-type aminoglycoside resistance ATP-binding protein
        hmm_id:          - -> NF038208.1
    eae              intimin type ypsilon
        family_name:     intimin type rho -> intimin type ypsilon


----------------------------------------------------------------------
Changes included in 2020-11-09.1
----------------------------------------------------------------------
This release includes a change to the database format. It is compatible with
AMRFinderPlus versions in the 3.9 series. You will need to upgrade your
software to version 3.9 to use this database.

The database format change was necessitated by two changes in functionality.
(1) Alleles may now have different classes and subclasses from their parent
node.  (2) The blaEC family was moved to "plus", while specific alleles remain
reportable in the "core" set.

Other changes:
- Point mutations for Acenitobacter baumannii, Streptococcus_pneumoniae, and
  Streptococcus pyogenes were added
- A few families of plus AMR genes where presence/absence is not likely to
  impact phenotype were removed
- New core AMR families cml, gar, grdA
- Updates to provide more specific phenotype information for a few genes
- The usual new alleles of existing families

Note: It has come to our attention that the gene symbol for dfrA38 may conflict
with a publication. We are attempting to resolve the issue, so the symbol
dfrA38 may change.

Summary:
   Total proteins: 6519
        Core proteins: 5640
        Plus proteins: 879
   AMR proteins: 5675
   STRESS proteins: 211
   VIRULENCE proteins: 633
   Point mutations: 725
   Point mutation references: 104
   Point mutation organism groups:
       Acinetobacter_baumannii, Campylobacter, Enterococcus_faecalis, Enterococcus_faecium,
       Escherichia, Klebsiella, Salmonella, Staphylococcus_aureus, Streptococcus_agalactiae,
       Streptococcus_pneumoniae, Streptococcus_pyogenes
   HMMs: 628

Updates since release 2020-09-30.1:
   Proteins added: 23
       Core proteins added: 18
       Plus proteins added: 2
   AMR proteins added: 18
   VIRULENCE proteins added: 2
   Alleles added: 55
   Point mutations added: 43
   Protiens removed: 4
       Core proteins removed: 0
       Plus proteins removed: 4
   Reference Gene Catalog entries changed: 4
   Families added: 12
   Families removed: 4
   Families changed: 3

Added proteins
    core AMR AMR
        cml              NG_070887.1 WP_011552636.1     Cml family chloramphenicol efflux MFS transporter
        grdA             NG_070892.1 WP_052905207.1     gentamicin resistance ATP-binding protein GrdA
        cml              NG_070888.1 WP_061345584.1     Cml family chloramphenicol efflux MFS transporter
        cml              NG_070889.1 WP_115421099.1     Cml family chloramphenicol efflux MFS transporter
        gar              NG_070891.1 WP_162615879.1     gentamicin resistance ATP-binding protein Gar
        gar              NG_070890.1 WP_194293131.1     gentamicin resistance ATP-binding protein Gar
        blaAAK-1         NG_070893.1 WP_194293132.1     class A beta-lactamase AAK-1
        blaCMY-173       NG_070783.1 WP_190259774.1     class C beta-lactamase CMY-173
        blaCTX-M-242     NG_070784.1 WP_190259775.1     class A extended-spectrum beta-lactamase CTX-M-242
        blaIMI-20        NG_070894.1 WP_194293133.1     carbapenem-hydrolyzing class A beta-lactamase IMI-20
        blaKPC-71        NG_070895.1 WP_194293134.1     inhibitor-resistant class A beta-lactamase KPC-71
        blaKPC-76        NG_070896.1 WP_194293135.1     class A beta-lactamase KPC-76
        blaKPC-77        NG_070897.1 WP_194293136.1     carbapenem-hydrolyzing class A beta-lactamase KPC-77
        blaOXA-893       NG_070898.1 WP_194293137.1     OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-893
        blaOXA-930       NG_070785.1 WP_151781119.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-930
        blaOXA-931       NG_070786.1 WP_190259776.1     OXA-229 family carbapenem-hydrolyzing class D beta-lactamase OXA-931
        blaOXA-932       NG_070899.1 WP_121331722.1     OXA-10 family class D beta-lactamase OXA-932
        blaOXA-935       NG_070900.1 WP_141989064.1     OXA-10 family class D beta-lactamase OXA-935
    plus VIRULENCE VIRULENCE
        cnf3             AM263062.1 CAK19001.1          cytotoxic necrotizing factor CNF3
        cnf2             AGIA01000141.1 EID64799.1      cytotoxic necrotizing factor CNF2
Added point mutations
    core AMR POINT
        23S_A2114G       MACROLIDE Streptococcus_pneumoniae
        23S_A2115G       MACROLIDE Streptococcus_pneumoniae
        23S_A2118G       MACROLIDE/STREPTOGRAMIN Streptococcus_pneumoniae
        23S_C2630A       MACROLIDE Streptococcus_pneumoniae
        23S_C2630G       MACROLIDE Streptococcus_pneumoniae
        adeR_A91V        EFFLUX Acinetobacter_baumannii
        adeR_D20N        EFFLUX Acinetobacter_baumannii
        adeR_E219A       EFFLUX Acinetobacter_baumannii
        adeR_L192R       EFFLUX Acinetobacter_baumannii
        adeR_P116L       EFFLUX Acinetobacter_baumannii
        adeR_P56S        EFFLUX Acinetobacter_baumannii
        adeS_G336S       EFFLUX Acinetobacter_baumannii
        adeS_H189Y       EFFLUX Acinetobacter_baumannii
        adeS_I252S       EFFLUX Acinetobacter_baumannii
        adeS_N125K       EFFLUX Acinetobacter_baumannii
        adeS_Q163STOP    EFFLUX Acinetobacter_baumannii
        adeS_R152K       EFFLUX Acinetobacter_baumannii
        adeS_T153M       EFFLUX Acinetobacter_baumannii
        folP_F25I        SULFONAMIDE Streptococcus_pyogenes
        ftsI_A515V       CARBAPENEM Acinetobacter_baumannii
        gyrA_G79C        QUINOLONE Acinetobacter_baumannii
        gyrA_S81L        QUINOLONE Acinetobacter_baumannii
        parC_D83H        QUINOLONE Streptococcus_pneumoniae
        parC_E88K        QUINOLONE Acinetobacter_baumannii
        parC_S79F        QUINOLONE Streptococcus_pneumoniae
        parC_S79Y        QUINOLONE Streptococcus_pneumoniae
        parC_S84F        QUINOLONE Acinetobacter_baumannii
        parC_S84L        QUINOLONE Acinetobacter_baumannii
        parC_S84W        QUINOLONE Acinetobacter_baumannii
        pbp1a_N609D      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_S575T      BETA-LACTAM Streptococcus_pneumoniae
        pbp1a_T371S      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_E476G      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T446A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2b_T489A      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_I371T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_L546V      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M339T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_M400T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N514H      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_N605T      BETA-LACTAM Streptococcus_pneumoniae
        pbp2x_P601L      BETA-LACTAM Streptococcus_pyogenes
        pbp2x_Q557E      BETA-LACTAM Streptococcus_agalactiae
Moved proteins (sequence didn't change but have been moved from core to plus)
    Removed
        core AMR AMR
            blaEC            NG_047494.1 WP_001336292.1     BlaEC family class C beta-lactamase
            blaEC            NG_047496.1 WP_001460207.1     BlaEC family class C beta-lactamase
            blaEC            NG_047495.1 WP_063842627.1     BlaEC family class C beta-lactamase
    Replaced with
        plus AMR AMR
            blaEC            U00096.3 AAC77110.1            BlaEC family class C beta-lactamase
            blaEC            AF124202.1 AAD28042.1          BlaEC family class C beta-lactamase
            blaEC            EF507685.1 ABS58643.1          BlaEC family class C beta-lactamase
Removed proteins
    plus AMR AMR
        cprR             AE004091.2 AAG06465.1          cationic peptide response regulator transcription factor CprR
        cprS             AE004091.2 AAG06466.1          cationic peptide sensor histidine kinase CprS
        txr              AF353562.1 AAK37618.1          putative sigma-54-dependent transcription factor Txr
        arnT             FO834906.1 CDO12042.1          lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
Changed reference gene catalog records
    lmrS AAW38464.1
        class:           EFFLUX -> MACROLIDE/PHENICOL
        subclass:        EFFLUX -> ERYTHROMYCIN/CHLORAMPHENICOL
    abaF ABO11759.2
        class:           LINCOSAMIDE -> FOSFOMYCIN
        subclass:        LINCOSAMIDE -> FOSFOMYCIN
    crcB CCN31428.1
        class:           <empty> -> FLUORIDE
        subclass:        <empty> -> FLUORIDE
        subtype:         AMR -> BIOCIDE
        type:            AMR -> STRESS
    blaOXA-427 WP_096807440.1
        subclass:        BETA-LACTAM -> CARBAPENEM

Added families
    blaAAK           NF038195.1                     AAK family class A beta-lactamase
    cml              -                              Cml family chloramphenicol efflux MFS transporter
    cnf2             -                              cytotoxic necrotizing factor CNF2
    cnf3             -                              cytotoxic necrotizing factor CNF3
    estX             -                              alpha/beta fold putative hydrolase EstX
    gar              -                              gentamicin resistance ATP-binding protein Gar
    gar_fam          -                              garosamine-type aminoglycoside resistance ATP-binding protein
    grdA             -                              gentamicin resistance ATP-binding protein GrdA
    lnu(E)           NF000478.2                     lincosamide nucleotidyltransferase Lnu(E)
    tet(43)          NF012180.1                     tetracycline efflux MFS transporter Tet(43)
Removed families
    arnT             -                              lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
    cprR             -                              cationic peptide response regulator transcription factor CprR
    cprS             -                              cationic peptide sensor histidine kinase CprS
    txr              -                              putative sigma-54-dependent transcription factor Txr
Family changes
    cml              CmlA/FloR family chloramphenicol efflux MFS transporter
        gene_symbol:     bcr/cflA -> cml
    cnf              CNF1 family cytotoxic necrotizing factor
        hmm_id:          NF033651.1 -> -
    espJ             EspJ family T3SS effector ADP-ribosyltransferase
        hmm_id:          NF033643.1 -> -


----------------------------------------------------------------------
Changes included in 2020-09-30.1
----------------------------------------------------------------------

NOTE: This is a data fix release. This data release contains no new genes and
will not affect which genes are detected by AMRFinderPlus.

We are making this release because a few incomplete NG_ accessions made it
through our QC process and were included in the Reference Gene Catalog for the
previous 2020-09-22.2 release. These have no effect on AMRFinderPlus results.

No new genes have been added, but we took this opportunity to clean up the
database by removing a few families and HMMs that are not in the Reference Gene
Catalog nor used by AMRFinderPlus for element identification, but were used
internally for organization and QC purposes.

Summary:
   Total proteins: 6503
        Core proteins: 5625
        Plus proteins: 878
   AMR proteins: 5662
   STRESS proteins: 210
   VIRULENCE proteins: 631
   Point mutations: 682
   Point mutation references: 91
   Point mutation organism groups:
       Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia,
       Klebsiella, Salmonella, Staphylococcus_aureus
   HMMs: 627

Updates since release 2020-09-22.2:
   Reference Gene Catalog entries changed: 12
   Families removed: 2
   Families changed: 1

Changed reference gene catalog records
    blaLRA1 WP_063842263.1
        refseq_nucleotide_accession: NG_047484. -> NG_047484.1
    blaLRA5 WP_063842268.1
        refseq_nucleotide_accession: NG_047485. -> NG_047485.1
    blaLRA2 WP_063842701.1
        refseq_nucleotide_accession: NG_047519. -> NG_047519.1
    blaLRA3 WP_063842702.1
        refseq_nucleotide_accession: NG_047520. -> NG_047520.1
    blaLRA8 WP_063842703.1
        refseq_nucleotide_accession: NG_047521. -> NG_047521.1
    blaLRA9 WP_063842704.1
        refseq_nucleotide_accession: NG_047522. -> NG_047522.1
    blaLRA12 WP_063842707.1
        refseq_nucleotide_accession: NG_047523. -> NG_047523.1
    blaLRA17 WP_063842712.1
        refseq_nucleotide_accession: NG_047524. -> NG_047524.1
    blaLRA19 WP_063842717.1
        refseq_nucleotide_accession: NG_047525. -> NG_047525.1
    blaLRA18 WP_099982801.1
        refseq_nucleotide_accession: NG_055765. -> NG_055765.1
    blaLRA7 WP_099982802.1
        refseq_nucleotide_accession: NG_055766. -> NG_055766.1
    blaLRA10 WP_099982803.1
        refseq_nucleotide_accession: NG_055767. -> NG_055767.1

Removed families
    lnu(E)           NF000478.2                     lincosamide nucleotidyltransferase Lnu(E)
    tet(43)          NF012180.1                     tetracycline efflux MFS transporter Tet(43)
Family changes
    qnr              Qnr family pentapeptide repeat protein
        hmm_id:          NF033086.2 -> -


----------------------------------------------------------------------
Changes included in 2020-09-22.2
----------------------------------------------------------------------
Highlights:
- Addition of reference publications for  beta-lactamases
- New families for improved and finer grain organization/naming of van genes
- Improved names for blaLRA families
- mcr-9 reclassified from "core" to "plus" on the basis of Tyson et al. 2020
  (pmid: 32513803) which showed no effect on colistin phenotype in many E.
  coli and Salmonella strains
- Improved class/subclass for AAC(3)-IVa & AAC(3)-IVb
- vanX-E and vanH-E renamed to vanX-F and vanH-F
- Several new gene families

Summary:
   Total proteins: 6503
        Core proteins: 5625
        Plus proteins: 878
   AMR proteins: 5662
   STRESS proteins: 210
   VIRULENCE proteins: 631
   Point mutations: 682
   Point mutation references: 91
   Point mutation organism groups:
       Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia,
       Klebsiella, Salmonella, Staphylococcus_aureus
   HMMs: 630

Updates since release 2020-07-16.2:
   Proteins added: 75
       Core proteins added: 65
       Plus proteins added: 10
   AMR proteins added: 74
   VIRULENCE proteins added: 1
   Alleles added: 59
   Protiens removed: 0
   Reference Gene Catalog entries changed: 604
   Families added: 22
   Families removed: 0
   Families changed: 58

Added proteins
    core AMR AMR
        vanS-Sc          NG_070727.1 WP_003975349.1     VanSc-type vancomycin resistance histidine kinase VanS
        vanR-Sc          NG_070726.1 WP_011029105.1     VanSc-type vancomycin resistance response regulator transcription factor VanR
        mef(D)           NG_070723.1 WP_099483400.1     macrolide efflux MFS transporter Mef(D)
        dfrA37           NG_070720.1 WP_132586462.1     trimethoprim-resistant dihydrofolate reductase DfrA37
        msrH             NG_070725.1 WP_138070341.1     ABC-F type ribosomal protection protein Msr(H)
        dfrA39           NG_070722.1 WP_149100971.1     trimethoprim-resistant dihydrofolate reductase DfrA39
        ant(3'')-Ib      NG_070719.1 WP_149316740.1     aminoglycoside nucleotidyltransferase ANT(3'')-Ib
        aac(3)-IVb       NG_070718.1 WP_149317372.1     aminoglycoside N-acetyltransferase AAC(3)-IVb
        msrF             NG_070724.1 WP_164941513.1     ABC-F type ribosomal protection protein Msr(F)
        dfrA38           NG_070721.1 WP_188331861.1     trimethoprim-resistant dihydrofolate reductase DfrA38
        blaACC-8         NG_070728.1 WP_188331862.1     cephalosporin-hydrolyzing class C beta-lactamase ACC-8
        blaADC-236       NG_070226.1 WP_176673601.1     class C beta-lactamase ADC-236
        blaCARB-53       NG_070729.1 WP_188331863.1     PSE family carbenicillin-hydrolyzing class A beta-lactamase CARB-53
        blaCTX-M-237     NG_070730.1 WP_188331864.1     class A extended-spectrum beta-lactamase CTX-M-237
        blaCTX-M-238     NG_070731.1 WP_188331865.1     class A extended-spectrum beta-lactamase CTX-M-238
        blaCTX-M-239     NG_070732.1 WP_188331866.1     class A extended-spectrum beta-lactamase CTX-M-239
        blaCTX-M-240     NG_070733.1 WP_182496339.1     class A extended-spectrum beta-lactamase CTX-M-240
        blaCTX-M-241     NG_070734.1 WP_188331867.1     class A extended-spectrum beta-lactamase CTX-M-241
        blaGES-44        NG_070735.1 WP_188331868.1     class A beta-lactamase GES-44
        blaGES-45        NG_070736.1 WP_188331869.1     class A beta-lactamase GES-45
        blaIMP-88        NG_070737.1 WP_188331870.1     subclass B1 metallo-beta-lactamase IMP-88
        blaIMP-89        NG_070738.1 WP_181727105.1     subclass B1 metallo-beta-lactamase IMP-89
        blaKPC-66        NG_070739.1 WP_188331871.1     inhibitor-resistant class A extended-spectrum beta-lactamase KPC-66
        blaKPC-72        NG_070740.1 WP_188331872.1     inhibitor-resistant class A extended-spectrum beta-lactamase KPC-72
        blaKPC-73        NG_070741.1 WP_188331873.1     inhibitor-resistant class A extended-spectrum beta-lactamase KPC-73
        blaKPC-74        NG_070742.1 WP_188331874.1     inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-74
        blaKPC-75        NG_070743.1 WP_188331875.1     carbapenem-hydrolyzing class A beta-lactamase KPC-75
        blaLMB-1         NG_070744.1 WP_108361548.1     subclass B3 metallo-beta-lactamase LMB-1
        blaOXA-900       NG_070745.1 WP_178317675.1     class D beta-lactamase OXA-900
        blaOXA-919       NG_070746.1 WP_007879679.1     class D beta-lactamase OXA-919
        blaOXA-922       NG_070747.1 WP_188331876.1     OXA-48 family class D beta-lactamase OXA-922
        blaOXA-926       NG_070748.1 WP_114268491.1     class D beta-lactamase OXA-926
        blaOXA-928       NG_070749.1 WP_188331877.1     OXA-10 family class D beta-lactamase OXA-928
        blaOXA-929       NG_070750.1 WP_188331878.1     OXA-48 family class D beta-lactamase OXA-929
        blaPDC-453       NG_070227.1 WP_179945705.1     class C beta-lactamase PDC-453
        blaPDC-454       NG_070228.1 WP_141563014.1     class C beta-lactamase PDC-454
        blaPDC-455       NG_070229.1 WP_058135553.1     class C beta-lactamase PDC-455
        blaPDC-456       NG_070751.1 WP_188331879.1     class C beta-lactamase PDC-456
        blaPDC-457       NG_070752.1 WP_094954583.1     class C beta-lactamase PDC-457
        blaROB-10        NG_070753.1 WP_116743769.1     class A beta-lactamase ROB-10
        blaSRT-3         NG_070754.1 WP_033642964.1     class C beta-lactamase SRT-3
        blaVEB-27        NG_070755.1 WP_188331880.1     inhibitor-resistant class A extended-spectrum beta-lactamase VEB-27
        blaVIM-72        NG_070756.1 WP_188331881.1     subclass B1 metallo-beta-lactamase VIM-72
        blaVIM-73        NG_070757.1 WP_188331882.1     subclass B1 metallo-beta-lactamase VIM-73
        blaVMB-1         NG_070758.1 WP_172692932.1     subclass B1 metallo-beta-lactamase VMB-1
        blaYEM-1         NG_070759.1 WP_004874166.1     subclass B2 metallo-beta-lactamase YEM-1
        fosL1            NG_070760.1 WP_161667239.1     fosfomycin resistance glutathione transferase FosL1
        fosL2            NG_070761.1 WP_188331883.1     fosfomycin resistance glutathione transferase FosL2
        mcr-1.28         NG_070762.1 WP_181464119.1     phosphoethanolamine--lipid A transferase MCR-1.28
        mcr-1.29         NG_070763.1 WP_188331884.1     phosphoethanolamine--lipid A transferase MCR-1.29
        mcr-1.30         NG_070764.1 WP_188331885.1     phosphoethanolamine--lipid A transferase MCR-1.30
        mcr-2.4          NG_070765.1 WP_188331886.1     phosphoethanolamine--lipid A transferase MCR-2.4
        mcr-2.5          NG_070766.1 WP_188331887.1     phosphoethanolamine--lipid A transferase MCR-2.5
        mcr-2.6          NG_070767.1 WP_188331888.1     phosphoethanolamine--lipid A transferase MCR-2.6
        mcr-2.7          NG_070768.1 WP_188331889.1     phosphoethanolamine--lipid A transferase MCR-2.7
        mcr-3.31         NG_070769.1 WP_188331890.1     phosphoethanolamine--lipid A transferase MCR-3.31
        mcr-3.32         NG_070770.1 WP_188331891.1     phosphoethanolamine--lipid A transferase MCR-3.32
        mcr-3.33         NG_070771.1 WP_188331892.1     phosphoethanolamine--lipid A transferase MCR-3.33
        mcr-3.34         NG_070772.1 WP_188331893.1     phosphoethanolamine--lipid A transferase MCR-3.34
        mcr-3.35         NG_070773.1 WP_188331894.1     phosphoethanolamine--lipid A transferase MCR-3.35
        mcr-3.36         NG_070774.1 WP_188331895.1     phosphoethanolamine--lipid A transferase MCR-3.36
        mcr-3.37         NG_070775.1 WP_188331896.1     phosphoethanolamine--lipid A transferase MCR-3.37
        mcr-3.38         NG_070776.1 WP_039039919.1     phosphoethanolamine--lipid A transferase MCR-3.38
        mcr-3.39         NG_070777.1 WP_114500971.1     phosphoethanolamine--lipid A transferase MCR-3.39
        mcr-3.40         NG_070778.1 WP_188331897.1     phosphoethanolamine--lipid A transferase MCR-3.40
        qnrA11           NG_070779.1 WP_188331898.1     quinolone resistance pentapeptide repeat protein QnrA11
        qnrA12           NG_070780.1 WP_188331899.1     quinolone resistance pentapeptide repeat protein QnrA12
    plus AMR AMR
        cprR             AE004091.2 AAG06465.1          cationic peptide response regulator transcription factor CprR
        cprS             AE004091.2 AAG06466.1          cationic peptide sensor histidine kinase CprS
        txr              AF353562.1 AAK37618.1          putative sigma-54-dependent transcription factor Txr
        ranA             CP002562.1 ADZ12699.1          multidrug efflux ABC transporter ATP-binding subunit RanA
        ranB             CP002562.1 ADZ12700.1          multidrug efflux ABC transporter permease subunit RanB
        crcB             HF536482.1 CCN31428.1          fluoride efflux transporter CrcB
        arnT             FO834906.1 CDO12042.1          lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
        mcr-9.1          MK070339.1 AYW01299.1          phosphoethanolamine--lipid A transferase MCR-9.1
        mcr-9.3          MT505326.1 QKF95689.1          phosphoethanolamine--lipid A transferase MCR-9.3
    plus VIRULENCE VIRULENCE
        sinH             AE006468.2 AAL21411.1          intimin-like inverse autotransporter SinH
Removed proteins
    core AMR AMR
        mcr-9.1          NG_064792.1 WP_001572373.1     phosphoethanolamine--lipid A transferase MCR-9.1
        mcr-9.3          NG_070224.1 WP_179284395.1     phosphoethanolamine--lipid A transferase MCR-9.3
Changed reference gene catalog records
    abaF ABO11759.2
        class:           <empty> -> LINCOSAMIDE
        subclass:        <empty> -> LINCOSAMIDE
    lmrC ABX00624.1
        class:           <empty> -> FOSFOMYCIN
        subclass:        <empty> -> FOSFOMYCIN
    aac(3)-IVa WP_001199192.1
        pubmed_reference: <empty> -> 15231771
        subclass:        GENTAMICIN -> APRAMYCIN/GENTAMICIN/TOBRAMYCIN
    vanR-A WP_001280781.1
        gene_family:     vanR -> vanR-A
    vanS-A WP_002305818.1
        gene_family:     vanS -> vanS-A
    vanR-B WP_002317273.1
        gene_family:     vanR -> vanR-B
    vanW-B WP_002368694.1
        gene_family:     vanW -> vanW-B
    vanS-B WP_002368696.1
        gene_family:     vanS -> vanS-B
    vanR-B WP_002368697.1
        gene_family:     vanR -> vanR-B
    vanS-B WP_002382867.1
        gene_family:     vanS -> vanS-B
    vanR-C WP_003126775.1
        gene_family:     vanR -> vanR-C
    vanT-C WP_003126777.1
        gene_family:     vanT -> vanT-C
    vanR-Cd WP_003436401.1
        gene_family:     vanR -> vanR-Cd
        product_name:    VanG-Cd-type vancomycin resistance DNA-binding response regulator VanS -> VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
    vanR-C WP_005228837.1
        gene_family:     vanR -> vanR-C
    vanW-I WP_005813024.1
        gene_family:     vanWI -> vanW-I
        product_name:    glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-I
    vanR-F WP_006285581.1
        gene_family:     vanR -> vanR-F
    vanS-F WP_006285582.1
        gene_family:     vanS -> vanS-F
    vanH-F WP_006285586.1
        gene_family:     vanH-E -> vanH-F
        product_name:    D-lactate dehydrogenase VanH-E -> D-lactate dehydrogenase VanH-F
    vanX-F WP_006285588.1
        gene_family:     vanX-E -> vanX-F
        product_name:    D-Ala-D-Ala dipeptidase VanX-E -> D-Ala-D-Ala dipeptidase VanX-F
    vanW-B WP_010815683.1
        gene_family:     vanW -> vanW-B
    vanR-I WP_011461303.1
        gene_family:     vanR -> vanR-I
    vanK-I WP_011461306.1
        gene_family:     vanKI -> vanK-I
    vanS-Cd WP_011861275.1
        gene_family:     vanS -> vanS-Cd
    vanS-B WP_012579101.1
        gene_family:     vanS -> vanS-B
    vanX-I WP_015943580.1
        gene_family:     vanXI -> vanX-I
    vanR-D WP_016295750.1
        gene_family:     vanR -> vanR-D
    vanT-G WP_021418922.1
        gene_family:     vanT -> vanT-G
    vanS-G WP_021418927.1
        gene_family:     vanS -> vanS-G
    vanR-G WP_021418928.1
        gene_family:     vanR -> vanR-G
    vanU-G WP_021418929.1
        gene_family:     vanU -> vanU-G
        product_name:    glycopeptide resistance transcriptional regulator VanU -> glycopeptide resistance transcriptional regulator VanU-G
    vanW-G WP_021419095.1
        gene_family:     vanW -> vanW-G
    vanS-D WP_023042297.1
        gene_family:     vanS -> vanS-D
    vanR-D WP_023042613.1
        gene_family:     vanR -> vanR-D
    vanR-D WP_023043165.1
        gene_family:     vanR -> vanR-D
    vanS-D WP_028530133.1
        gene_family:     vanS -> vanS-D
    vanR-B WP_032489743.1
        gene_family:     vanR -> vanR-B
    vanW-B WP_032489744.1
        gene_family:     vanW -> vanW-B
    vanS-C WP_034869172.1
        gene_family:     vanS -> vanS-C
    vanR-C WP_034872470.1
        gene_family:     vanR -> vanR-C
    erm(30) WP_055641627.1
        subclass:        ERYTHROMYCIN -> MACROLIDE
    blaLRA1 WP_063842263.1
        gene_family:     bla -> blaLRA1
        product_name:    class A beta-lactamase LRA-1 -> LRA1 family class A beta-lactamase
        refseq_nucleotide_accession: NG_047484.1 -> NG_047484.
    blaLRA5 WP_063842268.1
        gene_family:     bla -> blaLRA5
        product_name:    class A beta-lactamase LRA-5 -> LRA5 family class A beta-lactamase
        refseq_nucleotide_accession: NG_047485.1 -> NG_047485.
    blaLRA2 WP_063842701.1
        gene_family:     blaLRA -> blaLRA2
        product_name:    subclass B3 metallo-beta-lactamase LRA-2 -> LRA2 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047519.1 -> NG_047519.
    blaLRA3 WP_063842702.1
        gene_family:     blaLRA -> blaLRA3
        product_name:    subclass B3 metallo-beta-lactamase LRA-3 -> LRA3 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047520.1 -> NG_047520.
    blaLRA8 WP_063842703.1
        gene_family:     blaLRA -> blaLRA8
        product_name:    subclass B3 metallo-beta-lactamase LRA-8 -> LRA8 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047521.1 -> NG_047521.
    blaLRA9 WP_063842704.1
        gene_family:     blaLRA -> blaLRA9
        product_name:    subclass B3 metallo-beta-lactamase LRA-9 -> LRA9 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047522.1 -> NG_047522.
    blaLRA12 WP_063842707.1
        gene_family:     blaLRA -> blaLRA12
        product_name:    subclass B3 metallo-beta-lactamase LRA-12 -> LRA12 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047523.1 -> NG_047523.
    blaLRA17 WP_063842712.1
        gene_family:     blaLRA -> blaLRA17
        product_name:    subclass B3 metallo-beta-lactamase LRA-17 -> LRA17 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047524.1 -> NG_047524.
    blaLRA19 WP_063842717.1
        gene_family:     blaLRA -> blaLRA19
        product_name:    subclass B3 metallo-beta-lactamase LRA-19 -> LRA19 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_047525.1 -> NG_047525.
    erm(31) WP_063844492.1
        subclass:        ERYTHROMYCIN -> MACROLIDE
    vanR-D WP_063856715.1
        gene_family:     vanR -> vanR-D
    vanR-A WP_063856716.1
        gene_family:     vanR -> vanR-A
    vanR-E WP_063856718.1
        gene_family:     vanR -> vanR-E
    vanR-B WP_063856719.1
        gene_family:     vanR -> vanR-B
    vanR-A WP_063856720.1
        gene_family:     vanR -> vanR-A
    vanR-A WP_063856721.1
        gene_family:     vanR -> vanR-A
    vanR-D WP_063856722.1
        gene_family:     vanR -> vanR-D
    vanR-B WP_063856723.1
        gene_family:     vanR -> vanR-B
    vanR-L WP_063856724.1
        gene_family:     vanR -> vanR-L
    vanR-C WP_063856725.1
        gene_family:     vanR -> vanR-C
    vanR-M WP_063856726.1
        gene_family:     vanR -> vanR-M
    vanR-D WP_063856727.1
        gene_family:     vanR -> vanR-D
    vanR-N WP_063856728.1
        gene_family:     vanR -> vanR-N
    vanR-O WP_063856729.1
        gene_family:     vanR -> vanR-O
    vanS-D WP_063856730.1
        gene_family:     vanS -> vanS-D
    vanS-A WP_063856731.1
        gene_family:     vanS -> vanS-A
    vanS-G WP_063856732.1
        gene_family:     vanS -> vanS-G
    vanS-C WP_063856733.1
        gene_family:     vanS -> vanS-C
    vanS-E WP_063856734.1
        gene_family:     vanS -> vanS-E
    vanS-D WP_063856738.1
        gene_family:     vanS -> vanS-D
    vanS-B WP_063856739.1
        gene_family:     vanS -> vanS-B
    vanS-Pt2 WP_063856740.1
        gene_family:     vanS -> vanS-Pt2
    vanS-Pt WP_063856741.1
        gene_family:     vanS -> vanS-Pt
    vanS-Pt WP_063856742.1
        gene_family:     vanS -> vanS-Pt
    vanS-C WP_063856743.1
        gene_family:     vanS -> vanS-C
    vanS-D WP_063856744.1
        gene_family:     vanS -> vanS-D
    vanS-L WP_063856745.1
        gene_family:     vanS -> vanS-L
    vanS-M WP_063856748.1
        gene_family:     vanS -> vanS-M
    vanS-N WP_063856749.1
        gene_family:     vanS -> vanS-N
    vanS-B WP_063856751.1
        gene_family:     vanS -> vanS-B
    vanT-G WP_063856752.1
        gene_family:     vanT -> vanT-G
    vanT-E WP_063856753.1
        gene_family:     vanT -> vanT-E
    vanT-C WP_063856754.1
        gene_family:     vanT -> vanT-C
    vanT-C WP_063856755.1
        gene_family:     vanT -> vanT-C
    vanT-C WP_063856756.1
        gene_family:     vanT -> vanT-C
    vanT-N WP_063856757.1
        gene_family:     vanT -> vanT-N
    vanW-G WP_063856762.1
        gene_family:     vanW -> vanW-G
    vanW-B WP_063856763.1
        gene_family:     vanW -> vanW-B
    vanW-Pt WP_063856764.1
        gene_family:     vanW -> vanW-Pt
        product_name:    glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-Pt
    vanW-B WP_063856765.1
        gene_family:     vanW -> vanW-B
    vanW-B WP_063856766.1
        gene_family:     vanW -> vanW-B
    vanS-O WP_070064533.1
        gene_family:     vanS -> vanS-O
    vanT-Cd WP_071593222.1
        gene_family:     vanT -> vanT-Cd
    blaLRA18 WP_099982801.1
        product_name:    LRA-18 family class C beta-lactamase -> LRA18 family class C beta-lactamase
        refseq_nucleotide_accession: NG_055765.1 -> NG_055765.
    blaLRA7 WP_099982802.1
        gene_family:     blaLRA -> blaLRA7
        product_name:    subclass B3 metallo-beta-lactamase LRA-7 -> LRA7 family subclass B3 metallo-beta-lactamase
        refseq_nucleotide_accession: NG_055766.1 -> NG_055766.
    blaLRA10 WP_099982803.1
        product_name:    LRA-10 family class C beta-lactamase -> LRA10 family class C beta-lactamase
        refseq_nucleotide_accession: NG_055767.1 -> NG_055767.
    blaACC-1 WP_032491956.1
        pubmed_reference: <empty> -> 10428914
    blaACC-2 WP_063857702.1
        pubmed_reference: <empty> -> 10817695
    blaACC-4 WP_063857708.1
        pubmed_reference: <empty> -> 17664321
    blaACC-5 WP_063857715.1
        pubmed_reference: <empty> -> 24267783
    blaACT-1 WP_063857727.1
        pubmed_reference: <empty> -> 9055993
    blaACT-10 WP_063857730.1
        pubmed_reference: <empty> -> 25312010
    blaACT-12 WP_025206265.1
        pubmed_reference: <empty> -> 25501887
    blaACT-14 WP_063138000.1
        pubmed_reference: <empty> -> 25501887
    blaACT-15 WP_023295792.1
        pubmed_reference: <empty> -> 25501887
    blaACT-16 WP_023315250.1
        pubmed_reference: <empty> -> 24336426
    blaACT-17 WP_017694683.1
        pubmed_reference: <empty> -> 25501887
    blaACT-18 WP_063857768.1
        pubmed_reference: <empty> -> 25501887
    blaACT-19 WP_047354536.1
        pubmed_reference: <empty> -> 25501887
    blaACT-22 WP_063857771.1
        pubmed_reference: <empty> -> 25501887
    blaACT-23 WP_045620946.1
        pubmed_reference: <empty> -> 24629772
    blaACT-3 WP_063857773.1
        pubmed_reference: <empty> -> 18789849
    blaACT-9 WP_013981172.1
        pubmed_reference: <empty> -> 21690276
    blaBEL-1 WP_063857830.1
        pubmed_reference: <empty> -> 16127048
    blaBEL-2 WP_063857831.1
        pubmed_reference: <empty> -> 19884378
    blaBEL-3 WP_063857832.1
        pubmed_reference: <empty> -> 19933793
    blaCARB-1 WP_063857835.1
        pubmed_reference: <empty> -> 377324, 11959558
    blaCARB-10 WP_063857836.1
        pubmed_reference: <empty> -> 19380596
    blaCARB-14 WP_063857843.1
        pubmed_reference: <empty> -> 22633451
    blaCARB-17 WP_023624728.1
        pubmed_reference: <empty> -> 25801555
    blaCARB-2 WP_001931474.1
        pubmed_reference: <empty> -> 377324, 410783, 1804019
    blaCARB-4 WP_032489168.1
        pubmed_reference: <empty> -> 3087285, 9687391
    blaCARB-5 WP_063859341.1
        pubmed_reference: <empty> -> 2786828, 10722515
    blaCARB-6 WP_063859348.1
        pubmed_reference: <empty> -> 9925522
    blaCARB-7 WP_029628776.1
        pubmed_reference: <empty> -> 12069969
    blaCARB-8 WP_063859363.1
        pubmed_reference: <empty> -> 12709319
    blaCARB-9 WP_002022164.1
        pubmed_reference: <empty> -> 15388476
    blaCFE-1 WP_032490699.1
        pubmed_reference: <empty> -> 15047515
    blaCMY-1 WP_032488864.1
        pubmed_reference: <empty> -> 8843306
    blaCMY-10 WP_032492452.1
        pubmed_reference: <empty> -> 12969288
    blaCMY-107 WP_032494240.1
        pubmed_reference: <empty> -> 26438499
    blaCMY-108 WP_063859673.1
        pubmed_reference: <empty> -> 24500191
    blaCMY-11 WP_032492458.1
        pubmed_reference: <empty> -> 11815567
    blaCMY-110 WP_063859688.1
        pubmed_reference: <empty> -> 24709044
    blaCMY-12 WP_063859743.1
        pubmed_reference: <empty> -> 12407124
    blaCMY-13 WP_020996270.1
        pubmed_reference: <empty> -> 15273143
    blaCMY-14 WP_063859816.1
        pubmed_reference: <empty> -> 15504832
    blaCMY-15 WP_063859817.1
        pubmed_reference: <empty> -> 15504832
    blaCMY-16 WP_014386387.1
        pubmed_reference: <empty> -> 16436718
    blaCMY-18 WP_063859824.1
        pubmed_reference: <empty> -> 16584308
    blaCMY-19 WP_063859826.1
        pubmed_reference: <empty> -> 16436707
    blaCMY-2 WP_000976514.1
        pubmed_reference: <empty> -> 8787910
    blaCMY-20 WP_063859827.1
        pubmed_reference: <empty> -> 18207348
    blaCMY-21 WP_063859828.1
        pubmed_reference: <empty> -> 16716570
    blaCMY-23 WP_000976515.1
        pubmed_reference: <empty> -> 17110393
    blaCMY-24 WP_032491928.1
        pubmed_reference: <empty> -> 17587551
    blaCMY-25 WP_003830525.1
        pubmed_reference: <empty> -> 19523051
    blaCMY-26 WP_063859830.1
        pubmed_reference: <empty> -> 17720829
    blaCMY-27 WP_063859831.1
        pubmed_reference: <empty> -> 19523051
    blaCMY-29 WP_063859833.1
        pubmed_reference: <empty> -> 19414570
    blaCMY-30 WP_000976513.1
        pubmed_reference: <empty> -> 19414570
    blaCMY-31 WP_012262157.1
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        pubmed_reference: <empty> -> 11557480
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        pubmed_reference: <empty> -> 14613945
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        pubmed_reference: <empty> -> 15047521
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        pubmed_reference: <empty> -> 15650379
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        pubmed_reference: <empty> -> 8067742
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        pubmed_reference: <empty> -> 9925535
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        pubmed_reference: <empty> -> 9925535
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        pubmed_reference: <empty> -> 15855509
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    blaVEB-24 WP_156404663.1
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    vanS-B-Delta WP_063856737.1
        gene_family:     vanS -> vanS-B

Added families
    aac(3)-IVb       -                              aminoglycoside N-acetyltransferase AAC(3)-IVb
    ant(3'')-Ib      -                              aminoglycoside nucleotidyltransferase ANT(3'')-Ib
    arnT             -                              lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
    blaLMB           -                              LMB family subclass B3 metallo-beta-lactamase
    blaOXA           NF038183.1                     OXA-919 family class D beta-lactamase
    blaVMB           NF038184.1                     VMB family subclass B1 metallo-beta-lactamase
    blaYEM           NF038166.1                     YEM family subclass B2 metallo-beta-lactamase
    cprR             -                              cationic peptide response regulator transcription factor CprR
    cprS             -                              cationic peptide sensor histidine kinase CprS
    crcB             -                              fluoride efflux transporter CrcB
    dfrA37           -                              trimethoprim-resistant dihydrofolate reductase DfrA37
    dfrA38           -                              trimethoprim-resistant dihydrofolate reductase DfrA38
    dfrA39           -                              trimethoprim-resistant dihydrofolate reductase DfrA39
    fos              NF033405.1                     fosfomycin resistance glutathione transferase FosLL
    mef(D)           -                              macrolide efflux MFS transporter Mef(D)
    msrF             -                              ABC-F type ribosomal protection protein Msr(F)
    msrH             -                              ABC-F type ribosomal protection protein Msr(H)
    ranA             -                              multidrug efflux ABC transporter ATP-binding subunit RanA
    ranB             -                              multidrug efflux ABC transporter permease subunit RanB
    txr              -                              putative sigma-54-dependent transcription factor Txr
    vanR-Sc          -                              VanSc-type vancomycin resistance response regulator transcription factor VanR
    vanS-Sc          -                              VanSc-type vancomycin resistance histidine kinase VanS
Family changes
    blaLRA1          LRA1 family class A beta-lactamase
        gene_symbol:     bla -> blaLRA1
        family_name:     class A beta-lactamase LRA-1 -> LRA1 family class A beta-lactamase
    blaLRA10         LRA10 family class C beta-lactamase
        family_name:     LRA-10 family class C beta-lactamase -> LRA10 family class C beta-lactamase
    blaLRA12         LRA12 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA12
        family_name:     subclass B3 metallo-beta-lactamase LRA-12 -> LRA12 family subclass B3 metallo-beta-lactamase
    blaLRA           LRA12 family subclass B3 metallo-beta-lactamase
        family_name:     LRA-12 family subclass B3 metallo-beta-lactamase -> LRA12 family subclass B3 metallo-beta-lactamase
    blaLRA13         LRA13 family bifunctional class D/class C beta-lactamase
        gene_symbol:     ampC -> blaLRA13
        family_name:     bifunctional class D/class C beta-lactamase LRA-13 -> LRA13 family bifunctional class D/class C beta-lactamase
    blaLRA17         LRA17 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA17
        family_name:     subclass B3 metallo-beta-lactamase LRA-17 -> LRA17 family subclass B3 metallo-beta-lactamase
    blaLRA18         LRA18 family class C beta-lactamase
        family_name:     LRA-18 family class C beta-lactamase -> LRA18 family class C beta-lactamase
    blaLRA19         LRA19 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA19
        family_name:     subclass B3 metallo-beta-lactamase LRA-19 -> LRA19 family subclass B3 metallo-beta-lactamase
    blaLRA2          LRA2 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA2
        family_name:     subclass B3 metallo-beta-lactamase LRA-2 -> LRA2 family subclass B3 metallo-beta-lactamase
    blaLRA           LRA2 family subclass B3 metallo-beta-lactamase
        family_name:     LRA-2 family subclass B3 metallo-beta-lactamase -> LRA2 family subclass B3 metallo-beta-lactamase
    blaLRA3          LRA3 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA3
        family_name:     subclass B3 metallo-beta-lactamase LRA-3 -> LRA3 family subclass B3 metallo-beta-lactamase
    blaLRA           LRA3 family subclass B3 metallo-beta-lactamase
        family_name:     LRA-3 family subclass B3 metallo-beta-lactamase -> LRA3 family subclass B3 metallo-beta-lactamase
    blaLRA5          LRA5 family class A beta-lactamase
        gene_symbol:     bla -> blaLRA5
        family_name:     class A beta-lactamase LRA-5 -> LRA5 family class A beta-lactamase
    blaLRA7          LRA7 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA7
        family_name:     subclass B3 metallo-beta-lactamase LRA-7 -> LRA7 family subclass B3 metallo-beta-lactamase
    blaLRA8          LRA8 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA8
        family_name:     subclass B3 metallo-beta-lactamase LRA-8 -> LRA8 family subclass B3 metallo-beta-lactamase
    blaLRA9          LRA9 family subclass B3 metallo-beta-lactamase
        gene_symbol:     blaLRA -> blaLRA9
        family_name:     subclass B3 metallo-beta-lactamase LRA-9 -> LRA9 family subclass B3 metallo-beta-lactamase
    fosL             fosfomycin resistance glutathione transferase FosL
        gene_symbol:     fos -> fosL
        hmm_id:          NF033405.1 -> -
    vanK-I           peptidoglycan bridge formation peptidyltransferase VanK-I
        gene_symbol:     vanKI -> vanK-I
    vanR-A           VanA-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-A
    vanR-B           VanB-type vancomycin resistance response regulator transcription factor VanR
        gene_symbol:     vanR -> vanR-B
    vanR-C           VanC-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-C
    vanR-Cd          VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-Cd
        family_name:     VanG-Cd-type vancomycin resistance DNA-binding response regulator VanS -> VanG-Cd-type vancomycin resistance DNA-binding response regulator VanR
    vanR-D           VanD-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-D
    vanR-E           VanE-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-E
    vanR-F           VanF-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-F
    vanR-G           VanG-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-G
    vanR-I           VanI-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-I
    vanR-L           VanL-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-L
    vanR-M           VanM-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-M
    vanR-N           VanN-type vancomycin resistance DNA-binding response regulator VanR
        gene_symbol:     vanR -> vanR-N
    vanR-O           VanO-type vancomycin resistance response regulator transcription factor VanR
        gene_symbol:     vanR -> vanR-O
    vanS-A           VanA-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-A
    vanS-B           VanB-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-B
    vanS-C           VanC-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-C
    vanS-Cd          VanG-Cd-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-Cd
    vanS-D           VanD-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-D
    vanS-E           VanE-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-E
    vanS-F           VanF-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-F
    vanS-G           VanG-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-G
    vanS-L           VanL-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-L
    vanS-M           VanM-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-M
    vanS-N           VanN-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-N
    vanS-O           VanO-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-O
    vanS-Pt          VanPt-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-Pt
    vanS-Pt2         VanPt2-type vancomycin resistance histidine kinase VanS
        gene_symbol:     vanS -> vanS-Pt2
    vanT-C           membrane-bound serine racemase VanT-C
        gene_symbol:     vanT -> vanT-C
    vanT-Cd          membrane-bound serine racemase VanT-Cd
        gene_symbol:     vanT -> vanT-Cd
    vanT-E           membrane-bound serine racemase VanT-E
        gene_symbol:     vanT -> vanT-E
    vanT-G           membrane-bound serine racemase VanT-G
        gene_symbol:     vanT -> vanT-G
    vanT-N           membrane-bound serine racemase VanT-N
        gene_symbol:     vanT -> vanT-N
    vanU-G           glycopeptide resistance transcriptional regulator VanU-G
        gene_symbol:     vanU -> vanU-G
        family_name:     glycopeptide resistance transcriptional regulator VanU -> glycopeptide resistance transcriptional regulator VanU-G
    vanW-B           glycopeptide resistance accessory protein VanW-B
        gene_symbol:     vanW -> vanW-B
    vanW-G           glycopeptide resistance accessory protein VanW-G
        gene_symbol:     vanW -> vanW-G
    vanW-I           glycopeptide resistance accessory protein VanW-I
        gene_symbol:     vanWI -> vanW-I
        family_name:     glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-I
    vanW-Pt          glycopeptide resistance accessory protein VanW-Pt
        gene_symbol:     vanW -> vanW-Pt
        family_name:     glycopeptide resistance accessory protein VanW -> glycopeptide resistance accessory protein VanW-Pt
    vanX-I           D-Ala-D-Ala dipeptidase VanX-I
        gene_symbol:     vanXI -> vanX-I

----------------------------------------------------------------------
Changes included in 2020-07-16.2
----------------------------------------------------------------------
Highlights:
- Users should beware that the literature occasionally provides identical or
  highly similar gene symbols for unrelated proteins. streptothricin
  N-acetyltransferases have gene symbols sat2, sat3, etc., while sat as a
  three-letter gene symbol (changed to match the literature in this release
  "auto-sat" in previous releases), refers specifically to the serine
  protease autotransporter toxin Sat.
- Added some more specific symbols for already included AME genes
- Corrected the class and subclass for smr
- 50 new alleles and 1 new AMR gene

Summary:
   Total proteins: 6428
        Core proteins: 5560
        Plus proteins: 868
   AMR proteins: 5588
   STRESS proteins: 210
   VIRULENCE proteins: 630
   Point mutations: 682
   Point mutation references: 91
   Point mutation organism groups:
       Campylobacter, Enterococcus_faecalis, Enterococcus_faecium, Escherichia,
       Klebsiella, Salmonella, Staphylococcus_aureus
HMMs: 1574

Updates since release 2020-06-11.1:
   Proteins added: 52
       Core proteins added: 52
       Plus proteins added: 0
   AMR proteins added: 52
   Alleles added: 51
   Reference Gene Catalog entries changed: 8
   Families added: 4
   Families changed: 2

Added proteins
    core AMR AMR
        cfr(E)           NG_070225.1 WP_105119688.1     23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(E)
        blaACT-87        NG_070175.1 WP_121527365.1     cephalosporin-hydrolyzing class C beta-lactamase ACT-87
        blaCARB-54       NG_070176.1 WP_179284317.1     RTG family carbenicillin-hydrolyzing class A beta-lactamase CARB-54
        blaKPC-58        NG_070177.1 WP_179284320.1     inhibitor-resistant class A beta-lactamase KPC-58
        blaKPC-59        NG_070178.1 WP_179284322.1     carbapenem-hydrolyzing class A beta-lactamase KPC-59
        blaKPC-60        NG_070179.1 WP_179284324.1     carbapenem-hydrolyzing class A beta-lactamase KPC-60
        blaKPC-61        NG_070180.1 WP_179284328.1     carbapenem-hydrolyzing class A beta-lactamase KPC-61
        blaOXA-917       NG_070181.1 WP_161507793.1     class D beta-lactamase OXA-917
        blaOXA-918       NG_070182.1 WP_179284333.1     OXA-48 family class D beta-lactamase OXA-918
        blaOXA-920       NG_070183.1 WP_179284336.1     OXA-48 family class D beta-lactamase OXA-920
        blaOXA-921       NG_070184.1 WP_179284339.1     OXA-1 family class D beta-lactamase OXA-921
        blaOXA-923       NG_070185.1 WP_179284342.1     OXA-48 family class D beta-lactamase OXA-923
        blaOXA-924       NG_070186.1 WP_179284345.1     OXA-48 family class D beta-lactamase OXA-924
        blaOXA-925       NG_070187.1 WP_100507493.1     class D beta-lactamase OXA-925
        blaPDC-422       NG_070188.1 WP_179284354.1     class C beta-lactamase PDC-422
        blaPDC-423       NG_070189.1 WP_134600670.1     class C beta-lactamase PDC-423
        blaPDC-424       NG_070190.1 WP_179284357.1     class C beta-lactamase PDC-424
        blaPDC-425       NG_070191.1 WP_179284360.1     class C beta-lactamase PDC-425
        blaPDC-426       NG_070192.1 WP_179284362.1     class C beta-lactamase PDC-426
        blaPDC-427       NG_070193.1 WP_179284365.1     class C beta-lactamase PDC-427
        blaPDC-428       NG_070194.1 WP_179284368.1     class C beta-lactamase PDC-428
        blaPDC-429       NG_070195.1 WP_179284370.1     class C beta-lactamase PDC-429
        blaPDC-430       NG_070196.1 WP_179284371.1     class C beta-lactamase PDC-430
        blaPDC-431       NG_070197.1 WP_023118898.1     class C beta-lactamase PDC-431
        blaPDC-432       NG_070198.1 WP_179284372.1     class C beta-lactamase PDC-432
        blaPDC-433       NG_070199.1 WP_133452685.1     class C beta-lactamase PDC-433
        blaPDC-434       NG_070200.1 WP_179284373.1     class C beta-lactamase PDC-434
        blaPDC-435       NG_070201.1 WP_179284374.1     class C beta-lactamase PDC-435
        blaPDC-436       NG_070202.1 WP_179284375.1     class C beta-lactamase PDC-436
        blaPDC-437       NG_070203.1 WP_179284376.1     class C beta-lactamase PDC-437
        blaPDC-438       NG_070204.1 WP_179284377.1     class C beta-lactamase PDC-438
        blaPDC-439       NG_070205.1 WP_179284378.1     class C beta-lactamase PDC-439
        blaPDC-440       NG_070206.1 WP_179284379.1     class C beta-lactamase PDC-440
        blaPDC-441       NG_070207.1 WP_179284380.1     class C beta-lactamase PDC-441
        blaPDC-442       NG_070208.1 WP_049305288.1     class C beta-lactamase PDC-442
        blaPDC-443       NG_070209.1 WP_132710363.1     class C beta-lactamase PDC-443
        blaPDC-444       NG_070210.1 WP_179284381.1     class C beta-lactamase PDC-444
        blaPDC-445       NG_070211.1 WP_179284382.1     class C beta-lactamase PDC-445
        blaPDC-446       NG_070212.1 WP_179284383.1     class C beta-lactamase PDC-446
        blaPDC-447       NG_070213.1 WP_179284384.1     class C beta-lactamase PDC-447
        blaPDC-448       NG_070214.1 WP_179284385.1     class C beta-lactamase PDC-448
        blaPDC-449       NG_070215.1 WP_179284386.1     class C beta-lactamase PDC-449
        blaPDC-450       NG_070216.1 WP_179284387.1     class C beta-lactamase PDC-450
        blaPDC-451       NG_070217.1 WP_179284388.1     class C beta-lactamase PDC-451
        blaPDC-452       NG_070218.1 WP_179284389.1     class C beta-lactamase PDC-452
        blaROB-6         NG_070219.1 WP_179284390.1     class A beta-lactamase ROB-6
        blaROB-7         NG_070220.1 WP_179284391.1     class A beta-lactamase ROB-7
        blaROB-8         NG_070221.1 WP_179284392.1     class A beta-lactamase ROB-8
        blaTEM-228       NG_068038.1 WP_164461302.1     class A beta-lactamase TEM-228
        blaVEB-26        NG_070222.1 WP_179284393.1     class A extended-spectrum beta-lactamase VEB-26
        blaVIM-71        NG_070223.1 WP_179284394.1     subclass B1 metallo-beta-lactamase VIM-71
        mcr-9.3          NG_070224.1 WP_179284395.1     phosphoethanolamine--lipid A transferase MCR-9.3
Changed reference gene catalog records
    sat AFK88558.1
        gene_family:     auto-sat -> sat
    sat CAE55775.1
        gene_family:     auto-sat -> sat
    aac(3)-IIg WP_012695485.1
        gene_family:     aac(3)-II -> aac(3)-IIg
        product_name:    AAC(3)-II family aminoglycoside N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-IIg
    aph(3')-VIIIb WP_016656536.1
        gene_family:     aph(3')-VIII -> aph(3')-VIIIb
        product_name:    aminoglycoside O-phosphotransferase APH(3')-VIII -> aminoglycoside O-phosphotransferase APH(3')-VIIIb
    aph(3')-VIIIa WP_030183523.1
        gene_family:     aph(3')-VIII -> aph(3')-VIIIa
        product_name:    aminoglycoside O-phosphotransferase APH(3')-VIII -> aminoglycoside O-phosphotransferase APH(3')-VIIIa
    smr WP_032491400.1
        class:           MULTIDRUG -> QUATERNARY AMMONIUM
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM
    smr WP_063854743.1
        class:           MULTIDRUG -> QUATERNARY AMMONIUM
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM
    smr WP_071846258.1
        class:           MULTIDRUG -> QUATERNARY AMMONIUM
        subclass:        AMPICILLIN/CHLORAMPHENICOL/QUINOLONE/RIFAMPIN/TETRACYCLINE -> QUATERNARY AMMONIUM

Added families
    aac(3)-IIg       -                              aminoglycoside N-acetyltransferase AAC(3)-IIg
    aph(3')-VIIIa    -                              aminoglycoside O-phosphotransferase APH(3')-VIIIa
    aph(3')-VIIIb    -                              aminoglycoside O-phosphotransferase APH(3')-VIIIb
    cfr(E)           -                              23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(E)
Family changes
    bla              BKC/GPC family carbapenem-hydrolyzing class A beta-lactamase
        hmm_id:          NF033626.1 -> NF033626.2
    sat              serine protease autotransporter toxin Sat
        gene_symbol:     auto-sat -> sat


----------------------------------------------------------------------
Changes included in 2020-06-11.1
----------------------------------------------------------------------
Highlights:
- Changed the format of the change log below to hopefully make relevant
        information clearer
- Added Staphylococcus aureus AMR point mutations
- Added aac(6')-III, a new gene family with HMM and proteins
- Cleanup of the GenBank protein accessions and curated_refseq_start fields
    of the Reference Gene Catalog
        - Removed GenBank Protein accessions where the start sites don't
        match the curated start sites
        - Changed curated_refseq_start from 'Yes' to 'No' where the protein
        accession points at sequence identical to the refseq protein accession
- Some new beta-lactamase alleles

Summary counts:
Total proteins: 6,376
    Core proteins: 5,508
    Plus proteins: 868
Point mutations: 682
AMR proteins: 5,536
STRESS proteins: 210
VIRULENCE proteins: 630

Updates since release 2020-05-04.1:
    Genes added: 10
        Core genes added: 10
        Plus genes added: 0
    Sequences replaced: 1
        Core gene sequences replaced: 1
    Point mutations added: 38
    Other Reference Gene Catalog changes: 116
    Families added: 1
    Families changed: 1

Core genes added
        Added blaLEN-27       NG_068509.1 WP_008804981.1 class A beta-lactamase LEN-27
        Added aac(6')-III     NG_068500.1 WP_010107623.1 tobramycin N-acetyltransferase AAC(6')-III
        Added aac(6')-III     NG_068502.1 WP_038726674.1 tobramycin N-acetyltransferase AAC(6')-III
        Added aac(6')-III     NG_068501.1 WP_038790798.1 tobramycin N-acetyltransferase AAC(6')-III
        Added                 NG_052372.1 WP_071846307.1 bifunctional putative esterase EstX/streptothricin N-acetyltransferase Sat1
        Added blaCTX-M-236    NG_068506.1 WP_156658722.1 class A extended-spectrum beta-lactamase CTX-M-236
        Added blaBKC-2        NG_068505.1 WP_171476787.1 carbapenem-hydrolyzing class A beta-lactamase BKC-2
        Added blaKPC-50       NG_068507.1 WP_171476788.1 inhibitor-resistant class A beta-lactamase KPC-50
        Added blaKPC-57       NG_068508.1 WP_171476789.1 inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-57
        Added blaOXA-916      NG_068510.1 WP_171476790.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-916
Core gene sequences replaced
     Replaced blaB-6          NG_048700.1 WP_059345632.1 subclass B1 metallo-beta-lactamase BlaB-6
         with blaB-6          NG_068504.1 WP_068791546.1 subclass B1 metallo-beta-lactamase BlaB-6
Point mutations added
        Added 23S_A2531G      LINEZOLID Staphylococcus_aureus
        Added 23S_C2220T      LINEZOLID Staphylococcus_aureus
        Added 23S_G2475T      LINEZOLID Staphylococcus_aureus
        Added 23S_G2533A      LINEZOLID Staphylococcus_aureus
        Added 23S_G2794T      LINEZOLID Staphylococcus_aureus
        Added 23S_T2528A      LINEZOLID Staphylococcus_aureus
        Added 23S_T2532C      LINEZOLID Staphylococcus_aureus
        Added fusA_A376V      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_D373N      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_D387I      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_I449K      FUSIDIC ACID Staphylococcus_aureus
        Added fusA_V607I      FUSIDIC ACID Staphylococcus_aureus
        Added gyrA_D73G       QUINOLONE Staphylococcus_aureus
        Added gyrA_E88R       QUINOLONE Staphylococcus_aureus
        Added gyrA_G82C       QUINOLONE Staphylococcus_aureus
        Added gyrA_S84V       QUINOLONE Staphylococcus_aureus
        Added gyrB_D436N      QUINOLONE Staphylococcus_aureus
        Added gyrB_E476D      QUINOLONE Staphylococcus_aureus
        Added ileS_F563L      MUPIROCIN Staphylococcus_aureus
        Added ileS_G593V      MUPIROCIN Staphylococcus_aureus
        Added ileS_H67Q       MUPIROCIN Staphylococcus_aureus
        Added ileS_R816C      MUPIROCIN Staphylococcus_aureus
        Added parC_A116V      QUINOLONE Staphylococcus_aureus
        Added parE_D432V      QUINOLONE Staphylococcus_aureus
        Added parE_D443E      QUINOLONE Staphylococcus_aureus
        Added parE_P451S      QUINOLONE Staphylococcus_aureus
        Added parE_R444S      QUINOLONE Staphylococcus_aureus
        Added rplC_G139R      LINEZOLID Staphylococcus_aureus
        Added rplC_G152D      LINEZOLID Staphylococcus_aureus
        Added rplC_G155R      LINEZOLID Staphylococcus_aureus
        Added rplC_M169L      LINEZOLID Staphylococcus_aureus
        Added rplC_S145DEL    LINEZOLID Staphylococcus_aureus
        Added rpoB_A477G      RIFAMPIN Staphylococcus_aureus
        Added rpoB_Q468I      RIFAMPIN Staphylococcus_aureus
        Added rpoB_Q468L      RIFAMPIN Staphylococcus_aureus
        Added rpoB_Q468R      RIFAMPIN Staphylococcus_aureus
        Added rpoB_R484C      RIFAMPIN Staphylococcus_aureus
        Added rpoB_S463N      RIFAMPIN Staphylococcus_aureus
Other changes in the Reference Gene Catalog:
      Changed 16S_T1406A NC_000913.3
              class: AMINGLYCOSIDE -> AMINOGLYCOSIDE
      Changed aac(3)-VIa WP_000131886.1
              genbank_protein_accession: ABF67772.1 -> <empty>
      Changed tet(A) WP_000804063.1
              genbank_protein_accession: AAN06707.1 -> <empty>
      Changed aacA57-2 WP_000959805.1
              genbank_protein_accession: CAM88403.1 -> <empty>
      Changed qnrB6 WP_001749994.1
              genbank_protein_accession: ABP87778.1 -> <empty>
      Changed cmlA5 WP_012300772.1
              curated_refseq_start: Yes -> No
      Changed qnrB1 WP_014386481.1
              curated_refseq_start: Yes -> No
      Changed aac(3)-Ia WP_022542381.1
              genbank_protein_accession: AAB20441.1 -> <empty>
      Changed blaCARB-23 WP_025442943.1
              genbank_protein_accession: AHJ02283.1 -> <empty>
      Changed blaCARB-21 WP_025632811.1
              genbank_protein_accession: AGQ93789.1 -> <empty>
      Changed blaALI-1 WP_026025287.1
              genbank_protein_accession: CAQ78899.1 -> <empty>
      Changed dfrA25 WP_029391998.1
              genbank_protein_accession: ABB71176.1 -> <empty>
      Changed tet(31) WP_031204920.1
              genbank_protein_accession: CAC80727.1 -> <empty>
      Changed blaGOB-39 WP_031257659.1
              genbank_protein_accession: EQB91719.1 -> <empty>
      Changed aac(3)-Ia WP_032492247.1
              curated_refseq_start: Yes -> No
      Changed qnrB18 WP_032941855.1
              genbank_protein_accession: CAP45903.1 -> <empty>
      Changed qnrB30 WP_032944434.1
              genbank_protein_accession: ADM52194.1 -> <empty>
      Changed qnrB12 WP_038640920.1
              genbank_protein_accession: CAO82104.1 -> <empty>
      Changed erm(44)v WP_041079981.1
              genbank_protein_accession: CUU67654.1 -> <empty>
      Changed blaSGM-2 WP_041385949.1
              genbank_protein_accession: BAI97006.1 -> <empty>
      Changed aacA47 WP_041550454.1
              genbank_protein_accession: AFY97005.1 -> <empty>
      Changed catA13 WP_043774378.1
              genbank_protein_accession: ABO92401.1 -> <empty>
      Changed blaGOB-42 WP_047034183.1
              genbank_protein_accession: AKH95462.1 -> <empty>
      Changed qnrB3 WP_047731800.1
              curated_refseq_start: Yes -> No
      Changed erm(42) WP_052259183.1
              genbank_protein_accession: BAJ34818.1 -> <empty>
      Changed sul1 WP_058685609.1
              genbank_protein_accession: ACO54027.1 -> <empty>
      Changed aac(3)-IId WP_063840265.1
              gene_family:    aac(3)-IIa -> aac(3)-IId
              product_name:   aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IId
      Changed aac(6')-Ib WP_063840281.1
              genbank_protein_accession: AAA26550.1 -> <empty>
      Changed aac(6')-Ib WP_063840282.1
              genbank_protein_accession: AAB88285.1 -> <empty>
      Changed aac(6')-Ib WP_063840283.1
              genbank_protein_accession: AAK51920.1 -> <empty>
      Changed aac(6')-Ib WP_063840319.1
              genbank_protein_accession: AAT70791.1 -> <empty>
      Changed aac(6')-Ib-cr6 WP_063840320.1
              genbank_protein_accession: ACD56150.1 -> <empty>
      Changed aadA6 WP_063840454.1
              genbank_protein_accession: CBM56270.1 -> <empty>
      Changed arr WP_063842207.1
              genbank_protein_accession: CAR63501.1 -> <empty>
      Changed cmlV WP_063844229.1
              genbank_protein_accession: AAB36568.1 -> <empty>
      Changed dfrB1 WP_063844476.1
              genbank_protein_accession: CAQ52800.1 -> <empty>
      Changed sul1 WP_063855103.1
              genbank_protein_accession: ACF06164.1 -> <empty>
      Changed tet(Q) WP_063856408.1
              genbank_protein_accession: AAB51122.1 -> <empty>
      Changed tet(Q) WP_063856409.1
              genbank_protein_accession: AAZ79478.1 -> <empty>
      Changed blaCARB-3 WP_063859105.1
              genbank_protein_accession: AAB19430.2 -> <empty>
      Changed blaCMY-59 WP_063859852.1
              genbank_protein_accession: BAJ17544.1 -> <empty>
      Changed qnrB14 WP_063865791.1
              genbank_protein_accession: ABX72044.1 -> <empty>
      Changed qnrB15 WP_063865798.1
              genbank_protein_accession: ABX72227.1 -> <empty>
      Changed qnrB16 WP_063865802.1
              genbank_protein_accession: ABV66096.1 -> <empty>
      Changed qnrB20 WP_063865914.1
              genbank_protein_accession: BAG55487.1 -> <empty>
      Changed qnrB23 WP_063865948.1
              genbank_protein_accession: ACS71747.1 -> <empty>
      Changed qnrB24 WP_063865960.1
              genbank_protein_accession: ADI46626.1 -> <empty>
      Changed qnrB26 WP_063865978.1
              genbank_protein_accession: AEH59666.1 -> <empty>
      Changed qnrB31 WP_063866022.1
              genbank_protein_accession: ADQ43424.1 -> <empty>
      Changed qnrB40 WP_063866081.1
              genbank_protein_accession: AEL31271.1 -> <empty>
      Changed qnrB41 WP_063866087.1
              genbank_protein_accession: AEL31272.1 -> <empty>
      Changed qnrB43 WP_063866099.1
              genbank_protein_accession: AFA52643.1 -> <empty>
      Changed qnrB44 WP_063866105.1
              genbank_protein_accession: AFA52645.1 -> <empty>
      Changed qnrB45 WP_063866109.1
              genbank_protein_accession: AFA52644.1 -> <empty>
      Changed qnrB46 WP_063866119.1
              genbank_protein_accession: AFA52646.1 -> <empty>
      Changed qnrB49 WP_063866135.1
              genbank_protein_accession: AFD54601.1 -> <empty>
      Changed qnrB5 WP_063866143.1
              curated_refseq_start: Yes -> No
      Changed qnrB53 WP_063866162.1
              genbank_protein_accession: ADW54092.1 -> <empty>
      Changed qnrB56 WP_063866184.1
              genbank_protein_accession: AFR46587.1 -> <empty>
      Changed qnrB57 WP_063866188.1
              genbank_protein_accession: AFR46588.1 -> <empty>
      Changed qnrB58 WP_063866193.1
              genbank_protein_accession: AFR46589.1 -> <empty>
      Changed qnrB59 WP_063866199.1
              genbank_protein_accession: AFR46590.1 -> <empty>
      Changed qnrB62 WP_063866224.1
              genbank_protein_accession: AFY16910.1 -> <empty>
      Changed kamB WP_063964000.1
              genbank_protein_accession: P25920.2 -> <empty>
      Changed kamB WP_063964001.1
              genbank_protein_accession: Q2MEY3.2 -> <empty>
      Changed sgm WP_063978071.1
              genbank_protein_accession: Q7M0R2.1 -> <empty>
      Changed tet(Z) WP_064190967.1
              genbank_protein_accession: AAD25063.1 -> <empty>
      Changed aac(6')-29a WP_064190968.1
              genbank_protein_accession: AAK26252.2 -> <empty>
      Changed aac(6')-29b WP_064190969.1
              genbank_protein_accession: AAK26254.2 -> <empty>
      Changed aac(6')-Ib WP_065187201.1
              genbank_protein_accession: KVJ45508.1 -> <empty>
      Changed aac(6')-Ip WP_069453146.1
              genbank_protein_accession: CAA91010.1 -> <empty>
      Changed blaFAR-1 WP_070064531.1
              genbank_protein_accession: AAB81957.1 -> <empty>
      Changed vanS WP_070064533.1
              genbank_protein_accession: AHA41504.1 -> <empty>
      Changed aac(6')-If WP_071593229.1
              genbank_protein_accession: CAA39038.1 -> <empty>
      Changed aac(6')-Ib-cr7 WP_071766399.1
              genbank_protein_accession: AMX43335.1 -> <empty>
      Changed blaMSI-1 WP_071766402.1
              genbank_protein_accession: AJP77057.1 -> <empty>
      Changed aac(6')-Ib-cr3 WP_071766621.1
              genbank_protein_accession: ADY02579.1 -> <empty>
      Changed arr-3 WP_071846202.1
              genbank_protein_accession: AHN09978.1 -> <empty>
      Changed aac(6')-Ib WP_071846208.1
              genbank_protein_accession: KDI62549.1 -> <empty>
      Changed aac(6')-Ib WP_071846209.1
              genbank_protein_accession: KDK90399.1 -> <empty>
      Changed aac(6')-Ib-cr WP_071846215.1
              genbank_protein_accession: ALM55696.1 -> <empty>
      Changed aac(6')-Ib WP_071846249.1
              genbank_protein_accession: CBI63204.2 -> <empty>
      Changed aac(6')-Ib WP_071846291.1
              genbank_protein_accession: CBL95256.1 -> <empty>
      Changed qacF WP_071846292.1
              genbank_protein_accession: CBM06475.1 -> <empty>
      Changed aadA6 WP_071846297.1
              genbank_protein_accession: CBM56264.1 -> <empty>
      Changed aadA6 WP_071846298.1
              genbank_protein_accession: CBM56266.1 -> <empty>
      Changed blaPSE WP_071846358.1
              genbank_protein_accession: ABM92282.1 -> <empty>
      Changed ant(2'')-Ia WP_071846368.1
              genbank_protein_accession: AEH59672.1 -> <empty>
      Changed blmA WP_072081991.1
              genbank_protein_accession: EME99227.1 -> <empty>
      Changed blaGOB-47 WP_073552023.1
              curated_refseq_start: Yes -> No
      Changed blaB-34 WP_078678782.1
              genbank_protein_accession: OPC54933.1 -> <empty>
      Changed blaB-27 WP_078772815.1
              genbank_protein_accession: OPC62103.1 -> <empty>
      Changed blaB-39 WP_078778510.1
              genbank_protein_accession: OPB88934.1 -> <empty>
      Changed aac(3)-Ib WP_079459897.1
              genbank_protein_accession: ADU90742.1 -> <empty>
      Changed blaB-36 WP_080889626.1
              genbank_protein_accession: AJW65208.1 -> <empty>
      Changed blaB-29 WP_081318900.1
              genbank_protein_accession: KUF46169.1 -> <empty>
      Changed blaOXA-671 WP_081401608.1
              genbank_protein_accession: EPF93312.1 -> <empty>
      Changed mcr-1.9 WP_099982800.1
              curated_refseq_start: Yes -> No
      Changed blaBUT-2 WP_104531864.1
              genbank_protein_accession: AAN17791.1 -> <empty>
      Changed blaB-28 WP_107808007.1
              genbank_protein_accession: PTW04273.1 -> <empty>
      Changed tet(S) WP_109544237.1
              genbank_protein_accession: AAT02170.1 -> <empty>
      Changed dfrA14 WP_109545031.1
              genbank_protein_accession: ABD46710.1 -> <empty>
      Changed qnrB11 WP_109545032.1
              genbank_protein_accession: ABS30107.1 -> <empty>
      Changed vanY-D WP_109545033.1
              genbank_protein_accession: ACM47285.1 -> <empty>
      Changed qnrB22 WP_109545034.1
              genbank_protein_accession: ACS71746.1 -> <empty>
      Changed qacF WP_109545035.1
              genbank_protein_accession: AHN60087.1 -> <empty>
      Changed tet(33) WP_109545038.1
              genbank_protein_accession: ABG49357.1 -> <empty>
      Changed blaSTA-1 WP_109545039.1
              genbank_protein_accession: EAU66413.1 -> <empty>
      Changed aph(3'')-Ib WP_109545041.1
              genbank_protein_accession: ACF57076.1 -> <empty>
      Changed blaORR-1 WP_109545042.1
              genbank_protein_accession: AFL96616.1 -> <empty>
      Changed blaECM-1 WP_122630824.1
              genbank_protein_accession: AFN85387.1 -> <empty>
      Changed aac(6')-Ib WP_140423191.1
              genbank_protein_accession: CCF72268.1 -> <empty>
      Changed aadA2 WP_140423281.1
              genbank_protein_accession: CCP09091.1 -> <empty>
      Changed blaKPC-53 WP_156649232.1
              curated_refseq_start: Yes -> No
      Changed blaCVI-1 WP_164461288.1
              genbank_protein_accession: QHN71476.1 -> <empty>
      Changed blaYRC-1 WP_168370989.1
              product_name: YRC family class C beta-lactamase YRC-1 -> class C beta-lactamase YRC-1
Families added
        Added family  NF038102.1      aac(6')-III
Families changed
      Updated family NF033088.1 bla-B1 to NF033088.2 bla-B1

----------------------------------------------------------------------
Changes included in 2020-05-04.1
----------------------------------------------------------------------

This update includes a change to the database format. It is compatible with
AMRFinderPlus versions in the 3.8 series. You will need to upgrade your
software to version 3.8 to use this database.

The reason for changing the database format is part of a larger NCBI directive
to move from using GIs to accessions as the primary identifier for sequences.
If that doesn't mean much to you it's ok. AMRFinderPlus should work in the same
way it did before.

Summary of other changes:
- Updated sequence for blaB-27 and blaB-34 to include two methionines at 5'
  start
- Fixed partial blaGOB-42
- We added GenBank accesions to many existing reference genes where previously there was a missing value
- Continued curation of new genes and alleles

- Reference Gene Catalog Changes
                   Added: 64
                 Removed: 0
                 Changed: 123
          Proteins added: 64
       NG_ records added: 62
          Total proteins: 6366
         Total mutations: 644
       Total NG_ records: 5498
                   Total: 7010
                    Added cdtB            AAT92048.1 cytolethal distending toxin type IV nuclease subunit CdtB
                    Added cdtB            BAF63361.1 cytolethal distending toxin type I nuclease subunit CdtB
                    Added blaOXA-914      NG_068185.1 WP_023132404.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-914
                    Added blaOXA-913      NG_068184.1 WP_031691948.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-913
                    Added mcr-1.26        NG_068217.1 WP_034169413.1 phosphoethanolamine--lipid A transferase MCR-1.26
                    Added blaOXA-912      NG_068183.1 WP_040068451.1 OXA-12 family class D beta-lactamase OXA-912
                    Added blaOXA-543      NG_068179.1 WP_058132644.1 OXA-2 family class D beta-lactamase OXA-543
                    Added blaCTX-M-140    NG_068166.1 WP_063108644.1 class A extended-spectrum beta-lactamase CTX-M-140
                    Added blaOXA-498      NG_068178.1 WP_063454569.1 OXA-211 family carbapenem-hydrolyzing class D beta-lactamase OXA-498
                    Added catA1           NG_047584.1 WP_063843217.1 type A-1 chloramphenicol O-acetyltransferase
                    Added blaSHV-171      NG_068212.1 WP_070984444.1 class A broad-spectrum beta-lactamase SHV-171
                    Added blaOXA-544      NG_068180.1 WP_071537493.1 OXA-2 family class D beta-lactamase OXA-544
                    Added blaACT-84       NG_068161.1 WP_072139974.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-84
                    Added blaGOB-47       NG_068223.1 WP_073552023.1 subclass B3 metallo-beta-lactamase GOB-47
                    Added blaGOB-28       NG_068171.1 WP_087093762.1 subclass B3 metallo-beta-lactamase GOB-28
                    Added blaB-30         NG_068164.1 WP_087094142.1 subclass B1 metallo-beta-lactamase BlaB-30
                    Added blaGOB-45       NG_068172.1 WP_102793805.1 subclass B3 metallo-beta-lactamase GOB-45
                    Added blaTEM-7        NG_068216.1 WP_109874025.1 class A extended-spectrum beta-lactamase TEM-7
                    Added blaTEM-5        NG_068215.1 WP_109963600.1 class A extended-spectrum beta-lactamase TEM-5
                    Added blaSHV-116      NG_068211.1 WP_117062210.1 class A beta-lactamase SHV-116
                    Added blaPDC-407      NG_068195.1 WP_124187209.1 class C beta-lactamase PDC-407
                    Added blaPDC-402      NG_068190.1 WP_134265631.1 class C beta-lactamase PDC-402
                    Added blaPDC-408      NG_068196.1 WP_134450540.1 class C beta-lactamase PDC-408
                    Added qnrVC9          NG_068219.1 WP_148560450.1 quinolone resistance pentapeptide repeat protein QnrVC9
                    Added blaACT-86       NG_068163.1 WP_152819218.1 ceftazidime-hydrolyzing class C beta-lactamase ACT-86
                    Added blaACT-85       NG_068162.1 WP_154123408.1 ceftazidime-hydrolyzing class C beta-lactamase ACT-85
                    Added blaKPC-53       NG_068176.1 WP_156649232.1 carbapenem-hydrolyzing class A beta-lactamase KPC-53
                    Added blaTEM-37       NG_068214.1 WP_159373457.1 inhibitor-resistant class A broad-spectrum beta-lactamase TEM-37
                    Added blaOXA-909      NG_068181.1 WP_162278338.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-909
                    Added mcr-1.27        NG_068218.1 WP_163397051.1 phosphoethanolamine--lipid A transferase MCR-1.27
                    Added blaTEM-31       NG_068213.1 WP_165539487.1 inhibitor-resistant class A broad-spectrum beta-lactamase TEM-31
                    Added blaCMY-171      NG_068165.1 WP_168247875.1 class C beta-lactamase CMY-171
                    Added blaCTX-M-153    NG_068167.1 WP_168247876.1 class A extended-spectrum beta-lactamase CTX-M-153
                    Added blaCTX-M-234    NG_068168.1 WP_168247877.1 class A extended-spectrum beta-lactamase CTX-M-234
                    Added blaCTX-M-235    NG_068169.1 WP_168247878.1 class A extended-spectrum beta-lactamase CTX-M-235
                    Added blaFOX-17       NG_068170.1 WP_168247879.1 cephalosporin-hydrolyzing class C beta-lactamase FOX-17
                    Added blaIDC-1        NG_068174.1 WP_168247881.1 class C beta-lactamase IDC-1
                    Added blaIDC-2        NG_068175.1 WP_168247882.1 class C beta-lactamase IDC-2
                    Added blaKPC-55       NG_068177.1 WP_168247883.1 carbapenem-hydrolyzing class A beta-lactamase KPC-55
                    Added blaOXA-911      NG_068182.1 WP_168247884.1 OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-911
                    Added blaPDC-398      NG_068186.1 WP_168247885.1 class C beta-lactamase PDC-398
                    Added blaPDC-399      NG_068187.1 WP_168247886.1 class C beta-lactamase PDC-399
                    Added blaPDC-400      NG_068188.1 WP_168247887.1 class C beta-lactamase PDC-400
                    Added blaPDC-401      NG_068189.1 WP_168247888.1 class C beta-lactamase PDC-401
                    Added blaPDC-403      NG_068191.1 WP_168247889.1 class C beta-lactamase PDC-403
                    Added blaPDC-404      NG_068192.1 WP_168247890.1 class C beta-lactamase PDC-404
                    Added blaPDC-405      NG_068193.1 WP_168247891.1 class C beta-lactamase PDC-405
                    Added blaPDC-406      NG_068194.1 WP_168247892.1 class C beta-lactamase PDC-406
                    Added blaPDC-409      NG_068197.1 WP_168247893.1 class C beta-lactamase PDC-409
                    Added blaPDC-410      NG_068198.1 WP_168247894.1 class C beta-lactamase PDC-410
                    Added blaPDC-411      NG_068199.1 WP_168247895.1 class C beta-lactamase PDC-411
                    Added blaPDC-412      NG_068200.1 WP_168247896.1 class C beta-lactamase PDC-412
                    Added blaPDC-413      NG_068201.1 WP_168247897.1 class C beta-lactamase PDC-413
                    Added blaPDC-414      NG_068202.1 WP_168247898.1 class C beta-lactamase PDC-414
                    Added blaPDC-415      NG_068203.1 WP_168247899.1 class C beta-lactamase PDC-415
                    Added blaPDC-416      NG_068204.1 WP_168247900.1 class C beta-lactamase PDC-416
                    Added blaPDC-417      NG_068205.1 WP_168247901.1 class C beta-lactamase PDC-417
                    Added blaPDC-418      NG_068206.1 WP_168247902.1 class C beta-lactamase PDC-418
                    Added blaPDC-419      NG_068207.1 WP_168247903.1 class C beta-lactamase PDC-419
                    Added blaPDC-420      NG_068208.1 WP_168247904.1 class C beta-lactamase PDC-420
                    Added blaPDC-421      NG_068209.1 WP_168247905.1 class C beta-lactamase PDC-421
                    Added blaPER-15       NG_068210.1 WP_168247906.1 class A extended-spectrum beta-lactamase PER-15
                    Added blaOXA-915      NG_068224.1 WP_168370988.1 OXA-134 family carbapenem-hydrolyzing class D beta-lactamase OXA-915
                    Added blaYRC-1        NG_068225.1 WP_168370989.1 YRC family class C beta-lactamase YRC-1
      Changes:
                  Changed blaB-27
                          refseq_protein_accession: WP_164461286.1 -> WP_078772815.1
                          refseq_nucleotide_accession: NG_067980.1 -> NG_067980.2
                          curated_refseq_start: No -> Yes
                          genbank_cds_stop: 343052 -> 343055
                  Changed blaB-34
                          refseq_protein_accession: WP_164461287.1 -> WP_078678782.1
                          refseq_nucleotide_accession: NG_067983.1 -> NG_067983.2
                          curated_refseq_start: No -> Yes
                          genbank_cds_stop: 202987 -> 202990
                  Changed blaGOB-42
                          refseq_protein_accession: WP_164461289.1 -> WP_047034183.1
                          refseq_nucleotide_accession: NG_068008.1 -> NG_068008.2
                          curated_refseq_start: No -> Yes
                          genbank_cds_stop: 2742885 -> 2742924
                  Changed iroE
                          genbank_protein_accession: YP_002527501.1 -> ACJ63530.1
                          genbank_nucleotide_accession:  -> CP001232.1
                          genbank_strand_orientation: - -> +
                          genbank_cds_start: <empty> -> 43893
                          genbank_cds_stop: <empty> -> 44849
                  Changed aac(3)-VIa WP_000131886.1
                          genbank_protein_accession: <empty> -> ABF67772.1
                  Changed tet(A) WP_000804063.1
                          genbank_protein_accession: <empty> -> AAN06707.1
                  Changed aacA57-2 WP_000959805.1
                          genbank_protein_accession: <empty> -> CAM88403.1
                  Changed qnrB6 WP_001749994.1
                          genbank_protein_accession: <empty> -> ABP87778.1
                  Changed aac(3)-Ia WP_022542381.1
                          genbank_protein_accession: <empty> -> AAB20441.1
                  Changed blaCARB-23 WP_025442943.1
                          genbank_protein_accession: <empty> -> AHJ02283.1
                  Changed blaCARB-21 WP_025632811.1
                          genbank_protein_accession: <empty> -> AGQ93789.1
                  Changed blaALI-1 WP_026025287.1
                          genbank_protein_accession: <empty> -> CAQ78899.1
                  Changed dfrA25 WP_029391998.1
                          genbank_protein_accession: <empty> -> ABB71176.1
                  Changed tet(31) WP_031204920.1
                          genbank_protein_accession: <empty> -> CAC80727.1
                  Changed blaGOB-39 WP_031257659.1
                          genbank_protein_accession: <empty> -> EQB91719.1
                  Changed qnrB18 WP_032941855.1
                          genbank_protein_accession: <empty> -> CAP45903.1
                  Changed qnrB30 WP_032944434.1
                          genbank_protein_accession: <empty> -> ADM52194.1
                  Changed qnrB12 WP_038640920.1
                          genbank_protein_accession: <empty> -> CAO82104.1
                  Changed erm(44)v WP_041079981.1
                          genbank_protein_accession: <empty> -> CUU67654.1
                  Changed blaSGM-2 WP_041385949.1
                          genbank_protein_accession: <empty> -> BAI97006.1
                  Changed aacA47 WP_041550454.1
                          genbank_protein_accession: <empty> -> AFY97005.1
                  Changed catA13 WP_043774378.1
                          genbank_protein_accession: <empty> -> ABO92401.1
                  Changed erm(42) WP_052259183.1
                          genbank_protein_accession: <empty> -> BAJ34818.1
                  Changed sul1 WP_058685609.1
                          genbank_protein_accession: <empty> -> ACO54027.1
                  Changed aac(6')-Ib WP_063840281.1
                          genbank_protein_accession: <empty> -> AAA26550.1
                  Changed aac(6')-Ib WP_063840282.1
                          genbank_protein_accession: <empty> -> AAB88285.1
                  Changed aac(6')-Ib WP_063840283.1
                          genbank_protein_accession: <empty> -> AAK51920.1
                  Changed aac(6')-Ib WP_063840319.1
                          genbank_protein_accession: <empty> -> AAT70791.1
                  Changed aac(6')-Ib-cr6 WP_063840320.1
                          genbank_protein_accession: <empty> -> ACD56150.1
                  Changed aadA6 WP_063840454.1
                          genbank_protein_accession: <empty> -> CBM56270.1
                  Changed arr WP_063842207.1
                          genbank_protein_accession: <empty> -> CAR63501.1
                  Changed cmlV WP_063844229.1
                          genbank_protein_accession: <empty> -> AAB36568.1
                  Changed dfrB1 WP_063844476.1
                          genbank_protein_accession: <empty> -> CAQ52800.1
                  Changed sul1 WP_063855103.1
                          genbank_protein_accession: <empty> -> ACF06164.1
                  Changed tet(Q) WP_063856408.1
                          genbank_protein_accession: <empty> -> AAB51122.1
                  Changed tet(Q) WP_063856409.1
                          genbank_protein_accession: <empty> -> AAZ79478.1
                  Changed blaCARB-3 WP_063859105.1
                          genbank_protein_accession: <empty> -> AAB19430.2
                  Changed blaCMY-59 WP_063859852.1
                          genbank_protein_accession: <empty> -> BAJ17544.1
                  Changed qnrB14 WP_063865791.1
                          genbank_protein_accession: <empty> -> ABX72044.1
                  Changed qnrB15 WP_063865798.1
                          genbank_protein_accession: <empty> -> ABX72227.1
                  Changed qnrB16 WP_063865802.1
                          genbank_protein_accession: <empty> -> ABV66096.1
                  Changed qnrB20 WP_063865914.1
                          genbank_protein_accession: <empty> -> BAG55487.1
                  Changed qnrB23 WP_063865948.1
                          genbank_protein_accession: <empty> -> ACS71747.1
                  Changed qnrB24 WP_063865960.1
                          genbank_protein_accession: <empty> -> ADI46626.1
                  Changed qnrB26 WP_063865978.1
                          genbank_protein_accession: <empty> -> AEH59666.1
                  Changed qnrB31 WP_063866022.1
                          genbank_protein_accession: <empty> -> ADQ43424.1
                  Changed qnrB40 WP_063866081.1
                          genbank_protein_accession: <empty> -> AEL31271.1
                  Changed qnrB41 WP_063866087.1
                          genbank_protein_accession: <empty> -> AEL31272.1
                  Changed qnrB43 WP_063866099.1
                          genbank_protein_accession: <empty> -> AFA52643.1
                  Changed qnrB44 WP_063866105.1
                          genbank_protein_accession: <empty> -> AFA52645.1
                  Changed qnrB45 WP_063866109.1
                          genbank_protein_accession: <empty> -> AFA52644.1
                  Changed qnrB46 WP_063866119.1
                          genbank_protein_accession: <empty> -> AFA52646.1
                  Changed qnrB49 WP_063866135.1
                          genbank_protein_accession: <empty> -> AFD54601.1
                  Changed qnrB53 WP_063866162.1
                          genbank_protein_accession: <empty> -> ADW54092.1
                  Changed qnrB56 WP_063866184.1
                          genbank_protein_accession: <empty> -> AFR46587.1
                  Changed qnrB57 WP_063866188.1
                          genbank_protein_accession: <empty> -> AFR46588.1
                  Changed qnrB58 WP_063866193.1
                          genbank_protein_accession: <empty> -> AFR46589.1
                  Changed qnrB59 WP_063866199.1
                          genbank_protein_accession: <empty> -> AFR46590.1
                  Changed qnrB62 WP_063866224.1
                          genbank_protein_accession: <empty> -> AFY16910.1
                  Changed kamB WP_063964000.1
                          genbank_protein_accession: <empty> -> P25920.2
                  Changed kamB WP_063964001.1
                          genbank_protein_accession: <empty> -> Q2MEY3.2
                  Changed sgm WP_063978071.1
                          genbank_protein_accession: <empty> -> Q7M0R2.1
                  Changed tet(Z) WP_064190967.1
                          genbank_protein_accession: <empty> -> AAD25063.1
                  Changed aac(6')-29a WP_064190968.1
                          genbank_protein_accession: <empty> -> AAK26252.2
                  Changed aac(6')-29b WP_064190969.1
                          genbank_protein_accession: <empty> -> AAK26254.2
                  Changed aac(6')-Ib WP_065187201.1
                          genbank_protein_accession: <empty> -> KVJ45508.1
                  Changed aac(6')-Ip WP_069453146.1
                          genbank_protein_accession: <empty> -> CAA91010.1
                  Changed blaFAR-1 WP_070064531.1
                          genbank_protein_accession: <empty> -> AAB81957.1
                  Changed vanS WP_070064533.1
                          genbank_protein_accession: <empty> -> AHA41504.1
                  Changed aac(6')-If WP_071593229.1
                          genbank_protein_accession: <empty> -> CAA39038.1
                  Changed aac(6')-Ib-cr7 WP_071766399.1
                          genbank_protein_accession: <empty> -> AMX43335.1
                  Changed blaMSI-1 WP_071766402.1
                          genbank_protein_accession: <empty> -> AJP77057.1
                  Changed aac(6')-Ib-cr3 WP_071766621.1
                          genbank_protein_accession: <empty> -> ADY02579.1
                  Changed arr-3 WP_071846202.1
                          genbank_protein_accession: <empty> -> AHN09978.1
                  Changed aac(6')-Ib WP_071846208.1
                          genbank_protein_accession: <empty> -> KDI62549.1
                  Changed aac(6')-Ib WP_071846209.1
                          genbank_protein_accession: <empty> -> KDK90399.1
                  Changed aac(6')-Ib-cr WP_071846215.1
                          genbank_protein_accession: <empty> -> ALM55696.1
                  Changed aac(6')-Ib WP_071846249.1
                          genbank_protein_accession: <empty> -> CBI63204.2
                  Changed aac(6')-Ib WP_071846291.1
                          genbank_protein_accession: <empty> -> CBL95256.1
                  Changed qacF WP_071846292.1
                          genbank_protein_accession: <empty> -> CBM06475.1
                  Changed aadA6 WP_071846297.1
                          genbank_protein_accession: <empty> -> CBM56264.1
                  Changed aadA6 WP_071846298.1
                          genbank_protein_accession: <empty> -> CBM56266.1
                  Changed blaPSE WP_071846358.1
                          genbank_protein_accession: <empty> -> ABM92282.1
                  Changed ant(2'')-Ia WP_071846368.1
                          genbank_protein_accession: <empty> -> AEH59672.1
                  Changed blmA WP_072081991.1
                          genbank_protein_accession: <empty> -> EME99227.1
                  Changed blaB-39 WP_078778510.1
                          genbank_protein_accession: <empty> -> OPB88934.1
                  Changed aac(3)-Ib WP_079459897.1
                          genbank_protein_accession: <empty> -> ADU90742.1
                  Changed blaB-36 WP_080889626.1
                          genbank_protein_accession: <empty> -> AJW65208.1
                  Changed blaB-29 WP_081318900.1
                          genbank_protein_accession: <empty> -> KUF46169.1
                  Changed blaOXA-671 WP_081401608.1
                          genbank_protein_accession: <empty> -> EPF93312.1
                  Changed icr-Mo WP_082741435.1
                          genbank_protein_accession: WP_082741435.1 -> <empty>
                          refseq_protein_accession: <empty> -> WP_082741435.1
                  Changed blaBUT-2 WP_104531864.1
                          genbank_protein_accession: <empty> -> AAN17791.1
                  Changed blaB-28 WP_107808007.1
                          genbank_protein_accession: <empty> -> PTW04273.1
                  Changed tet(S) WP_109544237.1
                          genbank_protein_accession: <empty> -> AAT02170.1
                  Changed dfrA14 WP_109545031.1
                          genbank_protein_accession: <empty> -> ABD46710.1
                  Changed qnrB11 WP_109545032.1
                          genbank_protein_accession: <empty> -> ABS30107.1
                  Changed vanY-D WP_109545033.1
                          genbank_protein_accession: <empty> -> ACM47285.1
                  Changed qnrB22 WP_109545034.1
                          genbank_protein_accession: <empty> -> ACS71746.1
                  Changed qacF WP_109545035.1
                          genbank_protein_accession: <empty> -> AHN60087.1
                  Changed tet(33) WP_109545038.1
                          genbank_protein_accession: <empty> -> ABG49357.1
                  Changed blaSTA-1 WP_109545039.1
                          genbank_protein_accession: <empty> -> EAU66413.1
                  Changed aph(3'')-Ib WP_109545041.1
                          genbank_protein_accession: <empty> -> ACF57076.1
                  Changed blaORR-1 WP_109545042.1
                          genbank_protein_accession: <empty> -> AFL96616.1
                  Changed blaECM-1 WP_122630824.1
                          genbank_protein_accession: <empty> -> AFN85387.1
                  Changed aac(6')-Ib WP_140423191.1
                          genbank_protein_accession: <empty> -> CCF72268.1
                  Changed aadA2 WP_140423281.1
                          genbank_protein_accession: <empty> -> CCP09091.1
                  Changed blaACT-73 WP_152315464.1
                          genbank_nucleotide_accession: KJ949129.1 -> KJ949129.2
                          refseq_nucleotide_accession: NG_066689.1 -> NG_066689.2
                  Changed blaCVI-1 WP_164461288.1
                          genbank_protein_accession: <empty> -> QHN71476.1
                  Changed parE_D475E WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_D476N WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_E460D WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_E460K WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_G423R WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I355T WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I444F WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I464F WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I470M WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_I529L WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_L416F WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_L445H WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_P439S WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_S458A WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
                  Changed parE_S458T WP_033554192.1
                          genbank_protein_accession: EAA4575386.1 -> RRN00056.1
- AMR HMM library Changes:
                  Total:  Added           1
                  Total:  Prev. Release   625
                  Total:  Removed         0
                  Total:  This Release    626
              HMM Added:  NF038089.1      blaYRC-NCBI
- Protein family changes:
                  Total:  Added           3
                  Total:  Prev. Release   1567
                  Total:  Removed         0
                  Total:  This Release    1570
           Family Added:  NF038089.1      blaYRC
           Family Added:  -               cdtB_I
           Family Added:  -               cdtB_IV
----------------------------------------------------------------------
Changes included in 2020-03-20.1
----------------------------------------------------------------------
Summary of changes:
- Added curated Staphylococcus aureus SNPs
- Reorganization and extensive curation of aac(6')-Ib with updates for
  specific drug resistance information where site-specific dependencies are known
- Removal of a few protein sequences that were found to be incomplete
- Blacklisting --organism option for Staphylococcus pseudintermedius changed to
  --organism=Staphylococcus_pseudintermedius
- Added --organism=Staphylococcus_aureus for Staph. aureus SNPs
- Several new HMMs added

- Reference Gene Catalog Changes
                   Added: 278
                 Removed: 4
                 Changed: 60
          Total proteins: 6302
         Total mutations: 644
                   Total: 6946

                  Removed mchF            AAX22079.2 microcin H47 export transporter peptidase/ATP-binding subunit MchF
                  Removed mchF            AFQ65076.1 microcin H47 export transporter peptidase/ATP-binding subunit MchF
                  Removed chrR            BAA11821.1 class I chromate reductase ChrR
                  Removed aac(3)-IVa      WP_063840268.1 aminoglycoside N-acetyltransferase AAC(3)-IVa
                    Added 23S_C2579T      LINEZOLID Staphylococcus_aureus
                    Added 23S_G2577T      LINEZOLID Staphylococcus_aureus
                    Added 23S_G2604T      LINEZOLID Staphylococcus_aureus
                    Added 23S_T2501A      LINEZOLID Staphylococcus_aureus
                    Added almG            AAF94731.1 glycine--lipid A transferase AlmG
                    Added abaF            ABO11759.2 fosfomycin efflux MFS transporter AbaF
                    Added papF            CAA43569.1 P fimbrial tip protein PapF
                    Added blaOXA-904      WP_003122322.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-904
                    Added blaOXA-905      WP_003161096.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-905
                    Added blaGOB-20       WP_009089555.1 subclass B3 metallo-beta-lactamase GOB-20
                    Added blaGOB-22       WP_019050927.1 subclass B3 metallo-beta-lactamase GOB-22
                    Added blaGOB-21       WP_024566153.1 subclass B3 metallo-beta-lactamase GOB-21
                    Added blaGOB-26       WP_024567831.1 subclass B3 metallo-beta-lactamase GOB-26
                    Added blaOXA-902      WP_024916334.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-902
                    Added blaGOB-39       WP_031257659.1 subclass B3 metallo-beta-lactamase GOB-39
                    Added blaOXA-908      WP_031694184.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-908
                    Added blaOXA-901      WP_031757092.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-901
                    Added blaOXA-906      WP_034005326.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-906
                    Added blaGOB-40       WP_034845394.1 subclass B3 metallo-beta-lactamase GOB-40
                    Added qnrA10          WP_044735234.1 quinolone resistance pentapeptide repeat protein QnrA10
                    Added blaGOB-49       WP_045183849.1 subclass B3 metallo-beta-lactamase GOB-49
                    Added blaGOB-38       WP_058879139.1 subclass B3 metallo-beta-lactamase GOB-38
                    Added blaGOB-37       WP_059323095.1 subclass B3 metallo-beta-lactamase GOB-37
                    Added blaGOB-25       WP_059345125.1 subclass B3 metallo-beta-lactamase GOB-25
                    Added aac(6')-Ib      WP_064765190.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-32       WP_065081961.1 subclass B3 metallo-beta-lactamase GOB-32
                    Added aac(6')-Ib      WP_069067473.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-27       WP_069213816.1 subclass B3 metallo-beta-lactamase GOB-27
                    Added aac(6')-Ib      WP_071984682.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_072201103.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-41       WP_078395323.1 subclass B3 metallo-beta-lactamase GOB-41
                    Added blaGOB-51       WP_078402651.1 subclass B3 metallo-beta-lactamase GOB-51
                    Added blaGOB-43       WP_078407131.1 subclass B3 metallo-beta-lactamase GOB-43
                    Added blaGOB-50       WP_078675023.1 subclass B3 metallo-beta-lactamase GOB-50
                    Added blaGOB-30       WP_078676551.1 subclass B3 metallo-beta-lactamase GOB-30
                    Added blaGOB-29       WP_078678126.1 subclass B3 metallo-beta-lactamase GOB-29
                    Added blaGOB-31       WP_078703439.1 subclass B3 metallo-beta-lactamase GOB-31
                    Added blaGOB-36       WP_078722646.1 subclass B3 metallo-beta-lactamase GOB-36
                    Added blaGOB-48       WP_078724262.1 subclass B3 metallo-beta-lactamase GOB-48
                    Added blaGOB-46       WP_078769980.1 subclass B3 metallo-beta-lactamase GOB-46
                    Added blaB-39         WP_078778510.1 subclass B1 metallo-beta-lactamase BlaB-39
                    Added blaGOB-35       WP_078779188.1 subclass B3 metallo-beta-lactamase GOB-35
                    Added blaGOB-44       WP_078793281.1 subclass B3 metallo-beta-lactamase GOB-44
                    Added blaGOB-23       WP_078795634.1 subclass B3 metallo-beta-lactamase GOB-23
                    Added blaGOB-33       WP_078797000.1 subclass B3 metallo-beta-lactamase GOB-33
                    Added aac(6')-Ib      WP_079452738.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(3)-Ib       WP_079459897.1 aminoglycoside N-acetyltransferase AAC(3)-Ib
                    Added blaB-36         WP_080889626.1 subclass B1 metallo-beta-lactamase BlaB-36
                    Added blaB-29         WP_081318900.1 subclass B1 metallo-beta-lactamase BlaB-29
                    Added aac(6')-Ib      WP_085843736.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_085844237.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaKPC-56       WP_087744800.1 carbapenem-hydrolyzing class A beta-lactamase KPC-56
                    Added aac(6')-Ib      WP_087872512.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaGOB-24       WP_101360689.1 subclass B3 metallo-beta-lactamase GOB-24
                    Added aac(6')-Ib      WP_101516660.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_104442471.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaB-28         WP_107808007.1 subclass B1 metallo-beta-lactamase BlaB-28
                    Added blaGOB-34       WP_107809858.1 subclass B3 metallo-beta-lactamase GOB-34
                    Added aac(6')-Ib      WP_113613509.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_117044474.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_117046752.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_117065919.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added tet(W)          WP_122634437.1 tetracycline resistance ribosomal protection protein Tet(W)
                    Added aac(6')-Ib      WP_123085936.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib-cr10 WP_124042715.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr10
                    Added aac(6')-Ib      WP_126123880.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaRSA2-1       WP_128268281.1 carbapenem-hydrolyzing class A beta-lactamase RSA2-1
                    Added blaRSC1-1       WP_128268282.1 RSC1 family class C beta-lactamase
                    Added blaRSD1-1       WP_128268283.1 RSD1 family class D beta-lactamase
                    Added blaRSD2-1       WP_128268284.1 class D beta-lactamase RSD2-1
                    Added blaRSD2-2       WP_128268285.1 class D beta-lactamase RSD2-2
                    Added aac(6')-Ib-cr9  WP_131534982.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr9
                    Added blaADC-235      WP_132038428.1 class C beta-lactamase ADC-235
                    Added aac(6')-Ib      WP_132629969.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib      WP_134628915.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added tet(55)         WP_148044404.1 tetracycline destructase Tet(55)
                    Added blaIMP-81       WP_148044415.1 subclass B1 metallo-beta-lactamase IMP-81
                    Added blaPNGM-1       WP_148044471.1 subclass B3-like metallo-beta-lactamase PNGM-1
                    Added aac(6')-Ib      WP_148937512.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added aac(6')-Ib-cr8  WP_151346866.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr8
                    Added aac(6')-Ib      WP_151405943.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaOXA-899      WP_154205474.1 OXA-22 family class D beta-lactamase OXA-899
                    Added blaOXA-898      WP_154205589.1 OXA-60 family carbapenem-hydrolyzing class D beta-lactamase OXA-898
                    Added blaADC-234      WP_159162532.1 class C beta-lactamase ADC-234
                    Added aac(6')-Ib-cr11 WP_159241551.1 fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr11
                    Added aac(6')-Ib      WP_159287722.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
                    Added blaOXA-910      WP_162280230.1 OXA-51 family carbapenem-hydrolyzing class D beta-lactamase OXA-910
                    Added blaACT-78       WP_164461280.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-78
                    Added blaACT-79       WP_164461281.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-79
                    Added blaACT-80       WP_164461282.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-80
                    Added blaACT-81       WP_164461283.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-81
                    Added blaACT-82       WP_164461284.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-82
                    Added blaACT-83       WP_164461285.1 cephalosporin-hydrolyzing class C beta-lactamase ACT-83
                    Added blaB-27         WP_164461286.1 subclass B1 metallo-beta-lactamase BlaB-27
                    Added blaB-34         WP_164461287.1 subclass B1 metallo-beta-lactamase BlaB-34
                    Added blaCVI-1        WP_164461288.1 subclass B2 metallo-beta-lactamase CVI-1
                    Added blaGOB-42       WP_164461289.1 subclass B3 metallo-beta-lactamase GOB-42
                    Added blaOXA-897      WP_164461290.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-897
                    Added blaOXA-903      WP_164461291.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-903
                    Added blaOXA-907      WP_164461292.1 OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-907
                    Added blaPDC-389      WP_164461293.1 class C beta-lactamase PDC-389
                    Added blaPDC-390      WP_164461294.1 class C beta-lactamase PDC-390
                    Added blaPDC-391      WP_164461295.1 class C beta-lactamase PDC-391
                    Added blaPDC-392      WP_164461296.1 class C beta-lactamase PDC-392
                    Added blaPDC-393      WP_164461297.1 class C beta-lactamase PDC-393
                    Added blaPDC-394      WP_164461298.1 class C beta-lactamase PDC-394
                    Added blaPDC-395      WP_164461299.1 class C beta-lactamase PDC-395
                    Added blaPDC-396      WP_164461300.1 class C beta-lactamase PDC-396
                    Added blaPDC-397      WP_164461301.1 class C beta-lactamase PDC-397
                    Added blaVIM-70       WP_164461303.1 subclass B1 metallo-beta-lactamase VIM-70
                    Added blaCMY-136      WP_164924988.1 class C beta-lactamase CMY-136
                    Added cls_A23V        DAPTOMYCIN Staphylococcus_aureus
                    Added cls_F60S        DAPTOMYCIN Staphylococcus_aureus
                    Added cls_L52F        DAPTOMYCIN Staphylococcus_aureus
                    Added cls_T33N        DAPTOMYCIN Staphylococcus_aureus
                    Added dfrB_F99I       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_F99S       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_F99Y       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_H150R      TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_H31N       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_L21V       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_L41F       TRIMETHOPRIM Staphylococcus_aureus
                    Added dfrB_N60I       TRIMETHOPRIM Staphylococcus_aureus
                    Added fusA_A160V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_A655E      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_A655P      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_A655V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_C473S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D189G      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D189V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D434N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_D463G      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_E233Q      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_E444K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_E444V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_F652S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_F88L       FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G451V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G452C      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G452S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G452V      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G556S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G617D      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_G664S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_H438N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_H457Q      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_H457Y      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L430S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L456F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L456K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L461F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L461K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_L461S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_M453I      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_M651I      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P114H      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P404L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P404Q      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P406L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_P478S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_Q115L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464C      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464H      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R464S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659C      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659H      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659L      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_R659S      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_S416F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_T385N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_T436I      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_T656K      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_V407F      FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_V90A       FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_V90I       FUSIDIC ACID Staphylococcus_aureus
                    Added fusA_Y654N      FUSIDIC ACID Staphylococcus_aureus
                    Added fusE_Q140L      FUSIDIC ACID Staphylococcus_aureus
                    Added glpT_F3I        FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_G352D      FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_L27F       FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_V213I      FOSFOMYCIN Staphylococcus_aureus
                    Added glpT_W137R      FOSFOMYCIN Staphylococcus_aureus
                    Added gyrA_E88G       QUINOLONE Staphylococcus_aureus
                    Added gyrA_E88K       QUINOLONE Staphylococcus_aureus
                    Added gyrA_E88L       QUINOLONE Staphylococcus_aureus
                    Added gyrA_G106D      QUINOLONE Staphylococcus_aureus
                    Added gyrA_S84A       QUINOLONE Staphylococcus_aureus
                    Added gyrA_S84L       QUINOLONE Staphylococcus_aureus
                    Added gyrA_S85P       QUINOLONE Staphylococcus_aureus
                    Added gyrB_G84S       AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_I101S      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_I55S       AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_R143I      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_R143S      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_S127L      AMINOCOUMARIN Staphylococcus_aureus
                    Added gyrB_T172A      AMINOCOUMARIN Staphylococcus_aureus
                    Added ileS_V588F      MUPIROCIN Staphylococcus_aureus
                    Added ileS_V631F      MUPIROCIN Staphylococcus_aureus
                    Added mprF_G61V       DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_I420N      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_L341S      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_L826F      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_M347R      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_P314L      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_S295L      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_S337L      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T345A      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T345I      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T345K      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_T472K      DAPTOMYCIN Staphylococcus_aureus
                    Added mprF_V351E      DAPTOMYCIN Staphylococcus_aureus
                    Added murA_D278E      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_E291D      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_G257D      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_Q362R      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_T396N      FOSFOMYCIN Staphylococcus_aureus
                    Added murA_V65A       FOSFOMYCIN Staphylococcus_aureus
                    Added parC_A116E      QUINOLONE Staphylococcus_aureus
                    Added parC_E84G       QUINOLONE Staphylococcus_aureus
                    Added parC_E84K       QUINOLONE Staphylococcus_aureus
                    Added parC_E84L       QUINOLONE Staphylococcus_aureus
                    Added parC_E84V       QUINOLONE Staphylococcus_aureus
                    Added parC_S80F       QUINOLONE Staphylococcus_aureus
                    Added parC_S80Y       QUINOLONE Staphylococcus_aureus
                    Added parC_Y83N       QUINOLONE Staphylococcus_aureus
                    Added parE_D432H      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_D432N      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_G78S       QUINOLONE Staphylococcus_aureus
                    Added parE_N470S      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_P585S      AMINOCOUMARIN Staphylococcus_aureus
                    Added parE_R136G      QUINOLONE Staphylococcus_aureus
                    Added pbp2_S569A      CEPHALOSPORIN Staphylococcus_aureus
                    Added pbp4_E183A      CEPHALOSPORIN Staphylococcus_aureus
                    Added pbp4_F241R      CEPHALOSPORIN Staphylococcus_aureus
                    Added pgsA_A64V       DAPTOMYCIN Staphylococcus_aureus
                    Added pgsA_K66R       DAPTOMYCIN Staphylococcus_aureus
                    Added pgsA_S177F      DAPTOMYCIN Staphylococcus_aureus
                    Added pgsA_V59N       DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_A1085V     DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_A473T      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A477D      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A477T      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A477V      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_A621E      DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_D471G      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_D471Y      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_D550G      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_H481D      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_H481N      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_H481Y      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I527F      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I527L      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I527M      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_I953S      DAPTOMYCIN Staphylococcus_aureus
                    Added rpoB_L466S      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_M470T      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_N474KG     RIFAMPIN Staphylococcus_aureus
                    Added rpoB_N474K      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_N474NH     RIFAMPIN Staphylococcus_aureus
                    Added rpoB_Q465K      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_Q465R      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_Q468K      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_R484H      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S463P      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S464P      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S486L      RIFAMPIN Staphylococcus_aureus
                    Added rpoB_S529L      RIFAMPIN Staphylococcus_aureus
                    Added rpoC_F632S      DAPTOMYCIN Staphylococcus_aureus
                    Added rpoC_Q961K      DAPTOMYCIN Staphylococcus_aureus
                    Added uhpT_G112E      FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_G358V      FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_W228STOP   FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_W425R      FOSFOMYCIN Staphylococcus_aureus
                    Added uhpT_Y314STOP   FOSFOMYCIN Staphylococcus_aureus
                    Added walK_L10F       DAPTOMYCIN Staphylococcus_aureus
                    Added walK_R263C      DAPTOMYCIN Staphylococcus_aureus
                    Added walK_S221P      DAPTOMYCIN Staphylococcus_aureus
  Changes:
     Changed faeG AAA24032.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG AAA24035.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG AAA24390.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed arsB AAA25637.1
        blacklisted_taxa: Staphylococcus -> Staphylococcus_pseudintermedius
     Changed arsB AAA27588.1
        blacklisted_taxa: Staphylococcus -> Staphylococcus_pseudintermedius
     Changed faeG AAC34727.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG ACB72721.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG AFH14350.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG CAE82650.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG CAE82653.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed faeG CAE82670.1
            product_name: F4 (K88) fimbrial adhesin subunit FaeG -> F4 (K88) fimbria major subunit/adhesin FaeG
     Changed iucA EGI25746.1
       genbank_cds_start:  -> 406312
        genbank_cds_stop:  -> 408042
genbank_nucleotide_accession:  -> GL884188.1
     Changed aac(3)-IIe WP_000557452.1
             gene_family: aac(3)-IIa -> aac(3)-IIe
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe
     Changed aac(3)-IId WP_000557454.1
                  allele: aac(3)-IId ->
             gene_family: aac(3)-II -> aac(3)-IId
     Changed aac(3)-IVa WP_001199192.1
             gene_family: aac(3)-IV -> aac(3)-IVa
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IV -> aminoglycoside N-acetyltransferase AAC(3)-IVa
     Changed aac(3)-IIe WP_002063884.1
             gene_family: aac(3)-IIa -> aac(3)-IIe
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe
     Changed aac(3)-Ia WP_002089484.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Id WP_003155734.1
             gene_family: aac(3)-I -> aac(3)-Id
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Id
     Changed aac(3)-Ib WP_010792467.1
                  allele: aac(3)-Ib ->
             gene_family: aac(3)-I -> aac(3)-Ib
     Changed aac(3)-Ig WP_011468318.1
                  allele: aac(3)-Ig ->
             gene_family: aac(3)-I -> aac(3)-Ig
     Changed aac(3)-Ii WP_011540937.1
                  allele: aac(3)-Ii ->
             gene_family: aac(3)-I -> aac(3)-Ii
     Changed aac(3)-Ih WP_011749610.1
                  allele: aac(3)-Ih ->
             gene_family: aac(3)-I -> aac(3)-Ih
     Changed aac(6')-Ib WP_013250882.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(6')-Ib' WP_014454105.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(3)-IIe WP_015060297.1
             gene_family: aac(3)-IIa -> aac(3)-IIe
            product_name: aminoglycoside N-acetyltransferase AAC(3)-IIa -> aminoglycoside N-acetyltransferase AAC(3)-IIe
     Changed mphM WP_016078774.1
             gene_family: mph(B) -> mphM
            product_name: Mph(B) family macrolide 2'-phosphotransferase -> macrolide 2'-phosphotransferase MphM
     Changed aac(3)-Ia WP_022542381.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(6')-Ib WP_022631510.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(6')-Ib11 WP_032490438.1
                subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(3)-Ia WP_032491356.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Ia WP_032492247.1
                  allele: aac(3)-Ia ->
    curated_refseq_start: No -> Yes
             gene_family: aac(3)-I -> aac(3)-Ia
     Changed aac(3)-IIb WP_033147097.1
                  allele: aac(3)-IIb ->
             gene_family: aac(3)-II -> aac(3)-IIb
     Changed aac(3)-Ic WP_034006142.1
                  allele: aac(3)-Ic ->
             gene_family: aac(3)-I -> aac(3)-Ic
     Changed aac(3)-Id WP_038404949.1
                  allele: aac(3)-Id ->
             gene_family: aac(3)-I -> aac(3)-Id
     Changed blaMCA WP_057991970.1
             gene_family: ampC -> blaMCA
     Changed  WP_063838853.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed  WP_063839875.1
                subclass: AMINOGLYCOSIDE -> STREPTOMYCIN/SPECTINOMYCIN
     Changed aac(3)-Ia WP_063840257.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Ia WP_063840258.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-Ia WP_063840259.1
             gene_family: aac(3)-I -> aac(3)-Ia
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-Ia
     Changed aac(3)-IIc WP_063840266.1
                  allele: aac(3)-IIc ->
             gene_family: aac(3)-II -> aac(3)-IIc
     Changed aac(6')-Ib WP_063840281.1
                subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib WP_063840282.1
                subclass: AMINOGLYCOSIDE -> KANAMYCIN
     Changed aac(6')-Ib WP_063840283.1
                subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib WP_063840319.1
                subclass: AMINOGLYCOSIDE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib-cr6 WP_063840320.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib-cr5 WP_063840321.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(3)-If WP_063856942.1
                  allele: aac(3)-If ->
             gene_family: aac(3)-I -> aac(3)-If
     Changed blaADC-68 WP_063857815.1
                subclass: CEPHALOSPORIN -> CARBAPENEM
     Changed aac(6')-Ib-cr4 WP_065187000.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib WP_065187201.1
                subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib11 WP_069985732.1
                subclass: AMIKACIN/KANAMYCIN/TOBRAMYCIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed  WP_071593228.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN
     Changed aac(6')-Ib-cr7 WP_071766399.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib-cr3 WP_071766621.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib-cr WP_071846215.1
                subclass: AMIKACIN/QUINOLONE -> AMIKACIN/KANAMYCIN/TOBRAMYCIN/QUINOLONE
     Changed aac(6')-Ib WP_071846254.1
                subclass: GENTAMICIN -> AMIKACIN/GENTAMICIN/KANAMYCIN/TOBRAMYCIN
     Changed aac(6')-Ib WP_071846329.1
             gene_family: aac(6')-Ib' -> aac(6')-Ib
            product_name: aminoglycoside N-acetyltransferase AAC(6')-Ib' -> AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase
     Changed aac(3)-If WP_071846359.1
             gene_family: aac(3)-I -> aac(3)-If
            product_name: AAC(3)-I family aminoglycoside 3-N-acetyltransferase -> aminoglycoside N-acetyltransferase AAC(3)-If
     Changed aac(6')-Ib WP_071846382.1
                subclass: AMINOGLYCOSIDE -> GENTAMICIN

- AMR HMM library Changes:
                  Total:  Added           6
                  Total:  Prev. Release   620
                  Total:  Removed         1
                  Total:  This Release    625
            HMM Removed:  NF000242.1      macrolide_MphB-NCBI
              HMM Added:  NF000242.2      macrolide_MphB-NCBI
              HMM Added:  NF033862.2      polymyxin_MCR10-NCBI
              HMM Added:  NF038046.1      blaCVI-NCBI
              HMM Added:  NF038056.1      macrolide_MphM-NCBI
              HMM Added:  NF038057.1      macrolide_MphL-NCBI
              HMM Added:  NF038069.1      blaIDC-NCBI

- Protein family changes:
                  Total:  Added           32
                  Total:  Prev. Release   1536
                  Total:  Removed         1
                  Total:  This Release    1567
         Family Removed:  -               aac(3)-IV
           Family Added:  -               aac(3)-IIb
           Family Added:  -               aac(3)-IIc
           Family Added:  -               aac(3)-IId
           Family Added:  -               aac(3)-Ia
           Family Added:  -               aac(3)-Ib
           Family Added:  -               aac(3)-Ic
           Family Added:  -               aac(3)-Id
           Family Added:  -               aac(3)-If
           Family Added:  -               aac(3)-Ig
           Family Added:  -               aac(3)-Ih
           Family Added:  -               aac(3)-Ii
           Family Added:  -               aac(6')-Ib-AGKT
           Family Added:  -               aac(6')-Ib-AKT
           Family Added:  -               aac(6')-Ib-D181Y
           Family Added:  -               aac(6')-Ib-G
           Family Added:  -               aac(6')-Ib-K
           Family Added:  -               aac(6')-Ib-KT
           Family Added:  -               aac(6')-Ib-W104R
           Family Added:  -               aac(6')-Ib-generic
           Family Added:  -               abaF
           Family Added:  -               almG
           Family Added:  -               ant(3'')-Ij
           Family Added:  NF038046.1      blaCVI
           Family Added:  NF038069.1      blaIDC
           Family Added:  -               blaPNGM
           Family Added:  -               blaRSA2
           Family Added:  -               blaRSC1
           Family Added:  -               blaRSD1
           Family Added:  -               blaRSD2
           Family Added:  -               catB8j
           Family Added:  -               papF
           Family Added:  -               tet(55)
         Family Changed:  - mcr-10        updated to NF033862.2 mcr-10
         Family Changed:  NF000242.1 mph(B) updated to NF000242.2 mph(B)
         Family Changed:  - mphL          updated to NF038057.1 mphL
         Family Changed:  - mphM          updated to NF038056.1 mphM


----------------------------------------------------------------------
Changes included in 2020-01-22.1
----------------------------------------------------------------------

This release includes a renaming of the gene symbols for stx to conform to the
Scheutz et al., 2012 (pmid: 22760050), new AMR alleles, and five new virulence
factor genes.

- Reference Gene Catalog changes (proteins and point mutations):
          Total in prev:  6622
       Total in release:  6672
                Removed:  0
                  Added:  50
                Changed:  118
                   Added  espB AAC38396.1
                   Added  fdeC ABE05822.1
                   Added  espX1 ADD54679.1
                   Added  iucA EGI25746.1
                   Added  fosA7.5 WP_000941933.1
                   Added  fosA7.2 WP_000941935.1
                   Added  blaADC-226 WP_001211224.1
                   Added  blaB-19 WP_019051344.1
                   Added  blaB-17 WP_021348010.1
                   Added  fosA7.4 WP_023216493.1
                   Added  fosA7.3 WP_023231494.1
                   Added  blaB-21 WP_029728367.1
                   Added  blaADC-233 WP_031950434.1
                   Added  blaADC-222 WP_031960999.1
                   Added  fosA7.7 WP_058653118.1
                   Added  fosA7.6 WP_061377147.1
                   Added  blaADC-232 WP_064907116.1
                   Added  blaADC-224 WP_064907831.1
                   Added  blaADC-223 WP_064987478.1
                   Added  blaB-26 WP_065083535.1
                   Added  blaB-33 WP_065161001.1
                   Added  blaB-22 WP_068801164.1
                   Added  blaB-23 WP_069214019.1
                   Added  blaB-31 WP_078675249.1
                   Added  blaB-18 WP_078691467.1
                   Added  blaB-25 WP_078702010.1
                   Added  blaB-24 WP_078704370.1
                   Added  blaB-32 WP_078723747.1
                   Added  blaB-35 WP_078793100.1
                   Added  blaB-38 WP_078795346.1
                   Added  fosA7.8 WP_079820715.1
                   Added  blaGOB-19 WP_086979105.1
                   Added  blaB-16 WP_086980232.1
                   Added  blaB-20 WP_101360538.1
                   Added  cfr(D) WP_105459893.1
                   Added  blaCTX-M-154 WP_110093562.1
                   Added  blaKPC-52 WP_158208806.1
                   Added  blaKPC-51 WP_158208923.1
                   Added  blaADC-225 WP_160164833.1
                   Added  blaADC-227 WP_160164834.1
                   Added  blaADC-228 WP_160164835.1
                   Added  blaADC-229 WP_160164836.1
                   Added  blaADC-230 WP_160164837.1
                   Added  blaADC-231 WP_160164838.1
                   Added  blaKPC-54 WP_160164839.1
                   Added  blaVEB-25 WP_160164840.1
                   Added  mcr-1.23 WP_160164897.1
                   Added  mcr-1.24 WP_160164898.1
                   Added  mcr-1.25 WP_160164899.1
                   Added  iroE YP_002527501.1
  Changes:
     stxA2b AAA16360.1
                gene_family                    stx2Ab -> stxA2b
     stxB2b AAA16361.1
                gene_family                    stx2Bb -> stxB2b
     stxA2c AAA16362.1
                gene_family                    stx2Ac -> stxA2c
     stxA2e AAA19189.1
                gene_family                    stx2Ae -> stxA2e
     stxB2e AAA19190.1
                gene_family                    stx2Be -> stxB2e
     stxA2f AAA24632.1
                gene_family                    stx2Af -> stxA2f
     stxB2f AAA24633.1
                gene_family                    stx2Bf -> stxB2f
     stxA1a AAA71893.1
                gene_family                    stx1Aa -> stxA1a
     stxB1a AAA71894.1
                gene_family                    stx1Ba -> stxB1a
     stxA1a AAA98099.1
                gene_family                    stx1Aa -> stxA1a
     stxA2e AAC45964.1
                gene_family                    stx2Ae -> stxA2e
     stxB2e AAC45965.1
                gene_family                    stx2Be -> stxB2e
     stxA2b AAD12174.1
                gene_family                    stx2Ab -> stxA2b
     stxA2c AAG01033.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d AAK66972.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAM22256.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d AAM22257.1
                gene_family                    stx2Bd -> stxB2d
     stxA2a AAM70045.1
                gene_family                    stx2Aa -> stxA2a
     stxA2d AAM88302.1
                gene_family                    stx2Ad -> stxA2d
     stxB2a AAM90978.1
                gene_family                    stx2Ba -> stxB2a
     stxA2d AAN77057.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAN77061.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAN77063.1
                gene_family                    stx2Ad -> stxA2d
     stxA1d AAO19475.1
                gene_family                    stx1Ad -> stxA1d
     stxB1d AAO19476.1
                gene_family                    stx1Bd -> stxB1d
     stxA2g AAP37403.1
                gene_family                    stx2Ag -> stxA2g
     stxA2e AAQ17546.1
                gene_family                    stx2Ae -> stxA2e
     stxA2c AAS07580.1
                gene_family                    stx2Ac -> stxA2c
     stxB2c AAS07581.1
                gene_family                    stx2Bc -> stxB2c
     stxA2c AAS07582.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d AAS07586.1
                gene_family                    stx2Ad -> stxA2d
     stxA2d AAS07588.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d AAS07589.1
                gene_family                    stx2Bd -> stxB2d
     stxA2c AAS07590.1
                gene_family                    stx2Ac -> stxA2c
     stxA2c AAS07596.1
                gene_family                    stx2Ac -> stxA2c
     stxA2a AAS07600.1
                gene_family                    stx2Aa -> stxA2a
     stxA2a AAS07606.1
                gene_family                    stx2Aa -> stxA2a
     stxA2c AAT65972.1
                gene_family                    stx2Ac -> stxA2c
     stxA2c AAT66000.1
                gene_family                    stx2Ac -> stxA2c
     stxA2a AAT66010.1
                gene_family                    stx2Aa -> stxA2a
     stxB2a AAT66011.1
                gene_family                    stx2Ba -> stxB2a
     stxA2c AAT66012.1
                gene_family                    stx2Ac -> stxA2c
     stxA2c AAU88208.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d AAY63864.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d AAY63865.1
                gene_family                    stx2Bd -> stxB2d
     stxA2c ABB36584.1
                gene_family                    stx2Ac -> stxA2c
     stxA2d ABB36586.1
                gene_family                    stx2Ad -> stxA2d
     stxA2a ABC67318.2
                gene_family                    stx2Aa -> stxA2a
     stxB2a ABR09925.1
                gene_family                    stx2Ba -> stxB2a
     stxA2c ABR09934.1
                gene_family                    stx2Ac -> stxA2c
     stxB2c ABR09935.1
                gene_family                    stx2Bc -> stxB2c
     stxA2d ABR09936.1
                gene_family                    stx2Ad -> stxA2d
     stxB2d ABR09937.1
                gene_family                    stx2Bd -> stxB2d
     stxB2a ABR09945.1
                gene_family                    stx2Ba -> stxB2a
     stxB2a ABR09961.1
                gene_family                    stx2Ba -> stxB2a
     stxB2a ABR09963.1
                gene_family                    stx2Ba -> stxB2a
     stxA2b ABR10024.1
                gene_family                    stx2Ab -> stxA2b
     stxA2c ABU55302.1
                gene_family                    stx2Ac -> stxA2c
     stxA2a ACU32684.1
                gene_family                    stx2Aa -> stxA2a
     stxA2b BAA77749.1
                gene_family                    stx2Ab -> stxA2b
     stxB2b BAA77750.1
                gene_family                    stx2Bb -> stxB2b
     stxA2b BAA77751.1
                gene_family                    stx2Ab -> stxA2b
     stxA2c BAB68369.1
                gene_family                    stx2Ac -> stxA2c
     stxB2c BAB68370.1
                gene_family                    stx2Bc -> stxB2c
     stxA2b BAB82994.1
                gene_family                    stx2Ab -> stxA2b
     stxA2b BAB82996.1
                gene_family                    stx2Ab -> stxA2b
     stxA2b BAB82998.1
                gene_family                    stx2Ab -> stxA2b
     stxA2b BAB83000.1
                gene_family                    stx2Ab -> stxA2b
     stxA2g BAB83002.1
                gene_family                    stx2Ag -> stxA2g
     stxB2g BAB83003.1
                gene_family                    stx2Bg -> stxB2g
     stxB2b BAB83005.1
                gene_family                    stx2Bb -> stxB2b
     stxB2b BAB83007.1
                gene_family                    stx2Bb -> stxB2b
     stxA2g BAB83020.1
                gene_family                    stx2Ag -> stxA2g
     stxA1c BAB83022.1
                gene_family                    stx1Ac -> stxA1c
     stxB1c BAB83023.1
                gene_family                    stx1Bc -> stxB1c
     stxA2b BAB83024.1
                gene_family                    stx2Ab -> stxA2b
     stxA1c BAC10987.1
                gene_family                    stx1Ac -> stxA1c
     stxB1c BAC10988.1
                gene_family                    stx1Bc -> stxB1c
     stxB1c BAC10992.1
                gene_family                    stx1Bc -> stxB1c
     stxA1a BAC78639.1
                gene_family                    stx1Aa -> stxA1a
     stxB1a BAC78640.1
                gene_family                    stx1Ba -> stxB1a
     stxA2f BAH86759.1
                gene_family                    stx2Af -> stxA2f
     stxB2f BAH86760.1
                gene_family                    stx2Bf -> stxB2f
     stxA2c CAA30714.1
                gene_family                    stx2Ac -> stxA2c
     stxB2a CAA30715.1
                gene_family                    stx2Ba -> stxB2a
     stxA2d CAA43585.1
                gene_family                    stx2Ad -> stxA2d
     stxA2b CAA46767.1
                gene_family                    stx2Ab -> stxA2b
     stxB2b CAA46768.1
                gene_family                    stx2Bb -> stxB2b
     stxA2e CAA57171.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAA57173.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAA57175.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAA57177.1
                gene_family                    stx2Ae -> stxA2e
     stxA1a CAA85366.1
                gene_family                    stx1Aa -> stxA1a
     stxA1a CAA85368.1
                gene_family                    stx1Aa -> stxA1a
     stxA1c CAA85370.1
                gene_family                    stx1Ac -> stxA1c
     stxB1c CAA85371.1
                gene_family                    stx1Bc -> stxB1c
     stxA2a CAA85780.1
                gene_family                    stx2Aa -> stxA2a
     stxA2a CAA90630.1
                gene_family                    stx2Aa -> stxA2a
     stxA2f CAB64953.1
                gene_family                    stx2Af -> stxA2f
     stxA2e CAB77169.2
                gene_family                    stx2Ae -> stxA2e
     stxB2a CAB94149.1
                gene_family                    stx2Ba -> stxB2a
     stxA2b CAC48396.1
                gene_family                    stx2Ab -> stxA2b
     stxA2e CAC48398.1
                gene_family                    stx2Ae -> stxA2e
     stxA2g CAI91198.1
                gene_family                    stx2Ag -> stxA2g
     stxA1a CAJ76690.1
                gene_family                    stx1Aa -> stxA1a
     stxA1a CAJ76692.1
                gene_family                    stx1Aa -> stxA1a
     stxA2e CAP17609.1
                gene_family                    stx2Ae -> stxA2e
     stxB2e CAP17610.1
                gene_family                    stx2Be -> stxB2e
     stxA2c CAQ68302.1
                gene_family                    stx2Ac -> stxA2c
     stxA2e CAX45702.1
                gene_family                    stx2Ae -> stxA2e
     stxA2d CAX45706.1
                gene_family                    stx2Ad -> stxA2d
     stxA2e CAX45714.1
                gene_family                    stx2Ae -> stxA2e
     stxA2e CAX45718.1
                gene_family                    stx2Ae -> stxA2e
     stxB2d CAX45737.1
                gene_family                    stx2Bd -> stxB2d
     stxB2a CAX45739.1
                gene_family                    stx2Ba -> stxB2a
     stxA2c CAX45746.1
                gene_family                    stx2Ac -> stxA2c
     stxA2e CAX51714.1
                gene_family                    stx2Ae -> stxA2e
     blaFOX-4 WP_032489727.1
                product_name                   cephalosporin-hydrolyzing class C beta-lactamase FOX-4 -> inhbitor-resistant cephalosporin-hydrolyzing class C beta-lactamase FOX-4
- AMR HMM library Changes:
                  Total:  Added           1
                  Total:  Prev. Release   620
                  Total:  Removed         0
                  Total:  This Release    621
              HMM Added:  NF033423.1      linco_LnuA-NCBI
           HMM Modified:  NF033639.1 linco_LnuA-NCBI updated to NF033639.1 inverse_SinH-NCBI
- Protein family changes:
                  Total:  Added           6
                  Total:  Prev. Release   1530
                  Total:  Removed         0
                  Total:  This Release    1536
         Family Renamed:  NF033658.1      stx1A  -> stxA1
         Family Renamed:  -               stx1Aa -> stxA1a
         Family Renamed:  -               stx1Ac -> stxA1c
         Family Renamed:  -               stx1Ad -> stxA1d
         Family Renamed:  NF033659.0      stx1B  -> stxB1
         Family Renamed:  -               stx1Ba -> stxB1a
         Family Renamed:  -               stx1Bc -> stxB1c
         Family Renamed:  -               stx1Bd -> stxB1d
         Family Renamed:  NF033661.1      stx2A  -> stxA2
         Family Renamed:  -               stx2Aa -> stxA2a
         Family Renamed:  -               stx2Ab -> stxA2b
         Family Renamed:  -               stx2Ac -> stxA2c
         Family Renamed:  -               stx2Ad -> stxA2d
         Family Renamed:  -               stx2Ae -> stxA2e
         Family Renamed:  -               stx2Af -> stxA2f
         Family Renamed:  -               stx2Ag -> stxA2g
         Family Renamed:  NF033660.0      stx2B  -> stxB2
         Family Renamed:  -               stx2Ba -> stxB2a
         Family Renamed:  -               stx2Bb -> stxB2b
         Family Renamed:  -               stx2Bc -> stxB2c
         Family Renamed:  -               stx2Bd -> stxB2d
         Family Renamed:  -               stx2Be -> stxB2e
         Family Renamed:  -               stx2Bf -> stxB2f
         Family Renamed:  -               stx2Bg -> stxB2g
           Family Added:  -               cfr(D)
           Family Added:  -               espX1
           Family Added:  -               fdeC
           Family Added:  -               iroE
           Family Added:  -               iucA
           Family Added:  NF033423.1      sinH

---------------------------------------------------------------------
Changes included in 2020-01-06.1
---------------------------------------------------------------------

This update includes backward incompatible changes to the AMRFinderPlus
database format. It is compatible with AMRFinderPlus version 3.6. To use
this database version please update to AMRFinderPlus version 3.6.
See https://github.com/ncbi/amr/wiki/Upgrading for how to upgrade and
https://github.com/evolarjun/amr/wiki/AMRFinderPlus-database for information
on the new database format.

Some highlights:

- Database format has changed to allow AMRFinderPlus to detect promoter mutations and small indels

- Many new point mutations, including Escherichia ampC promoter mutations, Klebsiella, and Enterococcus mutations

- Small improvements to many product names

- Improvements in class and subclass phenotype designations

- Modifications and additions of a few HMMs

- The usual addition of new alleles submitted to NCBI and others gleaned from the
literature



- Protein and point mutations:
          Total in prev: 6443
       Total in release: 6622
                Removed: 0
                  Added: 184
          Protein Added:  ABV01310.1      ltcA            heat-labile_enterotoxin_LT_subunit_A
          Protein Added:  ADE89421.1      sslE            lipoprotein_metalloprotease_SslE
          Protein Added:  ASK37426.1      aar             AggR-activated_transcriptional_regulator_Aar
          Protein Added:  BAB41547.1      mepA            multidrug_efflux_MATE_transporter_MepA
          Protein Added:  WP_000378442.1  emrR            multidrug_efflux_transporter_EmrAB_transcriptional_repressor_EmrR
          Protein Added:  WP_001132507.1  acrB            multidrug_efflux_RND_transporter_permease_subunit_AcrB
          Protein Added:  WP_002289153.1  liaR            response_regulator_transcription_factor_LiaR
          Protein Added:  WP_002289154.1  liaS            sensor_histidine_kinase_LiaS
          Protein Added:  WP_002289473.1  cls             cardiolipin_synthase_Cls
          Protein Added:  WP_002295408.1  liaF            three-component_signaling_pathway_regulator_LiaF
          Protein Added:  WP_002355137.1  liaR            response_regulator_transcription_factor_LiaR
          Protein Added:  WP_002356022.1  yybT            cyclic_dinucleotide_phosphodiesterase_YybT
          Protein Added:  WP_002365182.1  liaS            sensor_histidine_kinase_LiaS
          Protein Added:  WP_002371880.1  parC            DNA_topoisomerase_IV_subunit_A_ParC
          Protein Added:  WP_002381168.1  liaF            three-component_signaling_pathway_regulator_LiaF
          Protein Added:  WP_002389492.1  gshF            bifunctional_glutamate--cysteine_ligase/glutathione_synthetase_GshF
          Protein Added:  WP_002413481.1  cls             cardiolipin_synthase_Cls
          Protein Added:  WP_002895659.1  pmrA            two-component_system_response_regulator_PmrA
          Protein Added:  WP_002911375.1:47:mgrB_W47R mgrB            PhoP/PhoQ_regulator_MgrB
          Protein Added:  WP_004147969.1  phoQ            two-component_system_sensor_histidine_kinase_PhoQ
          Protein Added:  WP_004150807.1  phoP            two-component_system_response_regulator_PhoP
          Protein Added:  WP_004179093.1  pmrB            two-component_system_sensor_histidine_kinase_PmrB
          Protein Added:  WP_004184324.1  crrB            HAMP_domain-containing_histidine_kinase_CrrB
          Protein Added:  WP_014906821.1  arnC            undecaprenyl-phosphate_4-deoxy-4-formamido-L-arabinose_transferase_ArnC
          Protein Added:  WP_033554192.1  parE            DNA_topoisomerase_IV_subunit_B_ParE
          Protein Added:  WP_033785346.1  gyrA            DNA_gyrase_subunit_A_GyrA
          Protein Added:  WP_048324114.1  blaOKP-B-45     class_A_broad-spectrum_beta-lactamase_OKP-B-45
          Protein Added:  WP_049003700.1  blaOKP-B-41     class_A_broad-spectrum_beta-lactamase_OKP-B-41
          Protein Added:  WP_057012521.1  blaPFM-2        subclass_B2_metallo-beta-lactamase_PFM-2
          Protein Added:  WP_060573544.1  blaACT-77       cephalosporin-hydrolyzing_class_C_beta-lactamase_ACT-77
          Protein Added:  WP_060655783.1  blaOKP-B-36     class_A_broad-spectrum_beta-lactamase_OKP-B-36
          Protein Added:  WP_064183695.1  blaOKP-B-16     class_A_broad-spectrum_beta-lactamase_OKP-B-16
          Protein Added:  WP_080897395.1  blaOKP-D-1      class_A_broad-spectrum_beta-lactamase_OKP-D-1
          Protein Added:  WP_086259262.1  acrB            multidrug_efflux_RND_transporter_permease_subunit_AcrB
          Protein Added:  WP_087771722.1  blaOKP-B-34     class_A_broad-spectrum_beta-lactamase_OKP-B-34
          Protein Added:  WP_087833272.1  blaOKP-B-21     class_A_broad-spectrum_beta-lactamase_OKP-B-21
          Protein Added:  WP_100886243.1  blaOXA-895      OXA-229_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-895
          Protein Added:  WP_101982161.1  parC            DNA_topoisomerase_IV_subunit_A_ParC
          Protein Added:  WP_114508147.1  blaOKP-B-40     class_A_broad-spectrum_beta-lactamase_OKP-B-40
          Protein Added:  WP_115256011.1  parC            DNA_topoisomerase_IV_subunit_A_ParC
          Protein Added:  WP_117036963.1  gyrA            DNA_gyrase_subunit_A_GyrA
          Protein Added:  WP_122543028.1  blaOKP-B-22     class_A_broad-spectrum_beta-lactamase_OKP-B-22
          Protein Added:  WP_125353308.1  qnrB96          quinolone_resistance_pentapeptide_repeat_protein_QnrB96
          Protein Added:  WP_130202201.1  blaVIM-69       subclass_B1_metallo-beta-lactamase_VIM-69
          Protein Added:  WP_131419583.1  blaTEM-238      class_A_beta-lactamase_TEM-238
          Protein Added:  WP_136034107.1  blaOKP-C-1      class_A_broad-spectrum_beta-lactamase_OKP-C-1
          Protein Added:  WP_137277832.1  gyrA            DNA_gyrase_subunit_A_GyrA
          Protein Added:  WP_156404644.1  blaADC-221      class_C_beta-lactamase_ADC-221
          Protein Added:  WP_156404645.1  blaCMH-6        class_C_beta-lactamase_CMH-6
          Protein Added:  WP_156404646.1  blaCMY-168      class_C_beta-lactamase_CMY-168
          Protein Added:  WP_156404647.1  blaCMY-169      class_C_beta-lactamase_CMY-169
          Protein Added:  WP_156404648.1  blaCMY-170      class_C_beta-lactamase_CMY-170
          Protein Added:  WP_156404649.1  blaCTX-M-143    class_A_extended-spectrum_beta-lactamase_CTX-M-143
          Protein Added:  WP_156404650.1  blaCTX-M-230    class_A_extended-spectrum_beta-lactamase_CTX-M-230
          Protein Added:  WP_156404651.1  blaCTX-M-231    class_A_extended-spectrum_beta-lactamase_CTX-M-231
          Protein Added:  WP_156404652.1  blaCTX-M-232    class_A_extended-spectrum_beta-lactamase_CTX-M-232
          Protein Added:  WP_156404653.1  blaCTX-M-233    class_A_extended-spectrum_beta-lactamase_CTX-M-233
          Protein Added:  WP_156404654.1  blaMOX-14       CMY-1/MOX_family_class_C_beta-lactamase_MOX-14
          Protein Added:  WP_156404655.1  blaNDM-26       subclass_B1_metallo-beta-lactamase_NDM-26
          Protein Added:  WP_156404656.1  blaNDM-29       subclass_B1_metallo-beta-lactamase_NDM-29
          Protein Added:  WP_156404657.1  blaOKP-B-24     class_A_broad-spectrum_beta-lactamase_OKP-B-24
          Protein Added:  WP_156404658.1  blaOXA-896      class_D_beta-lactamase_OXA-896
          Protein Added:  WP_156404659.1  blaPER-14       class_A_extended-spectrum_beta-lactamase_PER-14
          Protein Added:  WP_156404660.1  blaPFM-3        subclass_B2_metallo-beta-lactamase_PFM-3
          Protein Added:  WP_156404661.1  blaSHV-115      class_A_extended-spectrum_beta-lactamase_SHV-115
          Protein Added:  WP_156404662.1  blaVEB-23       class_A_extended-spectrum_beta-lactamase_VEB-23
          Protein Added:  WP_156404663.1  blaVEB-24       class_A_extended-spectrum_beta-lactamase_VEB-24

Changes to existing protein and point mutation records:
Changed mepA accesssion: Q7A7N0.1 -> BAB41547.1
 Changed ltcA accession: ABV01314.1 -> ABV01310.1
  Changed aar accession: AVL28824.1 -> ASK37426.1
Changed reference sequence for Escherichia parE point mutations: WP_000195296.1 -> WP_033554192.1
Changed reference sequence for Escherichia acrB point mutations: WP_097509477.1 -> WP_086259262.1

     16S_A1055G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1408G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
                subclass                       AMINOGLYCOSIDE -> GENTAMICIN C/NEOMYCIN/PAROMOMYCIN
     16S_A1499G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1519C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1519G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A1519T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A523C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A794G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A794T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_A964G NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1054T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1065T NC_003197.2
                genbank_nucleotide_accession    -> AE006468.2
                genbank_strand_orientation      -> +
     16S_C1066T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1192T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_C1192T NC_003197.2
                genbank_nucleotide_accession    -> AE006468.2
                genbank_strand_orientation      -> +
     16S_C528T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1053A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1058C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1064A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
                subclass                       KANAMYCIN -> SPECTINOMYCIN
     16S_G1064C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1064T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G1068A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G527T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G926A NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G926C NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_G926T NC_000913.3
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
     16S_T1406A NC_000913.3
                class                          AMINOGLYCOSIDE -> AMINGLYCOSIDE
                genbank_nucleotide_accession    -> U00096.3
                genbank_strand_orientation      -> +
                subclass                       G418 -> G418/TOBRAMYCIN
     23S_A2058G NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TELITHROMYCIN
     23S_A2058T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> AZITHROMYCIN/ERYTHROMYCIN/TELITHROMYCIN
     23S_A2074C NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_A2074G NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_A2074T NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_A2075G NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_C2611T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> ERYTHROMYCIN/TELITHROMYCIN
     23S_C2627A NC_002163.1
                genbank_nucleotide_accession    -> AL111168.1
                genbank_strand_orientation      -> +
     23S_G2032A NC_004431.1
                class                          MACROLIDE/OXAZOLIDINONE -> LINCOSAMIDE/OXAZOLIDINONE
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE/OXAZOLIDINONE -> CLINDAMYCIN/LINEZOLID
     23S_G2032C NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       OXAZOLIDINONE -> LINEZOLID
     23S_G2032T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE/OXAZOLIDINONE -> CLARITHROMYCIN/LINEZOLID
     23S_G2057A NC_004431.1
                class                          MACROLIDE/PHENICOL -> MULTIDRUG
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE/CHLORAMPHENICOL -> CHLORAMPHENICOL/ERYTHROMYCIN/TELITHROMYCIN
     23S_G2447T NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       OXAZOLIDINONE -> LINEZOLID
     23S_T754A NC_004431.1
                genbank_nucleotide_accession    -> AE014075.1
                genbank_strand_orientation      -> +
                subclass                       MACROLIDE -> ERYTHROMYCIN/TELITHROMYCIN
     50S_L22_A103C WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_A103V WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_A103V WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_A84D WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_A84D WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_A88E WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_A88E WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_G86E WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_G86E WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     50S_L22_G86V WP_002779996.1
                genbank_protein_accession       -> AJW59082.1
     50S_L22_G86V WP_002851214.1
                genbank_protein_accession       -> CAL35796.1
     astA AAA20885.1
                class                          VIRULENCE ->
                subclass                       astA ->
     arsB AAA21095.1
                blacklisted_taxa               Escherichia ->
     arsC AAA21096.1
                blacklisted_taxa               Escherichia ->
     arsB AAA25637.1
                blacklisted_taxa               Staphylococcus ->
     arsB AAA27588.1
                blacklisted_taxa               Staphylococcus ->
     arsC AAB09628.1
                blacklisted_taxa               Escherichia ->
     ehxA AAC24352.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     astA AAD43578.1
                class                          VIRULENCE ->
                subclass                       astA ->
     astA AAD43579.1
                class                          VIRULENCE ->
                subclass                       astA ->
     astA AAM88299.1
                class                          VIRULENCE ->
                subclass                       astA ->
     ehxA AAZ76497.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02442.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02443.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02445.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02447.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     ehxA ABQ02448.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     emrD3 ABQ18953.1
                blacklisted_taxa               Vibrio_cholerae ->
     kdeA ABR76310.1
                blacklisted_taxa               Klebsiella ->
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     ehxA ACL51961.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     emrD ACN65732.1
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     amvA ACQ82816.1
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     astA ADI59685.1
                class                          VIRULENCE ->
                subclass                       astA ->
     ehxA ADZ45128.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     asr BAA15331.2
                blacklisted_taxa               Escherichia ->
     arsB BAA24823.1
                blacklisted_taxa               Escherichia ->
     arsC BAA24824.1
                blacklisted_taxa               Escherichia, Klebsiella ->
     ehxA BAA31774.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     fieF BAB89353.1
                blacklisted_taxa               Klebsiella ->
     fieF BAE77395.1
                blacklisted_taxa               Escherichia, Salmonella ->
     emrD BAE77620.1
                blacklisted_taxa               Escherichia ->
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     arsR BAE77793.1
                blacklisted_taxa               Escherichia ->
     ehxA CAA63849.1
                product_name                   enterohemolysin -> enterohemolysin EhxA
     emrD EFF04178.1
                class                           -> EFFLUX
                subclass                        -> EFFLUX
     silF KGL71342.1
                product_name                   Ag(+)/Cu(+) efflux RND transporter periplasmic metallochaperone SilF -> Cu(+)/Ag(+) efflux RND transporter periplasmic metallochaperone SilF
     dfrA18 WP_001031075.1
                product_name                   trimethoprim-resistant dihydrofolate reductase Dfr18 -> trimethoprim-resistant dihydrofolate reductase DfrA18
     mphK WP_003246254.1
                product_name                   macrolide 2'-phosphotransferase MphJ -> macrolide 2'-phosphotransferase MphK
     blaOKP-B-6 WP_004205995.1
                gene_family                    blaOKP -> blaOKP-B
     ampC WP_006178946.1
                product_name                   CMY2/MIR/ACT/EC family class c beta-lactamase -> CMY2/MIR/ACT/EC family class C beta-lactamase
     blaOKP-B-8 WP_017900346.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-A-17 WP_023289605.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-23 WP_023318187.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-A-2 WP_032452758.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-1 WP_032456002.1
                gene_family                    blaOKP -> blaOKP-B
     blaPAC-1 WP_034051940.1
                product_name                   class C beta-lactamase PAC-1 -> inhibitior-resistant cephalosporin-hydrolyzing class C beta-lactamase PAC-1
                subclass                       BETA-LACTAM -> CEPHALOSPORIN
     blaOKP-A-3 WP_044522859.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-8 WP_048334865.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-7 WP_057215100.1
                gene_family                    blaOKP -> blaOKP-B
     ampC WP_057991970.1
                product_name                   class C beta-lactamase -> MCA family class C beta-lactamase
     blaOKP-A-6 WP_060590773.1
                gene_family                    blaOKP -> blaOKP-A
     ampC WP_063406924.1
                product_name                   CMY2/MIR/ACT/EC family class c beta-lactamase -> CMY2/MIR/ACT/EC family class C beta-lactamase
     blaOKP-B WP_063842745.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-A-1 WP_063860896.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-10 WP_063860897.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-11 WP_063860898.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-12 WP_063860899.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-13 WP_063860900.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-14 WP_063860901.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-15 WP_063860902.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-16 WP_063860903.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-4 WP_063860904.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-5 WP_063860905.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-7 WP_063860906.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-A-9 WP_063860907.1
                gene_family                    blaOKP -> blaOKP-A
     blaOKP-B-10 WP_063860908.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-11 WP_063860909.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-13 WP_063860910.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-17 WP_063860911.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-18 WP_063860912.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-19 WP_063860913.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-2 WP_063860914.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-20 WP_063860915.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-3 WP_063860916.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-4 WP_063860917.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-5 WP_063860923.1
                gene_family                    blaOKP -> blaOKP-B
     blaOKP-B-9 WP_063860931.1
                gene_family                    blaOKP -> blaOKP-B
     icr-Mo WP_082741435.1
                class                           -> COLISTIN
                subclass                        -> COLISTIN
     blaPDC-245 WP_100831609.1
                product_name                   class C beta-lactamase PDC-245 -> inhibitor-resistant class C beta-lactamase PDC-245
     blaPDC-270 WP_109791203.1
                product_name                   class C beta-lactamase PDC-270 -> inhibitor-resistant class C beta-lactamase PDC-270
     blaPDC-322 WP_138403314.1
                product_name                   class C beta-lactamase PDC-322 -> inhibitor-resistant class C beta-lactamase PDC-322
     blaKPC-41 WP_148044419.1
                product_name                   carbapenem-hydrolyzing class A beta-lactamase KPC-41 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-41
     blaPDC-346 WP_148044438.1
                product_name                   class C beta-lactamase PDC-346 -> inhibitor-resistant class C beta-lactamase PDC-346
     blaPDC-381 WP_148044467.1
                product_name                   class C beta-lactamase PDC-381 -> inhibitor-resistant class C beta-lactamase PDC-381
     acrR_R45C WP_000101737.1
                genbank_protein_accession       -> AAC73566.1
                product_name                   transcriptional regulator -> transcriptional regulator AcrR
     basR_G15R WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53A WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53C WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53E WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53R WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53S WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53V WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_G53W WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_L105P WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_R81L WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_R81S WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     basR_S39I WP_094970923.1
                genbank_protein_accession       -> OZX69954.1
     cmeR_G86A WP_002843095.1
                genbank_protein_accession       -> EAH9016342.1
     cyaA_S352T WP_000281668.1
                genbank_protein_accession       -> CDJ73082.1
                product_name                   adenylate cyclase -> adenylate cyclase CyaA
     fabG_Y151V WP_001718014.1
                genbank_protein_accession       -> EMW23334.1
                product_name                   beta-ketoacyl-ACP reductase -> beta-ketoacyl-ACP reductase FabG
     fabI_F203A WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_F203C WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_F203L WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_G93A WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_G93S WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     fabI_G93V WP_000506490.1
                genbank_protein_accession       -> AAC74370.1
     folP_P64A WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64H WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64L WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64R WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     folP_P64S WP_000764731.1
                genbank_protein_accession       -> GDV24718.1
                product_name                   dihydropteroate synthase -> dihydropteroate synthase FolP
     gyrA_A119E WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A119S WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A119V WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A131G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A196E WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A51V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A67P WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A67S WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A70T WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A84P WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_A84V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D72G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D82G WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D82G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D82N WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D85Y WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87G WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87G WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87H WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87K WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87N WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87N WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87Y WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D87Y WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90A WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90N WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90N WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90T WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90Y WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_D90Y WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_E139A WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81C WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81C WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81D WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81H WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_G81S WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_H80P WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_L98V WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_N57K WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_P104S WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_P104S WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_Q106H WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_Q106R WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83A WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83A WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83F WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83F WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83I WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83L WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83V WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83W WP_001281243.1
                genbank_protein_accession       -> AXO84158.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S83Y WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_S97P WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86A WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86A WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86I WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86I WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86K WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86K WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86V WP_002779062.1
                genbank_protein_accession       -> AJW58405.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_T86V WP_002857904.1
                genbank_protein_accession       -> CAL35145.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrA_V73I WP_001281271.1
                genbank_protein_accession       -> EAB4993534.1
                product_name                   DNA gyrase subunit A -> DNA gyrase subunit A GyrA
     gyrB_D426N WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_E466D WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_K447E WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
                subclass                       QUINOLONE -> NALIDIXIC ACID
     gyrB_R136C WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136E WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136G WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136H WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136I WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136L WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R136S WP_000072067.1
                genbank_protein_accession       -> BAE77595.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_R438L WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     gyrB_S464F WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
                subclass                       QUINOLONE -> CIPROFLOXACIN
     gyrB_S464Y WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
                subclass                       QUINOLONE -> CIPROFLOXACIN
     gyrB_Y421C WP_000072047.1
                genbank_protein_accession       -> AHP21689.1
                product_name                   DNA topoisomerase (ATP-hydrolyzing) subunit B -> DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
     lon_P403L WP_001295325.1
                genbank_protein_accession       -> EQY31068.1
     marR_A70T WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_E31STOP WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_I49S WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_L78M WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R73C WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R73S WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R77C WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R77L WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R94H WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_R94S WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_S3N WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_V45E WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     marR_V96E WP_000843414.1
                genbank_protein_accession       -> AAC74603.2
                product_name                   MarR family transcriptional regulator -> transcriptional regulator MarR
     murA_C115D WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_C115E WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_C115S WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_D396N WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     murA_L370I WP_000357259.1
                genbank_protein_accession       -> AIL15701.1
                product_name                   UDP-N-acetylglucosamine 1-carboxyvinyltransferase -> UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
     nfsA_G131D WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_K141STOP WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_Q44STOP WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R133S WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R15C WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R203C WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_R203L WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     nfsA_S33R WP_089631889.1
                genbank_protein_accession       -> OYN67948.1
                subclass                       NITROFURAN -> NITROFURANTOIN
     ompF_G141D WP_000977920.1
                genbank_protein_accession       -> AAC74015.1
                product_name                   outer membrane protein F -> outer membrane protein F OmpF
     ompF_G141E WP_000977920.1
                genbank_protein_accession       -> AAC74015.1
                product_name                   outer membrane protein F -> outer membrane protein F OmpF
     parC_A108T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_A108V WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_A56T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_A85T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_D111H WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84A WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84G WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84G WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84K WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84K WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_E84V WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_F60I WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_F60L WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_G78D WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_G78D WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_G78K WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S129P WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S57T WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80F WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80I WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80I WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80L WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80R WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80R WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_S80Y WP_001281881.1
                genbank_protein_accession       -> AAC76055.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_T66I WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parC_W106G WP_001281910.1
                genbank_protein_accession       -> EAW2725281.1
                product_name                   DNA topoisomerase IV subunit A -> DNA topoisomerase IV subunit A ParC
     parE_A499T WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_E454G WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_H462Y WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_M438I WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_S458P WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_V461G WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_V514G WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     parE_V521F WP_000195318.1
                genbank_protein_accession       -> ATQ05934.1
                product_name                   DNA topoisomerase IV subunit B -> DNA topoisomerase IV subunit B ParE
     pmrA_G15R WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_G53E WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_G53R WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_R81C WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrA_R81H WP_000697899.1
                genbank_protein_accession       -> EAB2345955.1
     pmrB_A159P WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_A159V WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_C84R WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_C84Y WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E121A WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E121K WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E121Q WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E166K WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_E166K WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_G206D WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_G206R WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_G206W WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L10P WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L10R WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L14F WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L14R WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L14S WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_L22P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_M186I WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_N130Y WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94L WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94Q WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94Q WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_P94S WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_R155P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_S124P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_S29R WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_S305R WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T147A WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T147P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T156M WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T156M WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T156P WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_T92A WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161G WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161G WP_001300761.1
                genbank_protein_accession       -> KHH69629.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161L WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     pmrB_V161M WP_001212189.1
                genbank_protein_accession       -> EAM5131532.1
                product_name                   two-component sensor histidine kinase -> two-component system sensor histidine kinase PmrB
     ptsI_V25I WP_000623140.1
                genbank_protein_accession       -> CDJ72759.1
                product_name                   phosphoenolpyruvate--protein phosphotransferase -> phosphoenolpyruvate--protein phosphotransferase PtsI
     ramR_E160D WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_G25A WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_M84I WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_R46P WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_T18P WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_T50P WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     ramR_Y59H WP_000113609.1
                genbank_protein_accession       -> ACH50230.1
                product_name                   TetR/AcrR family transcriptional regulator -> TetR/AcrR family transcriptional regulator RamR
     rpoB_H526Y WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_L533P WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_P564L WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_Q513L WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_Q513P WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_R529C WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_R529S WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_R687H WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_S531F WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_T563P WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpoB_V146F WP_000263098.1
                genbank_protein_accession       -> CSN35596.1
                product_name                   DNA-directed RNA polymerase subunit beta -> DNA-directed RNA polymerase subunit beta RpoB
     rpsL_K43R WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     rpsL_K88E WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     rpsL_K88Q WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     rpsL_K88R WP_057042458.1
                genbank_protein_accession       -> EAI0845362.1
                product_name                   30S ribosomal protein S12 -> 30S ribosomal protein S12 RpsL
     soxR_G121D WP_000412428.1
                genbank_protein_accession       -> AAC77033.1
     soxR_G121D WP_000412686.1
                genbank_protein_accession       -> CAD09250.1
     soxR_R20H WP_000412428.1
                genbank_protein_accession       -> AAC77033.1
     soxR_R20H WP_000412686.1
                genbank_protein_accession       -> CAD09250.1
     soxS_A12S WP_000019358.1
                genbank_protein_accession       -> AAC77032.1
     soxS_E52K WP_000019483.1
                genbank_protein_accession       -> AAL23089.1
     tufA_A376S WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_A376T WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_A376V WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_E379K WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_G317D WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_L121Q WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q125E WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q125K WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q125R WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Q330H WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R231C WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R231V WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R234F WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R234S WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_R334C WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_T335A WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Y161C WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Y161D WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     tufA_Y161N WP_000031783.1
                genbank_protein_accession       -> AAC76364.1
     uhpA_G97D WP_000633668.1
                genbank_protein_accession       -> CDJ73205.1
                product_name                   DNA-binding response regulator -> DNA-binding response regulator UhpA
     uhpT_E350Q WP_000879194.1
                genbank_protein_accession       -> CDJ73208.1
                product_name                   hexose phosphate transporter -> hexose phosphate transporter UhpT

- AMR HMM library Changes:
                  Total:  Added           2
                  Total:  Prev. Release   618
                  Total:  Removed         0
                  Total:  This Release    620
              HMM Added:  NF037973.1      myrA-NCBI
              HMM Added:  NF038003.1      blaPLA_ORN_TER-NCBI
           HMM Modified:  NF000389.2 blaPLA_ORN_TER-NCBI updated to NF000389.2 blaPFM-NCBI
           HMM Modified:  NF033560.1 myrA-NCBI updated to NF033560.1 metallo_SslE-NCBI

- Protein family changes:
                  Total:  Added           3
                  Total:  Prev. Release   1527
                  Total:  Removed         0
                  Total:  This Release    1530
           Family Added:  -               blaOKP-C
           Family Added:  -               blaOKP-D
           Family Added:  NF037973.1      sslE
         Family Changed:  - blaPFM        updated to NF038003.1 blaPFM

---------------------------------------------------------------------
Changes included in 2019-10-30.1
---------------------------------------------------------------------

This update includes backward incompatible changes to the AMRFinderPlus
database format. It is compatible with AMRFinderPlus version 3.2 and above.
To use this database version please update to AMRFinderPlus version 3.2. See
https://github.com/ncbi/amr/wiki/Upgrading for how to upgrade and
https://github.com/evolarjun/amr/wiki/AMRFinderPlus-database for information
on the new database format.

--organism / -O value Vibrio has been changed to Vibrio_cholerae because the
blacklisted genes are common only in Vibrio_cholerae.

Two erronious proteins have been removed, several HMMs have been added, and
many new AMR alleles and "plus" genes.

All HMM's have internal short names that have been changed to include a suffix
to indicate the source (e.g., NCBI, Resfams, TIGRFAMs).

Class and subclass have been defined for some parent families where they were
not before. These will only be visible in AMRFinderPlus results if there was a
novel sequence classified by AMRFinder above the level of the gene included in
the Reference Gene Catalog.

- Protein and point mutation changes:
          Total in prev:  6271
       Total in release:  6443
                Removed:  2
                  Added:  174
                Changed:  42
                 Removed  ltcA CAA23532.1
                 Removed  sdeA EEZ94110.1
                   Added  bmaE AAA23523.1
                   Added  papG-II AAA24293.1
                   Added  focG AAB20438.1
                   Added  cdtA AAF81760.1
                   Added  ibeA AAF98391.2
                   Added  iutA AAN45165.2
                   Added  sdeA AAS55383.1
                   Added  emrD ACN65732.1
                   Added  tcdR AJP10335.1
                   Added  tcdB AJP10336.1
                   Added  tcdE AJP10337.1
                   Added  tcdA AJP10339.1
                   Added  tcdC AJP10340.1
                   Added  sfaF ASJ31253.1
                   Added  emrD BAE77620.1
                   Added  papG-III CAA43558.1
                   Added  papA CAA43562.1
                   Added  papH CAA43563.1
                   Added  papC CAA43564.1
                   Added  papE CAA43568.1
                   Added  papG-I CAA43570.1
                   Added  afaC CAA54117.1
                   Added  afaC CAW30799.1
                   Added  cdtB CBE05858.1
                   Added  emrD EFF04178.1
                   Added  sfaF EIL44824.1
                   Added  papA ENA25238.1
                   Added  cvaC P22522.1
                   Added  mepA Q7A7N0.1
                   Added  blaOXA-856 WP_001021774.1
                   Added  blaOXA-847 WP_010793618.1
                   Added  blaOXA-851 WP_014603442.1
                   Added  tva(B) WP_014936356.1
                   Added  blaOXA-848 WP_019485147.1
                   Added  mcr-10.1 WP_023332837.1
                   Added  blaADC-212 WP_031975357.1
                   Added  blaADC-203 WP_032000414.1
                   Added  blaOXA-855 WP_032061328.1
                   Added  blaACT-74 WP_032652275.1
                   Added  blaOXA-846 WP_033989974.1
                   Added  blaOXA-850 WP_034006563.1
                   Added  blaADC-215 WP_039098799.1
                   Added  blaADC-216 WP_039211240.1
                   Added  blaADC-219 WP_039213353.1
                   Added  blaAQU-1 WP_042888870.1
                   Added  blaLEN-32 WP_043875313.1
                   Added  blaACT-75 WP_045347148.1
                   Added  blaCMY-137 WP_053390271.1
                   Added  blaADC-214 WP_060454527.1
                   Added  blaADC-217 WP_060470109.1
                   Added  blaLEN-42 WP_061154665.1
                   Added  fosA8 WP_063277905.1
                   Added  blaLEN-34 WP_072124806.1
                   Added  blaLEN-43 WP_074385924.1
                   Added  blaADC-218 WP_078216190.1
                   Added  blaADC-213 WP_078230092.1
                   Added  blaLEN-30 WP_080923375.1
                   Added  blaAXC-3 WP_081330264.1
                   Added  blaOXA-842 WP_087088911.1
                   Added  blaADC-220 WP_087876534.1
                   Added  blaLEN-55 WP_094917017.1
                   Added  blaAXC-2 WP_100505522.1
                   Added  blaLEN-41 WP_100675621.1
                   Added  blaLEN-12 WP_110196444.1
                   Added  blaOXA-854 WP_114158997.1
                   Added  blaADC-199 WP_114166683.1
                   Added  blaOXA-853 WP_114252036.1
                   Added  blaLEN-58 WP_117122976.1
                   Added  blaLEN-51 WP_123836928.1
                   Added  blaACT-76 WP_126817982.1
                   Added  blaADC-207 WP_130173437.1
                   Added  blaADC-194 WP_133972424.1
                   Added  blaOXA-822 WP_133973918.1
                   Added  blaPDC-319 WP_134254706.1
                   Added  blaLEN-39 WP_136026639.1
                   Added  blaLEN-40 WP_136049560.1
                   Added  blaLEN-38 WP_136086342.1
                   Added  blaPDC-322 WP_138403314.1
                   Added  blaOXA-894 WP_144376393.1
                   Added  blaADC-197 WP_150823452.1
                   Added  blaADC-198 WP_150823453.1
                   Added  blaADC-200 WP_150823454.1
                   Added  blaADC-201 WP_150823455.1
                   Added  blaADC-202 WP_150823456.1
                   Added  blaADC-204 WP_150823457.1
                   Added  blaADC-205 WP_150823458.1
                   Added  blaADC-206 WP_150823459.1
                   Added  blaADC-208 WP_150823460.1
                   Added  blaADC-209 WP_150823461.1
                   Added  blaADC-210 WP_150823462.1
                   Added  blaADC-211 WP_150823463.1
                   Added  blaAXC-4 WP_150823464.1
                   Added  blaAXC-5 WP_150823465.1
                   Added  blaCARB-51 WP_150823466.1
                   Added  blaCARB-52 WP_150823467.1
                   Added  blaEBR-3 WP_150823468.1
                   Added  blaIMP-65 WP_150823469.1
                   Added  blaOXA-838 WP_150823470.1
                   Added  blaOXA-839 WP_150823471.1
                   Added  blaOXA-840 WP_150823472.1
                   Added  blaOXA-841 WP_150823473.1
                   Added  blaOXA-843 WP_150823474.1
                   Added  blaOXA-844 WP_150823475.1
                   Added  blaOXA-845 WP_150823476.1
                   Added  blaOXA-849 WP_150823477.1
                   Added  blaPDC-318 WP_150823478.1
                   Added  blaPDC-320 WP_150823479.1
                   Added  blaPDC-321 WP_150823480.1
                   Added  blaPDC-323 WP_150823481.1
                   Added  blaPDC-324 WP_150823482.1
                   Added  blaPDC-325 WP_150823483.1
                   Added  blaPDC-326 WP_150823484.1
                   Added  blaPDC-327 WP_150823485.1
                   Added  blaPDC-328 WP_150823486.1
                   Added  blaPDC-329 WP_150823487.1
                   Added  blaPDC-330 WP_150823488.1
                   Added  blaPDC-331 WP_150823489.1
                   Added  blaPDC-332 WP_150823490.1
                   Added  blaPDC-384 WP_150823491.1
                   Added  blaPDC-385 WP_150823492.1
                   Added  blaPDC-386 WP_150823493.1
                   Added  blaPST-2 WP_150823494.1
                   Added  blaTEM-240 WP_150823495.1
                   Added  mcr-3.28 WP_150823496.1
                   Added  mcr-8.3 WP_150823497.1
                   Added  tva(A) WP_151874537.1
                   Added  blaACT-73 WP_152315464.1
                   Added  blaIMP-85 WP_152315465.1
                   Added  blaMIR-23 WP_152315466.1
                   Added  blaNDM-25 WP_152315467.1
                   Added  blaOXA-830 WP_152315468.1
                   Added  blaOXA-852 WP_152315469.1
                   Added  blaOXA-857 WP_152315470.1
                   Added  blaOXA-858 WP_152315471.1
                   Added  blaOXA-859 WP_152315472.1
                   Added  blaOXA-860 WP_152315473.1
                   Added  blaOXA-861 WP_152315474.1
                   Added  blaOXA-862 WP_152315475.1
                   Added  blaOXA-863 WP_152315476.1
                   Added  blaOXA-864 WP_152315477.1
                   Added  blaOXA-865 WP_152315478.1
                   Added  blaOXA-866 WP_152315479.1
                   Added  blaOXA-867 WP_152315480.1
                   Added  blaOXA-868 WP_152315481.1
                   Added  blaOXA-869 WP_152315482.1
                   Added  blaOXA-870 WP_152315483.1
                   Added  blaOXA-871 WP_152315484.1
                   Added  blaOXA-872 WP_152315485.1
                   Added  blaOXA-873 WP_152315486.1
                   Added  blaOXA-874 WP_152315487.1
                   Added  blaOXA-875 WP_152315488.1
                   Added  blaOXA-876 WP_152315489.1
                   Added  blaOXA-877 WP_152315490.1
                   Added  blaOXA-878 WP_152315491.1
                   Added  blaOXA-879 WP_152315492.1
                   Added  blaOXA-880 WP_152315493.1
                   Added  blaOXA-881 WP_152315494.1
                   Added  blaOXA-882 WP_152315495.1
                   Added  blaOXA-883 WP_152315496.1
                   Added  blaOXA-884 WP_152315497.1
                   Added  blaOXA-885 WP_152315498.1
                   Added  blaOXA-886 WP_152315499.1
                   Added  blaOXA-887 WP_152315500.1
                   Added  blaOXA-888 WP_152315501.1
                   Added  blaOXA-889 WP_152315502.1
                   Added  blaOXA-890 WP_152315503.1
                   Added  blaOXA-891 WP_152315504.1
                   Added  blaOXA-892 WP_152315505.1
                   Added  blaPDC-387 WP_152315506.1
                   Added  blaPDC-388 WP_152315507.1
                   Added  blaLEN-35 WP_152330887.1
                   Added  blaLEN-36 WP_152330888.1
                   Added  blaLEN-37 WP_152330889.1
                   Added  blaSHV-4 WP_152330890.1
  Changes:
     arsB AAA21095.1
                blacklisted_taxa                -> Escherichia
     arsC AAB09628.1
                blacklisted_taxa                -> Escherichia
     ymgB AAC74250.1
                subclass                       ACID ->
                subtype                        BIOCIDE -> ACID
     emrD3 ABQ18953.1
                blacklisted_taxa               Vibrio -> Vibrio_cholerae
     arsB BAA24823.1
                blacklisted_taxa                -> Escherichia
     fieF BAB89353.1
                blacklisted_taxa                -> Klebsiella
     aac(6')-I WP_002289795.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002293569.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002293989.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002328174.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002339746.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_002373947.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-Iih WP_005880220.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-Ii WP_008265821.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-Iid WP_010720790.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010723742.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010727362.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010728104.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010736157.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010737153.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010750427.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010752789.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_010768325.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_016172918.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_016177698.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_016628216.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_019722502.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_023519215.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_024635824.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_034688908.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_034700626.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_034860925.1
                gene_family                    aac(6') -> aac(6')-I
     blaOXA-252 WP_037428895.1
                curated_refseq_start           Yes -> No
                genbank_cds_start              842113 -> 2724286
                genbank_cds_stop               842910 -> 2725083
                genbank_nucleotide_accession   JTLE01000094.1 -> CP022089.2
                genbank_protein_accession       -> ASF15667.1
                genbank_strand_orientation     + -> -
                refseq_nucleotide_accession    NG_050608.1 -> NG_066509.1
     aac(6')-I WP_048603867.1
                gene_family                    aac(6') -> aac(6')-I
     aac(6')-I WP_053766315.1
                gene_family                    aac(6') -> aac(6')-I
     blaOXA-539 WP_071593233.1
                product_name                   OXA-2 family class D extended-spectrum beta-lactamase OXA-539 -> OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-539
                subclass                       BETA-LACTAM -> CEPHALOSPORIN
     lnu(F) WP_071846285.1
                allele                         linH2 ->
     aac(6')-I WP_071846353.1
                gene_family                    aac(6') -> aac(6')-I
     blaOXA-576 WP_087696200.1
                curated_refseq_start           Yes -> No
                genbank_cds_start              843910 -> 1
                genbank_cds_stop               844656 -> 747
                genbank_nucleotide_accession   NFPA01000015.1 -> MH085550.1
                genbank_protein_accession       -> AWD39715.1
                refseq_nucleotide_accession    NG_057458.1 -> NG_066510.1
     blaAQU WP_099156042.1
                allele                         blaAQU-1 ->
                product_name                   class C beta-lactamase AQU-1 -> AQU family class C beta-lactamase
     blaKPC-40 WP_115470049.1
                product_name                   carbapenem-hydrolyzing class A beta-lactamase KPC-40 -> inhibitor-resistant carbapenem-hydrolyzing class A beta-lactamase KPC-40
     blaOXA-681 WP_122630881.1
                product_name                   OXA-2 family class D beta-lactamase OXA-681 -> OXA-2 family inhibitor-resistant class D extended-spectrum beta-lactamase OXA-681
                subclass                       BETA-LACTAM -> CEPHALOSPORIN
- AMR HMM library Changes:
                  Total:  Added           10
                  Total:  Prev. Release   608
                  Total:  Removed         0
                  Total:  This Release    618
              HMM Added:                  154989_fosA-NCBI
              HMM Added:  NF000252.1      MsrSA-NCBI
              HMM Added:  NF000282.2      RPH_KJ151292.1-NCBI
              HMM Added:  NF000315.1      amicyc_ac_ApmA-NCBI
              HMM Added:  NF028537.1      QacCGHJ-NCBI
              HMM Added:  NF033086.2      penta_rpt_QnrA-NCBI
              HMM Added:  NF033134.0      cmlB1_MFS-NCBI
              HMM Added:  NF033643.1      FOX-MOX-NCBI
              HMM Added:  NF033651.1      dipept_VanX-NCBI
              HMM Added:  NF033653.1      blaOXA-274_like-NCBI
           HMM Modified:  NF000004.1 vanH-D updated to NF000004.1 vanH-Sc-NCBI
           HMM Modified:  NF000005.4 ble_BLMT updated to NF000005.4 ble_MBL-NCBI
           HMM Modified:  NF000006.2 trim_DfrA26 updated to NF000006.2 trim_DfrA3-NCBI
           HMM Modified:  NF000007.1 16S_rRNA_Rmt_D updated to NF000007.1 16S_rRNA_Rmt_E-NCBI
           HMM Modified:  NF000008.1 trim_DfrA1_rpt updated to NF000008.1 trim_DfrA20-NCBI
           HMM Modified:  NF000009.1 tet_MFS_Tcr3 updated to NF000009.1 tet_MFS_V-NCBI
           HMM Modified:  NF000010.1 AAC_2p_Ib updated to NF000010.1 AAC_2p_Ic-NCBI
           HMM Modified:  NF000011.2 APH_6_Ic updated to NF000011.2 APH_6_Ic_gen-NCBI
           HMM Modified:  NF000012.1 trim_DfrI updated to NF000012.1 vanH-Ac1-NCBI
           HMM Modified:  NF000013.1 tet_NaH_anti_35 updated to NF000013.1 tet_destruct-NCBI
           HMM Modified:  NF000014.1 tet_prtrans_34 updated to NF000014.1 tet_redox_37-NCBI
           HMM Modified:  NF000015.3 APH_2pp_IIa updated to NF000015.3 APH_2pp_I_a_f_h-NCBI
           HMM Modified:  NF000016.1 AAC_6p_Im updated to NF000016.1 AAC_6p_Ip-NCBI
           HMM Modified:  NF000017.1 linco_LnuD updated to NF000017.1 linco_LnuE-NCBI
           HMM Modified:  NF000018.2 trim_DfrA10 updated to NF000018.2 trim_DfrA12-NCBI
           HMM Modified:  NF000019.2 trim_DfrA3 updated to NF000019.2 trim_DfrA35-NCBI
           HMM Modified:  NF000020.1 stregram_VatE updated to NF000020.1 stregram_VatF-NCBI
           HMM Modified:  NF000021.4 AAC_6p_Serra updated to NF000021.4 AAC_6p_Steno-NCBI
           HMM Modified:  NF000022.1 stregra_B_VgbA updated to NF000022.1 stregra_B_VgbB-NCBI
           HMM Modified:  NF000023.1 qac_SMR_C updated to NF000023.1 qac_SMR_G-NCBI
           HMM Modified:  NF000024.1 ErmS updated to NF000024.1 ErmV-NCBI
           HMM Modified:  NF000025.1 MFS_efflux_tcmA updated to NF000025.1 MOX_CMY1_fam-NCBI
           HMM Modified:  NF000026.1 154989_fosA updated to NF000026.1 156720500_bleO-NCBI
           HMM Modified:  NF000027.1 156720500_bleO updated to NF000027.1 1567214_ble-NCBI
           HMM Modified:  NF000028.1 1567214_ble updated to NF000028.1 16S_rRNA_NpmA-NCBI
           HMM Modified:  NF000029.2 APH_9_Ib updated to NF000029.2 BlaA_Yent-NCBI
           HMM Modified:  NF000030.1 16S_rRNA_NpmA updated to NF000030.1 16S_rRNA_Rmt_B-NCBI
           HMM Modified:  NF000032.1 D_ala_D_ser_VanL updated to NF000032.1 D_ala_D_ser_VanN-NCBI
           HMM Modified:  NF000033.1 vanT-L-mem updated to NF000033.1 vanW-B-NCBI
           HMM Modified:  NF000034.1 AAC_2p_Ic updated to NF000034.1 AAC_2p_Id-NCBI
           HMM Modified:  NF000035.1 nosihep_NshR updated to NF000035.1 penta_rpt_Qnr-NCBI
           HMM Modified:  NF000036.1 D_ala_D_ser_VanE updated to NF000036.1 D_ala_D_ser_VanG-NCBI
           HMM Modified:  NF000037.1 RND_perm_OqxB updated to NF000037.1 RND_permease_1-NCBI
           HMM Modified:  NF000039.1 trim_DfrA18 updated to NF000039.1 trim_DfrA19-NCBI
           HMM Modified:  NF000041.1 trim_DfrA19 updated to NF000041.1 trim_DfrA1_like-NCBI
           HMM Modified:  NF000042.1 AAC_2p_Id updated to NF000042.1 AAC_2p_Ie-NCBI
           HMM Modified:  NF000043.1 tet_MFS_P_a updated to NF000043.1 tet_MFS_Tcr3-NCBI
           HMM Modified:  NF000044.2 APH_2pp_IIIa updated to NF000044.2 APH_2pp_IIa-NCBI
           HMM Modified:  NF000047.1 ErmV updated to NF000047.1 EspJ_gen-NCBI
           HMM Modified:  NF000048.1 AAC_6p_A40 updated to NF000048.1 AAC_6p_A48-NCBI
           HMM Modified:  NF000049.1 tet_MFS_40 updated to NF000049.1 tet_MFS_42-NCBI
           HMM Modified:  NF000050.2 AAC_6p_A29 updated to NF000050.2 AAC_6p_A30-NCBI
           HMM Modified:  NF000051.1 macrolide_MefB updated to NF000051.1 macrolide_MefC-NCBI
           HMM Modified:  NF000052.4 APH_9_Ia updated to NF000052.4 APH_9_Ib-NCBI
           HMM Modified:  NF000053.2 trim_DfrA12 updated to NF000053.2 trim_DfrA13_A21-NCBI
           HMM Modified:  NF000054.1 AAC_2p_Ie updated to NF000054.1 AAC_3-NCBI
           HMM Modified:  NF000055.3 trim_DfrA13_A21 updated to NF000055.3 trim_DfrA18-NCBI
           HMM Modified:  NF000056.3 penta_rpt_QnrS updated to NF000056.3 penta_rpt_QnrVC-NCBI
           HMM Modified:  NF000059.1 tet_redox_37 updated to NF000059.1 toxin_EAST1-NCBI
           HMM Modified:  NF000061.1 linco_LnuP updated to NF000061.1 lyase_MerB-NCBI
           HMM Modified:  NF000062.1 ANT_6_str updated to NF000062.1 ANT_9-NCBI
           HMM Modified:  NF000063.1 Fos_BSH_Sepi updated to NF000063.1 Fos_GSH-NCBI
           HMM Modified:  NF000064.3 ANT_2pp_Ia updated to NF000064.3 ANT_3pp_AadA1-NCBI
           HMM Modified:  NF000065.1 trim_DfrA3b updated to NF000065.1 trim_DfrA8-NCBI
           HMM Modified:  NF000066.1 rifampin_ARR_Sa updated to NF000066.1 sat2-NCBI
           HMM Modified:  NF000067.2 SMR_qac_FL updated to NF000067.2 SMR_qac_G2-NCBI
           HMM Modified:  NF000069.1 16S_rRNA_Rmt_E updated to NF000069.1 16S_rRNA_Rmt_F-NCBI
           HMM Modified:  NF000071.4 penta_rpt_QnrA updated to NF000071.4 penta_rpt_QnrAS-NCBI
           HMM Modified:  NF000072.1 MFS_efflux_PexA updated to NF000072.1 MFS_efflux_tcmA-NCBI
           HMM Modified:  NF000074.1 299782349_fosC updated to NF000074.1 299782351_fosA-NCBI
           HMM Modified:  NF000075.1 299782351_fosA updated to NF000075.1 354827590_fosA-NCBI
           HMM Modified:  NF000076.3 APH_2pp_Ie_IVa updated to NF000076.3 APH_2pp_If_Ih-NCBI
           HMM Modified:  NF000077.1 Erm42 updated to NF000077.1 Erm43-NCBI
           HMM Modified:  NF000079.1 ANT_4p_Ib updated to NF000079.1 ANT_6-NCBI
           HMM Modified:  NF000084.1 amicyc_ac_ApmA updated to NF000084.1 arsB_Sta_pI258-NCBI
           HMM Modified:  NF000085.1 Fos_BSH_Saur updated to NF000085.1 Fos_BSH_Sepi-NCBI
           HMM Modified:  NF000086.1 vanY_far updated to NF000086.1 vanY_of_D-NCBI
           HMM Modified:  NF000087.1 ErmO updated to NF000087.1 ErmS-NCBI
           HMM Modified:  NF000088.1 viomycin_Vph updated to NF000088.1 zbmA-NCBI
           HMM Modified:  NF000089.1 qac_MFS_AB updated to NF000089.1 qac_SMR_C-NCBI
           HMM Modified:  NF000090.1 trans_reg_VanU updated to NF000090.1 transloc_TIR-NCBI
           HMM Modified:  NF000091.3 D_ala_D_ser_VanG updated to NF000091.3 D_ala_D_ser_VanL-NCBI
           HMM Modified:  NF000092.1 D_ala_D_lac_Ao2 updated to NF000092.1 D_ala_D_lac_Sc-NCBI
           HMM Modified:  NF000093.1 D_ala_D_ser_VanN updated to NF000093.1 EreA-NCBI
           HMM Modified:  NF000094.1 354827590_fosA updated to NF000094.1 47473_otr-NCBI
           HMM Modified:  NF000095.1 tet_MFS_OtrB updated to NF000095.1 tet_MFS_P_a-NCBI
           HMM Modified:  NF000096.1 stregra_B_VgbB updated to NF000096.1 stregram_VatA-NCBI
           HMM Modified:  NF000097.1 stregram_VatC updated to NF000097.1 stregram_VatD-NCBI
           HMM Modified:  NF000098.1 Fos_BSH_Bcer updated to NF000098.1 Fos_BSH_Saur-NCBI
           HMM Modified:  NF000100.2 AAC_2p_IIa updated to NF000100.2 AAC_2p_IIb-NCBI
           HMM Modified:  NF000101.1 stregram_VatA updated to NF000101.1 stregram_VatC-NCBI
           HMM Modified:  NF000103.1 tet_ABC_AB_B updated to NF000103.1 tet_MFS_38-NCBI
           HMM Modified:  NF000107.2 APH_4_Ia updated to NF000107.2 APH_6-NCBI
           HMM Modified:  NF000108.1 AAC_2p_Ia updated to NF000108.1 AAC_2p_Ib-NCBI
           HMM Modified:  NF000109.2 trim_DfrA9 updated to NF000109.2 trim_DfrB-NCBI
           HMM Modified:  NF000110.2 AAC_6p_If updated to NF000110.2 AAC_6p_Il-NCBI
           HMM Modified:  NF000111.1 stregram_VatD updated to NF000111.1 stregram_VatE-NCBI
           HMM Modified:  NF000112.1 vanH-Amyco updated to NF000112.1 vanH-D-NCBI
           HMM Modified:  NF000113.1 16S_rRNA_Rmt_F updated to NF000113.1 16S_rRNA_Rmt_G-NCBI
           HMM Modified:  NF000114.1 16S_rRNA_Rmt_G updated to NF000114.1 16S_rRNA_Rmt_H-NCBI
           HMM Modified:  NF000115.2 AAC_6p_Iad updated to NF000115.2 AAC_6p_Iak-NCBI
           HMM Modified:  NF000116.1 16S_rRNA_Rmt_H updated to NF000116.1 16S_rRNA_Rmt_gen-NCBI
           HMM Modified:  NF000118.3 AAC_6p_A31 updated to NF000118.3 AAC_6p_A34-NCBI
           HMM Modified:  NF000119.1 linco_LnuF updated to NF000119.1 linco_LnuG-NCBI
           HMM Modified:  NF000120.3 47473_otr updated to NF000120.3 485965_fosC-NCBI
           HMM Modified:  NF000122.1 485965_fosC updated to NF000122.1 491618165_fosA-NCBI
           HMM Modified:  NF000123.2 AAC_6p_A34 updated to NF000123.2 AAC_6p_A37-NCBI
           HMM Modified:  NF000124.1 491618165_fosA updated to NF000124.1 498180014_fosA-NCBI
           HMM Modified:  NF000125.1 498180014_fosA updated to NF000125.1 AAC_2p_IIa-NCBI
           HMM Modified:  NF000126.2 trim_DfrA8 updated to NF000126.2 trim_DfrA9-NCBI
           HMM Modified:  NF000127.2 trim_DfrA20 updated to NF000127.2 trim_DfrA23-NCBI
           HMM Modified:  NF000128.1 vanH-Sc updated to NF000128.1 vanH_Agroup-NCBI
           HMM Modified:  NF000129.1 D_ala_D_lac_Sc updated to NF000129.1 D_ala_D_lac_VanA-NCBI
           HMM Modified:  NF000131.1 MATE_multi_MepA updated to NF000131.1 MATE_multi_NorM-NCBI
           HMM Modified:  NF000132.2 APH_2pp_Ig updated to NF000132.2 APH_3p-NCBI
           HMM Modified:  NF000133.1 Erm32 updated to NF000133.1 Erm37-NCBI
           HMM Modified:  NF000134.2 trim_DfrA23 updated to NF000134.2 trim_DfrA24-NCBI
           HMM Modified:  NF000135.2 AAC_6p_IIc updated to NF000135.2 AAC_6p_Ia_fam-NCBI
           HMM Modified:  NF000137.2 APH_7pp_Ia updated to NF000137.2 APH_9_Ia-NCBI
           HMM Modified:  NF000138.1 AAC_6p_Iz updated to NF000138.1 AAC_6p_Serra-NCBI
           HMM Modified:  NF000139.2 penta_rpt_QnrD updated to NF000139.2 penta_rpt_QnrE-NCBI
           HMM Modified:  NF000141.1 linco_LnuC updated to NF000141.1 linco_LnuD-NCBI
           HMM Modified:  NF000142.1 vanZ-Pt updated to NF000142.1 viomycin_Vph-NCBI
           HMM Modified:  NF000143.1 trim_DfrG updated to NF000143.1 trim_DfrI-NCBI
           HMM Modified:  NF000144.1 D_ala_D_lac_VanF updated to NF000144.1 D_ala_D_lac_VanI-NCBI
           HMM Modified:  NF000145.1 vanZ-F updated to NF000145.1 vanZ-Pt-NCBI
           HMM Modified:  NF000146.2 trim_DfrA24 updated to NF000146.2 trim_DfrA26-NCBI
           HMM Modified:  NF000147.1 stregram_VatF updated to NF000147.1 stregram_VatH-NCBI
           HMM Modified:  NF000148.1 SMR_qac_pB8 updated to NF000148.1 Shiga_Stx1A-NCBI
           HMM Modified:  NF000149.1 vanXY_G updated to NF000149.1 vanY_AFMPt-NCBI
           HMM Modified:  NF000150.1 16S_rRNA_Rmt_C updated to NF000150.1 16S_rRNA_Rmt_D-NCBI
           HMM Modified:  NF000151.1 vanH-Ac1 updated to NF000151.1 vanH-Amyco-NCBI
           HMM Modified:  NF000152.2 AAC_6p_A37 updated to NF000152.2 AAC_6p_A40-NCBI
           HMM Modified:  NF000153.1 linco_LnuAN2 updated to NF000153.1 linco_LnuB-NCBI
           HMM Modified:  NF000154.1 macrolide_MefEN2 updated to NF000154.1 macrolide_MphA-NCBI
           HMM Modified:  NF000155.1 trim_DfrC updated to NF000155.1 trim_DfrD-NCBI
           HMM Modified:  NF000157.1 fusid_est_FusH updated to NF000157.1 glycotrans_Rgt-NCBI
           HMM Modified:  NF000158.2 AAC_6p_Il updated to NF000158.2 AAC_6p_Im-NCBI
           HMM Modified:  NF000159.1 trim_DfrD updated to NF000159.1 trim_DfrDGK-NCBI
           HMM Modified:  NF000165.3 AAC_6p_Entco updated to NF000165.3 AAC_6p_IIc-NCBI
           HMM Modified:  NF000166.1 ABCF_CarA updated to NF000166.1 ABCF_Lsa_all-NCBI
           HMM Modified:  NF000167.1 ABCF_Lsa_all updated to NF000167.1 ABCF_Msr_all-NCBI
           HMM Modified:  NF000168.1 ABCF_Msr_all updated to NF000168.1 ABCF_OptrA-NCBI
           HMM Modified:  NF000169.1 ABCF_Sal updated to NF000169.1 ABCF_Vga_all-NCBI
           HMM Modified:  NF000170.1 ABCF_Vga_all updated to NF000170.1 ABCF_producer-NCBI
           HMM Modified:  NF000171.1 ABCF_producer updated to NF000171.1 ANT_2pp_Ia-NCBI
           HMM Modified:  NF000181.1 ANT_4p_Ia updated to NF000181.1 ANT_4p_Ib-NCBI
           HMM Modified:  NF000185.2 BlaEC updated to NF000185.2 BlaI_of_MRSA-NCBI
           HMM Modified:  NF000186.1 BlaI_of_MRSA updated to NF000186.1 BlaMIR-NCBI
           HMM Modified:  NF000187.3 BlaMIR updated to NF000187.3 BlmB-NCBI
           HMM Modified:  NF000188.2 CARB updated to NF000188.2 CAR_gen_B3-NCBI
           HMM Modified:  NF000191.1 CMY2 updated to NF000191.1 CfrAB-NCBI
           HMM Modified:  NF000206.1 D_ala_D_lac updated to NF000206.1 D_ala_D_lac_Ao2-NCBI
           HMM Modified:  NF000207.3 D_ala_D_ser updated to NF000207.3 D_ala_D_ser_VanC-NCBI
           HMM Modified:  NF000208.1 EreA updated to NF000208.1 EreB-NCBI
           HMM Modified:  NF000209.1 EreB updated to NF000209.1 EreD-NCBI
           HMM Modified:  NF000216.2 blaFEZ updated to NF000216.2 blaFIM-NCBI
           HMM Modified:  NF000218.1 FexA updated to NF000218.1 FloR-NCBI
           HMM Modified:  NF000219.1 FloR updated to NF000219.1 FosA-NCBI
           HMM Modified:  NF000221.4 FosA updated to NF000221.4 FosF-NCBI
           HMM Modified:  NF000222.1 FosX updated to NF000222.1 Fos_BSH-NCBI
           HMM Modified:  NF000224.3 AAC_6p_Acine updated to NF000224.3 AAC_6p_Entco-NCBI
           HMM Modified:  NF000225.3 AAC_6p_Strep updated to NF000225.3 AAC_6p_Yersi-NCBI
           HMM Modified:  NF000232.1 L2   updated to NF000232.1 LEN-NCBI
           HMM Modified:  NF000233.2 LEN  updated to NF000233.2 MATE_multi_MepA-NCBI
           HMM Modified:  NF000235.3 linco_LnuB updated to NF000235.3 linco_LnuC-NCBI
           HMM Modified:  NF000236.1 linco_LnuA updated to NF000236.1 linco_LnuAN2-NCBI
           HMM Modified:  NF000237.1 MECA_PBP2A updated to NF000237.1 MECA_pure-NCBI
           HMM Modified:  NF000239.3 MOX_CMY1_fam updated to NF000239.3 MPH_3-NCBI
           HMM Modified:  NF000240.1 macrolide_MphC updated to NF000240.1 macrolide_MphE-NCBI
           HMM Modified:  NF000241.1 MPH_3 updated to NF000241.1 MecI_of_mecA-NCBI
           HMM Modified:  NF000242.1 macrolide_MphB updated to NF000242.1 macrolide_MphC-NCBI
           HMM Modified:  NF000243.1 MecI_of_mecA updated to NF000243.1 MecI_of_mecC-NCBI
           HMM Modified:  NF000244.1 MecI_of_mecC updated to NF000244.1 MerA-TIGRFAMs
           HMM Modified:  NF000245.1 macrolide_MefA updated to NF000245.1 macrolide_MefB-NCBI
           HMM Modified:  NF000246.1 macrolide_MefC updated to NF000246.1 macrolide_MefEN2-NCBI
           HMM Modified:  NF000249.1 MexE updated to NF000249.1 MexX-Resfams
           HMM Modified:  NF000254.1 macrolide_MphA updated to NF000254.1 macrolide_MphB-NCBI
           HMM Modified:  NF000255.1 macrolide_MphF updated to NF000255.1 merT_RC607-NCBI
           HMM Modified:  NF000256.1 MsrSA updated to NF000256.1 MupA-NCBI
           HMM Modified:  NF000257.1 MupA updated to NF000257.1 MupB-NCBI
           HMM Modified:  NF000258.1 MupB updated to NF000258.1 NimABCDEF-NCBI
           HMM Modified:  NF000259.2 blaNDM updated to NF000259.2 blaOCH-NCBI
           HMM Modified:  NF000261.1 NimABCDEF updated to NF000261.1 NimIJ-NCBI
           HMM Modified:  NF000262.1 NimIJ updated to NF000262.1 NshR_TsnR-NCBI
           HMM Modified:  NF000263.1 MATE_multi_NorM updated to NF000263.1 MECA1_pure-NCBI
           HMM Modified:  NF000264.2 blaOCH updated to NF000264.2 blaOXA-10_like-NCBI
           HMM Modified:  NF000265.2 OKP  updated to NF000265.2 OqxA_adapt_sub-NCBI
           HMM Modified:  NF000266.2 blaOXA-23_like updated to NF000266.2 blaOXA-24_like-NCBI
           HMM Modified:  NF000267.2 blaOXA-2_like updated to NF000267.2 blaOXA-364_like-NCBI
           HMM Modified:  NF000268.2 blaOXA-51_like updated to NF000268.2 blaOXA-55_like-NCBI
           HMM Modified:  NF000269.2 blaOXA-213_like updated to NF000269.2 blaOXA-214_like-NCBI
           HMM Modified:  NF000270.1 bla_class_D_alt updated to NF000270.1 bla_class_D_main-NCBI
           HMM Modified:  NF000271.2 blaOXY updated to NF000271.2 blaP-NCBI
           HMM Modified:  NF000272.1 OqxA_adapt_sub updated to NF000272.1 PRK10026.1-PRKfam
           HMM Modified:  NF000275.2 blaPLA_ORN_TER updated to NF000275.2 blaPME-NCBI
           HMM Modified:  NF000276.2 SMR_qac_E updated to NF000276.2 SMR_qac_FL-NCBI
           HMM Modified:  NF000277.1 qac_SMR_G updated to NF000277.1 qac_SMR_H-NCBI
           HMM Modified:  NF000278.1 SMR_qac_G2 updated to NF000278.1 SMR_qac_K-NCBI
           HMM Modified:  NF000279.1 qac_SMR_H updated to NF000279.1 qac_SMR_J-NCBI
           HMM Modified:  NF000280.1 SMR_efflux_smr updated to NF000280.1 SMR_qac_E-NCBI
           HMM Modified:  NF000283.1 RPH_KJ151292.1 updated to NF000283.1 RTG-NCBI
           HMM Modified:  NF000284.1 RTG  updated to NF000284.1 SHV-NCBI
           HMM Modified:  NF000285.3 SHV  updated to NF000285.3 SHV_LEN_OKP-NCBI
           HMM Modified:  NF000287.1 SMB1_fam updated to NF000287.1 SMR_efflux_smr-NCBI
           HMM Modified:  NF000294.1 Sul1 updated to NF000294.1 Sul2-NCBI
           HMM Modified:  NF000295.1 Sul2 updated to NF000295.1 Sul3-NCBI
           HMM Modified:  NF000296.1 Sul3 updated to NF000296.1 Sul4-NCBI
           HMM Modified:  NF000298.2 blaTLA updated to NF000298.2 blaTMB-NCBI
           HMM Modified:  NF000311.1 Vat_ABCDEFH updated to NF000311.1 aadE-Cc-NCBI
           HMM Modified:  NF000312.1 ANT_6_aadK updated to NF000312.1 ANT_6_aadS-NCBI
           HMM Modified:  NF000318.1 rifampin_ARR_Ms updated to NF000318.1 rifampin_ARR_Sa-NCBI
           HMM Modified:  NF000320.2 betalact_A_Burk_PenA updated to NF000320.2 betalact_A_Burk_PenI-NCBI
           HMM Modified:  NF000321.2 betalact_A_Burk_PenI updated to NF000321.2 bla-A_Chryseo-NCBI
           HMM Modified:  NF000322.2 blaCcrA updated to NF000322.2 blaDHA-NCBI
           HMM Modified:  NF000323.2 blaFONA updated to NF000323.2 blaFOX-NCBI
           HMM Modified:  NF000324.2 blaLUT updated to NF000324.2 blaMCA-NCBI
           HMM Modified:  NF000326.1 blaR1_generic updated to NF000326.1 blaRCP-NCBI
           HMM Modified:  NF000327.2 blaSCO updated to NF000327.2 blaSED-NCBI
           HMM Modified:  NF000328.2 blaSED updated to NF000328.2 blaSFH-NCBI
           HMM Modified:  NF000329.2 bla_B2_CphA updated to NF000329.2 bla_Bc_2-NCBI
           HMM Modified:  NF000330.1 trim_DfrA1_like updated to NF000330.1 trim_DfrA1_rpt-NCBI
           HMM Modified:  NF000331.1 trim_DfrB updated to NF000331.1 trim_DfrC-NCBI
           HMM Modified:  NF000332.1 trim_DfrDGK updated to NF000332.1 trim_DfrE-NCBI
           HMM Modified:  NF000333.1 trim_DfrF updated to NF000333.1 trim_DfrG-NCBI
           HMM Modified:  NF000336.1 emrE updated to NF000336.1 erm_38_23S_MT-NCBI
           HMM Modified:  NF000337.1 erm_SHROVE updated to NF000337.1 fomA_AB016934.1.gene6-NCBI
           HMM Modified:  NF000338.1 fomA_AB016934.1.gene6 updated to NF000338.1 fos-Crono-NCBI
           HMM Modified:  NF000339.2 fos-Crono updated to NF000339.2 fosA7-NCBI
           HMM Modified:  NF000340.1 fusB updated to NF000340.1 fusC-NCBI
           HMM Modified:  NF000341.1 fusC updated to NF000341.1 fusD-NCBI
           HMM Modified:  NF000343.1 rif_mono_Iri updated to NF000343.1 rif_monoox-NCBI
           HMM Modified:  NF000354.1 glycotrans_Rgt updated to NF000354.1 intimin_all-NCBI
           HMM Modified:  NF000355.3 ribo_prot_ABC_F updated to NF000355.3 rif_mono_Iri-NCBI
           HMM Modified:  NF000358.1 sat2 updated to NF000358.1 sat3-NCBI
           HMM Modified:  NF000359.1 sat3 updated to NF000359.1 sat4-NCBI
           HMM Modified:  NF000360.1 sat4 updated to NF000360.1 self_FomB_kinase-NCBI
           HMM Modified:  NF000361.1 self_FomB_kinase updated to NF000361.1 self_GT_OleI-NCBI
           HMM Modified:  NF000362.1 self_GT_OleI updated to NF000362.1 self_KamB-NCBI
           HMM Modified:  NF000363.1 self_KamB updated to NF000363.1 sensor_BlaR1-NCBI
           HMM Modified:  NF000371.1 vanH_Agroup updated to NF000371.1 vanH_gen-NCBI
           HMM Modified:  NF000372.1 D_ala_D_lac_VanI updated to NF000372.1 D_ala_D_lac_VanM-NCBI
           HMM Modified:  NF000373.1 vanJ updated to NF000373.1 vanR-A-NCBI
           HMM Modified:  NF000374.1 D_ala_D_lac_VanO updated to NF000374.1 D_ala_D_ser-NCBI
           HMM Modified:  NF000380.1 vanXY updated to NF000380.1 vanXY_G-NCBI
           HMM Modified:  NF000383.2 blaLAP updated to NF000383.2 blaLHK-NCBI
           HMM Modified:  NF000384.1 QacCGHJ updated to NF000384.1 RND_adapt_MexA-NCBI
           HMM Modified:  NF000385.4 blaACT updated to NF000385.4 blaADC-NCBI
           HMM Modified:  NF000386.2 blaOXA-10_like updated to NF000386.2 blaOXA-114_like-NCBI
           HMM Modified:  NF000387.2 blaOXA-48_like updated to NF000387.2 blaOXA-493_like-NCBI
           HMM Modified:  NF000388.2 blaOXA-1_like updated to NF000388.2 blaOXA-211_like-NCBI
           HMM Modified:  NF000389.2 blaPER updated to NF000389.2 blaPLA_ORN_TER-NCBI
           HMM Modified:  NF000390.2 blaVEB updated to NF000390.2 blaVIM-NCBI
           HMM Modified:  NF000395.3 blaOXA-60_like updated to NF000395.3 blaOXA-61_like-NCBI
           HMM Modified:  NF000396.2 blaGIM updated to NF000396.2 blaGOB-NCBI
           HMM Modified:  NF000397.2 blaACC updated to NF000397.2 blaACI-NCBI
           HMM Modified:  NF000398.2 blaBEL updated to NF000398.2 blaBES-NCBI
           HMM Modified:  NF000399.2 blaFOX updated to NF000399.2 blaFRI-NCBI
           HMM Modified:  NF000400.2 blaIMI updated to NF000400.2 blaIMP-NCBI
           HMM Modified:  NF000401.1 vanR-A updated to NF000401.1 vanR-B-NCBI
           HMM Modified:  NF000402.1 vanR-B updated to NF000402.1 vanR-C-NCBI
           HMM Modified:  NF000403.1 vanR-C updated to NF000403.1 vanR-D-NCBI
           HMM Modified:  NF000404.1 vanR-D updated to NF000404.1 vanR-O-NCBI
           HMM Modified:  NF000405.1 HARLDQ_not_B3 updated to NF000405.1 HK_VanS_ACDEFG-NCBI
           HMM Modified:  NF000406.1 MECB_PBP updated to NF000406.1 MECC_PBP-NCBI
           HMM Modified:  NF000407.1 MECC_PBP updated to NF000407.1 MECD_PBP-NCBI
           HMM Modified:  NF000408.1 MECA2_pure updated to NF000408.1 MECA_PBP2A-NCBI
           HMM Modified:  NF000409.1 MECA_pure updated to NF000409.1 MECB_PBP-NCBI
           HMM Modified:  NF000410.1 MECA1_pure updated to NF000410.1 MECA2_pure-NCBI
           HMM Modified:  NF000411.1 Erm45 updated to NF000411.1 ErmO-NCBI
           HMM Modified:  NF000412.1 Erm43 updated to NF000412.1 Erm45-NCBI
           HMM Modified:  NF000413.2 blaBKC updated to NF000413.2 blaBKC_GPC-NCBI
           HMM Modified:  NF000414.2 blaPME updated to NF000414.2 blaPOM-NCBI
           HMM Modified:  NF000415.2 blaOXA-372_like updated to NF000415.2 blaOXA-46_like-NCBI
           HMM Modified:  NF000417.2 blaOXA-211_like updated to NF000417.2 blaOXA-213_like-NCBI
           HMM Modified:  NF000418.2 blaOXA-214_like updated to NF000418.2 blaOXA-229_like-NCBI
           HMM Modified:  NF000419.2 blaCMH updated to NF000419.2 blaCPS-NCBI
           HMM Modified:  NF000420.1 penta_rpt_QnrB updated to NF000420.1 penta_rpt_QnrC-NCBI
           HMM Modified:  NF000421.1 penta_rpt_QnrVC updated to NF000421.1 phenyl_MerG-NCBI
           HMM Modified:  NF000422.6 blaPDC updated to NF000422.6 blaPDC_var-NCBI
           HMM Modified:  NF000423.2 blaSRT updated to NF000423.2 blaTEM-NCBI
           HMM Modified:  NF000424.3 CfrAB updated to NF000424.3 D_ala_D_lac-NCBI
           HMM Modified:  NF000425.2 blaADC updated to NF000425.2 blaAFM-NCBI
           HMM Modified:  NF000426.2 blaSIM updated to NF000426.2 blaSME-NCBI
           HMM Modified:  NF000427.2 blaCAU updated to NF000427.2 blaCBP-NCBI
           HMM Modified:  NF000428.4 blaFRI updated to NF000428.4 blaFTU-NCBI
           HMM Modified:  NF000429.2 blaOXA-63_like updated to NF000429.2 blaOXA-727_like-NCBI
           HMM Modified:  NF000430.2 blaOXA-62_like updated to NF000430.2 blaOXA-63_like-NCBI
           HMM Modified:  NF000431.1 AAC_6p_Ian updated to NF000431.1 AAC_6p_Ib-NCBI
           HMM Modified:  NF000432.2 blaOXA-50_like updated to NF000432.2 blaOXA-51_like-NCBI
           HMM Modified:  NF000434.2 blaOXA-24_like updated to NF000434.2 blaOXA-266_fam-NCBI
           HMM Modified:  NF000435.2 blaOXA-61_like updated to NF000435.2 blaOXA-62_like-NCBI
           HMM Modified:  NF000436.2 blaOXA-134_like updated to NF000436.2 blaOXA-143_like-NCBI
           HMM Modified:  NF000437.2 blaFIM updated to NF000437.2 blaFONA-NCBI
           HMM Modified:  NF000438.2 blaPOM updated to NF000438.2 blaPST-NCBI
           HMM Modified:  NF000439.2 blaAIM updated to NF000439.2 blaALI-NCBI
           HMM Modified:  NF000440.2 blaTHIN updated to NF000440.2 blaTLA-NCBI
           HMM Modified:  NF000441.2 blaMUS updated to NF000441.2 blaNDM-NCBI
           HMM Modified:  NF000442.2 blaTUS updated to NF000442.2 blaVCC-NCBI
           HMM Modified:  NF000443.2 blaTMB updated to NF000443.2 blaTTU-NCBI
           HMM Modified:  NF000444.2 blaEBR updated to NF000444.2 blaESP-1_fam-NCBI
           HMM Modified:  NF000445.2 blaDIM updated to NF000445.2 blaDIM_SIM_IMP-NCBI
           HMM Modified:  NF000446.2 blaCIA updated to NF000446.2 blaCMA-NCBI
           HMM Modified:  NF000447.2 bla-A_Chryseo updated to NF000447.2 bla-B1-FLAV-NCBI
           HMM Modified:  NF000448.2 blaACI updated to NF000448.2 blaACT-NCBI
           HMM Modified:  NF000449.2 blaBIC updated to NF000449.2 blaBJP-NCBI
           HMM Modified:  NF000450.2 bla-B1-FLAV updated to NF000450.2 bla1-NCBI
           HMM Modified:  NF000451.2 blaBES updated to NF000451.2 blaBIC-NCBI
           HMM Modified:  NF000452.2 blaKLUC updated to NF000452.2 blaKPC-NCBI
           HMM Modified:  NF000453.2 blaPEDO-3_fam updated to NF000453.2 blaPER-NCBI
           HMM Modified:  NF000454.2 blaCPS updated to NF000454.2 blaCRH-NCBI
           HMM Modified:  NF000455.2 blaESP-1_fam updated to NF000455.2 blaFEZ-NCBI
           HMM Modified:  NF000456.2 blaMSI-1_fam updated to NF000456.2 blaMUS-NCBI
           HMM Modified:  NF000457.2 blaPEDO-1_fam updated to NF000457.2 blaPEDO-2_fam-NCBI
           HMM Modified:  NF000458.2 blaPEDO-2_fam updated to NF000458.2 blaPEDO-3_fam-NCBI
           HMM Modified:  NF000459.2 blaSPG-1_fam updated to NF000459.2 blaSPM-NCBI
           HMM Modified:  NF000460.1 fusD updated to NF000460.1 fusF-NCBI
           HMM Modified:  NF000461.2 blaOXA-184_like updated to NF000461.2 blaOXA-1_like-NCBI
           HMM Modified:  NF000462.2 blaOXA-493_like updated to NF000462.2 blaOXA-50_like-NCBI
           HMM Modified:  NF000463.2 blaOXA_Campylobacter updated to NF000463.2 blaOXY-NCBI
           HMM Modified:  NF000464.2 blaOXA-143_like updated to NF000464.2 blaOXA-184_like-NCBI
           HMM Modified:  NF000465.1 polymyxin_MCR1 updated to NF000465.1 polymyxin_MCR2-NCBI
           HMM Modified:  NF000466.2 16S_rRNA_Rmt_gen updated to NF000466.2 299782349_fosC-NCBI
           HMM Modified:  NF000467.1 FosG updated to NF000467.1 FosK-NCBI
           HMM Modified:  NF000468.1 Erm37 updated to NF000468.1 Erm42-NCBI
           HMM Modified:  NF000469.2 CAR_gen_B3 updated to NF000469.2 CHL_hydrolase-NCBI
           HMM Modified:  NF000470.1 D_ala_D_lac_VanM updated to NF000470.1 D_ala_D_lac_VanO-NCBI
           HMM Modified:  NF000471.1 vanY_of_D updated to NF000471.1 vanZ-A-NCBI
           HMM Modified:  NF000472.1 vanY_AFMPt updated to NF000472.1 vanY_BG-NCBI
           HMM Modified:  NF000473.1 vanY_BG updated to NF000473.1 vanY_far-NCBI
           HMM Modified:  NF000474.1 tet_ABC_46_A updated to NF000474.1 tet_ABC_46_B-NCBI
           HMM Modified:  NF000475.1 tet_ABC_46_B updated to NF000475.1 tet_ABC_AB_A-NCBI
           HMM Modified:  NF000476.1 myrA updated to NF000476.1 nosihep_NshR-NCBI
           HMM Modified:  NF000477.1 NshR_TsnR updated to NF000477.1 OKP-NCBI
           HMM Modified:  NF000478.2 linco_LnuE updated to NF000478.2 linco_LnuF-NCBI
           HMM Modified:  NF000479.1 zbmA updated to NF000479.1
           HMM Modified:  NF000480.2 PSE  updated to NF000480.2 P_eth_NH2_trans-NCBI
           HMM Modified:  NF000481.1 carbeni_gen updated to NF000481.1 chaper_CopP-NCBI
           HMM Modified:  NF000482.1 AAC_3_XI updated to NF000482.1 AAC_6p_A10-NCBI
           HMM Modified:  NF000483.1 BlmB updated to NF000483.1 CARB-NCBI
           HMM Modified:  NF000485.1 TlmB updated to NF000485.1 VanC1_ser_lig-NCBI
           HMM Modified:  NF000486.1 AAC_6p_Ip updated to NF000486.1 AAC_6p_Iz-NCBI
           HMM Modified:  NF000487.1 stat updated to NF000487.1 stregra_B_VgbA-NCBI
           HMM Modified:  NF000488.1 chrB updated to NF000488.1 classA_carba-NCBI
           HMM Modified:  NF000489.1 ble_Sh updated to NF000489.1 carbeni_gen-NCBI
           HMM Modified:  NF000490.1 chloram_CatB updated to NF000490.1 chrB-NCBI
           HMM Modified:  NF000491.1 chloram_CatA updated to NF000491.1 chloram_CatB-NCBI
           HMM Modified:  NF000492.1 vanH_gen updated to NF000492.1 vanJ-NCBI
           HMM Modified:  NF000493.1 Fos_BSH updated to NF000493.1 Fos_BSH_Bcer-NCBI
           HMM Modified:  NF000494.1 FosF updated to NF000494.1 FosG-NCBI
           HMM Modified:  NF000495.1 FosK updated to NF000495.1 FosL-NCBI
           HMM Modified:  NF000496.1 Fos_GSH updated to NF000496.1 HARLDQ_not_B3-NCBI
           HMM Modified:  NF000497.1 AAC_6p_Iak updated to NF000497.1 AAC_6p_Ian-NCBI
           HMM Modified:  NF000498.2 APH_2pp_If_Ih updated to NF000498.2 APH_2pp_Ig-NCBI
           HMM Modified:  NF000499.1 Erm23S_rRNA_broad updated to NF000499.1 Erm32-NCBI
           HMM Modified:  NF000500.2 blaOXA-58_like updated to NF000500.2 blaOXA-60_like-NCBI
           HMM Modified:  NF000501.2 blaOXA-229_like updated to NF000501.2 blaOXA-22_like-NCBI
           HMM Modified:  NF000502.2 blaOXA-85_like updated to NF000502.2 blaOXA_Campylobacter-NCBI
           HMM Modified:  NF000503.1 fusF updated to NF000503.1 fusid_est_FusH-NCBI
           HMM Modified:  NF000504.1 stregram_VatH updated to NF000504.1 stregram_VatI-NCBI
           HMM Modified:  NF000505.2 blaGIL updated to NF000505.2 blaGIM-NCBI
           HMM Modified:  NF000506.1 tet_ABC_AB_A updated to NF000506.1 tet_ABC_AB_B-NCBI
           HMM Modified:  NF000507.1 AAC_6p_Ie updated to NF000507.1 AAC_6p_Ie_fam-NCBI
           HMM Modified:  NF000508.1 APH_2pp_Ia updated to NF000508.1 APH_2pp_Ie_IVa-NCBI
           HMM Modified:  NF000509.1 efflux_CmlA updated to NF000509.1 efflux_Cmx-NCBI
           HMM Modified:  NF000510.1 efflux_Cmx updated to NF000510.1 efflux_OM_AdeC-NCBI
           HMM Modified:  NF000511.2 blaCME updated to NF000511.2 blaCMH-NCBI
           HMM Modified:  NF000512.2 blaSGM updated to NF000512.2 blaSIM-NCBI
           HMM Modified:  NF000513.2 blaFTU updated to NF000513.2 blaGES-NCBI
           HMM Modified:  NF000514.1 ABCF_OptrA updated to NF000514.1 ABCF_Sal-NCBI
           HMM Modified:  NF000516.1 EreD updated to NF000516.1 Erm23S_rRNA_broad-NCBI
           HMM Modified:  NF000517.2 blaCBP updated to NF000517.2 blaCDD-NCBI
           HMM Modified:  NF000518.2 blaVCC updated to NF000518.2 blaVEB-NCBI
           HMM Modified:  NF000519.2 blaPDC_var updated to NF000519.2 blaPEDO-1_fam-NCBI
           HMM Modified:  NF000520.2 blaOXA-286_like updated to NF000520.2 blaOXA-2_like-NCBI
           HMM Modified:  NF000531.2 blaTEM updated to NF000531.2 blaTHIN-NCBI
           HMM Modified:  NF000538.0 classA_carba updated to NF000538.0 classA_firm-NCBI
           HMM Modified:  NF007456.1 PRK10026.1 updated to NF007456.1 PRK13747.1-PRKfam
           HMM Modified:  NF010310.2 PRK13747.1 updated to NF010310.2 PRK13752.1-PRKfam
           HMM Modified:  NF010315.0 PRK13752.1 updated to NF010315.0 PSE-NCBI
           HMM Modified:  NF012098.1 blaBPU updated to NF012098.1 blaCAM-NCBI
           HMM Modified:  NF012099.1 SubclassA2 updated to NF012099.1 Sul1-NCBI
           HMM Modified:  NF012100.0 blaVIM updated to NF012100.0 blaZ-NCBI
           HMM Modified:  NF012101.1 blaGOB updated to NF012101.1 blaIMI-NCBI
           HMM Modified:  NF012102.1 blaDHA updated to NF012102.1 blaDIM-NCBI
           HMM Modified:  NF012103.0 blaGES updated to NF012103.0 blaGIL-NCBI
           HMM Modified:  NF012137.0 bla_xUS updated to NF012137.0 ble_BLMA_gen-NCBI
           HMM Modified:  NF012140.0 blaBJP updated to NF012140.0 blaBKC-NCBI
           HMM Modified:  NF012141.0 blaKPC updated to NF012141.0 blaL-NCBI
           HMM Modified:  NF012142.0 blaSME updated to NF012142.0 blaSPG-1_fam-NCBI
           HMM Modified:  NF012143.0 SHV_LEN_OKP updated to NF012143.0 SMB1_fam-NCBI
           HMM Modified:  NF012145.1 blaDIM_SIM_IMP updated to NF012145.1 blaEBR-NCBI
           HMM Modified:  NF012146.1 blaB-IND-MUS updated to NF012146.1 blaB-NCBI
           HMM Modified:  NF012147.1 blaIMP updated to NF012147.1 blaIND-NCBI
           HMM Modified:  NF012148.0 blaKHM-HMB updated to NF012148.0 blaKLUC-NCBI
           HMM Modified:  NF012149.0 blaIND updated to NF012149.0 blaKHM-HMB-NCBI
           HMM Modified:  NF012150.3 blaSPM updated to NF012150.3 blaSRT-NCBI
           HMM Modified:  NF012151.0 penta_rpt_QnrAS updated to NF012151.0 penta_rpt_QnrB-NCBI
           HMM Modified:  NF012152.0 penta_rpt_QnrC updated to NF012152.0 penta_rpt_QnrD-NCBI
           HMM Modified:  NF012153.1 tet_protect updated to NF012153.1 tet_protect_M-NCBI
           HMM Modified:  NF012154.0 tet_protect_Q updated to NF012154.0 tet_prtrans_34-NCBI
           HMM Modified:  NF012155.1 tet_protect_M updated to NF012155.1 tet_protect_M_W-NCBI
           HMM Modified:  NF012156.1 blaP updated to NF012156.1 blaPAC-NCBI
           HMM Modified:  NF012157.0 ANT_3pp_I updated to NF012157.0 ANT_3pp_II-NCBI
           HMM Modified:  NF012158.1 macrolide_MphE updated to NF012158.1 macrolide_MphF-NCBI
           HMM Modified:  NF012159.0 polymyxin_MCR2 updated to NF012159.0 polymyxin_MCR3-NCBI
           HMM Modified:  NF012160.0 APH_6_Steno updated to NF012160.0 APH_7pp_Ia-NCBI
           HMM Modified:  NF012161.0 bla_class_D_main updated to NF012161.0 bla_subclass_B1-NCBI
           HMM Modified:  NF012165.0 AAC_6p_set_A updated to NF012165.0 ABCF_CarA-NCBI
           HMM Modified:  NF012167.0 classA_firm updated to NF012167.0 cmlA_floR-NCBI
           HMM Modified:  NF012169.0 qepA updated to NF012169.0 rRNA_meth_EmtA-NCBI
           HMM Modified:  NF012170.0 qac_SMR_J updated to NF012170.0 qepA-NCBI
           HMM Modified:  NF012171.0 APH_6 updated to NF012171.0 APH_6_Ic-NCBI
           HMM Modified:  NF012172.1 FOX-MOX updated to NF012172.1 FexA-NCBI
           HMM Modified:  NF012173.1 CMY2-MIR-ACT-EC updated to NF012173.1 CMY2-NCBI
           HMM Modified:  NF012174.0 tet_MFS_A_B_C_D updated to NF012174.0 tet_MFS_B-NCBI
           HMM Modified:  NF012175.1 tet_MFS_L_K_45 updated to NF012175.1 tet_MFS_OtrB-NCBI
           HMM Modified:  NF012176.0 tet_MFS_38 updated to NF012176.0 tet_MFS_40-NCBI
           HMM Modified:  NF012177.1 tet_MFS_42 updated to NF012177.1 tet_MFS_43-NCBI
           HMM Modified:  NF012178.0 tet_MFS_V updated to NF012178.0 tet_MFS_Y-NCBI
           HMM Modified:  NF012180.1 tet_MFS_43 updated to NF012180.1 tet_MFS_45-NCBI
           HMM Modified:  NF012183.0 tet_MFS_K updated to NF012183.0 tet_MFS_L-NCBI
           HMM Modified:  NF012184.0 tet_MFS_45 updated to NF012184.0 tet_MFS_A-NCBI
           HMM Modified:  NF012185.0 tet_MFS_L updated to NF012185.0 tet_MFS_L_K_45-NCBI
           HMM Modified:  NF012186.0 tet_MFS_D updated to NF012186.0 tet_MFS_E-NCBI
           HMM Modified:  NF012187.0 tet_MFS_E updated to NF012187.0 tet_MFS_G-NCBI
           HMM Modified:  NF012188.1 tet_MFS_Y updated to NF012188.1 tet_NaH_anti_35-NCBI
           HMM Modified:  NF012190.1 tet_MFS_B updated to NF012190.1 tet_MFS_C-NCBI
           HMM Modified:  NF012191.0 tet_MFS_C updated to NF012191.0 tet_MFS_D-NCBI
           HMM Modified:  NF012192.0 tet_MFS_G updated to NF012192.0 tet_MFS_H-NCBI
           HMM Modified:  NF012193.0 tet_MFS_A updated to NF012193.0 tet_MFS_A_B_C_D-NCBI
           HMM Modified:  NF012194.0 tet_MFS_J updated to NF012194.0 tet_MFS_K-NCBI
           HMM Modified:  NF012195.0 tet_MFS_H updated to NF012195.0 tet_MFS_H_J-NCBI
           HMM Modified:  NF012199.0 cml_V_MFS updated to NF012199.0 cmx_cmrA-NCBI
           HMM Modified:  NF012202.0 ble_MBL updated to NF012202.0 ble_Sh-NCBI
           HMM Modified:  NF012203.0 cmlB1_MFS updated to NF012203.0 cml_V_MFS-NCBI
           HMM Modified:  NF012207.0 tet_MFS_H_J updated to NF012207.0 tet_MFS_J-NCBI
           HMM Modified:  NF012212.0 ANT_9 updated to NF012212.0 APH_2pp_IIIa-NCBI
           HMM Modified:  NF012213.0 VanC1_ser_lig updated to NF012213.0 VarG_fam_MBL-NCBI
           HMM Modified:  NF012214.1 D_ala_D_ser_VanC updated to NF012214.1 D_ala_D_ser_VanE-NCBI
           HMM Modified:  NF012215.1 D_ala_D_lac_VanD updated to NF012215.1 D_ala_D_lac_VanF-NCBI
           HMM Modified:  NF012216.1 D_ala_D_lac_VanB updated to NF012216.1 D_ala_D_lac_VanD-NCBI
           HMM Modified:  NF012217.1 D_ala_D_lac_VanA updated to NF012217.1 D_ala_D_lac_VanB-NCBI
           HMM Modified:  NF012218.0 erm_38_23S_MT updated to NF012218.0 erm_A_23S_MT-NCBI
           HMM Modified:  NF012219.1 erm_C_23S_MT updated to NF012219.1 erm_F_23S_MT-NCBI
           HMM Modified:  NF012220.1 erm_B_23S_MT updated to NF012220.1 erm_C_23S_MT-NCBI
           HMM Modified:  NF012222.1 erm_A_23S_MT updated to NF012222.1 erm_B_23S_MT-NCBI
           HMM Modified:  NF012223.0 erm_F_23S_MT updated to NF012223.0 erm_SHROVE-NCBI
           HMM Modified:  NF012224.1 blaSFH updated to NF012224.1 blaSFH_gen-NCBI
           HMM Modified:  NF012225.0 blaSFH_gen updated to NF012225.0 blaSGM-NCBI
           HMM Modified:  NF012229.1 bla_class_B_core updated to NF012229.1 bla_class_C-NCBI
           HMM Modified:  NF028535.0 ANT_4p_II updated to NF028535.0 ANT_4p_Ia-NCBI
           HMM Modified:  NF032892.0 fosA7 updated to NF032892.0 fosA8-NCBI
           HMM Modified:  NF032894.1 APH_3pp_Ia updated to NF032894.1 APH_3pp_Ib-NCBI
           HMM Modified:  NF032895.1 APH_3pp_Ib updated to NF032895.1 APH_4_Ia-NCBI
           HMM Modified:  NF032896.1 APH_3pp updated to NF032896.1 APH_3pp_Ia-NCBI
           HMM Modified:  NF032897.1 APH_3p_V updated to NF032897.1 APH_3p_VI-NCBI
           HMM Modified:  NF032898.1 APH_3p_II updated to NF032898.1 APH_3p_IIIa-NCBI
           HMM Modified:  NF033059.2 APH_3p_I updated to NF033059.2 APH_3p_II-NCBI
           HMM Modified:  NF033060.0 blaBCL updated to NF033060.0 blaBEL-NCBI
           HMM Modified:  NF033061.1 ANT_4p_I updated to NF033061.1 ANT_4p_II-NCBI
           HMM Modified:  NF033062.0 APH_3p_VI updated to NF033062.0 APH_3p_VIII-NCBI
           HMM Modified:  NF033063.0 APH_3p_XV updated to NF033063.0 APH_3pp-NCBI
           HMM Modified:  NF033064.0 APH_3p_IIIa updated to NF033064.0 APH_3p_IVa-NCBI
           HMM Modified:  NF033065.0 APH_3p_IVa updated to NF033065.0 APH_3p_V-NCBI
           HMM Modified:  NF033066.0 APH_3p_VIII updated to NF033066.0 APH_3p_VIIa-NCBI
           HMM Modified:  NF033067.1 APH_3p_VIIa updated to NF033067.1 APH_3p_XV-NCBI
           HMM Modified:  NF033068.1 APH_3p updated to NF033068.1 APH_3p_A16-NCBI
           HMM Modified:  NF033074.0 AAC_6p_Ib updated to NF033074.0 AAC_6p_Id-NCBI
           HMM Modified:  NF033075.0 AAC_6p_Steno updated to NF033075.0 AAC_6p_Strep-NCBI
           HMM Modified:  NF033076.0 AAC_6p_Yersi updated to NF033076.0 AAC_6p_set_A-NCBI
           HMM Modified:  NF033077.0 AAC_6p_A30 updated to NF033077.0 AAC_6p_A31-NCBI
           HMM Modified:  NF033078.2 AAC_6p_Ia_fam updated to NF033078.2 AAC_6p_Iad-NCBI
           HMM Modified:  NF033080.0 AAC_3_II updated to NF033080.0 AAC_3_IV-NCBI
           HMM Modified:  NF033081.0 AAC_3_IV updated to NF033081.0 AAC_3_VIII-NCBI
           HMM Modified:  NF033082.0 AAC_3 updated to NF033082.0 AAC_3_I-NCBI
           HMM Modified:  NF033083.0 AAC_3_I updated to NF033083.0 AAC_3_II-NCBI
           HMM Modified:  NF033084.2 ANT_6 updated to NF033084.2 ANT_6_aadK-NCBI
           HMM Modified:  NF033085.1 bla_class_C updated to NF033085.1 bla_class_D_alt-NCBI
           HMM Modified:  NF033087.1 bla_subclass_B2 updated to NF033087.1 bla_subclass_B3-NCBI
           HMM Modified:  NF033088.1 bla_subclass_B1 updated to NF033088.1 bla_subclass_B2-NCBI
           HMM Modified:  NF033089.1 blaCTX-M updated to NF033089.1 blaCcrA-NCBI
           HMM Modified:  NF033090.1 HK_VanS_B updated to NF033090.1 HK_VanS_O-NCBI
           HMM Modified:  NF033091.0 HK_VanS_ACDEFG updated to NF033091.0 HK_VanS_B-NCBI
           HMM Modified:  NF033094.0 HK_VanS_O updated to NF033094.0 L2-NCBI
           HMM Modified:  NF033095.1 bla_Bc_2 updated to NF033095.1 bla_CblA-NCBI
           HMM Modified:  NF033096.1 bla1 updated to NF033096.1 blaACC-NCBI
           HMM Modified:  NF033098.1 bla_CblA updated to NF033098.1 bla_CepA-NCBI
           HMM Modified:  NF033099.1 bla_Exo updated to NF033099.1 bla_class_A-NCBI
           HMM Modified:  NF033100.1 bla_CfxA updated to NF033100.1 bla_Exo-NCBI
           HMM Modified:  NF033101.0 blaL updated to NF033101.0 blaL1-NCBI
           HMM Modified:  NF033102.1 bla_CepA updated to NF033102.1 bla_CfxA-NCBI
           HMM Modified:  NF033103.1 bla_class_A updated to NF033103.1 bla_class_B_core-NCBI
           HMM Modified:  NF033104.0 blaOXA-46_like updated to NF033104.0 blaOXA-48_like-NCBI
           HMM Modified:  NF033105.1 bla_subclass_B3 updated to NF033105.1 bla_xUS-NCBI
           HMM Modified:  NF033106.1 blaL1 updated to NF033106.1 blaLAP-NCBI
           HMM Modified:  NF033107.1 blaB updated to NF033107.1 blaBBI-NCBI
           HMM Modified:  NF033108.1 sensor_BlaR1 updated to NF033108.1 sensor_MecR1-NCBI
           HMM Modified:  NF033109.1 sensor_MecR1 updated to NF033109.1 stat-NCBI
           HMM Modified:  NF033111.2 tet_monoox_X updated to NF033111.2 tet_protect-NCBI
           HMM Modified:  NF033112.0 APH_3p_A16 updated to NF033112.0 APH_3p_I-NCBI
           HMM Modified:  NF033114.1 phos_trans_CPT updated to NF033114.1 poly_MCR3_broad-NCBI
           HMM Modified:  NF033115.1 dipept_VanX updated to NF033115.1 efflux_CmlA-NCBI
           HMM Modified:  NF033117.2 vanR_ACDEGLN updated to NF033117.2 vanR_FM-NCBI
           HMM Modified:  NF033118.1 vanR-O updated to NF033118.1 vanR_ACDEGLN-NCBI
           HMM Modified:  NF033120.0 vanR_FM updated to NF033120.0 vanT-CELN-NCBI
           HMM Modified:  NF033122.1 vanW-B updated to NF033122.1 vanW-G-NCBI
           HMM Modified:  NF033123.1 vanW-G updated to NF033123.1 vanW-gen-NCBI
           HMM Modified:  NF033125.2 vanZ-A updated to NF033125.2 vanZ-F-NCBI
           HMM Modified:  NF033126.1 ANT_3pp_AadA1 updated to NF033126.1 ANT_3pp_AadA3-NCBI
           HMM Modified:  NF033127.1 ANT_3pp_AadA3 updated to NF033127.1 ANT_3pp_I-NCBI
           HMM Modified:  NF033128.2 vanW-gen updated to NF033128.2 vanXY-NCBI
           HMM Modified:  NF033129.1 macro_glyco_Mgt updated to NF033129.1 macrolide_MefA-NCBI
           HMM Modified:  NF033130.1 AAC_6p_A48 updated to NF033130.1 AAC_6p_A49-NCBI
           HMM Modified:  NF033131.1 vanT-G-Cterm updated to NF033131.1 vanT-L-cat-NCBI
           HMM Modified:  NF033132.1 vanT-CELN updated to NF033132.1 vanT-G-Cterm-NCBI
           HMM Modified:  NF033133.1 vanT-L-cat updated to NF033133.1 vanT-L-mem-NCBI
           HMM Modified:  NF033135.1 cmx_cmrA updated to NF033135.1 coreg_MerD-NCBI
           HMM Modified:  NF033136.1 SMR_qac_K updated to NF033136.1 SMR_qac_bcrB-NCBI
           HMM Modified:  NF033137.0 SMR_qac_int updated to NF033137.0 SMR_qac_pB8-NCBI
           HMM Modified:  NF033139.1 blaZ updated to NF033139.1 blaZ_gen-NCBI
           HMM Modified:  NF033140.0 blaZ_mecC_type updated to NF033140.0 bla_B2_CphA-NCBI
           HMM Modified:  NF033141.0 blaZ_gen updated to NF033141.0 blaZ_mecC_type-NCBI
           HMM Modified:  NF033142.1 efflux_OM_AdeC updated to NF033142.1 emrE-Resfams
           HMM Modified:  NF033144.1 rifampin_ARR updated to NF033144.1 rifampin_ARR_Ms-NCBI
           HMM Modified:  NF033145.1 rif_monoox updated to NF033145.1 rifampin_ARR-NCBI
           HMM Modified:  NF033148.1 tet_protect_M_W updated to NF033148.1 tet_protect_Q-NCBI
           HMM Modified:  NF033149.0 CHL_hydrolase updated to NF033149.0 CMY2-MIR-ACT-EC-NCBI
           HMM Modified:  NF033150.1 AAC_6p_A49 updated to NF033150.1 AAC_6p_Acine-NCBI
           HMM Modified:  NF033151.0 AAC_6p_A10 updated to NF033151.0 AAC_6p_A29-NCBI
           HMM Modified:  NF033152.0 BlaA_Yent updated to NF033152.0 BlaEC-NCBI
           HMM Modified:  NF033156.1 ble_BLMA_gen updated to NF033156.1 ble_BLMT-NCBI
           HMM Modified:  NF033159.0 blaPAC updated to NF033159.0 blaPAU-NCBI
           HMM Modified:  NF033174.0 blaPSV updated to NF033174.0 blaR1_generic-NCBI
           HMM Modified:  NF033180.1 AAC_3_VIII updated to NF033180.1 AAC_3_VIa-NCBI
           HMM Modified:  NF033182.0 linco_LnuG updated to NF033182.0 linco_LnuP-NCBI
           HMM Modified:  NF033204.1 blaRUB updated to NF033204.1 blaSCO-NCBI
           HMM Modified:  NF033209.1 16S_rRNA_Rmt_B updated to NF033209.1 16S_rRNA_Rmt_C-NCBI
           HMM Modified:  NF033211.1 blaCRH updated to NF033211.1 blaCSA-NCBI
           HMM Modified:  NF033220.1 ANT_3pp_II updated to NF033220.1 ANT_4p_I-NCBI
           HMM Modified:  NF033221.1 aadE-Cc updated to NF033221.1 acid_shock_Asr-NCBI
           HMM Modified:  NF033374.6 AAC_6p_Id updated to NF033374.6 AAC_6p_Ie-NCBI
           HMM Modified:  NF033375.2 penta_rpt_QnrE updated to NF033375.2 penta_rpt_QnrS-NCBI
           HMM Modified:  NF033378.1 MECD_PBP updated to NF033378.1 MFS_efflux_PexA-NCBI
           HMM Modified:  NF033386.1 blaARL updated to NF033386.1 blaAXC-NCBI
           HMM Modified:  NF033387.1 ANT_6_aadS updated to NF033387.1 ANT_6_str-NCBI
           HMM Modified:  NF033398.1 rRNA_meth_EmtA updated to NF033398.1 ribo_prot_ABC_F-NCBI
           HMM Modified:  NF033405.1 FosL updated to NF033405.1 FosX-NCBI
           HMM Modified:  NF033406.1 blaMCA updated to NF033406.1 blaMSI-1_fam-NCBI
           HMM Modified:  NF033408.5 polymyxin_MCR3 updated to NF033408.5 polymyxin_MCR4-NCBI
           HMM Modified:  NF033409.0 poly_MCR3_broad updated to NF033409.0 polymyxin_MCR1-NCBI
           HMM Modified:  NF033462.1 polymyxin_MCR4 updated to NF033462.1 polymyxin_MCR5-NCBI
           HMM Modified:  NF033463.1 polymyxin_MCR5 updated to NF033463.1 polymyxin_MCR6-NCBI
           HMM Modified:  NF033466.0 blaRCP updated to NF033466.0 blaRHO-NCBI
           HMM Modified:  NF033467.0 blaAQU updated to NF033467.0 blaARL-NCBI
           HMM Modified:  NF033468.1 stregram_VatI updated to NF033468.1 tet_ABC_46_A-NCBI
           HMM Modified:  NF033469.1 SMR_qac_bcrB updated to NF033469.1 SMR_qac_bcrC-NCBI
           HMM Modified:  NF033470.1 SMR_qac_bcrC updated to NF033470.1 SMR_qac_int-NCBI
           HMM Modified:  NF033472.1 AAC_2p_IIb updated to NF033472.1 AAC_2p_Ia-NCBI
           HMM Modified:  NF033473.1 trim_DfrE updated to NF033473.1 trim_DfrF-NCBI
           HMM Modified:  NF033476.1 tet_destruct updated to NF033476.1 tet_monoox_X-NCBI
           HMM Modified:  NF033502.0 Sul4 updated to NF033502.0 TlmB-NCBI
           HMM Modified:  NF033509.1 blaOXA-22_like updated to NF033509.1 blaOXA-23_like-NCBI
           HMM Modified:  NF033555.1 lyase_MerB updated to NF033555.1 macro_glyco_Mgt-NCBI
           HMM Modified:  NF033560.1 merT_RC607 updated to NF033560.1 myrA-NCBI
           HMM Modified:  NF033565.0 trans_MerF updated to NF033565.0 trans_reg_VanU-NCBI
           HMM Modified:  NF033568.1 blaROB updated to NF033568.1 blaRUB-NCBI
           HMM Modified:  NF033569.1 blaLHK updated to NF033569.1 blaLUT-NCBI
           HMM Modified:  NF033574.1 VarG_fam_MBL updated to NF033574.1 Vat_ABCDEFH-NCBI
           HMM Modified:  NF033575.1 blaRHO updated to NF033575.1 blaROB-NCBI
           HMM Modified:  NF033582.2 blaALI updated to NF033582.2 blaAQU-NCBI
           HMM Modified:  NF033584.1 blaPST updated to NF033584.1 blaPSV-NCBI
           HMM Modified:  NF033585.1 blaTTU updated to NF033585.1 blaTUS-NCBI
           HMM Modified:  NF033612.0 AAC_3_VIa updated to NF033612.0 AAC_3_XI-NCBI
           HMM Modified:  NF033613.1 blaOXA-576_like updated to NF033613.1 blaOXA-58_like-NCBI
           HMM Modified:  NF033614.1 APH_6_Ic_gen updated to NF033614.1 APH_6_Steno-NCBI
           HMM Modified:  NF033626.1 blaBKC_GPC updated to NF033626.1 blaBPU-NCBI
           HMM Modified:  NF033627.3 intimin_all updated to NF033627.3 intimin_alpha-NCBI
           HMM Modified:  NF033636.1 acid_shock_Asr updated to NF033636.1 adeC-adeK-oprM-Resfams
           HMM Modified:  NF033637.1 transloc_TIR updated to NF033637.1 transport_merC-NCBI
           HMM Modified:  NF033639.1 intimin_alpha updated to NF033639.1 linco_LnuA-NCBI
           HMM Modified:  NF033646.1 toxin_EAST1 updated to NF033646.1 trans_MerF-NCBI
           HMM Modified:  NF033648.1 blaOXA-274_like updated to NF033648.1 blaOXA-286_like-NCBI
           HMM Modified:  NF033658.1 Shiga_Stx1A updated to NF033658.1 Shiga_Stx1B-NCBI
           HMM Modified:  NF033659.0 Shiga_Stx1B updated to NF033659.0 Shiga_Stx2A-NCBI
           HMM Modified:  NF033660.0 Shiga_Stx2B updated to NF033660.0 SubclassA2-NCBI
           HMM Modified:  NF033661.1 Shiga_Stx2A updated to NF033661.1 Shiga_Stx2B-NCBI
           HMM Modified:  NF033666.1 blaOXA-727_like updated to NF033666.1 blaOXA-85_like-NCBI
           HMM Modified:  NF033667.1 blaOXA-55_like updated to NF033667.1 blaOXA-576_like-NCBI
           HMM Modified:  NF033669.1 polymyxin_MCR8 updated to NF033669.1 polymyxin_MCR9-NCBI
           HMM Modified:  NF033670.1 polymyxin_MCR6 updated to NF033670.1 polymyxin_MCR7-NCBI
           HMM Modified:  NF033671.1 polymyxin_MCR7 updated to NF033671.1 polymyxin_MCR8-NCBI
           HMM Modified:  NF033692.1 APH_2pp_I_a_f_h updated to NF033692.1 APH_2pp_Ia-NCBI
           HMM Modified:  NF033693.0 AAC_6p_Ie_fam updated to NF033693.0 AAC_6p_If-NCBI
           HMM Modified:  NF033698.1 blaCSA updated to NF033698.1 blaCTX-M-NCBI
           HMM Modified:  NF033700.1 blaCMA updated to NF033700.1 blaCME-NCBI
           HMM Modified:  NF033702.0 blaOXA-12_like updated to NF033702.0 blaOXA-134_like-NCBI
           HMM Modified:  NF033714.1 blaBBI updated to NF033714.1 blaBCL-NCBI
           HMM Modified:  NF033727.1 chaperon_ArsD updated to NF033727.1 chloram_CatA-NCBI
           HMM Modified:  NF033736.1 blaAFM updated to NF033736.1 blaAIM-NCBI
           HMM Modified:  NF033781.1 chaper_CopP updated to NF033781.1 chaperon_ArsD-NCBI
           HMM Modified:  NF033783.1 coreg_MerD updated to NF033783.1 cyto_nec_fctrs-NCBI
           HMM Modified:  NF033784.1 transport_merC updated to NF033784.1 trim_DfrA10-NCBI
           HMM Modified:  NF033786.1 phenyl_MerG updated to NF033786.1 phos_trans_CPT-NCBI
           HMM Modified:  NF033815.0 blaOXA-364_like updated to NF033815.0 blaOXA-372_like-NCBI
           HMM Modified:  NF033818.0 blaOXA-114_like updated to NF033818.0 blaOXA-12_like-NCBI
           HMM Modified:  NF033834.1 RND_adapt_MexA updated to NF033834.1 RND_perm_OqxB-NCBI
           HMM Modified:  NF033836.1 polymyxin_MCR9 updated to NF033836.1 qac_MFS_AB-NCBI
           HMM Modified:  NF033851.1 trim_DfrA35 updated to NF033851.1 trim_DfrA36-NCBI
           HMM Modified:  NF033866.1 blaCDD updated to NF033866.1 blaCIA-NCBI
           HMM Modified:  NF033867.1 blaPAU updated to NF033867.1 blaPDC-NCBI
           HMM Modified:  NF033868.0 trim_DfrA36 updated to NF033868.0 trim_DfrA3b-NCBI
           HMM Modified:  NF033877.0 arsB_Sta_pI258 updated to NF033877.0 betalact_A_Burk_PenA-NCBI
           HMM Modified:  NF033895.1 blaCAM updated to NF033895.1 blaCAU-NCBI
           HMM Modified:  NF033929.1 blaAXC updated to NF033929.1 blaB-IND-MUS-NCBI
           HMM Modified:  NF033933.0 fosA8 updated to NF033933.0 fusB-NCBI
           HMM Modified:  TIGR02052.1 TIGR02052 updated to TIGR02052.1 MexE-Resfams
           HMM Modified:  TIGR02053.1 TIGR02053 updated to TIGR02053.1 MerP-TIGRFAMs
- Protein family changes:
                  Total:  Added           28
                  Total:  Prev. Release   1499
                  Total:  Removed         0
                  Total:  This Release    1527
           Family Added:  hmm_id          #fam_id
           Family Added:  -               afaC
           Family Added:  -               bin_CdtA
           Family Added:  -               bin_CdtB
           Family Added:  -               bmaE
           Family Added:  -               cvaC
           Family Added:  -               emrD
           Family Added:  -               focG
           Family Added:  -               ibeA
           Family Added:  -               iutA
           Family Added:  -               mcr-10
           Family Added:  -               papA
           Family Added:  -               papC
           Family Added:  -               papE
           Family Added:  -               papG
           Family Added:  -               papG-I
           Family Added:  -               papG-II
           Family Added:  -               papG-III
           Family Added:  -               papH
           Family Added:  -               sfaF
           Family Added:  -               tcdA
           Family Added:  -               tcdB
           Family Added:  -               tcdC
           Family Added:  -               tcdE
           Family Added:  -               tcdR
           Family Added:  -               tcd_gen
           Family Added:  -               tva(A)
           Family Added:  -               tva(B)
         Family Changed:  - blaOXA-266_fam updated to NF033653.1 blaOXA-266_fam

---------------------------------------------------------------------
Changes included in 2019-09-06.1
---------------------------------------------------------------------

This release just removes two accidentally included "plus" proteins.  We
suggest you switch to AMRFinderPlus. See https://github.com/ncbi/amr/wiki for
information an how to install since we will be dropping support for this
version of AMRFinder soon.

- Protein changes:
                  Total:  Added           0
                  Total:  Prev. Release   5984
                  Total:  Removed         2
                  Total:  This Release    5982
        Protein Removed:  AAB91079.1      bind_CopB       copper-binding_protein_CopB
        Protein Removed:  BAB62907.1      cofA            type_IV_pilus_CFA/III_major_pilin

---------------------------------------------------------------------
Changes included in 2019-09-6.1
---------------------------------------------------------------------

This release removes three erroniously included proteins that were provided by
collaborators, but accidentally released before review by curators.  these
sequences do not match the family, gene symbol, or protein name of the
virulence and stress response families to which they had been added. There are
no other changes.

We will add controls to the database publication system to programmatically
require that curators have manually reviewed all protein sequences before they
become public.

- Reference Gene Catalog protein and allele changes:
          Total in prev:  6274
       Total in release:  6271
                Removed:  3
                  Added:  0
                Changed:  0
                 Removed  copB AAB91079.1
                 Removed  aaiC AHW84565.1
                 Removed  cofA BAB62907.1

---------------------------------------------------------------------
Changes included in 2019-08-27.1
---------------------------------------------------------------------

This release includes a new database file to correspond with AMRFinderPlus
version 3.1 that includes information for blacklisting of a few "plus" proteins
common in some organisms that are interesting when found in others.  This
release also includes the usual new AMR genes and alleles; the fixing of some
typos; removal of a redundant point mutation reference sequence; and the
addition, reoorganization, and renaming of some "plus" genes.

- Reference Gene Catalog protein and allele changes:

          Total in prev:  6110
       Total in release:  6274
                Removed:  18
                  Added:  182
                Changed:  33
                 Removed  emrD3 WP_000850833.1
                 Removed  blaOXA-671 WP_016660101.1
                 Removed  arsB-mob WP_063116263.1
                 Removed  gyrA_A67S WP_001281242.1
                 Removed  gyrA_A84P WP_001281242.1
                 Removed  gyrA_D87G WP_001281242.1
                 Removed  gyrA_D87H WP_001281242.1
                 Removed  gyrA_D87N WP_001281242.1
                 Removed  gyrA_D87V WP_001281242.1
                 Removed  gyrA_D87Y WP_001281242.1
                 Removed  gyrA_G81C WP_001281242.1
                 Removed  gyrA_H80P WP_001281242.1
                 Removed  gyrA_N57K WP_001281242.1
                 Removed  gyrA_Q106H WP_001281242.1
                 Removed  gyrA_S83F WP_001281242.1
                 Removed  gyrA_S83I WP_001281242.1
                 Removed  gyrA_S83L WP_001281242.1
                 Removed  gyrA_S83W WP_001281242.1
                   Added  arsB AAA21095.1
                   Added  arsC AAA21096.1
                   Added  arsR AAA25636.1
                   Added  arsB AAA25637.1
                   Added  copC AAA25808.1
                   Added  arsR AAA27587.1
                   Added  arsB AAA27588.1
                   Added  arsR AAB09624.1
                   Added  arsC AAB09628.1
                   Added  arsC AAB42203.1
                   Added  arsB AAB42204.1
                   Added  ipaH9.8 AAC23714.1
                   Added  pic AAD23953.1
                   Added  efa1 AAD49229.2
                   Added  iha AAG55323.1
                   Added  stb AAK29747.1
                   Added  efa1 AAL57562.1
                   Added  pic AAN78833.1
                   Added  iha AAN82058.1
                   Added  cif AAQ07241.1
                   Added  iha AAT68782.1
                   Added  efa1 AAV91321.1
                   Added  sab AAZ76500.1
                   Added  senB AAZ89288.1
                   Added  iha ABB17254.1
                   Added  emrD3 ABQ18953.1
                   Added  kdeA ABR76310.1
                   Added  lmrC ABX00624.1
                   Added  iha ACB20136.1
                   Added  iha ACD08748.1
                   Added  amvA ACQ82816.1
                   Added  ipaH4 ADA74402.1
                   Added  iha ADI47068.1
                   Added  iha ADN47767.1
                   Added  arsR ADZ44504.1
                   Added  iha AEQ14190.1
                   Added  stb AET14866.1
                   Added  arsR AET17094.1
                   Added  pic AFS72825.1
                   Added  iha AFS75030.1
                   Added  asr BAA15331.2
                   Added  arsB BAA24823.1
                   Added  arsC BAA24824.1
                   Added  espK BAB34991.1
                   Added  fieF BAB89353.1
                   Added  fieF BAE77395.1
                   Added  arsR BAE77793.1
                   Added  cif BAG66370.1
                   Added  iha BAI27255.1
                   Added  efa1 BAI32294.1
                   Added  iha CAC39288.1
                   Added  efa1 CAC81883.1
                   Added  efa1 CAD30848.1
                   Added  stb CAD87835.1
                   Added  iha CAE55782.1
                   Added  efa1 CAI43818.1
                   Added  hlyA-alpha CAQ77251.1
                   Added  iha CAR09712.2
                   Added  pic CAU99295.1
                   Added  iha CBW53086.1
                   Added  ipaH5 EID63069.1
                   Added  fosB WP_000920239.1
                   Added  dfrA36 WP_000949574.1
                   Added  mphM WP_001041372.1
                   Added  cfr(B) WP_002405682.1
                   Added  mphK WP_003246254.1
                   Added  blaPDC-374 WP_003454242.1
                   Added  tet(56) WP_003635403.1
                   Added  blaCDD-1 WP_009901927.1
                   Added  mphH WP_015776248.1
                   Added  erm(49) WP_019728092.1
                   Added  blaCDD-2 WP_021361759.1
                   Added  mphN WP_024127776.1
                   Added  tet(X) WP_024160783.1
                   Added  blaPDC-361 WP_031638595.1
                   Added  tet(G) WP_032489471.1
                   Added  vga(E) WP_032495718.1
                   Added  blaACT-72 WP_045895620.1
                   Added  blaACT-70 WP_047364854.1
                   Added  blaACT-69 WP_048209719.1
                   Added  ble WP_063842967.1
                   Added  blaOXA-671 WP_081401608.1
                   Added  icr-Mo WP_082741435.1
                   Added  blaOXA-653 WP_087554513.1
                   Added  tet(X) WP_094309310.1
                   Added  blaMOX-13 WP_096807444.1
                   Added  blaFOX-15 WP_096807445.1
                   Added  blaCMY-157 WP_096807446.1
                   Added  blaIMP-69 WP_099156051.1
                   Added  blaPDC-249 WP_104009845.1
                   Added  blaACT-58 WP_111965422.1
                   Added  blaACT-62 WP_111967096.1
                   Added  blaACT-63 WP_112780466.1
                   Added  blaOXA-727 WP_114272532.1
                   Added  blaOXA-731 WP_116786833.1
                   Added  blaOXA-728 WP_116786835.1
                   Added  blaPDC-367 WP_121286063.1
                   Added  blaPDC-364 WP_121347819.1
                   Added  blaFLC-1 WP_123061077.1
                   Added  blaPDC-371 WP_126118969.1
                   Added  blaPDC-353 WP_128550481.1
                   Added  blaVIM-67 WP_142875125.1
                   Added  blaADC-196 WP_145850033.1
                   Added  blaAQU WP_148044401.1
                   Added  blaAQU WP_148044402.1
                   Added  dfrA29 WP_148044403.1
                   Added  blaCAM-1 WP_148044405.1
                   Added  blaCMY-165 WP_148044406.1
                   Added  blaCMY-166 WP_148044407.1
                   Added  blaCMY-167 WP_148044408.1
                   Added  blaCTX-M-227 WP_148044409.1
                   Added  blaCTX-M-228 WP_148044410.1
                   Added  blaCTX-M-229 WP_148044411.1
                   Added  blaDHA-29 WP_148044412.1
                   Added  blaGES-42 WP_148044413.1
                   Added  blaGES-43 WP_148044414.1
                   Added  blaIMP-82 WP_148044416.1
                   Added  blaIMP-83 WP_148044417.1
                   Added  blaIMP-84 WP_148044418.1
                   Added  blaKPC-41 WP_148044419.1
                   Added  blaKPC-45 WP_148044420.1
                   Added  blaKPC-46 WP_148044421.1
                   Added  blaOXA-835 WP_148044422.1
                   Added  blaOXA-836 WP_148044423.1
                   Added  blaPAU-1 WP_148044424.1
                   Added  blaPDC-196 WP_148044425.1
                   Added  blaPDC-334 WP_148044426.1
                   Added  blaPDC-335 WP_148044427.1
                   Added  blaPDC-336 WP_148044428.1
                   Added  blaPDC-337 WP_148044429.1
                   Added  blaPDC-338 WP_148044430.1
                   Added  blaPDC-339 WP_148044431.1
                   Added  blaPDC-340 WP_148044432.1
                   Added  blaPDC-341 WP_148044433.1
                   Added  blaPDC-342 WP_148044434.1
                   Added  blaPDC-343 WP_148044435.1
                   Added  blaPDC-344 WP_148044436.1
                   Added  blaPDC-345 WP_148044437.1
                   Added  blaPDC-346 WP_148044438.1
                   Added  blaPDC-347 WP_148044439.1
                   Added  blaPDC-348 WP_148044440.1
                   Added  blaPDC-349 WP_148044441.1
                   Added  blaPDC-350 WP_148044442.1
                   Added  blaPDC-351 WP_148044443.1
                   Added  blaPDC-352 WP_148044444.1
                   Added  blaPDC-354 WP_148044445.1
                   Added  blaPDC-355 WP_148044446.1
                   Added  blaPDC-356 WP_148044447.1
                   Added  blaPDC-357 WP_148044448.1
                   Added  blaPDC-358 WP_148044449.1
                   Added  blaPDC-359 WP_148044450.1
                   Added  blaPDC-360 WP_148044451.1
                   Added  blaPDC-362 WP_148044452.1
                   Added  blaPDC-363 WP_148044453.1
                   Added  blaPDC-365 WP_148044454.1
                   Added  blaPDC-366 WP_148044455.1
                   Added  blaPDC-368 WP_148044456.1
                   Added  blaPDC-369 WP_148044457.1
                   Added  blaPDC-370 WP_148044458.1
                   Added  blaPDC-372 WP_148044459.1
                   Added  blaPDC-373 WP_148044460.1
                   Added  blaPDC-375 WP_148044461.1
                   Added  blaPDC-376 WP_148044462.1
                   Added  blaPDC-377 WP_148044463.1
                   Added  blaPDC-378 WP_148044464.1
                   Added  blaPDC-379 WP_148044465.1
                   Added  blaPDC-380 WP_148044466.1
                   Added  blaPDC-381 WP_148044467.1
                   Added  blaPDC-382 WP_148044468.1
                   Added  blaPDC-383 WP_148044469.1
                   Added  blaPFM-1 WP_148044470.1
                   Added  blaTEM-241 WP_148044472.1
                   Added  blaTEM-242 WP_148044473.1
                   Added  blaTEM-39 WP_148044474.1
                   Added  blaVEB-22 WP_148044475.1
                   Added  blaVIM-68 WP_148044476.1
                   Added  mcr-1.22 WP_148044477.1
                   Added  mcr-5.4 WP_148044478.1
                   Added  blaOXA-837 WP_148281568.1
                   Added  gyrA_H80P WP_001281243.1
                   Added  gyrA_N57K WP_001281243.1
                   Added  gyrA_S83F WP_001281243.1
  Changes:
     faeG AAA24032.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG AAA24035.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG AAA24390.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     nccX AAA65102.1
                subclass                       METAL ->
     merB AAA88369.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merC AAC33908.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     faeG AAC34727.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     merB AAC38230.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merC AAC38233.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     ipaH2 AAN43435.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     mreA AAN68577.1
                subclass                       METAL ->
     ipaH2 AAZ87985.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     ipaH3 ABB62096.1
                gene_family                    ipaH9.8 -> ipaH3
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH3
     ipaH2 ABB62098.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     ipaH2 ABB66229.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     ipaH1 ABF02983.1
                gene_family                    ipaH9.8 -> ipaH1
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH1/H6
     ipaH2 ABF04028.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     faeG ACB72721.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     ipaH2 ACD09076.1
                gene_family                    ipaH9.8 -> ipaH2
                product_name                   T3SS effector E3 ubiquitin-protein ligase IpaH9.8 -> T3SS effector E3 ubiquitin-protein ligase IpaH2
     faeG AFH14350.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     merC BAA14138.2
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merB BAA20338.2
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merG BAA23166.1
                class                          MECURY -> MERCURY
     merB BAB47641.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     merB CAC86907.1
                class                          MECURY -> MERCURY
                subclass                       ORGANOMECURY -> ORGANOMERCURY
     faeG CAE82650.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG CAE82653.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     faeG CAE82670.1
                product_name                   F4 fimbrial adhesin subunit FaeG -> F4 (K88) fimbrial adhesin subunit FaeG
     mphL WP_002047670.1
                gene_family                    mph(B) -> mphL
                product_name                   Mph(B) family macrolide 2'-phosphotransferase -> macrolide 2'-phosphotransferase MphL
     poxtA WP_002415638.1
                genbank_cds_start              1856 -> 57639
                genbank_cds_stop               3484 -> 59267
                genbank_nucleotide_accession   MF095097.1 -> MH746818.1
     mcr-3.22 WP_094308975.1
                refseq_nucleotide_accession    NG_060581.1 -> NG_060581.2
     blaPDC-259 WP_109791193.1
                genbank_nucleotide_accession   MH243333.1 -> MH243333.2
                refseq_nucleotide_accession    NG_057591.1 -> NG_057591.2
     blaPDC-265 WP_109791199.1
                genbank_nucleotide_accession   MH243339.1 -> MH243339.2
                refseq_nucleotide_accession    NG_057597.1 -> NG_057597.2

- HMM library Changes:
                  Total:  Added           6
                  Total:  Prev. Release   603
                  Total:  Removed         1
                  Total:  This Release    608
            HMM Removed:  NF000274.2      PF04439
              HMM Added:  NF007456.1      PRK10026.1
              HMM Added:  NF033636.1      acid_shock_Asr
              HMM Added:  NF033877.0      arsB_Sta_pI258
              HMM Added:  NF033895.1      blaCAM
              HMM Added:  NF033929.1      blaAXC
              HMM Added:  NF033933.0      fosA8

- Protein family changes:
                  Total:  Added           47
                  Total:  Prev. Release   1454
                  Total:  Removed         1
                  Total:  This Release    1500
         Family Removed:  -               ubiq_IpaH3
           Family Added:  -               ACID
           Family Added:  -               CDF_efflux
           Family Added:  -               amvA
           Family Added:  NF033877.0      arsB_pI258
           Family Added:  -               arsB_pKW301
           Family Added:  -               arsB_pYV
           Family Added:  NF007456.1      arsC_gluta
           Family Added:  -               arsR
           Family Added:  -               arsR_K-12
           Family Added:  -               arsR_R46
           Family Added:  -               arsR_pI258
           Family Added:  -               arsR_pKW301
           Family Added:  -               arsR_pSX267
           Family Added:  -               arsR_pYV
           Family Added:  NF033636.1      asr
           Family Added:  NF033929.1      blaAXC
           Family Added:  NF033895.1      blaCAM
           Family Added:  -               blaPFM
           Family Added:  -               cif
           Family Added:  -               copC_Psyr
           Family Added:  -               dfrA29
           Family Added:  -               efa1
           Family Added:  -               erm(49)
           Family Added:  -               espK
           Family Added:  -               fieF
           Family Added:  NF033933.0      fosA8
           Family Added:  -               hlyA-alpha
           Family Added:  -               icr-Mo
           Family Added:  -               iha
           Family Added:  -               ipaH1
           Family Added:  -               ipaH2
           Family Added:  -               ipaH3
           Family Added:  -               ipaH4
           Family Added:  -               ipaH5
           Family Added:  -               ipa_gen
           Family Added:  -               kdeA
           Family Added:  -               lmrC_abcf
           Family Added:  -               mphH
           Family Added:  -               mphK
           Family Added:  -               mphL
           Family Added:  -               mphM
           Family Added:  -               mphN
           Family Added:  -               pic_auto
           Family Added:  -               sab
           Family Added:  -               senB
           Family Added:  -               stb
           Family Added:  -               tet(56)
         Family Changed:  NF000274.2 ant6_gen updated to - ant6_gen

---------------------------------------------------------------------
Changes included in 2019-07-10.1
---------------------------------------------------------------------

New alleles and sequences were added, a few product names were made more
specific as more phenotype information became available. Cleanup of the
database caused some families and HMMs not used by AMRFinderPlus to be removed.

- Protein changes:
                  Total:  Added           57
                  Total:  Prev. Release   5757
                  Total:  Removed         3
                  Total:  This Release    5811
        Protein Removed:  WP_029728367.1  blaB            BlaB_family_subclass_B1_metallo-beta-lactamase
        Protein Removed:  WP_063842622.1  blaB            BlaB_family_subclass_B1_metallo-beta-lactamase
        Protein Removed:  WP_063842629.1  blaGOB          GOB_family_subclass_B3_metallo-beta-lactamase
          Protein Added:  AAA21095.1      arsB_R773       arsenite_efflux_transporter_membrane_subunit_ArsB
          Protein Added:  ABQ18953.1      emrD3           multidrug_efflux_MFS_transporter_EmrD-3
          Protein Added:  WP_000850833.1  emrD3           multidrug_efflux_MFS_transporter_EmrD-3
          Protein Added:  WP_010446567.1  tet(B)          tetracycline_efflux_MFS_transporter_Tet(B)
          Protein Added:  WP_039902635.1  blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-646
          Protein Added:  WP_063116263.1  arsB_R773       arsenite_efflux_transporter_membrane_subunit_ArsB
          Protein Added:  WP_063844329.1  dfrA12          trimethoprim-resistant_dihydrofolate_reductase_DfrA12
          Protein Added:  WP_063856066.1  tet(B)          tetracycline_efflux_MFS_transporter_Tet(B)
          Protein Added:  WP_063856068.1  tet(B)          tetracycline_efflux_MFS_transporter_Tet(B)
          Protein Added:  WP_070342370.1  dfrA7           trimethoprim-resistant_dihydrofolate_reductase_DfrA7
          Protein Added:  WP_071593205.1  aadA1bt         ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1bt
          Protein Added:  WP_071593208.1  aadA1bt         ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1bt
          Protein Added:  WP_086264536.1  blaOXA-213_like OXA-213_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-832
          Protein Added:  WP_094323230.1  mcr-2           phosphoethanolamine--lipid_A_transferase_MCR-2.3
          Protein Added:  WP_110174956.1  blaTEM          class_A_beta-lactamase_TEM-235
          Protein Added:  WP_125052736.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-834
          Protein Added:  WP_129336087.1  mcr-1           phosphoethanolamine--lipid_A_transferase_MCR-1.19
          Protein Added:  WP_135350920.1  blaGES          class_A_beta-lactamase_GES-41
          Protein Added:  WP_140423191.1  aac(6')-Ib      AAC(6')-Ib_family_aminoglycoside_6'-N-acetyltransferase
          Protein Added:  WP_140423278.1  aadA1           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA1
          Protein Added:  WP_140423279.1  aadA2           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2
          Protein Added:  WP_140423280.1  aadA2           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2
          Protein Added:  WP_140423281.1  aadA2           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA2
          Protein Added:  WP_140423282.1  aadA5           ANT(3'')-Ia_family_aminoglycoside_nucleotidyltransferase_AadA5
          Protein Added:  WP_140423283.1  dfrA1           trimethoprim-resistant_dihydrofolate_reductase_DfrA1
          Protein Added:  WP_140423284.1  dfrA12          trimethoprim-resistant_dihydrofolate_reductase_DfrA12
          Protein Added:  WP_140423285.1  dfrA17          trimethoprim-resistant_dihydrofolate_reductase_DfrA17
          Protein Added:  WP_140423286.1  dfrA17          trimethoprim-resistant_dihydrofolate_reductase_DfrA17
          Protein Added:  WP_140423287.1  dfrA17          trimethoprim-resistant_dihydrofolate_reductase_DfrA17
          Protein Added:  WP_140423305.1  blaADC          class_C_beta-lactamase_ADC-195
          Protein Added:  WP_140423306.1  blaB            subclass_B1_metallo-beta-lactamase_BlaB-15
          Protein Added:  WP_140423307.1  blaCMY          class_C_beta-lactamase_CMY-164
          Protein Added:  WP_140423308.1  blaFRI          carbapenem-hydrolyzing_class_A_beta-lactamase_FRI-8
          Protein Added:  WP_140423309.1  blaFRI          carbapenem-hydrolyzing_class_A_beta-lactamase_FRI-9
          Protein Added:  WP_140423310.1  blaIMI          carbapenem-hydrolyzing_class_A_beta-lactamase_IMI-19
          Protein Added:  WP_140423311.1  blaKPC          carbapenem-hydrolyzing_class_A_beta-lactamase_KPC-44
          Protein Added:  WP_140423312.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-643
          Protein Added:  WP_140423313.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-644
          Protein Added:  WP_140423314.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-645
          Protein Added:  WP_140423315.1  blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-647
          Protein Added:  WP_140423316.1  blaOXA-134_like OXA-134_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-648
          Protein Added:  WP_140423317.1  blaOXA-211_like OXA-211_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-650
          Protein Added:  WP_140423318.1  blaOXA-143_like OXA-143_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-825
          Protein Added:  WP_140423319.1  blaOXA-213_like OXA-213_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-826
          Protein Added:  WP_140423320.1  blaOXA-10_like  OXA-10_family_class_D_beta-lactamase_OXA-827
          Protein Added:  WP_140423321.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-828
          Protein Added:  WP_140423322.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-829
          Protein Added:  WP_140423323.1  blaOXA-51_like  OXA-51_family_carbapenem-hydrolyzing_class_D_beta-lactamase_OXA-831
          Protein Added:  WP_140423324.1  blaOXA-48_like  OXA-48_family_class_D_beta-lactamase_OXA-833
          Protein Added:  WP_140423325.1  blaPDC          class_C_beta-lactamase_PDC-333
          Protein Added:  WP_140423326.1  blaPOM          subclass_B3_metallo-beta-lactamase_POM-2
          Protein Added:  WP_140423327.1  blaVIM          subclass_B1_metallo-beta-lactamase_VIM-64
          Protein Added:  WP_140423328.1  blaVIM          subclass_B1_metallo-beta-lactamase_VIM-65
          Protein Added:  WP_140423329.1  mcr-1           phosphoethanolamine--lipid_A_transferase_MCR-1.20
          Protein Added:  WP_140423330.1  mcr-1           phosphoethanolamine--lipid_A_transferase_MCR-1.21
          Protein Added:  WP_140423331.1  mcr-3           phosphoethanolamine--lipid_A_transferase_MCR-3.26
          Protein Added:  WP_140423332.1  mcr-3           phosphoethanolamine--lipid_A_transferase_MCR-3.30
       Protein Modified:  ACM67153.1 lamda-2 intimin_type_lambda updated to ACM67153.1 lambda-2 intimin_type_lambda
       Protein Modified:  WP_001100753.1 blaPER class_A_extended-spectrum_beta-lactamase_PER-1 updated to WP_001100753.1 blaPER inhibitor-resistant_class_A_extended-spectrum_beta-lactamase_PER-1
       Protein Modified:  WP_002317273.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_002317273.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_002368697.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_002368697.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_032489743.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_032489743.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063856719.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856719.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063856723.1 vanR-B VanB-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856723.1 vanR-B VanB-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063856729.1 vanR-O VanO-type_vancomycin_resistance_DNA-binding_response_regulator_VanR updated to WP_063856729.1 vanR-O VanO-type_vancomycin_resistance_response_regulator_transcription_factor_VanR
       Protein Modified:  WP_063860636.1 blaKPC carbapenem-hydrolyzing_class_A_beta-lactamase_KPC-14 updated to WP_063860636.1 blaKPC inhibitor-resistant_class_A_extended-spectrum_beta-lactamase_KPC-14
- AMR HMM library Changes:
                  Total:  Added           5
                  Total:  Prev. Release   610
                  Total:  Removed         12
                  Total:  This Release    603
            HMM Removed:  NF000252.1      MexX
            HMM Removed:  NF000282.2      RND_permease_1
            HMM Removed:  NF000314.1      adeB
            HMM Removed:  NF000315.1      adeC-adeK-oprM
            HMM Removed:  NF007842.1      PRK10555.1
            HMM Removed:  NF011706.2      PRK15127.1
            HMM Removed:  NF028537.1      P_eth_NH2_trans
            HMM Removed:  NF033086.2      penta_rpt_Qnr
            HMM Removed:  NF033134.0      cmlA_floR
            HMM Removed:  NF033143.1      efflux_OM_AdeK
            HMM Removed:  NF033643.1      EspJ_gen
            HMM Removed:  NF033651.1      cyto_nec_fctrs
              HMM Added:  NF000478.2      linco_LnuE
              HMM Added:  NF012180.1      tet_MFS_43
              HMM Added:  NF033866.1      blaCDD
              HMM Added:  NF033867.1      blaPAU
              HMM Added:  NF033868.0      trim_DfrA36
- Protein family changes:
                  Total:  Added           11
                  Total:  Prev. Release   1449
                  Total:  Removed         6
                  Total:  This Release    1454
         Family Removed:  NF011706.2      acrB
         Family Removed:  NF007842.1      acrD
         Family Removed:  NF000314.1      adeB/adeJ
         Family Removed:  NF033143.1      adeK
         Family Removed:  -               lamda
         Family Removed:  -               lamda-2
           Family Added:  -               aadA1bt
           Family Added:  -               arsB
           Family Added:  -               arsB_R773
           Family Added:  NF033866.1      blaCDD
           Family Added:  NF033867.1      blaPAU
           Family Added:  NF033868.0      dfrA36
           Family Added:  -               emrD3
           Family Added:  -               lambda
           Family Added:  -               lambda-2
           Family Added:  NF000478.2      lnu(E)
           Family Added:  NF012180.1      tet(43)
         Family Changed:  NF030466.1 MerP_Gneg updated to TIGR02052.1 MerP_Gneg
         Family Changed:  NF030467.1 merA updated to TIGR02053.1 merA


---------------------------------------------------------------------
Changes included in 2019-06-18.1
---------------------------------------------------------------------

This the first alpha release of the AMRFinderPlus database. For this and all
following releases there is a distinction between "core" proteins which
correspond to the genes that would previously have been reported by AMRFinder
and "plus" proteins that are new genes and classes of genes. The "core"
designation is given to proteins where we believe their presence is likely to
have an important effect on antimicrobial resistance.

* Screen for select point mutations for antibiotic resistance from Salmonella,
    E. coli, and Campylobacter
    * Protein mutations in: 50S_L22 protein, acrB, acrR, basR, cmeR, cyaA,
      fabG, fabI, folP, gyrA, gyrB, lon, marR, murA, nfsA, ompF, parC, parE,
      pmrA, pmrB, ptsI, ramR, rpoB, rpsL, soxR, soxS, tufA, uhpA, uhpT
    * Nucleotide mutations in 16S and 23S rRNA
    * Included point mutations are listed in the reference gene database
      (https://www.ncbi.nlm.nih.gov/pathogens/isolates#/refgene/)
* New "Plus" genes
    * virulence factors
    * biocide resistance
    * metal resistance
    * heat resistance
    * acid resistance
* Combined and integrated results from nucleotide and protein searches

File formats have changed significantly. See https://github.com/evolarjun/amr/wiki
for details.

Since release 2019-04-29.1 only one change has been made to the core AMR
proteins. Qac's are now categorized under Type STRESS and Subtype BIOCIDE.

- Protein changes:
      Prev. Release:  4942
       This Release:  5718
              Added:   776
           Modified:     0

      Protein Added: ABF69110.1     eae      intimin type beta
      Protein Added: ABF69117.1     eae      intimin type epsilon
      Protein Added: ABF69121.1     eae      intimin type epsilon
      Protein Added: ABF69122.1     eae      intimin type alpha
      Protein Added: KYU89760.1     subB     subtilase AB5 cytotoxin subunit B
      Protein Added: AAG16664.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAG16667.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAG16676.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAB09625.1     arsD     arsenite efflux transporter metallochaperone ArsD
      Protein Added: AAB09626.1     arsA     arsenite efflux transporter ATPase subunit ArsA
      Protein Added: CAJ76690.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAJ76692.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: AAA98291.1     terC     tellurium resistance membrane protein TerC
      Protein Added: AAA98293.1     terE     tellurium resistance cAMP binding protein TerE
      Protein Added: AAG27731.1     norM     sodium-coupled multidrug efflux MATE transporter NorM
      Protein Added: ABF02983.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABF04028.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: BAE98279.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: BAE98281.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: CAC14596.1     smeF     multidrug efflux RND transporter outer membrane subunit SmeF
      Protein Added: AAA83973.1     merR1    mercury resistance transcriptional regulator MerR1
      Protein Added: AAA83975.1     merT     mercuric transport protein MerT
      Protein Added: AAA98292.1     terD     tellurium resistance membrane protein TerD
      Protein Added: AAG34504.1     perA     BFP system transcriptional regulator PerA
      Protein Added: APX31172.1     yfdX1    heat resistance protein YfdX1
      Protein Added: APX31174.1     hdeD-GI  heat resistance membrane protein HdeD-GI
      Protein Added: APX31176.1     trxLHR   heat resistance system thioredoxin Trx-GI
      Protein Added: APX31177.1     kefB-GI  heat resistance system K+/H+ antiporter KefB-GI
      Protein Added: APX31178.1     psi-GI   heat resistance protein PsiE-GI
      Protein Added: AAA85087.1     f17a     F17A fimbrial adhesin
      Protein Added: AAA85196.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: AAG37043.1     espC     serine protease autotransporter toxin EspC
      Protein Added: ABI93207.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: BAF33872.1     capU     putative hexosyltransferase CapU
      Protein Added: BAF33878.1     aggR     aggregative adherence transcriptional regulator AggR
      Protein Added: BAF33885.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: BAF33888.1     agg4D    aggregative adherence fimbria 4 chaperone Agg4D/HdaD
      Protein Added: BAF33891.1     agg4A    aggregative adherence fimbria 4 major subunit Agg4A/HdaA
      Protein Added: BAF33901.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: BAF34018.1     aap      dispersin Aap
      Protein Added: ABJ00546.1     iss      increased serum survival lipoprotein Iss
      Protein Added: ABJ02430.1     ireA     TonB-dependent siderophore receptor IreA
      Protein Added: OPH66324.1     lpfA1    long polar fimbria major subunit LpfA1
      Protein Added: ABJ90288.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAA86846.1     terZ     tellurium resistance-associated protein TerZ
      Protein Added: ABC67318.2     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAG40758.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAA88371.1     merE     broad-spectrum mercury transporter MerE
      Protein Added: AAG42788.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ASF80766.1     yfdX2    heat resistance protein YfdX2
      Protein Added: ASF80771.1     shsP     small heat shock protein sHSP20-GI
      Protein Added: CAM11313.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11314.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11315.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11317.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11321.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11323.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11324.1     nleA     type III secretion system effector NleA
      Protein Added: CAM11325.1     nleA     type III secretion system effector NleA
      Protein Added: AAA92618.1     f17a     F17A fimbrial adhesin
      Protein Added: AAA92621.1     f17g     F17G fimbrial adhesin
      Protein Added: AAA93060.1     arsD     arsenite efflux transporter metallochaperone ArsD
      Protein Added: AAG53662.1     perA     BFP system transcriptional regulator PerA
      Protein Added: BAF45432.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: BAF45437.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45439.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45440.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45447.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45451.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF45459.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: ABM90581.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90583.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90587.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90589.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90597.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90605.1     perA     BFP system transcriptional regulator PerA
      Protein Added: ABM90615.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAC46147.1     yfeA     iron/manganese ABC transporter substrate-binding protein YfeA
      Protein Added: AAC46148.1     yfeB     iron/manganese ABC transporter ATP-binding protein YfeB
      Protein Added: AAC46150.1     yfeD     iron/manganese ABC transporter permease subunit YfeD
      Protein Added: ATE69525.1     acr3     arsenite efflux transporter Acr3
      Protein Added: AAG55141.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: AAG56990.1     espJ     type III secretion system effector ADP-ribosyltransferase EspJ
      Protein Added: AAG58695.1     lpfA1    long polar fimbria major subunit LpfA1
      Protein Added: AAG58814.1     espF     type III secretion system LEE effector EspF
      Protein Added: AAG58818.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAG58825.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAK15050.1     ttgR     efflux transport transcriptional regulator TtgR
      Protein Added: AAK16940.1     nleA     type III secretion system effector NleA
      Protein Added: AAK17180.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: AAK18385.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAK18444.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: BAB37280.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAB38093.1     lpfA2    long polar fimbria major subunit LpfA2
      Protein Added: AAC44736.1     terW     tellurium resistance protein TerW
      Protein Added: AVL28824.1     aar      AggR-activated transcriptional regulator Aar
      Protein Added: SPD96882.1     silS     copper/silver sensor histidine kinase SilS
      Protein Added: SPD96883.1     silR     copper/silver response regulator transcription factor SilR
      Protein Added: SPD96884.1     silC     Cu(+)/Ag(+) efflux RND transporter outer membrane channel SilC
      Protein Added: CAA57177.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA57175.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA57173.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA57171.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: BAB43874.1     cadD     cadmium resistance transporter CadD
      Protein Added: AAK48830.1     cadR     cadmium resistance transcriptional regulator CadR
      Protein Added: BAF52034.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52035.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52033.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52358.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52360.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52362.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52363.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52364.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52365.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52366.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52367.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52370.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52374.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52377.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAF52548.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: BAF52549.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: BAB47641.1     merB     organomercurial lyase MerB
      Protein Added: AAK56853.1     chrR     class I chromate reductase ChrR
      Protein Added: CAC39286.1     espI     serine protease autotransporter EspI
      Protein Added: AAA83977.1     merA     mercury(II) reductase
      Protein Added: AAA23405.1     fasA     F6 fimbrial major subunit FasA
      Protein Added: AAA23421.1     fim41a   fimbrial adhesin F41 protein Fim41a
      Protein Added: AAK66972.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAC41416.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: CAB54534.2     mchB     microcin H47
      Protein Added: AAK69562.1     srpS     solvent efflux transporter transcriptional repressor SrpS
      Protein Added: AAA23734.1     fedA     F18 fimbrial major subunit FedA
      Protein Added: ABQ02454.1     eae      intimin type rho
      Protein Added: AAA24032.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAA24035.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAA24390.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AXV27948.1     agg3C    aggregative adherence fimbria 3 usher protein Agg3C
      Protein Added: AAA19189.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAA19190.1     stx2Be   Shiga toxin Stx2e subunit B
      Protein Added: AAA24632.1     stx2Af   Shiga toxin Stx2f subunit A
      Protein Added: AAA24633.1     stx2Bf   Shiga toxin Stx2f subunit B
      Protein Added: AAA71893.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: AAA71894.1     stx1Ba   Shiga toxin Stx1a subunit B
      Protein Added: AAA24653.1     sta1     heat-stable enterotoxin ST-I group a
      Protein Added: ABR09925.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR09934.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ABR09935.1     stx2Bc   Shiga toxin Stx2c subunit B
      Protein Added: ABR09936.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: ABR09937.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: ABR09945.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR09961.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR09963.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: ABR10024.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAA30714.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: CAA30715.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: AAB59075.1     merT     mercuric transport protein MerT
      Protein Added: AAA88369.1     merB     organomercurial lyase MerB
      Protein Added: AAA88370.1     merD     mercury resistance co-regulator MerD
      Protein Added: AAA98222.1     merT     mercuric transport protein MerT
      Protein Added: AAA98223.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: AAA25638.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: AAA88432.1     chrA     chromate resistance efflux protein ChrA
      Protein Added: AAA25803.1     copR     heavy metal response regulator transcription factor CopR
      Protein Added: AAA25804.1     copS     copper resistance membrane spanning protein CopS
      Protein Added: AAA25806.1     copA     laccase-like oxidase CopA
      Protein Added: AAA25807.1     copB     copper-binding protein CopB
      Protein Added: CAC48396.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAC48398.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAA21094.1     arsA     arsenite efflux transporter ATPase subunit ArsA
      Protein Added: BAB62897.1     cofA     type IV pilus CFA/III major pilin
      Protein Added: BAB62907.1     cofA     type IV pilus CFA/III major pilin
      Protein Added: CAA63849.1     ehxA     enterohemolysin
      Protein Added: AAA26402.1     klaB     tellurium resistance system protein klaB
      Protein Added: AAA26403.1     klaC     tellurium resistance system protein klaC
      Protein Added: AAK97136.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: AAK99679.1     pmrA     multidrug efflux MFS transporter PmrA
      Protein Added: CAC69248.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: CAC69249.1     merT     mercuric transport protein MerT
      Protein Added: CAC69250.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: CAC69251.1     merA     mercury(II) reductase
      Protein Added: BAB64566.1     bexA     multidrug efflux MATE transporter BexA
      Protein Added: AAA27589.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: ABU55302.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: BAF76383.1     ttgA     toluene efflux RND transporter periplasmic adaptor subunit TtgA
      Protein Added: BAF76384.1     ttgB     multidrug efflux RND transporter permease subunit TtgB
      Protein Added: ABV01314.1     ltcA     heat-labile enterotoxin LT subunit A
      Protein Added: BAF79679.1     smdA     multidrug efflux ABC transporter permease/ATP-binding subunit SmdA
      Protein Added: BAF79680.1     smdB     multidrug efflux ABC transporter permease/ATP-binding subunit SmdB
      Protein Added: ABV16438.1     eatA     serine protease autotransporter toxin EatA
      Protein Added: BAB68369.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: BAB68370.1     stx2Bc   Shiga toxin Stx2c subunit B
      Protein Added: BAF80121.1     ssmE     multidrug efflux SMR transporter SsmE
      Protein Added: AAL06376.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAL06381.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AAL06387.1     espF     type III secretion system LEE effector EspF
      Protein Added: AAC23256.1     hmrM     sodium-coupled multidrug efflux MATE transporter HmrM
      Protein Added: ABQ02442.1     ehxA     enterohemolysin
      Protein Added: ABQ02443.1     ehxA     enterohemolysin
      Protein Added: ABQ02445.1     ehxA     enterohemolysin
      Protein Added: ABQ02447.1     ehxA     enterohemolysin
      Protein Added: ABQ02448.1     ehxA     enterohemolysin
      Protein Added: AAL08400.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: BAF92845.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAL14441.1     adeC     multidrug efflux RND transporter AdeABC outer membrane channel subunit AdeC
      Protein Added: CAP17609.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAP17610.1     stx2Be   Shiga toxin Stx2e subunit B
      Protein Added: AAL18821.1     epeA     serine protease autotransporter EpeA
      Protein Added: AAL19305.1     mdsB     multidrug efflux RND transporter permease subunit MdsB
      Protein Added: AAL19306.1     mdsA     multidrug efflux RND transporter periplasmic adaptor subunit MdsA
      Protein Added: AAL19307.1     golT     gold/copper-translocating P-type ATPase GolT
      Protein Added: AAL19308.1     golS     Au(I) sensor transcriptional regulator GolS
      Protein Added: BAF96525.1     espJ     type III secretion system effector ADP-ribosyltransferase EspJ
      Protein Added: BAF96538.1     nleB2    type III secretion system effector arginine glycosyltransferase NleB2
      Protein Added: BAF96541.1     nleA     type III secretion system effector NleA
      Protein Added: BAA18405.1     acr3     arsenite efflux transporter Acr3
      Protein Added: BAA18407.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: AAL26283.1     saa      autoagglutinating adhesin Saa
      Protein Added: CAA65654.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAC45964.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAC45965.1     stx2Be   Shiga toxin Stx2e subunit B
      Protein Added: ACA34793.1     tsh      temperature-sensitive protease autotransporter hemagglutinin Tsh
      Protein Added: BAG11995.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: BAG11997.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: BAG12001.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: ACB16424.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: ACB16655.1     eilA     HilA family transcriptional regulator EilA
      Protein Added: ACB17037.1     air      inverse autotransporter adhesin EaeX/Air
      Protein Added: CAA70196.1     merT     mercuric transport protein MerT
      Protein Added: ACB72721.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAC44731.1     espC     serine protease autotransporter toxin EspC
      Protein Added: AAC74250.1     ymgB     biofilm/acid-resistance regulator AriR
      Protein Added: AAC76298.1     acrF     multidrug efflux RND transporter permease subunit AcrF
      Protein Added: AAC77293.1     mdtM     multidrug efflux MFS transporter MdtM
      Protein Added: AAL57565.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAB82994.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB82996.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB82998.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB83000.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAB83002.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: BAB83003.1     stx2Bg   Shiga toxin Stx2g subunit B
      Protein Added: BAB83005.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: BAB83007.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: BAB83020.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: BAB83022.1     stx1Ac   Shiga toxin Stx1c subunit A
      Protein Added: BAB83023.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: BAB83024.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: AAL72309.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAL72350.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: AAL05407.1     tcrB     copper-translocating P-type ATPase TcrB
      Protein Added: ACD06066.1     capU     putative hexosyltransferase CapU
      Protein Added: ACD06132.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: ACD07996.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: ACD09076.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: BAA11821.1     chrR     class I chromate reductase ChrR
      Protein Added: CAQ45062.1     emrC     multidrug efflux transporter outer membrane subunit EmrC
      Protein Added: CAQ45063.1     emrA     multidrug efflux MFS transporter periplasmic adaptor subunit EmrA
      Protein Added: CAQ45064.1     emrB     multidrug efflux MFS transporter permease subunit EmrB
      Protein Added: ACF05260.1     agg4A    aggregative adherence fimbria 4 major subunit Agg4A/HdaA
      Protein Added: ACF30254.1     mtrR     multidrug efflux system transcriptional repressor MtrR
      Protein Added: ACF30256.1     mtrF     AbgT family antimetabolite efflux transporter MtrF
      Protein Added: BAG66379.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAG66729.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: BAG66736.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG59623.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG59674.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: ACG59676.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: ACG59681.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG59730.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: ACG59732.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: ACG59737.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACG76368.1     arsP     organoarsenical efflux permease ArsP
      Protein Added: ACI12150.1     terB     tellurium resistance membrane protein TerB
      Protein Added: BAG76115.1     iss      increased serum survival lipoprotein Iss
      Protein Added: AAA98099.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAS08589.1     nleB2    type III secretion system effector arginine glycosyltransferase NleB2
      Protein Added: CAS08990.1     nleA     type III secretion system effector NleA
      Protein Added: CAS10463.1     espC     serine protease autotransporter toxin EspC
      Protein Added: CAS06720.1     eae      intimin type gamma
      Protein Added: CAS06721.1     eae      intimin type alpha
      Protein Added: CAS06723.1     eae      intimin type alpha
      Protein Added: BAA20334.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: BAA20336.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: BAA20337.1     merA     mercury(II) reductase
      Protein Added: AAM70045.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: CAQ87187.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: CAV00478.1     lpfA     long polar fimbria major subunit LpfA
      Protein Added: CAV00812.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: CAV02025.1     capU     putative hexosyltransferase CapU
      Protein Added: CAQ90194.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CAU95796.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: CAU95824.1     agg3D    aggregative adherence fimbria 3 chaperone Agg3D
      Protein Added: CAQ97644.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CAR01635.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: CAR09703.2     ireA     TonB-dependent siderophore receptor IreA
      Protein Added: CAR12622.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CAR15326.1     air      inverse autotransporter adhesin EaeX/Air
      Protein Added: CAW30811.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: CAW30815.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: ACL13561.1     copR     heavy metal response regulator transcription factor CopR
      Protein Added: ACL13562.1     copS     copper resistance membrane spanning protein CopS
      Protein Added: ACL51961.1     ehxA     enterohemolysin
      Protein Added: ACL51990.1     toxB     toxin B
      Protein Added: AAM88296.1     agg3C    aggregative adherence fimbria 3 usher protein Agg3C
      Protein Added: AAM88297.1     agg3B    aggregative adherence fimbria 3 minor subunit Agg3B
      Protein Added: AAM88298.1     agg3A    aggregative adherence fimbria 3 major subunit Agg3A
      Protein Added: AAM88299.1     astA     heat-stable enterotoxin EAST1
      Protein Added: AAM88302.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: BAA14138.2     merC     organomercurial transporter MerC
      Protein Added: AAM88668.1     cueA     copper resistance metal-translocating P1-type ATPase CueA
      Protein Added: AAM90978.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: CAX18553.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: CAX18626.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: CAX18635.1     espF     type III secretion system LEE effector EspF
      Protein Added: CAX18641.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAX18646.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: CAX18721.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAX18726.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ACM67143.1     eae      intimin type alpha
      Protein Added: ACM67145.1     eae      intimin type iota
      Protein Added: ACM67146.1     eae      intimin type alpha
      Protein Added: ACM67148.1     eae      intimin type gamma
      Protein Added: ACM67149.1     eae      intimin type gamma
      Protein Added: ACM67152.1     eae      intimin type beta
      Protein Added: ACM67153.1     eae      intimin type lambda
      Protein Added: ACM67154.1     eae      intimin type gamma
      Protein Added: ACM67155.1     eae      intimin type epsilon
      Protein Added: ACM67156.1     eae      intimin type epsilon
      Protein Added: ACM67157.1     eae      intimin type beta
      Protein Added: ACM67158.1     eae      intimin type epsilon
      Protein Added: ACM67160.1     eae      intimin type beta
      Protein Added: ACM67161.1     eae      intimin type beta
      Protein Added: ACM67162.1     eae      intimin type gamma
      Protein Added: ACM67163.1     eae      intimin type rho
      Protein Added: ACM67164.1     eae      intimin type gamma
      Protein Added: ACM67165.1     eae      intimin type gamma
      Protein Added: ACM67166.1     eae      intimin type gamma
      Protein Added: ACM67167.1     eae      intimin type epsilon
      Protein Added: ACM67168.1     eae      intimin type alpha
      Protein Added: ACM67169.1     eae      intimin type gamma
      Protein Added: ACM67172.1     eae      intimin type epsilon
      Protein Added: ACM67177.1     eae      intimin type gamma
      Protein Added: ACM67178.1     eae      intimin type epsilon
      Protein Added: BAH24012.1     toxB     toxin B
      Protein Added: CAB14520.2     acr3     arsenite efflux transporter Acr3
      Protein Added: ACO06752.1     emhB     efflux RND transporter permease subunit EmhB
      Protein Added: AAN03785.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: AAN03786.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: AAN04250.1     dpsA     non-specific DNA-binding protein DpsA
      Protein Added: BAC10987.1     stx1Ac   Shiga toxin Stx1c subunit A
      Protein Added: BAC10988.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: BAC10992.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: CAY54182.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: AAN29240.1     bepD     multidrug efflux RND transporter periplasmic adaptor subunit BepD
      Protein Added: AAN29241.1     bepE     multidrug efflux RND transporter permease subunit BepE
      Protein Added: AAN29871.1     bepC     multidrug efflux RND transporter outer membrane subunit BepC
      Protein Added: AAN33534.1     bepG     multidrug efflux RND transporter permease subunit BepG
      Protein Added: AAN33535.1     bepF     multidrug efflux RND transporter periplasmic adaptor subunit BepF
      Protein Added: CAD48850.1     cdtB     cytolethal distending toxin type III/V nuclease subunit CdtB
      Protein Added: CAC86907.1     merB     organomercurial lyase MerB
      Protein Added: BAH65949.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: BAH72965.1     cdtB     cytolethal distending toxin type II nuclease subunit CdtB
      Protein Added: AAN42986.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: AAN43435.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: AAN44449.1     sigA     serine protease autotransporter toxin SigA
      Protein Added: CAQ68302.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ACS88189.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: AAC45719.1     f17a     F17A fimbrial adhesin
      Protein Added: AAC45722.1     f17g     F17G fimbrial adhesin
      Protein Added: AAN68576.1     mrdH     Ni(II)/Co(II) efflux transporter permease subunit MrdH
      Protein Added: AAN68577.1     mreA     metal-sensing transcriptional repressor MreA
      Protein Added: ACT33468.1     f17a     F17A fimbrial adhesin
      Protein Added: ACT33471.1     f17g     F17G fimbrial adhesin
      Protein Added: ACT72391.1     tccP     Tir-cytoskeleton coupling protein TccP
      Protein Added: CAR47993.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAR48009.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAH86759.1     stx2Af   Shiga toxin Stx2f subunit A
      Protein Added: BAH86760.1     stx2Bf   Shiga toxin Stx2f subunit B
      Protein Added: BAA20338.2     merB     organomercurial lyase MerB
      Protein Added: ACU32684.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: ACU65296.1     merA     mercury(II) reductase
      Protein Added: CAX45702.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAX45706.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: CAX45714.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAX45718.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAX45737.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: CAX45739.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: CAX45746.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: CAX51714.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: AAB82330.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAI25473.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: BAI31154.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: BAI32292.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAI32327.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: BAI32516.1     espI     serine protease autotransporter EspI
      Protein Added: BAI33940.1     etpD     variant type II secretion system secretin EtpD
      Protein Added: BAI36256.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: BAI36790.1     nleA     type III secretion system effector NleA
      Protein Added: BAI37513.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: BAI37519.1     espF     type III secretion system LEE effector EspF
      Protein Added: BAI37525.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: BAA23166.1     merG     phenylmercury resistance protein MerG
      Protein Added: AAN76093.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAN77057.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAN77061.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAN77063.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: BAI44131.1     agg5A    aggregative adherence fimbria V major subunit Agg5A
      Protein Added: AAD12176.1     srpB     solvent efflux RND transporter permease subunit SrpB
      Protein Added: AAD12177.1     ttgI     solvent efflux RND transporter outer membrane subunit SrpC
      Protein Added: AAD12178.1     srpA     solvent efflux RND transporter periplasmic adaptor subunit SrpA
      Protein Added: AAN78874.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: AAN79707.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAN80033.1     iss      increased serum survival lipoprotein Iss
      Protein Added: AAN83596.1     ireA     TonB-dependent siderophore receptor IreA
      Protein Added: CAB14519.1     arsC     thioredoxin-dependent arsenate reductase
      Protein Added: AAB91079.1     copB     copper-binding protein CopB
      Protein Added: CAA05105.1     copP     copper-binding metallochaperone CopP
      Protein Added: AAB88410.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: EEZ94110.1     sdeA     multidrug efflux RND transporter periplasmic adaptor subunit SdeA
      Protein Added: AAO17297.1     eatA     serine protease autotransporter toxin EatA
      Protein Added: ADA73787.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: ADA76801.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAO19475.1     stx1Ad   Shiga toxin Stx1d subunit A
      Protein Added: AAO19476.1     stx1Bd   Shiga toxin Stx1d subunit B
      Protein Added: ADA79992.1     merT     mercuric transport protein MerT
      Protein Added: CBG87859.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: CBG89712.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAD66214.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: ADB20445.1     toxB     toxin B
      Protein Added: CBG36837.1     eilA     HilA family transcriptional regulator EilA
      Protein Added: CBG36838.1     air      inverse autotransporter adhesin EaeX/Air
      Protein Added: CBG37385.1     aaiC     type VI secretion system protein AaiC/Hcp2
      Protein Added: CBG27762.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: CBG27784.1     aafB     aggregative adherence fimbria II minor subunit AafB
      Protein Added: CBG27798.1     aafD     aggregative adherence fimbria II chaperone AafD
      Protein Added: CBG27800.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: CBG27804.1     aggR     aggregative adherence transcriptional regulator AggR
      Protein Added: CBG27807.1     aap      dispersin Aap
      Protein Added: CBG27812.1     aar      AggR-activated transcriptional regulator Aar
      Protein Added: AAD12174.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: AAO49780.1     ttgD     toluene efflux RND transporter periplasmic adaptor subunit TtgD
      Protein Added: AAC38390.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAC38394.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AAC38400.1     espF     type III secretion system LEE effector EspF
      Protein Added: BAA24822.1     arsA     arsenite efflux transporter ATPase subunit ArsA
      Protein Added: AAA20885.1     astA     heat-stable enterotoxin EAST1
      Protein Added: AAA23736.1     f17g     F17G fimbrial adhesin
      Protein Added: AAA23737.1     f17a     F17A fimbrial adhesin
      Protein Added: ADD58872.1     espF     type III secretion system LEE effector EspF
      Protein Added: ADD58881.1     eae      intimin type gamma
      Protein Added: ADD58883.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: EFF39147.1     norM     sodium-coupled multidrug efflux MATE transporter NorM
      Protein Added: AAO66617.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: BAJ04486.1     perA     BFP system transcriptional regulator PerA
      Protein Added: BAJ04488.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAC38219.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: AAC38220.1     merA     mercury(II) reductase
      Protein Added: AAC38221.1     merD     mercury resistance co-regulator MerD
      Protein Added: ADE90928.1     vactox   vacuolating autotransporter toxin Vat
      Protein Added: AAC38229.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: AAC38230.1     merB     organomercurial lyase MerB
      Protein Added: AAC38231.1     merT     mercuric transport protein MerT
      Protein Added: AAC38232.1     merP     mercury resistance system periplasmic binding protein MerP
      Protein Added: AAC38233.1     merC     organomercurial transporter MerC
      Protein Added: AAC38236.1     merE     broad-spectrum mercury transporter MerE
      Protein Added: ADF64798.1     ncrC     Ni(II)/Co(II) efflux transporter permease subunit NcrC
      Protein Added: CBK85583.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: CBL93318.1     capU     putative hexosyltransferase CapU
      Protein Added: CBL93506.1     lngA     type IV pilus longus major pilin
      Protein Added: ADI59685.1     astA     heat-stable enterotoxin EAST1
      Protein Added: ADI95409.1     ttgE     multidrug efflux RND transporter permease subunit TtgE
      Protein Added: ADI95411.1     ttgT     efflux transport transcriptional regulator TtgT
      Protein Added: AAP03990.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAP18950.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: ADK23698.1     qacR     multidrug-binding transcriptional regulator QacR
      Protein Added: ADK73987.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAM22256.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAM22257.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: CAD56174.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAD56186.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAA16360.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: AAA16361.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: AAA16362.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ADM83435.1     nleA     type III secretion system effector NleA
      Protein Added: ADN71659.1     iss      increased serum survival lipoprotein Iss
      Protein Added: AAP37403.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: AAC26634.1     pet      serine protease autotransporter toxin Pet
      Protein Added: CBJ04488.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: AAC15683.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ADO96486.1     hmrM     sodium-coupled multidrug efflux MATE transporter HmrM
      Protein Added: ADP02162.1     merA     mercury(II) reductase
      Protein Added: CAA73506.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: ADR26561.1     iss      increased serum survival lipoprotein Iss
      Protein Added: ADR70747.1     copA     laccase-like oxidase CopA
      Protein Added: ADR70748.1     copB     copper-binding protein CopB
      Protein Added: BAC77251.1     sdeY     multidrug efflux RND transporter permease subunit SdeY
      Protein Added: ADW66881.1     arsH     arsenic resistance NADPH-dependent reductase ArsH
      Protein Added: AAP78989.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: BAC78639.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: BAC78640.1     stx1Ba   Shiga toxin Stx1a subunit B
      Protein Added: AAC69314.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAC69318.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: BAJ79293.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79295.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79296.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79297.1     aafA     aggregative adherence fimbria II major subunit AafA
      Protein Added: BAJ79299.1     agg5A    aggregative adherence fimbria V major subunit Agg5A
      Protein Added: BAJ79300.1     agg5A    aggregative adherence fimbria V major subunit Agg5A
      Protein Added: ADY84088.1     nreB     nickel resistance MFS transporter NreB
      Protein Added: AAC24352.1     ehxA     enterohemolysin
      Protein Added: ADZ45128.1     ehxA     enterohemolysin
      Protein Added: AAP88295.1     copA     laccase-like oxidase CopA
      Protein Added: AEC46567.1     copA     laccase-like oxidase CopA
      Protein Added: AEC46568.1     copB     copper-binding protein CopB
      Protein Added: AAC38671.1     ttgB     multidrug efflux RND transporter permease subunit TtgB
      Protein Added: BAA31774.1     ehxA     enterohemolysin
      Protein Added: BAA31815.1     toxB     toxin B
      Protein Added: BAA31832.1     katP     catalase/peroxidase KatP
      Protein Added: BAA31836.1     espP     serine protease autotransporter EspP
      Protein Added: AAQ17236.1     mco      multi-copper oxidase Mco
      Protein Added: AAQ17546.1     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAA74174.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AEG95593.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAQ20107.1     cfaC     CFA/I pilus usher protein CfaC
      Protein Added: AEK01061.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAC31499.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAY90617.2     emhA     efflux RND transporter periplasmic adaptor subunit EmhA
      Protein Added: CAA12346.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA12348.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AEM17342.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: AAC33154.1     lngA     type IV pilus longus major pilin
      Protein Added: AEQ14997.1     eilA     HilA family transcriptional regulator EilA
      Protein Added: AEQ15694.1     capU     putative hexosyltransferase CapU
      Protein Added: AAC33908.1     merC     organomercurial transporter MerC
      Protein Added: CCE21264.1     agg3A    aggregative adherence fimbria 3 major subunit Agg3A
      Protein Added: EHE72460.1     pmrA     multidrug efflux MFS transporter PmrA
      Protein Added: EHF16244.1     aatA     dispersin export ABC transporter outer membrane protein AatA
      Protein Added: EHF16297.1     aggB     aggregative adherence fimbria I minor subunit AggB
      Protein Added: EHF16298.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: AET11941.1     nleA     type III secretion system effector NleA
      Protein Added: AET11995.1     nleA     type III secretion system effector NleA
      Protein Added: AET12008.1     nleA     type III secretion system effector NleA
      Protein Added: BAL46940.1     eae      intimin type alpha
      Protein Added: BAL46941.1     eae      intimin type epsilon
      Protein Added: BAL47132.1     eae      intimin type epsilon
      Protein Added: BAL47176.1     eae      intimin type rho
      Protein Added: BAL47179.1     eae      intimin type epsilon
      Protein Added: BAL47181.1     eae      intimin type alpha
      Protein Added: AEZ42789.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AEZ43710.1     nleA     type III secretion system effector NleA
      Protein Added: AAQ92182.1     emhC     efflux RND transporter outer membrane subunit EmhC
      Protein Added: CAA77068.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: AAR02190.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: BAL72684.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: BAL72697.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: AAR12207.1     cdtB     cytolethal distending toxin type III/V nuclease subunit CdtB
      Protein Added: AAC69584.1     ybtQ     yersiniabactin ABC transporter ATP-binding/permease protein YbtQ
      Protein Added: AAR13270.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AFH14350.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: CAD87828.1     sta1     heat-stable enterotoxin ST-I group a
      Protein Added: BAA34299.1     mexX     multidrug efflux RND transporter periplasmic adaptor subunit MexX
      Protein Added: AFK88558.1     auto-sat serine protease autotransporter toxin Sat
      Protein Added: AFM31243.1     tccP     Tir-cytoskeleton coupling protein TccP2
      Protein Added: AFM70729.1     copA     copper-translocating P-type ATPase CopA
      Protein Added: AFM70730.1     copB     copper/silver-translocating P-type ATPase CopB
      Protein Added: AAC82360.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: AAR82963.1     nirA     nickel resistance membrane nickel efflux protein NirA
      Protein Added: AAR82964.1     nirB     nickel-sensing transcriptional repressor NirB
      Protein Added: AAR82966.1     nirD     nickel resistance OB fold protein NirD
      Protein Added: AFQ65076.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAA50007.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: CAA12345.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA12350.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA12351.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AFS59871.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AFS85685.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAC99337.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAA21388.1     ybtP     yersiniabactin ABC transporter ATP-binding/permease protein YbtP
      Protein Added: BAA36431.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: BAA36433.1     merD     mercury resistance co-regulator MerD
      Protein Added: CAA40744.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAA23532.1     ltcA     heat-labile enterotoxin LT subunit A
      Protein Added: CAA32535.1     fim41a   fimbrial adhesin F41 protein Fim41a
      Protein Added: AAD05936.1     copP     copper-binding metallochaperone CopP
      Protein Added: AAS07580.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07581.1     stx2Bc   Shiga toxin Stx2c subunit B
      Protein Added: AAS07582.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07586.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAS07588.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAS07589.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: AAS07590.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07596.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAS07600.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAS07606.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAD11743.1     silE     silver-binding protein SilE
      Protein Added: AAD11746.1     silC     Cu(+)/Ag(+) efflux RND transporter outer membrane channel SilC
      Protein Added: AAD11748.1     silB     Cu(+)/Ag(+) efflux RND transporter periplasmic adaptor subunit SilB
      Protein Added: AAD11749.1     silA     Cu(+)/Ag(+) efflux RND transporter permease subunit SilA
      Protein Added: AAD11750.1     silP     Ag(+)-translocating P-type ATPase SilP
      Protein Added: AFX83959.1     subA     subtilase AB5 cytotoxin subunit A
      Protein Added: AAS21297.1     tbtR     tribuytltin resistance regulator TbtR
      Protein Added: CAA43585.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAD15663.1     tbtA     multidrug efflux RND transporter periplasmic adaptor subunit TbtA
      Protein Added: AAD15664.1     tbtB     multidrug efflux RND transporter permease subunit TbtB
      Protein Added: AAD15665.1     tbtM     multidrug efflux RND transporter outer membrane channel subunit TbtM
      Protein Added: AAD17509.1     f17a     F17A fimbrial adhesin
      Protein Added: AAD17510.1     f17a     F17A fimbrial adhesin
      Protein Added: AAD17511.1     f17a     F17A fimbrial adhesin
      Protein Added: AAD17513.1     f17g     F17G fimbrial adhesin
      Protein Added: AAD17514.1     f17g     F17G fimbrial adhesin
      Protein Added: AAD17515.1     f17g     F17G fimbrial adhesin
      Protein Added: AAA18786.1     cdtB     cytolethal distending toxin type II nuclease subunit CdtB
      Protein Added: CAA77320.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: CAA77324.1     merD     mercury resistance co-regulator MerD
      Protein Added: CAA77325.1     merE     broad-spectrum mercury transporter MerE
      Protein Added: CAA81047.1     mtrR     multidrug efflux system transcriptional repressor MtrR
      Protein Added: AAA74436.1     mexA     multidrug efflux RND transporter periplasmic adaptor subunit MexA
      Protein Added: AGC14252.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAS47019.1     nleC     type III secretion system effector zinc metalloprotease NleC
      Protein Added: AGC85979.1     iss      increased serum survival lipoprotein Iss
      Protein Added: CCG33322.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: AAS50165.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAO18187.2     sdeB     multidrug efflux RND transporter permease subunit SdeB
      Protein Added: AAA98221.1     merR     mercury resistance transcriptional regulator MerR
      Protein Added: AAS76847.1     fedA     F18 fimbrial major subunit FedA
      Protein Added: AAD25959.1     merR2    mercury resistance transcriptional regulator MerR2
      Protein Added: AAA98245.1     merA     mercury(II) reductase
      Protein Added: AAD27810.1     aafC     aggregative adherence fimbria II usher protein AafC
      Protein Added: AAA24698.1     tsh      temperature-sensitive protease autotransporter hemagglutinin Tsh
      Protein Added: CAE82650.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: CAE82653.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: CAE82670.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: AAD28079.1     hlyE     hemolysin HlyE
      Protein Added: CAA83535.1     aggR     aggregative adherence transcriptional regulator AggR
      Protein Added: EMS03085.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: CAE55775.1     auto-sat serine protease autotransporter toxin Sat
      Protein Added: AAT36311.1     rpeA     serine protease autotransporter colonization factor RpeA
      Protein Added: BAA77749.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: BAA77750.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: BAA77751.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAA46767.1     stx2Ab   Shiga toxin Stx2b subunit A
      Protein Added: CAA46768.1     stx2Bb   Shiga toxin Stx2b subunit B
      Protein Added: CAA77936.1     emrE     multidrug efflux SMR transporter EmrE
      Protein Added: AAT65972.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAT66000.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAT66010.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAT66011.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: AAT66012.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AGL46515.1     merF     mercury resistance system transport protein MerF
      Protein Added: AAT68784.1     subB     subtilase AB5 cytotoxin subunit B
      Protein Added: AAT68785.1     subA     subtilase AB5 cytotoxin subunit A
      Protein Added: AAT76975.1     lpfA     long polar fimbria major subunit LpfA-O113
      Protein Added: AAD39553.1     ttgA     toluene efflux RND transporter periplasmic adaptor subunit TtgA
      Protein Added: AAU01878.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: AAN38824.2     adeE     multidrug efflux RND transporter permease subunit AdeE
      Protein Added: AAU10477.1     adeD     multidrug efflux RND transporter periplasmic adaptor subunit AdeD
      Protein Added: AAU88208.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAU88264.1     cdtB     cytolethal distending toxin nuclease subunit CdtB
      Protein Added: AAA57451.1     aggD     aggregative adherence fimbria I chaperone AggD
      Protein Added: AAA57452.1     aggC     aggregative adherence fimbria I usher protein AggC
      Protein Added: AAA57453.1     aggB     aggregative adherence fimbria I minor subunit AggB
      Protein Added: AAA57454.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: CAA85366.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAA85368.1     stx1Aa   Shiga toxin Stx1a subunit A
      Protein Added: CAA85370.1     stx1Ac   Shiga toxin Stx1c subunit A
      Protein Added: CAA85371.1     stx1Bc   Shiga toxin Stx1c subunit B
      Protein Added: EQX61716.1     aggA     aggregative adherence fimbria I major subunit AggA
      Protein Added: AAU95470.1     nleB     type III secretion system effector arginine glycosyltransferase NleB
      Protein Added: AAU95768.1     mepA     multidrug efflux MATE transporter MepA
      Protein Added: CAG17536.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: CAG17541.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: AAD43578.1     astA     heat-stable enterotoxin EAST1
      Protein Added: AAD43579.1     astA     heat-stable enterotoxin EAST1
      Protein Added: CAA85780.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: AAA80193.1     mtrC     multidrug efflux RND transporter periplasmic adaptor subunit MtrC
      Protein Added: AAD44693.1     mtrA     efflux transporter MtrCDE transcriptional activator MtrA
      Protein Added: AAD47284.1     terZ     tellurium resistance-associated protein TerZ
      Protein Added: AAW38464.1     lmrS     multidrug efflux MFS transporter LmrS
      Protein Added: CAI43856.1     espF     type III secretion system LEE effector EspF
      Protein Added: CAI43860.1     espB     type III secretion system LEE translocon pore-forming subunit EspB
      Protein Added: CAI43862.1     espA     type III secretion system LEE translocon filament protein EspA
      Protein Added: CAI43865.1     eae      intimin type epsilon
      Protein Added: CAI43867.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAD54074.1     farB     fatty acid resistance MFS efflux transporter permease subunit FarB
      Protein Added: BAA84838.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: BAA84859.1     perA     BFP system transcriptional regulator PerA
      Protein Added: AAT35241.2     tsh      temperature-sensitive protease autotransporter hemagglutinin Tsh
      Protein Added: AAF03351.1     espF     type III secretion system LEE effector EspF
      Protein Added: AHW84565.1     aaiC     type VI secretion system protein AaiC/Hcp2
      Protein Added: AHW84567.1     aaiC     type VI secretion system protein AaiC/Hcp2
      Protein Added: AAX47728.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAX47729.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAX47730.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAX47731.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: CAA58525.1     pcoA     multicopper oxidase PcoA
      Protein Added: CAA58526.1     pcoB     copper-binding protein PcoB
      Protein Added: CAA58527.1     pcoC     copper resistance system metallochaperone PcoC
      Protein Added: CAA58528.1     pcoD     copper resistance inner membrane protein PcoD
      Protein Added: CAA58529.1     pcoR     copper response regulator transcription factor PcoR
      Protein Added: CAA58530.1     pcoS     copper resistance membrane spanning protein PcoS
      Protein Added: CAA58532.1     pcoE     copper resistance system metallochaperone PcoE
      Protein Added: AAX63244.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAX63245.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAX63259.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAX63270.1     fedF     F18 fimbrial adhesin subunit FedF
      Protein Added: AAY25390.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAY25394.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAY25395.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAF14522.1     mexX     multidrug efflux RND transporter periplasmic adaptor subunit MexX
      Protein Added: CAI91198.1     stx2Ag   Shiga toxin Stx2g subunit A
      Protein Added: AAF16681.1     srpS     solvent efflux transporter transcriptional repressor SrpS
      Protein Added: AAF16682.1     srpR     solvent efflux transporter antirepressor SrpR
      Protein Added: CAA54115.1     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: AAF23359.1     eae      intimin type epsilon
      Protein Added: CAB64953.1     stx2Af   Shiga toxin Stx2f subunit A
      Protein Added: AAY63864.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: AAY63865.1     stx2Bd   Shiga toxin Stx2d subunit B
      Protein Added: CDY80020.1     hsp20    small heat shock protein sHSP20
      Protein Added: AAY90615.1     emhC     efflux RND transporter outer membrane subunit EmhC
      Protein Added: KGL71342.1     silF     Ag(+)/Cu(+) efflux RND transporter periplasmic metallochaperone SilF
      Protein Added: AAF40764.1     farB     fatty acid resistance MFS efflux transporter permease subunit FarB
      Protein Added: AAF42063.1     mtrC     multidrug efflux RND transporter periplasmic adaptor subunit MtrC
      Protein Added: AAB26855.2     nfaE     Dr family non-fimbrial adhesin I chaperone NfaE
      Protein Added: CAB82448.1     cnrY     nickel resistance system anti-sigma factor CnrY
      Protein Added: AAZ76497.1     ehxA     enterohemolysin
      Protein Added: AAZ76514.1     espP     serine protease autotransporter EspP
      Protein Added: AAZ76524.1     subA     subtilase AB5 cytotoxin subunit A
      Protein Added: AAZ87985.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: AAZ88030.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: AAZ89804.1     sigA     serine protease autotransporter toxin SigA
      Protein Added: AAZ91108.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: ABA25986.1     merF     mercury resistance system transport protein MerF
      Protein Added: AAX22079.2     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: AAA65102.1     nccX     periplasmic metal sensor NccX
      Protein Added: AAA65103.1     nccH     nickel/cobalt/cadmium resistance ECF sigma factor NccH
      Protein Added: ABB16332.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: ABB36584.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: ABB36586.1     stx2Ad   Shiga toxin Stx2d subunit A
      Protein Added: ABB61187.1     iroN     siderophore salmochelin receptor IroN
      Protein Added: ABB62096.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABB62098.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABB64677.1     ipaD     type III secretion system needle tip complex protein IpaD
      Protein Added: ABB65884.1     ipaH3    T3SS effector E3 ubiquitin-protein ligase IpaH3
      Protein Added: ABB66229.1     ipaH9.8  T3SS effector E3 ubiquitin-protein ligase IpaH9.8
      Protein Added: ABB68924.1     virF     AraC family invasion system transcriptional regulator VirF
      Protein Added: KLB41245.1     copL     transcriptional regulator CopL
      Protein Added: CAI79539.1     eatA     serine protease autotransporter toxin EatA
      Protein Added: CAJ44959.1     mchF     microcin H47 export transporter peptidase/ATP-binding subunit MchF
      Protein Added: CAB77169.2     stx2Ae   Shiga toxin Stx2e subunit A
      Protein Added: CAB94149.1     stx2Ba   Shiga toxin Stx2a subunit B
      Protein Added: AAC34727.1     faeG     F4 fimbrial adhesin subunit FaeG
      Protein Added: BAA96815.1     tir      type III secretion system LEE translocated intimin receptor Tir
      Protein Added: AAA69514.1     f17g     F17G fimbrial adhesin
      Protein Added: CAA88252.1     sepA     serine protease autotransporter toxin SepA
      Protein Added: BAE79899.1     smfY     multidrug efflux MFS transporter SmfY
      Protein Added: ABE06598.1     sfaS     S-fimbrial adhesin minor subunit SfaS
      Protein Added: ABE10324.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: CAJ34994.1     bfpA     bundle-forming pilus major subunit BfpA
      Protein Added: ABF13034.1     merD     mercury resistance co-regulator MerD
      Protein Added: ABF13067.1     cnrC     nickel efflux RND transporter outer membrane subunit CnrC
      Protein Added: ABF13069.1     cnrA     nickel efflux RND transporter permease subunit CnrA
      Protein Added: ABF13070.1     cnrT     nickel diffusion facilitator CnrT
      Protein Added: ABF14406.1     ncrA     Metal Resistance
      Protein Added: ABF14407.1     ncrB     nickel-sensing transcriptional repressor NcrB
      Protein Added: CAK02719.1     cnf1     cytotoxic necrotizing factor CNF1
      Protein Added: CAA90630.1     stx2Aa   Shiga toxin Stx2a subunit A
      Protein Added: BAT41861.1     eae      intimin type alpha
      Protein Added: CAK15125.1     mexE     MexE family multidrug efflux RND transporter periplasmic adaptor subunit
      Protein Added: AAG01033.1     stx2Ac   Shiga toxin Stx2c subunit A
      Protein Added: AAB59153.1     cadC     Cd(II)/Pb(II)/Zn(II)-sensing metalloregulatory transcriptional repressor CadC
      Protein Added: ABF61434.1     ncrA     Metal Resistance
      Protein Added: ABF61435.1     ncrB     nickel-sensing transcriptional repressor NcrB
      Protein Added: ABF61437.1     ncrY     nickel resistance OB fold protein NcrY
      Protein Added: AAG05881.1     mexE     MexE family multidrug efflux RND transporter periplasmic adaptor subunit
      Protein Added: AAG10695.1     perA     BFP system transcriptional regulator PerA
      Protein Added: WP_000697899.1 pmrA     pmrA
      Protein Added: WP_097509477.1 acrB     acrB

- AMRFinder HMM library Changes:
      Prev. Release:   574
       This Release:   610
            Removed:     2
              Added:    38
            Changed:   572
        HMM Removed:  NF000478.2      linco_LnuE
        HMM Removed:  NF012180.1      tet_MFS_43
          HMM Added:  NF000131.1      MATE_multi_MepA
          HMM Added:  NF000249.1      MexE
          HMM Added:  NF000252.1      MexX
          HMM Added:  NF000263.1      MATE_multi_NorM
          HMM Added:  NF000282.2      RND_permease_1
          HMM Added:  NF000314.1      adeB
          HMM Added:  NF000315.1      adeC-adeK-oprM
          HMM Added:  NF000336.1      emrE
          HMM Added:  NF007842.1      PRK10555.1
          HMM Added:  NF010310.2      PRK13747.1
          HMM Added:  NF010315.0      PRK13752.1
          HMM Added:  NF011706.2      PRK15127.1
          HMM Added:  NF028537.1      P_eth_NH2_trans
          HMM Added:  NF033086.2      penta_rpt_Qnr
          HMM Added:  NF033134.0      cmlA_floR
          HMM Added:  NF033142.1      efflux_OM_AdeC
          HMM Added:  NF033143.1      efflux_OM_AdeK
          HMM Added:  NF033555.1      lyase_MerB
          HMM Added:  NF033560.1      merT_RC607
          HMM Added:  NF033565.0      trans_MerF
          HMM Added:  NF033627.3      intimin_all
          HMM Added:  NF033637.1      transloc_TIR
          HMM Added:  NF033639.1      intimin_alpha
          HMM Added:  NF033643.1      EspJ_gen
          HMM Added:  NF033646.1      toxin_EAST1
          HMM Added:  NF033651.1      cyto_nec_fctrs
          HMM Added:  NF033658.1      Shiga_Stx1A
          HMM Added:  NF033659.0      Shiga_Stx1B
          HMM Added:  NF033660.0      Shiga_Stx2B
          HMM Added:  NF033661.1      Shiga_Stx2A
          HMM Added:  NF033727.1      chaperon_ArsD
          HMM Added:  NF033781.1      chaper_CopP
          HMM Added:  NF033783.1      coreg_MerD
          HMM Added:  NF033784.1      transport_merC
          HMM Added:  NF033786.1      phenyl_MerG
          HMM Added:  NF033834.1      RND_adapt_MexA
          HMM Added:  TIGR02052.1     TIGR02052
          HMM Added:  TIGR02053.1     TIGR02053
---------------------------------------------------------------------
Changes included in 2019-04-29.1
---------------------------------------------------------------------

Summary: In addition to the usual addition of 134 new genes and alleles
community feedback led to the renaming of a few dfr genes.  The family
heirarchy file (fam.tab) was cleaned up by removing a number of superfluous
entries.

Changes included in 2019-04-29.1
- Protein changes:
      Prev. Release:  4810
       This Release:  4942
            Removed:     1
              Added:   134
           Modified:     3
        Protein Removed:  WP_109545040.1  chrB
          Protein Added:  WP_000054744.1  satA_Ba
          Protein Added:  WP_001211209.1  blaADC-140
          Protein Added:  WP_001211210.1  blaADC-185
          Protein Added:  WP_001211214.1  blaADC-144
          Protein Added:  WP_001211215.1  blaADC-115
          Protein Added:  WP_001572373.1  mcr-9.1
          Protein Added:  WP_002126587.1  blaADC-120
          Protein Added:  WP_002157727.1  blaADC-117
          Protein Added:  WP_003112187.1  blaADC-191
          Protein Added:  WP_003242546.1  satA_Bs
          Protein Added:  WP_004643536.1  blaADC-128
          Protein Added:  WP_004700205.1  blaADC-133
          Protein Added:  WP_004707701.1  blaADC-131
          Protein Added:  WP_004712857.1  blaADC-119
          Protein Added:  WP_004790939.1  blaADC-135
          Protein Added:  WP_004840559.1  blaADC-123
          Protein Added:  WP_004886093.1  blaADC-130
          Protein Added:  WP_005039111.1  blaADC-129
          Protein Added:  WP_005046018.1  blaADC-127
          Protein Added:  WP_005068074.1  blaADC-132
          Protein Added:  WP_005109685.1  blaADC-121
          Protein Added:  WP_005123276.1  blaADC-122
          Protein Added:  WP_005131186.1  blaADC-125
          Protein Added:  WP_005307218.1  blaADC-134
          Protein Added:  WP_005404206.1  blaOXA-813
          Protein Added:  WP_005405613.1  blaOXA-814
          Protein Added:  WP_013197184.1  blaADC-193
          Protein Added:  WP_014207272.1  blaADC-149
          Protein Added:  WP_016137488.1  blaADC-136
          Protein Added:  WP_016140427.1  blaADC-137
          Protein Added:  WP_016146025.1  blaADC-138
          Protein Added:  WP_017386568.1  blaADC-150
          Protein Added:  WP_017778762.1  mcr-3.27
          Protein Added:  WP_017816757.1  blaADC-116
          Protein Added:  WP_026382828.1  blaOXA-114i
          Protein Added:  WP_026444036.1  blaOXA-816
          Protein Added:  WP_032039838.1  blaADC-139
          Protein Added:  WP_032053762.1  blaOXA-819
          Protein Added:  WP_032057042.1  blaOXA-820
          Protein Added:  WP_032062810.1  blaADC-141
          Protein Added:  WP_032625176.1  blaACT-66
          Protein Added:  WP_033502167.1  blaADC-143
          Protein Added:  WP_034670108.1  blaOXA-818
          Protein Added:  WP_034688190.1  blaOXA-812
          Protein Added:  WP_036299413.1  sulR
          Protein Added:  WP_039246976.1  blaADC-148
          Protein Added:  WP_039258389.1  blaADC-146
          Protein Added:  WP_039270258.1  blaADC-145
          Protein Added:  WP_044718369.1  blaADC-147
          Protein Added:  WP_047726486.1  blaACT-65
          Protein Added:  WP_053498400.1  blaOXA-114h
          Protein Added:  WP_054437016.1  blaOXA-114j
          Protein Added:  WP_054471662.1  blaOXA-114m
          Protein Added:  WP_054500785.1  blaOXA-789
          Protein Added:  WP_054517040.1  blaOXA-114l
          Protein Added:  WP_057061999.1  blaOXA-821
          Protein Added:  WP_059247009.1  blaADC-184
          Protein Added:  WP_063099318.1  blaADC-151
          Protein Added:  WP_063147148.1  blaACT-67
          Protein Added:  WP_072292271.1  blaADC-186
          Protein Added:  WP_075040046.1  blaOXA-817
          Protein Added:  WP_076412384.1  blaOXA-114p
          Protein Added:  WP_099595307.1  dfrA35
          Protein Added:  WP_103663397.1  sulX
          Protein Added:  WP_106743337.1  mcr-1.18
          Protein Added:  WP_109545052.1  mcr-1.14
          Protein Added:  WP_110612827.1  blaOXA-796
          Protein Added:  WP_111280830.1  blaOXA-815
          Protein Added:  WP_115470049.1  blaKPC-40
          Protein Added:  WP_117664257.1  cfxA6
          Protein Added:  WP_125052776.1  blaADC-114
          Protein Added:  WP_136512051.1  blaACT-68
          Protein Added:  WP_136512052.1  blaADC-109
          Protein Added:  WP_136512053.1  blaADC-110
          Protein Added:  WP_136512054.1  blaADC-112
          Protein Added:  WP_136512055.1  blaADC-113
          Protein Added:  WP_136512056.1  blaADC-187
          Protein Added:  WP_136512057.1  blaADC-188
          Protein Added:  WP_136512058.1  blaADC-189
          Protein Added:  WP_136512059.1  blaADC-190
          Protein Added:  WP_136512060.1  blaADC-192
          Protein Added:  WP_136512061.1  blaADC-24
          Protein Added:  WP_136512062.1  blaADC-65
          Protein Added:  WP_136512063.1  blaADC-66
          Protein Added:  WP_136512064.1  blaCTX-M-225
          Protein Added:  WP_136512065.1  blaCTX-M-226
          Protein Added:  WP_136512066.1  blaFRI-7
          Protein Added:  WP_136512067.1  blaIMI-18
          Protein Added:  WP_136512068.1  blaIMP-39
          Protein Added:  WP_136512069.1  blaIMP-46
          Protein Added:  WP_136512070.1  blaKPC-42
          Protein Added:  WP_136512071.1  blaKPC-43
          Protein Added:  WP_136512072.1  blaNDM-28
          Protein Added:  WP_136512073.1  blaOXA-114k
          Protein Added:  WP_136512074.1  blaOXA-114n
          Protein Added:  WP_136512075.1  blaOXA-114q
          Protein Added:  WP_136512076.1  blaOXA-114r
          Protein Added:  WP_136512077.1  blaOXA-114s
          Protein Added:  WP_136512078.1  blaOXA-114t
          Protein Added:  WP_136512079.1  blaOXA-114u
          Protein Added:  WP_136512080.1  blaOXA-114v
          Protein Added:  WP_136512081.1  blaOXA-114w
          Protein Added:  WP_136512082.1  blaOXA-114x
          Protein Added:  WP_136512083.1  blaOXA-787
          Protein Added:  WP_136512084.1  blaOXA-788
          Protein Added:  WP_136512085.1  blaOXA-793
          Protein Added:  WP_136512086.1  blaOXA-794
          Protein Added:  WP_136512087.1  blaOXA-795
          Protein Added:  WP_136512088.1  blaOXA-797
          Protein Added:  WP_136512089.1  blaOXA-798
          Protein Added:  WP_136512090.1  blaOXA-799
          Protein Added:  WP_136512091.1  blaOXA-800
          Protein Added:  WP_136512092.1  blaOXA-801
          Protein Added:  WP_136512093.1  blaOXA-802
          Protein Added:  WP_136512094.1  blaOXA-803
          Protein Added:  WP_136512095.1  blaOXA-804
          Protein Added:  WP_136512096.1  blaOXA-805
          Protein Added:  WP_136512097.1  blaOXA-806
          Protein Added:  WP_136512098.1  blaOXA-807
          Protein Added:  WP_136512099.1  blaOXA-808
          Protein Added:  WP_136512100.1  blaOXA-809
          Protein Added:  WP_136512101.1  blaOXA-810
          Protein Added:  WP_136512102.1  blaOXA-811
          Protein Added:  WP_136512103.1  blaOXA-823
          Protein Added:  WP_136512104.1  blaOXA-824
          Protein Added:  WP_136512105.1  blaPER-13
          Protein Added:  WP_136512106.1  blaVIM-48
          Protein Added:  WP_136512107.1  blaVIM-55
          Protein Added:  WP_136512108.1  blaVIM-63
          Protein Added:  WP_136512109.1  blaVIM-66
          Protein Added:  WP_136512110.1  mcr-1.16
          Protein Added:  WP_136512111.1  mcr-1.17
          Protein Added:  WP_136512112.1  mcr-3.29
       Protein Modified:  WP_001031075.1 dfr18 updated to WP_001031075.1 dfrA18
       Protein Modified:  WP_032490189.1 dfrA18 updated to WP_032490189.1 dfrA19
       Protein Modified:  WP_063843245.1 chrB updated to WP_063843245.1 chrB_rRNA_meth
- AMR HMM library Changes:
      Prev. Release:   571
       This Release:   574
            Removed:     0
              Added:     3
            Changed:   571
              HMM Added:  NF033818.0      blaOXA-114_like
              HMM Added:  NF033836.1      polymyxin_MCR9
              HMM Added:  NF033851.1      trim_DfrA35
           HMM Modified:  NF000039.1 trim_Dfr18 renamed to NF000039.1 trim_DfrA18
           HMM Modified:  NF000041.1 trim_DfrA18_A19 renamed to NF000041.1 trim_DfrA19
           HMM Modified:  NF000422.2 blaPDC updated to NF000422.6 blaPDC
- Protein family changes:
      Prev. Release:  1177
       This Release:  1119
            Removed:    68
              Added:    10
           Modified:     4
         Family Removed:  -               PORIN
         Family Removed:  -               aac(1)
         Family Removed:  -               aac(3')-IIe
         Family Removed:  -               aac(3)-Ie
         Family Removed:  -               aac(3)-VI
         Family Removed:  -               aac(3)-Vb
         Family Removed:  -               aac(6')-Ib8
         Family Removed:  -               aacA44
         Family Removed:  -               aadA1bt
         Family Removed:  -               aadA1r
         Family Removed:  -               aadA24
         Family Removed:  -               ampC_Eae
         Family Removed:  -               ampH
         Family Removed:  -               ampS
         Family Removed:  -               ant(3'')(9)
         Family Removed:  -               ant(3'')-Ii
         Family Removed:  -               aph(3')-Ic
         Family Removed:  -               arr-Cb
         Family Removed:  -               blaCMG
         Family Removed:  -               blaKLUG
         Family Removed:  -               blaLMB
         Family Removed:  -               blaMSI-OXA
         Family Removed:  -               blaOXA_missing
         Family Removed:  -               blaPNGM
         Family Removed:  -               blaZEG
         Family Removed:  -               blmS
         Family Removed:  -               catA12
         Family Removed:  -               ccrA
         Family Removed:  NF000488.1      chrB
         Family Removed:  -               cml
         Family Removed:  -               cmlA7
         Family Removed:  -               cmlA9
         Family Removed:  NF000039.1      dfr18
         Family Removed:  NF000041.1      dfrA18_dfrA19
         Family Removed:  -               dfrA1_var
         Family Removed:  -               dfrA29
         Family Removed:  -               dfrA33
         Family Removed:  -               dfrB7
         Family Removed:  -               flo
         Family Removed:  -               mef(E)
         Family Removed:  -               mef(G)
         Family Removed:  -               mef(I)
         Family Removed:  -               mph(D)
         Family Removed:  -               nimF
         Family Removed:  -               nimH
         Family Removed:  -               omp35
         Family Removed:  -               ompE35
         Family Removed:  -               otr(C)
         Family Removed:  -               penA
         Family Removed:  -               sat2A
         Family Removed:  -               sat3A
         Family Removed:  -               spc
         Family Removed:  -               sul1delta
         Family Removed:  -               vanH-Ac2
         Family Removed:  -               vanH-F
         Family Removed:  -               vanR-Pt
         Family Removed:  -               vanR-Pt2
         Family Removed:  -               vanS-I
         Family Removed:  -               vanSc
         Family Removed:  -               vanTc4
         Family Removed:  -               vanX-Ac2
         Family Removed:  -               vanX-F
         Family Removed:  -               vanX-Pt2
         Family Removed:  -               vanY-40021673
         Family Removed:  -               vanY-D4
         Family Removed:  -               vanY-D5
         Family Removed:  -               vanY-M
         Family Removed:  -               vanY-Pt2
           Family Added:  NF033818.0      blaOXA-114_like
           Family Added:  NF033851.1      dfrA35
           Family Added:  NF033124.1      estX
           Family Added:  NF033836.1      mcr-9
           Family Added:  -               satA_Bs
           Family Added:  -               sulR
           Family Added:  -               sulX
         Family Changed:  NF000422.2 blaPDC updated to NF000422.6 blaPDC
         Family Changed:  NF000488.1 chrB renamed to chrB_rRNA_meth
         Family Changed:  NF000039.1 dfr18 renamed to dfrA18
         Family Changed:  NF000041.1 dfrA18_dfrA19 renamed to dfrA19
---------------------------------------------------------------------
Changes included in 2019-02-08.1
---------------------------------------------------------------------

Two incorrectly assigned proteins were accidentally released. They are not
AMR proteins and should not have been released. This release simply removes
them and is otherwise unchanged.

- Protein changes:
      Prev. Release:  4812
       This Release:  4810
            Removed:     2
              Added:     0
            Changed:  4810
        Protein Removed:  WP_000122253.1  sat
        Protein Removed:  WP_001045652.1  sat
---------------------------------------------------------------------
Changes included in 2019-02-04.1
---------------------------------------------------------------------
- Protein name changes:
    "inhibitor-resistant" was added to the names of:
    blaKPC-8
    blaKPC-30
    blaKPC-31
    blaKPC-32
    blaKPC-33
- Protein changes:
      Prev. Release:  4730
       This Release:  4812
            Removed:     0
              Added:    82
       Protein modified:  WP_063855700.1  tet(35) replaced with WP_005480402.1
          Protein Added:  WP_000122253.1  sat
          Protein Added:  WP_001045652.1  sat
          Protein Added:  WP_002415638.1  poxtA
          Protein Added:  WP_003234144.1  vmlR
          Protein Added:  WP_029728367.1  blaB
          Protein Added:  WP_044103626.1  blaVEB-21
          Protein Added:  WP_046693238.1  blaADC-181
          Protein Added:  WP_049637206.1  blaOXA-780
          Protein Added:  WP_057691114.1  blaADC-182
          Protein Added:  WP_058492019.1  vanI
          Protein Added:  WP_065980086.1  blaOXA-784
          Protein Added:  WP_069953510.1  blaAFM-1
          Protein Added:  WP_069996660.1  mecC3
          Protein Added:  WP_071223118.1  taeA
          Protein Added:  WP_087343787.1  ant(6)-Ic
          Protein Added:  WP_087344360.1  blaBBI
          Protein Added:  WP_087344902.1  catV
          Protein Added:  WP_087346196.1  ant(4')-Ic
          Protein Added:  WP_087347987.1  rphC
          Protein Added:  WP_087348261.1  rphD
          Protein Added:  WP_087349244.1  mphJ
          Protein Added:  WP_087349651.1  aac(6')-35
          Protein Added:  WP_114225343.1  blaOXA-739
          Protein Added:  WP_123002100.1  blaGES-40
          Protein Added:  WP_123002101.1  blaKPC-38
          Protein Added:  WP_123002102.1  blaNDM-27
          Protein Added:  WP_123002103.1  blaVIM-61
          Protein Added:  WP_126205827.1  blaOXA-785
          Protein Added:  WP_127728991.1  blaFRI-6
          Protein Added:  WP_128268231.1  mecC2
          Protein Added:  WP_128268232.1  blaADC-183
          Protein Added:  WP_128268233.1  blaCARB-50
          Protein Added:  WP_128268234.1  blaCFE-2
          Protein Added:  WP_128268235.1  blaCTX-M-215
          Protein Added:  WP_128268236.1  blaDHA-28
          Protein Added:  WP_128268237.1  blaKPC-39
          Protein Added:  WP_128268238.1  blaOXA-738
          Protein Added:  WP_128268239.1  blaOXA-740
          Protein Added:  WP_128268240.1  blaOXA-741
          Protein Added:  WP_128268241.1  blaOXA-742
          Protein Added:  WP_128268242.1  blaOXA-743
          Protein Added:  WP_128268243.1  blaOXA-744
          Protein Added:  WP_128268244.1  blaOXA-745
          Protein Added:  WP_128268245.1  blaOXA-746
          Protein Added:  WP_128268246.1  blaOXA-747
          Protein Added:  WP_128268247.1  blaOXA-748
          Protein Added:  WP_128268248.1  blaOXA-749
          Protein Added:  WP_128268249.1  blaOXA-750
          Protein Added:  WP_128268250.1  blaOXA-751
          Protein Added:  WP_128268251.1  blaOXA-752
          Protein Added:  WP_128268252.1  blaOXA-753
          Protein Added:  WP_128268253.1  blaOXA-754
          Protein Added:  WP_128268254.1  blaOXA-755
          Protein Added:  WP_128268255.1  blaOXA-756
          Protein Added:  WP_128268256.1  blaOXA-757
          Protein Added:  WP_128268257.1  blaOXA-758
          Protein Added:  WP_128268258.1  blaOXA-759
          Protein Added:  WP_128268259.1  blaOXA-760
          Protein Added:  WP_128268260.1  blaOXA-761
          Protein Added:  WP_128268261.1  blaOXA-762
          Protein Added:  WP_128268262.1  blaOXA-763
          Protein Added:  WP_128268263.1  blaOXA-764
          Protein Added:  WP_128268264.1  blaOXA-765
          Protein Added:  WP_128268265.1  blaOXA-766
          Protein Added:  WP_128268266.1  blaOXA-767
          Protein Added:  WP_128268267.1  blaOXA-768
          Protein Added:  WP_128268268.1  blaOXA-769
          Protein Added:  WP_128268269.1  blaOXA-770
          Protein Added:  WP_128268270.1  blaOXA-771
          Protein Added:  WP_128268271.1  blaOXA-772
          Protein Added:  WP_128268272.1  blaOXA-773
          Protein Added:  WP_128268273.1  blaOXA-774
          Protein Added:  WP_128268274.1  blaOXA-775
          Protein Added:  WP_128268275.1  blaOXA-776
          Protein Added:  WP_128268276.1  blaOXA-781
          Protein Added:  WP_128268277.1  blaOXA-782
          Protein Added:  WP_128268278.1  blaOXA-783
          Protein Added:  WP_128268279.1  blaOXA-786
          Protein Added:  WP_128268280.1  blaPDC-317
          Protein Added:  WP_128268286.1  blaVEB-20
          Protein Added:  WP_128268287.1  blaVIM-62
          Protein Added:  WP_128268288.1  qnrS15
- AMR HMM library Changes:
      Prev. Release:   568
       This Release:   571
            Removed:     0
              Added:     3
              HMM Added:  NF033714.1      blaBBI
              HMM Added:  NF033736.1      blaAFM
              HMM Added:  NF033815.0      blaOXA-364_like
           HMM Modified:  NF000355.2 ribo_prot_ABC_F updated to NF000355.3 ribo_prot_ABC_F
- Protein family changes:
      Prev. Release:  1161
       This Release:  1177
            Removed:     0
              Added:    16
           Family Added:  -               aac(6')-35
           Family Added:  -               ant(4')-Ic
           Family Added:  -               ant(6)-Ic
           Family Added:  NF033736.1      blaAFM
           Family Added:  NF033714.1      blaBBI
           Family Added:  NF033815.0      blaOXA-364_like
           Family Added:  -               mecC2
           Family Added:  -               mecC3
           Family Added:  -               mphJ
           Family Added:  -               poxtA
           Family Added:  -               rphC
           Family Added:  -               rphD
           Family Added:  -               rph_gen
           Family Added:  -               satA_Ba
           Family Added:  -               taeA
           Family Added:  -               vmlR
         Family Changed:  NF000355.2 abc-f updated to NF000355.3 abc-f

---------------------------------------------------------------------
Changes included in 2018-11-07.1
---------------------------------------------------------------------

Due to a communication error three blaOXA alleles in the AMR database have
been reassigned. Alleles published by Tian, et al. (PMID:30247543) have
replaced them.

AFY12006.1 JX846494.1 WP_072678505.1 NG_061615.1 were blaOXA-669, now they are blaOXA-732
AAL47570.1 AY066004.1 WP_114699266.1 NG_061383.1 were blaOXA-666, now they are blaOXA-729
AXH06203.1 MH684781.1 WP_116786836.1 NG_061623.1 were blaOXA-667, now they are blaOXA-730

- Protein changes:
      Prev. Release:  4579
       This Release:  4730
            Removed:     0
              Added:   151
          Protein Added:  WP_004143591.1  blaSHV-206
          Protein Added:  WP_004384957.1  blaCSA-2
          Protein Added:  WP_007888761.1  blaCSA-1
          Protein Added:  WP_011245929.1  clbB
          Protein Added:  WP_011707905.1  blaOXA-725
          Protein Added:  WP_012116915.1  clbA
          Protein Added:  WP_015892743.1  clbC
          Protein Added:  WP_016162389.1  blaOXA-673
          Protein Added:  WP_016168805.1  blaOXA-664
          Protein Added:  WP_016651348.1  blaOXA-670
          Protein Added:  WP_016657654.1  blaOXA-665
          Protein Added:  WP_016660101.1  blaOXA-671
          Protein Added:  WP_016685888.1  blaOXA-715
          Protein Added:  WP_017822040.1  qnrVC10
          Protein Added:  WP_023271137.1  blaOXA-672
          Protein Added:  WP_023341517.1  blaSHV-211
          Protein Added:  WP_031998610.1  blaOXA-716
          Protein Added:  WP_032018141.1  blaOXA-717
          Protein Added:  WP_032495491.1  blaKLUC-3
          Protein Added:  WP_032495492.1  blaKLUC-4
          Protein Added:  WP_032974004.1  blaCMA-1
          Protein Added:  WP_033179079.1  crpP
          Protein Added:  WP_034612711.1  blaOXA-668
          Protein Added:  WP_056517622.1  blaOXA-669
          Protein Added:  WP_057097547.1  aph(2'')-If2
          Protein Added:  WP_058652112.1  dfrA34
          Protein Added:  WP_064733493.1  blaSHV-207
          Protein Added:  WP_064760451.1  qepA4
          Protein Added:  WP_064768701.1  qepA7
          Protein Added:  WP_077096319.1  blaOXA-724
          Protein Added:  WP_081406929.1  blaOXA-674
          Protein Added:  WP_081853183.1  blaELM-1
          Protein Added:  WP_092689909.1  blaOXA-666
          Protein Added:  WP_094166899.1  blaCTX-M-224
          Protein Added:  WP_096735335.1  blaOXA-667
          Protein Added:  WP_096941464.1  qepA6
          Protein Added:  WP_100663667.1  blaKLUC-5
          Protein Added:  WP_101150415.1  blaOXA-726
          Protein Added:  WP_104159136.1  blaSHV-224
          Protein Added:  WP_105620838.1  blaCMA-2
          Protein Added:  WP_109232473.1  blaSHV-220
          Protein Added:  WP_109638756.1  qepA8
          Protein Added:  WP_112021705.1  qepA9
          Protein Added:  WP_113334341.1  qepA10
          Protein Added:  WP_115196748.1  blaSHV-210
          Protein Added:  WP_117241614.1  blaSHV-223
          Protein Added:  WP_122630822.1  blaEFM-1
          Protein Added:  WP_122630823.1  blaEVM-1
          Protein Added:  WP_122630824.1  blaECM-1
          Protein Added:  WP_122630825.1  blaEAM-1
          Protein Added:  WP_122630826.1  blaGES-38
          Protein Added:  WP_122630827.1  blaGES-39
          Protein Added:  WP_122630828.1  blaVIM-53
          Protein Added:  WP_122630829.1  blaDHT2-1
          Protein Added:  WP_122630830.1  blaSPN79-1
          Protein Added:  WP_122630831.1  blaCRD3-1
          Protein Added:  WP_122630832.1  blaALG6-1
          Protein Added:  WP_122630833.1  blaALG11-1
          Protein Added:  WP_122630834.1  blaGRD33-1
          Protein Added:  WP_122630835.1  blaGRD23-1
          Protein Added:  WP_122630836.1  blaCMY-158
          Protein Added:  WP_122630837.1  blaCMY-159
          Protein Added:  WP_122630838.1  blaSHV-201
          Protein Added:  WP_122630839.1  blaSHV-202
          Protein Added:  WP_122630840.1  aph(2'')
          Protein Added:  WP_122630841.1  blaTEM-237
          Protein Added:  WP_122630842.1  blaOXA-655
          Protein Added:  WP_122630843.1  blaOXA-656
          Protein Added:  WP_122630844.1  blaOXA-733
          Protein Added:  WP_122630845.1  blaPDC-307
          Protein Added:  WP_122630846.1  blaPDC-308
          Protein Added:  WP_122630847.1  blaPDC-309
          Protein Added:  WP_122630848.1  blaPDC-310
          Protein Added:  WP_122630849.1  blaPDC-311
          Protein Added:  WP_122630850.1  blaPDC-312
          Protein Added:  WP_122630851.1  blaPDC-313
          Protein Added:  WP_122630852.1  blaPDC-314
          Protein Added:  WP_122630853.1  blaOXA-734
          Protein Added:  WP_122630854.1  blaOXA-735
          Protein Added:  WP_122630855.1  blaOXA-736
          Protein Added:  WP_122630856.1  blaOXA-737
          Protein Added:  WP_122630857.1  blaOXA-675
          Protein Added:  WP_122630858.1  blaOXA-676
          Protein Added:  WP_122630859.1  blaOXA-677
          Protein Added:  WP_122630860.1  blaOXA-678
          Protein Added:  WP_122630861.1  blaIMP-80
          Protein Added:  WP_122630862.1  blaCTX-M-223
          Protein Added:  WP_122630863.1  blaSHV-205
          Protein Added:  WP_122630864.1  blaOXA-680
          Protein Added:  WP_122630865.1  blaSHV-208
          Protein Added:  WP_122630866.1  blaSHV-209
          Protein Added:  WP_122630867.1  blaSHV-212
          Protein Added:  WP_122630868.1  blaSHV-213
          Protein Added:  WP_122630869.1  blaSHV-214
          Protein Added:  WP_122630870.1  blaSHV-215
          Protein Added:  WP_122630871.1  blaSHV-216
          Protein Added:  WP_122630872.1  blaSHV-217
          Protein Added:  WP_122630873.1  blaSHV-218
          Protein Added:  WP_122630874.1  blaSHV-219
          Protein Added:  WP_122630875.1  blaSHV-221
          Protein Added:  WP_122630876.1  blaSHV-222
          Protein Added:  WP_122630877.1  blaSHV-225
          Protein Added:  WP_122630878.1  blaSHV-226
          Protein Added:  WP_122630879.1  blaSHV-227
          Protein Added:  WP_122630880.1  blaSHV-228
          Protein Added:  WP_122630881.1  blaOXA-681
          Protein Added:  WP_122630882.1  blaPDC-315
          Protein Added:  WP_122630883.1  blaPDC-316
          Protein Added:  WP_122630884.1  blaOXA-682
          Protein Added:  WP_122630885.1  blaOXA-683
          Protein Added:  WP_122630886.1  blaOXA-684
          Protein Added:  WP_122630887.1  blaOXA-685
          Protein Added:  WP_122630888.1  blaOXA-686
          Protein Added:  WP_122630889.1  blaOXA-687
          Protein Added:  WP_122630890.1  blaOXA-688
          Protein Added:  WP_122630891.1  blaOXA-689
          Protein Added:  WP_122630892.1  blaOXA-690
          Protein Added:  WP_122630893.1  blaOXA-691
          Protein Added:  WP_122630894.1  blaOXA-692
          Protein Added:  WP_122630895.1  blaOXA-693
          Protein Added:  WP_122630896.1  blaOXA-694
          Protein Added:  WP_122630897.1  blaOXA-695
          Protein Added:  WP_122630898.1  blaOXA-696
          Protein Added:  WP_122630899.1  blaOXA-697
          Protein Added:  WP_122630900.1  blaOXA-698
          Protein Added:  WP_122630901.1  blaOXA-699
          Protein Added:  WP_122630902.1  blaOXA-700
          Protein Added:  WP_122630903.1  blaOXA-701
          Protein Added:  WP_122630904.1  blaOXA-702
          Protein Added:  WP_122630905.1  blaOXA-703
          Protein Added:  WP_122630906.1  blaOXA-704
          Protein Added:  WP_122630907.1  blaOXA-705
          Protein Added:  WP_122630908.1  blaOXA-706
          Protein Added:  WP_122630909.1  blaOXA-707
          Protein Added:  WP_122630910.1  blaOXA-718
          Protein Added:  WP_122630911.1  blaOXA-719
          Protein Added:  WP_122630912.1  blaOXA-720
          Protein Added:  WP_122630913.1  blaOXA-721
          Protein Added:  WP_122630914.1  blaOXA-722
          Protein Added:  WP_122630915.1  blaOXA-723
          Protein Added:  WP_122630916.1  blaOXA-708
          Protein Added:  WP_122630917.1  blaOXA-709
          Protein Added:  WP_122630918.1  blaOXA-710
          Protein Added:  WP_122630919.1  blaOXA-711
          Protein Added:  WP_122630920.1  blaOXA-712
          Protein Added:  WP_122630921.1  blaOXA-713
          Protein Added:  WP_122630922.1  blaOXA-714
          Protein Added:  WP_122630923.1  blaOXA-777
          Protein Added:  WP_122630924.1  blaOXA-778
          Protein Added:  WP_122634438.1  blaOXA-779
          Protein Added:  WP_122634439.1  blaOXA-679
   Gene Symbol Modified:  WP_010890145.1 qacE_gen updated to WP_010890145.1 qacE
   Gene Symbol Modified:  WP_053515552.1 qacE_gen updated to WP_053515552.1 qacE
   Gene Symbol Modified:  WP_063844281.1 cphA updated to WP_063844281.1 cphA3
   Gene Symbol Modified:  WP_063854778.1 qepA updated to WP_063854778.1 qepA5
   Gene Symbol Modified:  WP_072678505.1 blaOXA-669 updated to WP_072678505.1 blaOXA-732
   Gene Symbol Modified:  WP_114699266.1 blaOXA-666 updated to WP_114699266.1 blaOXA-729
   Gene Symbol Modified:  WP_116786836.1 blaOXA-667 updated to WP_116786836.1 blaOXA-730
- AMR HMM library Changes:
      Prev. Release:   563
       This Release:   568
            Removed:     0
              Added:     5
              HMM Added:  NF033692.1      APH_2pp_I_a_f_h
              HMM Added:  NF033693.0      AAC_6p_Ie_fam
              HMM Added:  NF033698.1      blaCSA
              HMM Added:  NF033700.1      blaCMA
              HMM Added:  NF033702.0      blaOXA-12_like
      HMM Name Modified:  NF033666.1 blaOXA-664_like updated to NF033666.1 blaOXA-727_like
- Protein family changes:
      Prev. Release:  1133
       This Release:  1161
            Removed:     0
              Added:    28
           Family Added:  -               aac(6')-Ie2
           Family Added:  NF033693.0      aac(6')-Ie_fam
           Family Added:  NF011706.2      acrB
           Family Added:  NF007842.1      acrD
           Family Added:  NF000314.1      adeB/adeJ
           Family Added:  NF033692.1      aph(2'')-I_a_f_h
           Family Added:  -               aph(2'')-If2
           Family Added:  -               blaALG11
           Family Added:  -               blaALG6
           Family Added:  NF033700.1      blaCMA
           Family Added:  -               blaCRD3
           Family Added:  NF033698.1      blaCSA
           Family Added:  -               blaCrA
           Family Added:  -               blaDHT2
           Family Added:  -               blaEAM
           Family Added:  -               blaECM
           Family Added:  -               blaEFM
           Family Added:  -               blaELM
           Family Added:  -               blaEVM
           Family Added:  -               blaGRD23
           Family Added:  -               blaGRD33
           Family Added:  NF033702.0      blaOXA-12_like
           Family Added:  -               blaPNGM
           Family Added:  -               blaSPN79
           Family Added:  -               catV
           Family Added:  -               crpP
           Family Added:  -               dfrA34
           Family Added:  -               qacE
         Family Renamed:  NF033666.1      blaOXA-664_like became blaOXA-727_like

---------------------------------------------------------------------
Changes included in 2018-09-14.1
----------------------------------------------------------------------
- Protein changes:
      Prev. Release:  4569
       This Release:  4579
            Removed:     0
              Added:    10
      Protein Added:  WP_116786828.1  mcr-4.6
      Protein Added:  WP_116786829.1  blaCTX-M-222
      Protein Added:  WP_116786830.1  mcr-1.15
      Protein Added:  WP_116786831.1  blaTEM-236
      Protein Added:  WP_116786832.1  blaKPC-37
      Protein Added:  WP_116786834.1  blaPDC-304
      Protein Added:  WP_116786836.1  blaOXA-667
      Protein Added:  WP_116786837.1  blaPDC-305
      Protein Added:  WP_116786838.1  blaPDC-306
      Protein Added:  WP_116786839.1  blaIMP-79
- AMR HMM library Changes:
      Prev. Release:   563
       This Release:   563
            Removed:     0
              Added:     0
- Protein family changes:
      Prev. Release:  1133
       This Release:  1133
            Removed:     0
              Added:     0

---------------------------------------------------------------------
Changes included in 2018-08-24.1
---------------------------------------------------------------------
- Protein changes:
      Prev. Release:  4563
       This Release:  4569
            Removed:     1
              Added:     7
        Protein Removed:  WP_063843217.1  catA1
          Protein Added:  WP_003436401.1  vanR-Cd
          Protein Added:  WP_009889012.1  vanZ1
          Protein Added:  WP_011861275.1  vanS-Cd
          Protein Added:  WP_011861276.1  vanG-Cd
          Protein Added:  WP_020924773.1  blaAXC-1
          Protein Added:  WP_072310976.1  mcr-8.2
          Protein Added:  WP_072678505.1  blaOXA-669
- AMR HMM library Changes:
      Prev. Release:   563
       This Release:   563
            Removed:     0
              Added:     0
- Protein family changes:
      Prev. Release:  1128
       This Release:  1133
            Removed:     0
              Added:     5
           Family Added:  -               blaAXC
           Family Added:  -               vanG-Cd
           Family Added:  -               vanR-Cd
           Family Added:  -               vanS-Cd
           Family Added:  -               vanZ1

---------------------------------------------------------------------
Changes included in 2018-08-01.1
---------------------------------------------------------------------
- Protein changes:
      Prev. Release:  4528
       This Release:  4563
            Removed:     0
              Added:    35
          Protein Added:  WP_000622776.1  qacA
          Protein Added:  WP_001159761.1  blaADC-176
          Protein Added:  WP_001211208.1  blaADC-175
          Protein Added:  WP_010730188.1  qacZ
          Protein Added:  WP_013095270.1  blaCMH-4
          Protein Added:  WP_032410229.1  blaOXA-663
          Protein Added:  WP_033487869.1  blaACT-56
          Protein Added:  WP_046887417.1  blaCMH-5
          Protein Added:  WP_047052637.1  blaACT-55
          Protein Added:  WP_050861789.1  blaACT-64
          Protein Added:  WP_070210118.1  blaOXA-658
          Protein Added:  WP_094935119.1  blaACT-57
          Protein Added:  WP_111772163.1  blaVIM-58
          Protein Added:  WP_111976052.1  blaACT-60
          Protein Added:  WP_112017656.1  blaACT-61
          Protein Added:  WP_112792421.1  blaACT-59
          Protein Added:  WP_114699266.1  blaOXA-666
          Protein Added:  WP_114699267.1  blaKPC-36
          Protein Added:  WP_114699268.1  blaADC-174
          Protein Added:  WP_114699269.1  blaADC-177
          Protein Added:  WP_114699270.1  blaADC-178
          Protein Added:  WP_114699271.1  blaADC-179
          Protein Added:  WP_114699272.1  blaADC-180
          Protein Added:  WP_114699273.1  blaOXA-661
          Protein Added:  WP_114699274.1  blaOXA-662
          Protein Added:  WP_114699275.1  mcr-8.1
          Protein Added:  WP_114699276.1  blaOXA-659
          Protein Added:  WP_114699277.1  blaVIM-60
          Protein Added:  WP_114699278.1  mcr-5.3
          Protein Added:  WP_114699279.1  blaOXA-660
          Protein Added:  WP_114699280.1  blaIMP-76
          Protein Added:  WP_114699281.1  blaIMP-77
          Protein Added:  WP_114699282.1  blaIMP-78
          Protein Added:  WP_114699283.1  blaVIM-59
          Protein Added:  WP_114699284.1  blaCTX-M-221
- AMR HMM library Changes:
      Prev. Release:   557
       This Release:   563
            Removed:     0
              Added:     6
              HMM Added:  NF033648.1      blaOXA-274_like
              HMM Added:  NF033666.1      blaOXA-664_like
              HMM Added:  NF033667.0      blaOXA-55_like
              HMM Added:  NF033669.1      polymyxin_MCR8
              HMM Added:  NF033670.1      polymyxin_MCR6
              HMM Added:  NF033671.1      polymyxin_MCR7
- Protein family changes:
      Prev. Release:  1123
       This Release:  1128
            Removed:     0
              Added:     5
           Family Added:  -               blaOXA-266_fam
           Family Added:  NF033648.1      blaOXA-274_like
           Family Added:  NF033667.1      blaOXA-55_like
           Family Added:  NF033666.1      blaOXA-664_like
           Family Added:  NF033669.1      mcr-8
              HMM Added:  mcr-6         updated to NF033670.1 mcr-6
              HMM Added:  mcr-7         updated to NF033671.1 mcr-7

Updates in 2018-07-07.1
- Fix in amr_report.cpp to remove extra field from AMRFinder output

Updates in 2018-06-27.1
- Summary:
    - Protein sequences
        - Removed 1 protein sequence
        - Added 290 protein sequences
        - Changed the names of 2 proteins
    - Gene families
        - cfr was reorganized
    - HMM library
        - 58 HMMs not in the AMR family hierarchy were removed. They were not
          used for AMR gene identification so this should have no effect on
          AMRFinder output.
        - The polymyxin_MCR3 HMM was updated
- Details:
        Protein Removed:  WP_063945333.1  aac(6')-IIa
          Protein Added:  WP_000131886.1  aac(3)-VIa
          Protein Added:  WP_000778180.1  varG
          Protein Added:  WP_001100752.1  blaPER-10
          Protein Added:  WP_002812372.1  blaOXA-578
          Protein Added:  WP_002824679.1  blaOXA-595
          Protein Added:  WP_002837769.1  blaOXA-579
          Protein Added:  WP_002857546.1  blaOXA-592
          Protein Added:  WP_002889704.1  blaOXA-591
          Protein Added:  WP_002936877.1  blaOXA-623
          Protein Added:  WP_011339581.1  blaRHO
          Protein Added:  WP_011497575.1  blaSHN-1
          Protein Added:  WP_011550565.1  blaMYX-1
          Protein Added:  WP_011638903.1  mcr-4.3
          Protein Added:  WP_012263521.1  mupA
          Protein Added:  WP_012541790.1  blaLEN-28
          Protein Added:  WP_012698469.1  blaLHK-7
          Protein Added:  WP_013255389.1  blaSPS-1
          Protein Added:  WP_013992183.1  blaZOG-1
          Protein Added:  WP_014206564.1  blaOXA-642
          Protein Added:  WP_015058260.1  qnrS11
          Protein Added:  WP_015266427.1  blaECV-1
          Protein Added:  WP_015431537.1  blaROB-2
          Protein Added:  WP_015818996.1  blaTTU-1
          Protein Added:  WP_016252988.1  blaPDC-286
          Protein Added:  WP_021018581.1  catB8
          Protein Added:  WP_025006557.1  blaOXA-580
          Protein Added:  WP_026025287.1  blaALI-1
          Protein Added:  WP_031192893.1  aadA31
          Protein Added:  WP_034035338.1  blaPDC-240
          Protein Added:  WP_035203840.1  catA10
          Protein Added:  WP_038333643.1  blaEBR-2
          Protein Added:  WP_038640920.1  qnrB12
          Protein Added:  WP_041079981.1  erm(44)v
          Protein Added:  WP_041258349.1  blaFIA-1
          Protein Added:  WP_041385949.1  blaSGM-2
          Protein Added:  WP_041449074.1  blaANA-1
          Protein Added:  WP_043774378.1  catA13
          Protein Added:  WP_043942497.1  blaPST-1
          Protein Added:  WP_044600959.1  blaOXA-594
          Protein Added:  WP_044779552.1  blaOXA-638
          Protein Added:  WP_048236419.1  qnrB85
          Protein Added:  WP_052259183.1  erm(42)
          Protein Added:  WP_052781249.1  blaOXA-583
          Protein Added:  WP_052788483.1  blaOXA-611
          Protein Added:  WP_052788887.1  blaOXA-581
          Protein Added:  WP_052794776.1  blaOXA-625
          Protein Added:  WP_052798312.1  blaOXA-609
          Protein Added:  WP_052800105.1  blaOXA-597
          Protein Added:  WP_052803794.1  blaOXA-601
          Protein Added:  WP_052858477.1  blaOXA-637
          Protein Added:  WP_053872444.1  blaOXA-639
          Protein Added:  WP_053921012.1  blaOXA-603
          Protein Added:  WP_057036510.1  blaOXA-629
          Protein Added:  WP_058157026.1  blaPDC-271
          Protein Added:  WP_058174497.1  blaPDC-250
          Protein Added:  WP_058870660.1  blaOXA-651
          Protein Added:  WP_058951457.1  blaOXA-652
          Protein Added:  WP_061193431.1  blaPDC-298
          Protein Added:  WP_064186845.1  qnrS13
          Protein Added:  WP_065597326.1  blaALI-2
          Protein Added:  WP_065801616.1  mcr-3.20
          Protein Added:  WP_065908739.1  qnrB91
          Protein Added:  WP_070233680.1  blaOXA-614
          Protein Added:  WP_070698497.1  blaPDC-278
          Protein Added:  WP_071701819.1  qnrS12
          Protein Added:  WP_071846333.1  aac(6')_Serra
          Protein Added:  WP_073669325.1  blaPDC-285
          Protein Added:  WP_075606311.1  blaROB-3
          Protein Added:  WP_078207746.1  qnrE2
          Protein Added:  WP_078318620.1  blaROB-4
          Protein Added:  WP_080699425.1  blaTEM-229
          Protein Added:  WP_081048762.1  blaMYO-1
          Protein Added:  WP_081666691.1  blaLHK-1
          Protein Added:  WP_085843691.1  qnrB95
          Protein Added:  WP_087696200.1  blaOXA-576
          Protein Added:  WP_087879616.1  mcr-3.19
          Protein Added:  WP_088303859.1  blaOXA-624
          Protein Added:  WP_094308975.1  mcr-3.22
          Protein Added:  WP_094312656.1  mcr-3.21
          Protein Added:  WP_094313523.1  mcr-3.23
          Protein Added:  WP_094321595.1  mcr-3.24
          Protein Added:  WP_094963248.1  aadA31
          Protein Added:  WP_096170112.1  qnrS14
          Protein Added:  WP_096865225.1  blaPER-12
          Protein Added:  WP_100831609.1  blaPDC-245
          Protein Added:  WP_103034696.1  blaROB-5
          Protein Added:  WP_103252528.1  mcr-3.25
          Protein Added:  WP_104009831.1  blaPER-11
          Protein Added:  WP_104009832.1  blaPDC-234
          Protein Added:  WP_104009833.1  blaPDC-235
          Protein Added:  WP_104009834.1  blaPDC-236
          Protein Added:  WP_104009835.1  blaPDC-237
          Protein Added:  WP_104009836.1  blaPDC-238
          Protein Added:  WP_104009837.1  blaPDC-239
          Protein Added:  WP_104009838.1  blaPDC-241
          Protein Added:  WP_104009839.1  blaPDC-242
          Protein Added:  WP_104009840.1  blaPDC-243
          Protein Added:  WP_104009841.1  blaPDC-244
          Protein Added:  WP_104009842.1  blaPDC-246
          Protein Added:  WP_104009843.1  blaPDC-247
          Protein Added:  WP_104009844.1  blaPDC-248
          Protein Added:  WP_104009846.1  blaVIM-56
          Protein Added:  WP_104009847.1  blaCTX-M-178
          Protein Added:  WP_104009848.1  blaCTX-M-187
          Protein Added:  WP_104009849.1  blaCMY-156
          Protein Added:  WP_104009850.1  mcr-1.12
          Protein Added:  WP_104009851.1  mcr-7.1
          Protein Added:  WP_104009852.1  blaIMP-71
          Protein Added:  WP_104009853.1  blaOXA-575
          Protein Added:  WP_104009854.1  blaTEM-230
          Protein Added:  WP_104009855.1  blaTEM-231
          Protein Added:  WP_104009856.1  blaPDC-227
          Protein Added:  WP_104009857.1  blaPDC-228
          Protein Added:  WP_104009858.1  blaPDC-229
          Protein Added:  WP_104009859.1  blaPDC-230
          Protein Added:  WP_104009860.1  blaPDC-231
          Protein Added:  WP_104009861.1  blaPDC-232
          Protein Added:  WP_104009862.1  blaPDC-233
          Protein Added:  WP_104531863.1  blaBUT-1
          Protein Added:  WP_104531864.1  blaBUT-2
          Protein Added:  WP_104531865.1  blaLHK-2
          Protein Added:  WP_104531866.1  blaLHK-3
          Protein Added:  WP_104531867.1  blaLHK-4
          Protein Added:  WP_104531868.1  blaLHK-5
          Protein Added:  WP_104531869.1  blaLHK-6
          Protein Added:  WP_106672612.1  blaCMY-150
          Protein Added:  WP_106924209.1  blaCTX-M-213
          Protein Added:  WP_109544237.1  tet(S)
          Protein Added:  WP_109545031.1  dfrA14
          Protein Added:  WP_109545032.1  qnrB11
          Protein Added:  WP_109545033.1  vanY-D
          Protein Added:  WP_109545034.1  qnrB22
          Protein Added:  WP_109545035.1  qacF
          Protein Added:  WP_109545038.1  tet(33)
          Protein Added:  WP_109545039.1  blaSTA-1
          Protein Added:  WP_109545040.1  chrB
          Protein Added:  WP_109545041.1  aph(3'')-Ib
          Protein Added:  WP_109545042.1  blaORR-1
          Protein Added:  WP_109545044.1  blaKPC-34
          Protein Added:  WP_109545045.1  qnrD3
          Protein Added:  WP_109545046.1  qnrB81
          Protein Added:  WP_109545047.1  qnrB82
          Protein Added:  WP_109545048.1  blaOXA-542
          Protein Added:  WP_109545049.1  blaNDM-20
          Protein Added:  WP_109545050.1  blaCRH-2
          Protein Added:  WP_109545051.1  blaCRH-3
          Protein Added:  WP_109545053.1  blaIMP-73
          Protein Added:  WP_109545054.1  mcr-4.5
          Protein Added:  WP_109545055.1  mcr-4.4
          Protein Added:  WP_109545056.1  mcr-1.13
          Protein Added:  WP_109545057.1  mcr-5.2
          Protein Added:  WP_109545058.1  mcr-4.2
          Protein Added:  WP_109545059.1  blaTEM-232
          Protein Added:  WP_109545060.1  blaCTX-M-208
          Protein Added:  WP_109545061.1  blaCTX-M-209
          Protein Added:  WP_109545062.1  blaCTX-M-210
          Protein Added:  WP_109545063.1  blaCTX-M-211
          Protein Added:  WP_109545064.1  blaCTX-M-212
          Protein Added:  WP_109545065.1  blaCMY-161
          Protein Added:  WP_109545066.1  blaFOX-16
          Protein Added:  WP_109545067.1  blaDHA-27
          Protein Added:  WP_109545068.1  blaDHA-26
          Protein Added:  WP_109545069.1  blaCTX-M-214
          Protein Added:  WP_109545070.1  mcr-3.12
          Protein Added:  WP_109545071.1  blaOXA-649
          Protein Added:  WP_109545072.1  blaOXA-641
          Protein Added:  WP_109545073.1  blaFRI-5
          Protein Added:  WP_109545074.1  blaGPC-1
          Protein Added:  WP_109545075.1  blaOXA-619
          Protein Added:  WP_109545076.1  blaOXA-620
          Protein Added:  WP_109545077.1  blaOXA-636
          Protein Added:  WP_109545078.1  blaOXA-635
          Protein Added:  WP_109545079.1  blaOXA-631
          Protein Added:  WP_109545080.1  blaOXA-626
          Protein Added:  WP_109545081.1  blaOXA-627
          Protein Added:  WP_109545082.1  blaOXA-633
          Protein Added:  WP_109545083.1  blaOXA-628
          Protein Added:  WP_109545084.1  blaOXA-634
          Protein Added:  WP_109545085.1  blaOXA-630
          Protein Added:  WP_109545086.1  blaOXA-632
          Protein Added:  WP_109545087.1  blaOXA-608
          Protein Added:  WP_109545088.1  blaOXA-584
          Protein Added:  WP_109545089.1  blaOXA-585
          Protein Added:  WP_109545090.1  blaOXA-586
          Protein Added:  WP_109545091.1  blaOXA-577
          Protein Added:  WP_109545092.1  blaOXA-587
          Protein Added:  WP_109545093.1  blaOXA-596
          Protein Added:  WP_109545094.1  blaOXA-600
          Protein Added:  WP_109545095.1  blaOXA-588
          Protein Added:  WP_109545096.1  blaOXA-589
          Protein Added:  WP_109545097.1  blaOXA-593
          Protein Added:  WP_109545098.1  blaOXA-599
          Protein Added:  WP_109545099.1  blaOXA-610
          Protein Added:  WP_109545100.1  blaOXA-612
          Protein Added:  WP_109545101.1  blaOXA-598
          Protein Added:  WP_109545102.1  blaOXA-607
          Protein Added:  WP_109545103.1  blaOXA-590
          Protein Added:  WP_109545104.1  blaOXA-604
          Protein Added:  WP_109545105.1  blaOXA-602
          Protein Added:  WP_109545106.1  blaOXA-606
          Protein Added:  WP_109545107.1  blaOXA-582
          Protein Added:  WP_109545108.1  blaOXA-605
          Protein Added:  WP_109545109.1  blaOXA-640
          Protein Added:  WP_109545110.1  blaOXA-616
          Protein Added:  WP_109545111.1  blaOXA-613
          Protein Added:  WP_109545112.1  blaOXA-622
          Protein Added:  WP_109545113.1  blaOXA-618
          Protein Added:  WP_109545114.1  blaOXA-617
          Protein Added:  WP_109545115.1  blaOXA-615
          Protein Added:  WP_109545116.1  blaOXA-621
          Protein Added:  WP_109791184.1  blaTEM-233
          Protein Added:  WP_109791185.1  blaPDC-251
          Protein Added:  WP_109791186.1  blaPDC-252
          Protein Added:  WP_109791187.1  blaPDC-253
          Protein Added:  WP_109791188.1  blaPDC-254
          Protein Added:  WP_109791189.1  blaPDC-255
          Protein Added:  WP_109791190.1  blaPDC-256
          Protein Added:  WP_109791191.1  blaPDC-257
          Protein Added:  WP_109791192.1  blaPDC-258
          Protein Added:  WP_109791193.1  blaPDC-259
          Protein Added:  WP_109791194.1  blaPDC-260
          Protein Added:  WP_109791195.1  blaPDC-261
          Protein Added:  WP_109791196.1  blaPDC-262
          Protein Added:  WP_109791197.1  blaPDC-263
          Protein Added:  WP_109791198.1  blaPDC-264
          Protein Added:  WP_109791199.1  blaPDC-265
          Protein Added:  WP_109791200.1  blaPDC-266
          Protein Added:  WP_109791201.1  blaPDC-267
          Protein Added:  WP_109791202.1  blaPDC-268
          Protein Added:  WP_109791203.1  blaPDC-270
          Protein Added:  WP_109791204.1  blaPDC-272
          Protein Added:  WP_109791205.1  blaPDC-273
          Protein Added:  WP_109791206.1  blaPDC-274
          Protein Added:  WP_109791207.1  blaIMP-74
          Protein Added:  WP_109791208.1  blaIMP-75
          Protein Added:  WP_109791209.1  blaCTX-M-216
          Protein Added:  WP_109791210.1  blaTEM-234
          Protein Added:  WP_109791211.1  blaCTX-M-217
          Protein Added:  WP_109791212.1  blaSHV-204
          Protein Added:  WP_109791213.1  blaNDM-22
          Protein Added:  WP_109791214.1  blaCTX-M-218
          Protein Added:  WP_109791215.1  blaCMY-160
          Protein Added:  WP_109791216.1  blaOXA-654
          Protein Added:  WP_109997726.1  qnrA9
          Protein Added:  WP_110092882.1  blaCTX-M-219
          Protein Added:  WP_111273842.1  mcr-3.13
          Protein Added:  WP_111273843.1  mcr-3.14
          Protein Added:  WP_111273844.1  mcr-3.15
          Protein Added:  WP_111273845.1  mcr-3.16
          Protein Added:  WP_111273846.1  mcr-3.17
          Protein Added:  WP_111273847.1  mcr-3.18
          Protein Added:  WP_111273848.1  blaGES-35
          Protein Added:  WP_111273849.1  blaGES-36
          Protein Added:  WP_111273850.1  blaGES-37
          Protein Added:  WP_111273851.1  blaCMY-162
          Protein Added:  WP_111273852.1  blaKPC-35
          Protein Added:  WP_111672883.1  blaPDC-275
          Protein Added:  WP_111672884.1  blaPDC-294
          Protein Added:  WP_111672885.1  blaPDC-295
          Protein Added:  WP_111672886.1  blaPDC-296
          Protein Added:  WP_111672887.1  blaPDC-297
          Protein Added:  WP_111672888.1  blaPDC-299
          Protein Added:  WP_111672889.1  blaPDC-300
          Protein Added:  WP_111672890.1  blaPDC-276
          Protein Added:  WP_111672891.1  blaPDC-277
          Protein Added:  WP_111672892.1  blaPDC-279
          Protein Added:  WP_111672893.1  blaPDC-280
          Protein Added:  WP_111672894.1  blaPDC-281
          Protein Added:  WP_111672895.1  blaPDC-282
          Protein Added:  WP_111672896.1  blaPDC-283
          Protein Added:  WP_111672897.1  blaPDC-284
          Protein Added:  WP_111672898.1  blaPDC-287
          Protein Added:  WP_111672899.1  blaPDC-288
          Protein Added:  WP_111672900.1  blaPDC-289
          Protein Added:  WP_111672901.1  blaPDC-290
          Protein Added:  WP_111672902.1  blaCTX-M-220
          Protein Added:  WP_111672903.1  blaPDC-291
          Protein Added:  WP_111672904.1  blaPDC-292
          Protein Added:  WP_111672905.1  blaPDC-293
          Protein Added:  WP_111672906.1  blaCMY-163
          Protein Added:  WP_111672907.1  blaOXA-657
          Protein Added:  WP_111672908.1  blaPDC-301
          Protein Added:  WP_111672909.1  blaPDC-302
          Protein Added:  WP_111672910.1  blaPDC-303
          Protein Added:  WP_111672911.1  blaKPC-23
          Protein Added:  WP_111672912.1  blaNDM-23
          Protein Added:  WP_111672913.1  blaNDM-24
          Protein Added:  WP_111672914.1  blaVIM-57
          Protein Added:  WP_111690897.1  cfr(B)
          Protein Added:  WP_111690898.1  cfr(C)
       Protein Modified:  WP_011987126.1 cfrC updated to WP_011987126.1 cfr-Cb
       Protein Modified:  WP_063854808.1 qnrS updated to WP_063854808.1 qnrS10
            HMM Removed:  NF000031.1      MFS_efflux_LmrA
            HMM Removed:  NF000040.1      172051428_tet
            HMM Removed:  NF000058.1      Erm41
            HMM Removed:  NF000060.1      MFS_efflux_LmrB
            HMM Removed:  NF000106.1      40850658_otr
            HMM Removed:  NF000131.1      MATE_multi_MepA
            HMM Removed:  NF000140.3      AAC_6p_Salmo
            HMM Removed:  NF000217.1      MATE_multi_FepA
            HMM Removed:  NF000247.1      MexA
            HMM Removed:  NF000249.1      MexE
            HMM Removed:  NF000250.1      MexH
            HMM Removed:  NF000251.1      MexW-MexI
            HMM Removed:  NF000252.1      MexX
            HMM Removed:  NF000263.1      MATE_multi_NorM
            HMM Removed:  NF000282.2      RND_permease_1
            HMM Removed:  NF000313.1      adeA-adeI
            HMM Removed:  NF000314.1      adeB
            HMM Removed:  NF000315.1      adeC-adeK-oprM
            HMM Removed:  NF000334.3      drrA
            HMM Removed:  NF000336.1      emrE
            HMM Removed:  NF000342.3      glpA_Cterm
            HMM Removed:  NF000344.1      macA
            HMM Removed:  NF000345.1      macB
            HMM Removed:  NF000349.1      mfpA_AE000516.2
            HMM Removed:  NF000352.1      norA
            HMM Removed:  NF000357.1      romA
            HMM Removed:  NF000391.1      EmrB
            HMM Removed:  NF010314.2      PRK13751.2
            HMM Removed:  NF012135.0      ANT_3pp_9_crypt
            HMM Removed:  NF012144.2      ramA_TF
            HMM Removed:  NF012163.2      BaeS_SmeS
            HMM Removed:  NF012168.1      BlaI_of_BCL
            HMM Removed:  NF012198.0      MarA_TF
            HMM Removed:  NF012208.0      SDR_dihy_bifunc
            HMM Removed:  NF012226.0      AdeS_HK
            HMM Removed:  NF012227.0      AdeR_RR
            HMM Removed:  NF012228.1      RobA_TF
            HMM Removed:  NF028537.1      P_eth_NH2_trans
            HMM Removed:  NF030466.0      TIGR02052
            HMM Removed:  NF030467.0      TIGR02053
            HMM Removed:  NF033086.2      penta_rpt_Qnr
            HMM Removed:  NF033124.1      estX
            HMM Removed:  NF033134.0      cmlA_floR
            HMM Removed:  NF033138.1      RND-peri-MexC
            HMM Removed:  NF033142.1      efflux_OM_AdeC
            HMM Removed:  NF033143.1      efflux_OM_AdeK
            HMM Removed:  NF033184.1      B3_Acin_new1
            HMM Removed:  NF033480.1      bifunc_MprF
            HMM Removed:  NF033553.1      MerP_Gpos
            HMM Removed:  NF033555.1      lyase_MerB
            HMM Removed:  NF033556.1      MerTP_fusion
            HMM Removed:  NF033560.1      merT_RC607
            HMM Removed:  NF033565.0      trans_MerF
            HMM Removed:  NF033606.1      heat_AAA_ClpK
            HMM Removed:  NF033607.0      disagg_AAA_ClpG
            HMM Removed:  NF033617.1      RND_permease_2
            HMM Removed:  NF033627.1      intimin_all
            HMM Removed:  NF033636.1      acid_shock_Asr
           HMM Modified:  NF033408.2 polymyxin_MCR3 updated to NF033408.5 polymyxin_MCR3
         Family Removed:  -               cfrC
           Family Added:  -               cfr(B)
           Family Added:  -               cfr(C)
           Family Added:  -               cfr-Cb
         Family Changed:  NF033408.2 mcr-3 updated to NF033408.5 mcr-3

---------------------------------------------------------------------
Changes included in 2018-05-15.1
---------------------------------------------------------------------
- Data Changes:
        Protein Removed:  WP_010886396.1  lmr(B)
              HMM Added:  NF033614.1      APH_6_Ic_gen
              HMM Added:  NF033617.1      RND_permease_2
              HMM Added:  NF033626.1      blaBKC_GPC
              HMM Added:  NF033627.1      intimin_all
              HMM Added:  NF033636.1      acid_shock_Asr
           HMM Modified:  NF000011.1      APH_6_Ic updated to NF000011.2 APH_6_Ic
           HMM Modified:  NF000221.3      FosA updated to NF000221.4 FosA
           HMM Modified:  NF000282.1      RND_permease_1 updated to NF000282.2 RND_permease_1
           HMM Modified:  NF000428.2      blaFRI updated to NF000428.4 blaFRI
           HMM Modified:  NF033582.0      blaALI updated to NF033582.2 blaALI
         Family Removed:  NF000060.1      lmr(B)
           Family Added:  NF033626.1      blaBKC_GPC
           Family Added:  -               blaGPC
- Algorithm Changes:
    - Partial proteins identified as "Method" PARTIAL if length of blast
      alignment > 50% and < 90% of database protein.

---------------------------------------------------------------------
Changes included in 2018-05-08.1  RELEASE CANDIDATE
---------------------------------------------------------------------
- Addition of handling for genbank plasmid gff

---------------------------------------------------------------------
Changes included in 2018-04-16.1
---------------------------------------------------------------------
- Addition of file format checking for FASTA and GFF files before AMRFinder blast and HMM searches are run
- Altered format of fam.tab file to include NF accessions for families
- Removal of non-reportable families from fam.tab
